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Dissertations / Theses on the topic 'Mechanism of action of melatonin'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Avila, Goñi Leonor. "Human melatonin receptors molecular mechanisms of action and their implication in cell proliferation /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968548989.

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2

Giddins, R. E. "Behavioural and biochemical correlates of melatonin action in the rodent brain." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371472.

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3

Lemus-Wilson, Athena Marie. "Melatonin and breast cancer: Investigation of a potential involvement of prolactin in the mechanism by which melatonin inhibits cell growth." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186578.

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The pineal hormone melatonin (MLT) inhibits the promotion of human breast cancer cell growth in vitro by prolactin (PRL). When MCF-7 estrogen receptor (ER) positive human breast cancer cells were grown in a monolayer culture system containing 5% charcoal-stripped fetal bovine serum (CSS) in the presence of PRL and/or MLT for up to 6-days, MLT at each of the time-points tested significantly reduced the mitogenic response to PRL. In fact, in some instances the addition of MLT further reduced growth below the levels of untreated controls. Doses of MLT within the normal nighttime physiological ran

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4

Thapan, Kavita. "The spectral sensitivity of light-induced melatonin suppression in humans." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365184.

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5

Tatarski, Miloš. "Molecular mechanism of dBigH1 action." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663021.

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INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo shows typically zero to very little activity of transcription, and the first cleavages of the embryo depend exclusively on maternally deposited factors that are important for transcription and chromatin assembly. The first species shown to contain an embryo specific histone H1 was the sea urchin. Other species like the mouse, Xenopus or the zebrafish followed. Even in humans t

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6

Attarzadeh, Yazdi Ghassem. "Molecular mechanism of glucocorticoid action." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/26161.

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The aim of this thesis project was to investigate the mechanisms by which glucocorticoid hormones regulate the activity of BK channels in human embryonic kidney 293 (HEK293) cells as the model system for glucocorticoids-action. It was shown that glucocorticoids act <i>via </i>endogenously expressed type II receptors in a concentration- and time-dependent manner in these cells. Dexamethasone (100 nM) had no significant effect on <i>Dexras1 </i>mRNA but significantly increased serum- and glucocorticoid-induced protein kinase 1 (SGK-1) mRNA. Biochemical analysis showed that SGK-1 protein is incre

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7

Conti, Lucio. "The molecular mechanism of TFL1 action." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423575.

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During Arabidopsis development the shoot apical meristem (SAM) generates lateral primordia which display stage-specific traits. In long days, wild-type Arabidopsis generates leaves in an initial vegetative phase (V). Upon integration of environmental and endogenous signals, the SAM enters the reproductive phase. First it makes an 11 phase, which consists of 2-3 leaves (cauline) subtending secondary shoots (coflorescences). Next it enters the 12 phase and produces flowers on its flanks. The TFL 1 gene is a key component of the phase change machinery as mutations in TFL 1 affect the timing of ph

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8

Beastall, J. C. "The mechanism of action of azone." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380112.

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9

Williams, Daffydd Griffin. "Mechanism of action of penetration enhancers." Thesis, Cardiff University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320625.

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10

Taylor, Catherine. "A mechanism of action of strigolactone." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709140.

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11

Taylor, M. R. G. "Mechanism of action of Rad51 paralogs." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1458671/.

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Homologous recombination (HR) is an essential DNA break repair mechanism that remains incompletely understood. HR is a complex multistep process initiated by the loading of RAD-51 recombinase as filaments onto single stranded DNA (ssDNA). This structure directly invades an intact homologous duplex, which serves as a template for repair DNA synthesis. Numerous positive regulators of HR have been described, including the Rad51 paralogs, but the mechanism of action of Rad51 paralogs in promoting HR is unknown. In this study, I have characterized the mechanism of action of a novel Rad51 paralog co

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12

Phisit, Prapunwattana Yongyuth Yuthavong. "Mechanism of antimalarial action of tetracycline /." abstract, 1986. http://mulinet3.li.mahidol.ac.th/thesis/2529/29E-Phisit-P.pdf.

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13

Díaz, i. Cirac Anna. "Mechanism of action of cyclic antimicrobial peptides." Doctoral thesis, Universitat de Girona, 2011. http://hdl.handle.net/10803/38252.

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This PhD thesis is the result of the combination of experimental and computational techniques with the aim of understanding the mechanism of action of de novo cyclic decapeptides with high antimicrobial activity. By experimental techniques the influence of the replacement of the phenylalanine for tryptophan residue in their antimicrobial activity was tested and the stability in human serum was also analyzed, in order to evaluate their potential therapeutic application as antitumor agents. On the other hand, the interaction amongst the peptide BPC194 c(KKLKKFKKLQ), the best candidate from the

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14

Reißmann, Stefanie. "Mechanism of Action of Group II Chaperonins:." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-73195.

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15

Hirschkorn, Martin C. "Dynamic Model of a Piano Action Mechanism." Thesis, University of Waterloo, 2004. http://hdl.handle.net/10012/877.

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While some attempts have been made to model the behaviour of the grand piano action (the mechanism that translates a key press into a hammer striking a string), most researchers have reduced the system to a simple model with little relation to the components of a real action. While such models are useful for certain applications, they are not appropriate as design tools for piano makers, since the model parameters have little physical meaning and must be calibrated from the behaviour of a real action. A new model for a piano action is proposed in this thesis. The model treats each

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16

Plested, Charles Paul. "Mechanism of action of seronegative myasthenia gravis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301392.

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17

Keane, Richard. "HPMA copolymer-aminoellipticine conjugates : mechanism of action." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269617.

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18

Beecroft, Marikka Shannon. "Antimicrobial chelators and their mechanism of action." Thesis, Durham University, 2019. http://etheses.dur.ac.uk/12933/.

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Limiting the availability of metals in an environment is known to restrict bacterial growth and proliferation. For example, humans sequester metals to help prevent infection by pathogens, a system termed nutritional immunity. Chelators are small molecules that bind tightly to metals and thus have antibacterial properties that mimic these innate immune processes. This activity of chelators has not been studied extensively, although experiments with EDTA suggest that it disrupts bacterial membrane permeability by stripping lipopolysaccharide from the bacterial outer surface, possibly due to the

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19

Matkar, Smita S. "Mechanism of action of potential anticancer drugs." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2368.

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Traditionally, inoperable or metastatic cancers have been treated by causing massive DNA damage in order to induce self-destruction (apoptosis) of the rapidly multiplying cancer cells. Initially, this strategy works for many cancers, in particular those which express normal p53 tumor suppressor protein. However, most cancers eventually aquire mutations in either p53 or other signaling molecules and fail to initiate apoptosis in response to severe DNA damage. During this study three types of compounds were investigated for their DNA damaging and anticancer effects: a pair of novel metal contain

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20

Chant, Eleanor Laura. "The mechanism of action of ColE1 Rcd." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613713.

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21

Jackson, Natalie Diane. "The mechanism of action of peroxygen biocides." Thesis, University of York, 1999. http://etheses.whiterose.ac.uk/9825/.

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22

Bagnobianchi, A. "The molecular mechanism of action of Bendamustine." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1461456/.

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Bendamustine has demonstrated clinical efficacy in the treatment of haematological malignancies and distinguish itself from other alkylating agents. The mechanistic and clinical differences associated with Bendamustine may be related to its structural features including a benzimidazole ring, although the mechanism of action is poorly understood. Understanding the molecular mechanism of Bendamustine could explain the therapeutic efficacy and identify potential biomarkers for response. The Bendamustine-DNA interaction in naked DNA, cytotoxicity, and ICL formation and repair (unhooking) in naked

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23

Novikova, Natalia. "Mechanism of action of emergency contraceptive pill." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2151.

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The number of unwanted pregnancies has not decreased in recent years and this should be addressed. Emergency contraception may be effective when used correctly having the advantage that it can be used after an episode of unprotected sexual intercourse (when regular contraception has failed or was not used). In this research project I set out to explore some of the major reasons why there are still many unwanted pregnancies in Australia. I decided to focus on the use and non-use of emergency contraception, e.g. emergency contraception pill (ECP) “method failures” are not well understood becau

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24

Novikova, Natalia. "Mechanism of action of emergency contraceptive pill." University of Sydney, 2007. http://hdl.handle.net/2123/2151.

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Master of Medicine<br>The number of unwanted pregnancies has not decreased in recent years and this should be addressed. Emergency contraception may be effective when used correctly having the advantage that it can be used after an episode of unprotected sexual intercourse (when regular contraception has failed or was not used). In this research project I set out to explore some of the major reasons why there are still many unwanted pregnancies in Australia. I decided to focus on the use and non-use of emergency contraception, e.g. emergency contraception pill (ECP) “method failures” are not w

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25

Muraro, Lucia. "Studies of Botulinum Neurotoxins Mechanism of Action." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425607.

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Botulinum neurotoxins (7 serotypes of BoNTs, named from A to G) and tetanus neurotoxin (TeNT) are the most powerful clostridial toxins (CNTs). They are responsible for botulism and tetanus respectively. TeNT and BoNTs bind to peripheral nerve terminals and inhibit neurotransmitter release from presynaptic neuronal cells by proteolytic cleavage of proteins involved in the fusion of synaptic vesicles with the cell membrane. BoNTs act at the level of Peripheral Nervous System (PNS) causing flaccid paralysis whereas TeNT acts at the level of Central Nervous System (CNS) causing spastic paralysis.

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26

Fetsch, Christopher Robert. "Neuronal Responses to Melatonin in Peromyscus leucopus: A Candidate Mechanism for Circadian and Seasonal Temperature Regulation." W&M ScholarWorks, 2004. https://scholarworks.wm.edu/etd/1539626451.

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27

Davoodi, Jamshid. "Bacillus circulans xylanase: Stability and mechanism of action." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/10216.

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The stability and mechanism of the action of the enzyme Bacillus circulans xylanase (1,4-$\beta$-D-xylanohydrolase, EC 3.2.1.8) were investigated by various biophysical techniques. On the basis of the sequence homology between B. circulans xylanase and xylanase A from Schizophyllum commune, a disulphide bond was introduced between the residues 100 and 148, S100C/N148C (DS1 mutant). The presence of this covalent cross-link leads to a 5$\sp\circ$C increase in the melting point of the protein, as verified by differential scanning calorimetry. Introduction of another disulphide bond in a similar p

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28

Spiro, Simon George. "The mechanism of action of iminosugars as antiretrovirals." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7fc4ae01-bdec-49d0-afec-e0f3e9e8f41d.

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29

Rotjanapun, Kunjana. "Dietary components and cancer risk : mechanism of action." Thesis, University of Reading, 2017. http://centaur.reading.ac.uk/75144/.

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Colon cancer is the third most diagnosed type of cancer globally and prostate cancer is the most common type of cancer in men. Consumption of diets containing fruits and vegetables is associated with a reduction in risk of both types of cancer. This may be due to the presence of various beneficial bioactive compounds and micronutrients in these foods. The precise mechanism(s) of protection are not well characterised. In this thesis, I focused on the anti-cancer effect of blueberry polyphenols on models of colon and prostate cancer. I hypothesised that the parent phytochemicals present in blueb

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30

Frith, Julie C. "Studies into the mechanism of action of clodronate." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299577.

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31

Martin, Duncan J. "Mechanism of action of the anticonvulsant drug gabapentin." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395181.

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In this study, the whole-cell patch clamp technique and Fura-2 calcium (Ca<sup>2+</sup>) imaging techniques were employed to investigate the involvement of voltage activated calcium currents (VACCs) in the mechanism of action of the anticonvulsant drug gabapentin. Molecular biology studies were also carried out to assess which VACC subunits were required for drug sensitivity in particular cell cultures. Also investigated were the effects, if any, of gabapentin at GABA receptors and on cells of the F11 line. Voltage activated calcium currents were activated in cultured DRG neurones until a cons

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32

Churcher, Mark Jonathan. "Studies on the mechanism of action of Tat." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359975.

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33

Hurley, Laurence H. "Biosynthesis and mechanism of action of antitumor antibiotics." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760690.

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34

Nawaz, Zafar. "Molecular Mechanism of Action of Steroid Hormone Receptors." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc798398/.

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A novel bacterial expression system that is capable of producing high levels of soluble, stable, biologically active human vitamin D3 and estrogen receptors has been developed. The method utilizes ubiquitin fusion technology and a low temperature nalidixic acid induction of the lambda PL promoter. This system can produce large quantities of receptor antigen, but only a small fraction displays wild-type DNA and hormone binding properties. Therefore, the use of this system to overproduce receptors for crystallization studies is not practical. To overcome these problems, a 2 um based ubiquitin fu

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35

Wong, Tin Lok. "Mechanism of action of silicon in cell signalling." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709339.

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36

Pua, Khian Hong. "Investigating the Mechanism of Action of Sanglifehrin A." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467488.

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Macrocyclic natural products occupy a special niche in the small molecule chemical space. Compared with other classes of small molecules, their larger size and conformational flexibility confer a higher propensity to recognize relatively flat surfaces that are predominant in protein-protein interactions. They are also thought to be the smallest examples of biomolecules that display functional sub-domains. Examples in this class of compounds are the immunosuppressants cyclosporine A (CSA), FK506, rapamycin (RAP) and sanglifehrin A (SFA) – the subject of this dissertation. Aside from their ther

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37

Shrestha, Sanjib K. "Novel Aminoglycosides: Bioactive Properties and Mechanism of Action." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/2073.

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Fungicide discovery is relatively neglected when compared to the investment in the development of antibacterial, antiviral, and anti-cancer therapeutics. Due to extensive use of currently available fungicides in agriculture and medicine, resistance is emerging among plant and animal pathogenic fungi. This necessitates the search for novel antifungal agents that are effective and less toxic and that do not promote resistance. FG08 and K20 are novel aminoglycoside analogs synthesized from kanamycin B and A, respectively. The antimicrobial properties of these analogs were tested in vitro against

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38

Ashraf, Sadia. "Study of mechanism of action of Scorpion neurotoxins." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423586.

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Summary Scorpions are important representative of arthropods. They have been well adapted to the extremes of environmental conditions. Scorpions also play a vital role in ecological systems by maintaining balance between different populations in an ecosystem. Apart from their positive role scorpions are responsible for more than 1.2 million stings per year with almost 3000 deaths worldwide per year and thus posing serious threat to public health. Two families of scorpions i.e. Buthida and Hemiscorpiidae are dangerous for humans. Scorpion sting can result in mild effects of redness and pain t

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39

Poon, Ming-see Angela. "Binding of 2[125I]iodomelatonin in the guinea pig spleen : evidence for a direct action of melatonin on the mammalian immune system /." [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13705556.

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40

Salazar, Montoya Vivian Angélica. "Exploring the mechanism of action of human antimicrobial ribonucleases." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/310611.

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Las ribonucleases humanas son un grupo heterogéneo de proteínas pertenecientes a la superfamilia de la Ribonucleasa A. Estas proteínas se caracterizan por su capacidad de hidrolizar ácidos ribonucleicos y por la presencia de actividad antimicrobiana frente diversos organismos patógenos como bacterias, hongos, parásitos y virus. El primer objetivo del presente estudio doctoral se centra en la caracterización de la actividad antimicrobiana y en modelos de membrana de las formas nativas de la ribonucleasa 3 purificadas a partir de eosinófilos. Las distintas formas nativas presentan modific

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41

Sardari, Lodriche Soroush. "Natural antifungals, screening, isolation, synthesis, and mechanism of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0006/NQ29103.pdf.

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42

Pirola, Byron Antony. "Structure and mechanism of action of 5-aminolevulinate synthase /." Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09php671.pdf.

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43

Barbara, Jeffrey A. J. "The mechanism of action of tumour necrosis factor-[alpha] /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phb229.pdf.

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44

Massignani, Marzia. "Polymersomes for intracellular delivery : mechanism of action and applications." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555130.

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The cell cytosol and the different subcellular organelles house the most important biochemical processes that control cell functions. Effective delivery of bioactive agents within cells is expected to have an enormous impact on both gene therapy and the future development of new therapeutic and/or diagnostic strategies based on single cell bioactive agent interactions. The main aim of this project was the evaluation of pH sensitive polymersomes made of poly(2-(methacryloyloxy)ethyl phosphorylcholine)-poly(2- (diisopropylamino)ethyl methacrylate) (PMPC-PDPA) block copolymer as a potential vecto

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45

Matthews, Charles S. "Investigations into the mechanism of action of antitumour quinols." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659198.

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Antitumour quinols containing the 4-hydroxycyclohexa-2,5-dienone pharmacophore potently inhibit human tumour cell growth in vitro and in vivo. This activity is postulated to occur via inhibition of the thioredoxin/thioredoxin reductase (TrxlTrxR) redox system which reduces numerous substrates involved in cellular proliferation, signal transduction, redox homeostasis and apoptosis. Similar to the archetypal quinol, PMX 464, its eventual successor, PMX 290, induced caspase-dependent apoptosis, cell cycle arrest and oxidative stress in sensitive tumour cells whilst depletion of glutathione increa

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46

Lewis, John. "Mechanism of action of overbased additives in hydrocarbon media." Thesis, University of East Anglia, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280936.

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47

Watson, Jeannette Moira. "5-HT autoreceptors : pharmacological characterisation and mechanism of action." Thesis, University of Hertfordshire, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275119.

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48

Gudgeon, M. C. "Studies on the mechanism of action of cyclosporin A." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378279.

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49

Romero-Canelón, Isolda. "Design and mechanism of action of organometallic anticancer complexes." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/55211/.

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Since the discovery of cisplatin, numerous attempts have been made to emulate its activity while reducing its collateral toxicity. Coordination complexes based on a wide number of transition metals have been developed in the search for improved bioavailability, selectivity and reduced adverse side-effects. Ruthenium(II) complexes have been widely developed in this field as a viable alternative to platinum chemotherapeutics. This thesis is concerned with the synthesis, characterization and biological evaluation of three series of novel half-sandwich complexes of the general formula [RuII(arene)

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50

Ooi, Nicola Chooi Twan. "Antibacterial activity and mechanism of action of lipophilic antioxidants." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5905/.

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The emergence and spread of antibiotic resistance hampers effective treatment of bacterial infections. This is particularly the case for infections involving a biofilm component, as the activity of existing antibacterial drugs against these surface-attached communities is limited. The work presented in this thesis sought to identify and characterise compounds with antibacterial and antibiofilm activity against the important pathogen, Staphylococcus aureus. Antistaphylococcal activity was assessed for 16 antioxidants that are used in cosmetics, traditional medicines or as food additives, and wh

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