Academic literature on the topic 'Mechanism of aromatic nucleophilic'

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Journal articles on the topic "Mechanism of aromatic nucleophilic"

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Nudelman, Norma Sbarbati, Cecilia E. Silvana Alvaro, Monica Savini, Viviana Nicotra, and Jeannette Yankelevich. "Effects of the Nucleophile Structure on the Mechanisms of Reaction of 1-Chloro-2,4-dinitrobenzene with Aromatic Amines in Aprotic Solvents." Collection of Czechoslovak Chemical Communications 64, no. 10 (1999): 1583–93. http://dx.doi.org/10.1135/cccc19991583.

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The kinetics of reactions of 1-chloro-2,4-dinitrobenzene with aniline and several substituted aromatic amines, B, in toluene shows a quadratic dependence of the second-order rate constant, kA, on [B], which is preserved even in the presence of increasing amounts of dimethylaniline, while the reaction with N-methylaniline shows a linear dependence of kA vs [B]. All these results are interpreted by the "dimer nucleophile" mechanism, and confirmed by the effects of a non-nucleophilic hydrogen bond acceptor tertiary amine which show the relevance of the structure of the nucleophile and the role of
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Lu, Xiaosong, and John Warkentin. "Mechanism of ipso aromatic substitution by reaction of aryloxy(methoxy)carbenes and diaryloxycarbenes with DMAD." Canadian Journal of Chemistry 79, no. 4 (2001): 364–69. http://dx.doi.org/10.1139/v01-029.

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Some aryloxy(methoxy)carbenes and diaryloxycarbenes attack dimethyl acetylenedicarboxylate (DMAD) with aryl group transfer to an alkyne carbon of DMAD. In this study diaryloxycarbenes with different aryl groups that could be transferred competitively, were generated in the presence of DMAD to probe for the mechanism of that ipso aromatic substitution. It was found that a para electron-withdrawing substituent, relative to an electron-donating substituent, facilitated migration of an aryl group. Mechanisms in accord with these findings involve initial nucleophilic attack by the carbene at an alk
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Mąkosza, Mieczysław. "How Does Nucleophilic Aromatic Substitution in Nitroarenes Really Proceed: General Mechanism." Synthesis 49, no. 15 (2017): 3247–54. http://dx.doi.org/10.1055/s-0036-1588444.

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On the basis of previously published experimental studies and ab initio calculations, a general corrected mechanism of nucleophilic aromatic substitution was formulated. It was shown that conventional nucleophilic substitution of halogens is a slow secondary reaction whereas nucleophilic substitution of hydrogen is the fast primary process. The general mechanism embraces both of these alternative and complementary reactions.
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Onuoha, Goddy N., Ikenna Onyido, and Jack Hirst. "Mechanism of aromatic nucleophilic substitution in aprotic solvents." Journal of the Chemical Society, Perkin Transactions 2, no. 6 (1988): 971. http://dx.doi.org/10.1039/p29880000971.

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Sharma, Nishant, Rupayan Biswas, and Upakarasamy Lourderaj. "Dynamics of a gas-phase SNAr reaction: non-concerted mechanism despite the Meisenheimer complex being a transition state." Physical Chemistry Chemical Physics 22, no. 45 (2020): 26562–67. http://dx.doi.org/10.1039/d0cp05567k.

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Marquet, Jorge, Francisco Casado, Maria Cervera, et al. "Reductively activated 'polar' nucleophilic aromatic substitution. A new mechanism in aromatic chemistry?" Pure and Applied Chemistry 67, no. 5 (1995): 703–10. http://dx.doi.org/10.1351/pac199567050703.

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Newmark, H. L. "Plant phenolics as inhibitors of mutational and precarcinogenic events." Canadian Journal of Physiology and Pharmacology 65, no. 3 (1987): 461–66. http://dx.doi.org/10.1139/y87-079.

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Initiation of chemical carcinogenesis involves the intracellular formation of a highly reactive electrophile that can attack many chemical nucleophiles in the cell, including DNA, a process that seems to be a central mechanism of initiation. Competing chemical nucleophiles in the cell, such as endogenous glutathione, can act as protecting or blocking agents against the attack on DNA. There are chemical substances in our food supply that may act as anticarcinogens or antimutagens by blocking or trapping ultimate carcinogen electrophiles in a nucleophilic chemical reaction, to form innocuous pro
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Chupakhin, Oleg N., and Valery N. Charushin. "Nucleophilic C–H functionalization of arenes: a new logic of organic synthesis." Pure and Applied Chemistry 89, no. 8 (2017): 1195–208. http://dx.doi.org/10.1515/pac-2017-0108.

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AbstractDirect metal-free C–H functionalization of arenes with nucleophiles is a new chapter in the chemistry of aromatics. Comprehensive studies on nucleophilic substitution of hydrogen in arenes (the SNH reactions), including mechanisms, intermediates, mathematic and electrochemical modeling, kinetics, electron-transfer, etc. have shown that this is not the hydride ion, but C–H proton is departed, and this process is facilitated by the presence of an appropriate oxidant or an auxiliary group. The SNH reactions, as a part of the general C–H functionalization concept, change the logic of organ
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Gazitúa, Marcela, Ricardo A. Tapia, Renato Contreras, and Paola R. Campodónico. "Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids." New J. Chem. 38, no. 6 (2014): 2611–18. http://dx.doi.org/10.1039/c4nj00130c.

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Tanaka, Kiyoshi, Makoto Deguchi, and Satoru Iwata. "Ab initio Study of Nucleophilic Aromatic Substitution of Polyfluorobenzene." Journal of Chemical Research 23, no. 9 (1999): 528–29. http://dx.doi.org/10.1177/174751989902300905.

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Calculations at ab initio levels of theory of the nucleophilic aromatic substitution of pentafluoronitrobenzene with amines demonstrate an addition–elimination mechanism (SNAr), with the rate-determining step at the second transition state involving C–F bond breaking, and support the ortho-selectivity of the reactions based on the stability of the second transition states.
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Dissertations / Theses on the topic "Mechanism of aromatic nucleophilic"

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Zheng, Huaiben. "Kinetics and mechanism of the hydrolysis and nucleophilic attachment/substitution of transition metal carbene complexes : kinetics of carbon proton transfers that lead to aromatic anions /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2006. http://uclibs.org/PID/11984.

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Thompson, Claire. "Aromatic nucleophilic nitration." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390199.

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Kennedy, R. J. "Copper-promoted nucleophilic aromatic substitution." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355148.

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Clough, Robert Steven. "The synthesis of aromatic polyethers by aromatic nucleophilic substitution." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057072167.

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Jones, Craig Warren. "Nucleophilic aromatic substitution using supported copper(I) reagents." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236184.

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Martin, Peter Arnold. "Nucleophilic substitution reactions of some polyhalogenated compounds." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6876/.

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Rate measurements for the reactions of a series of polyfluoro - and polychloro - pyridines with aniline and ammonia in 60/40 dioxan/water at 25ºC has shown that chlorine, when ortho and para to the position of attack, is activating with respect to fluorine, but at the position meta to the point of attack, chlorine and fluorine are virtually equivalent in their effect on reaction rate. The trifluoromethyl and nitrile groups were found to be activating relative to fluorine when ortho and para to the position of substitution and the nitrile group was thus found to be ortho/para directing. The ort
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Shen, Bin. "Studies on the nucleophilic aromatic 18 F-Fluorination from model compounds to aromatic amino acids /." [S.l. : s.n.], 2008.

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Stevens, James Andrew. "Structure-reactivity patterns in nucleophilic addition to activated aromatic compounds." Thesis, Durham University, 1990. http://etheses.dur.ac.uk/6217/.

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Kinetic and equilibrium data for the reactions of some aromatic nitro compounds with nucleophiles have been investigated using various spectrophotometric techniques (UV/visible, stopped-flow and temperature jump) and nmr spectroscopy. Kinetic and equilibrium data are reported for the formation of 1:1 and 1:2 adducts in aqueous solutions from 1,3,5-trinitrobenzene (TNB) and 2,4,6-trinitro- toluene (TNT) with thiolate ions derived from thioglycolic acid, thiomalic acid and glutathione. The results are used to determine intrinsic reactivities, kg, for the thiolate ions in adduct-forming reactions
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Giles, Robert G. "Some reactions of acyl cation equivalents with nucleophilic aromatic systems." Thesis, Loughborough University, 1986. https://dspace.lboro.ac.uk/2134/11087.

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Trimethyloxonium fluoroborate rapidly reacts with nitriles at elevated temperatures, to afford N-methylnitrilium salts. Subsequent reaction with π-excessive heterocyclic aromatic systems has been shown to give rise to iminium salts in moderate to excellent yields. The related imines may be obtained by deprotonation, and these compounds can be converted further by reduction or hydrolysis to secondary amines or ketones respectively. The reactions studied provide access to acylated indoles and pyrroles which are obtainable by other methods in inferior yields. The related reactions with carbocycli
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Lau, J. C. Y. "The mechanism of nucleophilic substitution at silicon." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374491.

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Books on the topic "Mechanism of aromatic nucleophilic"

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Terrier, François. Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527656141.

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N, Charushin Valery, and Plas, H. C. van der., eds. Nucleophilic aromatic substitution of hydrogen. Academic Press, 1994.

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Russia) Konferent͡sii͡a Aromaticheskoe nukleofilʹnoe zameshchenie (1989 Novosibirsk. Konferent͡sii͡a Aromaticheskoe nukleofilʹnoe zameshchenie: Tezisy dokladov. Novosibirskiĭ in-t organicheskoĭ khimii SO AN SSSR, 1989.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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Hardee, David James. Part 1 : Lanthanum Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer. Part 2: Reaction Design with Aromatic Ions - Nucleophilic Acyl Substitution and Organophotoredox Catalysts. [publisher not identified], 2011.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Limited, John, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Book chapters on the topic "Mechanism of aromatic nucleophilic"

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470975800.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2008. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms 2001. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470866748.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119941910.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470022051.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2006. John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470669587.ch5.

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Arican, Yagmur Emre. "Polycyclic Aromatic Hydrocarbons (PAHs)." In Food Safety. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358787.16.

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Polycyclic aromatic hydrocarbons (PAHs) are toxic substances that undergo bioaccumulation and can be found in various forms, including coal tar, fossil fuel burning, forest fires, grilling meats over open fires, cigarette smoke, diesel emissions, asphalt surfaces, tar roofs, aluminum and coke plants, and more. PAHs can initiate and promote tumors and may function as complete carcinogens, resulting in a high occurrence of tumors and mortality in laboratory animals. Exposure to PAHs can occur at home, outdoors, or at work, with a mixture of PAHs being more likely. Primary sources of exposure to
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Esikova, I. A. "Nucleophilic aliphatic and aromatic substitution in phase transfer catalysis: mechanisms and synthetic applications." In Handbook of Phase Transfer Catalysis. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-0023-3_1.

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Conference papers on the topic "Mechanism of aromatic nucleophilic"

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Lyu, Wenyao, and Federico Galvanin. "Automated Identification of Kinetic Models for Nucleophilic Aromatic Substitution Reaction via DoE-SINDy." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.107548.

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Nucleophilic aromatic substitutions (SNAr) are key chemical transformations in pharmaceutical and agrochemical synthesis, yet their complex mechanisms (concerted or two-step) complicate kinetic model identification. Accurate kinetic models for SNAr are essential for scale-up, optimization, and control of the reaction process, but conventional methods struggle with mechanism uncertainty driven by substrates, nucleophiles, and reaction conditions, with data collection being difficult due to its source-intensive nature. We address this using DoE-SINDy, a data-driven framework for generative model
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Hamza, Ameer, and Rakan M. Samman. "Corrosion Challenges in Aromatic Extraction Unit." In MECC 2023. AMPP, 2023. https://doi.org/10.5006/mecc2023-20253.

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Abstract Extraction units are typically utilizing the solvents to dissolve the aromatics compounds such as benzene, toluene, and xylenes from hydrocarbon stream. These solvents are organo-sulfur compound which is readily soluble in the water due to high polarity of oxygen-sulfur compounds. Fresh solvents are not considered to be corrosive for carbon steel and stainless-steel components, however improper application and handling of this solvents will result in degradation of this products. The degradation is basically occurring due to various factors such as solvent from upstream units, reactio
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Méndez, Conception, Simona Duplat, Sandra Hernández, and José Vera. "On the Mechanism of Corrosion Inhibition by Crude Oils." In CORROSION 2001. NACE International, 2001. https://doi.org/10.5006/c2001-01030.

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Abstract Some Venezuelan crude oils have shown exceptional inhibition of sulfide stress corrosion cracking susceptibility and general corrosion in carbon steels, even up to 99 % water cut. The inhibition mechanism of a specific crude oil was studied and the effect of saturate, aromatic and resin fractions separated from the crude oil was evaluated. Results from electrochemical impedance spectroscopy, complemented with chemical analysis of electrode surface, corrosion products and crude oil fractions were consistent with an adsorption model for corrosion inhibition.
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Méndez, Conception, Simona Duplat, Sandra Hernández, and José Vera. "On the Mechanism of Corrosion Inhibition by Crude Oils." In CORROSION 2001. NACE International, 2001. https://doi.org/10.5006/c2001-01044.

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Abstract Some Venezuelan crude oils have shown exceptional inhibition of sulfide stress corrosion cracking susceptibility and general corrosion in carbon steels, even up to 99 % water cut. The inhibition mechanism of a specific crude oil was studied and the effect of saturate, aromatic and resin fractions separated from the crude oil was evaluated. Results from electrochemical impedance spectroscopy, complemented with chemical analysis of electrode surface, corrosion products and crude oil fractions were consistent with an adsorption model for corrosion inhibition.
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Alink, B., B. Outlaw, V. Jovancicevic, S. Ramachandran, and S. Campbell. "Mechanism of CO2 Corrosion Inhibition by Phosphate Esters." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99037.

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Abstract The mechanisms of corrosion inhibition of mild steel by phosphate esters in a CO2 containing environment is studied by using various inhibitor solution characterization techniques (residual analysis, dynamic surface tension, emulsion tendency). Corrosion inhibition and inhibitor film persistancy is monitored over time by using a rotating cylinder electrode (RCE) system and linear polarization resistance (LPR) technique. Corrosion rate-time/concentration profiles are obtained for all phosphate esters studied. Optical profilometry is used to assess surface microstructure as related to i
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Hollander, Orin, and Betz Industrial. "Structure-Activity Relationships of Triazole Copper-Corrosion Inhibitors: Rational Development of Enhanced Activity Inhibitors." In CORROSION 1989. NACE International, 1989. https://doi.org/10.5006/c1989-89455.

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Abstract A review of the chemistry of the aromatic triazoles and their behavior as copper corrosion inhibitors in aqueous systems is presented. Particular emphasis is placed on structure-activity relationships. Models of the inhibitive mechanism are discussed, and a new, alternative theory for the bonding of these compounds to the substrate is proposed. Applying this theory, a new inhibitor was developed, which had a greater overall inhibitive effect, but more importantly, a stronger bond to the substrate. This increase in the bond strength improved the durability of the film more than 50-fold
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Kumar, Dharmendr, Vinay Jain, and Beena Rai. "Understanding the Role of Various Functional Groups in a Molecule on Its Corrosion Inhibition Performance Using Density Functional Theory - the Case of trans-Cinnamaldehyde as an Excellent Inhibitor for Steels." In CONFERENCE 2023. AMPP, 2023. https://doi.org/10.5006/c2023-19538.

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Abstract We have investigated the role of various structural fragments, viz. C=C, C=O and the aromatic benzene ring present in trans-cinnamaldehyde (TCA) on its inhibition performance using density functional theory (DFT). For this purpose, the adsorption behavior of 2-methylbutanal (2MB), benzene (BZ), crotonaldehyde (CA), and trans-cinnamaldehyde (TCA) on Fe (001) surface were investigated. The quantum chemical descriptors and computed adsorption energies indicate that the inhibition efficiencies vary in the following order: 2MB< CA <TCA. Additionally, a deeper analysis of adso
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Monisha, R., Sowmya Ramkumar, and D. Nalini. "Experimental and Density Function Theory Calculations to Investigate the Adsorption of an Anti-inflammatory Drug on Aluminum Surface in Acid Solution." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07517.

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Abstract The literature dealing with aluminium behavior in acid media in the presence of an anti-inflammatory drug is studied in order to understand its action mechanism, protective film formed and the possibility of its application according to the inhibition efficiency achieved. Aceclofenac, an anti-inflammatory drug is studied and its inhibitive performance on aluminium corrosion was studies by both dry and wet lab studies. Dry lab process using DFT is used to explore the relationship between the inhibitor molecular property and its inhibition efficiency. Wet lab studies have been carried o
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Kumar, Dharmendr, Venkata Muralidhar K., Vinay Jain, Beena Rai, and Jeremy Moloney. "Mechanistic Insights into 2-Mercaptoethanol and Thioglycolic Acid Corrosion Inhibitor Chemistries for Mild Steel: DFT and Experimental Investigations." In CONFERENCE 2025. AMPP, 2025. https://doi.org/10.5006/c2025-00518.

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Abstract Sulfur-containing corrosion inhibitors (CIs), such as 2-mercaptoethanol (2ME), thioglycolic acid (TGA), and sodium thiosulfate (STS), are extensively used in oilfield formulations, often in conjunction with other chemistries like quaternary ammonium compounds, imidazolines, and aromatic amines, to mitigate steel corrosion in carbon dioxide environments. These sulfur-based CIs are favored for their effectiveness, low cost, and synergy with other chemistries. To optimize these formulations—by improving performance, reducing costs, and enhancing sustainability—there is a need to better u
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VO-THANH, Giang, and Alain PETIT. "Solvent-Free Microwaves Assisted Amination of Haloarenes by Aromatic Nucleophilic Substitution." In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00763.

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Reports on the topic "Mechanism of aromatic nucleophilic"

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Levy, Maggie, Raymond Zielinski, and Anireddy S. Reddy. IQD1 Function in Defense Responses. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7699842.bard.

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The main objective of the proposed research was to study IQD1's mechanism of action and elucidate its role in plant protection. Preliminary experiments suggest that IQD1 binds CaM in a Ca²⁺-dependent manner and functions in general defense responses. We propose to identify proteins and genes that interact with IQD1, which may provide some clues to its mechanism of action. We also plan to dissect IQD1's integration in defense pathways and to study and modulate its binding affinity to CaM in order to enhance crop resistance. Our specific objectives were: (1) Analysis of IQD1's CaM-binding proper
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