Log in

Relevant bibliographies by topics / Mechanism of aromatic nucleophilic / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Mechanism of aromatic nucleophilic.

Dissertations / Theses on the topic 'Mechanism of aromatic nucleophilic'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Mechanism of aromatic nucleophilic.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Zheng, Huaiben. "Kinetics and mechanism of the hydrolysis and nucleophilic attachment/substitution of transition metal carbene complexes : kinetics of carbon proton transfers that lead to aromatic anions /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2006. http://uclibs.org/PID/11984.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Thompson, Claire. "Aromatic nucleophilic nitration." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390199.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Kennedy, R. J. "Copper-promoted nucleophilic aromatic substitution." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355148.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Clough, Robert Steven. "The synthesis of aromatic polyethers by aromatic nucleophilic substitution." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057072167.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Jones, Craig Warren. "Nucleophilic aromatic substitution using supported copper(I) reagents." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236184.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Martin, Peter Arnold. "Nucleophilic substitution reactions of some polyhalogenated compounds." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6876/.

Full text

Abstract:

Rate measurements for the reactions of a series of polyfluoro - and polychloro - pyridines with aniline and ammonia in 60/40 dioxan/water at 25ºC has shown that chlorine, when ortho and para to the position of attack, is activating with respect to fluorine, but at the position meta to the point of attack, chlorine and fluorine are virtually equivalent in their effect on reaction rate. The trifluoromethyl and nitrile groups were found to be activating relative to fluorine when ortho and para to the position of substitution and the nitrile group was thus found to be ortho/para directing. The ort

APA, Harvard, Vancouver, ISO, and other styles

7

Shen, Bin. "Studies on the nucleophilic aromatic 18 F-Fluorination from model compounds to aromatic amino acids /." [S.l. : s.n.], 2008.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

8

Stevens, James Andrew. "Structure-reactivity patterns in nucleophilic addition to activated aromatic compounds." Thesis, Durham University, 1990. http://etheses.dur.ac.uk/6217/.

Full text

Abstract:

Kinetic and equilibrium data for the reactions of some aromatic nitro compounds with nucleophiles have been investigated using various spectrophotometric techniques (UV/visible, stopped-flow and temperature jump) and nmr spectroscopy. Kinetic and equilibrium data are reported for the formation of 1:1 and 1:2 adducts in aqueous solutions from 1,3,5-trinitrobenzene (TNB) and 2,4,6-trinitro- toluene (TNT) with thiolate ions derived from thioglycolic acid, thiomalic acid and glutathione. The results are used to determine intrinsic reactivities, kg, for the thiolate ions in adduct-forming reactions

APA, Harvard, Vancouver, ISO, and other styles

9

Giles, Robert G. "Some reactions of acyl cation equivalents with nucleophilic aromatic systems." Thesis, Loughborough University, 1986. https://dspace.lboro.ac.uk/2134/11087.

Full text

Abstract:

Trimethyloxonium fluoroborate rapidly reacts with nitriles at elevated temperatures, to afford N-methylnitrilium salts. Subsequent reaction with π-excessive heterocyclic aromatic systems has been shown to give rise to iminium salts in moderate to excellent yields. The related imines may be obtained by deprotonation, and these compounds can be converted further by reduction or hydrolysis to secondary amines or ketones respectively. The reactions studied provide access to acylated indoles and pyrroles which are obtainable by other methods in inferior yields. The related reactions with carbocycli

APA, Harvard, Vancouver, ISO, and other styles

10

Lau, J. C. Y. "The mechanism of nucleophilic substitution at silicon." Thesis, Open University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374491.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Antonsson, Rositha. "Nucleophilic aromatic substitutions using ethyl 3-mercaptopropionate as nucleophile : Scope and limitations." Thesis, Södertörn University College, School of Life Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1517.

Full text

Abstract:

<p>The scope and limitations of nucleophilic substitutions of aryl halides have been studied using ethyl 3-mercaptopropionate as nucleophile and microwave heating. A diversity of aromatic compounds have been investigated according to different types of leaving groups, regio isomers and substituents. Experimental design has been used as a tool to optimize the reaction. An electron-withdrawing group in ortho or para position of the leaving group proved to be necessary for a positive outcome of the reaction. Fluorine was, without competition, the best leaving group. Some examples of how the synth

APA, Harvard, Vancouver, ISO, and other styles

12

Iacono, Scott Thomas. "Semifluorinated polymers via cycloaddition and nucleophilic addition reactions of aromatic trifluorovinyl ethers." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1211387368/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Donham, Leah L. "Gas-Phase Studies of Nucleophilic Substitution Reactions: Halogenating and Dehalogenating Aromatic Heterocycles." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5645.

Full text

Abstract:

Halogenated heterocycles are common in pharmaceutical and natural products and there is a need to develop a better understanding of processes used to synthesize them. Although the halogenation of simple aromatic molecules is well understood, the mechanisms behind the halogenation of aromatic heterocycles have been more problematic to elucidate because multiple pathways are possible. Recently, new, radical-based mechanisms have been proposed for heterocycle halogenation. In this study, we examine and test the viability of possible nucleophilic substitution, SN2@X, mechanisms in the halogenat

APA, Harvard, Vancouver, ISO, and other styles

14

Awais, Ramla Osman. "Nucleophilic fluorination of aromatic esters via iodonium salts for applications in medical imaging." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509674.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Smith, Philip Henry Gaunt. "An investigation of the preparation of heterocyclic ring systems via intramolecular nucleophilic aromatic substitution." Thesis, Loughborough University, 1985. https://dspace.lboro.ac.uk/2134/10458.

Full text

Abstract:

Heterocyclic synthesis via processes involving single electron transfer, namely aromatic SRN1 ,reactions and copper metal- and cuprous halide-promoted substitutions have been investigated. The cyclisation step in all the 'syntheses is effected by an intramolecular aromatic nucelophilic substitution on a halogen atom which is ortho to the side chain bearing the nucleophilic species (generally an amide or thioamide moiety). The process of entrainment has been shown to be a valuable technique for effecting reactions performed' under SRN1 conditions. The mechanisms of, and the mechanistic relation

APA, Harvard, Vancouver, ISO, and other styles

16

Serve', Brian J. "RUTHENIUM-MEDIATED NUCLEOPHILIC AROMATIC SUBSTITUTION OF HALOGENS ON BENZENE SYSTEMS: SYNTHESIS OF 1,3,5-TRIAMINOBENZENES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152813193.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Schory, David Henry. "Quantum Chemical Investigations of Nucleophilic Aromatic Substitution Reactions and Acid Dissociations of Aliphatic Carboxylic Acids." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1253480264.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sawadjoon, Supaporn. "Palladium-Catalyzed Nucleophilic Substitution of Alcohols : Mechanistic Studies and Synthetic Applications." Doctoral thesis, Uppsala universitet, Syntetisk organisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209541.

Full text

Abstract:

This thesis deals with the palladium-catalyzed nucleophilic substitution of π-activated alcohols in which the C–O bond of a non-manipulated hydroxyl group is cleaved. The thesis is divided in two chapters describing two different catalytic systems. Chapter 2 describes a heterogeneous palladium-catalyzed transfer hydrogenolysis of primary, secondary, and tertiary benzylic alcohols to generate the corresponding aromatic hydrocarbons using formic acid as the hydrogen donor. A detailed mechanistic investigation of this reaction has been conducted that establish the kinetic order of each reaction c

APA, Harvard, Vancouver, ISO, and other styles

19

Liu, Jiangqiong. "Kinetic Studies of 6-Halopurine Nucleoside in SNAr Reactions; 6-(Azolyl, Alkylthio and Fluoro)-purine Nucleosides as Substrates for Suzuki Reactions." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1821.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Jones, Jason Robert. "Mechanism, catalysis and control in aromatic diazonium ion chemistry." Thesis, University of York, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306605.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Balasubramanian, Shankar. "Studies on the reaction mechanism of chorismate synthase." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386780.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Murray, Tracey Arnold. "Mechanism of flavin cofactor binding to flavodoxins: the role of aromatic residues and the aromatic gate." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1060639958.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Murray, Tracey Arnold. "Mechanism of flavin cofactor binding to flavodoxins: the role of aromatic residues and the aromatic gate." Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1060639958.

Full text

Abstract:

Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 153 p.; also includes graphics. Includes abstract and vita. Advisor: Richard P. Swenson, Dept. of Biochemistry. Includes bibliographical references (p. 144-153).

APA, Harvard, Vancouver, ISO, and other styles

24

Parker, David J. "Modelling nucleophilic substitution at main group elements by NMR spectroscopy and X-ray crystallography." Thesis, Open University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363493.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Leeming, S. W. "An investigation of those structural features necessary for copper-promoted nucleophilic substitution of aromatic halogen compounds by cyanide ion." Thesis, University of Kent, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373239.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Xue, Xiang. "Mechanistic studies on the thermal cyclodehydrogenations of polycyclic aromatic hydrocarbons." Thesis, Boston College, 2008. http://hdl.handle.net/2345/22.

Full text

Abstract:

Thesis advisor: Lawrence T. Scott<br>Thermal cyclodehydrogenation is the key step in the total synthesis of fullerene C60 and represents an important family of carbon-carbon bond-forming reactions. My research focuses on understanding the mechanism of C-C bond formation in the high temperature cyclodehydrogenations of PAHs using appropriate test cases to form 5- or 6-membered rings. My goal was to understand more about molecular reactions under extreme conditions and thereby realize new synthetic pathways for new molecules. This dissertation describes the synthesis of several substrates and st

APA, Harvard, Vancouver, ISO, and other styles

27

Wang, Yongfeng. "SYNTHESIS AND STRUCTURE-PROPERTY STUDIES OF ORGANIC MATERIALS CONTAINING FLUORINATED AND NON-FLUORINATED # SYSTEMS (SMALL MOLECULES AND POLYMERS)." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/593.

Full text

Abstract:

Loline alkaloids (LA) are secondary metabolites produced by Epichloandamp;euml; (anamorph, Neotyphodium) grass endophytes. They are toxic and deterrent to a broad range of herbivorous insects but not to livestock. This protective bioactivity has spurred considerable research into the LA biosynthetic pathway. LOL, the gene cluster containing nine genes, is required for LA biosynthesis. The regulation of LOL genes during LA production in culture and in symbio is of interest. In this study, coordinate regulation between LOL gene expression and LA production level was investigated in both MM cultu

APA, Harvard, Vancouver, ISO, and other styles

28

Moagi, Kgotso Herbet. "Reaction Mechanism of 2-monosubstituted Quinoxalines with Organolithium Compounds : a Theoretical Study." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75182.

Full text

Abstract:

This dissertation describes the density functional theory (DFT) computational modelling of reactions between organolithium nucleophiles and various substituted quinoxalines. These reactions result in the functionalisation of the C (sp2)–H bond, thus substituting the sigma-hydrogen. The reactions are known as nucleophilic substitution of hydrogen (SNH) and are used by experimental chemists to form new C–C bonds. The SNH reactions are very important in various industries, e.g. in designing and manufacturing of pharmaceuticals. Quinoxaline is widely used in medicinal chemistry due to its various

APA, Harvard, Vancouver, ISO, and other styles

29

Buquoi, John Quentin III. "Exploration Using Reaction Temperature to Tailor the Degree of Order in Micro-Block Copolymer Proton Exchange Membranes." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1274493418.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Saha, Biswajit, Stephan Irle, and Keiji Morokuma. "Formation mechanism of polycyclic aromatic hydrocarbons in benzene combustion: Quantum chemical molecular dynamics simulations." American Institute of Physics, 2010. http://hdl.handle.net/2237/14160.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

MacMillar, Susanna. "Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis (AUU), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7441.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Mimura, Koichi. "Synthesis of Polycyclic Aromatic Hydrocarbons from Benzene by Impact Shock: Its Reaction Mechanism and Cosmochemical Significance." Elsevier, 1995. http://hdl.handle.net/2237/15855.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Omakor, Emegbero John. "The reaction mechanism and Ã-effect in nucleophilic displacement at the phosphorus center of the pesticide, fenitrothion, by oxygen nucleophiles in aqueous medium." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22373.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Lee, Jae-kwang. "Intramolecular Charge Transfer in Dimethylaminobenzonitrile and Related Aromatic Nitriles." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1258516378.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Fetters, Hannah. "Functionalized PEEK Analogues from 2,4- and 3,5- Difluorobenzophenone Derivatives." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1559497023409191.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Labadi, Adnan Ghaleb Mohammed al. "Nucleophilic aromatic substitution by [18F]fluoride and its applications to the synthesis of model precursors for the multi-step synthesis of the PET-tracer 6-[18F]fluoro-L-DOPA." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980292638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Passeri, Sauro <1981&gt. "Study of the reaction mechanism in the alkylation of activated aromatic substrates with heterogeneous acid and basic catalysts." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1725/1/Passeri_Sauro_Tesi.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Passeri, Sauro <1981&gt. "Study of the reaction mechanism in the alkylation of activated aromatic substrates with heterogeneous acid and basic catalysts." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1725/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Chan, Mary S. W. "Factors influencing the regiochemistry of nucleophilic addition to the radical cation of alkenes and dienes studied in the context of the photochemical nucleophile-olefin combination, aromatic substitution (photo-NOCAS) reaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36574.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Nonoyama, Nobuaki. "Mechanism and Selectivity in Nitration and Side-Reactions of Aromatic and Aliphatic Compounds with Nitrogen Oxides (NO2, NO3, N2O5, ONOO-)." 京都大学 (Kyoto University), 2000. http://hdl.handle.net/2433/181133.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Gau, Jana, Paul-Georg Furtmüller, Christian Obinger, Jürgen Arnhold, and Jörg Flemmig. "Enhancing hypothiocyanite production by lactoperoxidase – mechanism and chemical properties of promotors." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206322.

Full text

Abstract:

Background: The heme enzyme lactoperoxidase is found in body secretions where it significantly contributes to the humoral immune response against pathogens. After activation the peroxidase oxidizes thiocyanate to hypothiocyanite which is known for its microbicidal properties. Yet several pathologies are accompanied by a disturbed hypothiocyanite production which results in a reduced immune defense. Methods: The results were obtained by measuring enzyme-kinetic parameters using UV–vis spectroscopy and a standardized enzyme-kinetic test system as well as by the determination of second order rate

APA, Harvard, Vancouver, ISO, and other styles

42

Silva, Gabriela Dias da. "Síntese e avaliação biológica de selenoaminas heteroarílicas : uma nova proposta quimioterápica para malária." reponame:Repositório Institucional da UFABC, 2014.

Find full text

Abstract:

Orientador: Prof. Dr. Rodrigo Luiz Oliveira Rodrigues Cunha<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Ciência & Tecnologia - Química, 2014.<br>Errata: Folha 4, linha 20. Onde se lê "Figura 1. Imagem de microscopia evidanciando o anel trofozoíta (no centro em destaque), leia-se Figura 1. Imagem de microscopia evidanciando o anel trofozoíta (no centro, em destaque). Fonte: https://pt.wikipedia.org/wiki/ficheiro:Plasmodium_ovale_01.png<br>As doenças tropicais negligenciadas (DTNs), características de regiões menos desenvolvidas do planeta com baixos nív

APA, Harvard, Vancouver, ISO, and other styles

43

Gau, Jana, Paul-Georg Furtmüller, Christian Obinger, Jürgen Arnhold, and Jörg Flemmig. "Enhancing hypothiocyanite production by lactoperoxidase – mechanism and chemical properties of promotors." Elsevier, 2015. https://ul.qucosa.de/id/qucosa%3A14827.

Full text

Abstract:

Background: The heme enzyme lactoperoxidase is found in body secretions where it significantly contributes to the humoral immune response against pathogens. After activation the peroxidase oxidizes thiocyanate to hypothiocyanite which is known for its microbicidal properties. Yet several pathologies are accompanied by a disturbed hypothiocyanite production which results in a reduced immune defense. Methods: The results were obtained by measuring enzyme-kinetic parameters using UV–vis spectroscopy and a standardized enzyme-kinetic test system as well as by the determination of second order rate

APA, Harvard, Vancouver, ISO, and other styles

44

Xie, Sheng. "Perfluroaryl azides : Reactivities, Unique Reactions and their Applications in the Synthesis of Theranostic Agents." Doctoral thesis, KTH, Organisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-172950.

Full text

Abstract:

The work centersaround perfluoroaryl azides (PFAAs), and theirability to undergo certain fast and robusttransformations. The chemistry was furtherappliedfor biomedical applications. The first section focuses on the azide-aldehyde-amine cycloaddition using PFAAs. Experimental and computational investigations uncovered a fast azide-enamine cycloaddition to form triazolines, which spontaneously rearrange into stable amidine products. In addition, this transformation was explored in the formulation of pure nanodrugs. Because this reaction can introduce a phenyl and a perfluoroaryl moiety enabling

APA, Harvard, Vancouver, ISO, and other styles

45

Pichette, drapeau Martin. "Nouvelles méthodes de synthèse pour la formation de liaisons C(aryl)-hétéroatome et C(aryl)-C par réactions de substitution nucléophile aromatique et vinylique." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCM0005.

Full text

Abstract:

L'objectif central de notre thèse de doctorat visait l'utilisation d'halogénures d'aryles en tant qu'électrophiles dans des réactions de substitution nucléophile aromatique (SNAr). D'abord, nous avons cherché à former des liaisons C(aryl) hétéroatome par réaction entre des nucléophiles hétéroatomiques et des halogénures d'aryles substitués par des groupements électro-attracteurs. Les résultats de cette étude ont été comparés à des incohérences relevées dans la littérature et montrent que l'ordre de réactivité d'halogénures d'aryles communément accepté n'est pas toujours respecté. Un effet posi

APA, Harvard, Vancouver, ISO, and other styles

46

Dehbi, Oussama. "Synthèse de nouveaux dérivés pyridopyrimidiniques, imidazopyridiniques et imidazopyridaziniques : évaluation de leurs propriétés biologiques." Thesis, Orléans, 2012. http://www.theses.fr/2012ORLE2078/document.

Full text

Abstract:

Les produits appartenant à la famille des pyridopyrimidines sont caractérisés par leur intense utilisation dans le domaine pharmacologique, ce qui a poussé différentes équipes de recherche, de par le monde, à les étudier chimiquement et biologiquement. Dans ce travail, nous nous sommes intéressés au groupe des pyridopyrimidines et, plus particulièrement, à l’isomère le moins décrit dans la littérature, à savoir les pyrido[3,2-d]pyrimidines. Les composés ciblés sont synthétisés à partir de la 2,7-dichloropyrido[3,2-d]pyrimidine, via des substitutions nucléophiles aromatiques et des couplages pa

APA, Harvard, Vancouver, ISO, and other styles

47

Speare, Damian Matthew. "Studies to elucidate the mechanism of degradation of 2-hydroxy-6-oxo-6-substituted-hexa-2,4-dienoates by MhpC and BhpD enzymes found on aromatic degradation pathways." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396860.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Pescheteau, Clémentine. "Conception et synthèse d’inhibiteurs duaux de DYRK1A et CLK1, kinases impliquées dans la maladie d’Alzheimer." Electronic Thesis or Diss., Orléans, 2021. http://www.theses.fr/2021ORLE3203.

Full text

Abstract:

La maladie d’Alzheimer est la forme de démence la plus répandue dans le monde et à ce jour, aucun traitement efficace n’existe malgré de nombreuses recherches en cours. De nouvelles stratégies thérapeutiques ont émergé, ciblant des protéines kinases impliquées dans les processus de neurodégénération et de neuroinflammation. DYRK1A et CLK1 ont notamment été identifiées comme des cibles intéressantes pour lutter contre des pathologies du système nerveux central, et sont particulièrement impliquées dans la maladie d’Alzheimer. Afin de concevoir des inhibiteurs puissants et sélectifs de ces deux k

APA, Harvard, Vancouver, ISO, and other styles

49

Sadeghipour, Mitra Jr. "Hydrocarbon Functionalization via a New Free Radical-Based Condensation Reaction." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30627.

Full text

Abstract:

A new free radical chain process for the allylation of hydrocarbons and some other substrates utilizing substituted allyl bromides (R-H + C=C-C-Br -> R-C-C=C + HBr) has been developed. Good to excellent yields were observed in all cases. Kinetic chain measurements and competition experiments were performed in order to elucidate the mechanism of the reaction. Overall, the results are consistent with a free radical chain process with bromine atom as the chain carrier. Substitution effects on the reactivity of the allyl bromides (CH2=C(Z)CH2Br) and their i

APA, Harvard, Vancouver, ISO, and other styles

50

Rather, Liv Juliane [Verfasser], and Georg [Akademischer Betreuer] Fuchs. "Structure and mechanism of benzoyl-CoA epoxidase BoxAB from Azoarcus evansii : : an elegant strategy to break the aromatic ring = Struktur und Mechanismus der Benzoyl-CoA Epoxidase BoxAB aus Azoarcus evansii." Freiburg : Universität, 2011. http://d-nb.info/1123459215/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!