Academic literature on the topic 'Mechanism Of Drug Release'

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Journal articles on the topic "Mechanism Of Drug Release"

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Chowdhury, Nargis A., John Robertson, Ahmed Al-Jumaily та Maximiano V. Ramos. "Fast Release of Sulfosalicylic Acid from Polymer Implants Consisting of Regenerated Cellulose/γ-Ferric Oxide/Polypyrrole". Journal of Applied Chemistry 2014 (22 грудня 2014): 1–7. http://dx.doi.org/10.1155/2014/474268.

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This work presents a comparative study on the rate of drug release from implantable matrices induced by electric and magnetic fields separately for better biomedical applications. The matrices were prepared by coating γ-ferric oxide dispersed regenerated cellulose film by polypyrrole doped with sulfosalicylic acid as an anti-inflammatory drug. The drug release mechanisms were studied under both the electric and the magnetic fields separately in an acetate buffer solution with pH 5.5 and temperature 37°C during a period of 5 hours. The amount of drug released was analysed by UV-Vis spectrophoto
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Kanke, Pralhad K., Pankaj Sawant, Ajit Jadhav, and Md Rageeb Md Usman. "A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 19–22. http://dx.doi.org/10.22270/jddt.v8i5.1852.

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A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of d
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Zhu, Weiwei, Jiajie Long, and Meiwu Shi. "Release Kinetics Model Fitting of Drugs with Different Structures from Viscose Fabric." Materials 16, no. 8 (2023): 3282. http://dx.doi.org/10.3390/ma16083282.

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(1) Background: It is simpler and more environmentally friendly to use supercritical CO2 fluid technology to process skincare viscose fabrics. Therefore, it is significant to study the release properties of drug-loaded viscose fabrics to choose suitable skincare drugs. In this work, the release kinetics model fittings were investigated in order to clarify the release mechanism and provide a theoretical basis for processing skincare viscose fabrics with supercritical CO2 fluid. (2) Methods: Nine kinds of drugs with different substituent groups, different molecular weights, and different substit
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Chudoba, Dorota, Monika Jażdżewska, Katarzyna Łudzik, Sebastian Wołoszczuk, Ewa Juszyńska-Gałązka, and Mikołaj Kościński. "Description of Release Process of Doxorubicin from Modified Carbon Nanotubes." International Journal of Molecular Sciences 22, no. 21 (2021): 12003. http://dx.doi.org/10.3390/ijms222112003.

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and th
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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll
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Chakraborty, Santanu, Madhusmruti Khandai, Anuradha Sharma, Ch Patra, V. Patro, and Kalyan Sen. "Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations." Acta Pharmaceutica 59, no. 3 (2009): 313–23. http://dx.doi.org/10.2478/v10007-009-0025-8.

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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied.
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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre
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Wang, Lei, and Gang Wu. "Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing." Advanced Materials Research 898 (February 2014): 300–303. http://dx.doi.org/10.4028/www.scientific.net/amr.898.300.

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A local drug delivery system constituted by hybrid microsphere/thermosensitive hydrogel was fabricated for Osteoarthritis (OA) therapy in the research. The hydrogel were synthesized by ring-opening copolymerization. Microsphere was fabricated by O/W emulsion and solution evaporation method. The properties of the products were characterized by 1HNMR, FTIR and phase transition diagram. The microsphere/hydrogel was prepared for in vitro drug release research. The results showed microsphere/hydrogel hybrid system can alleviate initial burst release. After 650 hours, only 60 percent of the drugs we
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Nagella, Sivagangi Reddy, Soojeong Choi, Soo-Yong Park, et al. "Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine." International Journal of Molecular Sciences 24, no. 22 (2023): 16470. http://dx.doi.org/10.3390/ijms242216470.

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This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH) nanogels were prepared by varying the composition of comonomers such as MMA, HEMA, and redox initiator CAN. The nanogels were then characterized using FTIR, TGA, SEM, and TEM. The CsPMH nanogels showed greater encapsulation efficiencies from 43.20–91.77%. Computational studies were also conducted to
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Al-Ali, Maha. "Comparative analyses of Weibull model and conventional kinetics models of drug release of formulated multi-component tablets." Al-Qadisiyah Journal for Engineering Sciences 18, no. 2 (2025): 107–16. https://doi.org/10.30772/qjes.2024.148019.1175.

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The Kinetics study of drug release is an essential requirement to examine the capability of the drug formulation to modulate with the typical drug release profile. In the present work, hence, Weibull model and other traditional drug release models are selected to investigate the release of tablets prepared using different drying techniques in a simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet (MVT), convective drying (CVT), freeze drying (FRT), vacuum drying (VAT), and that without drying process (NDT). This study aims to compare the W
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Dissertations / Theses on the topic "Mechanism Of Drug Release"

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Kadri, Balaji Venkataramanappa. "Mechanism of drug release from matrix tablets involving moving boundaries." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63184.pdf.

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Stenton, Benjamin James. "Metal mediated mechanisms of drug release." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284402.

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In this thesis will be described research towards the development of bioorthogonal bond-cleavage reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or "decaging" reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the incorporation of a protein modification handle which allowed an amine-bearing drug to be covalently ligated to a protein by a palladium-cleavable linker. This chemistry was demonstrated by the conjugation of the antica
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Velghe, Carine. "Oral controlled drug delivery systems, optimization of release patterns and elucidation of release mechanisms." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S048/document.

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Le développement de nouvelles formes galéniques nécessite la mise au point de protocoles avec variation d’un ensemble de paramètres jouant sur les caractéristiques du dispositif. Au niveau industriel, cela représente une perte importante de temps et d’argent. Avec le développement d’outils permettant la caractérisation des systèmes et à fortiori des mécanismes impliqués dans la libération du principe actif, l’application des modèles mathématiques se voit être de plus en plus grande permettant de prédire la sortie du principe actif hors de son système. L’un des objectifs de ce travail a été de
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Jayan, Arvind. "Investigating the drug release mechanisms of mixed HPMC/PEO hydrophilic matrices." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444075.

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Modi, Sweta. "The Critical Role of Mechanism-Based Models for Understanding and Predicting Liposomal Drug Loading, Binding and Release Kinetics." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/19.

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Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment. Membrane binding of the drug affects both dru
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Tamani, Fahima. "Towards a better understanding of the drug release mechanisms in PLGA microparticles." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S048.

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Les microparticules à base de poly (acide lactique-co-glycolique) (PLGA) représentent un choix attrayant pour le contrôle de la libération de substance active sur des périodes allant de quelques jours à plusieurs mois, tout en assurant une bonne biocompatibilité et une biodégradabilité complète. Différents types de mécanismes peuvent être impliqués dans le contrôle de la libération de substance active à partir de microparticules de PLGA, par exemple la diffusion de l’eau, la dissolution de substance actives, la diffusion de substance actives, la dégradation des polymères, l’autocatalyse et le
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Azhari, Zein. "The degradation and drug release mechanisms of poly(ethylene glycol)-functionalised poly(L-lactide) polymers." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275968.

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Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates remain limited. This work aimed to examine a consistent series of polymers based on a large block of PLLA and small quantities of hydrophilic poly(ethylene glycol) (PEG) initiator. The polymers had PLLA number average molecular weight (Mn) values ranging between about 60 kDa and 200 kDa and PEG Mns rangin
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Ellison, Mark. "An investigation of the physicochemical and rheological properties of drug-gel formulations in relation to drug release mechanisms." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361471.

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Challinor, Caron Lynn. "Characterisation and manipulation of mechanisms of controlled drug release using a heterodisperse polysaccharide matrix." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320433.

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Utting, Anita A. "Liquid filled hard gelatin capsules : an investigation of thermosoftened drug/poloxamer solid dispersion formulations in relation to drug release mechanisms." Thesis, University of Sunderland, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327315.

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Books on the topic "Mechanism Of Drug Release"

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Kadri, Balaji Venkataramanappa. Mechanism of drug release from matrix tablets involving moving boundaries. National Library of Canada, 2001.

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1954-, Grassi Mario, ed. Understanding drug release and absorption mechanisms: A physical and mathematical approach. CRC Press, 2007.

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Berlin, Freie Universität, ed. Polymeric controlled drug delivery systems: Elucidation of transport mechanisms and optimization of release patterns. [s.n.], 1999.

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Laberge, Monique. Decreased drug uptake as a mechanism of drug resistance. Laurentian University, 2006.

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1944-, Rubinstein M. H., ed. Pharmaceutical technology--controlled drug release. Ellis Horwood, 1987.

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1957-, Rathbone Michael J., Hadgraft Jonathan 1950-, and Roberts Michael S. 1949-, eds. Modified-release drug delivery technology. Marcel Dekker, 2003.

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M, Weaver Jonathan, ed. Catia V5 tutorials: Mechanism design & animation : release 19. Schroff Development Corp, 2010.

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Elguindi, Sahar. Cytotoxic and antidote mechanisms for cyanide release from various drugs and agents. National Library of Canada = Bibliothèque nationale du Canada, 1991.

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Elguindi, Sahar. Cytotoxic and antidote mechanisms for cyanide release from various drugs and agents. University of Toronto, 1990.

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Wilson, Clive G., and Patrick J. Crowley, eds. Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1.

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Book chapters on the topic "Mechanism Of Drug Release"

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Bhatta, Kalpita, Himansu Bhusan Samal, Itisum Sarangi, et al. "Release Mechanism of Smart Drug Delivery." In Smart Micro- and Nanomaterials for Pharmaceutical Applications. CRC Press, 2024. http://dx.doi.org/10.1201/9781003468431-5.

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Colombo, Paolo, Gaia Colombo, and Christine Cahyadi. "Geometric Release Systems: Principles, Release Mechanisms, Kinetics, Polymer Science, and Release-Modifying Material." In Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_11.

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Omidian, Hossein, Shahin Fesharaki, and Kinam Park. "Oral Controlled Delivery Mechanisms and Technologies." In Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_6.

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Siegel, Ronald A., and Michael J. Rathbone. "Overview of Controlled Release Mechanisms." In Fundamentals and Applications of Controlled Release Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0881-9_2.

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Liu, Xiaoxia. "Data Reconciliation of Release Mechanism Research of LDH-Based Drug." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-38715-9_63.

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El-Sherbiny, Ibrahim M., Diana G. Villanueva, Dea Herrera, and Hugh D. C. Smyth. "Overcoming Lung Clearance Mechanisms for Controlled Release Drug Delivery." In Controlled Pulmonary Drug Delivery. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-9745-6_5.

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Ma, Yanping, Yeona Kang, Angelica Davenport, Jennifer Mawunyo Aduamah, Kathryn Link, and Katharine Gurski. "Extended-Release Pre-exposure Prophylaxis and Drug-Resistant HIV." In Mathematical Modeling for Women’s Health. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-58516-6_2.

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AbstractThe pharmacologic tail of long-acting cabotegravir (CAB-LA), an injectable pre-exposure prophylaxis (PrEP), allows for months-long intervals between injections, but it may facilitate the emergence of drug-resistant human immunodeficiency virus (HIV) strains during the acute infection stage. In this chapter, we present a within-host, mechanistic ordinary differential equation model of the HIV latency and infection cycle in CD4$${ }^+$$ + T-cells to investigate the impact of CAB-LA on drug-resistant mutations in both humans and macaques. We develop a pharmacokinetic/pharmacodynamic model
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Srivastava, Madhumita, Vijaya Shukla, Shiv Nandan, Mohd Faheem Khan, and Karuna Shanker. "Update on Functional Properties and Drug Release Mechanism of Some Notable Nanofillers." In Handbook of Nanofillers. Springer Nature Singapore, 2024. https://doi.org/10.1007/978-981-99-3516-1_11-1.

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Melia, C. D., P. Marshall, P. Stark, S. Cunningham, A. Kinahan, and J. Devane. "Investigating in Vitro Drug Release Mechanisms Inside Dosage Forms." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_10.

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Fitzgerald, J. F., and O. I. Corrigan. "Mechanisms Governing Drug Release from Poly-α-Hydroxy Aliphatic Esters." In ACS Symposium Series. American Chemical Society, 1993. http://dx.doi.org/10.1021/bk-1993-0520.ch023.

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Conference papers on the topic "Mechanism Of Drug Release"

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Divetia, Asheesh, Nolan Yoshimura, Guann-Pynn Li, Baruch D. Kuppermann, and Mark Bachman. "Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38054.

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Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer u
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Srikar, R., C. M. Megaridis, A. L. Yarin, and A. V. Bazilevsky. "Desorption-Limited Mechanism of Release From Polymer Nanofibers." In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72054.

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This work examines the release of a model water-soluble compound from electrospun polymer nanofiber assemblies. Such release attracts attention in relation with biomedical applications, such as controlled drug delivery. It is also important for stem cell attachment and differentiation on biocompatible electrospun nanofiber scaffolds containing growth factors, which have been encapsulated by means of electrospinning. Typically, the release mechanism has been attributed to solid-state diffusion of the encapsulated compound from the fibers into the surrounding aqueous bath. Under this assumption,
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Mohammed, Afzal, Sheraz Khan, Hannah Batchelor, and Yvonne Perrie. "Release mechanism based on polymer-drug dissolution and stability studies of paracetamol solid dispersion." In The 2nd Electronic Conference on Pharmaceutical Sciences. MDPI, 2012. http://dx.doi.org/10.3390/ecps2012-00802.

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Vesala, Laura, Robert Perttilä, Elias Kokko, Lasse Orsila, and Petteri Uusimaa. "Light-activated drug release using an automated well plate illuminator." In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, edited by David H. Kessel and Tayyaba Hasan. SPIE, 2022. http://dx.doi.org/10.1117/12.2608745.

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Zhang, Xinqun, Nicole M. Okeley, Jocelyn Setter, et al. "Abstract 5334: Mechanism of cysteine-mcMMAF release from the stably linked antibody-drug conjugate SGN-75." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5334.

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Ma, Qin. "Analogy Between Transient Heat Conduction and Dissolution of Solid Particles in Liquids Based on the Shrinking Core Model." In ASME 2017 Heat Transfer Summer Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/ht2017-5009.

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In this study, the analogy between transient heat conduction and mass transfer is applied to investigate the dissolution behavior of solid particles in liquids, particularly, for the transport phenomenon associated with the controlled drug release process. Mathematical modeling is established assuming the shrinking core is solely caused by the diffusion mechanism. The transport governing equations for the dissolution process of controlled drug release are compared with the transient heat conduction differential equations. Analogous quantities, certain analytical solutions and numerical solutio
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Liu, Wing Kam, and Ashfaq Adnan. "Multiscale Modeling and Simulation for Nanodiamond-Based Therapeutic Delivery." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13273.

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It has been demonstrated from recent research that nanodiamond(ND)-enabled drug delivery as cancer therapeutics represents an important component of optimized device functionality. The goal of the current research is to develop a multiscale modeling technique to understand the fundamental mechanism of a ND-based cancer therapeutic drug delivery system. The major components of the proposed device include nanodiamonds (ND), parylene buffer layer and doxorubicin (DOX) drugs, where DOX loaded self-assembled nanodiamonds are packed inside parylene capsule. The efficient functioning of the device is
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Herrlich, S., S. Spieth, H. Gerstmann, et al. "Drug release mechanisms of steroid eluting rings in cardiac pacemaker lead electrodes." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346023.

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Chong, William, Mircea Teodorescu, Ashlie Martini, and Homer Rahnejat. "Mechanisms of Entrapment and Release of Fluid Droplets From Nano-Scale Surface Features." In ASME/STLE 2012 International Joint Tribology Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/ijtc2012-61201.

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Engineering surfaces are never perfectly flat. They contain micro and nano-scale features on multiple length scales. Predicting the amount of fluid trapped in these minute surface crevices and its controlled release could benefit a variety of practical applications. In a sliding contact, the released fluid could create an ultra-thin film, reducing the direct contact and consequently the boundary friction. Transdermal patches are the least invasive of available subcutaneous drug delivery techniques. The drug is stored in a micro-reservoir and it is released to the skin either through a permeabl
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Usta, Aybala, Muhammad Rahman, and Ramazan Asmatulu. "Synthesis, Stability and Selection Study of Oil-in-Water Nanoemulsions Containing Nigella Sativa L. Essential Oil." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-72205.

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Targeted drug delivery has a great importance in cancer treatment and is in interest of many scientists worldwide. Targeted drug delivery renders local treatment of cancerous cells possible without affecting healthy cells. Hydrogels are promising materials to be used in targeted drug delivery systems due to their biocompatible nature and injectable behaviors where they can be used to load drugs. However, considering that not all the drugs are water soluble, entrapment of some drugs into hydrogels is not practical in terms of poor drug solubility and burst drug release because of this. At this
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Reports on the topic "Mechanism Of Drug Release"

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Sirivat, Anuvat. Electrically controlled release of drugs from alginate hydrogels for transdermal drug delivery application. Chulalongkorn University, 2014. https://doi.org/10.58837/chula.res.2014.80.

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A drug-loaded conductive polymer/hydrogel blend, benzoic acid-loaded poly(3,4-ethylenedioxythiophene/alginate (BA-loaded PEDOT/Alg) hydrogel, was used as a carrier/matrix for an electrical stimuli transdermal drug delivery system (TDDS). The effects of crosslinking ratio, PEDOT particle size, and electric field strength on the release mechanism and the diffusion coefficient (D) of BA were examined by using a modified Franz-diffusion cell. The diffusion scaling exponent value of BA is close to 0.5 which refers to the diffusion controlled mechanism, or the Fickian diffusion as the BA release mec
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Chutimaworapan, Suchada. Fast release solid dispersion system of nifedipine. Chulalongkorn University, 1999. https://doi.org/10.58837/chula.res.1999.28.

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Abstract:
Nifedupine solid dispersions in polyethylene glycols (PEG4000 and PEG6000), poloxamers (poloxamer188 poloxamer288 and poloxamer407), [beta]-cyclodextrin (BCD) and 2-hydroxypropyl-[beta]-cyclodextrin (HPBCD), at the drug:carrier ratio if 1:1, 1:3, 1:5, and 1:10 were investigated. The systems were prepared by melting, solvent and kneading method and compared to physical mixtures. It was found that the drug:carrier ratio of 1:10 and by melting and solvent methods showed most conspicuous dissolution rates in most systems (p<0.05). The most markedly improved rate was exhibited from the poloxamer
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Fong, Kyna, and Michael Schwarz. Towards an Efficient Mechanism for Prescription Drug Procurement. National Bureau of Economic Research, 2009. http://dx.doi.org/10.3386/w14718.

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BOGER, R. M., and R. DALE. Development of the Pintle Release Fork Mechanism. Office of Scientific and Technical Information (OSTI), 1999. http://dx.doi.org/10.2172/797748.

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Buck, Edmond. Mechanism of Calcium Release from Skeletal Muscle Sarcoplasmic Reticulum. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.1306.

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Stanton, Patric K. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada607813.

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Garrido Sanabria, Emilio R. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada608027.

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Garrido-Sanabria, Emilio. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada610543.

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Stanton, Patric K. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580461.

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Garrido, Emilio R. New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada580462.

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