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Dissertations / Theses on the topic 'Mechanism Of Drug Release'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Kadri, Balaji Venkataramanappa. "Mechanism of drug release from matrix tablets involving moving boundaries." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63184.pdf.

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2

Stenton, Benjamin James. "Metal mediated mechanisms of drug release." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284402.

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In this thesis will be described research towards the development of bioorthogonal bond-cleavage reactions, and their applications in targeted drug delivery (Figure 1). The first project relates to the development of a palladium mediated bond-cleavage or "decaging" reaction which can cause a propargyl carbamate to decompose and release an amine. This was further developed by the incorporation of a protein modification handle which allowed an amine-bearing drug to be covalently ligated to a protein by a palladium-cleavable linker. This chemistry was demonstrated by the conjugation of the antica

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3

Velghe, Carine. "Oral controlled drug delivery systems, optimization of release patterns and elucidation of release mechanisms." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S048/document.

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Le développement de nouvelles formes galéniques nécessite la mise au point de protocoles avec variation d’un ensemble de paramètres jouant sur les caractéristiques du dispositif. Au niveau industriel, cela représente une perte importante de temps et d’argent. Avec le développement d’outils permettant la caractérisation des systèmes et à fortiori des mécanismes impliqués dans la libération du principe actif, l’application des modèles mathématiques se voit être de plus en plus grande permettant de prédire la sortie du principe actif hors de son système. L’un des objectifs de ce travail a été de

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4

Jayan, Arvind. "Investigating the drug release mechanisms of mixed HPMC/PEO hydrophilic matrices." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444075.

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5

Modi, Sweta. "The Critical Role of Mechanism-Based Models for Understanding and Predicting Liposomal Drug Loading, Binding and Release Kinetics." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/19.

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Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment. Membrane binding of the drug affects both dru

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6

Tamani, Fahima. "Towards a better understanding of the drug release mechanisms in PLGA microparticles." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S048.

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Les microparticules à base de poly (acide lactique-co-glycolique) (PLGA) représentent un choix attrayant pour le contrôle de la libération de substance active sur des périodes allant de quelques jours à plusieurs mois, tout en assurant une bonne biocompatibilité et une biodégradabilité complète. Différents types de mécanismes peuvent être impliqués dans le contrôle de la libération de substance active à partir de microparticules de PLGA, par exemple la diffusion de l’eau, la dissolution de substance actives, la diffusion de substance actives, la dégradation des polymères, l’autocatalyse et le

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7

Azhari, Zein. "The degradation and drug release mechanisms of poly(ethylene glycol)-functionalised poly(L-lactide) polymers." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275968.

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Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates remain limited. This work aimed to examine a consistent series of polymers based on a large block of PLLA and small quantities of hydrophilic poly(ethylene glycol) (PEG) initiator. The polymers had PLLA number average molecular weight (Mn) values ranging between about 60 kDa and 200 kDa and PEG Mns rangin

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8

Ellison, Mark. "An investigation of the physicochemical and rheological properties of drug-gel formulations in relation to drug release mechanisms." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361471.

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9

Challinor, Caron Lynn. "Characterisation and manipulation of mechanisms of controlled drug release using a heterodisperse polysaccharide matrix." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320433.

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10

Utting, Anita A. "Liquid filled hard gelatin capsules : an investigation of thermosoftened drug/poloxamer solid dispersion formulations in relation to drug release mechanisms." Thesis, University of Sunderland, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327315.

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11

Bode, Corinna. "PLGA implants for ocular drug delivery." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S008.

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Jusqu'à aujourd'hui, le traitement des maladies oculaires postérieures, telles que la dégénérescence maculaire liée à l'âge, la rétinopathie diabétique et l'uvéite, reste difficile. L'œil avec ses différentes barrières oculaires est bien protégé des agressions extérieures. Ces barrières réduisent également la biodisponibilité des médicaments pour le vitré. Après une administration topique, seule une quantité limitée (0,001 - 0,0004 %) permet d'atteindre le vitreux. Ceci est causé par exemple par une dilution des larmes et une faible perméabilité cornéenne du médicament. Après une administratio

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12

Sujja-Areevath, Jomjai. "Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen." Thesis, Robert Gordon University, 1997. http://hdl.handle.net/10059/2347.

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Mini-matrix multiple unit dosage forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as hydroxypropyl methylcellulose (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofen

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13

Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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14

Fahier, Julie. "Polymeric controlled release film coatings." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S025/document.

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Les mini-granules enrobées offrent un grand potentiel pour la libération contrôlée de médicament par voie orale. Cependant, les mécanismes de libération impliqués ne sont pas toujours élucidés et compris. Ainsi, l’impact de certains paramètres de formulation peut être surprenant. Par exemple, il a été démontré dans ce travail :- La libération du propranolol HCl à partir de mini-granules enrobées avec du Kollicoat SR est plus lente si les mini-granules sont composées de noyaux de sucre comparé à des noyaux de cellulose microcristalline (CMC).Généralement, la tendance inverse est observée, car l

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15

Carlson, Paul Albin. "Lipid high-axial-ratio microstructures as pharmaceutical delivery systems : a physical characterization of the mechanisms behind drug release /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/8111.

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16

Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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17

Lee, Wang Wang. "Factors affecting drug release and absorption from a novel oral delayed release drug delivery system." Thesis, Durham University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269886.

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18

Pygall, Samuel R. "Critical processes in drug release from HPMC controlled release matrices." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/14128/.

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This study has investigated the drug release mechanisms from hydroxypropyl methylcellulose (HPMC) hydrophilic matrices. A hypothesis was developed from interpretation of a previous study that drug surface activity has an influence on drug liberation. The validity of the hypothesis was tested by studying the interactions between HPMC and the two non-steroidal anti-inflammatory drugs diclofenac Na and meclofenamate Na, using tensiometry, rheology, NMR, neutron scattering and turbimetry. Meclofenamate Na was found to interact with HPMC, resulting in detectable changes in drug diffusion coefficien

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19

Steiner, Katrin [Verfasser]. "The influence of drug core properties on drug release from extended release reservoir pellets / Katrin Steiner." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025239733/34.

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20

Fitzpatrick, John J. "Drug release from methotrexate polumer conjugates." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259695.

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21

Sheldon, Jonathon. "Light Controlled Drug Activation and Release." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4055.

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Cancer constitutes a terrible burden on modern society. In the United States there are an estimated 1,658,370 new cancer diagnoses resulting in 589,430 deaths in 2015 alone.[1] An estimated 41,170 of these cases will be diagnosed right here in Virginia. With new cancer patients comes the expanding demand for new treatments. As we all know, many modern chemotherapeutics cause adverse reactions to patients. This is because the toxic nature of these therapies often affects normal tissue alongside the tumors that are infesting the body. Therefore, researching novel ways to make chemotherapeutics s

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22

Sinha, Piyush M. "Nanoengineered implantable devices for controlled drug delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1115138930.

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23

Milroy, Georgina Emily. "Degradation and drug release behaviour of polyglycolide." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415273.

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24

Shehab, M. A. "Drug release from liquid filled capsule formulations." Thesis, De Montfort University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373432.

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25

Ambardekar, Rohan. "Controlled drug release from oriented biodegradable polymers." Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14867.

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This research is the first systematic investigation of solid-state orientation as a novel method for controlling drug release from biodegradable polymers. The effect of various degrees of polymer orientation was studied in oriented Poly (L-lactic acid) (PLA) films containing curcumin and theophylline as model drugs. Additionally, direction specific drug release was studied from oriented PLA rods containing paracetamol. The films oriented to 2X uniaxial constant width (UCW) or 2X2Y biaxial draw ratio showed retardation of drug release, when their nematic structure was stabilised by the presence

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26

Sevim, Kevser. "Modelling of drug release from biodegradable polymers." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40864.

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Biodegradable polymers have highly desirable applications in the field of biomedical engineering, such as coronary stents, tissue engineering scaffolds and controlled release formulations. All these applications are primarily rely on the fact that the polymers ultimately disappear after providing a desired function. In this respect, the mechanism of their degradation and erosion in aqueous media has attracted great attention. There are several factors affecting the rate of degradation such as composition, molecular weight, crystallinity and sample size. Experimental investigations showed that

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27

Robinson, Susan. "Poly(α-hydroxyacids) : degradation and drug release". Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624353.

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28

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid

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29

Podaru, George. "Exploring controlled drug release from magneto liposomes." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35544.

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Doctor of Philosophy<br>Department of Chemistry<br>Viktor Chikan<br>This thesis focuses on exploring fast and controlled drug release from several liposomal drug delivery systems including its underlying mechanics. In addition, the construction of a pulsed high-voltage rotating electromagnet is demonstrated based on a nested Helmholtz coil design. Although lots of different drug delivery mechanisms can be used, fast drug delivery is very important to utilize drug molecules that are short-lived under physiological conditions. Techniques that can release model molecules under physiological condi

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30

Chia, Leonard Sze Onn. "Investigating controlled release pulmonary drug delivery systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273209.

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The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved by reducing the number of times drugs need to be administered. In this study, two controlled pulmonary drug delivery systems for drugs of different solubilities were investigated and they were characterised for their viability as effective controlled release pulmonary drug delivery systems, particula

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31

Chaerunisaa, Anis Yohana [Verfasser]. "Release adjustment of drug combinations with different drug solubility / Anis Yohana Chaerunisaa." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1048327388/34.

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32

Pavlakis, Evangelos K. "Novel drug coatings of pharmaceutical suspensions to control drug release of ibuprofen." Thesis, University of Huddersfield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417301.

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33

Wang, Juan. "Characterization of microsphere drug delivery systems during encapsulation and initial drug release /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488202678776876.

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34

Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.

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35

Gilligan, Claire A. "Controlled release polymeric films and pellets." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336028.

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36

Bramer, Tobias. "Prolonged Drug Release from Gels, using Catanionic Mixtures." Doctoral thesis, Uppsala University, Department of Pharmacy, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8303.

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<p>The use of catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining prolonged drug release from gels. It was shown that various commonly used drug compounds are able to form catanionic mixtures together with oppositely charged surfactants. These mixtures exhibited interesting phase behaviour, where, among other structures, vesicles and large worm-like or branched micelles were found. The size of these aggregates makes them a potential means of prolonging the drug release from gels, as only monomer drugs in equilibrium with larger aggregates were readily ab

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37

Veen, Jacoba van der. "A study on programmed drug release from tablets." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1993. http://irs.ub.rug.nl/ppn/293023646.

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38

Paulsson, Mattias. "Controlled Release Gel Formulations for Mucosal Drug Delivery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5173-X/.

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39

Chang, Rong-Kun. "Dual Polymer Microsphere Systems to control drug release /." Ann Arbor : University Microfilms International, 1985. http://www.gbv.de/dms/bs/toc/016417453.pdf.

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40

Fetherston, S. M. "Novel Sustained Release Divices for Vaginal Drug Administration." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527695.

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41

Dennis, Andrew Barriball. "Sustained drug release from semi-solid capsule formations." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328069.

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42

Hyde, Thomas Miles. "Transport in polymers : application to controlled drug release." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363822.

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43

Niknezhad, Sepideh. "STRATEGIC DESIGN OF NANOFIBER CARRIERS FOR DRUG RELEASE." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1513257280368733.

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44

Yeh, Hsi-wei. "Investigation of Polymeric Composites for Controlled Drug Release." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4971.

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The Electrospray (ES) technique is a promising particle generation method for drug delivery due to its capabilities of producing monodisperse PLGA composite particles with unique configurations and high drug encapsulation efficiency. In the dissertation work, the coaxial dual capillary ES was used to generate drug-loaded core-shell PLGA particles to study the effects of particle filling materials, drug loading locations and particle shell thicknesses on the resultant in vitro release behaviors of the hydrophilic and/ or hydrophobic model drugs. Through release profile characterization of drug-

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45

FARINA, MARCO. "Implantable medical devices for drug and cell release." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2709325.

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This work is focused on the research on how to leverage 3D printing technology in the field of cell transplantation. More specifically, the study of an artificial organ for hormone replacement therapies thanks to the close collaboration between the Methodist Hospital Research Institute, Houston, Texas and Politecnico di Torino, Turin, Italy. Cell transplantation offers an attractive therapeutic approach for many endocrine deficiencies. Transplanted endocrine cells or engineered cells encapsulated in the here presented 3D printed device, can act as biological sensors detecting changes in hormo

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46

Sutch, Jonathan C. D. "Optimising Microenvironmental pH and Drug Release from Formulations Containing a Weakly Basic Drug." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489694.

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The release ofpapaverine, a weakly basic drug, is pH dependent. To allow drug release throughout the changing pH milieu ofthe gastrointestinal tract, weak acid modifiers are often added to modify the microenvironmental pH. A technique to measure the microenvironmental pH by confocal microscopy (CLSMpH) has been optimised to allow accurate measurement in coated pellets. A central composite design was used to investigate the effect of formulation factors on drug release and CLSMpHÃ‚Â• Acid modifiers and fillers of varying solubility were also investigated. The solubility and proportion ofthe aci

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47

Ali, Mohamed A. "Preparation, kinetics and mechanism of release of carbofuran lignin-based controlled release formulations." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289103.

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48

Webb, Mark. "Allergen-Induced Chemokine Release from the Bronchial Epithelium: A Novel Lysosomal Release Mechanism." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1399276040.

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49

Ahrenstedt, Lage. "Drug Eluting Hydrogels : Design, Synthesis and Evaluation." Doctoral thesis, University of Cape Town, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-36503.

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Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. With this aim the anti-inflammatory and immunosuppressant drugs rapamycin (Ra) and dexamethasone (Dex) were made water soluble by conjugation with polyethylene glycol (PEG). Ra was attached pendant from the terminal of PEGs while Dex was incorporated into d

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50

Kelm, Mary K. Breese George R. "Investigating the mechanism of ethanol-enhanced GABA release." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2450.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.

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