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Journal articles on the topic 'Mechanism Of Drug Release'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Chowdhury, Nargis A., John Robertson, Ahmed Al-Jumaily та Maximiano V. Ramos. "Fast Release of Sulfosalicylic Acid from Polymer Implants Consisting of Regenerated Cellulose/γ-Ferric Oxide/Polypyrrole". Journal of Applied Chemistry 2014 (22 грудня 2014): 1–7. http://dx.doi.org/10.1155/2014/474268.

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This work presents a comparative study on the rate of drug release from implantable matrices induced by electric and magnetic fields separately for better biomedical applications. The matrices were prepared by coating γ-ferric oxide dispersed regenerated cellulose film by polypyrrole doped with sulfosalicylic acid as an anti-inflammatory drug. The drug release mechanisms were studied under both the electric and the magnetic fields separately in an acetate buffer solution with pH 5.5 and temperature 37°C during a period of 5 hours. The amount of drug released was analysed by UV-Vis spectrophoto

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Kanke, Pralhad K., Pankaj Sawant, Ajit Jadhav, and Md Rageeb Md Usman. "A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 19–22. http://dx.doi.org/10.22270/jddt.v8i5.1852.

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A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of d

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Zhu, Weiwei, Jiajie Long, and Meiwu Shi. "Release Kinetics Model Fitting of Drugs with Different Structures from Viscose Fabric." Materials 16, no. 8 (2023): 3282. http://dx.doi.org/10.3390/ma16083282.

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(1) Background: It is simpler and more environmentally friendly to use supercritical CO2 fluid technology to process skincare viscose fabrics. Therefore, it is significant to study the release properties of drug-loaded viscose fabrics to choose suitable skincare drugs. In this work, the release kinetics model fittings were investigated in order to clarify the release mechanism and provide a theoretical basis for processing skincare viscose fabrics with supercritical CO2 fluid. (2) Methods: Nine kinds of drugs with different substituent groups, different molecular weights, and different substit

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Chudoba, Dorota, Monika Jażdżewska, Katarzyna Łudzik, Sebastian Wołoszczuk, Ewa Juszyńska-Gałązka, and Mikołaj Kościński. "Description of Release Process of Doxorubicin from Modified Carbon Nanotubes." International Journal of Molecular Sciences 22, no. 21 (2021): 12003. http://dx.doi.org/10.3390/ijms222112003.

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and th

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Chakraborty, Santanu, Madhusmruti Khandai, Anuradha Sharma, Ch Patra, V. Patro, and Kalyan Sen. "Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations." Acta Pharmaceutica 59, no. 3 (2009): 313–23. http://dx.doi.org/10.2478/v10007-009-0025-8.

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Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied.

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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Wang, Lei, and Gang Wu. "Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing." Advanced Materials Research 898 (February 2014): 300–303. http://dx.doi.org/10.4028/www.scientific.net/amr.898.300.

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A local drug delivery system constituted by hybrid microsphere/thermosensitive hydrogel was fabricated for Osteoarthritis (OA) therapy in the research. The hydrogel were synthesized by ring-opening copolymerization. Microsphere was fabricated by O/W emulsion and solution evaporation method. The properties of the products were characterized by 1HNMR, FTIR and phase transition diagram. The microsphere/hydrogel was prepared for in vitro drug release research. The results showed microsphere/hydrogel hybrid system can alleviate initial burst release. After 650 hours, only 60 percent of the drugs we

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Nagella, Sivagangi Reddy, Soojeong Choi, Soo-Yong Park, et al. "Depolymerized Chitosan-g-[Poly(MMA-co-HEMA-cl-EGDMA)] Based Nanogels for Controlled Local Release of Bupivacaine." International Journal of Molecular Sciences 24, no. 22 (2023): 16470. http://dx.doi.org/10.3390/ijms242216470.

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This study is designed to formulate and characterize chitosan-based nanogels that provide the controlled delivery of anesthetic drugs, such as bupivacaine (BPV), for effective postoperative pain management over prolonged periods of time. Drug carriers of chitosan/poly (MMA-co-HEMA-cl-EGDMA) (CsPMH) nanogels were prepared by varying the composition of comonomers such as MMA, HEMA, and redox initiator CAN. The nanogels were then characterized using FTIR, TGA, SEM, and TEM. The CsPMH nanogels showed greater encapsulation efficiencies from 43.20–91.77%. Computational studies were also conducted to

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Al-Ali, Maha. "Comparative analyses of Weibull model and conventional kinetics models of drug release of formulated multi-component tablets." Al-Qadisiyah Journal for Engineering Sciences 18, no. 2 (2025): 107–16. https://doi.org/10.30772/qjes.2024.148019.1175.

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The Kinetics study of drug release is an essential requirement to examine the capability of the drug formulation to modulate with the typical drug release profile. In the present work, hence, Weibull model and other traditional drug release models are selected to investigate the release of tablets prepared using different drying techniques in a simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet (MVT), convective drying (CVT), freeze drying (FRT), vacuum drying (VAT), and that without drying process (NDT). This study aims to compare the W

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Kashyap, Kanchan, Mayank Handa, and Rahul Shukla. "Azacitidine Loaded PLGA Nanoparticles and their Dual Release Mechanism." Current Nanomedicine 10, no. 3 (2020): 280–89. http://dx.doi.org/10.2174/2468187310666200225120130.

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Background: Glioblastoma multiforme (GBM) is a belligerent brain tumor constituting about 67% of primary brain tumours. The current therapy for glioblastoma multiforme is surgery, radiations and chemotherapy though the success rate is quite limited. Azacitidine is a hydrophilic anti-cancer agent which acts by demethylation and is used in the treatment of both acute and chronic myelomonocytic leukaemia along with GBM. Objective: Formulation of stable Azacitidine loaded poly-lactide-co-glycolide (PLGA) nanoparticles (NPs) with tailor-made release profiles. Methods: Preparation of Azacitidine loa

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Hurtado, M. González, J. Rieumont Briones, Laura M. Castro González, E. Ortiz Islas, and Inti Zumeta Dube. "Kinetic studies of the release profiles of antiepileptic drug released from a nanostructured TiO2 matrix." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 4 (2016): 4365–73. http://dx.doi.org/10.24297/jac.v12i4.2176.

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In this paper is reported the “in vitro” release kinetic studies of antiepileptic drugs released from an inorganic, titanium oxide (TiO2) porous matrix. In order to determine the drug release mechanism, the experimental values were fitted to different mathematical models: zero-order, firs-order, Higuchi, Hixson-Crowel and Peppas. TiO2 was prepared by the sol-gel method adding valproic acid (VPA) or phenytoine (DHP) during the titanium n-butoxide hydrolysis step. The drug-TiO2 systems were observed by scanning electron microscopy. The “in vitro” release experiments were performed at laboratory

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zur Mühlen, Annette, Cora Schwarz, and Wolfgang Mehnert. "Solid lipid nanoparticles (SLN) for controlled drug delivery – Drug release and release mechanism." European Journal of Pharmaceutics and Biopharmaceutics 45, no. 2 (1998): 149–55. http://dx.doi.org/10.1016/s0939-6411(97)00150-1.

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Agale, Karan A., and Sanket Pandurang Shinde. "A Review on Floating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 204–9. https://doi.org/10.22270/jddt.v15i2.7015.

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Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient struc

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Vuong, Mai Dang Le, Mohamed Haouas, Merve Seray Ural, Didier Desmaële, Charlotte Martineau-Corcos, and Ruxandra Gref. "Degradation of Polymer-Drug Conjugate Nanoparticles Based on Lactic and Itaconic Acid." International Journal of Molecular Sciences 23, no. 22 (2022): 14461. http://dx.doi.org/10.3390/ijms232214461.

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Tuberculosis (TB) is still a significant threat to human health. A promising solution is engineering nanoparticulate drug carriers to deliver anti-TB molecules. Itaconic acid (ITA) potentially has anti-TB activity; however, its incorporation in nanoparticles (NP) is challenging. Here we show an approach for preparing polymer-ITA conjugate NPs and a methodology for investigating the NP degradation and ITA release mechanism. The conjugate was synthesized by the two-directional growing of polylactic acid (PLA) chains, followed by capping their extremities with ITA. The poly(lactate)-itaconate PLA

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Vakil, Anand Utpal, Maryam Ramezani, and Mary Beth B. Monroe. "Magnetically Actuated Shape Memory Polymers for On-Demand Drug Delivery." Materials 15, no. 20 (2022): 7279. http://dx.doi.org/10.3390/ma15207279.

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Repeated use of intravenous infusions to deliver drugs can cause nerve damage, pain, and infection. There is an unmet need for a drug delivery method that administers drugs on demand for prolonged use. Here, we developed magnetically responsive shape memory polymers (SMPs) to enhance control over drug release. Iron oxide magnetic nanoparticles (mnps) were synthesized and incorporated into previously developed SMPs to enable magnetically induced shape memory effects that can be activated remotely via the application of an alternating magnetic field. These materials were tested for their shape m

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Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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Jian, Hong Lei, Li Wei Zhu, Wei Ming Zhang, Xiang Qi, and Jian Xin Jiang. "Evaluation of Galactomannan from Gleditsia Sinensis Lam. as Sustained Release Material in Colonic Drug Delivery." Advanced Materials Research 146-147 (October 2010): 589–98. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.589.

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The galactomannan from endosperm of G. sinensis seeds was used as sustained release material in the matrix tablets prepared at different concentration of 5, 10 and 15 % corresponding to formulations of G5, G10 and G15, for the release of theophylline. The drug release behaviors of the systems were investigated, including the swelling and morphological studies and texture analysis. The dissolution tests were conducted in 0.1 M hydrochloric acid and pH 6.8 phosphate buffered saline. The results of release studies demonstrated that G10 with 10 % galactomannan concentration showed a better control

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Mangilal, Teelavath, and Shiva Kumar Y. "Formulation and In Vitro Evaluation of Bilayered Matrix Tablets of Pioglitazone for Immediate Release and Glimepiride for Extended Release." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 6 (2018): 4348–54. http://dx.doi.org/10.37285/ijpsn.2018.11.6.8.

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Bi-layer tablets are novel drug delivery systems where a combination of two or more drugs in a single unit having different release profiles which improves patient compliance and prolongs the drug action. The study was performed to design bilayer matrix tablets of pioglitazone for immediate release and glimepiride for extended release delivery system. Bilayered matrix tablets composed of two layers, one is immediate release and a second layer is extended release layers. The immediate release layer comprised sodium starch glycolate, and croscarmellose sodium as super disintegrates and extended

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Shahid, Hafsa, Ayesha Ahmed, Ammarah Ashraf, Nida Rashid, and Mubashir Rehman. "An Insight About the Drug Release Mechanisms from Different Dosage Forms." Global Drug Design & Development Review I, no. I (2016): 1–8. http://dx.doi.org/10.31703/gdddr.2016(i-i).01.

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A process in which drug comes out from drug product and exposed to ADME and finally become accessible for pharmacological activity is known as drug release and mechanism involves the study of its rate and factors influencing its rate. Factors influencing the rate of drug release are drug related, polymer related and formulation variables. Drug delivery systems are discriminated on the basis of way drug is delivered, which are immediate release and modified release. Parenteral dosage forms are the most prominent among different dosage forms. The mechanisms involved in drug release are diffusion

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Jiabi, Ouyang, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, and Li Sha. "Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating." Journal of Pharmaceutical and Biomedical Sciences 10, no. 04 (2020): 81–90. https://doi.org/10.5281/zenodo.3903240.

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<em><strong>Core tip:</strong></em> The development of pharmacology in the decade revealed the biological rhythm of the occurrence and development of certain diseases, usually the circadian rhythm. Therefore, chronopharmacological drug delivery is of great significance in the prevention and treatment of diseases having onset rhythm inconvenient to take drug. An easy-to-prepared, time-controlled explosive metoprolol tartaric pulsatile tablet was developed in order to provide patients with timed therapy of effective blood drug concentration at the optimal time. The formulation and process were o

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Song, Wanpeng. "The mechanism and design strategy of metal-organic frameworks in drug delivery." Applied and Computational Engineering 7, no. 1 (2023): 188–95. http://dx.doi.org/10.54254/2755-2721/7/20230435.

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In the field of drug transport, the traditional drugs used for drug delivery are organic, inorganic, and complex. The organic polymer system and liposome system can have good biocompatibility, but the porosity of the polymer cannot be determined, and the medicine cannot be given a controlled release. In contrast, inorganic materials such as microporous zeolite and mesoporous silicon can achieve controlled drug release due to their definite relative porosity, but their drug-loading capacity and poor biocompatibility cannot be widely used for drug delivery. The materials of the new MOFs can synt

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D'Souza, Ajit Joseph M., Richard L. Schowen, and Elizabeth M. Topp. "Polyvinylpyrrolidone–drug conjugate: synthesis and release mechanism." Journal of Controlled Release 94, no. 1 (2004): 91–100. http://dx.doi.org/10.1016/j.jconrel.2003.09.014.

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Ch, Ramesh, Ramu B, and Rajkamal B. "Formulation of Colon Specific Didanosine Enteric Coated Matrix Tablets Using pH Sensitive Polymer." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 207–20. https://doi.org/10.5281/zenodo.13754051.

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The objective of present study is to develop the colon specific Didanosine enteric coated matrix tablets using release retardant polymer and pH sensitive polymer Eudragit L100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Didanosine from coated tablets was investigated. The results showed that less than 10% drug was released in 0.1 N HCl within 2 hr, and about 90% of the drug was released in the pH 7.4 phosph

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Li, Conghui, Xiaolu Han, Xiaoxuan Hong, et al. "Study on the Complexation and Release Mechanism of Methylphenidate Hydrochloride Ion Exchange Resin Complex." Polymers 13, no. 24 (2021): 4394. http://dx.doi.org/10.3390/polym13244394.

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Since the advent of ion exchange resin, it has been widely used in many fields, including drug delivery systems. The drug binds to the resin through an exchange reaction to form a drug–resin complex, which can gradually release drugs through the exchange of physiological ions in the gastrointestinal tract, to realize functions such as taste masking and regulating release. In this study, the complexes of methylphenidate hydrochloride and Amberlite IRP69 were prepared and evaluated to explore the mechanism of complexation, influencing factors and release mechanism at a molecular level. Firstly,

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Shende, M. A., and Yogesh P Khedkar. "Development and Evaluation of Gastrobioadhesive Glimepiride Sustained Release Matrix Tablet Using Aegle Marmelos Polysaccharide." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 1 (2020): 5297–306. http://dx.doi.org/10.37285/ijpsn.2021.14.1.5.

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The purpose of present study was to formulate and evaluate glimepiride gastrobioadhesive drug delivery using Aegle Marmelos polysaccharide and synthetic polymer for prolongation of gastric residence time and reduce the dosing frequency. Glimepiride matrices were prepared by direct compression method and evaluated with an aim of presenting glimepiride as sustained release for improving the patient’s compliance. A central composite design (CCD) was employed as Aegle Marmelos polysaccharide (X1) and HPMC K4M (X2) independent variables to optimize the glimepiride in terms of sustained release and

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Khan, Kamran Ahmad, Gul Majid Khan, Muhammad Muzammal, et al. "Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents." Molecules 27, no. 3 (2022): 864. http://dx.doi.org/10.3390/molecules27030864.

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Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method

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Gou, Guo Jing, Li E. Dong, Feng Juan Bao, et al. "A Review on Research of the Sustained Release Drug Delivery System Based on Magnesium Aluminate Layered Double Hydroxide." Applied Mechanics and Materials 320 (May 2013): 495–504. http://dx.doi.org/10.4028/www.scientific.net/amm.320.495.

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This paper reviewed our research progress in respects of th intercalation law of acetylsalicylic acid (ASP) with magnesium aluminate layered double hydroxide (LDH), the drug release mechanism and the tablet preparation effect of LDH-ASP system. We also discussed the propositions about the composite assembly rules, slow-release mechanism, and dosage form processing of the layered double hydroxide drug delivery system. Intercalation way and drug structure should be taken into consideration in assembly LDH-drugs system. The characteristic parameter of the composite LDH-drug reflected finely their

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Wani, Taha Umair, and Nisar Ahmad Khan. "Formulation of Carbopol Capsules for Sustained Release of Losartan Potassium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 92–97. http://dx.doi.org/10.22270/jddt.v9i2-s.2468.

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Sustained release formulations have been extensively studied for their benefits in improving various physicochemical and pharmacokinetic properties of large number of drugs. The aim of this study was to develop and evaluate sustained release capsules of losartan potassium in order to provide drug release over a long period of time. This allows the drug much time for absorption in gastrointestinal tract (GIT) and hence may increase the bioavailability of the drug. Carbopol 971 P was used as rate controlling polymer for the preparation of capsules. The capsules were evaluated for matrix integrit

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Adepu, Shivakalyani, Hongrong Luo, and Seeram Ramakrishna. "Heparin-Tagged PLA-PEG Copolymer-Encapsulated Biochanin A-Loaded (Mg/Al) LDH Nanoparticles Recommended for Non-Thrombogenic and Anti-Proliferative Stent Coating." International Journal of Molecular Sciences 22, no. 11 (2021): 5433. http://dx.doi.org/10.3390/ijms22115433.

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Drug-eluting stents have been widely implanted to prevent neointimal hyperplasia associated with bare metal stents. Conventional polymers and anti-proliferative drugs suffer from stent thrombosis due to the non-selective nature of the drugs and hypersensitivity to polymer degradation products. Alternatively, various herbal anti-proliferative agents are sought, of which biochanin A (an isoflavone phytoestrogen) was known to have anti-proliferative and vasculoprotective action. PLA-PEG diblock copolymer was tagged with heparin, whose degradation releases heparin locally and prevents thrombosis.

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Zuleger, Susanne, and Bernhard C. Lippold. "Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism." International Journal of Pharmaceutics 217, no. 1-2 (2001): 139–52. http://dx.doi.org/10.1016/s0378-5173(01)00596-8.

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Arpitha, G., S.M. Preethi, Wodeyar Poojitha, D.S. Kalyani, P. Tejas, and K.M. Harish. "Nanosponges Overview on Novel Drug Delivery Formulation." International Journal of Current Science Research and Review 07, no. 08 (2024): 6190–97. https://doi.org/10.5281/zenodo.13269457.

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Abstract : Targeting the drug to a particular site to reduce the drug toxicity requires a special drug delivery system. Nanosponges are tiny particals with porous cavities to facilitate drug substances. Nanosponges efficiently transport both hydrophilic and lipophilic drug substances the present manuscript focus method of preparation, mechanism of drug release, evaluation and application of nanosponges.

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Munj, Hrishikesh R., John J. Lannutti, and David L. Tomasko. "Understanding drug release from PCL/gelatin electrospun blends." Journal of Biomaterials Applications 31, no. 6 (2016): 933–49. http://dx.doi.org/10.1177/0885328216673555.

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Electrospinning is one of the efficient processes to fabricate polymeric fibrous scaffolds for several biomedical applications. Several studies have published to demonstrate drug release from electrospun scaffolds. Blends of natural and synthetic electrospun fibers provide excellent platform to combine mechanical and bioactive properties. Drug release from polymer blends is a complex process. Drug release from polymer can be dominated by one or more of following mechanisms: polymer erosion, relaxation, and degradation. In this study, electrospun polycaprolactone (PCL)–gelatin blends are invest

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Sunil, Songa Ambedkar, Meka Venkata Srikanth, Nali Sreenivasa Rao, Sakamuri Balaji, and Kolapalli Venkata Ramana Murthy. "Design and evaluation of lornoxicam bilayered tablets for biphasic release." Brazilian Journal of Pharmaceutical Sciences 48, no. 4 (2012): 609–19. http://dx.doi.org/10.1590/s1984-82502012000400004.

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The objective of the present investigation was to develop bilayered tablets of lornoxicam to achieve biphasic release pattern. A bilayered tablet, consisting of an immediate and controlled release layer, was prepared by direct compression technique. The controlled release effect was achieved by using various hydrophilic natural, semi synthetic and synthetic controlled release polymers such as xanthan gum, hydroxypropyl methylcellulose (HPMC) and polyethylene oxide (PEO) to modulate the release of the drug. The in vitro drug release profiles showed the biphasic release behavior in which the imm

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Wang, Y. J., F. Ravenelle, and X. X. Zhu. "NMR imaging study of cross-linked high-amylose starch tablets — The effect of drug loading." Canadian Journal of Chemistry 88, no. 3 (2010): 202–7. http://dx.doi.org/10.1139/v09-170.

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NMR imaging techniques were used to study the effect of drug loading in cross-linked high-amylose starch tablets. The tablets contained acetaminophen with loading levels from 10 to 40 wt%. The absolute amount of the drug released increased with a larger amount of drug loading, but the percentages of drug released had only minor differences for the different tablets, probably due to the rapid formation of a gel layer for all the tablets, which slowed down drug release significantly. The release of drugs from the tablets in all cases is dominated by a diffusion mechanism before the disappearance

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Rao, Tadikonda Rama, Billa Sravani, and Ratnapuram Aarthi. "Nanocarriers in Drug Delivery Systems: An Overview." Journal of Advanced Scientific Research 16, no. 03 (2025): 8–14. https://doi.org/10.55218/jasr.2025160302.

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Nanocarriers have emerged as a transformative technology in drug delivery systems (DDS), offering significant advancements over traditional methods. This review delves into the various types of nanocarriers, including liposomes, polymeric nanoparticles, micelles, dendrimers, and solid lipid nanoparticles, highlighting their unique properties and advantages in targeted drug delivery. Liposomes have demonstrated extraordinary effectiveness in clinical applications due to their biocompatibility. Conversely, polymeric nanoparticles offer improved stability and regulated drug release, which makes t

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Mutagond, Chetankumar, Vinod M R, Vijapure V M, et al. "Formulation and Evaluation of Spray Dried Microspheres of Controlled Release Ramipril." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 2 (2018): 4059–66. http://dx.doi.org/10.37285/ijpsn.2018.11.2.8.

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The present study sought to develop and evaluate spray-dried microspheres of chitosan and xanthan gum for controlled release of ramipril, a widely used antihypertensive drug. The prepared microspheres were characterized by particle size analysis, scanning electron microscopic studies, differential scanning calorimetric analysis, Fourier transform infrared spectroscopy analysis, X-ray diffraction studies, drug entrapment efficiency, and in-vitro drug release study. The prepared microspheres were spherical in shape and freely flowing. The size of the microspheres was in the range of 25.7 to 47.4

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Himiniuc, Loredana, Maricel Agop, Vlad Ghizdovat, et al. "A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives." Materiale Plastice 57, no. 4 (2021): 155–65. http://dx.doi.org/10.37358/mp.20.4.5415.

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Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient s comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a c

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Chongcherdsak, Noppadol, Direk Aekthammarat, Teerayuth Prathumchat, Chutima Limmatvapirat, and Sontaya Limmatvapirat. "Fabrication of Shellac-Zein Based Matrix Tablet as a Carrier for Controlling of Drug Release." Advanced Materials Research 1060 (December 2014): 50–53. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.50.

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The aim of research was to fabricate shellac-zein composite polymer-based matrix tablets by using theophylline as a model drug. The tablets were prepared by direct compression process. The initial weight and hardness of tablets were controlled within the range of 300±5 mg and 60±10 N, respectively. The tablets were annealed at 80 °C for 24 h and kept in the ambient temperature before evaluation. Drug release profile and kinetics of drug release in 0.1 N HCl and buffer pH 6.8 were investigated. The result showed that the annealing process and shellac:zein ratio, affected drug release characteri

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Yuan, Chunping, Huimin Hou, Shuyun Ou, Shujing Zhao, Yongjian Gao, and Qing Liu. "New Technology of Thermoplastic Coating for Osmotic Pump Tablets: Study on in vitro Drug Release." Pharmaceutical Fronts 01, no. 01 (2019): e1-e10. http://dx.doi.org/10.1055/s-0039-1693125.

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Aim The in vitro drug release profiles of metformin hydrochloride thermoplastic coated tablets and nifedipine thermoplastic coated tablets were studied. Methods By measuring the in vitro release profiles of the thermoplastic coated tablets of model drugs, the effects of membrane thickness, polyethylene glycol-1,500 (PEG1500) content, number of orifice, stirring speed, and release medium on the drug release were investigated, and the rule and mechanism of drug release were also analyzed by comparing with the osmotic pump tablets (OPTs). Results Thermoplastic coated tablets with single- or doubl

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Reddy S, Giridhar. "Kinetic Studies for the Release of Hydroxychloroquine Sulphate Drug (HCQ) In-vitro in Simulated Gastric and Intestinal Medium from Sodium Alginate and Lignosulphonic Acid Blends." Trends in Sciences 20, no. 5 (2023): 5318. http://dx.doi.org/10.48048/tis.2023.5318.

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Biodegradable polymeric blends are used to study the controlled release of Hydroxychloroquine sulphate (HCQ) as the model drug used extensively in COVID-19 treatments. HCQ drug is loaded in sodium alginate (NaAlg) and lignosulphonic acid (NaLS) blends as matrix are crosslinked using calcium chloride solution. Its release is evaluated in different pH mediums of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The HCQ release data obtained during experimentation is used to study kinetics using different models to investigate polymeric relaxation's drug diffusion and mechanism

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Uzunalli, Gozde, and Mustafa O. Guler. "Peptide gels for controlled release of proteins." Therapeutic Delivery 11, no. 3 (2020): 193–211. http://dx.doi.org/10.4155/tde-2020-0011.

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Treatment strategies in clinics have been shifting from small molecules to protein drugs due to the promising results of a highly specific mechanism of action and reduced toxicity. Despite their prominent roles in disease treatment, delivery of the protein therapeutics is challenging due to chemical instability, immunogenicity and biological barriers. Peptide hydrogels with spatiotemporally tunable properties have shown an outstanding potential to deliver complex protein therapeutics, maintain drug efficacy and stability over time, mimicking the extracellular matrix, and responding to external

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Field, Rachel D., Margaret A. Jakus, Xiaoyu Chen, et al. "Ultrasound-responsive hydrogel microcapsules for on-demand drug release." Journal of the Acoustical Society of America 154, no. 4_supplement (2023): A279. http://dx.doi.org/10.1121/10.0023522.

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Hydrogel-based implantable systems offer viable solutions for localized drug delivery but often lack the ability to easily achieve on-demand actuation or real-time tuning of release kinetics in response to physiological changes. Here, we present a hydrogel microcapsules produced using two-phase microfluidics that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules consist of an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that b

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Jackson, Nicolás, Andrea C. Ortiz, Alejandro Jerez, Javier Morales, and Francisco Arriagada. "Kinetics and Mechanism of Camptothecin Release from Transferrin-Gated Mesoporous Silica Nanoparticles through a pH-Responsive Surface Linker." Pharmaceutics 15, no. 6 (2023): 1590. http://dx.doi.org/10.3390/pharmaceutics15061590.

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Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on the anticancer effect; therefore, the design of the nanocarrier and the mechanisms that govern drug release play a crucial role in optimizing efficacy. Here, we synthesized and characterized mesoporous silica nanoparticles with transferrin conjugated on their surf

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Viswanath, V., U. Chandrasekhar, B. Narasimha Rao, and K. Gnana Prakash. "Development and evaluation of sustained release matrix tablets of losartan potassium." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 1, no. 04 (2016): 127–32. http://dx.doi.org/10.21477/ijapsr.v3i1.4858.

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The objective of the present study was to develop a sustained release matrix tablets of Losartan potassium, an anti hypertensive drug. The sustained release tablets were prepared by wet granulation and formulated using different drug and polymer ratios. Hydrophilic natural polymers like xanthan Gum (XG), guar gum and cellulose were used. Compatibility of the drug with various excipients was studied. The compressed tablets were evaluated and showed compliance with Pharmacopoeial limits. Formulation was optimized (F2) on the basis of acceptable tablet properties and in vitro drug release. The re

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Salfi, Roshan, Fatima Shireen, and Makula Ajitha. "Optimization of Repaglinide Osmotic Drug Delivery System Using Two Different Techniques." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 01 (2022): 29–36. http://dx.doi.org/10.25004/ijpsdr.2022.140104.

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The current study aimed to formulate an elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) based drug delivery system for controlled release of an anti-diabetic agent, repaglinide is expected to provide sustained release. EOP and PPOP method prepared repaglinide tablets by wet granulation technique. EOP designed 15 formulations F1-F15 and 14 formulations were done by PPOP method. All the formulations were evaluated for various physicochemical parameters and in-vitro dissolution studies. The release data was fitted into mathematical kinetic modeling studies to check the release mec

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Skalická, Barbora, Kevin Matzick, Alena Komersová, Roman Svoboda, Martin Bartoš, and Luděk Hromádko. "3D-Printed Coating of Extended-Release Matrix Tablets: Effective Tool for Prevention of Alcohol-Induced Dose Dumping Effect." Pharmaceutics 13, no. 12 (2021): 2123. http://dx.doi.org/10.3390/pharmaceutics13122123.

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Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of the release mechanism in the presence of alcohol due to the possible occurrence of the dose dumping effect. The effect of 3D printing (3DP) coating on the drug release mechanism and the drug release rate was studied as a possible tool for the prevention of the alcohol-induced dose dumping effect. Th

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Jung, Hyun, Hyun-Mi Kim, Young Bin Choy, Seong-Ju Hwang, and Jin-Ho Choy. "Itraconazole–Laponite: Kinetics and mechanism of drug release." Applied Clay Science 40, no. 1-4 (2008): 99–107. http://dx.doi.org/10.1016/j.clay.2007.09.002.

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Park, Kinam. "Probing the mechanism of drug release from liposomes." Journal of Controlled Release 294 (January 2019): 390. http://dx.doi.org/10.1016/j.jconrel.2019.01.003.

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Ji, Yuanhui, Anna Katharina Lesniak, Anke Prudic, Raphael Paus, and Gabriele Sadowski. "Drug Release Kinetics and Mechanism from PLGA Formulations." AIChE Journal 62, no. 11 (2016): 4055–65. http://dx.doi.org/10.1002/aic.15282.

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