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Journal articles on the topic 'Mechanism of extended-release tablet'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

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A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

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2

Chaiya, P., and T. Phaechamud. "Theophylline extended-release monolithic matrix comprising natural rubber latex as binder." IOP Conference Series: Materials Science and Engineering 1234, no. 1 (2022): 012001. http://dx.doi.org/10.1088/1757-899x/1234/1/012001.

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Abstract A major component of polymer in natural rubber latex (NRL) obtained from Hevea brasiliensis consists of poly-cis-1,4-isoprene. Poly-cis-1,4-isoprene exhibited interesting physical properties suitable for possible use as a binder in pharmaceutical solid dosage forms such as monolithic matrix tablet. The aim of this study was to study the feasibility of using NRL as the binder in theophylline anhydrous (THE)-incorporated monolithic matrix tablet in comparison with polyvinyl pyrrolidone K-30 (PVP-30). Physical properties of granules and tablets fabricated with wet granulation and tableti

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3

Likhariya, Manoj, Dipali Trivedi, Juhi Bhadoria, and Amit Modi. "Formulation and Evaluation of Cefaclor Extended-Release Tablet." Journal of Drug Delivery and Therapeutics 11, no. 6-S (2021): 33–36. http://dx.doi.org/10.22270/jddt.v11i6-s.5193.

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Over past 30 years as the expanse and complication involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of extended or controlled release drug delivery systems. In the present research work an attempt has been made to optimize, formulate and characterize extended-release tablet of Cefaclor. The preformulation studies were performed for the drug (e.g., physico-chemical properties, melting point, solubility etc.). The drug had shown the results under

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4

Sugandini, G., and M. Sunitha Reddy. "An Overview on Classification, Mechanism of Extended Release Drug Delivery of Oral Formulations." Journal of Drug Discovery and Therapeutics 11, no. 3 (2023): 06–17. http://dx.doi.org/10.32553/jddt.v11i3.472.

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ER is defined as a dosage form designed to release the medication in a controlled manner during an extended period of time, at a predetermined rate, duration, and location following administration. At steady state, the rate of absorption is approximately equivalent to the rate of elimination due to metabolism and excretion. ER (extended release) tablets shows the better patient compliance through reduction of frequency of dose administration and also maintain the therapeutic concentration over a long period of time it help to reduce the side effect of the drug and shows better effect. The ER t

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Gunda, Raghavendra K., Naga Suresh K. Jujjuru, Vijayalakshmi A., Prathap M., and Koteswararao G. S. N. "STATISTICAL OPTIMIZATION AND ASSESSMENT OF DIVALPROEX SODIUM EXTENDED RELEASE TABLET." INDIAN DRUGS 60, no. 08 (2023): 31–37. http://dx.doi.org/10.53879/id.60.08.13485.

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The purpose of the current experimental research was to optimize the quantities of macromolecules such as Eudragit L/100-55 and HPMC-K-100M for the development of extended release tablets of divalproex sodium, an anti-convulsant or epileptic agent used in the effective management of bipolar disorders, mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of Eudragit L/100-55 and HPMC-K-100M in variable compositions and variable amounts as per 32 factorial design technique. Tablets were prepared by direct compression technique. Quantities of

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K., Ramanji Reddy*1 Dr. S. Jaya 2. V. Sandhya Rani 2. Dr. Chandaka Madhu1. "DEVELOPMENT AND EVALUATION OF TAPENTADOL HYDROCHLORIDE EXTENDED RELEASE TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 922–37. https://doi.org/10.5281/zenodo.1181846.

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Extended release tablets of Tapentadol hydrochloride were prepared by wet granulation method using microcrystalline cellulose PH101, sodium carboxy methyl cellulose, polyvinyl pyrrolidine (K-90), methocel K 200M and plasdone. The drug and excipients compatibility was studied by FT-IR which showed no physico-chemical interaction. The polymer used Hydroxy propyl ethyl cellulose was granular blend. Also it was concluded that it improves the drug release at 12th hour. The kinetic treatment of the drug release data of the prepared formulations followed zero order drug release the prepared formulati

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Lakshmi S., Satya, Jyothsna P, Srinivasa Rao Y., and Naga Mallikarjun P. "ROSUVASTATIN CALCIUM NANOSPONGES IN THE FORMULATION OF EXTENDED RELEASE TABLETS." INDIAN DRUGS 58, no. 10 (2021): 25–33. http://dx.doi.org/10.53879/id.58.10.12299.

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Cyclodextrin has been recognized as a linker molecule that can link with the various drug substances to produce a nano-porous structure called nanosponges (NS) and increase the dissolution rate of poorly soluble drug substances. This work aimed to load rosuvastatin calcium (RSC) with solubility enhancer’s β-cyclodextrin (β-CD) or polyvinyl alcohol (PVA). β-CD based RSC-NS were fabricated by the emulsion solvent diffusion technique; with solubilizer dichloromethane and different ratios of ethyl cellulose as a co-polymer. Characterization of the prepared nanosponges was done by various testing p

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8

Das, Urmi, and Mohammad Salim Hossain. "Effects of release modifier on Carvedilol release from Kollidon SR based matrix." International Current Pharmaceutical Journal 1, no. 8 (2012): 186. http://dx.doi.org/10.3329/icpj.v1i8.11095.

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<p>Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of

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Journal, Devanshi, Dibya Kumari, and Umesh Kumar Jain. "Formulation and Evaluation of Gastroretentive Bilayer Tablets." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 107–12. http://dx.doi.org/10.22270/jddt.v14i9.6784.

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Gastroretentive bilayer tablets were designed to prolong the gastric residence time after oral administration and to achieve immediate release of lansoprazole and controlled release floating layer of clarithromycin to treat gastric ulcers. Instant release layer has a combination of super disintegrating agents. A combination of effervescent mechanism is used. HPMC K5 was used as swelling polymer and citric acid, sodium bicarbonate as gas generating agent to reduce the floating lag time. Bilayer floating tablets were prepared with varying proportions of instant layer and sustained release floati

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10

Shani, Jashovam, Shimon Benita, Muhamed Abdulrazik, and Aharon Yerushalmi. "Efficacy of Sustained-Release Radioprotective Drugs in vivo." Zeitschrift für Naturforschung C 42, no. 11-12 (1987): 1323–27. http://dx.doi.org/10.1515/znc-1987-11-1229.

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In previous publications from this laboratory we suggested the use of radioprotective drugs in a sustained-release form as a practical way to cope with their high toxicity and quick metabolism and excretion. Cysteine and cysteamine, well-established radioprotectants, were used as model drugs and compressed at various concentrations (0-65%) into an insoluble tablet matrix, composed of ethylcellulose and stearic acid at various ratios and compression pressures. We demonstrated in vitro that when the release rate of the radioprotectants was measured under nitrogen, the kinetic data conformed with

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S. Chandra, Amritha. J, and N. Senthil Kumar. "Formulation and evaluation of floating tablets containing for selected antibiotic." IJPAR JOURNAL 13, no. 4 (2024): 834–44. https://doi.org/10.61096/ijpar.v13.iss4.2024.834-844.

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Floating tablets were prepared using direct compression with varying ratios of Karaya gum, Carbopol, and Xanthan gum. The preformulation studies included drug description, solubility, pH, and compatibility testing through infrared spectroscopy. Post-compression evaluation parameters included weight variation, thickness, hardness, friability, drug content, tablet density, floating test, swelling index, and in vitro dissolution studies. Results indicated that the formulated tablets met all standard physicochemical parameters. Floating tests demonstrated that the tablets remained buoyant for over

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M., Durgarao*, Lakshmi Kavya G., Bhanu Mallika A.V., Srivinay G., Ravi P., and Lahari V. "FORMULATION AND EVALUATION OF PROLONGED RELEASE GEMFIBROZIL TABLETS." World Journal of Pharmaceutical Science and Research 3, no. 3 (2024): 325–33. https://doi.org/10.5281/zenodo.12732807.

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The development of prolonged-release formulations of pharmaceuticals is essential for enhancing therapeutic efficacy and patient compliance. This study focuses on the formulation and evaluation of prolonged-release Gemfibrozil tablets, a lipid-regulating agent used in the management of hyperlipidemia. The primary objective was to design a tablet that ensures sustained release of Gemfibrozil, thereby maintaining a consistent plasma concentration over an extended period. The formulation process involved the selection of appropriate polymers and excipients to achieve the desired release profile.

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13

Jiabi, Ouyang, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, and Li Sha. "Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating." Journal of Pharmaceutical and Biomedical Sciences 10, no. 04 (2020): 81–90. https://doi.org/10.5281/zenodo.3903240.

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<em><strong>Core tip:</strong></em> The development of pharmacology in the decade revealed the biological rhythm of the occurrence and development of certain diseases, usually the circadian rhythm. Therefore, chronopharmacological drug delivery is of great significance in the prevention and treatment of diseases having onset rhythm inconvenient to take drug. An easy-to-prepared, time-controlled explosive metoprolol tartaric pulsatile tablet was developed in order to provide patients with timed therapy of effective blood drug concentration at the optimal time. The formulation and process were o

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Riaz, Muhammad, Liaqat Ali, Saba Javed, Syed Aatif Hussain, Hassan Haider Shah, and Khaleeq Anwer. "Development and in-vitro characterization of tiropramide tablets having immediate- and extended release layers." Journal of Contemporary Pharmacy 3, no. 1 (2019): 12–19. http://dx.doi.org/10.56770/jcp2019313.

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Purpose: The objective of this study was to explore the feasibility of developing of Tiropramide, bilayer tabletusing an immediate- and extended-release formulation. Method: After rheological performance of drug-excipientsmixture, Tiropramide HCl bilayer tablets were prepared by wet granulation method. FTIR analysis was performed toelucidate the compatibility behavior of drug and excipients. Effect of these varying concentrations of EthylCellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) were observed on the sustained release pattern of thematrices. Dissolution was performed by using 0.

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Viswanad, Vidya. "FORMULATION AND EVALUATION OF NOVEL CHROMENE DERIVATIVE AS AN ANTI INFLAMMATORY AGENT USED FOR IBD." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 319. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15696.

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Objective: To formulate and evaluate an extended-release (ER) tablet of a new molecule, 2-amino-4-(4-bromophenyl)-7-hydroxy-4H-chromene-3- carbonitrile using a combination of two polymers (hydroxypropyl methyl cellulose [HPMC] K100 and HPMC phthalate) which control the rate and degree of the drug release through 12 hrs period and protect the drug release from acidic pH.Methods: Five batches of tablets (4HC1, 4HC2, 4HC3, 4HC4, 4HC5) were produced by direct compression method. Morphological evaluation of the powder blend was carried out by differential scanning calorimetry and Powered X-ray diff

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16

Sultana, Sharifa, Shimul Halder, AK Lutful Kabir, and Abu Shara Shamsur Rouf. "Effect of solubility enhancers on the release of Carbamazepine from Hydrophilic Polymer based matrix tablet." Dhaka University Journal of Pharmaceutical Sciences 13, no. 2 (2015): 167–73. http://dx.doi.org/10.3329/dujps.v13i2.21894.

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In the present study, an attempt has been taken to evaluate the effect of sodium lauryl sulphate (SLS) and glyceryl mono stearate (GMS) as solubility enhancers on the release profile of a poorly soluble drug, carbamazepine. Matrix tablets of carbamazepine were prepared by wet granulation technique using hydrophilic polymers (10% of Methocel K15 MCR and 10% of Methocel K100LV CR) as release controlling agents. Varying amounts of SLS and GMS were used in six different formulations to observe the impact on the release rate and mechanism of drug release. The dissolution study of carbamazepine from

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17

Das, Urmi, and Mohammad Salim Hossain. "Effects of release modifier on Carvedilol release from Kollidon SR based matrix." International Current Pharmaceutical Journal 1, no. 8 (2012): 186–92. http://dx.doi.org/10.3329/icpj.v1i8.11248.

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Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcry

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18

Khan, Kamran Ahmad, Gul Majid Khan, Muhammad Muzammal, et al. "Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents." Molecules 27, no. 3 (2022): 864. http://dx.doi.org/10.3390/molecules27030864.

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Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method

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19

Agale, Karan A., and Sanket Pandurang Shinde. "A Review on Floating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 204–9. https://doi.org/10.22270/jddt.v15i2.7015.

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Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient struc

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Singh, Sudarshan, Shankar Bhavesh, Sanjaykumar Nayak, and Sunil Bothara. "Formulation and Evaluation of Levetiracetam Extended Release Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 1 (2013): 1958–65. http://dx.doi.org/10.37285/ijpsn.2013.6.1.6.

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Extended release formulation of levetiracetam is approved by the food and drug administration as an add-on to other antiepileptic drugs for adults with partial onset seizures. The main objective of present study was to developed and evaluate matrix tablet of levetiracetam by using various grade of hydroxypropylmethylcellulose (HPMC) polymer. Various trials were taken by using HPMC K4M, K15M, and K100M. Different parameters like Physical properties, FTIR, DSC, in vitro drug release profile and swelling index were determined. In vitro drug release was performed in phosphate buffer pH 6.8. The in

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Panchal, Anil B., and Supriya V. Mudgulkar. "Formulation and Evaluation of Sustained release tablet of Trazodone hydrochloride by using Synthetic Polymer RS100 and RL 100." Journal of Drug Delivery and Therapeutics 15, no. 6 (2025): 61–70. https://doi.org/10.22270/jddt.v15i6.7169.

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Sustained release tablet was prepared by wet granulation method using synthetic polymer RS 100 and RL 100. The prepared tablet was also evaluated for their diameter, thickness, drug content, Hardness, friability, weight variation. The thickness and diameter of tablet ranges from 5.43 ±0.288 to 5.76 ±0.05 and 09.68±0.577 to 10.04 ±0.04 respectively. Drug content was studied and its ranges from 92.03 to 98.60 %. Hardness was studied its ranges 5.5 to 6.5 kg/cm2, Friability ranges 0.71 to 0.95%, Weight variation ranges between 434±1.49 to 460±1.23. FTIR and DSC analysis does not show any interact

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Anjali, Bagmar, and Tikariya Komal. "SUSTAINED RELEASE MATRIX DRUG DELIVERY SYSTEM: AN OVERVIEW." International Journal of Pharmaceutical Sciences and Medicine 6, no. 9 (2021): 79–87. http://dx.doi.org/10.47760/ijpsm.2021.v06i09.006.

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Oral delivery of drugs is the most preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc. Sustained release constitutes are the dosage form that provides medication over an extended time or denotes that the system is able to provide some actual therapeutic control whether this is of a temporal nature, spatial nature or both. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance del

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P, Pavazhaviji, and Rajalakshmi A. N. "FIXED-DOSE COMBINATION DRUGS AS TABLET IN TABLET: A REVIEW." International journal of multidisciplinary advanced scientific research and innovation 1, no. 9 (2021): 169–77. http://dx.doi.org/10.53633/ijmasri.2021.1.9.02.

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The Pharmaceutical industry has become more interested in developing fixed-dose combinations (FDCs) in recent years. FDCs have been used successfully in a variety of clinical areas, including diabetes, HIV/AIDS,and cardiovascular diseases etc. FDCs are intended to extend the product life cycle and enhance patient compliance by decreasing cost. Active Pharmaceutical ingredients are chosen for FDC development based on variety of purposes such as Pharmacokinetic profile, drug-drug interactions, mechanism of action, and manufacturability for successful development. Tablet in tablet technology has

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Ekta, ,., Priyanshi Jain, Shailesh Jain, and Mohammed Azaz Khan. "Formulation and Evaluation of Extended Release Floating Matrix Tablet of Eperisone Hydrochloride by Direct Compression Method." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 86–92. http://dx.doi.org/10.22270/jddt.v9i3-s.2798.

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Increased complications and costs of marketing of innovative drugs focused greater attention to the development of sustained release (SR) or controlled release (CR) drug delivery systems. Delivery systems extended release or controlled release rate can achieve predictable and reproducible, the extended duration of activity for the short time of life - drugs, reduced toxicity and dose reduction request, the optimized therapy and better patient compliance. It is controlled primarily by the type and the proportion of the polymers used in the preparation. Eperisone hydrochloride is a centrally act

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Gaurav, Bhardwaj, Tak Kapil, Tanwar Y.S., Rathore R.P.S., and Choudhary Kuldeep. "Development and Evaluation of Extended Release Matrix Tablet of Metoprolol Succinate." Pharmaceutical and Chemical Journal 2, no. 3 (2015): 47–53. https://doi.org/10.5281/zenodo.13730216.

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The objective of this study was to design and evaluate oral sustained drug delivery system for metoprolol succinate using hydrophilic polymers such as HPMC K4M and HPMC K100M batches. Four batches were prepared by using HPMC K4M in drug: polymer ratio of 1:1, 1:1.5, 1:2, 1:3 and five batches using HPMC K100M in ratios of 1:1, 1:1.25, 1:1.5, 1:1.75, 1:2. Further formulation F9 was modified by varying the ratios of diluents i.e. F10, F11, F12, F13 to check the effect of diluents on drug release. Matrix tablets were prepared by wet granulation method and were evaluated for weight variation, conte

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Kapil Jalodiya, Sourabh Jain, and Karunakar Shukla. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. http://dx.doi.org/10.30574/gscbps.2020.13.1.0310.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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Kapil, Jalodiya, Jain Sourabh, and Shukla Karunakar. "Formulation and evaluation of gastro-retentive floating tablets of terbinafine." GSC Biological and Pharmaceutical Sciences 13, no. 1 (2020): 257–66. https://doi.org/10.5281/zenodo.4264695.

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Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of terbinafine were prepared by direct compression method using altered conc

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Malasiya, Rahul, and Tarkeshwar P. Shukla. "Formulation development and evaluation of gastroretentive mucoadhesive tablets of glimepiride using natural polymers." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 153–59. http://dx.doi.org/10.22270/jddt.v10i4-s.4264.

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Glimepiride, a third-generation sulfonylurea is poorly soluble anti-diabetic drug. Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations as valuable drug excipients. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. The development of mucoadhesive sustained release drug delivery system is recommended in order to enhance the bioavailability. A mucoadhesive tablets were developed using the natural polymer sodium alginate and gum tragacanth. Mucoadhesion is a complex phenomenon which involves wet

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Ashish, Sonawane* Yashpal More Vaibhav Patil. "Formulation And Assessment of Oral Gel for The Treatment of Mouth Ulcer Using Extract from Jamun Seed Powder." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3566–74. https://doi.org/10.5281/zenodo.15478930.

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A new era in the successful creation of controlled release formulations with many properties to offer an effective drug delivery mechanism began with the introduction of bilayer tablets. Bilayer tablets are superior to conventional mouthwash, sprays, and gels. Therefore, using a bilayer pill for analgesic and anti-inflammatory purposes is rather different. Two incompatible substances can be separated using bi-layer tablets, two treatments can be released successively, or sustained release tablets with an immediate release dose in the first layer and a maintenance dose in the second layer can b

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Hirun, Namon, and Pakorn Kraisit. "Drug-Polymers Composite Matrix Tablets: Effect of Hydroxypropyl Methylcellulose (HPMC) K-Series on Porosity, Compatibility, and Release Behavior of the Tablet Containing a BCS Class I Drug." Polymers 14, no. 16 (2022): 3406. http://dx.doi.org/10.3390/polym14163406.

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The purpose of this research was to see how the physicochemical properties and porosity of matrix tablets containing various types of hydroxypropyl methylcellulose (HPMC) K series affected the release of propranolol hydrochloride (PNL). PNL is a class I drug (high solubility and permeability) according to the Biopharmaceutics Classification System (BCS), making it an excellent model drug used for studying extended-release drug products. The direct compression method was used to prepare the HPMC-based matrix tablets. PNL and the excipients were found to be compatible using Fourier transform inf

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Amer, Sarah K., Walaa Alaa, and AG Eshra. "HPMC Extended-Release Multi-Composite Matrix for Co-delivery of Oxcarbamazepine and Vitamin D." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1474–78. http://dx.doi.org/10.25258/ijpqa.15.3.59.

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Background: Carbamazepine (CBZ) is considered as first-line treatment for epilepsy. The literature has signified a history of non-uniform drug performance and clinical failures. However, many studies suggested that Oxcarbazepine (OXC), a structural analog of CBZ, may have an equivalent antiepileptic effect. OXC follows a different metabolic pathway other than CBZ. However, both share the same mechanism of action by blocking voltage-gated sodium channels. Objectives: This study aimed to form hydroxypropyl methylcellulose (HPMC) extended-release tablets containing OXC combined with vitamin D. Me

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Soni, Nikita, Deepak Joshi, Vikas Jain, and Pradeep Pal. "A Review on Applications of Bilayer Tablet Technology for Drug Combinations." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 222–27. http://dx.doi.org/10.22270/jddt.v12i1.5206.

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Bilayer tablets are novel drug delivery systems where combination of two drugs in a single unit having different release profiles can be delivered. Bilayer tablets improve patient compliance, prolong the drug(s) action and can deliver two incompatible drugs in a single formulation. Bilayer tablets have one layer of active ingredient for immediate release and a second layer for delayed release, either as a second dose or in an extended release fashion. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology i

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Jaimini, Rohit, Manish K. Gupta, and Vijay Sharma. "A Review on Formulation and Evaluation of Gastroretentive Floating Tablet of Nifedipin." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 651–56. http://dx.doi.org/10.22270/jddt.v9i4.3065.

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Different mass transport processes may occur during drug release from polymer-based matrix tablets, including water imbibition into the system, polymer swelling, drug dissolution, drug diffusion out of the tablet, and polymer dissolution. Depending on the type of drug, polymer and release medium and on the tablet composition, the respective processes are more or less important. Velasco et al.24 reported that the rate and mechanism of nifidipine release from HPMC K15M-based matrices were mainly controlled by the drug/ HPMC ratio, and that drug release was independent of the compression force in

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Chang, Cuihua, Ali Ahmad Leghari, Xin Li, et al. "Konjac gum and maltodextrin compound tablets as carriers of IgY for sustained release in stomach." International Food Research Journal 30, no. 5 (2023): 1297–303. http://dx.doi.org/10.47836/ifrj.30.5.17.

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Egg yolk immunoglobulin (IgY) is a biologically active ingredient with high immunogenicity; however, its instability in the acidic environment of the upper gastrointestinal tract limits its application in oral formulations. In the present work, an encapsulation system based on maltodextrin (MD) and konjac gum (KGM) was developed as a protective carrier for IgY for targeted release to retain stability. A simulated gastric model was used to compare the release characteristics of the different formulations, and to explore the optimal release mode. To better understand the controlled release mecha

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Solanki, Dharmendra, and Mohit Motiwale. "Studies on Drug Release Kinetics and Mechanism from Sustained Release Matrix Tablets of Isoniazid using Natural Polymer Obtained from Dioscorea Alata." International Journal of ChemTech Research 13, no. 3 (2020): 166–73. http://dx.doi.org/10.20902/ijctr.2019.130313.

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Sustained-release (SR) matrix tablets of Isoniazid and polysaccharide isolated from tubers of Dioscorea alata, at different drug to polymer ratios, were prepared by using wet granulation method. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. The investigation focuses on the influence of the proportion of the matrix material on the mechanism and the release rate of the drug from the tablets. In vitro drug release appears to occur both by diffusion and a swellingcontrolled mechanism, indicates the drug release from

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Solanki, Dharmendra, Mohit Motiwale, and Sujata Mahapatra. "Study of Drug Release Kinetics from Sustained Release Matrix Tablets of Acyclovir using Natural Polymer Obtained from Colocasia Esculenta." International Journal of PharmTech Research 13, no. 3 (2020): 172–79. http://dx.doi.org/10.20902/ijptr.2019.130306.

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Sustained-release (SR) matrix tablets of Acyclovir and polysaccharide isolated from corms of Colocasia esculenta, at different drug to polymer ratios, were prepared by using wet granulation method. The formulated tablets were also characterized by physical and chemical parameters and results were found in acceptable limits. The investigation focuses on the influence of the proportion of the matrix material on the mechanism and the release rate of the drug from the tablets. In vitro drug release appears to occur both by diffusion and a swelling-controlled mechanism, indicates the drug release f

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Tambe, Sujit T., Harshad B. Padekar, S. M. Dhobale, and S. L. Jadhav. "Design and Characterisation of Bi-layer Tablets Containing Simvastatin as Sustained Release and Labetalol HCl as Immediate Release." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 263–70. http://dx.doi.org/10.22270/jddt.v9i2-s.2508.

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The objective of present investigation is to design and characterise sustained release Simvastatin and immediate release of Labetalol HCl, a bi-layer tablet. The combination therapy of Simvastatin and Labetalol HCl can be useful in severe cardiovascular disease such as hypertension, angina pectoris, congestive heart failure which may occur along with increasing cholesterol level in the blood, while this combination remain preferable choice to the patient as compared to single dosage form. The bi-layer tablet is suitable for sequential release of two drugs in combination which are compatible wi

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Chareonying, Thapakorn, Prasert Akkaramongkolporn, and Praneet Opanasopit. "Development of Floating 3D-Printed Devices for Carvedilol Tablet." Key Engineering Materials 914 (March 21, 2022): 45–51. http://dx.doi.org/10.4028/p-fgf5qq.

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A floating drug delivery device is one type of gastro-retentive drug delivery system (GRDDS). Carvedilol (CAR) is poorly soluble in alkaline pH (intestinal environment) and has good solubility in the acidic pH (stomach environment). Hence, floating 3D-printed devices (FD) were developed from polylactic acid (PLA) filaments using fused deposition modeling (FDM) and designed to be a tablet shape with an anti-flip-up property as GRDDS of carvedilol tablets. There were two parts of FD, including the cap and the base. The base was designed with different hole diameters (2.5, 3.5, and 4.5 mm) for a

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Mudrić, Jelena, Ljiljana Đekić, Nemanja Krgović, et al. "Dual-Mechanism Gastroretentive Tablets with Encapsulated Gentian Root Extract." Pharmaceutics 17, no. 1 (2025): 71. https://doi.org/10.3390/pharmaceutics17010071.

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Background/Objectives: This study aimed to develop gastroretentive tablets based on mucoadhesive–floating systems with encapsulated gentian (Gentiana lutea, Gentianaceae) root extract to overcome the low bioavailability and short elimination half-life of gentiopicroside, a dominant bioactive compound with systemic effect. The formulation also aimed to promote the local action of the extract in the stomach. Methods: Tablets were obtained by direct compression of sodium bicarbonate (7.5%) and solid lipid microparticles (92.5%), which were obtained with lyophilizing double emulsions. A quality by

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Kriangkrai, Worawut, Satit Puttipipatkhachorn, Pornsak Sriamornsak, and Srisagul Sungthongjeen. "Design and Evaluation of New Gel-Based Floating Matrix Tablets Utilizing the Sublimation Technique for Gastroretentive Drug Delivery." Gels 10, no. 9 (2024): 581. http://dx.doi.org/10.3390/gels10090581.

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A gel-based floating matrix tablet was formulated and evaluated using the sublimation technique to enhance gastroretentive drug delivery. Anhydrous theophylline was employed as the active pharmaceutical ingredient, combined with sublimation agents and hydroxypropyl methylcellulose as the gel-forming polymer. The resulting tablets exhibited high porosity, immediate floatation, and sustained buoyancy for over 8 h. Optimization of the floating behavior and drug release profiles was achieved by adjusting the viscosity of and hydroxypropyl methylcellulose and the concentration of sublimation agents

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Kanke, Pralhad K., Pankaj Sawant, Ajit Jadhav, and Md Rageeb Md Usman. "A REVIEW ON DISINTEGRATION CONTROL MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 19–22. http://dx.doi.org/10.22270/jddt.v8i5.1852.

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A number of sustained release formulations are available in the market which successfully sustained the drug release over a prolonged period of time by different mechanisms. The new approach for sustaining the drug release is disintegration control matrix tablet which sustained the drug release up to 24hrs by controlling the disintegration rate of tablet. Disintegration control matrix tablet (DCMT) mainly forms the granules containing drug and disintegrating agent such as low substituted hydroxyl propyl cellulose by various methods such as solid dispersion technique. The sustained release of d

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Kabir, Abul Kalam Lutful, Shimul Halder, Madhabi Lata Shuma, and Abu Shara Shamsur Rouf. "Formulation Development and in vitro Evaluation of Drug Release Kinetics from Sustained Release Aceclofenac Matrix Tablets using Hydroxypropyl Methyl Cellulose." Dhaka University Journal of Pharmaceutical Sciences 11, no. 1 (2012): 37–43. http://dx.doi.org/10.3329/dujps.v11i1.12485.

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The objective of the present study was to develop a once-daily sustained release matrix tablet of Aceclofenac using hydroxypropyl methyl cellulose (Methocel K 100M CR) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by direct compression method. The powder blends were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content etc. The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in vitro

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Alam, Md Shamsul, Jakir Ahmed Chowdhury, Sams Mohammad Anowar Sadat, and Md Selim Reza. "Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose Microcapsules using Emulsion Solvent Evaporation Technique." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 132–36. http://dx.doi.org/10.3329/bpj.v18i2.24311.

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Ethyl cellulose (EC) microcapsules containing Salbutamol sulphate (SS) were prepared through emulsion-solvent evaporation technique. Microcapsules were compressed and in-vitro release profiles were studied from both microcapsules and their compressed matrix tablets. Different amounts of drug were added in order to obtain various drugs to polymer ratios and it was found that the size of microcapsules reduced with the increase in core loading. In the preparation of formulations, Tween 80 was used as an emulsifying or dispersing agent and light liquid paraffin (LLP) was used as oil phase. The in-

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Mondal, Nita. "THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM." International Journal of Applied Pharmaceutics 10, no. 1 (2018): 1. http://dx.doi.org/10.22159//ijap.2018v10i1.21935.

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Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controll

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Kasperek, Regina, Lukasz Zimmer, Maria Zun, Dorota Dwornicka, Katarzyna Wojciechowska, and Ewa Poleszak. "The application of povidone in the preparation of modified release tablets." Current Issues in Pharmacy and Medical Sciences 29, no. 2 (2016): 71–78. http://dx.doi.org/10.1515/cipms-2016-0015.

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Abstract The aim of the study was to investigate the modified release of a model substance, of tablets containing different types of Kollidon and particular additives. Additionally, the release kinetics and mechanism of prolonged release of certain tablet preparations were investigated. In this work, tablets containing different types of povidone (Kollidon CL, Kollidon 30, Kollidon SR and other excipients) were prepared by the direct compression technique. The results showed that tablets with fast disintegration and release should contain in their composition, Kollidon CL, lactose and Avicel,

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Thapa, Prakash, and Seong Jeong. "Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach." Pharmaceutics 10, no. 3 (2018): 161. http://dx.doi.org/10.3390/pharmaceutics10030161.

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To develop sustained release gastro-retentive effervescent floating tablets (EFT), a quality-based experimental design approach was utilized during the composing of a hydrophilic matrix loaded with a high amount of a highly water-soluble model drug, metformin HCl. Effects of the amount of polyethylene oxide WSR 303 (PEO), sodium bicarbonate, and tablet compression force were used as independent variables. Various times required to release the drug, tablet tensile strength, floating lag time, tablet ejection force, and tablet porosity, were selected as the responses. Polymer screening showed th

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Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

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Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

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Chongcherdsak, Noppadol, Direk Aekthammarat, Teerayuth Prathumchat, Chutima Limmatvapirat, and Sontaya Limmatvapirat. "Fabrication of Shellac-Zein Based Matrix Tablet as a Carrier for Controlling of Drug Release." Advanced Materials Research 1060 (December 2014): 50–53. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.50.

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The aim of research was to fabricate shellac-zein composite polymer-based matrix tablets by using theophylline as a model drug. The tablets were prepared by direct compression process. The initial weight and hardness of tablets were controlled within the range of 300±5 mg and 60±10 N, respectively. The tablets were annealed at 80 °C for 24 h and kept in the ambient temperature before evaluation. Drug release profile and kinetics of drug release in 0.1 N HCl and buffer pH 6.8 were investigated. The result showed that the annealing process and shellac:zein ratio, affected drug release characteri

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Deshpande, Amar H., and Wasul D. "DESIGN AND EVALUATION OF FOOD GRADE WAX MATRIX SUSTAINED RELEASE MINI-TABLETS OF MONTELUKAST SODIUM." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 317. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16788.

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Objective: The objective of this study is to formulate a tablet that fits in the size range of mini-tablets using wax matrix forming substances, allowsvariation of drug dose and study of drug release kinetics of the dosage form.Methods: The blends of drug with glyceryl monostearate, purified rice bran wax and carnauba wax that renders the waxes food grade, were preparedand evaluated for precompression characteristics. The blends were compressed into mini-tablets having desirable physical characteristics andwere subjected to tests such as weight variation and friability. The tablets were subjec

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