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Dissertations / Theses on the topic 'Mechanisms of anticonvulsant activity'

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Published: 7 June 2025

Last updated: 2 August 2025

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1

Masoud, Khalid. "Investigation of some possible mechanisms involved in the anticonvulsant activity of Tulbaghia violacea harv." University of the Western Cape, 2015. http://hdl.handle.net/11394/5333.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the plant species in therapy. This project was intended, therefore, to investigate the anticonvulsant effect of the leaf methanol extract of Tulbaghia violacea by studying its effect against tonic convulsion induced by either pentylenetetrazole (PTZ), bicuculline, picrotoxin, strychnine or N-methyl-DL-aspartic acid (NMDLA) in m

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2

Koubanakis, Miltiadis. "The use of the Retzius cells of the leech Hirudo medicinalis as a possible model for studying the underlying mechanism of epileptiform activity." Thesis, University of Portsmouth, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310136.

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3

Acheampong, Andrew Adu. "Quantitative structure-anticonvulsant activity studies of valproic acid analogues." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25552.

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Valproic acid (2-propylpentanoic acid) is an antiepileptic drug widely used for treatment of absence seizures. Valproic acid has a unique chemical structure which does not contain the imide structure found in most conventional antiepileptic drugs. An in vivo study of the antagonism of pentylenetetrazol-induced clonic seizures by alkyl-substituted carboxylic acids and tetrazoles was of interest owing to the known bioisosterism between the carboxylic and the tetrazolyl moiety. The main objective of this study was to investigate the role played by the lipophilicity, the electronic properties and

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4

Iyamu, Osaro. "Evaluation of the anticonvulsant activity of Elytropappus rhinocerotis (L.f) Less." University of the Western Cape, 2016. http://hdl.handle.net/11394/5872.

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Magister Pharmaceuticae - Mpharm<br>M.Pharm thesis, Discipline of Pharmacology, School of Pharmacy, University of the Western Cape. Epilepsy is a worldwide neurological disorder which is also prevalent in South Africa. Herbal medicines, besides orthodox medicines, have been used from time immemorial for the treatment of epilepsy even though, generally, there is want of scientific evidence to substantiate their effectiveness. People with epilepsy have used different types of plants and herbs now known as herbal therapies over thousands of years although no clinical benefit is implied by this te

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5

Kotcharaksa, Komgrit. "The Mechanisms, Products, and Kinetic of Carbamazepine-Free Chlorine Reactions." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/36422.

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Carbamazepine (CBZ) is an antiepileptic drug widely detected in drinking water supplies and wastewater effluent. It has been previously found that CBZ is recalcitrant to biological removal processes. Therefore, active CBZ will be exposed to wastewater effluent disinfection processes, which for most treatment plants in the United States involves the addition of free chlorine. However, the chlorination mechanisms of CBZ have not been fully investigated and are currently poorly understood. Our experimental studies were conducted to examine the chlorination of CBZ under controlled conditions. The

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6

Muhizi, Theoneste. "The extraction, purification and evaluation of compounds from the leaves of Leonotis Leonorus for anticonvulsant activity." Thesis, University of the Western Cape, 2002. http://hdl.handle.net/11394/1609.

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Magister Scientiae - MSc<br>The aim of this study is to isolate and evaluate the anticonvulsant components from the leaves of Leonotis leonorus (L) R.aR. and to see if there is any change in activity with the origin of the plant material and I or the season in which plant material is collected. Therefore, in this study, two sites were chosen for collection of plant material and the collection was made in summer and in winter. Chemical, physical and pharmacological methods were used to isolate, identify and to evaluate compounds isolated from the leaves of Leonotis leonorus for anticonvulsant a

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7

Bijur, Gautam N. "Molecular mechanisms of ascorbic acid activity /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487947908402857.

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8

Rohde, John Roy. "Multiple mechanisms regulate the activity of Gal4." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ56607.pdf.

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9

Planck, Anders. "Sarcoidosis : inflammatory mechanisms and markers of activity /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-355-4/.

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10

Billinghurst, Lori L. "Effects of some novel anticonvulsant drugs on the synchronous activity recorded in the presence of 4-aminopyridine in the rat hippocampus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/MQ29657.pdf.

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11

Billinghurst, Lori L. "Effects of some novel anticonvulsant drugs on the synchronous activity recorded in the presence of 4-aminopyridine in the rat hippocampus." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27283.

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Despite advances in understanding the pathogenesis of epilepsy, it remains a significant therapeutic challenge. Studies of the novel antiepileptic drugs (AEDs) gabapentin, lamotrigine and topiramate suggest that they will aid in managing seizures refractory to more established agents. However, a consensus has not been reached on their respective cellular and molecular mechanisms of action. Moreover, only a limited number of studies have examined the effects of these drugs in infants and children, a patient population with a particular propensity for seizure generation. Therefore, the objective

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12

Khouja, Ahmad Yassin. "Mechanisms of prostanoid production : regulation of phospholipase activity." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335838.

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13

Mockridge, James William. "Immunomodulation of GH activity : application and potential mechanisms." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627200.

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14

Morris, Gareth Liam. "Mechanisms of high frequency activity in epileptic foci." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5753/.

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High frequency activity (HFA) is oscillatory brain activity faster than ~100 Hz. It is subdivided into physiological ripples (~100-250 Hz) and pathological fast ripples (~250-500 Hz). Ripples in the hippocampus are paced by recurrent inhibition from interneurons. The mechanism for pathological HFA is unknown, but may be the same as for ripples and could provide new insight into the pathological nature of epileptic tissue. HFA was induced using the high potassium (\({in vitro}\)) and tetanus neurotoxin (\({ex vivo}\)) models of epilepsy. Field HFA was recorded simultaneously with action potenti

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15

Reis, Gerald Feliz. "Mechanisms of motor activity regulation in axonal transport." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3315202.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed Nov. 5, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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16

Blankenship, Aaron Gregory. "Mechanisms underlying spontaneous activity in the developing retina /." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3371948.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed Jan. 7, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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17

chang, lei. "YAP/TAZ ACTIVITY AND MECHANISMS OF CELL PLASTICITY." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424489.

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In the last few years, YAP/TAZ emerged as powerful regulators of growth and tumor malignancy. YAP/TAZ are regulated by two inputs: the Hippo pathway and biomechanical pathway. The latter involves structural and physical signals that cells receive from their being attached to the substrate and/or to other cells and that chance the tension and organization of the cytoskeleton and cell shape. In previous works from our laboratory, we indeed found that specific F-actin structures, such as bundled F-actin cables and stress fibers are required to sustain YAP/TAZ activity. But the cascade intervening

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18

Meekins, David A. "Structural Mechanisms of Glucan Phosphatase Activity in Starch Metabolism." UKnowledge, 2014. http://uknowledge.uky.edu/biochem_etds/14.

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Starch is a water-insoluble glucose biopolymer used as an energy cache in plants and is synthesized and degraded in a diurnal cycle. Reversible phosphorylation of starch granules regulates the solubility and, consequentially, the bioavailability of starch glucans to degradative enzymes. Glucan phosphatases release phosphate from starch glucans and their activity is essential to the proper diurnal metabolism of starch. Previously, the structural basis of glucan phosphatase activity was entirely unknown. The work in this dissertation outlines the structural mechanism of activity of two plant glu

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19

Burbridge, Timothy James. "Molecular and Activity-Dependent Mechanisms of Visual Circuit Development." Thesis, Yale University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3663626.

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<p> The construction and refinement of early neuronal circuits is fundamentally relevant to adult brain function, developmental disorders, and learning and plasticity, but only a small part of this process is well understood (Cang and Feldheim, 2013; Ebert and Greenberg, 2013). A significant and long-standing debate in the field concerns the relative contributions of "hardwired" genetic and molecular determinants versus "plastic" environment and activity-driven alterations (Cline, 2003). While circuits are largely hardwired in most insect and invertebrate species (Hiesinger, 2006), the mammali

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20

Commane, Daniel. "The mechanisms involved in the anticarcinogenic activity of probiotics." Thesis, University of Ulster, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414097.

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21

Kurtz, Lisa Miriam. "Molecular mechanisms integrating genetic and calcium activity-dependent neurotransmitter specification." Diss., [La Jolla, Calif.] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3397122.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed March 29, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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22

Liang, Huamin. "Ionic mechanisms underlying pacemaker activity in the murine embryonic heart /." Köln, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000264348.

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23

Ilkovitch, Dan. "Mechanisms Involved in the Anti-Tumor Activity of MUC1/sec." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/250.

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The transmembrane isoform of mucin 1 (MUC1/TM) is a well recognized tumor antigen, contributing to tumorigenesis and immune evasion. While MUC1/TM has been correlated with malignancy, it appears that a secreted splice variant of MUC1 (MUC1/sec) has antitumor properties and prevents tumor development. It was discovered that MUC1/sec expressing tumor cells (DA-3/sec) have a significant reduction in expression of urokinase plasminogen activator (uPA) relative to the parental tumor line, and tumor cells expressing MUC1/TM (DA-3/TM). The serine protease uPA, has been found to be involved in grow

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24

Bühler, Anja [Verfasser]. "Molecular mechanisms regulating phospholipase C-gamma 2 activity / Anja Bühler." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2016. http://d-nb.info/1094889202/34.

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25

Selin, Carrie Lynn. "Regulatory Mechanisms Underlying Biological Control Activity of Pseudomonas chlororaphis PA23." FEMS Microbial Ecology, 2010. http://hdl.handle.net/1993/9144.

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Biological control is an intriguing alternative to the use of chemical pesticides as it represents a safer, more environmentally friendly approach to managing plant pathogens. Pseudomonas chlororaphis strain PA23 was isolated from soybean root tips and it was found to be an excellent antagonist of sclerotinia stem rot. Our studies have shown that pyrrolnitrin (PRN) is the key metabolite required for S. sclerotiorum inhibition, while phenazine (PHZ) is important for biofilm establishment. For this reason, research efforts were directed towards elucidating the mechanisms governing PA23-mediate

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26

Zhang, Qingbei. "MOLECULAR MECHANISMS THAT MEDIATE METASTASIS SUPPRESSOR ACTIVITY OF NM23-H1." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/410.

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Metastasis is the spread of cancer cells from the primary tumor to distant sites. It is the most dangerous attribute of cancer, and also the principle cause of cancerrelated morbidity and mortality. Metastasis suppressor genes are a group of genes that suppress tumor metastasis without significant effect on tumorigenicity. NM23 was the first identified metastasis suppressor gene, and loss of its expression is a frequent hallmark of metastatic growth in multiple cancers (e.g. melanoma, carcinomas of breast, stomach and liver). NM23-H1 possesses at least three enzymatic activities, including nuc

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27

Rosser, A. E. "Neural and neuroendocrine mechanisms of pheromonal activity in female mice." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372912.

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28

Kissane, Roger William Peter. "Animal models of exercise therapy : mechanisms of activity-induced angiogenesis." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/17587/.

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Skeletal muscle is spatially heterogeneous in muscle fibre type composition and microvascular supply. The capacity to quantify this heterogeneity in skeletal muscle is not routinely performed for it’s a laborious and time consuming technique. We have developed a high throughput data pipeline that utilises the simultaneous immunohistochemical labelling of muscle fibre type and microvascular supply, as an input for a semi-automated analysis software package that allows for the analysis of fine morphometric indices of fibre type composition and the interactions with microvascular supply. We have

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29

Blanco, Touriñán Noel. "New mechanisms of DELLA protein regulation and activity in Arabidopsis." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/149477.

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[EN] DELLA proteins are plant-specific transcriptional regulators known to relay environmental information to the transcriptional networks to modulate growth and development accordingly. The view of DELLAs as signalling hubs is justified by two characteristics: first, they control the activity of a large number of transcriptional factors (TFs) and other transcriptional regulators through physical interaction; and, second, they are degraded by the 26S proteasome in response to the phytohormone gibberellin (GA), whose metabolism is very sensitive to environmental stimuli (e.g. light, temperature

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30

DARDAEI, ALGHALANDIS LEILA. "UNRAVELING MOLECULAR MECHANISMS UNDERLYING MEIS1ONCOGENIC ACTIVITY; POSSIBLE COMPETITION WITH PREP1." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219063.

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Meis1 and Prep1 homeodomain-containing transcription factors are essential for the normal embryonic development of several tissues and organs. Although they both can recruit Pbx at least for some of their biological function using the same homology region, the Meis1-Pbx and Prep1-Pbx complexes bind different DNA sequences and play opposite roles in tumorigenicity. In cancer, Meis1 has been extensively implicated in leukemia and neuroblastoma. Overexpression of Meis1 greatly shortens the latency and affects the penetrance of myeloid leukemia induced by Hox genes retroviral transduction. Further

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31

Ke, Ying, and n/a. "Mechanisms by which COMMD1 down-regulates Epithelial Sodium Channel (ENaC) activity." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081205.161914.

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The epithelial sodium channel (ENaC) made up of α, β and γ subunits is located at the apical membrane of polarised epithelia and mediates transport of sodium ions into the cells. Tight control of ENaC function is essential for maintaining sodium homeostasis, blood volume and blood pressure. Controlling the number of active channels present at the cell surface appears to be critically important in regulating ENaC activity. The neural precursor cell expressed developmentally down-regulated gene 4 (Nedd4) family of proteins (eg. Nedd4-2) ubiquitinate ENaC and decrease its cell surface expression.

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32

Sawer, Ishmael Kwabla. "Antimicrobial activity of Cryptolepis sanguinolenta and mechanisms of action of cryptolepine." Thesis, Liverpool John Moores University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262247.

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33

Piccioli, Zachary D. (Zachary David). "Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/89946.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we characterized this dynamic process and demonstrate that rapid bouton budding requires retrograde BMP signaling and local alteration in the presynaptic actin cytoskeleton. BMP acts during development to provide compete

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34

Waermö, Mimmi. "Dialectics of Negotiagency : Micro Mechanisms in Children’s Negotiation in Play Activity." Doctoral thesis, Stockholms universitet, Institutionen för pedagogik och didaktik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-140954.

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This study is about the children in a fourth and fifth grade Swedish primary school class and their play during breaktimes. The study takes the theoretical point of departure in seeing children’s breaktime play as a cultural historical activity. The overarching research problem concerns breaktime play emphasising the phenomena of children’s negotiation, participation and agency. It concerns how breaktime play takes shape and which capacities children possess, who are breaktime play literate, to participate and to uphold play. What is the significance of children’s capacity to negotiate rules a

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35

Long, Xinghua. "Novel mechanisms underlying antiestrogen activity and antiestrogen resistance in breast cancer." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307565.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2008.<br>Title from dissertation home page (viewed Dec. 9, 2008). Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2835. Adviser: Kenneth P. Nephew.

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36

Waters, Catherine M. "The mechanisms underlying the anti-cancer activity of substance-P analogues." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23248.

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This study explores the range of tumour types, which are sensitive to substance P analogues. It was found that a wider range of tumour types than had been previously demonstrated were sensitive to growth inhibition by the substance P analogue, [Arg6,D-Trp7,9,NmePhe8]- Substance P(6-11) (antagonist G). Sensitive tumour types included SCLC, NSCLC, colo-rectal and ovarian tumour cell lines with a mean IC50 value of 33mM for 11 tumour cell lines of various origin. The mechanism of action of the growth inhibitory effects of substance P analogues is unclear. Using RT-PCR this study shows that sensit

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37

Chauvin, Jean-Philippe. "Elucidation of the Various Mechanisms of Antioxidant Activity of Organosulfur Compounds." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39675.

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Polysulfides, produced from olefin sulfurization, are common additives to various petroleum-derived products such as engine oils, hydraulic fluids, rubbers and polymeric materials in an effort to protect these materials from oxidative degradation. The mechanisms by which organosulfur compounds act as antioxidants are often described as ‘secondary antioxidants’ since it is believed that they slow the rate of radical initiation by decomposing hydroperoxides. Organosulfurs also figure in various natural products from the genus Allium, of which garlic is a prominent species. Our group previously s

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38

VITTORI, CECILIA. "MECHANISMS OF MIR-3189-3P-MEDIATED ANTITUMORAL ACTIVITY IN BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/842023.

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Background: Brest cancer is one of the most diffused tumors worldwide. In US, breast cancer represents 30% of all newly diagnosed cancers in female and remain the second leading cause of death, with new 281,550 diagnosed cases in women. Invasive breast cancer can be divided into four subtypes, among which HR+ is the most common and the less aggressive. On the contrary, TNBC is the most aggressive subtype and the one with the worst prognosis. TNBC is characterized by the lack of estrogen receptor, progesterone receptor, and HER2. Consequently, TNBC cannot be treated with the available hormone t

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39

Russo, Emilio. "Investigation of the mechanisms of action of the anticonvulsant topiramate : electrophysiological studies on rat olfactory cortical neurones in vitro and some in vivo rodent models of epilepsy." Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418003.

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40

Welt, Thomas. "Enzymatic deinking effectiveness and mechanisms." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/7067.

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41

Fu, Dechen. "The study of multiple mechanisms that regulate the transcriptional activity of Bicoid /." Cincinnati, Ohio University of Cincinnati, 2004. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1100790435.

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Chen, Roger. "Learning and risk perception mechanisms in route choice and activity scheduling dynamics." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/7400.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Civil Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Beilhartz, Gregory. "HIV-1 reverse transcriptase-associated ribonuclease H activity: novel mechanisms of inhibition." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110492.

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The reverse transcriptase (RT) of HIV-1 contains two active sites, polymerase and ribonuclease (RNase) H that are both absolutely necessary for viral replication and disease progression. While several drugs currently used in the clinic to treat HIV-1 target the polymerase activity of RT, none currently target the RNase H activity specifically. The work contained in this thesis describes a potential intrinsic biochemical obstacle to the development of the most common class of RNase H inhibitors, namely steric competition with the natural substrate. Two active site RNase H inhibitors are studied

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FU, DECHEN. "THE STUDY OF MULTIPLE MECHANISMS THAT REGULATE THE TRANSCRIPTIONAL ACTIVITY OF BICOID." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100790435.

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45

Chen, Yung-Ju. "Exploring the Mechanisms of Children’s Physical Activity Behavior on the School Playground." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159537253755685.

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46

Hagevik, André. "Brainstem and spinal cord mechanisms that control locomotor activity in larval lamprey /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9842533.

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47

Sheagley, Eric Eugene. "Mechanisms of transcription elongation and the nuclease activity of RNA polymerase II /." view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3080598.

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Thesis (Ph. D.)--University of Oregon, 2003.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 119-129). Also available for download via the World Wide Web; free to University of Oregon users.

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48

Allen, Erin Marie Gagan. "Mechanisms of Toxicity and the Structure-Activity Relationships of Molinate and Dieldrin." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/4808.

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Pesticides have been used to control various types of pests, including plants and insects, for thousands of years, however the impact of exposure to these toxic chemicals, with respect to environmental and health consequences, is not fully understood. Two pesticides of interest, molinate and dieldrin, have been shown to cause neurotoxicity in humans, but their mechanisms of toxicity are still unknown. In order to better understand how exposure to these chemicals can cause toxicity, the structure-activity relationship (SAR)

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49

Ranchio, Alessandro. "Structural studies of protein kinase CK2: Inhibition mechanisms and structure-activity relationships." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422666.

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The subject of this thesis is the protein kinase CK2 which is a family of enzymes that in humans consists of two catalytic subunits, termed CK2α and CK2α’, and one regulatory subunit, CK2β. CK2 is a highly conserved acidophilic Ser/Thr protein kinase, ubiquitously distributed in different cell compartments. CK2 is a member of the superfamily of eukaryotic protein kinases (EPKs), meaning the catalytic subunit is related by sequence homology and structural features to the other 478 kinases of the superfamily. CK2 shows some singular features like its high constitutive activity and the lack of

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50

Muhizi, ThÃ¨oneste. "The extraction, purification and evaluation of compounds from the leaves of Leonotis Leonorus for anticonvulsant activity." Thesis, 2002. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The aim of this study is to isolate and evaluate the anticonvulsant components from the leaves of Leonotis leonorus (L) R.aR. and to see if there is any change in activity with the origin of the plant material and I or the season in which plant material is collected. Therefore, in this study, two sites were chosen for collection of plant material and the collection was made in summer and in winter. Chemical, physical and pharmacological methods were used to isolate, identify and to evaluate compounds isolated from the leaves of Leonotis leonorus for anticonvulsant activity.

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