Relevant bibliographies by topics / Mechanisms of azole resistance

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Mechanisms of azole resistance'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Mechanisms of azole resistance"

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Sanglard, Dominique, and Alix T. Coste. "Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms." Antimicrobial Agents and Chemotherapy 60, no. 1 (2015): 229–38. http://dx.doi.org/10.1128/aac.02157-15.

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ABSTRACTIsavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole, itraconazole, posaconazole, and voriconazole.Saccharomyces cerevisiaeexpressing theCandida albicansandC. glabrataATP binding cassette (ABC) transporters (CDR1,CDR2, andCgCDR1), major facilitator (MDR1), and lanosterol 14-α-sterol-demethylase (ERG11) alleles with mutations
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Gonzalez-Jimenez, Irene, Jose Lucio, Jorge Amich, et al. "A Cyp51B Mutation Contributes to Azole Resistance in Aspergillus fumigatus." Journal of Fungi 6, no. 4 (2020): 315. http://dx.doi.org/10.3390/jof6040315.

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The emergence and spread of Aspergillus fumigatus azole resistance has been acknowledged worldwide. The main problem of azole resistance is the limited therapeutic options for patients suffering aspergillosis. Azole resistance mechanisms have been mostly linked to the enzyme Cyp51A, a target of azole drugs, with a wide variety of modifications responsible for the different resistance mechanisms described to date. However, there are increasing reports of A. fumigatus strains showing azole resistance without Cyp51A modifications, and thus, novel resistance mechanisms are being explored. Here, we
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Ghannoum, Mahmoud. "Azole Resistance in Dermatophytes." Journal of the American Podiatric Medical Association 106, no. 1 (2016): 79–86. http://dx.doi.org/10.7547/14-109.

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Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development. Although many published manuscripts describe resistance to azoles among yeast and molds, reports describing resistance of dermatophytes are starting to appear. In this review, I discuss the mode of action of azole antifungals and mechanisms underlying their resistance compared with the allylamine class of compounds. Data from published and
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Arikan-Akdagli, Sevtap, Mahmoud Ghannoum, and Jacques Meis. "Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus." Journal of Fungi 4, no. 4 (2018): 129. http://dx.doi.org/10.3390/jof4040129.

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Antifungal resistance is a topic of concern, particularly for specific fungal species and drugs. Among these are the multidrug-resistant Candida auris and azole-resistant Aspergillus fumigatus. While the knowledge on molecular mechanisms of resistance is now accumulating, further data are also available for the clinical implications and the extent of correlation of in vitro resistance to clinical outcomes. This review article summarizes the epidemiology of C. auris infections, animal models focusing on the activity of novel antifungal compounds in C. auris infections, virulence factors, and th
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MacCallum, Donna M., Alix Coste, Françoise Ischer, Mette D. Jacobsen, Frank C. Odds, and Dominique Sanglard. "Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection." Antimicrobial Agents and Chemotherapy 54, no. 4 (2010): 1476–83. http://dx.doi.org/10.1128/aac.01645-09.

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ABSTRACT Principal mechanisms of resistance to azole antifungals include the upregulation of multidrug transporters and the modification of the target enzyme, a cytochrome P450 (Erg11) involved in the 14α-demethylation of ergosterol. These mechanisms are often combined in azole-resistant Candida albicans isolates recovered from patients. However, the precise contributions of individual mechanisms to C. albicans resistance to specific azoles have been difficult to establish because of the technical difficulties in the genetic manipulation of this diploid species. Recent advances have made genet
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Marichal, P., and H. Vanden Bossche. "Mechanisms of resistance to azole antifungals." Acta Biochimica Polonica 42, no. 4 (1995): 509–16. http://dx.doi.org/10.18388/abp.1995_4904.

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Until the late eighties, clinical resistance to azole antifungals was a rare phenomenon. Only a few cases of resistance to ketoconazole were found in patients with chronic mucocutaneous candidiasis (CMC). The spread of AIDS and the widespread prophylactic and therapeutic use of the hydrophilic azole compound fluconazole resulted both in the selection and induction of resistant strains and in a shift in the nature of the infecting organisms. Most azole antifungals such as itraconazole, ketoconazole and fluconazole are active against a variety of fungal diseases. However, the concentration neede
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Vandeputte, Patrick, Gérald Larcher, Thierry Bergès, Gilles Renier, Dominique Chabasse, and Jean-Philippe Bouchara. "Mechanisms of Azole Resistance in a Clinical Isolate of Candida tropicalis." Antimicrobial Agents and Chemotherapy 49, no. 11 (2005): 4608–15. http://dx.doi.org/10.1128/aac.49.11.4608-4615.2005.

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ABSTRACT Azole resistance has been insufficiently investigated in the yeast Candida tropicalis. Here we determined the molecular mechanisms responsible for azole resistance in a clinical isolate of this pathogenic yeast. Antifungal susceptibility testing performed by a disk diffusion method showed resistance or markedly decreased susceptibility to azoles, which was confirmed by determination of MICs. Considering the relationship between azole susceptibility and the respiration reported for other yeast species, the respiratory activity of this isolate was investigated. Flow cytometry using rhod
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Coste, Alix, Anna Selmecki, Anja Forche, et al. "Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates." Eukaryotic Cell 6, no. 10 (2007): 1889–904. http://dx.doi.org/10.1128/ec.00151-07.

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ABSTRACT TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a wild-type TAC1 allele drives high expression of CDR1/2 in response to inducers, we showed previously that TAC1 can be hyperactive by a gain-of-function (GOF) point mutation responsible for constitutive high expression of CDR1/2. High azole resistance levels are achieved when C. albicans carries hyperactive alleles only as a consequence of loss of heterozygosity (LOH) at the TAC1 locus on chromosome 5 (Chr
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Perea, Sofia, José L. López-Ribot, William R. Kirkpatrick, et al. "Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients." Antimicrobial Agents and Chemotherapy 45, no. 10 (2001): 2676–84. http://dx.doi.org/10.1128/aac.45.10.2676-2684.2001.

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ABSTRACT Molecular mechanisms of azole resistance in Candida albicans, including alterations in the target enzyme and increased efflux of drug, have been described, but the epidemiology of the resistance mechanisms has not been established. We have investigated the molecular mechanisms of resistance to azoles inC. albicans strains displaying high-level fluconazole resistance (MICs, ≥64 μg/ml) isolated from human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis. The levels of expression of genes encoding lanosterol 14α-demethylase (ERG11) and efflux transporters (MD
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Meis, Jacques F., Anuradha Chowdhary, Johanna L. Rhodes, Matthew C. Fisher, and Paul E. Verweij. "Clinical implications of globally emerging azole resistance in Aspergillus fumigatus." Philosophical Transactions of the Royal Society B: Biological Sciences 371, no. 1709 (2016): 20150460. http://dx.doi.org/10.1098/rstb.2015.0460.

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Aspergillus fungi are the cause of an array of diseases affecting humans, animals and plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and posaconazole are treatment options against diseases caused by Aspergillus . However, resistance to azoles has recently emerged as a new therapeutic challenge in six continents. Although de novo azole resistance occurs occasionally in patients during azole therapy, the main burden is the aquisition of resistance through the environment. In this setting, the evolution of resistance is attributed to the widespread use of azole-b
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Dissertations / Theses on the topic "Mechanisms of azole resistance"

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Marichal, Patrick. "Molecular mechanisms of azole resistance in human pathogenic fungi." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6858.

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Bueid, Ahmed. "Laboratory epidemiology and mechanisms of azole resistance in Aspergillus fumigatus." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/laboratory-epidemiology-and-mechanisms-of-azole-resistance-in-aspergillus-fumigatus(cfaa6ee2-36d5-473c-9531-816d9578ff17).html.

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Although A. fumigatus strains are generally susceptible to azoles, recently, acquired resistance to a number of antifungal compounds has been reported, especially to triazoles possibly due to widespread clinical use of triazoles or through exposure to azole fungicides in the environment. The significant clinical problem of azole resistance has led to study the antifungal resistance mechanisms for developing effective therapeutic strategies. Of 230 clinical A. fumigatus isolates submitted during 2008 and 2009 to the Mycology Reference Centre Manchester, UK (MRCM), 64 (28%) were azole resistant
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Pérez, Cantero Alba. "Study and characterization of azole resistance in Aspergillus section Nigri." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/670198.

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Algunes espècies d'Aspergillus mostren gran rellevància clínica com a patògens oportunistes que s'associen a gran varietat de malalties humanes. Entre elles, l'aspergil·losi invasiva és la més severa en termes de morbiditat i mortalitat. Tot i que Aspergillus fumigatus és l'agent causal més comú d'aquesta infecció, recentment s'ha reportat una elevada prevalència clínica d'altres espècies, com els membres de la secció Nigri. Malgrat que el tractament d'elecció actual per l'aspergil·losi és el voriconazol, la resistència a azols ha augmentat de manera alarmant, cosa que comporta gran impacte
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Howard, Susan J. "Azole Resistance in Aspergillus." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503743.

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Albarrag, Ahmed. "Azole resistance in clinical isolates of Aspergillus fumigatus." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487927.

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Aspergillus fil1nigatus is the most common aetiological agent of aspergillosis. Invasive aspergillosis is a major cause of death in leukaemic and organ transplant patients. The azoles are the largest and the most widely used class of antifungals. Antifungal drug resistance has been observed in many fungi. In many organisms, acquiring resistance to a drug can confer a biological fitness cost that is expressed for example as decreased growth rate or virulence. A total number of 21 A. fill11igatus clinical isolates were used in this project. Sixteen of these isolates were recovered serially from
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Venkateswarlu, Kanamarlapudi. "Azole antifungal drugs mode of action and resistance." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389558.

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Liu, Teresa T. "Transcriptional regulation of azole antifungal resistance in candida albicans." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-023-Liu-index.html.

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Thesis (M.S.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on July 31, 2008). Research advisor: P. David Rogers, Pharm.D., Ph.D. Document formatted into pages (xii, 172 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 98-115).
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Rodrigues, de Melo Nadja. "Fungal azole resistance and the role of cytochrome P450." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42593.

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The incidence of fungal infections and particularly infections caused by non- albicans Candida species has increased considerably in the past two decades. The azole antifungal drugs are central to the management of fungal infections and like the use of other antibiotics drug resistance has emerged. Factors associated with antifungal resistance were investigated including azole susceptibility, drug accumulation and membrane sterol composition. Intracellular drug accumulation in Candida strains and species was examined and a clear correlation to microbial sensitivity was not observed. Also the m
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Kamai, Yasuki. "Studies on azole resistance and virulence of Candida albicans, and novel antifungal agents." Kyoto University, 2004. http://hdl.handle.net/2433/145438.

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Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(農学)<br>乙第11557号<br>論農博第2544号<br>新制||農||901(附属図書館)<br>学位論文||H16||N3980(農学部図書室)<br>22817<br>UT51-2004-T201<br>(主査)教授 植田 和光, 教授 加藤 暢夫, 教授 植田 充美<br>学位規則第4条第2項該当
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Kumar, Neelam. "Mechanisms of TRAIL resistance." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052624/.

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Malignant pleural mesothelioma (MPM) is a devastating disease for which limited effective therapies are currently available. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and other death receptor (DR) agonists are pro-apoptotic agents that trigger the extrinsic apoptotic pathway selectively in cancer cells. Previous work has shown that supports that loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) augments sensitivity to recombinant TRAIL (rTRAIL) in MPM cells. This study shows that BAP1 is a candidate biomarker for rTRAIL sensitivity in cell l
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Books on the topic "Mechanisms of azole resistance"

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Brown, Robert, and Uta B�ger-Brown. Cytotoxic Drug Resistance Mechanisms. Humana Press, 1999. http://dx.doi.org/10.1385/1592596878.

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Targeted therapies: Mechanisms of resistance. Humana Press, 2011.

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Mullin, Christopher A., and Jeffrey G. Scott, eds. Molecular Mechanisms of Insecticide Resistance. American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0505.

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Bock, Gregory, and Jamie A. Goode, eds. Mechanisms of Drug Resistance in Epilepsy. John Wiley & Sons, Ltd, 2002. http://dx.doi.org/10.1002/0470846356.

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Bock, Gregory, and Jamie A. Goode, eds. Mechanisms of Drug Resistance in Epilepsy. John Wiley & Sons, Ltd, 2002. http://dx.doi.org/10.1002/0470846356.

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Slusarenko, A. J., R. S. S. Fraser, and L. C. van Loon, eds. Mechanisms of Resistance to Plant Diseases. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-3937-3.

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Sjut, Volkert, ed. Molecular Mechanisms of Resistance to Agrochemicals. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-662-03458-3.

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Fraser, R. S. S., ed. Mechanisms of Resistance to Plant Diseases. Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5145-7.

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A, Smith Mark. Mechanisms of metronidazole resistance in helicobacter pylori. UEL, 1995.

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International, Congress of Endocrinology (7th 1984 Québec Québec). Steroid hormone resistance: Mechanisms and clinical aspects. Plenum Press, 1986.

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Book chapters on the topic "Mechanisms of azole resistance"

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Seyedmousavi, Seyedmojtaba, and Paul E. Verweij. "Azole Resistance in Aspergillus fumigatus: Mechanisms, Route of Resistance Selection, and Clinical Implications." In Handbook of Antimicrobial Resistance. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-0667-3_22-1.

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Zavrel, Martin, Brooke D. Esquivel, and Theodore C. White. "The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport." In Handbook of Antimicrobial Resistance. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0667-3_29-1.

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Seyedmousavi, Seyedmojtaba, and Paul E. Verweij. "Azole Resistance in Aspergillus fumigatus: Mechanisms, Route of Resistance Selection, and Clinical Implications." In Handbook of Antimicrobial Resistance. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-0694-9_22.

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Zavrel, Martin, Brooke D. Esquivel, and Theodore C. White. "The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport." In Handbook of Antimicrobial Resistance. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-0694-9_29.

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Posteraro, Brunella, Antonietta Vella, Elena De Carolis, and Maurizio Sanguinetti. "Molecular Detection of Resistance to Azole Components." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6515-1_24.

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Reimann-Philipp, Ulrich. "Mechanisms of Resistance." In Plant Virology Protocols. Humana Press, 1998. http://dx.doi.org/10.1385/0-89603-385-6:521.

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Boehr, David D., Ian F. Moore, and Gerard D. Wright. "Aminoglycoside Resistance Mechanisms." In Frontiers in Antimicrobial Resistance. ASM Press, 2014. http://dx.doi.org/10.1128/9781555817572.ch7.

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Huang, Jeng-Sheng. "Mechanisms of resistance." In The Cyst Nematodes. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-015-9018-1_14.

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Mukhopadhyay, Rita, Jiaxin Li, Hiranmoy Bhattacharjee, and Barry P. Rosen. "Metalloid Resistance Mechanisms." In Resolving the Antibiotic Paradox. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4897-3_9.

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Lambach, Daniel, Markus Bayer, Felix S. Bethke, Matteo Dressler, and Véronique Dudouet. "Mechanisms." In Nonviolent Resistance and Democratic Consolidation. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39371-7_4.

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Conference papers on the topic "Mechanisms of azole resistance"

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"Molecular mechanisms of antibiotic resistance." In International Conference on Medicine, Public Health and Biological Sciences. CASRP Publishing Company, Ltd. Uk, 2016. http://dx.doi.org/10.18869/mphbs.2016.162.

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Broekgaarden, Colette. "Unraveling whitefly resistance mechanisms in cabbage." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.106048.

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Braoudaki, M., and A. C. Hilton. "Mechanisms of resistance in Salmonella enterica." In Fifth International Symposium on the Epidemiology and Control of Foodborn Pathogens in Pork. Iowa State University, Digital Press, 2003. http://dx.doi.org/10.31274/safepork-180809-551.

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Liu, Nannan. "Insecticide resistance: Impact, mechanisms, and research directions." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.95462.

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Katayama, Ryohei, Noriko Yanagitani, Sumie Koike, et al. "Abstract 3590: Resistance mechanisms to ALK inhibitors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3590.

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Li, Honghao, and Sherif El-Tawil. "Collapse Resistance Mechanisms in Steel Frame Buildings." In Structures Congress 2013. American Society of Civil Engineers, 2013. http://dx.doi.org/10.1061/9780784412848.001.

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Haynes, Kenneth F. "Mechanisms of insecticide resistance in the bed bug: Implications for resistance management." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.93662.

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Kawasaki, Masashi, Akihito Sawa, and Yoshnori Tokura. "Mechanisms of Resistance Switching Memory Effect in Oxides." In 2006 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2006. http://dx.doi.org/10.7567/ssdm.2006.c-5-1.

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Solanki, Hitendra Singh, Bin Fang, Eric A. Welsh, et al. "Abstract 3410: Adaptive resistance mechanisms to KRASG12Cspecific inhibitors." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3410.

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Uppaluri, Ravindra. "Abstract IA18: Interrogating anti-PD1 immunotherapy resistance mechanisms." In Abstracts: AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 29-30, 2019; Austin, TX. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.aacrahns19-ia18.

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Reports on the topic "Mechanisms of azole resistance"

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Schubert, David R. Mechanisms of Resistance to Neurotoxins. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada398170.

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Schubert, David R. Mechanisms of Resistance to Neurotoxins. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada384832.

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O'Mahony, Orla A. Differential Mechanisms of Androgen Resistance. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada467564.

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O'Mahony, Orla A. Differential Mechanisms of Androgen Resistance. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada482091.

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Gerhardt, Philipp. Mechanisms of Resistance in Microbial Spores. Defense Technical Information Center, 1986. http://dx.doi.org/10.21236/ada175595.

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Clarke, Robert. Molecular Mechanisms of Estrogen and Antiestrogen Resistance. Defense Technical Information Center, 2000. http://dx.doi.org/10.21236/ada395408.

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Clarke, Robert R. Molecular Mechanisms of Estrogen and Antiestrogen Resistance. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada418636.

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Clarke, Robert R. Molecular Mechanisms of Estrogen and Antiestrogen Resistance. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada403335.

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Smith, Lisa S., Vipin K. Rastogi, and Lalena Wallace. Adaptive Mechanisms Underlying Microbial Resistance to Disinfectants. Defense Technical Information Center, 2016. http://dx.doi.org/10.21236/ad1002922.

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Huang, Chung-Ying. Targeting Mechanisms of Resistance to Taxane-Based Chemotherapy. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada488813.

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