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Dissertations / Theses on the topic 'Mechanisms of persistence'

Author: Grafiati

Published: 4 June 2025

Last updated: 14 July 2025

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1

Nixon, Clare Paula. "The biology and mechanisms of persistence in baculoviruses." Thesis, Oxford Brookes University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397056.

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2

MARQUES, FABIO SEIXAS. "A PROCESS BASED ON MDA FOR SPECIALIZATION OF PERSISTENCE MECHANISMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=9236@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>Com as constantes mudanças nos requisitos funcionais e não- funcionais do domínio das aplicações, há uma grande necessidade dos softwares se adaptarem a essas mudanças. Devido a isso, o processo proposto neste trabalho tem o intuito de automatizar algumas partes do desenvolvimento de aplicações, minimizando o trabalho manual necessário para adaptar os sistemas de software às constantes necessidades de mudanças determinadas pela realidade do mundo dos negócios. A abordagem Model Driven Architecture (MDA), definida pela OMG, foi utiliza

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3

Moreira, Bruno Ricardo Jesus. "Fire persistence mechanisms in Mediterranean plants: ecological and evolutionary consequences." Doctoral thesis, Universidad de Alicante, 2012. http://hdl.handle.net/10045/27518.

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4

Guo, Rui. "Novel pathogenic mechanisms of porcine reproductive and respiratory syndrome virus: intercellular transmission and persistence." Diss., Kansas State University, 2018. http://hdl.handle.net/2097/38666.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Ying Fang<br>Porcine reproductive and respiratory syndrome virus (PRRSV) causes a tremendous economic loss in swine industry worldwide. The capabilities to evade host immune responses and to establish persistent infection are the two hallmark features of PRRSV infection. In this dissertation, the research was mainly focused on investigating the novel mechanisms underlying PRRSV transmission and persistence. In chapter 2, the research was focused on an alternative pathway of PRRSV intercellular transmission. Our data sho

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5

Emmerson, Louise M. "Persistence mechanisms of Erodiophyllum elderi, an arid land daisy with a patchy distribution /." Title page, abstract and contents only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phe54.pdf.

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6

Jaigirdar, Shafqat Ahrar. "Investigating the molecular mechanisms of CD4 T cell persistence at inflamed peripheral tissues." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8952/.

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CD4 T cells play an important role in the initiation and maintenance of inflammation in numerous inflammatory diseases. Rheumatoid arthritis (RA) is one such autoimmune inflammatory condition where inflammation of the joint occurs. CD4 T cells are one of the key cells in RA pathogenesis due to their ability to activate or influence other cells in the joint including B cells, macrophages and osteoclasts, which collectively lead to joint destruction. The recruitment and function of CD4 T cells at inflamed tissues has been studied extensively. However, the signals that regulate CD4 T cell accumul

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7

Löfmark, Sonja. "Incidence, emergence, persistence and mechanisms of antimicrobial resistance in clinical isolates and normal microbiota /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-127-2/.

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8

Cabatingan, Mark S. "Mechanisms of Establishment and Maintenance of RNA Virus Persistence in Primary Lymphocytes: a Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/125.

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RNA virus persistence in lymphocytes has been studied extensively in vitro, but the influence of lymphocyte homeostatic mechanisms and antiviral immunity on persistence has not been well studied in an in vivo system. It is demonstrated here that vesicular stomatitis virus (VSV), a negative-strand RNA virus, is maintained in B lymphocytes in vivo despite the existence of homeostatic mechanisms that drive the cells to proliferate under conditions of B cell deficiency and a strong antibody response to the virus. It is also shown that antiviral antibodies inhibit VSV reactivation from persistently

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9

Lee, Eunok. "Identifying cellular mechanisms contributing to HIV persistence in T-cell subsets during prolonged antiretroviral therapy." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24374.

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The number of people living with HIV has been increasing worldwide since the introduction of antiretroviral therapy (ART) as this treatment has decreased the number of deaths caused by acquired immunodeficiency disease syndrome (AIDS). However, ART is not curative as it suppresses HIV in the plasma to an undetectable level while HIV continues to persist in memory T-cells. This persistent virus inevitably resumes its replication when therapy is ceased; indicating a life-long adherence to treatment is required. To effectively target HIV persistence with a goal of achieving a cure, it will be imp

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10

Gibbs, Nichole. "The Impact of Personalization-Based Tailored Instructional Communications on College Student Persistence." ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/1062.

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The low graduation rate of degree-seeking students at public community colleges is an important crisis facing communities across the United States. College satisfaction and withdrawal cognitions in students have been identified as key factors in college persistence by researchers. However, a review of the literature revealed no study in which a college-persistence intervention based on the personalization principle theory or using tailored messages has been conducted. The purpose of this study was to test the effectiveness of a college-persistence intervention, based on the personalization pri

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11

Surita, Sharon C. "Emergence and Fate of Siloxanes in Waste Streams: Release Mechanisms, Partitioning and Persistence in Three Environmental Compartments." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1899.

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Siloxanes are widely used in personal care and industrial products due to their low surface tension, thermal stability, antimicrobial and hydrophobic properties, among other characteristics. Volatile methyl siloxanes (VMS) have been detected both in landfill gas and biogas from anaerobic digesters at wastewater treatment plants. As a result, they are released to gas phase during waste decomposition and wastewater treatment. During transformation processes of digester or landfill gas to energy, siloxanes are converted to silicon oxides, leaving abrasive deposits on engine components. These depo

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12

Baumgärtner, Wolfgang K. "Mechanisms of in vitro persistence of two canine paramyxoviruses and in vivo neuropathogenecity of canine parainfluenza virus /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487265555440015.

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13

Verdikt, Roxane. "Epigenetic and Transcriptional Mechanisms of Human Immunodeficiency Virus type 1 Persistence in T-lymphoid and Myeloid Reservoirs." Doctoral thesis, Universite Libre de Bruxelles, 2019. https://dipot.ulb.ac.be/dspace/bitstream/2013/287450/3/PhD.pdf.

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HIV-1 infections can be treated but not cured by the current antiretroviral therapy regimens. One of the major barriers to HIV-1 eradication is the persistence of the virus in treated HIV+ individuals under the form of reservoirs. A continuum of molecular mechanisms, at the epigenetic, transcriptional and post-transcriptional levels maintains HIV-1 gene expression silent in its reservoirs. A better understanding of HIV-1 molecular mechanisms of persistence thus allows to devise novel therapeutic approaches to eradicate the virus. In this context, our thesis aimed at characterizing the molecula

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14

Rycroft, Julian Anthony. "The roles of bacterial virulence mechanisms, including intracellular persistence, in determining outcome of infection by invasive nontyphoidal Salmonella." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/56992.

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While typhoidal serovars of Salmonella are human-restricted and cause invasive disease, nontyphoidal serovars infect a range of mammalian hosts, causing enterocolitis or systemically disseminated “invasive” disease. Invasive nontyphoidal salmonellosis is a major neglected tropical disease. In sub-Saharan Africa emergent clades of genetically distinct invasive strains are amongst the most common cause of bacteraemia. Prevalence, mortality and recurrence are all high. There is growing evidence that recurrence is attributable to resuscitation of non-growing intracellular persister Salmonella, the

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15

Roach, Kylie A. "Mechanisms for Growth and Persistence of Francisella tularensisWithin Macrophages: a Role for iglC." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1199283300.

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16

Martello, Marina <1983&gt. "The search for Multiple Myeloma Stem cells: molecular characterization and self-renewal mechanisms involved in the disease persistence." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6199/1/Martello_Marina_Tesi.pdf.

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The existence of Multiple Myeloma Stem cells (MMSCs)is supposed to be one of the major causes of MM drug-resistance. However, very little is known about the molecular characteristics of MMSCs, even if some studies suggested that these cells resembles the memory B cells. In order to molecularly characterize MMSCs, we isolated the 138+138- population. For each cell fraction we performed a VDJ rearrangement analysis. The complete set of aberrations were performed by SNP Array 6.0 and HG-U133 Plus 2.0 microarray analyses (Affymetrix). The VDJ rearrangement analyses confirmed the clonal relat

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17

Martello, Marina <1983&gt. "The search for Multiple Myeloma Stem cells: molecular characterization and self-renewal mechanisms involved in the disease persistence." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6199/.

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The existence of Multiple Myeloma Stem cells (MMSCs)is supposed to be one of the major causes of MM drug-resistance. However, very little is known about the molecular characteristics of MMSCs, even if some studies suggested that these cells resembles the memory B cells. In order to molecularly characterize MMSCs, we isolated the 138+138- population. For each cell fraction we performed a VDJ rearrangement analysis. The complete set of aberrations were performed by SNP Array 6.0 and HG-U133 Plus 2.0 microarray analyses (Affymetrix). The VDJ rearrangement analyses confirmed the clonal relat

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18

Du, Plooy Schalk Jacobus. "Ecophysiology and nutrient uptake mechanisms facilitating the prolonged bloom persistence by Cyanothece sp. in Lake St Lucia, South Africa." Thesis, Nelson Mandela Metropolitan University, 2017. http://hdl.handle.net/10948/7344.

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Cyanobacterial blooms are becoming more frequent worldwide, with possible negative effects on human health. The effects of climate change and eutrophication have been associated with persistent cyanobacterial blooms becoming more frequent. Altered water characteristics, salinity in particular, influence ecosystem dynamics that may lead to conditions conducive to cyanobacterial blooms. The occurrence of an 18-month long Cyanothece sp. bloom (the longest for any cyanobacterium recorded so far worldwide and the first of the genus) from June 2009 to December 2010 in Africa’s largest estuarine lake

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19

Thompson, Glen Andrew. "Mechanisms of invasion and persistence of the invasive kelp Undaria pinnatifida (Harvey) Suringar within intertidal areas of southern New Zealand." Thesis, University of Canterbury. Zoology, 2004. http://hdl.handle.net/10092/6875.

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Very few studies have examined the mechanisms of local establishment and persistence of invasive marine species, especially invasive seaweeds. Undaria pinnatifida, an invasive kelp from Japan, Korea and China was first discovered in New Zealand in 1987. Although U. pinnatifida's spread has been rapid, particularly along the east coast of southern New Zealand very little is known about how this species establishes and persists within invaded areas. This study is unique in that it determines some of the characteristics and mechanisms that enable Undaria pinnatifida to invade and persist in inter

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20

Vilhena, Catarino Brito David [Verfasser], and Ana [Akademischer Betreuer] Oliveira. "Molecular Mechanisms of Memory Formation and Persistence in the Adult and Aged Brain / David Vilhena Catarino Brito ; Betreuer: Ana Oliveira." Heidelberg : Universitätsbibliothek Heidelberg, 2021. http://d-nb.info/1229092684/34.

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21

Šemanjski, Maja [Verfasser], and Boris [Akademischer Betreuer] Maček. "Molecular mechanisms of HipA-mediated bacterial persistence in E. coli investigated by mass spectrometry-based proteomics / Maja Šemanjski ; Betreuer: Boris Maček." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1202774156/34.

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22

Cebulla, Colleen M. "Human Cytomegalovirus induces adhesion molecules Sialyl LewisX and LewisX and disrupts constitutive MHC Class II expression : novel mechanisms of dissemination and persistence /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488196781735557.

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23

Amelkina, Olga [Verfasser], Katarina [Akademischer Betreuer] Jewgenow, Monika [Akademischer Betreuer] Reißmann, and Almuth [Akademischer Betreuer] Einspanier. "Corpus luteum of the domestic cat and lynx : structure, regulation and potential mechanisms of its persistence / Olga Amelkina. Gutachter: Katarina Jewgenow ; Monika Reißmann ; Almuth Einspanier." Berlin : Lebenswissenschaftliche Fakultät, 2016. http://d-nb.info/1090965680/34.

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24

Nait, Eldjoudi Amina. "Unraveling escape and metastasis mechanisms in triple negative breast cancer following chemotherapy treatment." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS119.

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Le cancer du sein triple négatif (TNBC) est un sous-type particulièrement agressif du cancer du sein, traité principalement par chimiothérapie. Cependant, environ 50% des patients connaissent une rechute avec métastases dans les 3 à 5 ans suivant le traitement. Afin de mieux comprendre l'évasion post-chimiothérapie et la formation de métastases des cellules cancéreuses TNBC, nous avons établi des modèles de cellules TNBC en traitant les cellules SUM159-PT et MDA-MB-231 avec de l'épirubicine, du cyclophosphamide et du paclitaxel, simulant des protocoles cliniques. Nous nous sommes initialement

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25

Baumann, Lisa Annie [Verfasser], and Thomas [Akademischer Betreuer] Braunbeck. "Zebrafish (Danio rerio) as a model to study developmental effects of endocrine disruption: molecular mechanisms, as well as persistence and reversibility of effects / Lisa Annie Baumann ; Betreuer: Thomas Braunbeck." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/117714820X/34.

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26

Baumann, Lisa [Verfasser], and Thomas [Akademischer Betreuer] Braunbeck. "Zebrafish (Danio rerio) as a model to study developmental effects of endocrine disruption: molecular mechanisms, as well as persistence and reversibility of effects / Lisa Annie Baumann ; Betreuer: Thomas Braunbeck." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-145124.

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27

Webb, Matthew S. "Evaluating tool based automated malware analysis through persistence mechanism detection." Thesis, Kansas State University, 2018. http://hdl.handle.net/2097/38783.

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Master of Science<br>Department of Computer Science<br>Eugene Vasserman<br>Since 2014 there have been over 120 million new malicious programs registered every year. Due to the amount of new malware appearing every year, analysts have automated large sections of the malware reverse engineering process. Many automated analysis systems are created by re-implementing analysis techniques rather than automating existing tools that utilize the same techniques. New implementations take longer to create and do not have the same proven quality as a tool that evolved alongside malware for many years. Th

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28

Inglis, Julia Jane. "Characterisation of novel nociceptive mechanisms during persistent inflammation." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413580.

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29

Mitchell, Peter James. "Inappropriate Regulation as a Mechanism for Persistence of Helicobacter Pylori Infection." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486573.

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30

Christiansen, Anne M. "Neural mechanisms mediating persistent stress relief by comfort food." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275921773.

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31

Harish, Omri. "Network mechanisms of working memory : from persistent dynamics to chaos." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T073/document.

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Une des capacités cérébrales les plus fondamentales, qui est essentiel pour tous les fonctions cognitifs de haut niveau, est de garder des informations pertinentes de tâche pendant les périodes courtes de temps; on connaît cette capacité comme la mémoire de travail (WM). Dans des décennies récentes, accumule là l'évidence d'activité pertinente de tâche dans le cortex préfrontal (PFC) de primates pendant les périodes de "delay" de tâches de "delay-response", impliquant ainsi que PFC peut maintenir des informations sensorielles et ainsi la fonction comme un module de WM. Pour la récupération d'i

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32

Hoffmann, Linn [Verfasser]. "Adaptation mechanisms of Antarctic phytoplankton to persistent iron limitation / Linn Hoffmann." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1019952377/34.

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33

Aggarwal, Anjna. "Mediators and mechanisms of persistent pulmonary neutrophilia in acute lung injury." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289880.

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34

Glaros, Trevor Griffiths. "Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/73001.

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Low dose endotoxemia is caused by several health conditions including smoking, alcohol abuse, high fat diets, and aging. Several studies have correlated low dose endotoxemia with increased risks of atherosclerosis, diabetes, and Parkinson's disease. Unlike high doses of endotoxin which induce a strong but transient induction of pro-inflammatory mediators, low doses of endotoxin result in a mild but chronic induction of pro-inflammatory genes. The central hypothesis of our study was that if low doses of endotoxin are capable of inducing mild prolonged inflammation, then a unique signaling ci

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35

Goormaghtigh, Frederic. "New insights into the persistence phenomenon." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/235567.

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Together with the current antibiotic resistance crisis, bacterial persistence appears to play an increasingly important role in the frequent failure of antibiotic treatments. Persister cells are rare bacteria that transiently become drug tolerant, allowing them to survive lethal concentrations of bactericidal antibiotics. Upon antibiotic removal, persister cells are able to resume growth and give rise to a new bacterial population as sensitive to the antibiotic as the original population. Interest in persister cells seriously increased in the past few years as these phenotypic variants were sh

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36

Landers, Evan. "CHARACTERIZATION OF THE CHLAMYDIAL PARTNER SWITCHING MECHANISM USING IN VITRO, IN VIVO, AND IN SILICO APPROACHES." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2326.

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Chlamydia trachomatis is a Gram-negative, obligate intracellular pathogen that is the causative agent of sexually transmitted infections and the ocular disease trachoma. Chlamydia trachomatis undergoes a biphasic developmental cycle differentiating between the infectious elementary body (EB) and the replicative reticulate body (RB). Under certain stress conditions, C. trachomatis can stall its developmental cycle and enter an aberrant state termed persistence. While in a persistent state, C. trachomatis is refractory toward antibiotics, can evade the host immune response, and becomes undetecta

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37

Hummel, Kimberly Brown. "Alteration of the measles virus glycoproteins as a mechanism to reduce cell fusion during persistence." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25597.

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38

Yin, Han Ph D. Massachusetts Institute of Technology. "Mechanism and Applications of large and persistent photoconductivity in cadmium sulfide." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127735.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2020<br>Cataloged from PDF of thesis.<br>Includes bibliographical references (pages 119-130).<br>Photoconductivity is the phenomenon where electrical conductivity changes as a result of photoexcitation of new charge carriers. In some semiconductors, photoconductivity is accompanied with enormous conductivity change and long decay time after photoexcitation is ceased. This effect is called large and persistent photoconductivity (LPPC). LPPC is due to the trapping of photo-generated minority carriers at

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39

Faris, Mary N. "Characterization of the mechanism of persistent I-A expression by macrophages /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688507502621.

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40

Seich, al Basatena Nafisa-Katrin. "HLA-mediated control and CD8+ T cell response mechanisms in persistent viral infections." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/10753.

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Background: There are many viruses that result in persistent infections affecting millions of people worldwide. Although our immune system deploys different strategies to eliminate them, many times they prove unsuccessful and call for a better understanding of the host-virus interplay. One important weapon of the immune system is CD8+ T cells which identify infected cells and limit the spread of infection using different effector mechanisms. Aim: The aim of this study is two-fold; the investigation of 1) the impact of immunogenetic factors such as HLA class I molecules and Killer cell immunogl

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41

Larimer, Phillip. "Local Circuit and Intrinsic Mechanisms of Persistent Activity in the Dentate Hilus of the Hippocampus." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1246573016.

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42

Saunier, Rebori Bernadette. "The neural mechanisms of persistent inhibition in the DNLL of the gerbil (Meriones unguiculatus)." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-83172.

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Saunier, Rebori Bernadette T. "The neural mechanisms of persistent inhibition in the DNLL of the gerbil (Meriones unguiculatus)." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8317/.

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BLOIS, SYLVAIN SERGE DANIEL. "A Genetic Barcode Approach to Elucidate the Mechanisms of Polyomavirus Persistent Infection in vivo." Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/270446.

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Human polyomaviruses are highly prevalent in the general population and establish a long-term asymptomatic infection in healthy individuals. However, a change in the immune status or hormone levels can lead to life-threatening diseases, including tumors. These diseases typically require reactivation from a persistent infection. Currently, a long-standing question in the field of virology is understanding how polyomaviruses undergo a life-long persistent infection in their natural host. Indeed, despite the high seroprevalence of polyomaviruses, little is understood about the mechanisms allowing

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45

Nickle, David C. "Molecular evolutionary methods to design an effective HIV vaccine and to determine the mechanism of HIV persistence /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/11502.

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Kumari, Ashu [Verfasser], and Andreas [Akademischer Betreuer] Burchert. "Elucidation of mechanism of disease resistance and persistence in chronic myeloid leukemia / Ashu Kumari. Betreuer: Andreas Burchert." Marburg : Philipps-Universität Marburg, 2011. http://d-nb.info/1014851823/34.

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47

Tong, Mingjie. "Mechanisms Underlying Subthreshold and Suprathreshold Responses in Dorsal Cochlear Nucleus Cartwheel Cells." University of Toledo / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1133806721.

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48

Evans, Katherine J. "A quantitative analysis of the physical mechanisms governing the life cycles of persistent flow anomalies." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/26013.

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49

Read, Amanda. "Study of molecular mechanisms underlying persistent Bartonella infections : interactions with erythrocytes and circumnavigation of host immunity." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417971.

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Revill, Ann. "Role of Synaptic and Non-Synaptic Mechanisms Underlying Motor Neuron Control." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202994.

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While motor neuron activity has been studied for many decades, the relative contribution of synaptic and non-synaptic mechanisms underlying this activity during natural behaviors is not well understood. Thus, the goal of this dissertation was to further understand the role of non-synaptic properties of motor neurons during voluntary activity. In particular, I considered three non-synaptic properties: persistent inward currents (PICs) that boost synaptic inputs, spike-threshold accommodation that affects recruitment threshold as excitation rates of rise slow, and spike-frequency adaptation that

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