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Relevant bibliographies by topics / Mechanotransduction / Dissertations / Theses

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Dissertations / Theses on the topic 'Mechanotransduction'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Huang, Wei. "Polycystin-1 and Bone Mechanotransduction." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10279.

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Bone mechanotransduction is a fundamental process underlying the remarkable ability of bones to perceive surrounding physical cues and adapt their mass, structure and overall strength to their mechanical environment. Therefore, it is central to many aspects of bone biology and disease. The key to a mechanistic understanding of this process lies in better knowledge of critical signaling molecules that relay the mechanical information inside bone cells. In this thesis, we investigate the role of polycystin-1 (PC1), a proposed fluid flow sensor in kidney epithelial cells, in transducing mechanica

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2

Chronopoulos, Antonios. "Mechanotransduction in health and disease." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/56622.

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Physical forces regulate cellular behaviour and function during all stages of life. Mechanotransduction, the process by which cells convert mechanical stimuli into biochemical signalling events is central to a number of physiological and pathological processes. The first part of this work focuses on the effect of retinoid therapy on the mechanobiology of pancreatic cancer. Pancreatic cancer is characterised by a persistent activation of stromal fibroblasts, known as pancreatic stellate cells (PSCs), which can perturb the biomechanical homeostasis of the tumour microenvironment to favour tumour

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3

Pucker, Andrew David. "Mechanotransduction in the Ciliary Muscle." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460647729.

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4

Malone, Amanda Michelle Dolphin. "Mechanotransduction mechanisms in bone cells /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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5

Kuck, Jan L. "Mechanotransduction in red blood cells." Thesis, Griffith University, 2023. http://hdl.handle.net/10072/421118.

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Red blood cells (RBC), the oxygen-carriers within blood, eject their nuclei and other organelles to optimise cellular mechanics for gas exchange in capillary networks. Lack of organelles, however, strictly limits circulatory longevity of these cells, due to the inability to repair damaged cellular components. Given the turnover of RBC, the cell population within blood is inherently heterogenous, comprising RBC across the whole spectrum of in vivo age. Moreover, surrender of translational capacity restricts cellular signalling within RBC to modifications of existing proteins and/or flux of ions

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6

Bays, Jennifer McQuown. "Mechanisms of E-cadherin mechanotransduction." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5711.

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Cells experience force throughout their lifetimes. Cells sense force via adhesion receptors, such as the cadherins, which anchor cells to neighboring cells, and integrins, which tether cells to the underlying matrix. Both adhesion receptors respond to force by activating signaling pathways inside the cell. These pathways trigger growth of adhesion complexes and reinforcement of the cytoskeleton in order to resist the force. These activities are energetically costly. Thus, mechanisms are needed to couple force transmission and energy production. In this thesis, I demonstrated force on cadherins

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7

Bouclet, Adrien. "Evolutionary implication of mechanotransduction in development." Phd thesis, Université René Descartes - Paris V, 2014. http://tel.archives-ouvertes.fr/tel-01071238.

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In this thesis, I first focused on the testing of the hypothesis of the mechanotransductive activation of the apical accumulation of Myosin-II (Myo-II) that leads to Drosophila embryos mesoderm invagination, in response to the active cell apex pulsations preceding gastrulation in the mesoderm. This hypothesis was proposed on the basis of previous experiments realized in my host lab, having consisted in the rescue of mesoderm invagination in pulsation and invagination defective mutants, in response to a simple mechanical indent of the mesoderm. Here I demonstrated quantitatively the plausibilit

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8

Aragona, Mariaceleste. "Role of YAP/TAZ in Mechanotransduction." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422159.

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Cells perceive their microenvironment not only through soluble signals but also in term of physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behavior, including growth, differentiation and cancer malignant progression; but how rigidity mechanosensing is ultimately linked to activity of nuclear transcription factors remains poorly understood. Here we report the identification of the Yorkie-homologues YAP and TAZ as nuclear

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9

Dutour, Provenzano Gaëlle. "Role of intermediate filaments in mechanotransduction." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS364.

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Les cellules s'adaptent en permanence à leur microenvironnement. En particulier, elles modifient leur morphologie, leur croissance, leur division et leur motilité en fonction des propriétés biochimiques et physiques de la matrice extracellulaire (MEC). Elles sont équipées de structures adhésives appelées plaques d’adhérences, permettant aux cellules d'interagir avec les protéines de la MEC via les protéines transmembranaires appelées intégrines et de détecter la nature et la rigidité de la MEC. Le signal est transduit par les protéines des plaques d’adhérences et résulte par exemple en une mod

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10

Huesa, Carmen. "Mechanotransduction in cells of the osteoblast lineage." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25468.

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11

Pardo, Pastor Carlos 1989. "Piezo ion channels in cancer cell mechanotransduction." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664209.

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The mechanical dependence of transformation and metastasis is an emerging field, but the role of mechanosensitive channels has been largely omitted. This thesis focuses on the roles played by the mechanosensitive ion channels Piezo1 and Piezo2 in the transduction of mechanical stimuli (confinement, adhesion, substrate rigidity, adhesive ligand concentration) by cancer cells. In a first chapter, we show that confinement triggers Piezo1-mediated calcium entry. This activates phosphodiesterase 1, reducing cAMP levels and, consequently, PKARac1 activity, relieving Myosin II from its inhibition.

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12

Al-Rekabi, Zeinab. "Investigating Mechanotransduction and Mechanosensitivity in Mammalian Cells." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30256.

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Living organisms are made up of a multitude of individual cells that are surrounded by biomolecules and fluids. It is well known that cells are highly regulated by biochemical signals; however it is now becoming clear that cells are also influenced by the mechanical forces and mechanical properties of the local microenvironment. Extracellular forces causing cellular deformation can originate from many sources, such as fluid shear stresses arising from interstitial or blood flow, mechanical stretching during breathing or compression during muscle contraction. Cells are able to sense variations

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13

Lammerding, Jan 1974. "Quantitative analysis of subcellular biomechanics and mechanotransduction." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/18039.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.<br>Includes bibliographical references.<br>Biological cells such as endothelial or muscle cells respond to mechanical stimulation with activation of specific intracellular and extracellular signaling pathways and cytoskeletal remodeling, a process termed mechanotransduction. Intracellular mechanosensors are thought to be activated by conformational changes induced by local cellular deformations. Since these mechanosensors have been speculated to be located in several cellular domains including the ce

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14

Pitts-Yushchenko, Svetlana. "Mechanism of mechanotransduction in the Pacinian corpuscle." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/15429.

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Touch perception is important in most living organisms and extremely sensitive detection systems have evolved to meet this need. Pacinian corpuscles (PCs) are primary mechanoreceptors. In the human, they are found in the skin (where they act as touch receptors), in the joints, in muscles and in many organs (where they act as motion sensors). The purpose of the work described in this thesis is to investigate how the performance of the PC is achieved, with reference to structure, mechanical properties and possible transduction mechanisms. PCs were obtained from the equine hoof and their distribu

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15

Cappelli, Holly. "TRPV4 Mechanotransduction in Vascular Growth and Integrity." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1487764322127302.

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16

Lee, Herng-Sheng. "Integrin-mediated mechanotransduction in human articular chondrocytes." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23083.

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Mechanical forces influence chondrocyte metabolism and function. It has been shown that 0.33 Hz cyclical mechanical stimulation results in membrane hyperpolarization of normal human articular chondrocytes by activation of Ca<sup>2+</sup> -dependent K<sup>+</sup> (SK) channels. Using pharmacological inhibitors of intracellular signalling molecules, stretch-activated ion channels (SAC) and specific antibodies against integrins, integrin-associated protein, cytokines and cytokine receptors the data show that membrane hyperpolarization is the result of mechanically-induced secretion of IL-4. Secre

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17

Miller, Gregory J. "Mechanoregulation and mechanotransduction in skeletal tissue differentiation." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11147.

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Thesis (Ph.D.)--Boston University<br>Mechanical factors play a critical role in the development, maintenance and repair of skeletal tissues. Mechanical stimulation can alter the course of healing by directing the differentiation of mesenchymal progenitor cells into the cells that form the various skeletal tissues, and can enhance or impair the repair of orthopaedic injuries. Several mechanoregulatory hypotheses describing the relationships between mechanical stimuli and skeletal tissue differentiation have been proposed; however, these hypotheses have not been fully tested, nor have the underl

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18

ULLOA, SEVERINO LUISA. "Mechanobiology and mechanotransduction in propathological cellular system." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2919813.

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Cellule e tessuti rispondono alle force ambientali tramutandole in segnali biochimici. Questa proprietà cellulare ha indotto un largo interesse nell'area biochimica a studiare la possibilità di usare le proprietà meccaniche come un marker per la diagnosi precoce di malattie e per controllare il destino cellulare attraverso l'utilizzo di nuovi materiali prostetici. In questa tesi io ha mostrato che l'AFM può essere un eccellente strumento per valutare le proprietà meccaniche di differenti sistemi cellulari. In particolare io ho studiato la biomeccanica nella calcificazione della valvola aortica

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19

Shin, Jung-Bum. "Identification of genes involved in sensory neuron mechanotransduction." [S.l. : s.n.], 2002. http://www.diss.fu-berlin.de/2003/68/index.html.

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20

Jokl, Elliot. "Mechanotransduction at the Z-disc of skeletal muscle." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19324/.

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The importance of the transglutaminase-like protein kyphoscoliosis peptidase (KY) in skeletal muscle was discovered in a KY-deficient mouse model of hereditary kyphoscoliosis (ky/ky). The ky/ky pathology primarily affects muscles experiencing high tension, e.g., the soleus, which undergoes regeneration and shows persistent hallmarks of structural damage, including the aberrant localisation of the z-disc crosslinker Filamin C (FLNC) – a known KY interaction partner. However, muscles are globally smaller in size, and fast-twitch muscles (e.g., the extensor digitorum longus or EDL) show an inabil

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21

Karcher, Hélène. "The mechanics of mechanotransduction : analyses of cell perturbation." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/38239.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references.<br>Cells sense mechanical stimuli and respond by changing their phenotype, e.g. shape, gene expression, motility. This process, termed mechanotransduction, was investigated using computational and theoretical approaches, as well as comparisons with experiments. As a first step, a three-dimensional viscoelastic finite element model was developed to simulate cell micromanipulation by magnetocytometry. The model provided a robust tool for analysis of detailed stra

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22

McVittie, Anna K. (Anna Kathleen) 1977. "Pathways for mechanotransduction in pressurized airway epithelial cells." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/89315.

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23

Drew, Liam John. "Mechanisms of mechanotransduction by dorsal root ganglia neurons." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446740/.

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The molecular mechanisms that mediate mammalian sensory mechanotransduction are poorly understood. Detection of mechanical events by sensory neurons of the dorsal root ganglia (DRG) is the primary event in the senses of touch, pressure-induced pain and proprioception. Recent work has demonstrated that the somatic membrane of cultured DRG neurons is a suitable system for studying physical transduction. In this thesis the responses of cultured DRG neurons to focal mechanical stimulation were investigated. It was shown that mechanical stimulation activated non-selective cation channels in these c

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24

McNamara, Laura Elizabeth. "Molecular and cellular analysis of topography-induced mechanotransduction." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2207/.

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Edited Abstract: Mechanotransduction is the process by which cells convert mechanical stimuli into an adaptive gene- and protein-level response, via signalling cascades or direct physical effects of the cytoskeleton on the nucleus, and appropriate mechanosignalling is crucial for tissue development and function. Most techniques currently used to study cellular mechanoresponses are relatively damaging to the cells. In contrast, topographically structured substrates, such as microgrooves, have great potential for use as non-invasive mechanostimuli. In this study, quartz microgrooved substrata (2

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25

Dahl, Anna Caroline E. "Membrane protein mechanotransduction : computational studies and analytics development." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:67798647-8ed5-46e0-bde9-c71235fe70ba.

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Membrane protein mechanotransduction is the altered function of an integral membrane protein in response to mechanical force. Such mechanosensors are found in all kingdoms of life, and increasing numbers of membrane proteins have been found to exhibit mechanosensitivity. How they mechanotransduce is an active research area and the topic of this thesis. The methodology employed is classical molecular dynamics (MD) simulations. MD systems are complex, and two programs were developed to reduce this apparent complexity in terms of both visual abstraction and statistical analysis. Bendix detects an

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26

Heayn, Michelle Diane. "The Role of Caveolae in PECAM-1 Mechanotransduction." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/263778.

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Physiology<br>Ph.D.<br>Altered fluid flow, which is found in branches and curvatures of arteries, results in abnormal forces on the endothelial cells (EC). These forces have been shown to alter EC gene expression and phenotype and to activate several cellular structures including G-proteins, ion channels, adhesion molecules, and caveolae. Recently, PECAM-1 has been implicated as the primary sensor of hemodynamic forces in EC. Shear stress rapidly induces tyrosine phosphorylation of PECAM-1 and the recruitment of SHP-2. These events appear to contribute to shear-activation of ERK1/2. Additional

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27

FARRIS, FRANCESCO. "AMYLOID FIBRILS INDUCE GLYCOCALYX MEDIATED MECHANOTRANSDUCTION IN MELANOMA." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/946381.

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PMEL is an amyloidogenic protein found overexpressed in melanoma compared to healthy skin. PMEL expression correlates with unfavorable prognosis, but the mechanism beyond the adverse disease outcome is still unknown. Recently, our lab established a link between the presence of PMEL amyloid fibrils in the metastatic melanoma secretome and YAP activation, driving cancer proliferation and drug resistance. In this study, we show that PMEL amyloid fibrils, secreted by cancer cells, are component of the extracellular matrix and modify its stiffness thus activating mechanosignalling. We highlight

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28

Schwartz, Christine. "Muscle LIM protein and Nesprin-1 in Mechanotransduction." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066374/document.

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J’ai étudié trois protéines qui participent à deux vois différentes de méchano-transduction qui est la conversion des stimuli physiques en un signal biochimique.Dans une culture cellulaire en 2D, lorsque les cardiomyocytes sont étirés, MLP est transloqué vers le noyau. Sans translocation, les cellules ne parviennent pas à répondre à la stimulation. Les patients porteurs de mutations dans MLP développent une cardiomyopathie comme les souris MLP knock-out (MLP-/-). Mon objectif a été d’élucider le rôle de MLP dans ces cardiomyopathies en surexprimant des mutations de MLP dans les cardiomyocytes

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29

Schwartz, Christine. "Muscle LIM protein and Nesprin-1 in Mechanotransduction." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066374.pdf.

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J’ai étudié trois protéines qui participent à deux vois différentes de méchano-transduction qui est la conversion des stimuli physiques en un signal biochimique.Dans une culture cellulaire en 2D, lorsque les cardiomyocytes sont étirés, MLP est transloqué vers le noyau. Sans translocation, les cellules ne parviennent pas à répondre à la stimulation. Les patients porteurs de mutations dans MLP développent une cardiomyopathie comme les souris MLP knock-out (MLP-/-). Mon objectif a été d’élucider le rôle de MLP dans ces cardiomyopathies en surexprimant des mutations de MLP dans les cardiomyocytes

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30

Chowdhury, Tina Taneer. "Role of nitric oxide and PGEâ‚‚ in chondrocyte mechanotransduction." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246308.

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31

Liao, Pinhu. "Mechanotransduction in alveolar epithelial cells subjected to mechanical strain." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479153.

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32

Liu, Jie. "Mechanotransduction in Endothelial Cells:Cell Growth, Angiogenesis and Wound Healing." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1274392778.

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33

Balasubramanian, Lavanya. "Integrin Mediated Mechanotransduction in Renal Vascular Smooth Muscle Cells." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002227.

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34

Summerour, Sonya R. "Static equibiaxial stretch mediated mechanotransduction in adult cardiac fibroblasts /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9952652.

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35

Vanderploeg, Eric James. "Mechanotransduction in Engineered Cartilaginous Tissues: In Vitro Oscillatory Tensile Loading." Diss., Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-05192006-110158/.

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Thesis (Ph. D.)--Mechanical Engineering, Georgia Institute of Technology, 2007.<br>Radhakrishna, Harish, Committee Member ; LaPlaca, Michelle, Committee Member ; Nerem, Robert, Committee Member ; Garcia, Andres, Committee Member ; Levenston, Marc, Committee Chair.

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Lian, Ian Yu-Zen. "The roles of E-Tmod in mechanotransduction and cardiac myofibrillogenesis." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3249659.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed March 23, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 123-134).

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37

Schwartz, Christine [Verfasser]. "Muscle LIM Protein and Nesprin-1 in Mechanotransduction / Christine Schwartz." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/112815062X/34.

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38

Fitzgerald, Jonathan Basil. "Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33869.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.<br>Includes bibliographical references (p. 152-167).<br>Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a transient hydrostatic pressure buildup and fluid exudation from the compacted matrix until relaxation leads to a new equilibrium compressed state. Dynamic co

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Rabodzey, Aleksandr. "Flow-induced mechanotransduction in cell-cell junctions of endothelial cells." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/41586.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2006.<br>Includes bibliographical references (leaves 86-92).<br>Endothelial cells show an unexpected behavior shortly after the onset of laminar flow: their crawling speed decreases ~40% within the first 30 min, but only in a confluent monolayer of endothelial cells, not in subconfluent cultures, where cell-cell interactions are limited. This led us to study early shear effects on cell-cell adherens junctions. We found a 30±6% increase in the number of VE-cadherin molecules in the junctions. The strength o

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Kojić, Nikola 1978. "Mechanotransduction via airway epithelial cells : the effect of compressive stress." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40870.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2007.<br>"June 2007."<br>Includes bibliographical references (leaves 153-157).<br>A classic finding in asthma is a change in the structural organization of the airway epithelium. This complex process known as airway remodeling is not fully understood, and we believe that the forces accompanying airway constriction activate the epithelium and contribute to airway remodeling. To better understand this mechanotransduction mechanism we used an in vitro system of cultured normal human bronchial epithelial cells that could simu

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Jonas, Maxine. "Fluorescence laser tracking microrheology for quantitative studies of cytoskeletal mechanotransduction." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39911.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references (p. 111-127).<br>To shed light on the cell's response to its mechanical environment, we examined cell rheology at the single cell level and quantified it with nanometer spatial and microsecond temporal resolutions over a five-decade frequency range (- 0.5 Hz to 50 kHz). To this end, we developed and optimized an instrument for fast fluorescence laser tracking microrheology (FLTM). This novel method aims at experimentally deriving cellular viscoelastic properties

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Mahajan, Kalpesh D. "Development of Nanodevices for Bio-detection, Separation, Therapy, and Mechanotransduction." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376446892.

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43

Servin, Vences Martha Rocio [Verfasser]. "Ion-channel mediated mechanotransduction in chondrocytes / Martha Rocio Servin Vences." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1154766608/34.

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Childs, Peter Geoffrey. "Cellular mechanotransduction : development of a nanovibrational bioreactor for cellular stimulation." Thesis, University of the West of Scotland, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.739388.

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Saini, Navpreet S. "Cell Type and Substrate Dependence of Fibronectin Properties and Mechanotransduction." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5806.

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Fibronectin is an important protein that is able to bind to other fibronectin molecules and to cell surface receptors. In doing so, the interactions fibronectin can perform is important for the processes of cell migration and tissue formation. Understanding the properties of fibronectin and fibril assembly is useful for areas such as wound healing, where fibronectin molecules are assembled to protect the tissue and to perform other tasks. Because of these reasons, it is important to understand how fibronectin is assembled and how its properties affect the fibril assembly, which in return affec

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46

Fulzele, Keertik S. "ROLE OF ACTIN CYTOSKELETON FILAMENTS IN MECHANOTRANSDUCTION OF CYCLIC HYDROSTATIC PRESSURE." MSSTATE, 2004. http://sun.library.msstate.edu/ETD-db/theses/available/etd-07122004-171347/.

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This research examines the role of actin cytoskeleton filaments in chondroinduction by cyclic hydrostatic pressurization. A chondroinductive hydrostatic pressurization system was developed and characterized. A pressure of 5 MPa at 1 Hz frequency, applied for 7200 cycles (4 hours intermittent) per day, induced chondrogenic differentiation in C3H10T1/2 cells while 1800 cycles (1 hour intermittent) did not induce chondrogenesis. Quantitative analysis of chondrogenesis was determined as sulfated glycosaminoglycan synthesis and rate of collagen synthesis while qualitative analysis was obtained as A

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Roberts, Susan Read. "Mechanotransduction pathways associated with intracellular calcium in chondrocytes within 3D constructs." Thesis, Queen Mary, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270626.

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Polacheck, William J. (William Joseph). "Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85531.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.<br>"September 2013." Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 93-106).<br>Breast cancer incidence in the United States is I in 8, and over 90% of breast cancer related deaths are due to metastases, secondary tumors at a site distant from the primary tumor. Metastasis formation requires carcinoma cells to navigate through the tumor microenvironment and invade the surrounding stroma. Migration is a highly orchestrated process in which cells are guided by b

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Patel, Sagar. "THE MECHANOTRANSDUCTION OF PRIMARY CILIA IN TUMOR PROGRESSION OF LUNG ADENOCARCINOMA." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3071.

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The objective of this study was to investigate primary cilia and their mechanotransduction role in lung adenocarcinoma tumor progression. The main focus investigated the effect of primary cilia on cell cycle progression, survival, adhesion and migration analysis of these cells and the role of sonic hedgehog signaling pathway in mechanotransduction. Human Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma biopsies contain more primary cilia than non-tumor lung sections. To observe the effects of primary cilia presence in lung cancer cells in-vitro, formation of primary cilia is inhibited using

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Stephenson, Natalie. "Mechanotransduction of the Notch signalling pathway via the negative regulatory region." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/mechanotransduction-of-the-notch-signalling-pathway-via-the-negative-regulatory-region(c13c0f01-3095-4895-a536-1dfc324d9899).html.

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Abstract:

The Notch receptor is part of a highly conserved omnipresent developmental pathway that has crucial roles in developing and self-renewing tissues. During activation of the signalling pathway Notch binds to its ligand, presented on a neighbouring cell. It is thought that this results in a conformational change within the Negative Regulatory Region (NRR) unmasking a key proteolytic site (S2) and allows for metalloprotease cleavage. This facilitates further cleavage by gamma-secretase, initiating downstream events. Thus far, the molecular mechanism by which the S2 site is revealed has not been de

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