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1

Linderberg, Kerstin. Läsglädje med lättläst: 300 nya böcker för lässvaga vuxna. 5th ed. Bibliotekstjänst, 1993.

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2

Carral, Michel. Ge ome trie: Cours et plus de 300 exercices avec solutions. Ellipses, 1995.

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3

Se elige?: 300 preguntas y respuestas sobre la homosexualidad. Random House Español, 2001.

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4

Carton, James. Multisystem diseases. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199591633.003.0018.

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Systemic lupus erythematosus 346Systemic sclerosis 348Sarcoidosis 349Vasculitis 350• A multisystem autoimmune disease characterized by autoantibody production against a number of nuclear and cytoplasmic autoantigens.• Incidence of 4 per 100,000 people per year.• Most cases occur in women of childbearing age....
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5

Qureshi, Norman, and Kim Rajappan. Sudden cardiac death. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0120.

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Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac disease, in a patient with or without known cardiac disease and which occurs within 1 hour from the appearance of the first clinical symptoms. The sudden cessation of cardiac activity leads to haemodynamic collapse, typically due to sustained ventricular tachyarrhythmias. The event is described as an aborted SCD (or sudden cardiac arrest) when an intervention (e.g. defibrillation) or spontaneous reversion restores circulation. The lack of uniformity with this definition complicates SCD statistics. By convention, the use of SCD to describe both fatal and non-fatal cardiac arrests persists. SCD continues to be a leading cause of death in Western countries, and accounts for 15%–20% of all natural deaths in adults in the US and Western Europe, and up to 50% of all cardiovascular deaths. In the US, estimates of SCDs from retrospective death certificate analyses range from 300 000 to 350 000 annually, giving an incidence of 0.1%–0.2% per year amongst the population above the age of 35 years. Event rates are said to be similar in Europe, although worldwide incidence is difficult to estimate and varies in accordance to the prevalence of CHD. The incidence of SCD increases with age and underlying cardiac disease. There is also a male preponderance, with men 2–3 times more likely to experience SCD than women, and this reflects the higher incidence of CHD in men.
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6

Singh, Ajay K., and Joseph Loscalzo, eds. The Brigham Intensive Review of Internal Medicine. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199358274.001.0001.

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Based upon the popular review course from Harvard Medical School, this online resource is a comprehensive study guide for the American Board of Internal Medicine certification or maintenance of certification examination, as well as for general practice review by physicians and residents. Authoritative and thorough, it provides in-depth coverage across all specialties of internal medicine, including endocrinology, neurology, hepatology, rheumatology, gastroenterology, and more. It features numerous tables and figures, and detailed discussions with emphasis on essential learning points. It features over 350 board review questions, numerous tables and figures, detailed discussions with emphasis on essential learning points, and there is a further section dedicated to board simulation.
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7

Camm, A. John, Thomas F. Lüscher, Gerald Maurer, and Patrick W. Serruys, eds. ESC CardioMed. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.001.0001.

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ESC CardioMed is a ground-breaking initiative from European Society of Cardiology together with Oxford University Press that transforms reference publishing in cardiovascular medicine in order to better serve the needs of this rapidly advancing specialty. ESC CardioMed is an encyclopedic online resource covering more than 60 disciplines within cardiology. It will be updated online 3 times a year by the world’s leading clinicians, scientists, and researchers to reflect the latest in global cardiology. More than 1000 of the world’s leading specialists, ranging from researchers to clinicians, have contributed to this vast publication, ensuring a comprehensive and authoritative treatment of the field. ESC CardioMed is highly illustrated, with over 350 videos, helping readers to visualise key concepts. The publication is also linked to the ESC Clinical Practice Guidelines in the European Heart Journal, providing the background information behind clinical practice.
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8

Kahlos, Maijastina. Religious Dissent in Late Antiquity, 350-450. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190067250.001.0001.

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Religious Dissent in Late Antiquity reconsiders the religious history of the late Roman Empire, focusing on the shifting position of dissenting religious groups. The groups under consideration are non-Christians (‘pagans’) and deviant Christians (‘heretics’). The period from the mid-fourth century until the mid-fifth century CE witnessed a significant transformation of late Roman society and a gradual shift from the world of polytheistic religions into the Christian Empire. This book demonstrates that the narrative is much more nuanced than the simple Christian triumph over the classical world. It looks at everyday life, economic aspects, day-to-day practices, and conflicts of interest in the relations of religious groups. The book addresses two aspects: rhetoric and realities, and consequently delves into the interplay between the manifest ideologies and daily life found in late antique sources. We perceive constant flux between moderation and coercion that marked the relations of religious groups, both majorities and minorities, as well as the imperial government and religious communities. Religious Dissent in Late Antiquity is a detailed analysis of selected themes and a close reading of selected texts, tracing key elements and developments in the treatment of dissident religious groups. The book focuses on specific themes, such as the limits of imperial legislation and ecclesiastical control, the end of sacrifices, and the label of magic. It also examines the ways in which dissident religious groups were construed as religious outsiders in late Roman society.
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9

Kahn, S. Lowell. End of the Road: Bailout Techniques for the Short Wire. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0060.

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Guidewires for peripheral interventions come in a variety of lengths for the 0.035/0.038-, 0.018-, and 0.014-in. platforms. Common lengths include 75/80, 145, 180, 200, 260, 300, and 330 cm. Whereas a navigation wire needs only to be slightly longer than the catheter in use, guidewires over which exchanges are necessary for intervention need to be considerably longer. As a general rule, a guidewire should be long enough to be passed sufficiently beyond the treatment zone (e.g., occlusion) to facilitate adequate support with enough wire external to the patient to allow for any desired catheter or balloon use/exchange (e.g., 150 cm for a typical tibial balloon). This chapter elaborates on techniques to overcome a short wire obstacle during procedures.
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10

Lai, Kar Neng, and Sydney C. W. Tang. Immunoglobulin A nephropathy. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0065.

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Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis. It runs a slow and sometimes relentless clinical course with consequent end-stage renal failure in 35–40% of patients 25–30 years after first clinical presentation. The pathology is characterized by deposition of macromolecular (polymeric) IgA1 in the glomerular mesangium, proliferation of mesangial cells, increased synthesis of extracellular matrix, and infiltration of macrophage, monocytes, and T cells.
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11

Chambers, John. Aortic aneurysm. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0102.

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The epidemiology and natural history of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are different. The thoracic aortic diameter is dependent on age and body habitus as well as the level at which it is measured. Average diameters are 2.1 cm/m2 for the ascending thoracic aorta, and 1.6 cm/m2 for the descending thoracic aorta, giving approximate thresholds for the diagnosis of a TAA of 40 mm and 35 mm, respectively. AAAs are defined by a diameter >30 mm and are mainly infrarenal, with only 2%–5% in a suprarenal position.
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12

Richette, Pascal. Principles of gout management. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0044.

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The general goals of gout therapy are to manage acute flares and to prevent recurrences and prevent or reverse the complications of urate deposition by lowering urate levels. The choice of drug should be made on the basis of the patient’s co-morbidities, other medications, and side effect profile. Treatment of flares can be achieved with non-steroidal anti-inflammatory drugs, colchicine, or corticosteroids (systemic or intra-articular). Interleukin-1 blockers could become an alternative in patients contraindicated for traditional anti-inflammatory agents. Lowering of urate levels below monosodium urate (MSU) saturation point with both a non-pharmacological and pharmacological approach allows to dissolve MSU crystals and to cure gout. Serum urate (SUA) levels should be maintained below 6 mg/dL (360 μ‎mol/L) or below 5 mg/dL (300 μ‎mol/L) in patients with severe gout to facilitate faster dissolution of crystals. Urate-lowering therapy (ULT) should be initiated close to the first diagnosis of gout. Allopurinol and febuxostat are the most widely used xanthine oxidase inhibitors to lower SUA levels. If the SUA target cannot be reached by these agents, uricosurics are indicated, either alone or in combination with a xanthine oxidase inhibitor. In patients with severe tophaceous gout in whom the SUA target cannot be reached with any other available drug, pegloticase is indicated. Since ULT initiation may trigger acute attacks of gout, prophylaxis with an anti-inflammatory agent is recommended, mostly with low-dose colchicine. Of note, patient education, appropriate lifestyle advice, and treatment of comorbidities are also important parts of the management of patients with gout.
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13

Winsley, Richard J. Overtraining syndrome. Edited by Neil Armstrong and Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0038.

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Prevalence rates of overreaching/overtraining syndrome in young athletes are ~30–35%, and burnout ~5–10%, indicating that a significant minority of young athletes are thus affected at some time during their sporting careers. Presenting symptoms vary considerably, most commonly including a sustained reduction or stagnation in performance, increased perception of effort during exercise, feelings of muscle heaviness, frequent upper respiratory tract infections, persistent muscle soreness, mood changes, sleep disturbance, and loss of appetite. Excessive training is not always the cause and both training and non-training stressors need to be considered as potential culprits. Power imbalances, single identity, early specialization, coach and/or parent pressure, conditional love, perfectionism, and entrapment may all help explain overtraining in childhood and adolescence. Screening and prevention strategies should take a holistic overview of the young athlete’s sporting environment in order that he/she continues to enjoy and develop in their chosen sport(s).
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14

Smedley, Julia, Finlay Dick, and Steven Sadhra. Haematological disorders. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199651627.003.0015.

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Bone marrow aplasia 324Anaemia 326Methaemoglobinaemia 328Haemolysis 329Haematological malignancies 330•Ionizing radiation: acute (usually accidental) exposure to a dose of ionizing radiation above ~0.2Sv produces marrow hypoplasia/aplasia as a deterministic (dose-related) effect.• nuclear industry• medical radiography and nuclear medicine...
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15

Butler, Gary, and Jeremy Kirk. Endocrine investigations and laboratory reference ranges. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199232222.003.0101.

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General guidelines 330GH provocation tests 331Tests for GH secretion 332IGF-1 generation test 334Oral glucose tolerance test for investigating excess GH secretion 335TRH test 336LHRH/GnRH (gonadotropin-releasing hormone) stimulation test 337Triple pituitary stimulation test 338Water deprivation test (WDT) 340...
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16

Wilson, John W., and Lynn L. Estes. Occupational Postexposure Prophylaxis and Management. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0151.

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• Human immunodeficiency virus (HIV) transmission risk is about 0.3% (about 1 in 300)• About 0.1% after mucous membrane exposure• <0.1% after exposure to abraded skin• Hepatitis B virus (HBV) for nonvaccinated persons when blood from source is:• HBsAg (hepatitis B surface antigen) positive ...
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17

Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Hepatitis B. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0057.

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Epidemiology 418Transmission 418Clinical features 418Interpretation of HBV serology 419Complications 419Prevention 421Management of chronic HBV infection 422• About 2 billion people (1/3 of the world population) show evidence of exposure to hepatitis B virus (HBV) infection, with 300–400 million showing evidence of chronic HBV infection....
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18

Vernon, David. Emerging Adult Essay. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780190260637.003.0038.

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Five a.m. is early, and 4:30 a.m. is even earlier. At the mere age of 11, a 4:30 a.m. wake up was commonplace on a Saturday morning. Growing up in mining towns, literally the middle of nowhere, made it near on impossible to pursue my dreams of playing professional cricket. Especially when the game started at 7:30 in the morning, 300 kilometers from where I lived. Though mornings were tough for me, I can’t imagine the pain and struggle my parents went through. I’m sure that after working 80 hours all week, the last thing they wanted to do was jump in a car at 4:30 on a Saturday morning. I was extremely fortunate to grow up in Australia in the 1990s as part of a very supportive, working middle-class family....
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19

It's a Guy Thing: More Than 300 Tics, Traits, and Tendencies That Uniquely Define Men. Towlehouse Publishing Company, 2001.

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20

Mead Preschool Workbook, 10-7/8 x 8-3/8-Inches, 320 Pages (48054). Mead, 2015.

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21

(Editor), Robert Fossier, and Janet Sondheimer (Translator), eds. The Cambridge Illustrated History of the Middle Ages Volume I, 350-950. Cambridge University Press, 1989.

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22

Hallett, Christopher H. Roman Nude: Heroic Portrait Statuary 200 BC - AD 300. Oxford University Press, 2011.

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23

Siebert, Lynn Laitman. Kiss Me, Kate. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252040092.003.0015.

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This chapter examines Porter's Kiss Me, Kate. Written in 1948, it holds a unique place in Porter's career and represents the fullest flowering of his mature talent. Porter met the challenge of the “new style musical comedy” by composing Kiss Me, Kate and simultaneously surpassed his past triumphs while establishing a new standard for the genre. The score's subtle refinement, depth of expression, and inventiveness, as well as the total integration of music, lyrics, and libretto, distinguish Kiss Me, Kate as Porter's masterwork. Kiss Me, Kate opened on Broadway at the New Century Theatre on 30 December 1948, with a run of 1,077 domestic performances and subsequent international performances.
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24

Sybert, Virginia. Genetic Skin Disorders. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780195397666.001.0001.

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This lavishly-illustrated resource represents a comprehensive survey of well over 300 distinct inherited dermatologic conditions. Each disease entry follows a consistent format, containing sections devoted to dermatologic features, associated clinical abnormalities, histopathology, biochemical and molecular information, treatment, mode of inheritance and recurrence risk, prenatal diagnosis, and information on differential diagnosis. Any clinician faced with a patient in whom the possibility for a genetic disorder of the skin exists will find this book a practical tool of immense interest.
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25

Waldmann, Carl, Neil Soni, and Andrew Rhodes. Physical disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199229581.003.0029.

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Hypothermia 498Drowning and near-drowning 500Rhabdomyolysis 502Pressure sores 504Defined as core temperature <35°CMild 32–35°C; moderate 26–32°C; severe <26°CIncreasing age, abnormal mental state, immobility (orthopaedic, Parkinsonism), drugs (alcohol, barbiturate, major tranquillizers, antidepressants), endocrine (hypothyroidism, hyperglycaemia, adrenal insufficiency, hypopituitarism), autonomic neuropathy (diabetes mellitus, Parkinsonism), malnutrition, renal failure, sepsis (excessive heat loss from vasodilatation), exposure (inadequate clothing/eating, near drowning)....
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26

Brêtas, Anilce de Araújo. Balanço eletrolítico estratégico na ração de suínos criados em clima quente. Brazil Publishing, 2021. http://dx.doi.org/10.31012/978-65-5861-318-3.

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The effect of Dietary Electrolyte Balance (EB) in rations for growing and finished swine under high temperatures ambient was evaluated. Two hundred male castrated pigs with initial average 25,3±1.3 kg were allotted in completely randomized experimental design with five treatments T1 diet without supplemented electrolyte 191 mEq/kg; T2 (supl B) diet supplementd with sodium bicarbonate (NaHCO3) 250 mEq/kg; T3 (supl B+C) diet supplemented with (NaHCO3) and potassium chloride (KCl) 250 mEq/kg; T4 (supl B) diet supplemented with (NaHCO3) 300 mEq/kg; T5 (supl B+C) diet supplemented (NaHCO3) and (KCl) 300 mEq/kg and four replication and 10 pigs per experimental unit. The average weight of the animals was 68,8±3,4 kg. The performance parameters evaluated were the feed intake (FI), the daily gain (DG), finished weight (FW), nitrogen intake (NI), lysine intake (LI), efficiency of N utilization for weight gain (ENUWG), efficiency of L utilization for weight gain (ELUWG) and the gain:feed ration and physiologic parameters to respiratory frequency (RF) and rectal temperature (RT). Blood was colleted to measure serum concentration of Na, Cl and K. The average temperature was 29,65±1,80ºC with (RU) of 69,6±10,4%. The levels of EB decreased (P<0,05) the (FI) and improved (NI). The others performance parameters evaluated weren’t influenced by treatments (P>0,05). In the termination phase the supplementation with sodium bicarbonate and or potassium chloride with 250 or 300 mEq/kg can be used to correct electrolyte balance under heat stress.
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27

Ferner, Robin, and Anthony Cox. Drug-induced neurological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0240.

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An adverse drug reaction is defined as ‘an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product; adverse effects usually predict hazard from future administration and warrant prevention, or specific treatment, or alteration of the dosage regimen, or withdrawal of the product’ (p. 1255, Edwards IR and Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet 2000; 356: 1255–9). Adverse drug reactions can cause or contribute to central and peripheral nervous system disorders, including traumatic, infective, neoplastic, demyelinating, and vascular diseases.
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28

Janik, Luke S., Somaletha T. Bhattacharya, and Laura A. Downey. Gastrointestinal System. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199398348.003.0007.

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29

Takač, Iztok, Ksenija Geršak, Darja Arko, and Vida Gavrić Lovrec, eds. Izpitna vprašanja iz ginekologije in perinatologije. University of Maribor Press, 2021. http://dx.doi.org/10.18690/978-961-286-494-1.

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Učno gradivo lzpitna vprašanja iz ginekologije in perinatologije je prvo tovrstno gradivo v Sloveniji, v katerem so sistematsko zbrana vprašanja z odgovori, ki se uporabljajo pri izpitu iz ginekologije in porodništva na dodiplomskem študiju medicine. Učno gradivo je delo 23 avtorjev, specializantov ginekologije in porodnistva. Uredili so ga štirje uredniki, v njem pa je zbranih 3520 vprašanj z vseh področij ginekologije, porodništva in neonatologije, zbranih v 88 poglavjih. Med odgovori na vprašanja je pravilen le en najustreznješi odgovor (ang. single best answer - SBA). Gre za obliko preverjanja znanja, pri kateri se kandidatu zastavi vprašanje z nekaj možnimi odgovori, med katerimi je samo eden najbolj pravilen. Vprašanja in odgovori bodo lahko služili tudi za preverjanje znanja študentov drugih strok, kot so zdravstvena nega, fizioterapija in podobno, dobrodošla pa bodo tudi specializantom ginekologije in porodništva za preverjanje znanja v času priprave na specialistični izpit.
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30

Caligula: The Mad Emperor of Rome. Turner Publishing Company, 2019.

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31

Shaibani, Aziz. A Video Atlas of Neuromuscular Disorders. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199898152.001.0001.

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This online title is the first real cases video atlas of neuromuscular disorders. It contains close to 300 video cases taken directly from a real neuromuscular clinic, illustrating a myriad of disorders and shedding light on their diagnosis and treatment, as well as providing updates about many of them. It provides an invaluable approach that should benefit anyone interested in neuromuscular disorders which comprise more than 50% of presenting disease to general neurologists and even to general practitioners. Some rare diseases are also described, giving an opportunity for future diagnosis of these conditions in patients, despite the rarity of the condition and its infrequent presentation in clinic.
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32

Wise, Matt, and Paul Frost. Hypothermia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0078.

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Hypothermia is defined by a core body temperature of <35.0°C, and may be further characterized as mild (32.0°C–34.9°C), moderate (28.0°C–31.9°C), or severe (<28.0°C). Primary hypothermia is the result of environmental exposure, while in secondary hypothermia there is an underlying medical condition which perturbs thermoregulation. Mild hypothermia (32.0°C–34.0°C) is used as a therapeutic modality in intensive care for traumatic brain injury (to lower intracranial pressure) and following out-of-hospital cardiac arrest (to improve neurological outcomes). Hypothermia and even hypothermic circulatory arrest are also used during cardiac surgery and aortic root replacement surgery.
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33

Shaibani, Aziz. A Video Atlas of Neuromuscular Disorders. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190661304.001.0001.

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This online title is the first real cases video atlas of neuromuscular disorders. It contains close to 300 video cases taken directly from a real neuromuscular clinic, illustrating a myriad of disorders and shedding light on their diagnosis and treatment, as well as providing updates about many of them. It provides an invaluable approach that should benefit anyone interested in neuromuscular disorders which comprise more than 50% of presenting disease to general neurologists and even to general practitioners. Some rare diseases are also described, giving an opportunity for future diagnosis of these conditions in patients, despite the rarity of the condition and its infrequent presentation in clinic.
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34

Delcourt, Candice, and Craig Anderson. Management of parenchymal haemorrhage. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0237.

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Parenchymal intracerebral haemorrhage (ICH) affects several million people in the world each year, most of whom reside in developing countries. ICH accounts for 10-40% of strokes and is the least treatable form of stroke with a 30-day mortality of 30-55%, with half of these deaths occurring within the first few days of onset. . High blood pressure is both a causal and prognostic factor for ICH, with early control of hypertension being the only medical treatment which may improve recovery and the level of residual functioning. The role of surgery remains controversial. Management is largely supportive and aimed at reducing further brain injury and preventing complications.
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35

Speakman, Mark. Urinary retention in men. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0056.

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Urinary retention continues to be a significant burden for both the patient and healthcare services in the United Kingdom and around the world. It is associated with a significant reduction in patients’ quality of life. In the past (20–30 years ago) urinary retention was regarded as an immediate indication for surgery and in older reports, 25% to 30% of men who underwent transurethral prostatectomy (TURP) had acute urinary retention (AUR) as their main indication. With the introduction of medical treatments and changes in practice for the management of retention, these rates have changed significantly. Key topics discussed in this chapter include the aetiology, pathogenesis, presentation, initial assessment, investigation, management, and prevention of urinary retention in men.
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36

Kibbler, Christopher C. Fungal toxin-mediated disease. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0031.

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More than 300 mycotoxins have been described, and increasing numbers have been shown to cause disease in humans. They may cause organ failure, carcinogenesis, mutagenesis, and immunosuppression, or have oestrogenic effects. Exposure may occur through ingestion of preformed toxin in contaminated foodstuffs, ingestion of toxic mushrooms, or inhalation of airborne toxins in damp environments This chapter discusses food-borne mycotoxin disease, mushroom poisoning, and the potential impact on health of environmental exposure to airborne mycotoxins. It is intended to provide a background and understanding of these conditions, about which there is a relative ignorance amongst healthcare professionals. However, their clinical management requires the expertise of mycologists and toxicologists to ensure an optimum outcome.
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37

Parnas, Josef. Introduction to “Depression in a biopsychosocioeconomic context”. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198725978.003.0034.

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Chapter 34 is an introduction to Chapter 35, which covers how the concept of depression still remains controversial, primarily due to its complicated composition involving not only medical/nosological factors but also significant nonmedical factors.
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38

Beattie, R. Mark, Anil Dhawan, and John W.L. Puntis. Neonatal jaundice. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569862.003.0047.

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Epidemiology 340Unconjugated hyperbilirubinaemia 340Specific conditions 342Conjugated hyperbilirubinaemia 343Idiopathic neonatal hepatitis 347• 30–50% of normal term newborns are jaundiced after birth.• Physiological and breast milk jaundice account for the majority of cases.• 1 in 2500 infants has conjugated hyperbilirubinaemia....
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39

Cuckow, Peter. Hypospadias. Edited by David F. M. Thomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0121.

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Hypospadias is one of the commonest congenital anomalies, with an incidence of approximately 1:250–300. Approximately 80% of cases are of mild to moderate severity and are amenable to single-stage surgical correction at around one year of age. Proximal or complicated cases account for the remaining 20% and these are being increasingly managed by a two-stage approach. While successful surgical repair can help to minimize any long-term psychological morbidity, a minority of patients will nevertheless experience significant psychological problems related to their condition. Long-term follow-up and support may therefore be beneficial for patients with severe forms of hypospadias. The experience and commitment of the surgeon, coupled with regular audit of results are the most important determinants of a successful surgical outcome.
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40

Verrips, Aad. Cerebrotendinous Xanthomatosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0040.

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Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disease due to a defect in bile acid metabolism. Worldwide, more than 300 patients have been described. Mutations in the CYP27A1 gene result in sterol 27-hydroxylase deficiency leading to the accumulation of cholestanol in multiple body tissues. Premature cataracts, chronic diarrhea, tendon xanthomas, and neurological deterioration are the predominant clinical features. There are several disease stages, from being nearly asymptomatic in the early childhood years to severe disability in later stages of life. Adult CTX patients are often misdiagnosed initially, especially when tendon xanthomasa are absent. CTX should be considered in all patients with premature cataracts and in patients with neurological features such as spasticity, early-onset dementia, ataxia, or Parkinsonism.
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41

Wilson, Andrew, and Alan Bowman. Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198790662.003.0001.

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The introduction sets the contributions of this volume within the context of scholarly debate over the scale, nature, and importance of Roman trade since the mid-twentieth century, and highlights the conceptual links and common leitmotifs between papers in the volume. The focus is on the period from c.100 BC to AD 350, and in particular the role of the Roman state in commerce, in shaping the institutional framework for trade within and outside the Empire, in taxing that trade, and in intervening in the markets to ensure the supply of particular commodities, especially for the city of Rome and for the army.
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42

Turkheimer, Eric. What do we want from a depression diagnosis? Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198725978.003.0036.

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Chapter 36 is a commentary on Chapter 35, which covers how the concept of depression still remains controversial, primarily due to its complicated composition involving not only medical/nosological factors but also significant nonmedical factors, and what is wanted in a diagnosis of depression.
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43

Herrington, William G., Aron Chakera, and Christopher A. O’Callaghan. Nephrotic syndrome. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0161.

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Nephrotic syndrome is a clinical syndrome of heavy proteinuria (greater than 3.5 g per 24 hours), oedema, and hypoalbuminaemia, which is associated with hyperlipidaemia and a procoagulant state. Causes of nephrotic syndrome are traditionally classified by their histopathological descriptions. In most cases, the histological picture can have a primary (idiopathic) or secondary cause. Minimal change, membranous nephropathy, and focal segmental glomerulosclerosis account for over 60% of cases. Diabetic nephropathy and renal amyloidosis are common secondary causes of nephrotic syndrome. Nephrotic-range proteinuria will show up as at least 3+ protein on urinalysis. The diagnosis is confirmed by a urinary protein-to-creatinine ratio over 300 mg/mmol, and hypalbuminaemia. In adults, renal biopsy is the diagnostic test. This chapter addresses the causes, diagnosis, and management of nephrotic syndrome in adults.
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Abramowicz, A. Elisabeth. Endovascular Thrombectomy in Acute Ischemic Stroke. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0009.

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Endovascular thrombectomy (EVT) for acute ischemic stroke is a new and powerful treatment modality that restores functional independence to many victims. Although it has been proved of value in large-vessel occlusion of the anterior circulation, it is also used in basilar artery embolism. Time to successful reperfusion is a major determinant of recovery. A subset of patients has robust collaterals and will benefit from treatment up to 24 hours after stroke onset; the presence of salvageable brain tissue (penumbra) must be ascertained by specialized imaging. The number of patients who can benefit from EVT is estimated at 100,000/year in the United States alone in more than 300 designated Thrombectomy-Capable Stroke Centers. EVT is a new anesthetic emergency. Anesthesiologists must be actively involved in creating protocol-driven care for acute ischemic stroke patients.
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Bovet, Emilie. What can history and social studies of sciences teach us about evolutionary psychiatry? Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198725978.003.0030.

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Chapter 30 is a commentary on Chapter 29, which covers explores the application of evolutionary ideas to psychiatry, including evolutionary psychiatry, evolutionary psychology, neo-Darwinism, developmental systems theory, developmental plasticity, human nature, and process philosophy, and what history and social studies of sciences teach us about evolutionary psychiatry.
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Wilson, John W., and Lynn L. Estes. Tick-Borne Infections. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0155.

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Numerous species of ticks have been associated with transmission of infectious diseases to humans. Recognizing the type of tick and its geographic distribution can aid identification of select bacterial, viral, and protozoan infection risk assessment.• Consists of the hard ticks that transmit nearly all tick-borne human diseases; 2–30 mm...
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Jones, Michael, Norman Qureshi, and Kim Rajappan. Ventricular tachyarrhythmias: Ventricular tachycardia and ventricular fibrillation. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0118.

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Ventricular tachyarrhythmias are abnormal patterns of electrical activity arising from the ventricular tissue (myocardium and conduction tissue). Ventricular tachycardia (VT) is an abnormal rapid heart rhythm originating from the ventricles. The rhythm may arise from the ventricular myocardium and/or from the distal conduction system. The normal heart rate is usually regular, between 60 and 100 bpm, and there is synchronized atrial and ventricular contraction. In VT, the ventricles contract at a rate greater than 120 bpm and typically from 150 to 300 bpm, and are no longer coordinated with the atria. There is still organized contraction of the ventricles in VT, with discrete QRS complexes. It is a potentially life-threatening arrhythmia, with the risk of degenerating into ventricular fibrillation and resulting in sudden cardiac death. It is characterized by a broad-complex tachycardia on ECG.
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Ajzensztejn, Daniel. Prostate cancer. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0326.

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Prostate cancer is the commonest male malignancy, with approximately 35 000 new cases in the UK annually, equating to a lifetime risk of 1 in 10. When diagnosed early, it has a high chance of cure with surgery, external beam radiotherapy, or brachytherapy. Even for metastatic disease, the prognosis is usually several years.
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Kellner, Birgit. Proving Idealism Dharmakīrti. Edited by Jonardon Ganeri. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199314621.013.18.

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The existence of the external world is a major contested issue among Buddhist and Brahmanical thinkers in the logico-epistemological period of Classical Indian philosophy (c.5th–12th century ce). Buddhist philosophers aligned with the idealist Yogācāra-Vijñānavāda tradition refuted external objects with different methods and arguments. Two philosophers who contributed significantly to the discussion are Vasubandhu (probably between 350 and 420 ce) and Dharmakīrti (between mid-6th and mid-7th century ce), who was one of the two main figures in the logico-epistemological or pramāṇa school. Vasubandhu’s refutation of external objects in his Viṃśikā Vijñaptimātratāsiddhiḥ has been interpreted as an argument from ignorance that external objects do not exist because there is no evidence for their existence. Dharmakīrti’s main arguments against external objects from Pramāṇavārttika and Pramāṇaviniścaya are different. Investigating them in light of his elimination of arguments from ignorance from his own and original logical theory offers new possibilities for appreciating his stance on idealism.
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Harvey, Peter. The Buddhist Just Society. Edited by Daniel Cozort and James Mark Shields. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198746140.013.15.

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Buddhism posits a basic equality of sentient beings as faced with suffering and in need of liberation. It also regards humans in particular as having a precious kind of rebirth with great potential for liberation in spite of their different karmic backgrounds. Respect for others is seen in the reflection, ‘For a state that is not pleasing or delightful to me, how could I inflict that on another?’ (SN V.353–354; Harvey 2000: 33–34). This is given as a reason for not inflicting wrong action or wrong speech on others. This chapter discusses Buddhist ideals on good social relationships and the good governance of society, in which a government should seek to prevent poverty, punish crime in a way that is reform-orientated and compassionate yet effective, and sets an ethical example. It includes a discussion of attitudes to capital punishment, democracy, and the extent to which the law should encode ethics.
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