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Journal articles on the topic 'MED 560'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Vinkler, Jonatan. "Češki bratje – 560 let II: Po Luthrovem nastopu – med reformo in politiko." Stati inu obstati, revija za vprašanja protestantizma 14, no. 28 (December 26, 2018): 83–106. http://dx.doi.org/10.26493/2590-9754.14(28)83-106.

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2

Classen, Albrecht. "The Monster Theory Reader, ed. Jeffrey Andrew Weinstock. Minneapolis, MN, and London: University of Minnesota Press, 2020, ix, 560 pp." Mediaevistik 33, no. 1 (January 1, 2020): 335–36. http://dx.doi.org/10.3726/med.2020.01.57.

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3

Aisu, Naoya, Yoichiro Yoshida, Toru Miyake, Syu Tanimura, Seiichiro Hoshino, and Yuichi Yamashita. "Effect of coinfusion of dexamethasone to oxaliplatin on hypersensitivity reactions induced by oxaliplatin in patients with colorectal cancer treated with XELOX." Journal of Clinical Oncology 31, no. 4_suppl (February 1, 2013): 560. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.560.

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560 Background: Oxaliplatin is a third-generation platinum compound and a key agent for the management of colorectal cancer. Patients treated with oxaliplatin are at risk for hypersensitivity reactions. The incidence of severe anaphylactic reaction of oxaliplatin is estimated to be 0.5%, whereas the incidence of other hypersensitivity reactions in clinical practice is estimated to be 12% to 20%. We have reported that there is possibility that hypersensitivity reactions to oxaliplatin could have been prevented by co-infusion of dexamethasone (DEX) (Yoshida et al.2012 ASCO-GI, Yoshida et al, Br J Med Med Res 2012) but just in a small cohort. This study was undertaken to evaluate the effectiveness of co-infusion of DEX to oxaliplatin for controlling hypersensitivity reactions caused by the administration of oxaliplatin. Methods: A retrospective study of patients with advanced colorectal cancer who received XELOX was performed. The study included 101 patients who received XELOX or XELOX +bevacizumab therapy for advanced or recurrent colorectal cancer. In all the patients, oxaliplatin (130mg/m²) was administered in combination with DEX (6.6mg) via the peripheral vein. Results: A total of 101 patients were studied. Hypersensitivity reactions developed in 2 patients (1.98%).Respiratory symptoms, ocular symptoms and anaphylaxis were not observed in 101 patients. Two patients experienced cutaneous reaction (erythema). Grade 3 or higher hemotoxicity was noted in 13.9% of the patients, and grade 3 or higher nonhematological toxicity was noted in 17.8% of the patients. The response rate was 55.4%. Conclusions: Co-infusion of dexamethasone to oxaliplatin reduced oxaliplatin-related hypersensitivity reactions. This effective approach should be considered for all patients who receive XELOX, allowing treatment to be completed as planned. We have already started a new phase II trial to confirm the effects of DEX to prevent the hypersensitivity.
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Classen, Albrecht. "Die Kaiser und die Säulen ihrer Macht: Von Karl dem Grossen bis Friedrich Barbarossa, hrsg. von der Generaldirektion Kulturelles Erbe Rheinland-Pfalz und Bernd Schneidmüller. Darmstadt: wbg Theiss, 2020, S. 560, ca. 380 farbige Ill." Mediaevistik 33, no. 1 (January 1, 2020): 311–12. http://dx.doi.org/10.3726/med.2020.01.44.

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5

Kerwin, Edward M., Catherine Scott-Wilson, Lisa Sanford, Stephen Rennard, Alvar Agusti, Neil Barnes, and Courtney Crim. "Corrigendum to “A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD” [Respir Med, 107 (2013) 560–569]." Respiratory Medicine 107, no. 12 (December 2013): 2094. http://dx.doi.org/10.1016/j.rmed.2013.10.008.

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6

Silva, Thaiano I. S., Victor V. Valério de Carvalho, Alexandre Perdigão, Tiago S. Acedo, Guilherme S. F. M. Vasconcellos, Luis Fernando Tamassia, Cyntia L. Martins, Mário B. Arrigoni, and Danilo D. Millen. "212 Feedlot performance of Nellore bulls fed different starch levels in the diet associated with feed additives." Journal of Animal Science 98, Supplement_4 (November 3, 2020): 161. http://dx.doi.org/10.1093/jas/skaa278.295.

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Abstract This study, conducted at DSM Beef Center, Mato Grosso do Sul, Brazil, was designed to evaluate the effects of different starch levels in the diets associated to feed additives on performance of Nellore bulls. The experiment was designed as a completely randomized block, with a 3 x 2 factorial arrangement of treatments, in which 210 18-mo-old yearling Nellore bulls (375.8 ± 16.8 kg) were fed in 30 pens (n = 7/pen), for 90 d according to the treatments: 25% starch (Low-S) + monensin (MON, 26 mg/kg DM); 35% starch (Med-S) + monensin; 45% starch (High-S) + monensin; Low-S + Essential Oils and amylase (CR, Crina®, 90 mg/kg DM and RumistarTM, 560 mg/kg DM, DSM Nutritional products); Med-S + CR; High-S + CR. Each treatment was replicated five times. Weight assessments were performed at day 0 and 90 of the study after 14 h fasting. A significant interaction was observed for final BW (P = 0.04) and HCW (P = 0.01). Cattle fed Med-S and High-S diets containing CR had heavier carcasses than those fed Med-S + monensin (287.4 vs. 270.9 kg) and High-S + monensin (281.4 vs. 263.0 kg), respectively; however, bulls fed Low-S diets with either monensin or CR had similar HCW (P > 0.05, 279.9 vs. 282.8 kg, respectively). In addition, cattle fed CR had greater dressing percentage (P < 0.01; 55.4 vs. 54.6%) regardless of starch levels. An interaction was observed (P = 0.02) for ADG, in which cattle fed Med-S + CR had greater ADG (1.58 kg) than cattle fed MON across all starch levels (1.48, 1.37 and 1.28, respectively) and then those fed High-S + CR (1.48 kg/d; P < 0.01). Similar responses were observed for DMI (P = 0.02). Cattle fed monensin improved G:F in 2.7% compared to those fed CR (0.150 vs. 0.146, P = 0.02). In conclusion, Crina® and RumistarTM increases carcass production of feedlot cattle fed medium and high-starch diets.
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7

Classen, Albrecht. "nr="560"Inwardness, Individualization, and Religious Agency in the Late Medieval Low Countries: Studies in the Devotio Moderna and Its Contexts, ed. Rijcklof Hofman, Charles Caspers, Peter Nissen, Mathilde van Dijk, and Johan Oosterman Medieval Church Studies, 43. Turnhout: Brepols, 2020, x, 230 pp., 6 color plates, 9 b/w fig." Mediaevistik 33, no. 1 (January 1, 2020): 560–61. http://dx.doi.org/10.3726/med.2020.01.166.

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8

Brovelli, A., C. Seppi, A. Bardoni, C. Balduini, and H. U. Lutz. "Re-evaluation of the structural integrity of red-cell glycoproteins during aging in vivo and nutrient deprivation." Biochemical Journal 242, no. 1 (February 15, 1987): 115–21. http://dx.doi.org/10.1042/bj2420115.

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Results presented in this paper show that removal of white-cell contaminations from human red blood cells by filtration through cellulose [Beutler, West & Blume (1976) J. Lab. Clin. Med. 88, 328-333] is a necessity whenever red cells are incubated at elevated temperatures or haemolysed after density separation. Omission of this precaution results in proteolysis of sialoglycoproteins in membranes from less-dense (young), but not dense (old), subpopulations. This proteolytic damage occurs during haemolysis of the cytoplasmic domain of glycophorin. A different type of proteolysis occurs if white-cell-contaminated red cells are incubated in the absence of glucose at elevated temperatures. Red cells release sialoglycopeptides. This process is stimulated by Ca2+ ions and is accompanied by the release of vesicles that differ from spectrin-free vesicles [Lutz, Liu & Palek (1977) J. Cell Biol. 73, 548-560]. This sialoglycopeptide release is dependent on white-cell contamination and is not required for the release of spectrin-free vesicles.
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9

Lau, K. F. "Time dependence of prognostic values of gene-expression signatures for breast cancer." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 11085. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11085.

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11085 Background: Gene-expression signatures were shown to be prognostic and predictive for breast cancer but their performances over time have not been investigated. Methods: Recurrence score (RS) of oncotype, 70-gene profile (SGP) of Mammaprint, intrinsic subtype (IS) and wound signature (WS) were analyzed using a single dataset of 295 samples from Fan et al. (Fan et al. N Engl J of Med 2006; 355:560–9). Time-varying coefficient Cox models were used to estimate the time-dependent hazard ratios (HR) for relapse-free survival (RFS). Annualized RFS hazard rates were estimated using cubic splines. Concordance between RS and SGP was calculated for different intrinsic subtypes in all 295 samples and was evaluated in a subset of 173 ER+ samples not in the training set of SGP for unbiased comparison. Results: For the high risk groups of RS, SGP, IS and WS, hazard rates peaked around the 2nd year from surgery and decreased rapidly over time. For the low risk groups, hazard rates also peaked around the 2nd yr but remained fairly constant over time. Hazard ratios of high vs. low risk groups of RS at yr 2, 5 and 10 were 17.0 (8.4–34.0), 4.0 (2.0–8.0), 1.7 (0.83–3.4). For intermediate vs. low risk groups of RS, the corresponding HRs were 2.7 (1.1–7.0), 5.0 (1.1–7.4), 1.6 (0.63–4.2). Poor vs. good groups of SVP had HRs of 7.4 (4.5–12.1), 3.6 (2.2–5.9), 2.0 (1.2–3.3) at yr 2, 5, 10. HRs of Luminal B (LB), Basal-like (BL), HER2/ER- (HER2), Normal-like (NL) vs. Luminal A (LA) of Intrinsic Subtypes were 6.8 (4.0–11.5), 5.7 (3.2–10.0), 7.6 (4.0–14.1) and 1.7 (0.9–3.3) at yr 2. HRs at yr 5 were 4.0 (2.3–6.8), 0.7 (0.4–1.2), 1.1 (0.6–2.0) and 2.3 (1.2–4.4) respectively. For WS, HRs at yr 2, 5, 10 were 6.3 (3.3–11.9), 2.9 (1.6–5.6) and 2.2 (1.2–4.1) respectively. Concordance rates of RS and SVP were 1.0, 0.91, 0.86, 0.72 and 0.62 for BL, HER2, LB, LA, NL of Intrinsic Subtypes. In 173 ER+ samples not present in the SGP training set, concordance rate between RS and SVP was 0.77 (Cramer's V = 0.56); the same as in the whole set of 225 ER+ patients (Fan et al. N Engl J of Med 2006; 355:560–9). Conclusions: Prognostic values of gene-expression signatures decrease over time. They can best predict breast cancer relapse during the first 5 years. Concordance between RS and SPV is highest in the basal-like tumors and lowest in the Luminal B and Normal-like subtypes. No significant financial relationships to disclose.
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Atkinson, Greg, and Alan Nevill. "Comments - re: Vehrs, P., Morrow, J. R., Butte, N.: Reliability and Concurrent Validity of Futrex and Bioelectrical Impedance. Int J Sports Med 19: 560-566,1998." International Journal of Sports Medicine 20, no. 05 (July 1999): 339–40. http://dx.doi.org/10.1055/s-2007-971141.

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11

Chiao, Stephanie, Howard Kipen, William K. Hallman, David E. Pollio, and Carol S. North. "Anthrax Exposure, Belief in Exposure, and Postanthrax Symptoms Among Survivors of a Bioterrorist Attack on Capitol Hill." Disaster Medicine and Public Health Preparedness 13, no. 03 (November 12, 2018): 555–60. http://dx.doi.org/10.1017/dmp.2018.115.

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ABSTRACTBackgroundFollowing chemical, biological, radiological, and nuclear disasters, medically unexplained symptoms have been observed among unexposed persons.ObjectivesThis study examined belief in exposure in relation to postdisaster symptoms in a volunteer sample of 137 congressional workers after the 2001 anthrax attacks on Capitol Hill.MethodsPostdisaster symptoms, belief in exposure, and actual exposure status were obtained through structured diagnostic interviews and self-reported presence in offices officially designated as exposed through environmental sampling. Multivariate models were tested for associations of number of postdisaster symptoms with exposure and belief in exposure, controlling for sex and use of antibiotics.ResultsThe sample was divided into 3 main subgroups: exposed, 41%; unexposed but believed they were exposed, 17%; and unexposed and did not believe that they were exposed, 42%. Nearly two-thirds (64%) of the volunteers reported experiencing symptoms after the anthrax attacks. Belief in anthrax exposure was significantly associated with the number of ear/nose/throat, musculoskeletal, and all physical symptoms. No significant associations were found between anthrax exposure and the number of postdisaster symptoms.ConclusionsGiven the high incidence of these symptoms, these data suggest that even in the absence of physical injury or illness, there may be surges in health care utilization. (Disaster Med Public Health Preparedness.2019;13:555-560)
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Potter, Laurie A. "Grateful MED 5.0." Government Publications Review 18, no. 3 (May 1991): 292–94. http://dx.doi.org/10.1016/0277-9390(91)90013-n.

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13

Rahman, M. Mushfequr, J. Ashraful Haq, MAH Golam Morshed, and Farida Huq. "Antibiotic Susceptibility Pattern of Bacteria Isolated from an Urban Referral Hospital in Dhaka City." Bangladesh Journal of Medical Microbiology 2, no. 2 (July 20, 2016): 7–11. http://dx.doi.org/10.3329/bjmm.v2i2.28846.

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The present study was to assess the pattern of antibiotic susceptibility of the isolated bacteria in an urban referral hospital in Dhaka City. A total of 393 bacterial strains were isolated from various specimens over a l0-months period. The majority of the organisms were Escherichia coli Q3.33oh) followed by Klebsiella species (27.480 ), Staphylococcas aureus (l7.Oioh),Lcinetobacter species (8.l4yo), Pseudomonas species (7.l2Yo), and others. The thirdgeneration Cephalosporins Hke Ceftriaxone, Ceftazidime and Cefotaxime were sensitive against 45-66yo isolated Enterobacteriaceae. The first- and second-generation Cephalosporins were less effective. The sensitivity to Ciprofloxacin of various Enterobacteriaceae was only between 33-4Oo compared to 52.8-67.9Vo against Gentamicin. Majority of the Enterobacteriaceae were resistant to Ampicillin, whereas almost all of the Enterobacteriaceae (94-100%o) were sensitive to Imipenem. Ahont97.UY;s Acinetobacter species were susceptible to Imipenem. Sensitivity of the organism (Acinetobacter) to third-generation Cephalosporins ranged between 50-560 , whereas 40.60/o were found sensitive to Ciprofloxacin. The sensitivity to Chloramphenicol, Co-trimoxazole, Cephalexin and Ampicillin ranged between 9.3oh to 34.30 . About 93.0%o of Pseudomonas species were sensitive to Imipenem. The rate of susceptibility to Gentamicin and Netilmicin was higher than those of the Ciprofloxacin and Ceftriaxone (67.80/o and, 53.57o vs, 39.2yo), About 707o of isolated S. aureus were resistant to OxacilHn but all were sensitive to Vancomycin. The result of this study would help the physicians to make a judicious choice of,.anti.biotics for therapeutic purposes.Bangladesh J Med Microbiol 2008; O2 (02):7-ll
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Kou, Kou, Xiang-Yu Hou, Jian-Dong Sun, and Kevin Chu. "Doctor’s Knowledge and Practices of Traumatic Brain Injury Management in Chinese Prehospital Settings." Prehospital and Disaster Medicine 30, no. 6 (October 22, 2015): 560–68. http://dx.doi.org/10.1017/s1049023x15005257.

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AbstractObjectivesThe incidence and mortality of traumatic brain injury (TBI) has increased rapidly in the last decade in China. Appropriate ambulance service can reduce case-fatality rates of TBI significantly. This study aimed to explore the factors (age, gender, education level, clinical experience, professional title, organization, specialty before prehospital care, and training frequency) that could influence prehospital doctors’ knowledge level and practices in TBI management in China, Hubei Province.MethodsA cross-sectional questionnaire survey was conducted in two cities in Hubei Province. The self-administered questionnaire consisted of demographic information and questions about prehospital TBI management. Independent samples t-test and one-way ANOVA were used to analyze group differences in the average scores in terms of demographic character. General linear regression was used to explore associated factors in prehospital TBI management.ResultsA total of 56 questionnaires were handed out and 52 (93%) were returned. Participants received the lowest scores in TBI treatment (0.64; SD=0.08) and the highest scores in TBI assessment (0.80; SD=0.14). According to the regression model, the education level was associated positively with the score of TBI identification (P=.019); participants who worked in the emergency department (ED; P=.011) or formerly practiced internal medicine (P=.009) tended to get lower scores in TBI assessment; participants’ scores in TBI treatment were associated positively with the training frequency (P=.011); and no statistically significant associated factor was found in the overall TBI management.ConclusionThis study described the current situation of prehospital TBI management. The prehospital doctors’ knowledge level and practices in TBI management were quantified and the influential factors hidden underneath were explored. The results indicated that an appropriate continuing medical education (CME) program enables improvement of the quality of ambulance service in China.KouK, HouXY, SunJD, ChuK. Doctor’s knowledge and practices of traumatic brain injury management in Chinese prehospital settings. Prehosp Disaster Med. 2015;30(6):560–568.
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Chhetri, U. D., I. Ansari, S. Bhandary, and N. Adhikari. "Sex Preferences Among Mothers Delivering at Patan Hospital." Kathmandu University Medical Journal 9, no. 4 (June 17, 2012): 229–32. http://dx.doi.org/10.3126/kumj.v9i4.6334.

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Background High sex ratios at birth (SRB) are seen in China, Taiwan, South Korea, parts of India and Vietnam. The imbalance is the result of son preference, accentuated by declining fertility. Prenatal sex determination and female feticides are common in many countries. It is reflected in sex ratio Objective To determine reasons for the preferences for different sex; to find out whether there is altered sex ratio at birth and to find out whether female feticide are common among women who had abortion. Method It is a prospective study. Women who had previous history of abortion and had delivered at Patan Hospital in the year 2066 were interviewed as per questionnaires. Results Among 560 women with total live births of 965, (462 male and 503 female) during their life time the overall sex ratio was 92 male per 100 female birth; total abortions were 663. Preferences for male were 10%, female 15.4% and either was for 74%. The reason for male preference was to continue family lineage, to bring honor, old age security, and performing funeral rites while the reasons for daughter preferences were that they understand mother’s pain, help in household work. The sex ratio of the babies born during the study period was 113 male per 100 female births. The Sex ratio at birth from 1st to 6th deliveries was 61, 79, 101, 210, 286 and 1100 male per 100 female birth respectively. Prenatal sex selection was 8% (by USG) but none had sex selected abortion. ConclusionSex ratio of those delivered during the study period was skewed (136 boys per 100 girls) towards male. There was shift in SRB in 4th and subsequent pregnancies in favor of boys. As the male sex ratio increased the number of induced abortion decreased in subsequent pregnancies.DOI: http://dx.doi.org/10.3126/kumj.v9i4.6334 Kathmandu Univ Med J 2011;9(4):229-232
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Statsenko, Yauhen, Fatmah Al Zahmi, Tetiana Habuza, Klaus Neidl-Van Gorkom, and Nazar Zaki. "Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance." BMJ Open 11, no. 2 (February 2021): e044500. http://dx.doi.org/10.1136/bmjopen-2020-044500.

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BackgroundDespite the necessity, there is no reliable biomarker to predict disease severity and prognosis of patients with COVID-19. The currently published prediction models are not fully applicable to clinical use.ObjectivesTo identify predictive biomarkers of COVID-19 severity and to justify their threshold values for the stratification of the risk of deterioration that would require transferring to the intensive care unit (ICU).MethodsThe study cohort (560 subjects) included all consecutive patients admitted to Dubai Mediclinic Parkview Hospital from February to May 2020 with COVID-19 confirmed by the PCR. The challenge of finding the cut-off thresholds was the unbalanced dataset (eg, the disproportion in the number of 72 patients admitted to ICU vs 488 non-severe cases). Therefore, we customised supervised machine learning (ML) algorithm in terms of threshold value used to predict worsening.ResultsWith the default thresholds returned by the ML estimator, the performance of the models was low. It was improved by setting the cut-off level to the 25th percentile for lymphocyte count and the 75th percentile for other features. The study justified the following threshold values of the laboratory tests done on admission: lymphocyte count <2.59×109/L, and the upper levels for total bilirubin 11.9 μmol/L, alanine aminotransferase 43 U/L, aspartate aminotransferase 32 U/L, D-dimer 0.7 mg/L, activated partial thromboplastin time (aPTT) 39.9 s, creatine kinase 247 U/L, C reactive protein (CRP) 14.3 mg/L, lactate dehydrogenase 246 U/L, troponin 0.037 ng/mL, ferritin 498 ng/mL and fibrinogen 446 mg/dL.ConclusionThe performance of the neural network trained with top valuable tests (aPTT, CRP and fibrinogen) is admissible (area under the curve (AUC) 0.86; 95% CI 0.486 to 0.884; p<0.001) and comparable with the model trained with all the tests (AUC 0.90; 95% CI 0.812 to 0.902; p<0.001). Free online tool at https://med-predict.com illustrates the study results.
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Polizzotto, Mark N., Thomas S. Uldrick, Victoria Wang, Karen Aleman, Kathleen M. Wyvill, Vickie Marshall, Stefania Pittaluga, et al. "Distinct Human and Viral Interleukin-6 Profiles and Other Viral and Immunologic Abnormalities In KSHV-Associated Multicentric Castleman Disease: Relationship with Disease Activity and Individual Disease Manifestations." Blood 118, no. 21 (November 18, 2011): 1573. http://dx.doi.org/10.1182/blood.v118.21.1573.1573.

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Abstract Abstract 1573 Background: Multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder characterized by flares of severe inflammatory symptoms, including fever and cachexia, with cytopenias and biochemical abnormalities. In the idiopathic form, its pathogenesis is linked to overproduction of interleukin (IL)-6. A distinct form of MCD is caused by Kaposi sarcoma-associated herpesvirus (KSHV, also called human herpesvirus [HHV]-8). KSHV encodes a viral homolog of IL-6, vIL-6, and this has been hypothesized to be central to KSHV-MCD pathogenesis. However, viral and human cytokines have not been examined together in KSHV-MCD, and their contribution to disease activity and symptoms is not known. Methods: Patients with pathologically-proven KSHV-MCD were enrolled on a prospective natural history study incorporating pilot evaluation of novel therapies (NCT00099073). Factors potentially important in pathogenesis were assayed at flare and complete clinical and laboratory remission: KSHV viral load (VL) in peripheral blood mononuclear cells, vIL-6, IL-1β, IL-5, human IL-6 (hIL-6), IL-8, IL-10, IL-12p70, IFN-γ and TNF-α. Paired analyses were performed for each patient comparing initial flare and remission. Associations between cytokines and individual disease manifestations were explored across all flares. Results: 21 patients had at least one flare for analysis (19 [90%] male; med age 44 [range 29–52]). 34 flares were observed (range 1–3 per patient) and followed to remission (20 patients) or death (1). All were HIV infected: CD4 med 252cells/μL (range 24–1319), HIV VL med <48 copies/mL (<48–64,100), 94% receiving antiretrovirals. Clinical symptoms included fever (present in 62%, med 38°C [range 36.1–40.5]); fatigue (91%, med CTC grade 2 [0–3]), gastrointestinal (GI) symptoms (68%, med grade 1 [0–3]) and respiratory symptoms (61%, med grade 1 [0–2]). Laboratory findings included anemia (97%, 9.9g/L [6.8–14.4]), thrombocytopenia (68%, 100×103cells/μL [6–567]), hypoalbuminemia (97%, 2.7g/L [1.2–3.9]) hyponatremia (68%, 133mEg/L [127–143]) and C-reactive protein (CRP) elevation (100%, 87.3g/L [6.3–339.5]). Factors elevated during initial flares were: KSHV VL (med 14,700/106 PBMCs [range 0–3,913,000] P <0.0001 compared with remission); vIL-6 (detected in 48%, <1560pg/mL [<1560-20,500] P= 0.0039); hIL-6 (15.9pg/mL [1.4-171.5] P= 0.0006); IL-10 (449pg/mL [2.8-85,900] P= 0.0007); TNF-α (29.0 pg/ml [7.9–90.8] P= 0.0083) and IL-1β (1.2 pg/ml [0.1–5.7] P= 0.0027). IL-5 was decreased compared with remission (0.6 [0.1–15.4] P= 0.016). Differences were most marked for vIL-6 (undetectable in all remissions), hIL-6 (med increase from remission 520%) and IL-10 (med increase from remission 5000%). KSHV VL was correlated with hIL-6 (R = 0.68, P= 0.001) and IL-10 (R=0.82, P= 0.001) across all flares and remissions; other correlations were weaker. There was also a strong association between KSHV VL and vIL-6 (P= 0.001 by Jonckheere-Terpstra). For hIL-6 and vIL-6 only, we observed distinct profiles across flares: vIL-6 elevation only (2 flares, 6%), hIL-6 only (17 flares, 50%), and hIL-6 with vIL-6 (13 flares, 38%). In 2 flares (6%), neither vIL-6 nor hIL-6 were detected at onset, but in both hIL-6 alone soon became elevated. In contrast, KSHV VL, IL-10, TNF-α and IL-1β were consistently elevated during flares. Compared with hIL-6-only flares, hIL-6 with vIL-6 flares exhibited significantly higher CRP (P =0.0009); worse hyponatremia (P =0.02); higher KSHV VL (P =0.016) and IL-10 (P= 0.012); and lower IL-5 (P= 0.009). In linear/logistic regression models of disease manifestations with cytokines, best predictors were: GI symptoms, respiratory symptoms, temperature, platelet count: hIL-6 alone; hemoglobin: hIL-6 and vIL-6; sodium: hIL-6, vIL-6 and IL-10; albumin: IL-1β and vIL-6. Conclusions: This prospective analysis shows for the first time that vIL-6 and hIL-6 can independently or together lead to flares of KSHV-MCD. It shows novel associations of KSHV-MCD flares with IL-1β and TNF-α elevation and IL-5 depression while confirming associations with KSHV VL and IL-10. It further suggests that vIL-6 and hIL-6 may jointly contribute to the severity of some symptoms during flares. As vIL-6 can signal independently of the ligand-binding IL-6 receptor-a, these findings have implications for the development of novel KSHV-MCD therapies targeting IL-6 and its downstream signaling. Disclosures: No relevant conflicts of interest to declare.
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Ruiz-Simón, S., I. Calabuig, M. Gomez-Garberi, and M. Andrés. "POS0141 ACTIVE SCREENING FOR GOUT IDENTIFIES A LARGER CARDIOVASCULAR POPULATION AT HIGH MORTALITY RISK." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 282.2–282. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1872.

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Background:We have recently revealed by active screening that about a third of gout cases in the cardiovascular population is not registered in records [1], highlighting the value of field studies.Objectives:To assess whether gout screening in patients hospitalized for cardiovascular events may also help identify patients at higher risk of mortality after discharge.Methods:A retrospective cohort field study, carried out in 266 patients admitted for cardiovascular events in the Cardiology, Neurology and Vascular Surgery units of a tertiary centre in Spain. The presence of gout was established by records review and face-to-face interview, according to the 2015 ACR/EULAR criteria. The occurrence of mortality during follow-up and its causes were obtained from electronic medical records. The association between gout and subsequent mortality was tested using Cox regression models. Whether covariates affect the gout-associated mortality was also studied.Results:Of 266 patients recruited at baseline, 17 were excluded due to loss to follow-up (>6mo), leaving a final sample of 249 patients (93.6%). Thirty-six cases (14.5% of the sample) were classified as having gout: twenty-three (63.9%) had a previously registered diagnosis, while 13 (36.1%) had not and was established by the interview.After discharge, the mean follow-up was 19.9 months (SD ±8.6), with a mortality incidence of 21.6 deaths per 100 patient-years, 34.2% by cardiovascular causes.Gout significantly increased the risk of subsequent all-cause mortality, with a hazard ratio (HR) of 2.01 (95%CI 1.13 to 3.58). When the analysis was restricted to gout patients with registered diagnosis, the association remained significant (HR 2.89; 95%CI 1.54 to 5.41).The adjusted HR for all-cause mortality associated with gout was 1.86 (95% CI 1.01-3.40). Regarding the causes of death, both cardiovascular and non-cardiovascular were numerically increased.Secondary variables rising the mortality risk in those with gout were age (HR 1.07; 1.01 to 1.13) and coexistent renal disease (HR 4.70; 1.31 to 16.84), while gender, gout characteristics and traditional risk factors showed no impact.Conclusion:Gout was confirmed an independent predictor of subsequent all-cause mortality in patients admitted for cardiovascular events. Active screening for gout allowed identifying a larger population at high mortality risk, which may help tailor optimal management to minimize the cardiovascular impact.References:[1]Calabuig I, et al. Front Med (Lausanne). 2020 Sep 29;7:560.Disclosure of Interests:Silvia Ruiz-Simón: None declared, Irene Calabuig: None declared, Miguel Gomez-Garberi: None declared, Mariano Andrés Speakers bureau: Grunenthal, Menarini, Consultant of: Grunenthal, Grant/research support from: Grunenthal
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記載無し. "Maximum likehood analysis of free-response receiver operating characteristic (FROC) data, Dev P. Chakraborty, Med. Phys., 16, (4), 561-568, (1989)." Japanese Journal of Radiological Technology 47, no. 4 (1991): 686–87. http://dx.doi.org/10.6009/jjrt.kj00003500172.

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Hang, Junjie, Feifei Wei, Zhiying Yan, Xianming Zhang, Kequn Xu, and Yingwei Zhu. "The value of miR-510 in the prognosis and development of colon cancer." Open Medicine 16, no. 1 (January 1, 2021): 795–804. http://dx.doi.org/10.1515/med-2021-0251.

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Abstract Purpose Colon cancer is one of the malignant tumors that threatens human health. miR-510 was demonstrated to play roles in the progression of various cancers; its dysregulation was speculated to be associated with the development of colon cancer. Methods One hundred and thirteen colon cancer patients participated in this research. With the help of RT-qPCR, the expression of miR-510 in collected tissues and cultured cells was analyzed. The association between miR-510 expression level and clinical features and prognosis of patients was evaluated. Moreover, the effects of miR-510 on cell proliferation, migration, and invasion of colon cancer were assessed by CCK8 and Transwell assay. Results miR-510 significantly upregulated in colon cancer tissues and cell lines relative to the adjacent normal tissues and colonic cells. The expression of miR-510 was significantly associated with the TNM stage and poor prognosis of patients, indicating miR-510 was involved in the disease progression and clinical prognosis of colon cancer. Additionally, the upregulation of miR-510 significantly promoted cell proliferation, migration, and invasion of colon cancer, while its knockdown significantly inhibited these cellular processes. SRCIN 1 was the direct target of miR-510 during its promoted effect on the development of colon cancer. Conclusion The upregulation of miR-510 acts as an independent prognostic indicator and a tumor promoter by targeting SRCIN 1 in colon cancer, which provides novel therapeutic strategies for colon cancer.
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Bruce, Scott G. "The Routledge History of Medieval Magic, ed. Sophie Page and Catherine Rider. London and New York: Routledge, 2019, 550 pp." Mediaevistik 33, no. 1 (January 1, 2020): 347–49. http://dx.doi.org/10.3726/med.2020.01.62.

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Dou, Nan, Evaniya Shakya, Raphia Ngoutane, Roger Sodjinou, Christine Kaligirwa, Anne-Sophie Le Dain, Aashima Garg, et al. "Trends and Influencing Factors of Complementary Feeding Practices in Niger: An Analysis of National Surveys From 2000 – 2018." Current Developments in Nutrition 5, Supplement_2 (June 2021): 639. http://dx.doi.org/10.1093/cdn/nzab045_021.

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Abstract Objectives To examine the trends and influencing factors of suboptimal complementary feeding (CF) practices among children aged 6–23 months in Niger using national data from 2000 to 2018. Methods Using data from the 2000 Multiple Indicator Cluster Survey, 2012 Demographic and Health Surveys (DHS), and 2018 Standardized Monitoring and Assessment of Relief and Transitions survey in Niger, the trends and predictors of WHO-UNICEF CF indicators including timely introduction of complementary foods (INTRO), minimum meal frequency (MMF), minimum dietary diversity (MDD), and minimum acceptable diet (MAD) were estimated. Using the most completed data in CF and influencing factors (available from 2012 DHS), multilevel logistic regression models were applied to identify factors at the individual, household and community levels that were associated with meeting INTRO, MMF, MDD, and MAD. Results The weighted proportion of children aged 6–8 months meeting INTRO increased from 56.0% in 2000 to 84.4% in 2018. The weighted proportion of children meeting MMF (51.3% to 77.9%), MDD (9.8% to 14.2%), and MAD (5.6% to 10.9%) also increased between 2012 - 2018. At the individual level, children with mothers who were employed had higher odds of meeting all four indicators as compared to those whose mothers were unemployed. Older child age and maternal exposure to media were significantly associated with higher odds of meeting MMF, MDD, and MAD. Maternal education and child birth weight greater or smaller than average (reference) were positively associated with the odds of meeting MMF and MAD, and antenatal iron supplementation and currently breastfeeding were positively associated with the odds of achieving MDD and MAD. At the household level, the odds of meeting MMD and MAD were higher among children from wealthier households. At the community level, the odds of meeting INTRO and MMF were higher among children from communities with greater access to health services. Conclusions Despite the improvement in CF practices since 2000, only 10% of children from 6–23 months received minimum acceptable diets. Factors associated with CF were distributed across individual, household and community levels, suggesting the need for multi-level strategies to improve child nutrition in Niger. Funding Sources UNICEF West and Central Africa Regional Office (Grant # 43279190).
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Munden, Juliet Hilary. "Challenges and possibilities in educating EFL reading teachers." Acta Didactica Norge 12, no. 2 (June 12, 2018): 6. http://dx.doi.org/10.5617/adno.5610.

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AbstractExperiencing literature is part of the English as a foreign language (EFL) subject in Norway. It is both challenging and possible to educate competent reading teachers who can foster this experience. The present article is a thematic exploration of some of these challenges and possibilities. The challenges are discussed under four headings: the profession of the teacher educator; the complaint that student teachers do not read enough; the role of national tests in forming how reading in English is taught in school; and the challenge of making sense of the concept of reading strategies. The second part of the article considers possibilities. These are grounded in the principle that teacher educators should not primarily lecture. Instead, they should alternate systematically between enactment and metacognition. The article describes scenarios in which students try out a sequence of pre-, during- and post-reading activities related to the short story “The Demon Lover” by Elizabeth Bowen. After engaging with each activity, the students take part in a reflection led by the teacher educator on their experience as readers, the learning potential of the activity, and questions related to its adaptation and organisation in a diverse school classroom. This operationalisation of a pedagogy of enactment (Grossman et al., 2009) allows student teachers to gain experience of and reflect on core practices. In the present case, the core practice is the planning and teaching of coherent and motivating learning sequences that promote increased reading motivation and proficiency in the English language classroom.Keywords: teacher education, subject English, reading strategies, learning sequence, metacognitionUtfordringer og muligheter i utdanningen av leselærere i engelskfagetSammendragLitteraturopplevelser hører til i engelskfaget i norsk skole. Det er både ut-fordrende og mulig å utdanne kompetente leselærere som kan fremme slike opplevelser. Denne artikkelen er en tematisk utforskning av noen av disse utfordringene og mulighetene. Utfordringene diskuteres under fire overskrifter: lærerutdanneren som profesjonsutøver; misnøyen med at studenter ikke leser nok; betydningen av nasjonale prøver for hvordan lesing i engelsk er undervist i skolen; og utfordringen med å forstå lesestrategier som konsept. Den andre delen av artikkelen tar for seg mulighetene som ligger i prinsippet om at lærer-utdannere ikke primært skal forelese. Isteden bør de veksle systematisk mellom utøvelse og metakognisjon. Artikkelen beskriver en sekvens hvor studenter prøver ut før-, under- og etter-lesningsaktiviteter tilknyttet Elizabeth Bowens novelle “The Demon Lover”. Etter å ha engasjert seg i hver aktivitet, deltar studentene i en refleksjon ledet av lærerutdanneren, hvor de drøfter sine opplevelser som lesere, aktivitetens læringspotensial, og spørsmål om tilpasning og organisering av aktiviteten i et mangfoldig klasserom. Denne operasjonaliseringen av en enactment-pedagogikk (Grossman et al., 2009) gir lærerstudenter anledning til å skaffe seg erfaring med og reflektere over kjerne-praksiser. I dette tilfellet er kjernepraksisen det å planlegge koherente og moti-verende læringssekvenser som fører til økt lesemotivasjon og kompetanse i det engelske klasserommet.Nøkkelord: lærerutdanning, engelskfaget, lesestrategier, læringsøkt, metakogni¬sjon
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Clason, Christopher R. "Stephanie Cain Van D’Elden. Tristan and Isolde: Medieval Illustrations of the Verse Romances. Turnhout, Belgium: Brepols, 2016. 462 pp., 538 Ill." Mediaevistik 32, no. 1 (January 1, 2020): 332–33. http://dx.doi.org/10.3726/med.2019.01.51.

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Stephanie Cain Van D’Elden’s prodigious volume on illustrations of the Tristan materials fills a gap in research on the Tristan illustrations by providing a single, authoritative resource for them. As the author explains, its purpose is quite simply “to list all the extant manuscripts, artefacts, and objets d’art, and to describe all the scenes depicted on them” (3). Building upon previous studies of illustrations by literary critics and art historians over the past century, including works by Hella Frühmorgen-Voss, Norbert H. Ott, and Robert Sherman and Laura Hibbard Loomis, as well as the exhibition of Arthurian art and literature in Leuven at the XVth Congress of the International Arthurian Society in 1987, Van D’Elden collected over 500 images from the broad span of Tristan sources, identifying them according to the manuscripts or objects which they adorn, as well as categorizing them by the specific scenes in the Tristan materials they depict. Van D’Elden’s efforts to organize and catalogue over 500 items, reproduced clearly and cleanly in fine detail, will serve as a valuable contribution for decades to come to our cross-disciplinary understanding of Tristan, one of the most important tales of the European Middle Ages.
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KIM, Sunghwan. "LET Calibration of Fe 500 MeV/u Ions using SSNTD." Journal of Sensor Science and Technology 25, no. 1 (January 31, 2016): 41–45. http://dx.doi.org/10.5369/jsst.2016.25.1.41.

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Svendsen, Erik Nordahl. "TV-sening i 1988-91 - konkurrencen om seerne." MedieKultur: Journal of media and communication research 8, no. 17 (August 29, 1992): 6. http://dx.doi.org/10.7146/mediekultur.v8i17.910.

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Hvad er der sket med danskernes TV-sening i de år, hvor de har haft adgang til 2 danske TV-kanaler? Eller sagt med andre ord, hvordan har konkurrencen om seerne udviklet sig? Siden oktober 1988, da TV2 begyndte, har DR og TV2 samarbejdet om indsamlingen af daglige oplysninger om TV-forbruget. Derfor er det muligt at få et overblik over, hvor mange seere den enkelte kanal dagligt er i kontakt med (dækningen), hvor lang tid befolkningen i gennemsnit bruger på kanalen (seertiden) og hver enkelt kanals andel af den samlede seer- tid. Alle seertal er hentet fra AIMs interviewundersøgelser af 500 personer. Fra 1.1.1992 er TV-selskaberne gået over til at anvende AGB Gallerups elektroniske TV-Meters (panel på 500 husstande med ca. 1200 personer). De foreliggende testdata fra december 1991 viser mindre forskelle mellem DR og TV2 end AIM-tallene i artiklen. Nedenstående artikel er også trykt i "Medieforskning i Danmarks Radio 1990".
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Classen, Albrecht. "Walter Pohl, The Avars: A Steppe Empire in Central Europe, 567–822. Ithaca, NY, and London: Cornell University Press, 2018, xxiii, 636 pp., 4 maps." Mediaevistik 32, no. 1 (January 1, 2020): 381–82. http://dx.doi.org/10.3726/med.2019.01.75.

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Even though this is not a new publication, Pohl’s study on the Avars deserves particular attention, now in its first English translation. While not identified on the cover page, Pohl’s book was superbly translated into English by Will Sayers, who is briefly mentioned in the preface. Pohl had published his book originally in German in 1988, and it appeared in its third edition in 2015. Only in the last few decades has our awareness and understanding of the Avars grown and changed, particularly because intensive archaeological evidence has vastly changed our concept of that Steppe people who lived in the Carpathian Basin long before the Magyars settled there. Consequently, Pohl has made great efforts to reflect on the new insights and rewrote the respective sections of this book. In short, although here we hold in our hands ‘only’ the English translation of the third edition, The Avars represents, after all, a new approach and a thorough update of the current research on that people that had significant influence on the Byzantines, the Germanic peoples to the west and southwest, and to the north and east. They were the first to introduce into Europe the stirrup, but they left practically no written sources. They were Nomadic people, and yet not simply barbarians, as later chroniclers liked to call them. Hence, Pohl’s study on this early medieval people sheds important light on the political and military structure of early medieval Europe in an area where the Byzantine sphere of interest ended and where the Carolingians endeavored to place their stakes.
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Sinar, Beck. "Promoting metalinguistic awareness in a classroom to improve reading comprehension: Examples from Roald Dahl’s novel The BFG." Acta Didactica Norge 12, no. 2 (June 4, 2018): 11. http://dx.doi.org/10.5617/adno.5605.

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It is widely recognised that successful reading involves the interaction of a number of different cognitive skills and strategies in order to achieve compre-hension of the text (Baker, 2002). These skills and strategies are generally considered to be controlled by a global process called ‘metacognition’ (Kuhn & Dean, 2004). In this paper, I suggest that a large part of metacognition when reading has a (meta)linguistic component and hence time should be devoted to raising (meta)linguistic awareness when teaching and honing reading skills and strategies. Tasks based around a short extract from Roald Dahl’s (1982[2013]) novel The BFG are presented and discussed in order to illustrate how metalinguistic awareness might be raised in a classroom. Such tasks not only help to improve reading comprehension but have a number of additional benefits: they enhance and support the metacognitive toolkit, improve vocabulary acquisition and growth, and can bring a love of language and the fun of language play into the classroom.Keywords: metalinguistic awareness, reading comprehension, vocabulary, classroom activities, Roald DahlÅ fremme metalingvistisk bevissthet i et klasserom for å forbedre leseforståelse: eksempler fra Roald Dahls roman The BFGSammendragDet er bred enighet om at vellykket lesing trekker veksler på flere forskjellige kognitive ferdigheter og strategier tilknyttet tekstforståelse (Baker, 2002). Disse ferdighetene og strategiene hører inn under den globale prosessen ‘metakog-nisjon’ (Kuhn & Dean, 2004). I denne artikkelen argumenterer jeg for at en stor del av metakognisjonen i lesing har en (meta)lingvistisk komponent, og følgelig at tid bør vies til å utvikle (meta)lingvistisk bevissthet i undervisningen av leseferdigheter og strategier. Arbeidsoppaver basert på et kort utdrag fra Roald Dahls (1982[2013]) The BFG (The Big Friendly Giant / SVK – Store Vennlige Kjempe) presenteres og diskuteres for å illustrere hvordan metalingvistisk bevissthet kan utvikles i klasserommet. Slike arbeidsoppgaver hjelper ikke bare med å forbedre leseforståelsen, men har også flere andre fordeler: de forsterker og støtter den metakognitive verktøykassen, forbedrer både innlæring og utvidelse av ordforrådet, kan øke språkgleden og oppmuntre til lek med språk i klasserommet.Nøkkelord: metalingvistisk bevissthet, leseforståelse, vokabular, klasseroms-aktiviteter, Roald Dahl
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Ponte, José. "Resposta a um Comentário do Prof. Henrique Carmona da Mota Sobre o Artigo Publicado em Acta Med Port 2019 Sep;32(9):565–567." Acta Médica Portuguesa 33, no. 4 (April 1, 2020): 291. http://dx.doi.org/10.20344/amp.13518.

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Zhao, Juan, Xue-Bin Zeng, Hong-Yan Zhang, Jie-Wei Xiang, and Yu-Song Liu. "Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p." Open Medicine 15, no. 1 (September 30, 2020): 921–31. http://dx.doi.org/10.1515/med-2020-0175.

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AbstractLong non-coding RNA forkhead box D2 adjacent opposite strand RNA 1 (FOXD2-AS1) has emerged as a potential oncogene in several tumors. However, its biological function and potential regulatory mechanism in glioma have not been fully investigated to date. In the present study, RT-qPCR was conducted to detect the levels of FOXD2-AS1 and microRNA (miR)-506-5p, and western blot assays were performed to measure the expression of CDK2, cyclinE1, P21, matrix metalloproteinase (MMP)7, MMP9, N-cadherin, E-cadherin and vimentin in glioma cells. A luciferase reporter assay was performed to verify the direct targeting of miR-506-5p by FOXD2-AS1. Subsequently, cell viability was analyzed using the CCK-8 assay. Cell migration and invasion were analyzed using Transwell and wound healing assays, respectively. The results demonstrated that FOXD2-AS1 was significantly overexpressed in glioma cells, particularly in U251 cells. Knockdown of FOXD2-AS1 in glioma cells significantly inhibited cell proliferation, migration, invasion and epithelial–mesenchymal transition (EMT) and regulated the expression of CDK2, cyclinE1, P21, MMP7 and MMP9. Next, a possible mechanism for these results was explored, and it was observed that FOXD2-AS1 binds to and negatively regulates miR-506-5p, which is known to be a tumor-suppressor gene in certain human cancer types. Furthermore, overexpression of miR-506-5p significantly inhibited cell proliferation, migration, invasion and EMT, and these effects could be reversed by transfecting FOXD2-AS1 into the cells. In conclusion, our data suggested that FOXD2-AS1 contributed to glioma proliferation, metastasis and EMT via competitively binding to miR-506-5p. FOXD2-AS1 may be a promising target for therapy in patients with glioma.
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Classen, Albrecht. "Wolfram von Eschenbach, Parzival. Bd. 1: Text nach der Handschrift D als “Leithandschrift”. Band 2: Untersuchungen. Hrsg. von Hermann Reichert. Wien: Praesens Verlag, 2018, 520, 397 S." Mediaevistik 32, no. 1 (January 1, 2020): 445–46. http://dx.doi.org/10.3726/med.2019.01.110.

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Mit etwas Verwunderung, oder schlicht tief beeindruckt nimmt man diese neue Edition zusammen mit ihrer ausführlichen Kommentierung in die Hand, ein zweibändiges Werk, in dem Wolframs von Eschenbach Parzival in einem Mammutverfahren nach der Handschrift D, heute in der Stiftsbibliothek von St. Gallen (Cod. 857) aufbewahrt, neu herausgegeben wird. Ihre Beschreibung findet sich im 2. Band, S. 18–22, worauf dann die Beschreibungen aller anderen Handschriften folgen, die den Parzival enthalten, was für sich genommen schon eine erstaunliche Leistung darstellt. Reichert geht hier weit über den Wissensstand hinaus, der online im Marburger Repetorium geboten wird (<ext-link ext-link-type="uri" xlink:href="http://www.handschriftencensus.de/werke/440">http://www.handschriftencensus.de/werke/440</ext-link>), insoweit als er detailliert die Angaben über den entsprechenden Textbestand vom Parzival liefert, wogegen er die historischen Informationen zu den Handschriften weitgehend weglässt, die man aber, wie gesagt, online finden kann.
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Lemont, Harvey, and Marc Sabo. "Terbinafine-Associated Taste Disturbance with Normal Taste Threshold Scores." Journal of the American Podiatric Medical Association 91, no. 10 (November 1, 2001): 540–41. http://dx.doi.org/10.7547/87507315-91-10-540.

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The medical literature reveals numerous reports of transient taste disturbance associated with the use of oral terbinafine. A review of these reports, however, fails to confirm taste disturbances by formal taste testing. In this article, a case of long-standing taste dysfunction in a patient who exhibited normal formal taste thresholds is described. (J Am Podiatr Med Assoc 91(10): 540-541, 2001)
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Dickler, M. N., T. Traina, K. Panageas, R. Steingart, C. Dang, M. Fornier, S. Sugarman, L. Norton, C. Hudis, and H. Rugo. "Adjuvant (adj) bevacizumab (B) plus dose-dense (dd) doxorubicin/cyclophosphamide (AC) followed by nanoparticle albumin- bound paclitaxel (nab-p) in early stage breast cancer (BC) patients (pts): Cardiac safety." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 567. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.567.

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567 Background: Dose dense, q2 wk AC-paclitaxel (T) is superior to q3 wk therapy (Rx) (Citron, JCO 2003). The risk of congestive heart failure (CHF) with ddAC-T is not increased at <1%. In MBC, B improves PFS when added to T (Miller, SABCS 2005). It is unclear if doxorubicin plus B increases risk of CHF. Hence, we are testing the cardiac safety of ddAC-nab-p with concurrent B as adj therapy. Based upon the accepted cardiac event (CE) rate of ≤4% in trials with adj trastuzumab (an agent with known cardiac toxicity), we designed this study with similar monitoring & tolerability thresholds. The primary endpoint is cardiac safety, defined as discontinuation of B due to cardiac death from LV dysfunction or symptomatic CHF (dyspnea and LVEF<50%). Secondary endpoints: toxicity, disease-free & overall survival. Methods: Eligible pts have resected HER2(-) BC and normal LVEF. Rx consists of q2wk AC (60/600 mg/m2) ×4 then nab-p (260 mg/m2) x4 with pegfilgrastim on Day 2 plus B for one year (10mg/kg IV q2wk ×8 with chemoRx then B 15mg/kg q3wk); radiation & endocrine Rx per standard of care. MUGA obtained at baseline & mos. 2, 6, 9, 18. Pts with significant asymptomatic ↓LVEF during Rx may have B held per protocol. These pts are not counted as CEs but will have long-term cardiac monitoring. Accrual goal is 75 pts. If ≥3 CE (∼4.7%) or >1 cardiac death from LV dysfunction, B + ddAC-nab-p will not be considered safe. Results: 44 pts have enrolled, median (med) age 46.5 yrs (33–67). 28 pts have baseline & month 2 LVEF data: med baseline LVEF 68% (61–82), med LVEF at mo. 2 after ddAC+B 68% (53–75); 1 pt had an 18 point asymptomatic drop to 53% - B held but reinitiated in 4 wks with repeat LVEF 63%. 12 pts completed nab-p+B but none have reached the 6 mo. MUGA. Rx-related Gr 3/4 toxicity: neutropenia gr4 (6.8%), diarrhea gr3 (2.3%), hypertension gr3 (2.3%), neuropathy gr 3 (2.3%), fatigue gr 3 (2.3%), mucositis gr 3 (2.3%). 4 pts have withdrawn from study Rx, but only 1 due to toxicity including gr3 fatigue, mucositis & neuropathy. Conclusions: No LV dysfunction has been observed with B + ddAC-nab-p; this trial is on-going. Long-term follow-up and analysis of troponin, renin and circulating endothelial & tumor cells are planned. No significant financial relationships to disclose.
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Bruce, Scott G. "nr="530"The Deeds of the Abbots of St. Albans: Gesta Abbatum Monasterii Sancti Albini, trans. David Preest and ed. James G. Clark. Woodbridge: Boydell Press, 2019, 990 pp." Mediaevistik 33, no. 1 (January 1, 2020): 530–31. http://dx.doi.org/10.3726/med.2020.01.152.

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Widmer, A. X., K. Wrenner, H. A. Ainspan, B. Parker, P. Austruy, B. Brezzo, A. M. Haen, et al. "Single-chip 4×500-MBd CMOS transceiver." IEEE Journal of Solid-State Circuits 31, no. 12 (1996): 2004–14. http://dx.doi.org/10.1109/4.545824.

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Alfie, Fabian. "nr="520"Jennifer N. Brown, Fruit of the Orchard: Reading Catherine of Siena in Late Medieval and Early Modern England. Toronto, Buffalo, and London: University of Toronto Press, 2019, pp. 313." Mediaevistik 33, no. 1 (January 1, 2020): 520–21. http://dx.doi.org/10.3726/med.2020.01.147.

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Bruce, Scott G. "Appendix Ovidiana: Latin Poems Ascribed to Ovid in the Middle Ages, ed. Ralph Hexter, Laura Pfuntner, and Justin Haynes. Dumbarton Oaks Medieval Library, 62. Cambridge, MA: Harvard University Press, 2020, 510 pp." Mediaevistik 33, no. 1 (January 1, 2020): 415–16. http://dx.doi.org/10.3726/med.2020.01.93.

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Shea, J. J. "Low dielectric constant materials, vol. 565 [Book Review]." IEEE Electrical Insulation Magazine 16, no. 6 (November 2000): 42. http://dx.doi.org/10.1109/mei.2000.887602.

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Karadeniz, H., E. Cingil, H. Satiş, A. Avanoğlu Güler, R. Bilici Salman, N. Atas, H. Babaoglu, et al. "FRI0109 TEMPORAL CHANGES IN LUNG NODULES DETECTED IN INDIVIDUALS WITH RHEUMATOID ARTHRITIS WITH BIOLOGIC DMARD TREATMENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 634.2–635. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3792.

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Background:Lung nodules in rheumatoid arthritis (RA), patients impose diagnostic and therapeutic challenges due to unpredictable outcome of these nodules. biologic (b) disease-modifying anti-rheumatic drugs (bDMARDs) are important therapeutic agents used in treatment of RA. There is hesitation about use of conventional synthetic DMARDs (csDMARD) and bDMARDs due to increased risk of nodules although their association remains unclear. There are scarce data on lung nodules observed in RA patients and systematic studies are needed.Objectives:The aim of this study is to evaluate effects of biologic treatments and conventional synthetic DMARDS on pulmonary nodules observed in rheumatoid arthritis patients.Methods:Electronic health records of RA patients who had had thorax computed tomography (CT) confirmed lung nodules in the last 5 years were retrospectively evaluated. Pre-treatment and post-treatment follow up CT images were meticulously examined for the number, size, attenuation, calcification, and cavitary formation. Demographic features, smoking status, disease characteristics and used medications were retrieved from file records. Clinical and laboratory findings, demographic features, treatment and follow-up duration, number of solid and cavitary nodules were compared between groups.Results:There were 21 patients in both biologic (11 females, mean age; 59.7±8.4) and csDMARD (12 females, mean age; 71.4±8.3) treated groups. There was no difference in frequency of nodule types and sizes between csDMARD and bDMARDs groups(table) despite csDMARD users were remarkably older. Administered biologic treatments were anti-TNF-alpha in 8, tofacitinib in 7, rituximab in 4, and abatacept in 2 patients. The most common types of nodules were solid and cavitary nodules, observed in 17 and 8 patients, respectively in biologic users. Calcific nodules were present in three patients, and ground glass nodules were observed in a single patient. Nodules were multiple in 12 patients and solitary in 9 patients. Calcific and ground glass nodules were all solitary in our study. Cavitary and solid nodules were concurrent in five patients. Median follow duration was 14(5-55) months. Progression was observed in small number of patients; three patients in receiving aTNFα, and one in rituximab(figure) and one in abatacept users. Interestingly none of patients receiving tofacitinib did not show progression. There was no difference regarding number of patients who progressed with either csDMARD or bDMARDs. None of the nodules showed malignant transformation within the observation period.Conclusion:In conclusion, risk of progression in lung nodules with biologic treatments is seem to be low, at least not more than csDMARD in short term and any malignant transformation was not observed in our study.References:[1]Esposito AJ, Chu SG, Madan R, Doyle TJ, Dellaripa PF. Thoracic Manifestations of Rheumatoid Arthritis. Clin Chest Med. 2019 Sep;40(3):545-560. doi:10.1016/j.ccm.2019.05.003. Epub 2019 Jul 6. Review. PubMed PMID: 31376890.Table.Changes in nodule characteristics with respect to treatment groups.csDMARDbDMARDsSOLID NODULESPre-treatmentTotal number of nodules, n7254Post-treatmentCompletely diminished, n514Regressed, n512Stable, n3320Enlarged, n234Cavitary transformation64De novo solid nodules267CAVITARY NODULESPre-treatmentTotal number of nodules1016Post-treatmentCompletely diminished, n01Regressed05Stable48Enlarged, n62Newly formed cavitary nodules69***number less than calculated due to cavitation,**de novo 5 nodules, 4 transformation from solid nodulesFigure.Nodule progression in a patient receiving rituximab (white arrow)Disclosure of Interests:None declared
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40

Huang, Li, Yuemin Kuang, Zhiyong Jiang, Yan Zhu, Xinguo Luo, Fangjing Shi, Shanshan Hu, and Xinfang Gao. "Thalidomide-induced serious RR interval prolongation (longest interval >5.0 s) in multiple myeloma patient with rectal cancer: A case report." Open Medicine 15, no. 1 (June 11, 2020): 540–44. http://dx.doi.org/10.1515/med-2020-0136.

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AbstractPrimary secondary tumor increased recently with the use of immunomodulatory drugs in patients with multiple myeloma (MM). However, MM with prior diagnosis of primary secondary tumor is relatively rare. In this study, we reported an MM patient with prior diagnosis of rectal cancer. In brief, an 85-year-old man was first diagnosed with rectal cancer. Given the age, heart failure and small-cell hypochromic anemia (hemoglobin level: 54 g/L), rectal cancer resection was not advised and symptomatic treatments were performed (including sufficient iron supplementation). Eight months later, the patient was diagnosed with MM due to worsening anemia. Anemia and heart failure were corrected after three cycles of treatment with thalidomide, dexamethasone and capecitabine. Radical resection of rectal carcinoma (Hartmann) was finally performed due to acute abdominal distension. Meanwhile, RR interval prolongation (longest interval >5.0 s) and atrial fibrillation occurred in the fifth cycle treatment. One month after discontinuation of thalidomide, RR interval returned to normal range, while atrial fibrillation developed into persistent atrial fibrillation.
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41

Classen, Albrecht. "Milvia Bollati, Flora Cassen, and Marc Michael Epstein, The Lombard Haggadah. Introduction by Christopher de Hamel. Ed. Sandra Hindman. Les Eluminures. New York: Paul Holberton, 2019, 239 pp., colored ill." Mediaevistik 32, no. 1 (January 1, 2020): 509–11. http://dx.doi.org/10.3726/med.2019.01.144.

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Those of us who work with medieval illustrated manuscripts are often guilty of ignoring the major contributions by medieval Jewish scribes and illuminators or the manuscripts produced for Jewish consumers. To remedy this situation, Milivia Bollati, Flora Cassen, and Marc Michael Epstein here present the most impressive Lombard Haggadah, both by examining its background, purpose, design, and by providing a complete facsimile of the manuscript. Famous Christopher de Hamel (Cambridge) adds a pleasant introduction in which he emphasizes the considerable degree of overlap of Christian and Jewish manuscript production. The Lombard Haggadah is the earliest stand-alone Haggadah and is one of only three illustrated medieval Haggadot still privately owned (Sandra Hindman, 8). This manuscript was on public display in New York in April 2019, and was for sale. <?page nr="510"?>It is not clear to me whether any buyer acquired it.
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42

Classen, Albrecht. "Anselm Rau, Das Model Franziskus: Bildstruktur und Affektsteuerung in monastischer Meditations- und Gebetspraxis. Neue Frankfurter Forschungen zur Kunst, 22. Berlin: Gebr. Mann Verlag, 2019, 566 pp., 141 s/w Abb. und 24 farbige Tafeln." Mediaevistik 32, no. 1 (January 1, 2020): 534–36. http://dx.doi.org/10.3726/med.2019.01.157.

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In dieser mächtigen Arbeit, die sich auf seine in Frankfurt eingereichte Dissertation von 2016, verteidigt im Mai 2017, stützt, geht es Anselm Rau darum nachzuweisen, welche Affektsteuerungen in Abbildungen des Hl. Franziskus von Assisi im Laufe der Zeit zum Ausdruck gekommen sind. Man muss dies genau im Auge behalten, um nicht durch die letztlich gar nicht so sehr auf den Heiligen bezogene Untersuchung in Verwirrung gebracht zu werden. Rau will also nicht <?page nr="535"?>noch eine spezielle Arbeit zu Franziskus vorlegen, was fast schon Eulen nach Athen zu tragen gleichkäme. Stattdessen möchte er herausfinden, welche modellhaften Strategien und Methoden aus dem Vorbild dieses Heiligen für die monastische Kommentar- und Meditationstradition entstanden (15), die zunehmend emotionsgetragen auftrat.
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43

Mogi, Iwao, and Kazuo Watanabe. "Chiral Recognition of Amino Acids by Magnetoelectrodeposited Cu Film Electrodes." International Journal of Electrochemistry 2011 (2011): 1–6. http://dx.doi.org/10.4061/2011/239637.

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Chiral behavior of magnetoelectrodeposited (MED) Cu film electrodes was investigated for the electrochemical reactions of amino acids. The Cu films were electrodeposited under a magnetic field of 5 T perpendicular to the electrode surface. Such MED Cu films were employed as an electrode, and cyclic voltammograms were measured for the electrochemical reactions of several kinds of amino acids. Chiral behavior was clearly observed as oxidation current difference between the enantiomers of alanine, aspartic acid, and glutamic acid. The MED film electrodes with the thickness of 50~500 nm exhibited such chiral behavior, and their surface morphologies had network structures, which could be induced by the micro-MHD effect.
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44

Classen, Albrecht. "The Cambridge World History of Violence. Vol. II: 500-1500 CE, ed. Matthew S. Gordon, Richard W. Kaeuper, and Harriet Zurndorfer. Cambridge: Cambridge University Press. 2020, xiv, 708 pp., 34 b/w ill, 1 table." Mediaevistik 33, no. 1 (January 1, 2020): 260–62. http://dx.doi.org/10.3726/med.2020.01.20.

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45

Shea, J. J. "Electrically based microstructural characterization II, volume 500 [Book Reviews]." IEEE Electrical Insulation Magazine 16, no. 1 (January 2000): 72–73. http://dx.doi.org/10.1109/mei.2000.817423.

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Shea, J. J. "Microstructural processes in irradiated materials, vol. 540 [Book Reviews]." IEEE Electrical Insulation Magazine 17, no. 1 (January 2001): 44. http://dx.doi.org/10.1109/mei.2001.901620.

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47

Kokhuis, Tom J. A., Valeria Garbin, Klazina Kooiman, Benno A. Naaijkens, Lynda J. M. Juffermans, Otto Kamp, Antonius F. W. van der Steen, Michel Versluis, and Nico de Jong. "Corrigendum to “Secondary Bjerknes Forces Deform Targeted Microbubbles” (Ultrasound Med Biol 2013;39:490–506)." Ultrasound in Medicine & Biology 47, no. 6 (June 2021): 1639. http://dx.doi.org/10.1016/j.ultrasmedbio.2021.02.010.

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48

McMahon, Aisling, Gabor Zilahi, and Enda O'Connor. "Intensive care microbiology pearls: learning by 1-500-5-1." Medical Education 51, no. 5 (March 14, 2017): 541–42. http://dx.doi.org/10.1111/medu.13289.

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49

Cetinkaya, Sinan, and Melih Basaraner. "Characterisation of building alignments with new measures using C4.5 decision tree algorithm." Geodetski vestnik 58, no. 03 (2014): 552–67. http://dx.doi.org/10.15292/geodetski-vestnik.2014.03.552-567.

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50

Classen, Albrecht. "Formen der Selbstthematisierung in der vormodernen Lyrik. Hrsg. von Dorothea Klein in Verbindung mit Thomas Baier, Brigitte Burrichter, Michael Erler und Isabel Karremann. Spolia Berolinensia: Beiträge zur Literatur- und Kulturgeschichte des Mittelalters und der Neuzeit, 39. Hildesheim: Weidmannsche Verlagsbuchhandlung, 2020, IX, 510 S." Mediaevistik 33, no. 1 (January 1, 2020): 314–16. http://dx.doi.org/10.3726/med.2020.01.46.

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