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Dissertations / Theses on the topic 'Mediated activity'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Fontaine, Frédéric. "APOL-Mediated trypanolytic activity." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209246.

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Apolipoprotein L1 (APOL1) is a human-specific serum protein bound to high-density lipoprotein (HDL) particles. This protein allows human resistance to infection by African trypanosomes except for two subspecies, Trypanosoma brucei rhodesiense and T. b. gambiense, the causative agents of sleeping sickness or African trypanosomiasis. This disease infects 20 000 people in sub-Saharan Africa and without treatment, infection is almost always fatal. T. b. rhodesiense resists APOL1 through direct protein neutralization by the Serum Resistance-Associated (SRA) protein. T. b. gambiense does not express

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2

Petoukhov, Eugenia. "Activity-mediated secretion of progranulin-containing granules." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43133.

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Progranulin (PGRN) is a multi-functional, secreted growth factor expressed in a variety of tissues throughout the body. In the central nervous system (CNS), PGRN is expressed in microglia as well as in a number of neuronal populations and has been shown to promote neuronal survival, enhance neurite outgrowth and regulate inflammation and development. Mutations in the progranulin (GRN) gene have been identified as a major cause of autosomal dominant frontotemporal dementia (FTD) with tau-negative inclusions. The majority of GRN mutations result in the production of a null allele and reduced PG

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3

Lucero, Stephanie Suzanne. "Increasing reading comprehension through mediated joint activity." CSUSB ScholarWorks, 1999. https://scholarworks.lib.csusb.edu/etd-project/1941.

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4

Garratt, Jennifer Clare. "Receptor mediated control of 5-HT neuronal activity." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277492.

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5

de, Beer Irving. "Screening of plant-mediated nanoparticles for antifungal activity." University of the Western Cape, 2020. http://hdl.handle.net/11394/7955.

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>Magister Scientiae - MSc<br>Nanotechnology is spreading rapidly across the world as an extremely powerful technology. Nanoscience and nanotechnology are innovative scientific advancements that have been introduced only in this century. Nanotechnology has developed as the scientific advancement to grow and transform the entire agri-food area, with the potential to elevate global food production, in addition to the nutritional value, quality, and safety of food and food products. It has gained recognition due to its variability in shape, size, and dimension and how it correlates to its possibil

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6

Bermudez, Yira. "Growth Factor-Mediated Telomerase Activity in Ovarian Cancer Cells." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002028.

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7

Su, Jennifer Jeeye. "Screening for molecules essential in activity-mediated neurotransmitter specification." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1467929.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed September 15, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 25-28).

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8

Chesarino, Nicholas M. "Defining the Biochemical Factors Regulating IFITM3-Mediated Antiviral Activity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480426112676394.

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9

Thomas, Dafydd Huw. "Regulation of Syk activity in GPVI-mediated platelet activation." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/92028.

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Pharmacology<br>Ph.D.<br>Activation of platelets is essential for hemostasis. Following damage to the vascular endothelium collagen is exposed, to which platelets stably adhere. After adhesion on collagen, a signaling cascade is initiated, mediated by Glycoprotein VI (GPVI), which results in platelet activation. A major signaling protein in GPVI signaling is Spleen tyrosine kinase (Syk). It undergoes phosphorylation and activation following GPVI stimulation. Syk's central role in this physiological process suggests regulation of its activity is required to maintain the platelets response to co

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10

Menendez, Rita Maria. "Cultural-Historical Activity Perspectives on the Effects of Participation in Teacher-Mediated, Computer-Mediated Reading Instruction." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/353.

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The purpose of this study was to determine the effects of participation in Read 180, a teacher-mediated, computer-mediated reading instruction program, on the reading proficiency of 4th and 5th grade English Language Learners. The students who participated in the Read 180 program scored below the 25th percentile on the Florida Comprehensive Assessment Test (FCAT). Cultural-historical activity theory guided the research. Research questions for the study were answered with quantitative and qualitative methods. The questions asked were: 1. What are the effects of participation in Read 180, a teac

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11

Dhamankar, Varsha Sudhir. "Cytochrome P450-mediated drug metabolizing activity in the nasal mucosa." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1585.

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Pre-systemic elimination by local enzymatic degradation can play a key role in limiting the bioavailability of intranasally administered drugs. Despite remarkable advancement in the characterization of the nasal biotransformative enzymes, knowledge of the role of the nasal mucosa in limiting bioavailability of therapeutic agents is still inadequate. The aim of this work was to evaluate the expression and substrate biotransformation activity of cytochrome P450 enzymes in the nasal mucosa using bovine olfactory and respiratory explants as in vitro models. Gene expression and localization of majo

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12

Marsh, Tim. "Towards invisible style of computer-mediated activity : transparency and continuity." Thesis, University of York, 2002. http://etheses.whiterose.ac.uk/14065/.

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13

Smith, Lorna Ionie Freda. "Transducer of regulated CREB activity in ACTH-mediated Star transcription." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702435.

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The biosynthesis of glucocorticoids in the adrenal, the end product of the HPA axis, is regulated by the availability and activation of the labile protein StAR, which is subject to tight transcriptional regulation by ACTH. · Of the many factors involved in Star transcription, CREB and its co-activator Transducer of regulated CREB activity (TORC 1-3), have previously been established to be involved in mediating ACTH-induced transcriptional increases in adrenal zona fasciculata cells, through activation of the cAMP pathway. However, the vast majority of previous studies have been performed in vi

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14

Codina, Sala Joan. "Activity Mediated Interactions in Soft Matter. Structure, Interactions, and Phase Transitions." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663988.

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In this thesis we asses the phenomena of arising interactions in soft matter in coexistence with soft active matter. As a non-equilibrium bath we introduce ensembles of self-propelled particles, granular shaken beds, and photo active catalytic particles. We start the thesis with a detailed study of the widely used Active Brownian Particle (ABP) model. This model exhibits a non-equilibrium phase transition which has been intensively studied in recent years, we have finally reported that this transition satisfies all features of equilibrium first order phase transitions. Then, we introduce align

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15

Devlin, Marni Allison. "The characterization of TSH-mediated phospholipase D activity in thyroid cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/MQ47020.pdf.

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16

Burns, Danny Michael. "Pineal-mediated inhibition of prolactin cell activity: Investigation of dopaminergic involvement." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184696.

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The purpose of these studies was to determine whether the inhibitory effects of short photoperiod exposure on prolactin cell activity in male Syrian hamsters and/or the inhibitory effects of melatonin treatment on the growth and activity of diethylstilbestrol- (DES) induced prolactinomas in Fisher 344 (F344) rats were possibly mediated through alterations in dopaminergic regulatory mechanisms. In both the hamster and the rat, changes in hypothalamic dopamine neuronal activity and changes in pituitary responsiveness to dopamine have been suggested as possible mechanisms in the prolactin-inhibit

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17

Kawaguchi, Kousuke. "Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity." Kyoto University, 2018. http://hdl.handle.net/2433/231002.

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18

Khaliullina-Skultety, Helena. "Patched-mediated regulation of Smoothened trafficking and activity by Lipophorin-derived lipids." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-65291.

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Hedgehog is a lipid-linked morphogen that is carried on lipoprotein particles and that regulates both patterning and proliferation in a wide variety of vertebrate and invertebrate tissues. Hyperactivity of Hedgehog signaling causes numerous forms of cancer. Hedgehog acts by binding to its receptor Patched, relieving the suppression of Smoothened and initiating Smoothened signaling. The mechanism by which Patched represses Smoothened has been unclear, but correlates with reduced Smoothened levels on the basolateral membrane. The structural homology of Patched with the Niemann-Pick-Type C1 prote

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19

Jaldemark, Jimmy. "Participation in a boundless activity : Computer-mediated communication in Swedish higher education." Doctoral thesis, Umeå universitet, Pedagogik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30351.

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The general purpose of this thesis is to understand how participation in the activity of education relates to communication and tools. This purpose unfolds by drawing on possible conceivable consequences. In the fulfilment of this purpose communication, education, participation, and tools are analytically linked by a common denominator: human action. The commentary text expounds on these links, while the four included papers illustrate how these links operate in educational settings. The general purpose serves to frame a narrower purpose: a discussion of participation through computer-mediated

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20

Birch, Paul James. "Testing Mediated Effects of a Sex Education Program on Youth Sexual Activity." DigitalCommons@USU, 2011. https://digitalcommons.usu.edu/etd/1023.

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Empirical investigations have identified hundreds of factors that predict whether youth engage in sexual activity (YSA). To promote optimal health and the avoidance of unhealthy or problematic outcomes that can result from YSA, sex education programs have been extensively developed and evaluated. Many evaluations have identified the effect of the program on immediate outcomes such as attitudes and intentions, others have examined subsequent behavioral and health outcomes, and some have done both. The purpose of this study was to extend the evaluation literature by testing a mediated effects mo

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21

Nithianandarajah-Jones, Gopika. "The role and regulation of VEGF-mediated ERK5 activity in endothelial cells." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2008164/.

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Extracellular signal-regulated kinase 5 (ERK5) is the newest member of the mitogen- activated protein kinase (MAPK) family following the discovery of ERK1/2, JNK and p38 MAPK. ERK5 consists of an N-terminal kinase domain, similar to the other MAPK members, and a large C-terminal domain, which is unique in structure and function from the other MAPK members. ERK5 is activated in response to a multitude of extracellular stimuli, including pro-angiogenic factors in endothelial cells. The physiological importance of ERK5 was highlighted following Erk5 gene ablation in mice, where a severe disruptio

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22

Oprica, Mircea. "Cytokines in the nervous system with emphasis on interleukin-1 receptor-mediated activity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-288-8/.

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23

GaÌnem, GutieÌrrez Gabriela Adela. "The processes of collaborative activity in computer-mediated tasks : in search of microgenesis." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414610.

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24

Kim, Tae Whan. "The role of kinase activity of IRAK₄ in Tlr/il-1r mediated signaling." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1228500771.

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25

Fok, Megan. "Early Parasympathetic Activity Predicts Later Childhood Social Functioning as Mediated by Emotion Regulation." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103751.

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Theories of emotion regulation and social engagement indicate that resting and reactive respiratory sinus arrhythmia (RSA), which reflect vagal activity, in early childhood can inform the development of social and emotional behaviors later in life. Low RSA at baseline and during a stressful task have been associated with symptoms of ED and disorders characterized by social impairments. The current study examined the mediating role of ED at 24-months-old (mo) on the prospective association between early infant resting and reactive RSA at 5 mo on social functioning outcomes at 48 mo, and the med

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26

Kim, Tae Whan. "THE ROLE OF KINASE ACTIVITY OF IRAK4 IN TLR/IL-1R-MEDIATED SIGNALING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228500771.

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27

Matsumura, Kazuyoshi. "Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3." Kyoto University, 2003. http://hdl.handle.net/2433/148461.

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28

Brewer, Cynthia. "Use of PC12 cells to characterize PAFR-GPCR-mediated activity in neural precursors." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9170.

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Platelet activating factor (PAF: 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid mediator produced by neurons and glial cells. In adult central nervous system (CNS), physiological concentrations of PAF have been shown to mediate long-term potentiation, the purported cellular basis of mammalian learning and memory. Elevated levels of PAF are implicated in the pathophysiology of a number of neurodegenerative diseases, ischemia-reperfusion injury, human immunodeficiency virus-1 (HIV-1) associated dementia, and the developmental brain disorder Miller-Dieker Sy

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29

Patel, Shwetak Naran. "Infrastructure mediated sensing." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24829.

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Thesis (Ph.D.)--Computing, Georgia Institute of Technology, 2009.<br>Committee Chair: Abowd, Gregory; Committee Member: Edwards, Keith; Committee Member: Grinter, Rebecca; Committee Member: LaMarca, Anthony; Committee Member: Starner, Thad.

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30

Kisten, Najwa. "The immune-modulating activity of Sutherlandia frutescens." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6371_1299578884.

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<p>The aim of this study was to investigate the effects of Sutherlandia frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations of Sutherlandia frutescens were stimulated in vitro with either Lipopolysaccharide (LPS) or Phytohaemagglutinin (PHA). Results show that Sutherlandia frutescens is not toxic at any of the concentrations tested. The addition of Sutherlandia frutescens at high concentrations to the stimulated whole blood cell cultures reflects a significant down regulation of Interleuk

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31

Singh, Jaspal 1978. "Corepressor-specific control of ROR [alpha] transcriptional activity mediated by a calcium-dependent pathway." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81440.

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Eukaryotic gene regulation by members of the nuclear receptor superfamily is crucial for a vast array of cellular and physiological processes including development, differentiation, proliferation and homeostasis. Regulation of the transcriptional activity of nuclear receptors occurs through the exchange of corepressor and coactivator complexes in a ligand-dependent manner. However, this may not be the case for orphan nuclear receptors, including RORalpha. Instead, RORalpha orphan nuclear receptor activity is modulated by Ca 2+/calmodulin-dependent protein kinase IV (CAMKIV), through a y

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32

Buccellato, Matthew Allan. "Host-mediated Alteration of Measles Virus Polymerase Activity: Consequences for the Outcome of Infection." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1210961676.

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33

Koliopoulos, Marios Grigorios. "Structural and functional basis for TRIM25 E3 ligase catalytic activity and NS1-mediated suppression." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10038260/.

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Ubiquitination is a post-translational modification of proteins with broad regulatory roles across cellular biology. This process involves the addition of ubiquitin molecules on target proteins, altering their cellular role and properties. Ubiquitination is performed by an enzymatic cascade consisting of three enzymes: ubiquitin activating enzymes (E1), ubiquitin conjugating enzymes (E2) and ubiquitin ligases (E3). The tripartite motif (TRIM) family of proteins constitutes one of the largest subfamilies of RING E3 ligases and the majority of them are contributing to the regulation of innate im

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34

Lycksam, Jonas. "Metal Mobilization in Mine Waste as a Result of Oxidation and Bacterial Mediated Activity." Thesis, Umeå universitet, Kemiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-95210.

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35

Mensching, Daniel [Verfasser], and Dietmar [Akademischer Betreuer] Kuhl. "Investigation of activity dependent Arl5b mediated signaling in synaptic plasticity / Daniel Mensching. Betreuer: Dietmar Kuhl." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1103233211/34.

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36

Amin, Ahmed [Verfasser]. "NRF2 mediated oxidative stress response activity during early in vitro bovine embryo development / Ahmed Amin." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/107726920X/34.

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37

Yang, Bo. "Activity-mediated plasticity of GABA equilibrium potential in the CA1 region of the rat hippocampus." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/38164.

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γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). GABAA receptor mediated inhibitory postsynaptic currents (IPSCs) can affect both excitatory and inhibitory synapses, and thus, regulate CNS network activity. Amplitudes and the direction of IPSCs are subject to changes in the GABA equilibrium potential (EGABA). Changes in EGABA can affect various types of activity-dependent plasticity of the IPSC. Interestingly, EGABA is set at a more positive level in neonatal than that in adult central neurons, rendering GABA excitatory in neonate

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38

Deault-Bonin, Marie. "Microcell-mediated chromosome transfer shows that inhibition of telomerase activity occurs at the transcriptional level." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84503.

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We hypothesized that if normal cells carry a regulator which is inactivated in cancer cells, the transfer of this regulator from a normal cell to a cancerous one should inactivate the telomerase. Available in the laboratory was a panel of mouse/human microcell hybrids, each containing a tagged normal human chromosome fragment integrated into a mouse melanoma (telomerase-positive) background. We screened these hybrids for telomerase activity using both the polymerase chain reaction (PCR)-based telomeric repeat amplification protocol (TRAP) assay and mTERT mRNA amplification.<br>We were a

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39

Mensching, Daniel Verfasser], and Dietmar [Akademischer Betreuer] [Kuhl. "Investigation of activity dependent Arl5b mediated signaling in synaptic plasticity / Daniel Mensching. Betreuer: Dietmar Kuhl." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1103233211/34.

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40

Kirkman, Philip. "Secondary music students' compositional development with computer-mediated environments in classroom communities." Thesis, University of Cambridge, 2012. https://www.repository.cam.ac.uk/handle/1810/244366.

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Over the last decade digital technologies have brought significant changes to classroom music, promising support for the realisation of a musical education for all students. National curricula and exam specifications continue to embed technology more deeply. While these changes increasingly impact on music classrooms, there is a growing awareness that the presence of digital technologies may not always promote meaningful compositional development, particularly at GCSE level. A ‘musical’ curriculum seeks to promote meaningful compositional development by building upon a student’s previous music

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41

Rabadán, Lozano M. Ángeles. "Genetic analysis of neural crest migration: Requirement of Dapper2-mediated inhibition of the Wnt canonical activity." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83279.

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Numerous initiatives to improve our understanding of cancer biology have been lunched in different laboratories that aim to describe the interactome and gene-expression profile in different tumour cell line. It is now clear that the different strategies of cell migration observed in cancer are reminiscent of the different migratory strategies observed during embryo development. These similarities suggest that developmental program that has to be kept off after embryogenesis may be induced by spontaneous genetics modifications that produce tumour cells. In this study we went inside the gene

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42

Mortimer, Heather Jane. "Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1409/.

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Abstract Background: Pulmonary hypertension (PH) is a rare condition that can occur as a primary disease process, Idiopathic Pulmonary Hypertension (IPH) or secondary to other disorders. In Familial IPH mutations have been identified in the bone morphogenetic protein receptor II gene (BMPRII) (chromosome 2q32-31) a member of the Transforming Growth Factor  (TGF) (Lane et al, 2000). Despite the mutation being present in all cells, vascular wall remodelling is only seen in the pulmonary circulation with marked thickening of the intima and neointimal formation, muscularisation of small-generati

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43

Kriel, Yusra. "The immune-modulating activity of Artemisia afra." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_4025_1299669473.

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<p>This study shows that herbs can be effectively screened for potiential bio-activity using in vitro methods. Further studies will be needed to better explore Artemisia afra&rsquo<br>s effect on immunoregulation, particularly long term effects of the herb on the immune system and its effect on other disease states.</p>

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Ramirez, Artemio. "The impact of inter-activity on relationship development: Testing predicted outcome value theory on computer-mediated interactions." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289223.

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This study proposed and tested a model of relational development in mediated environments. Burgoon and colleagues' principle of inter-activity (Burgoon, Bonito, Bengtsson, Ramirez, Dunbar, & Miczo, 1999), Sunnafrank's (1986) Predicted Outcome Value theory, and Walther's (1996; Walther & Burgoon, 1992) Social Information Processing theory were reviewed and each incorporated into a model for understanding how decisions to pursue relationships in mediated environments occur. The present study examined the role of media and information richness and mediation within the model's framework. Dyads con

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Patwardhan, Anjali A. "Mechanistic studies of copper(II) aminoglycoside mediated DNA damage and magnesium catalyzed nuclease activity of hammerhead ribozyme." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1060971975.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 91 p.; also includes graphics (some col.) Includes bibliographical references (p. 82-91). Available online via OhioLINK's ETD Center

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Kommajosyula, srinivasa prasad. "NEUROACTIVE AGENTS-MEDIATED CHANGES IN NEURONAL NETWORK ACTIVITY CONTROLS SUSCEPTIBILITY TO SUDDEN UNEXPECTED DEATH IN EPILEPSY (SUDEP)." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1368.

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The incidence of sudden death is higher in epileptic people compared to the general population and sudden unexpected death in epilepsy (SUDEP) is second only to stroke in the years of potential life loss among the major neurological disorders. In the majority of observed human SUDEP cases, respiratory dysfunction post-seizure is shown to be the primary initiating event leading to cardiac asystole and death. During seizures, several neuroactive agents are shown to be released, including serotonin and adenosine. Previous research has shown the effects of these neuroactive agents on seizure and r

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47

Jin, Li. "Computer-mediated peer response in a level-IV ESL academic writing class : a cultural historical activity theoretical perspective." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002033.

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Doidge, Rachel L. "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13012/.

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The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases. It was unclear whether the anti-proliferative activity of the BTG/TOB proteins was mediated through interactions with Caf1a (CNOT7) and Caf1b (CNOT8). To address this we further characterised the amino acid residues located along the BTG2 and TOB1 interaction surface wit

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Bray, Natasha. "IL-1β-mediated changes in cerebral perfusion and neural activity in a rat model of neuroinflammation and excitotoxicity". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/il1mediated-changes-in-cerebral-perfusion-and-neural-activity-in-a-rat-model-of-neuroinflammation-and-excitotoxicity(f9784ec8-0438-4d3c-aef1-b56a9b86ac01).html.

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Neuroinflammation is a major driver of secondary brain cell death after ischaemic stroke, seizure activity and traumatic brain injury. In a model of excitotoxic neuroinflammation, striatal injection of a toxic dose of AMPA causes cell death in the striatum after 24 hours. Co-injection of AMPA with the pro-inflammatory cytokine interleukin-1β (IL-1β) leads to additional cortical cell death. Injected alone, IL-1β leads to little or no cell death. It is hypothesised that IL-1β may exacerbate cell death by interfering with blood flow coupling. In the first study, two-dimensional optical imaging sp

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Olivier, Joy. "Mediated activity and the role of technology in peer-to-peer learning at the University of Fort Hare." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/14351.

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Abstract:

Includes bibliographical references.<br>The following calls for research into the ways in which South African university students use technology for peer-to-peer learning (Czerniewicz and Brown, 2005). This study aims to explore the ways in which students mediate one another's learning and the ways in which they use (and don't use) information and communications technology (ICT) to do so. This study provides a snapshot of eleven University of Fort Hare students' peer-to-peer learning strategies. In exploring this phenomenon in context, the social and cultural factors are analysed using Activit

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