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1

Min, Xiao, Xiaohan Zhang, Ningning Sun, Srijan Acharya та Kyeong-Man Kim. "Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity". Biochemical Pharmacology 170 (грудень 2019): 113675. http://dx.doi.org/10.1016/j.bcp.2019.113675.

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2

Ha, Seungshin, and Lori Redmond. "ERK mediates activity dependent neuronal complexity via sustained activity and CREB-mediated signaling." Developmental Neurobiology 68, no. 14 (2008): 1565–79. http://dx.doi.org/10.1002/dneu.20682.

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3

Bodker, Susanne. "Computers in Mediated Human Activity." Mind, Culture, and Activity 4, no. 3 (1997): 149–58. http://dx.doi.org/10.1207/s15327884mca0403_2.

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4

Lou, Yanyan, Chengwen Liu, Gregory Lizée, et al. "Antitumor Activity Mediated by CpG." Journal of Immunotherapy 34, no. 3 (2011): 279–88. http://dx.doi.org/10.1097/cji.0b013e31820d2a05.

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5

Crunkhorn, Sarah. "Understanding NMDA-mediated ketamine activity." Nature Reviews Drug Discovery 20, no. 9 (2021): 668. http://dx.doi.org/10.1038/d41573-021-00135-2.

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Jung, Hyun Jun, Sang-Yeob Kim, Hyo-Jung Choi та ін. "Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells". American Journal of Physiology-Renal Physiology 308, № 5 (2015): F473—F486. http://dx.doi.org/10.1152/ajprenal.00052.2014.

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Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct. AVP regulates AQP2 expression primarily via Gsα/cAMP/PKA signaling. Tankyrase, a member of the poly(ADP-ribose) polymerase family, is known to mediate Wnt/β-catenin signaling-induced gene expression. We examined whether tankyrase plays a role in AVP-induced AQP2 regulation via ADP-ribosylation of G protein-α (Gα) and/or β-catenin-mediated transcription of AQP2. RT-PCR and immunoblotting analysis revealed the mRNA and protein expression of tankyrase in mouse kidney and mouse collecti
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Fujii, Shinichiro, Shinichiro Motohashi, Kanako Shimizu, Toshinori Nakayama, Yohei Yoshiga, and Masaru Taniguchi. "Adjuvant activity mediated by iNKT cells." Seminars in Immunology 22, no. 2 (2010): 97–102. http://dx.doi.org/10.1016/j.smim.2009.10.002.

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8

Woodle, M. C., P. Scaria, S. Ganesh, et al. "Sterically stabilized polyplex: ligand-mediated activity." Journal of Controlled Release 74, no. 1-3 (2001): 309–11. http://dx.doi.org/10.1016/s0168-3659(01)00339-x.

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9

te Velde, A. A., and C. G. Figdor. "Monocyte mediated cytotoxic activity against melanoma." Melanoma Research 1, no. 5 (1992): 303–10. http://dx.doi.org/10.1097/00008390-199201000-00001.

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10

Aston, Roger, William B. Cowden, and Gordon L. Ada. "Antibody-mediated enhancement of hormone activity." Molecular Immunology 26, no. 5 (1989): 435–46. http://dx.doi.org/10.1016/0161-5890(89)90103-x.

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11

Liu, Yanfang, Yanhui Lv, Yanyan Zhu, Di Liu, Ruilong Zong, and Yongfa Zhu. "Fluorine mediated photocatalytic activity of BiPO4." Applied Catalysis B: Environmental 147 (April 2014): 851–57. http://dx.doi.org/10.1016/j.apcatb.2013.09.050.

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12

Cao, Yuanyuan, and Yapei Wang. "Temperature-Mediated Regulation of Enzymatic Activity." ChemCatChem 8, no. 17 (2016): 2740–47. http://dx.doi.org/10.1002/cctc.201600406.

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13

Li, Guangbi, Dandan Huang, Jinni Hong, Owais M. Bhat, Xinxu Yuan, and Pin-Lan Li. "Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes." American Journal of Physiology-Cell Physiology 317, no. 3 (2019): C481—C491. http://dx.doi.org/10.1152/ajpcell.00150.2019.

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The transient receptor potential mucolipin 1 (TRPML1) channel has been reported to mediate lysosomal Ca2+ release that is involved in Ca2+-dependent lysosome trafficking and autophagic flux. However, this regulatory mechanism of lysosomal TRPML1 channel activity in podocytes remains poorly understood. In the present study, we tested whether the TRPML1 channel in podocytes mediates lysosome trafficking, which is essential for multivesicular body (MVB) degradation by lysosomes. We first demonstrated the abundant expression of TRPML1 channel in podocytes. By GCaMP3 Ca2+ imaging, we characterized
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14

Lou, Bin, Qi Liu, Jiahui Hou, et al. "2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity." Journal of Biological Chemistry 293, no. 47 (2018): 18328–36. http://dx.doi.org/10.1074/jbc.ra118.005904.

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2-Hydroxy-oleic acid (2OHOA) is a potent anticancer drug that induces cancer cell cycle arrest and apoptosis. Previous studies have suggested that 2OHOA's anticancer effect is mediated by SMS activation in cancer cells, including A549 and U118 cells. To confirm this phenomenon, in this study, we treated both A549 and U118 cells with 2OHOA and measured SMS activity. To our surprise, we found neither 2OHOA-mediated SMS activation nor sphingomyelin accumulation in the cells. However, we noted that 2OHOA significantly reduces phosphatidylcholine in these cells. We also did not observe 2OHOA-mediat
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15

Friedmann, Igor, Ehud Hauben, Eti Yoles, Lena Kardash, and Michal Schwartz. "T cell-mediated neuroprotection involves antithrombin activity." Journal of Neuroimmunology 121, no. 1-2 (2001): 12–21. http://dx.doi.org/10.1016/s0165-5728(01)00397-6.

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16

Stover, D. R., J. Liebetanz, and N. B. Lydon. "Cdc2-mediated modulation of pp60c-src activity." Journal of Biological Chemistry 269, no. 43 (1994): 26885–89. http://dx.doi.org/10.1016/s0021-9258(18)47102-5.

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17

van Rhee, A. M., A. P. IJzerman, and W. Soudijn. "Purinoceptor mediated inhibition of adenylate cyciase activity." European Journal of Pharmacology 183, no. 6 (1990): 2168. http://dx.doi.org/10.1016/0014-2999(90)93694-l.

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18

Binns, S., B. Purgina, C. Bergeron, et al. "Light-Mediated Antifungal Activity of Echinacea Extracts." Planta Medica 66, no. 03 (2000): 241–44. http://dx.doi.org/10.1055/s-2000-8573.

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19

Mueller, V. J. "Monitoring Clathrin-Mediated Endocytosis during Synaptic Activity." Journal of Neuroscience 24, no. 8 (2004): 2004–12. http://dx.doi.org/10.1523/jneurosci.4080-03.2004.

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20

Wang, Pei, Yujie Bai, Bangrong Song, et al. "PP1A-Mediated Dephosphorylation Positively Regulates YAP2 Activity." PLoS ONE 6, no. 9 (2011): e24288. http://dx.doi.org/10.1371/journal.pone.0024288.

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21

Mathis, C., and C. H. Malbert. "Erythromycin gastrokinetic activity is partially vagally mediated." American Journal of Physiology-Gastrointestinal and Liver Physiology 274, no. 1 (1998): G80—G86. http://dx.doi.org/10.1152/ajpgi.1998.274.1.g80.

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Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. Vagal cooling during erythromycin infusion produced a marked decreased of pyloric outflow (23 ± 1.1 vs. 50 ± 2.6 ml/min) related to a reduced s
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22

Knecht, Leslie D., Nur Ali, Yinan Wei, J. Zach Hilt, and Sylvia Daunert. "Nanoparticle-Mediated Remote Control of Enzymatic Activity." ACS Nano 6, no. 10 (2012): 9079–86. http://dx.doi.org/10.1021/nn303308v.

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23

QIAN, Mingwei, John W. EATON, and Simon P. WOLFF. "Cyanate-mediated inhibition of neutrophil myeloperoxidase activity." Biochemical Journal 326, no. 1 (1997): 159–66. http://dx.doi.org/10.1042/bj3260159.

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Cyanate (CNO-) forms spontaneously in solutions containing urea, and is present in urine and the body fluids of uraemic patients. We have explored the possibility that CNO- might be one of the unknown substances responsible for the reported impairment, by urine and uraemic plasma, of neutrophil oxidative metabolism (especially as measured by luminol-enhanced chemiluminescence). Luminol-enhanced chemiluminescence generated by human neutrophils derives predominantly from the activity of myeloperoxidase (MPO) which produces hypochlorous acid from H2O2 and Cl-. We hypothesized that CNO- (which res
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24

Shadan, F. F., and L. P. Villarreal. "Parvovirus-mediated antineoplastic activity exploits genome instability." Medical Hypotheses 55, no. 1 (2000): 1–4. http://dx.doi.org/10.1054/mehy.1999.0887.

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25

Daie, Jaleh. "Hormone-mediated enzyme activity in source leaves." Plant Growth Regulation 4, no. 3 (1986): 287–91. http://dx.doi.org/10.1007/bf00028172.

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26

Wallach, Gilad, Jules Lallouette, Nitzan Herzog, et al. "Glutamate Mediated Astrocytic Filtering of Neuronal Activity." PLoS Computational Biology 10, no. 12 (2014): e1003964. http://dx.doi.org/10.1371/journal.pcbi.1003964.

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27

Melo, Fábio R., Mariana S. Pereira, Débora Foguel, and Paulo A. S. Mourão. "Antithrombin-mediated Anticoagulant Activity of Sulfated Polysaccharides." Journal of Biological Chemistry 279, no. 20 (2004): 20824–35. http://dx.doi.org/10.1074/jbc.m308688200.

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28

Ashwood-Smith, M., C. Stanley, G. H. N. Towers, and P. J. Warrington. "UV-A-MEDIATED ACTIVITY OF p-METHOXYMETHYLCINNAMATE." Photochemistry and Photobiology 57, no. 5 (1993): 814–18. http://dx.doi.org/10.1111/j.1751-1097.1993.tb09216.x.

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29

Vorhagen, Susanne, Joanna Jackow, Simona Georgina Mohor, et al. "Lineage Tracing Mediated by Cre-Recombinase Activity." Journal of Investigative Dermatology 135, no. 1 (2015): 1–4. http://dx.doi.org/10.1038/jid.2014.472.

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30

Miragliotta, G., M. Lafata, and E. Jirillo. "Anti-bacterial activity mediated by human platelets." Agents and Actions 25, no. 3-4 (1988): 401–6. http://dx.doi.org/10.1007/bf01965049.

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31

Monro, Susan M. A., Krista M. Cottreau, Colin Spencer, et al. "Copper-mediated nuclease activity of jadomycin B." Bioorganic & Medicinal Chemistry 19, no. 11 (2011): 3357–60. http://dx.doi.org/10.1016/j.bmc.2011.04.043.

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32

Shiferaw, Yohannes, Wei Chen, and Mesfin Asfaw. "Calcium Mediated Triggered Activity in Cardiac Tissue." Biophysical Journal 102, no. 3 (2012): 672a. http://dx.doi.org/10.1016/j.bpj.2011.11.3659.

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33

P. Eswara Prasad, A. Jayasri, K. Padmaja B. D. P. Kala Kumar, and M. Gnanaprakash K. Kavitha. "Antibacterial Activity of Thespesia populnea Mediated Nanoparticles." International Journal of Current Microbiology and Applied Sciences 10, no. 2 (2021): 913–18. http://dx.doi.org/10.20546/ijcmas.2021.1002.107.

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34

Hwang, Hyun Sub, Sang Gil Hwang, Jun-Ho Cho, et al. "CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1." Journal of Cell Biology 195, no. 3 (2011): 377–86. http://dx.doi.org/10.1083/jcb.201106138.

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Son of sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the guanosine triphosphatases Rac1 and Ras, which mediate signaling initiated by peptide growth factors. In this paper, we show that CIIA is a new binding partner of SOS1. CIIA promoted the SOS1–Rac1 interaction and inhibited the SOS1–Ras interaction. Furthermore, CIIA promoted the formation of an SOS1–EPS8 complex and SOS1-mediated Rac1 activation, whereas it inhibited SOS1-mediated activation of Ras. Transforming growth factor β (TGF-β) up-regulated the expression of CIIA and thereby promoted the asso
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35

Graziani, Annarita, Bernadett Bacsa, Denis Krivic, et al. "Light-Mediated Control over TRPC3-Mediated NFAT Signaling." Cells 9, no. 3 (2020): 556. http://dx.doi.org/10.3390/cells9030556.

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Canonical transient receptor potential (TRPC) channels were identified as key players in maladaptive remodeling, with nuclear factor of activated T-cells (NFAT) transcription factors serving as downstream targets of TRPC-triggered Ca2+ entry in these pathological processes. Strikingly, the reconstitution of TRPC-NFAT signaling by heterologous expression yielded controversial results. Specifically, nuclear translocation of NFAT1 was found barely responsive to recombinant TRPC3, presumably based on the requirement of certain spatiotemporal signaling features. Here, we report efficient control of
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36

Park, S., T. L. Scheffler, S. S. Rossie, and D. E. Gerrard. "AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity." Cell Calcium 53, no. 3 (2013): 217–23. http://dx.doi.org/10.1016/j.ceca.2012.12.001.

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37

Poore, C. P., J. R. Sundaram, T. K. Pareek, et al. "Cdk5-Mediated Phosphorylation of -Catenin Regulates Its Localization and GluR2-Mediated Synaptic Activity." Journal of Neuroscience 30, no. 25 (2010): 8457–67. http://dx.doi.org/10.1523/jneurosci.6062-09.2010.

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38

Kitaura, Hideki, Masahiko Ishida, Keisuke Kimura, et al. "Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity." Analytical Cellular Pathology 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8047610.

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Lipopolysaccharide (LPS) is an endotoxin and bacterial cell wall component that is capable of inducing inflammation and immunological activity. Muramyl dipeptide (MDP), the minimal essential structural unit responsible for the immunological activity of peptidoglycans, is another inflammation-inducing molecule that is ubiquitously expressed by bacteria. Several studies have shown that inflammation-related biological activities were synergistically induced by interactions between LPS and MDP. MDP synergistically enhances production of proinflammatory cytokines that are induced by LPS exposure. I
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39

ERTOSUN, Mustafa Gökhan, SAYRA DİLMAÇ, FATMA ZEHRA HAPİL ZEVKLİLER, GAMZE TANRIÖVER, SADİ KÖKSOY, and OSMAN NİDAİ ÖZEŞ. "Regulation of E2F1 activity via PKA-mediated phosphorylations." TURKISH JOURNAL OF BIOLOGY 44, no. 5 (2020): 215–29. http://dx.doi.org/10.3906/biy-2003-9.

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40

Keerthiga, Nagarajan, Roy Anitha, Rajeshkumar S Rajeshkumar, and Thangavelu Lakshmi. "Antioxidant Activity of Cumin Oil Mediated Silver Nanoparticles." Pharmacognosy Journal 11, no. 4 (2019): 787–89. http://dx.doi.org/10.5530/pj.2019.11.125.

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41

Twinkle Francis, Preejitha V B, and Rajeshkumar S. "Antioxidant activity of Cynodon dactylon mediated selenium nanoparticles." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6221–26. http://dx.doi.org/10.26452/ijrps.v11i4.3301.

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The nanoparticles are known to reduce toxicity, enhance bioactivity and improve targeting cells. The metal and metal oxide nanoparticles such as gold, silver, zinc oxide, zirconium oxide, copper oxide, copper sulfide, selenium, hydroxyl apatite, and titanium oxide were used in several biomedical applications especially diagnosis of cancer, etc. The selenium nanoparticles (SeNPs) are explored due toits unique characteristics and various known therapeutic benefits such as anti bacterial, anti fungal and anti cancer activities. The selenium nanoparticles actively involved in the free radical scav
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42

Coddington, Luke T., Stephanie Rudolph, Patrick Vande Lune, Linda Overstreet-Wadiche, and Jacques I. Wadiche. "Spillover-Mediated Feedforward Inhibition Functionally Segregates Interneuron Activity." Neuron 78, no. 6 (2013): 1050–62. http://dx.doi.org/10.1016/j.neuron.2013.04.019.

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43

Zhang, Tao, Yen-Ching Wu, Patrick Mullane, et al. "FUS Regulates Activity of MicroRNA-Mediated Gene Silencing." Molecular Cell 69, no. 5 (2018): 787–801. http://dx.doi.org/10.1016/j.molcel.2018.02.001.

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44

Poehner, Matthew E., and Paolo Infante. "Mediated Development: Inter-psychological activity for L2 education." Language and Sociocultural Theory 2, no. 2 (2015): 161–83. http://dx.doi.org/10.1558/lst.v2i2.26982.

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45

Joshi, Gaurav, Jatinder Kaur, Praveen Sharma, et al. "p53-Mediated Anticancer Activity of Citrullus colocynthis Extracts." Natural Products Journal 9, no. 4 (2019): 303–11. http://dx.doi.org/10.2174/2210315509666181203114329.

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Background: Current anticancer therapeutics comes with significant side effects and thus focus is shifting towards minimizing the side effects or to avoid the disease altogether. Thus, various natural products are being investigated for their potential therapeutic values which can be easily included in daily diet of a person. Citrullus colocynthis (L.) fruit is commonly used in traditional medicines and is known to have antioxidant effects, thus may possess potent anticancer activity as well. Objectives: To establish the anticancer potential of fruit belonging to Citrullus colocynthis (L.) and
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46

Murayama, Masanori, Lucy M. Palmer, Sean C. Murphy, and Matthew E. Larkum. "GABAB-mediated inhibition of dendritic activity in vivo." Neuroscience Research 71 (September 2011): e15. http://dx.doi.org/10.1016/j.neures.2011.07.058.

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47

Köllnberger, Andreas, Rainer Schrader, and Christoph A. Briehn. "Carboxylic acid mediated antimicrobial activity of silicone elastomers." Materials Science and Engineering: C 113 (August 2020): 111001. http://dx.doi.org/10.1016/j.msec.2020.111001.

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48

Dobrev, Dobromir, and Xander H. T. Wehrens. "Calcium-mediated cellular triggered activity in atrial fibrillation." Journal of Physiology 595, no. 12 (2017): 4001–8. http://dx.doi.org/10.1113/jp273048.

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49

Ding, Yu-Shin, Jean Logan, Rob Bermel, et al. "Dopamine Receptor-Mediated Regulation of Striatal Cholinergic Activity." Journal of Neurochemistry 74, no. 4 (2002): 1514–21. http://dx.doi.org/10.1046/j.1471-4159.2000.0741514.x.

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50

Thorne, Steven L. "‘Community’, semiotic flows, and mediated contribution to activity." Language Teaching 42, no. 1 (2009): 81–94. http://dx.doi.org/10.1017/s0261444808005429.

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This article begins with an overview and problematization of the term community through a brief assessment of its history, diverse uses, core attributes, heterogeneous elements, and collocational companions. Following this, I describe demographics and processes associated with collective engagement in digitally mediated environments. Utilizing select alternatives to the term ‘community’ and incorporating the cultural-historical notions of mediation and activity, I then present research describing exogenous influences affecting educational uses of technology in L2 settings, the use of instant m
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