Academic literature on the topic 'Mediated modelling'

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Journal articles on the topic "Mediated modelling"

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Šulc, Petr, Thomas E. Ouldridge, Flavio Romano, Jonathan P. K. Doye, and Ard A. Louis. "Modelling Toehold-Mediated RNA Strand Displacement." Biophysical Journal 108, no. 5 (2015): 1238–47. http://dx.doi.org/10.1016/j.bpj.2015.01.023.

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Metaxas, Georgios, Panos Markopoulos, and Emile H. L. Aarts. "Modelling social translucency in mediated environments." Universal Access in the Information Society 11, no. 3 (2011): 311–21. http://dx.doi.org/10.1007/s10209-011-0241-0.

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Richards, Shane A., Hugh P. Possingham, and John Noye. "Diel vertical migration: modelling light-mediated mechanisms." Journal of Plankton Research 18, no. 12 (1996): 2199–222. http://dx.doi.org/10.1093/plankt/18.12.2199.

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Forgie, Vicky, and Emma Richardson. "The community outcomes process and mediated modelling." International Journal of Sustainable Development 10, no. 4 (2007): 365. http://dx.doi.org/10.1504/ijsd.2007.017910.

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Kobe, Bostjan, and Mikael Boden. "Computational Modelling of Linear Motif-Mediated Protein Interactions." Current Topics in Medicinal Chemistry 12, no. 14 (2012): 1553–61. http://dx.doi.org/10.2174/156802612802652439.

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Pandey, Sushil Kumar, and Tridib Kumar Goswami. "Modelling perforated mediated modified atmospheric packaging of capsicum." International Journal of Food Science & Technology 47, no. 3 (2012): 556–63. http://dx.doi.org/10.1111/j.1365-2621.2011.02877.x.

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Robertson, Christopher, and Graham A. Worth. "Modelling the vibrationally mediated photo-dissociation of acetylene." Physical Chemistry Chemical Physics 19, no. 43 (2017): 29483–97. http://dx.doi.org/10.1039/c7cp05684b.

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Liu, Ying Hu, De Li Liu, Min An, et al. "Modelling tritrophic interactions mediated by induced defence volatiles." Ecological Modelling 220, no. 23 (2009): 3241–47. http://dx.doi.org/10.1016/j.ecolmodel.2009.07.003.

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Kushagra, Arindam, and V. Ramgopal Rao. "Anomalous diffusion mediated kinetic modelling of surface-stress sensors." Sensors and Actuators B: Chemical 222 (January 2016): 525–30. http://dx.doi.org/10.1016/j.snb.2015.08.107.

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Baker, M., S. Denman-Johnson, B. S. Brook, I. Gaywood, and M. R. Owen. "Mathematical modelling of cytokine-mediated inflammation in rheumatoid arthritis." Mathematical Medicine and Biology 30, no. 4 (2012): 311–37. http://dx.doi.org/10.1093/imammb/dqs026.

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Dissertations / Theses on the topic "Mediated modelling"

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Muresan, Gheorghe. "Using document clustering and language modelling in mediated information retrieval." Thesis, Robert Gordon University, 2002. http://hdl.handle.net/10059/623.

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Our work addresses a well documented problem: users are frequently unable to articulate a query that clearly and comprehensively expresses their information need. This can be attributed to the information need being too ambiguous and not clearly defined in the user's mind, to a lack of knowledge of the domain of interest on the part of the user, to a lack of understanding of a retrieval system's conceptual model, or to an inability to use a certain query syntax. This thesis proposes a software tool that emulates the human search mediator. It helps a user explore a domain of interest, learn its structure, terminology and key concepts, and clarify and refine an information need. It can also help a user generate high-quality queries for searching the World Wide Web or other such large and heterogeneous document collections. Our work was inspired by library studies which have highlighted the role of the librarian in helping the user explore her information need, define the problem to be solved, articulate a formulation of the information need and adapt it for the retrieval system at hand in order to get information. Our approach, mediated access through a clustered collection, is based on an information access environment in which the user can explore a relatively small, well structured, pre-clustered document collection covering a particular subject domain, in order to understand the concepts encompassed and to clarify and refine her information need. At the same time, the user can ostensively indicate clusters and documents of interest so that the system builds a model of the user's topic of interest. Based on this model, the system assists and guides the user's exploration, or generates `mediated queries' that can be used to search other collections. We present the design and evaluation of WebCluster, a system that reifies the concept of mediated retrieval. Additionally, a variety of mediation experiments are presented,which provide guidelines as to which mediation strategies are more appropriate for different types of tasks. A set of experiments is presented that evaluate document clustering's capacity to group together topical documents and support mediation. In this context we propose and experimentally test a new formulation for the cluster hypothesis. We also look at the ability of language models to convey content, to represent topics and to highlight specific concepts in a given context. They are also successfully applied to generate flexible, task-dependent cluster representatives for supporting exploration through browsing and respectively searching. Our experimental results show that mediation has potential to significantly improve user queries and consequently the retrieval effectiveness.
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Majin, Wodu. "Mathematical modelling of GPCR-mediated calcium signalling." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12451/.

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Ca2+ is an important messenger which mediates several physiological functions, including muscle contraction, fertilisation, heart regulation and gene transcription. One major way its cytosolic level is raised is via a G-protein coupled receptor (GPCR)- mediated release from intracellular stores. GPCR’s are the target of approximately 50% of all drugs in clinical use. Hence, understanding the underlying mechanisms of signalling in this pathway could lead to improved therapy in disease conditions associated with abnornmal Ca2+ signalling, and to the identification of new drug targets. To gain such insight, this thesis builds and analyses a detailed mathematical model of key processes leading to Ca2+ mobilisation. Ca2+ signalling is considered in the particular context of the M3 muscarinic receptor system. Guided by available data, the Ca2+ mobilisation model is assembled, first by analysing a base G-protein activation model, and subsequently extending it with downstream details. Computationally efficient designs of a global parameter sensitivity analysis method are used to identify the key controlling parameters with respect to the main features of the Ca2+ data. The underlying mechanism behind the experimentally observed, rapid, amplified Ca2+ response is shown to be a rapid rate of inositol trisphosphate (IP3) formation from Phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis. Using the same results, potential drug targets (apart fromthe GPCR) are identified, including the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and PIP2. Moreover, possible explanations for therapeutic failures were found when some parameters exerted a biphasic effect on the relative Ca2+ increase. The sensitivity analysis results are used to simplify the process of parameter estimation by a significant reduction of the parameter space of interest. An evolutionary algorithm is used to successfully fit the model to a significant portion of the Ca2+ data. Subsequent sensitivity analyses of the best-fitting parameter sets suggest that mechanistic modelling of kinase-mediated GPCR desensitisation, and SERCA dynamics may be required for a comprehensive representation of the data.
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Long, E. A. G. "Modelling microdomain-mediated protein sorting in immunological signalling." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1355593/.

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Compartmentalisation is a fundamental feature of biological systems. The organism as a whole can be seen as a single compartment of the wider ecosystem. At lower scales, we observe biological processes compartmentalised into organs, cells, cell subtypes and organelles. In the highly complex discipline of immunology, compartmentalisation is key in order to respond e ciently to foreign antigens and to maintain the balance between immunity and tolerance. Recent studies have raised questions about the role of compartmentalisation in lipid membranes, from the relatively well described immunological synapse, to the smaller, more transient lipid raft or microdomain. This thesis asks whether, and how, microdomains could in uence the formation of small receptor complexes. Speci cally, we approach what appears to be a simple surface reaction-di usion problem from multiple viewpoints: explicitly simulating particle di usion using a probabilistic pixel-based model, and deriving a deterministic relation between spatial parameters and the timecourse of chemical concentrations throughout the model space. We also show the equivalence between the predictions of these two models, further supporting the validity of our approach. We also embed the results of our model output in an existing model of the immunological response in order to determine the downstream consequences of enhanced receptor organisation. The study gives a broader understanding of the mechanisms involved in microdomain-mediated protein sorting, highlights the degree of interdependence on multiple spatial and chemical parameters and suggests numerous avenues for future research.
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Kelly, Catherine Elizabeth. "Mathematical modelling of macrophage-mediated therapy in cancer." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268496.

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Pierce, Nicholas. "Modelling vitamin B←1←2 - cobalt mediated cyclisation reactions." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367417.

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Slingerland, Martin Jacob (Marc), and University of Lethbridge Faculty of Arts and Science. "Modelling the auxin-mediated vein formation system in plant leaves." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007, 2007. http://hdl.handle.net/10133/673.

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The plant hormone auxin is involved in a wide range of developmental phenomena in plants. It carries out many of its effects through a signalling network involving the regulation of specific genes, including those involved in its own polar transport between cells. These transporters are able to be redistributed between cell faces, causing the asymmetric auxin transport that is a key requirement for the formation of vein patterns in leaves. In this thesis I describe the development of a biochemical kinetics-based model of auxin signalling and transport in a single cell, which displays biologically plausible responses to auxin application. The single-cell model then serves as the basis for a multicell model of auxin-mediated vein formation at a very early stage of leaf formation in Arabidopsis thaliana.<br>ix, 73 leaves : ill. ; 29 cm.
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Forster, Samantha. "In silico modelling of transporter-mediated xenobiotic flux through cells." Thesis, University of Surrey, 2010. http://epubs.surrey.ac.uk/844458/.

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Drug transporters are increasingly recognised as important drivers in the pharmaco- and toxico-kinetic characteristics of therapeutic agents. Preclinical assays are used to determine the effects of transport on the pharmacokinetics and toxicology of a new compound during drug development. However in vitro cell systems and in vivo animal models often give erroneous results due to the differential expression of important proteins within them. In silico models have been employed to help bridge the gap and make more accurate predictions for drug disposition and metabolism; however such models have not incorporated transport kinetics or induction by nuclear receptors. Many current models also use a reductionist approach, whereby a multiple component pathway is described by a single mathematical term, reducing the ability of the simulation to determine the effects of single parameters. The first aim of this research was therefore to assess the differences in drug transporter expression in a variety of human and rat hepatocellular systems compared to liver. RT-PCR and protein analysis of drug transporter levels in vitro and in vivo showed huge differences, with influx transporters generally being under-expressed and efflux transporters over-expressed in vitro compared to in vivo. These differences were more pronounced at the RNA level than protein level. Transporter expression was also shown to be dynamic, changing over time in culture and in response to nuclear receptor activation. The second aim was to generate an in silico model of cellular response to stimuli, using a whole-cell approach to investigate system dynamics. Kinetics for the lifecycle rhodamiae-123 were determined in vitro and incorporated into an in silico model of human hepatocyte disposition that could accurately simulate outcomes in a variety of cell types and make useful predictions of drug disposition from in vitro results. In conclusion, the in silico model revealed that drug transporter expression and activity may affect drug disposition, with uptake processes presenting as the fragile node in the network. Such a model would be useful in the early stages of drug development to improve extrapolation between biological systems and to identify the likely consequences of different expression levels and species inhibition and induction.
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Howitt, Ryan. "Stochastic modelling of repeat-mediated phase variation in Campylobacter jejuni." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52218/.

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It is of interest to determine how populations of bacteria whose genes exhibit an ON/OFF switching property (phase variation) evolve over time from an initial population. By statistical analysis of two in vitro experimental Campylobacter jejuni datasets containing 28 genes assumed to be phase variable, we find evidence of small networks of genes which exhibit dependent evolutionary behaviour. This violates the assumption that the genes in these datasets do not interact with one another in the way they mutate during the division of cells, motivating the development of a model which attempts to explain evolution of such genes with factors other than mutation alone. We show that discrete probability distributions at observation times can be estimated by utilising two stochastic models. One model provides an explanation with mutation rates in genes, resembling a Markov chain under the assumption of having a near infinite population size. The second provides an explanation with both mutation and natural selection. However, the addition of selection parameters makes this model resemble a non-linear Markov process, which makes further analysis less straight-forward. An algorithm is constructed to test whether the mutation-only model can sufficiently explain evolution of single phase variable genes, using distributions and mutation rates from data as examples. This algorithm shows that applying this model to the same phase variable genes believed to show dependent evolutionary behaviour is inadequate. We use Approximate Bayesian Computation to estimate selection parameters for the mutation with selection model, whereby inference is derived from samples drawn from an approximation of the joint posterior distribution of the model parameters. We illustrate this method on an example of three genes which show evidence of dependent evolutionary behaviour from our two datasets.
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Han, Hyungjin Civil &amp Environmental Engineering Faculty of Engineering UNSW. "Mechanisms and modelling of sonochemically-mediated free radical degradation of contaminants." Awarded by:University of New South Wales. Civil & Environmental Engineering, 2009. http://handle.unsw.edu.au/1959.4/43485.

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Hazardous and recalcitrant pollutants in the environments have led to a great many environmental issues these days. Many researchers have focused on the approaches to treatment of these pollutants which contaminate environments such as soil, surface and groundwater. As an advanced oxidation processes (AOPs), sonolysis which is the oxidation technology involving the use of ultrasonic irradiation, has proven to be successful for the treatment and remediation of contaminated environments. In this thesis, hydrogen peroxide formation and formic acid degradation by ultrasonic irradiation of well-characterised solutions are described under various conditions in order to determinate reaction mechanism by which peroxide degradation and contaminant degradation occur. The effect of gas properties and frequency on hydrogen peroxide and formic acid degradation are examined. Experimental results obtained are analyzed in light of the reactions occurring. Successful mathematical modeling of the result s obtained confirms that, for the most part, hydrogen peroxide and formic degradation occur by free radical generation within bubbles with subsequent transfer of these radicals to the bubble-water interface where the majority of the degradation occurs. The effect of Fe(II) addition which can lead to Fenton reactions in the bulk solution are also investigated. Experimental and model results show that the heterogeneous reactions can enhance the degradation of formic acid in the presence of Fe(II). Oxidation of phenol by ultrasonic irradiation under a variety of initial conditions and solution environments is also described and validated by a simple kinetic model. The model developed will be useful for improving our understanding of free radicals behaviour and the interplay between free radical generation and contaminant degradation.
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Chapman, Timothy Peter. "Morphological and neural modelling of the orthopteran escape response." Thesis, University of Stirling, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391494.

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Books on the topic "Mediated modelling"

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Italy) Media Mutations (Conference) (3rd 2011 Bologna. Media Mutations: Gli ecosistemi narrativi nello scenario mediale contemporaneo : spazi, modelli, usi sociali. Mucchi, 2013.

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Smith, Scott D., and Holly E. Gray. Surface Complexation Modelling and Aluminum Mediated Phosphorus: White Paper. IWA Publishing, 2015.

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Goldring, Steven R. Pathophysiology of periarticular bone changes in osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0005.

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Under physiological conditions, the subchondral bone of diarthrodial joints such as the hip, knee, and phalanges forms an integrated biocomposite with the overlying calcified and hyaline articular cartilage that is optimally organized to transfer mechanical load. During the evolution of the osteoarthritic process both the periarticular bone and cartilage undergo marked changes in their structural and functional properties in response to adverse biomechanical and biological signals. These changes are mediated by bone cells that modify the architecture and properties of the bone through active cellular processes of modelling and remodelling. These same biomechanical and biological factors also affect chondrocytes in the cartilage matrix altering the composition and structure of the cartilage and further disrupting the homeostatic relationship between the cartilage and bone. This chapter reviews the structural alterations and cellular mechanisms involved in the pathogenesis of osteoarthritis bone pathology and discusses potential approaches for targeting bone remodelling to attenuate the progression of the osteoarthritic process.
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Dacome, Lucia. Epilogue. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198736189.003.0009.

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The Epilogue traces a shift in attitude towards anatomical modelling. In the mid-eighteenth century anatomical models had been praised for their capacity to defy time in the sense that they both resisted the body’s physical decay and promised to provide lasting and timeless sources of corporeal knowledge. However, by the end of the century changing attitudes towards notions of authenticity and techniques of production caused some to doubt earlier anatomical models’ capacity to produce and mediate knowledge about the body. Anatomical modelling continued to be regarded as a useful and promising medical technique. Yet, by the end of the eighteenth century the very models that only a few decades earlier had fuelled much interest among both practitioners and lay audiences, had already started to slip into obsolescence.
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Dacome, Lucia. Malleable Anatomies. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198736189.001.0001.

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Malleable Anatomies examines the early stages of the practice of anatomical modelling. It investigates the ‘mania’ for anatomical displays that swept the Italian peninsula in the mid-eighteenth century, and traces the fashioning of anatomical models as important social, cultural, and political as well as medical tools. Anatomical models offered special insights into the inner body. Being coloured, soft, and malleable, they fostered anatomical knowledge in delightful ways. But how did anatomical models inscribe and mediate bodily knowledge? How did they change the way in which anatomical knowledge was created and communicated? And how did they affect the lives of those involved in their production, display, viewing, and handling? Examining the circumstances surrounding the making and early viewing of anatomical displays in Bologna, Naples, and Palermo, Malleable Anatomies addresses these questions by reconstructing how anatomical modelling developed at the intersection of medical knowledge, religious ritual, antiquarian and artistic cultures, and Grand Tour display. While doing so, it investigates the development of anatomical modelling in the context of the diverse visual and material practices that characterized the representation and display of the body. Drawing attention to the artisanal dimension of anatomical practice, and the role of women as both makers and users, it considers how anatomical models lay at the centre of a composite world of social interactions that led to the fashioning of modellers as anatomical celebrities. Moreover, it examines how anatomical displays transformed the proverbially gruesome practice of anatomy into an enthralling experience that engaged audiences’ senses and affects.
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Book chapters on the topic "Mediated modelling"

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Buck, Dorothy. "Reactions Mediated by Topoisomerases and Other Enzymes: Modelling Localised DNA Transformations." In Discrete and Topological Models in Molecular Biology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-40193-0_16.

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Darbre, T., V. Siljegovic, A. Amolins, et al. "Exploring Co-Mediated Organic Reactions. Modelling Molecular Recognition in Vitamin B12 Dependent Reactions." In Novel Trends in Electroorganic Synthesis. Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-65924-2_119.

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Remais, Justin. "Modelling Environmentally-Mediated Infectious Diseases of Humans: Transmission Dynamics of Schistosomiasis in China." In Advances in Experimental Medicine and Biology. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6064-1_6.

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Nilsen, Trude, Ronny Scherer, Jan-Eric Gustafsson, Nani Teig, and Hege Kaarstein. "Teachers’ Role in Enhancing Equity—A Multilevel Structural Equation Modelling with Mediated Moderation." In Equity, Equality and Diversity in the Nordic Model of Education. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-61648-9_7.

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AbstractEven though equity is an important aim for the Nordic countries, for many of these countries, the effect of a student’s home background on their achievement seems to increase over time. If the aim is to reduce the effect of SES (socioeconomic status) on student outcomes, there is a need to identify the factors that moderate this relation. One such factor could be teachers and their instruction because they have been found to be key to student outcomes. However, few have linked teachers and their instruction to equity, and fewer still have made this link in Nordic countries. The aim of the present study is to identify the aspects of teacher quality and their instruction that may reduce the relationship between SES and student achievement in the Nordic countries. Eighth-grade students from the only two Nordic countries participating in TIMSS 2015 (Norway and Sweden) were selected. Multigroup, multilevel (students and classes) structural equation models with random slopes were employed to investigate which aspects of teacher quality moderate the relation between SES and student science achievement via instructional quality. The findings show that teacher professional development and specialisation reduce the relation between SES and science achievement via instructional quality in Sweden, while there were no significant findings for Norway. This study contributes to the fields of equity and teacher effectiveness, demonstrating that teachers may make a difference in reducing inequity through their competence and instruction.
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Pahl-Wostl, Claudia. "Spatio-Temporal Organization Mediated by a Hierarchy in Time Scales in Ensembles of Predator-Prey Pairs." In Predictability and Nonlinear Modelling in Natural Sciences and Economics. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0962-8_22.

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Smørdal, Ole. "Objects@Work — An Activity Theoretical Framework for OO Modelling of Computer Mediated Cooperative Activities." In OOIS 2000. Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-0299-1_13.

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Patriarcheas, Kiriakos, Spyridon Papaloukas, and Michalis Xenos. "The Text-Based Computer-Mediated Communication in Distance Education Fora: A Modelling Approach Based on Formal Languages." In Intelligent Adaptation and Personalization Techniques in Computer-Supported Collaborative Learning. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28586-8_11.

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Logie, Carmen H., Ying Wang, Patrick Lalor, Kandasi Levermore, and Davina Williams. "Exploring the Protective Role of Sex Work Social Cohesion in Contexts of Violence and Criminalisation: A Case Study with Gender-Diverse Sex Workers in Jamaica." In Sex Work, Health, and Human Rights. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64171-9_5.

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AbstractBackground: Sex work social cohesion (SWSC) is associated with reduced HIV vulnerabilities, yet little is known of its associations with mental health or violence. This is particularly salient to understand among gender-diverse sex workers who may experience criminalisation of sex work and same-gender sexual practices. This chapter explores SWSC and its associations with mental health and violence among sex workers in Jamaica.Methods: In collaboration with the Sex Work Association of Jamaica (SWAJ) and Jamaica AIDS Support for Life, we implemented a cross-sectional survey with a peer-driven sample of sex workers in Kingston, Montego Bay, and Ocho Rios. Structural equation modelling (SEM) was conducted to examine direct and indirect effects of SWSC on depressive symptoms and violence (from clients, intimate partners, and police), testing the mediating roles of sex work stigma and binge drinking. SWAJ developed an in-depth narrative of the lived experiences of a sex worker germane to understanding SWSC.Results: Participants (N = 340; mean age: 25.77, SD = 5.71) included 36.5% cisgender men, 29.7% transgender women, and 33.8% cisgender women. SEM results revealed that SWSC had significant direct and indirect effects on depressive symptoms. Sex work stigma partially mediated the relationship between SWSC and depressive symptoms. The direct path from SWSC to reduced violence was significant; sex work stigma partially mediated this relationship.Implications: Strengths-focused strategies can consider the multidimensional role that social cohesion plays in promoting health and safety among sex workers to further support the ways in which sex workers build community and advocate for rights.
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Duell, Rob, and Jan Treur. "Modelling Mediator Assistance in Joint Decision Making Processes Involving Mutual Empathic Understanding." In Computational Collective Intelligence. Technologies and Applications. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-11289-3_55.

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Duell, Rob. "Modelling Mediator Intervention in Joint Decision Making Processes Involving Mutual Empathic Understanding." In Neural Information Processing. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-12640-1_71.

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Conference papers on the topic "Mediated modelling"

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Abdulla, T., J.-M. Schleich, and R. Summers. "Multiscale modelling of Notch-mediated lateral induction." In 2012 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE, 2012. http://dx.doi.org/10.1109/bhi.2012.6211560.

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Evans, Nick, and John Counsell. "Web-Mediated Student Peer Group Assessment of Building Information Modelling Performance." In 2009 Second International Conference in Visualisation (VIZ). IEEE, 2009. http://dx.doi.org/10.1109/viz.2009.34.

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Li, Jianrong, Tianle Cheng, and Martin Y. M. Chiang. "Finite Element Modelling of Cell Adhesion Mediated by Receptor-Ligand Binding." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206297.

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The process of cell adhesion and spreading on the extracellular matrix (ECM) protein layer is mediated by the interaction of cell receptors and ECM ligands [1]. Receptors diffuse along the cell membrane surface and interact with ligands in ECM to form bonds. Cells spread and the adhesion zone grows as bond formation at the adhesion front increases to a critical level. This process involves coupling of reaction-diffusion and mechanical contact between cells and ECM. In this study, a novel numerical algorithm is developed to implement this coupling into the finite element method for modeling the process of cell adhesion and spreading. By taking the mass diffusion and the user-defined gap conductance features provided in a commercial FEM code, Abaqus [2], the process has been solved in an integrated and fully coupled manner. Preliminary results have been obtained from the simulation of cell spreading on a rigid substrate. The influence of glycocalyx layer (present at cell surface) on the adhesion development has also been incorporated into the modeling.
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Romanenko, Sergii, Peter H. Siegel, Livia Hoola, Alan R. Harvey, and Vincent Wallace. "Modelling Neuronal Activity Alterations Caused by MMW- THz Mediated Melting of Lipid Membrane." In 2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2018). IEEE, 2018. http://dx.doi.org/10.1109/irmmw-thz.2018.8510054.

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Lamb, David, David Fairman, Radha Desai, et al. "Temporal Characterisation And Modelling Of Fluticasone Propionate-mediated 24 Hour AUC Corticosterone Suppression In Rats." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4262.

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Machin, M., A. Santomaso, M. Mazzucato, and P. Canu. "Kinetic and thermodynamic modelling of the von Willebrand factor mediated bonds during platelet adhesion under flow conditions." In BIOMEDICINE 2005. WIT Press, 2005. http://dx.doi.org/10.2495/bio050361.

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Dimitrakopoulou, D., D. Tulkens, T. Naert, P. Van Vlierberghe, and K. Vleminckx. "PO-206 Modelling T cell acute lymphoblastic leukaemia using CRISPR/Cas9 mediated genome editing in Xenopus tropicalis." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.724.

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8

Ismail, Shahrinaz, and Mohd Sharifuddin Ahmad. "A goal-based framework on contextual requirements modelling for agent-mediated continual quality improvement (aCQI) in curriculum design." In IMCOM '15: The 9th International Conference on Ubiquitous Information Management and Communication. ACM, 2015. http://dx.doi.org/10.1145/2701126.2701178.

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9

Duro, Lara, Abel Tamayo, Jordi Bruno, and Aurora Marti´nez-Esparza. "Modelling Radionuclide Mobility of Spent Fuel in a Deep Geological Repository Located in a Clay Bedrock." In ASME 2009 12th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2009. http://dx.doi.org/10.1115/icem2009-16240.

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Abstract:
Source term models are widely used to assess the behaviour of spent nuclear fuel after final disposal. However, most models do not take into account some phenomena which are expected to control the transport of radionuclides through the near field. Some uncertainties arise from this fact, thus making it difficult to obtain proper simulations of radionuclide behaviour in the near field. In this work, we have used a compartmental code to build up an integrated source term model in an attempt to overcome the abovementioned drawbacks. The model developed takes into account radiolytically-mediated matrix dissolution, radioactive decay chains, diffusive transport, and retardation by sorption and secondary phase precipitation, among other processes. In addition, this model has been used to estimate radionuclide mobility from spent fuel located in a conceptual clay geological repository.
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Ning, Shengwei, and Huirong Cao. "Family Intimacy and Social Support Mediate the Relationship between National Identity and Cultural Alienation among Adolescents of Li Nationality." In 2017 2nd International Conference on Modelling, Simulation and Applied Mathematics (MSAM2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/msam-17.2017.51.

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