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Journal articles on the topic 'Mediatext'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Snikhovska, Irena. "LUDIC STRATEGIES IN MODERN ENGLISH-LANGUAGE MEDIATEXT." Odessa linguistic journal 11 (2018): 71–77. http://dx.doi.org/10.32837/2312-3192-2018-11-71-77.

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2

Prom, Natalia Alexandrovna. "ADDRESSEE ADAPTATION OF A MEDIATEXT." Crede Experto: Transport, Society, Education, Language, no. 4 (2021): 136–48. http://dx.doi.org/10.51955/2312-1327_2021_4_136.

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3

Tayupova, O. I. "Advertising as a type of mediatext." Rossiiskii Gumanitarnyi Zhurnal 6, no. 5 (2017): 435. http://dx.doi.org/10.15643/libartrus-2017.5.9.

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4

Kolesnikova, O. I., and E. V. Voronova. "COGNITIVE-PRAGMATIC BASIS FOR EDITING MEDIATEXT." Voprosy Kognitivnoy Lingvistiki, no. 1 (2019): 75–81. http://dx.doi.org/10.20916/1812-3228-2019-1-75-81.

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5

Kalinin, O. I. "REVISITING THE «IMAGE-BUILDING POLITICAL MEDIATEXT» DEFINITION." Vektor nauki Tol'yattinskogo gosudarstvennogo universiteta, no. 3-2 (2015): 193–98. http://dx.doi.org/10.18323/2073-5073-2015-3-193-198.

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6

Achylova, O. L., and I. A. Rehushevska. "MEDIATEXT AS A MIRROR OF MODERN SOCIETY." Тrаnscarpathian Philological Studies 1, no. 28 (2023): 23–27. http://dx.doi.org/10.32782/tps2663-4880/2023.28.1.4.

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7

Sokolova, Olga Leonidovna, and Ludmila Valentinovna Skopova. "PARCELLING IN RUSSIAN AND FRENCH MEDIATEXT: CORPUS ANALYSIS." Политическая лингвистика, no. 6 (2018): 160–65. http://dx.doi.org/10.26170/pl18-06-23.

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8

Uvarova, E. "MEDIATEXT AND MEDIADISCOURSE: THE PROBLEM OF THEIR CORRELATION." Bulletin of the Moskow State Regional University, no. 5 (2015): 47–54. http://dx.doi.org/10.18384/2310-712x-2015-5-47-54.

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9

Shestakova, Eleonora G. "Paradoxes of modern mediatext in the context of semiotics methodology." Media Linguistics 6, no. 2 (2019): 180–95. http://dx.doi.org/10.21638/spbu22.2019.203.

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10

Karagodin, A. A., and I. A. Karagodina. "MEDIATEXT WITH HIDDEN INFORMATION AS OBJECT OF A LINGUISTICEXPERT INVESTIGATION." Culture and Text, no. 42 (2020): 126–39. http://dx.doi.org/10.37386/2305-4077-2020-3-126-139.

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11

Uvarova, E. A. "Iconic Component of the Polycode Mediatext and Its Stylistic Potential." Prepodavatel XXI vek, no. 2, 2020 (2020): 380–92. http://dx.doi.org/10.31862/2073-9613-2020-2-380-392.

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The article considers various peculiarities of implementing stylistic devices (metaphor, gradation, personification, contrast) in the advertising poly-code media text that, in its turn, serves as the object of the research. The research proves that the realization of stylistic devices can be actualized not only on the basis of the close correlation of iconic and verbal components (integration or extension relationships), but also within the structure of the iconic component independently and without any verbal elements. The author searches out that the notion of the stylistic device can be exp

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12

Kirillova, N. B. "Mediatext Language Practices as a Factor in Representation of Reality." Journal of Flm Arts and Film Studies 9, no. 3 (2017): 98–109. http://dx.doi.org/10.17816/vgik9398-109.

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The article deals with the theoretical aspects of mediaculture as a sign system with reference to its historic development. The media language as a complex of sign systems (texts) evolved from object script to written language, from text copying (bookprinting) to electronic mediaculture, its visual, audial and audiovisual (screen) kinds. Contemporary me-diaculture that represents reality by means of a screen is related to the frame aesthetics. It is the screen culture that integrates and synthesizes all the previous sign systems due to the fact that new media is a result of technical progress.

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13

Syzonov, Dmytro. "A phraseologism-heading as a manipulative dominant of a mediatext." Actual issues of Ukrainian linguistics: theory and practice, no. 40 (2020): 58–70. http://dx.doi.org/10.17721/apultp.2020.40.58-70.

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The article deals with different types of headings with a phraseological component, which is motivated by the manipulative function of media. Thus, journalists resort to manipulation in media when they want to: (a) obscure factual information; (b) affect the mass consciousness of the Ukrainians; (c) focus on key positions of a media text. A phraseologism (as a certain verbal code of mass communication that is characterized by semantic indivisibility, integrity, emotionality and expressiveness) is used primarily to attract the attention of the recipient and to accentuate the main positions of a

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14

Gadzhieva, A. M. "ADEQUACY OF MEDIATEXT TRANSLATION WITH THE HELP OF ELECTRONIC TRANSLATORS." Форум молодых ученых, no. 5 (2021): 104–11. http://dx.doi.org/10.46566/2500-4050_2021_57_104.

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15

Лешутина, И. А., and Н. Лисовая. "MEDIATEXT: EDUCATIONAL APPROACHES TO TEACHING RUSSIAN AS A FOREIGN LANGUAGE." Russkii iazyk za rubezhom, no. 6(289) (January 14, 2022): 21–26. http://dx.doi.org/10.37632/pi.2021.289.6.004.

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В статье описаны итоги анализа научных публикаций исследователей РКИ и цифровой лингводидактики о медиатекстах и их использовании на уроках РКИ с точки зрения медиаобразовательного подхода. Осмыслена роль медианавыков и знаний журналистских жанров преподавателями РКИ и учащимися в работе с медиатекстами как учебными, дидактическими материалами. Дано обоснование необходимости журналистского подхода к изучению медиатекстов с целью эффективного и продуктивного использования жанров средств массовой информации и коммуникации на занятиях по РКИ. The article describes the results of the analysis of s

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16

Toropkina, V. A. "DERIVATIONAL METHODS OF SOCIAL EVALUATIVITY EXPRESSION IN THE MODERN MEDIATEXT." Russian language at school 79, no. 5 (2018): 67–71. http://dx.doi.org/10.30515/0131-6141-2018-79-5-67-71.

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17

Yakhyayeva, Navruza. "MEDIATEXT IS A TOOL THAT DETERMINES THE QUALITY OF INFORMATION." INTERNATIONAL JOURNAL OF WORD ART 6, no. 3 (2020): 158–64. http://dx.doi.org/10.26739/2181-9297-2020-6-22.

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The quality and content of information in the article media text is based on scientific classification of linguistic features. The study of functional styles of speech, the identification of their linguistic signs, the discovery of the functional properties of linguistic units and their separation on the basis of linguistic facts is one of thetasks that modern linguistics is waiting for a solution. Text Linguistics, which deals with the creation, modeling of its structure and the study of the process of such activity, is of interest to journalists today as a science.

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18

Vereshinskaya, Yu V. "The classification of newspaper headlines in Spanish journalist discourse." Cuadernos Iberoamericanos, no. 2 (June 28, 2015): 67–71. http://dx.doi.org/10.46272/2409-3416-2015-2-67-71.

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The article reviews the different classifications of the Spanish newspaper headlines that were offered by the Spanish linguists. They consider the headline a component of the mediatext that reproduces completely or partly the elements of the text of the article. These investigations concern such areas of linguistics as media linguistics, pragmalinguistics, functional linguistics, theory of the text.

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19

Kon’kov, Vladimir I., and Huejcin’ Chzhan. "Functional verb specificity in the report." Media Linguistics 7, no. 4 (2020): 409–17. http://dx.doi.org/10.21638/spbu22.2020.403.

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The work analyzes the functionality of the Russian verb in the genre of information reporting. The use of the verb in the form of this actual (real reportage) is considered one of the main features of the genre of reporting. However, the analysis shows that along with the forms of the present topical in the report are actively used forms of verbs of the past time of imperfect kind. The authors pay attention to the functional identity of these verb forms. The present reportage (real topical) can only be formed from the verbs of an imperfect kind. It is the imperfect ap pearance of the verb that

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20

Kalenych, Volodymyr. "Intertextuality of the headline complexes in mediatexts." Current issues of Ukrainian linguistics: theory and practice, no. 44 (2022): 130–46. http://dx.doi.org/10.17721/apultp.2022.44.130-146.

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The article deals with the functional-stylistic and communicative-pragmatic features of intertextuality in headline complexes and their compositional role in the modern mediatexts (based on the publications of the information-analytical weekly "Dzerkalo tyzhnya"). Intertext is a cognitive-communicative category and a text-forming element, which implements the author's idea. The intertextual techniques are used in the main headings, subheadings, inner headings, epigraphs, leads. They serve to pay attention to the problem, to express the attitude and leading opinion of the publication, to draw p

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21

Chekunova, Marina A. "ON GENRE NATURE OF THE MEDIATEXT OF THE POLITICAL-ADMINISTRATIVE BLOGOSPHERE." Bulletin of the Moscow State Regional University (Russian philology), no. 3 (2017): 41–49. http://dx.doi.org/10.18384/2310-7278-2017-3-41-49.

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22

Kuznietsova, T. V. "THE COMMUNICATIVE-CONCEPTUAL APPROACH AS THE BASIC FOR AXIOLOGICAL STUDY OF MEDIATEXT." Scientific notes of Taurida National V.I. Vernadsky University, series Philology. Social Communications 4, no. 2 (2020): 208–15. http://dx.doi.org/10.32838/2663-6069/2020.2-4/32.

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23

Basko, N. V. "Modern mediatext in the aspect of culturology: figurative names of geographical objects." Belgorod State University Scientific bulletin Series Humanities 37, no. 4 (2018): 573–82. http://dx.doi.org/10.18413/2075-4574-2018-37-4-573-582.

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24

Raskhodchikov, A. N., and M. A. Pilgun. "HOW IMAGES OF ECOLOGY IN NETWORK MEDIATEXT ARE CATALYSTS OF URBAN CONFLICTS." Речевые технологии, no. 3-4 (2020): 54–72. http://dx.doi.org/10.58633/2305-8129_2020_3-4_54.

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25

Lomakin, Boris Ye. "LINGUO-MEDIAL RECONSTRUCTION OF AN EVENT IN CROSS-CULTURAL ASPECT: HOW MEDIA-TEXTS FROM LE MONDE ARE TRANSLATED INTO ENGLISH." HUMANITIES AND SOCIAL STUDIES IN THE FAR EAST 20, no. 1 (2023): 195–203. http://dx.doi.org/10.31079/1992-2868-2023-20-1-195-203.

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The article investigates some characteristic features of translation strategy applied by translators from Le Monde for rendering French media-texts into English. It reveals that during translation process pragmatic adaptation is often applied. Mediatext as a whole and its title and lead in particular are subjected to numerous transformations including division of one sentence into several and deliberate omission of some pieces of information. Consequentially, some differences can be observed between the images of the same event depicted in the original text and its translation.

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26

Gorshkov, Sergey Yurievich. "MEDIATEXT AS A STRUCTURE-FORMING UNIT OF THE INFORMATION PICTURE OF THE WORLD." Economy, Governance and Lave Basis, no. 5 (2021): 10–12. http://dx.doi.org/10.51608/23058641_2021_5_10.

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27

Легостаева, Е. А. "Политическая медиаметрия как методика определения степени агрессивности информационной среды". Information Age 7, № 1(22) (2023): 71–80. https://doi.org/10.33941/2618-9291.2023.22.1.008.

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В статье рассматривается методика политической медиаметрии как способ качественно-количественного анализа медиатекстов. Данная методика позволяет оценить степень агрессивности информационной среды, отражающую взаимоотношения двух и более государств в медиапространстве. В рамках статьи исследуется взаимосвязь понятия тональности текста с такой функциональной семантико-стилистической категорией медиатекста, как оценочность. The article is devoted to the usage of political media metrics as a method of qualitative and quantitative analysis of mediatext. This method allows us to evaluate the level

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28

Dоmina, Victoriia. "THE ISSUE OF FORMING MEDIA LITERACY OF FUTURE TRANSLATORS." Scientific journal of Khortytsia National Academy, no. 2 (2020): 119–26. http://dx.doi.org/10.51706/2707-3076-2020-2-12.

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The globalization of the modern information world has led to the adoption of media culture in virtually all areas of human life – manufacturing, the public sphere, education, communication, and the arts. Media connections are formed between all social structures, countries, different communities. It is through mass communication that the process of rooting values and behaviors that dominate society at a certain time takes place. In the proposed article, the author argues that at the present stage particular importance is gained by the involvement of an individual in the media culture in the co

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29

Ponomarenko, I. N., V. A. Kryzhanovskaya, and N. A. Segal. "ASYMMETRICAL BASIS OF THE ANTITHESIS WITH THE OPPOSITION SELF / OTHER IN MODERN MEDIATEXTS." Voprosy Kognitivnoy Lingvistiki, no. 3 (2020): 111–16. http://dx.doi.org/10.20916/1812-3228-2020-3-111-116.

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The article analyzes the asymmetrical basis of the antithesis with the opposition self / other in modern mediatexts. The aim is to state and interpret the peculiar linguistic realization of the asymmetrical basis of the antithesis with the opposition self / other in modern mediatexts. The study systematizes theoretical statements arguing asymmetrical relations as basic characteristics of language and text. Besides, it proves dominating role of asymmetry in modelling Russian media space. The article highlights that media discourse asymmetry, which became the object of scientific research only i

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30

Filichkina, T. P. "Synchronism and diachronism of antique origin idioms in the English language media discourse." Linguistics & Polyglot Studies 8, no. 2 (2022): 53–62. http://dx.doi.org/10.24833/2410-2423-2022-2-31-53-62.

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The article examines the semantics of idioms of antique origin in media discourse from the standpoint of synchrony and diachrony. The study of media discourse as a phenomenon of language and as an extralinguistic entity enables us to consider it using methods of cognitive and discourse analyses. Phraseological units as inherent elements of mediatexts have a powerful connotative (evaluative) potential at the synchronic level that is identified by referring to the source of the expression at the diachronic level. Cognitive analysis determines the evaluative potential in the semantics of idioms a

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31

남지애. "A Case Study on Leaners’ Experiences of MediaText Production - Focusing on high school students’ experiences in making UCC -." Journal of Korean Language Education ll, no. 32 (2013): 1–40. http://dx.doi.org/10.17313/jkorle.2013..32.1.

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32

Kalenych, Volodymyr. "Cognitive and Communicative Pragmatic Parameters of Intertextuality in Mass Media." PSYCHOLINGUISTICS 27, no. 2 (2020): 155–73. http://dx.doi.org/10.31470/2309-1797-2020-27-2-155-173.

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Objective. The main objective of this research is to analyse the cognitive and communicative-pragmatic parameters of intertextuality in modern mediatexts. The article deals with the peculiarities of intertextuality expression in mass media as well as identifies the main varieties of intertexts and considers their role in newspaper articles of the information-analytical weekly “Dzerkalo tyzhnya”. Research methods. Discourse analysis technique helped to identify textual and extratextual characteristics of media content. At various stages of the study, a functional analysis method is used t

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33

Filichkina, T. P. "Modern Russia in focus of phraseology (based on the material of english language mediatexts)." Philology at MGIMO 23, no. 3 (2020): 63–71. http://dx.doi.org/10.24833/2410-2423-2020-3-23-63-71.

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The article focuses on the usage of idioms for characterizing the image of Russia in the English language media discourse. To understand the meaning of the phraseological unit one should apply the method of discourse analysis. The discourse analysis of the mediatext takes into account extra-linguistic, linguistic and cognitive factors. Extra-linguistic factors include political situation, current events, and ideology of a state and media outlet. Linguistic analysis provides for the investigation of the semantics of the idiom and its connotative potential. Cognitive analysis shows the intention

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34

Bezrodnykh, Irina, and Olena Konopelkina. "POLITICAL METAPHOR AS A MEANS OF LINGUISTIC REPRESENTAION OF DONALD TRUMP’S IMAGE IN MASS MEDIA." English and American Studies 1, no. 17 (2020): 10–16. http://dx.doi.org/10.15421/382002.

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The article under discussion has focused on the peculiarities the conceptual metaphor usage in the speeches of the 45th and current president of the United States Donald Trump. The topicality of the investigation is predetermined by the steady increase of professional interest of political discourse participants, mass media in particular, in the choice of effective instruments of political and ideological relations coverage with a simultaneous public request for quality of the politically directed content. The differentiation of political metaphor features and its functions in publicistic disc

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35

Abbasova, Bulbul. "Functional Peculiarities of Culturonyms in The Context Of Political Media Discourse." Acta Globalis Humanitatis et Linguarum 1, no. 2 (2024): 155–61. https://doi.org/10.69760/aghel.01024077.

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The workings of culturally influenced language indicators in political mass media are revealed in this essay. The way that culturally marked linguistic signs are used in political conversation has some quirks that enable them to accomplish the objectives that political communication sets. The political communication tasks, on the one hand, determine the reality that culturally marked units actively participate in political debate. However, these objectives and activities align with the ontological characteristics of these signals. These characteristics include the axiogeneity of linguistic sig

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36

Dobrosklonskaya, T., and Polina Loginova. "Political Media Rhetoric: an Integrated Approach to The Study of Speech Practices in Political Media Discourse." Scientific Research and Development. Modern Communication Studies 12, no. 4 (2023): 47–54. http://dx.doi.org/10.12737/2587-9103-2023-12-4-47-54.

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The article outlines a new integrated approach to the study of political media communications, represented as a separate discipline — political media rhetoric. The academic demand for media rhetoric as a new branch of media linguistic and rhetoric studies is determined by the growing interest to the rhetoric aspect of political media discourse and hence the necessity of introducing a complex systemic approach to its analysis. The theory of political media rhetoric is constructed on the basis of key assumptions of classical rhetoric, media linguistics, media stylistics and other disciplines rel

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37

Beloedova, Anna V., Nadezhda N. Khukhryanskaya, Ekaterina A. Novinkina, Marina Yu Pitinova, and Yuliya N. Shatalova. "Representation of Femininity: Grammatical Aspect (Cosmopolitan, Marie Claire and Glamour Magazines)." Journal of History Culture and Art Research 6, no. 5 (2017): 200. http://dx.doi.org/10.7596/taksad.v6i5.1280.

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<p>The paper features the language objectivation of femininity in the glossy magazines Cosmopolitan, Marie Claire and Glamour. The analysis of the problem is based on the theory of the social construction of gender and aims to identify the main trends of language representation of women. The material of the study was Russian Publications Cosmopolitan, Marie Claire and Glamor - the most popular glossy magazines designed for women. The files of the examples analyzed by us are compiled by the method of continuous sampling (more than 2000 contexts) on the basis of printed and Internet versio

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38

Tanjung, Jennifer Katherine, Rubiyatno, and Lucia Kurniawati. "THE INFLUENCE OF WEBSITE QUALITY, PERCEIVED BENEFITS, E-WOM, SECURITY TOWARDS ONLINE REPURCHASE INTEREST WITH TRUST AS THE MEDIATING VARIABLE." MANAJEMEN DEWANTARA 6, no. 3 (2022): 268–80. http://dx.doi.org/10.26460/md.v6i3.13190.

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This study aims to find out whether: 1) trust mediates the influence of website quality toward repurchase interest, 2) trust mediates the influence of the perceived benefits toward repurchase interest, 3) trust mediates E-WOM's influence toward repurchase interest, 4) trust mediates security influence toward repurchase interest, in Lazada consumers in Yogyakarta. The population in this study are the locals of Yogyakarta community who had made an online purchase at Lazada. The sampling technique used purposive sampling, data was obtained by distributing online questionnaires by using google for

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39

Bligard, Gregory W., James DeBrecht, Robert G. Smith, and Peter D. Lukasiewicz. "Light-evoked glutamate transporter EAAT5 activation coordinates with conventional feedback inhibition to control rod bipolar cell output." Journal of Neurophysiology 123, no. 5 (2020): 1828–37. http://dx.doi.org/10.1152/jn.00527.2019.

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Excitatory amino acid transporter 5 (EAAT5) glutamate transporters have a chloride channel that is strongly activated by glutamate, which modulates excitatory signaling. We found that EAAT5 is a major contributor to feedback inhibition on rod bipolar cells. Inhibition to rod bipolar cells is also mediated by GABA and glycine. GABA and glycine mediate the early phase of feedback inhibition, and EAAT5 mediates a more delayed inhibition. Together, inhibitory transmitters and EAAT5 coordinate to mediate feedback inhibition, controlling neuronal output.

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40

Shao, Yufang, Wendy Akmentin, Juan Jose Toledo-Aral, et al. "Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes." Journal of Cell Biology 157, no. 4 (2002): 679–91. http://dx.doi.org/10.1083/jcb.200201063.

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Acentral tenet of nerve growth factor (NGF) action that is poorly understood is its ability to mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve terminal and conveyed to the soma. We identified an NGF-induced protein that we termed Pincher (pinocytic chaperone) that mediates endocytosis and trafficking of NGF and its receptor TrkA. In PC12 cells, overexpression of Pincher dramatically stimulated NGF-induced endocytosis of TrkA, unexpectedly at sites of clathrin-independent macropinocytosis within cell surface ruffles. Subsequently, a system of Pincher-con

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41

Bournazos, Stylianos, David J. DiLillo та Jeffrey V. Ravetch. "The role of Fc–FcγR interactions in IgG-mediated microbial neutralization". Journal of Experimental Medicine 212, № 9 (2015): 1361–69. http://dx.doi.org/10.1084/jem.20151267.

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Antibodies are bifunctional molecules, containing a variable Fab domain that mediates binding specificity and a constant Fc domain that bridges antibody-coated targets with FcγR-expressing cells that mediate effector functions. Although traditional mechanisms of antibody-mediated neutralization of microbes have been largely thought to result from Fab–antigen interactions, recent studies suggest that recruitment of FcγR-expressing effector cells by antibodies is a major in vivo mechanism of antibody-mediated protection from infection. In this article, we review FcγR biology, compare mammalian F

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42

Guarnieri, Adrienne R., Sarah R. Anthony, Anamarie Gozdiff, et al. "Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis." American Journal of Physiology-Heart and Circulatory Physiology 321, no. 1 (2021): H228—H241. http://dx.doi.org/10.1152/ajpheart.00957.2020.

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The presence of functional brown adipose tissue in humans is known to be associated with cardiovascular health. Here, we show that adipocyte-specific deletion of the RNA binding protein HuR, which we have previously shown to reduce BAT-mediated thermogenesis, is sufficient to mediate a spontaneous development of cardiac hypertrophy and fibrosis. These results may have implications on the mechanisms by which BAT function and adipose tissue homeostasis directly mediates cardiovascular disease.

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43

Werner, C. T., S. Mitra, J. A. Martin, et al. "Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving." Science Advances 5, no. 10 (2019): eaay0351. http://dx.doi.org/10.1126/sciadv.aay0351.

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Neuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving that intensifies (“incubates”) during abstinence and is believed to contribute to persistent relapse vulnerability. Changes in gene expression often govern perpetual behavioral abnormalities, but epigenetic plasticity during prolonged abstinence from drug exposure is poorly understood. We examined how E3 ubiquitin ligase TRIM3 dysregulates chromatin remodeler INO80 to mediate cocaine craving during prolonged abstinence. We found that INO80 expression increased in the NAc on abstinence day 30 (AD30) but not on

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44

Xing, Luzhou, Chang Ge, Ross Zeltser, Gregory Maskevitch, Bruce J. Mayer, and Konstantina Alexandropoulos. "c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase." Molecular and Cellular Biology 20, no. 19 (2000): 7363–77. http://dx.doi.org/10.1128/mcb.20.19.7363-7377.2000.

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ABSTRACT Oncogenic Src proteins have been extensively studied to gain insight into the signaling mechanisms of Src. To better understand signaling through wild-type Src, we used an approach that involves activation of Src signaling through the binding of physiologic ligands to the Src SH3 domain. To this end, we used full-length and truncated versions of the multiadapter molecules Cas and Sin to activate c-Src, and we examined the intracellular pathways that mediate Src signaling under these conditions. We show that although all proteins bind to and are phosphorylated by c-Src, quantitative di

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Suetsugu, Noriyuki, Atsushi Takemiya, Sam-Geun Kong, et al. "RPT2/NCH1 subfamily of NPH3-like proteins is essential for the chloroplast accumulation response in land plants." Proceedings of the National Academy of Sciences 113, no. 37 (2016): 10424–29. http://dx.doi.org/10.1073/pnas.1602151113.

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In green plants, the blue light receptor kinase phototropin mediates various photomovements and developmental responses, such as phototropism, chloroplast photorelocation movements (accumulation and avoidance), stomatal opening, and leaf flattening, which facilitate photosynthesis. In Arabidopsis, two phototropins (phot1 and phot2) redundantly mediate these responses. Two phototropin-interacting proteins, NONPHOTOTROPIC HYPOCOTYL 3 (NPH3) and ROOT PHOTOTROPISM 2 (RPT2), which belong to the NPH3/RPT2-like (NRL) family of BTB (broad complex, tramtrack, and bric à brac) domain proteins, mediate p

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Thyagarajan, Bhaskar, Eric C. Olivares, Roger P. Hollis, Daniel S. Ginsburg та Michele P. Calos. "Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase". Molecular and Cellular Biology 21, № 12 (2001): 3926–34. http://dx.doi.org/10.1128/mcb.21.12.3926-3934.2001.

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ABSTRACT We previously established that the phage φC31 integrase, a site-specific recombinase, mediates efficient integration in the human cell environment at attB and attP phage attachment sites on extrachromosomal vectors. We show here that phageattP sites inserted at various locations in human and mouse chromosomes serve as efficient targets for precise site-specific integration. Moreover, we characterize native “pseudo”attP sites in the human and mouse genomes that also mediate efficient integrase-mediated integration. These sites have partial sequence identity to attP. Such sites form nat

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Yun, Jiyoung, Robert Saddawi-Konefka, Benjamin Goldenson, et al. "CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma model." Journal for ImmunoTherapy of Cancer 12, no. 5 (2024): e007187. http://dx.doi.org/10.1136/jitc-2023-007187.

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BackgroundNatural killer (NK) cells are key effector cells of antitumor immunity. However, tumors can acquire resistance programs to escape NK cell-mediated immunosurveillance. Identifying mechanisms that mediate this resistance enables us to define approaches to improve immune-mediate antitumor activity. In previous studies from our group, a genome-wide CRISPR-Cas9 screen identified Charged Multivesicular Body Protein 2A (CHMP2A) as a novel mechanism that mediates tumor intrinsic resistance to NK cell activity.MethodsHere, we use an immunocompetent mouse model to demonstrate that CHMP2A serve

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Jung, Hyun Jun, Sang-Yeob Kim, Hyo-Jung Choi та ін. "Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells". American Journal of Physiology-Renal Physiology 308, № 5 (2015): F473—F486. http://dx.doi.org/10.1152/ajprenal.00052.2014.

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Aquaporin-2 (AQP2) mediates arginine vasopressin (AVP)-induced water reabsorption in the kidney collecting duct. AVP regulates AQP2 expression primarily via Gsα/cAMP/PKA signaling. Tankyrase, a member of the poly(ADP-ribose) polymerase family, is known to mediate Wnt/β-catenin signaling-induced gene expression. We examined whether tankyrase plays a role in AVP-induced AQP2 regulation via ADP-ribosylation of G protein-α (Gα) and/or β-catenin-mediated transcription of AQP2. RT-PCR and immunoblotting analysis revealed the mRNA and protein expression of tankyrase in mouse kidney and mouse collecti

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Nishita, Michiru, Sa Kan Yoo, Akira Nomachi, et al. "Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration." Journal of Cell Biology 175, no. 4 (2006): 555–62. http://dx.doi.org/10.1083/jcb.200607127.

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The receptor tyrosine kinase Ror2 plays important roles in developmental morphogenesis. It has recently been shown that Ror2 mediates Wnt5a-induced noncanonical Wnt signaling by activating the Wnt–JNK pathway and inhibiting the β-catenin–TCF pathway. However, the function of Ror2 in noncanonical Wnt signaling leading to cell migration is largely unknown. We show, using genetically different or manipulated cultured cells, that Ror2 is critical for Wnt5a-induced, but not Wnt3a-induced, cell migration. Ror2-mediated cell migration requires the extracellular cysteine-rich domain (CRD), which is th

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Rezazadeh, Sarallah, David Yang, Gregory Tombline, et al. "SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170." Nucleic Acids Research 47, no. 15 (2019): 7914–28. http://dx.doi.org/10.1093/nar/gkz528.

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Abstract SIRT6 is critical for activating transcription of Nuclear factor (erythroid-derived 2)-like 2 (NRF2) responsive genes during oxidative stress. However, while the mechanism of SIRT6-mediated silencing is well understood, the mechanism of SIRT6-mediated transcriptional activation is unknown. Here, we employed SIRT6 separation of function mutants to reveal that SIRT6 mono-ADP-ribosylation activity is required for transcriptional activation. We demonstrate that SIRT6 mono-ADP-ribosylation of BAF170, a subunit of BAF chromatin remodeling complex, is critical for activation of a subset of N

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