Relevant bibliographies by topics / Mediation analysi

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  1. Journal articles
  2. Dissertations / Theses
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Academic literature on the topic 'Mediation analysi'

Author: Grafiati
Published: 22 February 2023

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Journal articles on the topic "Mediation analysi"

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Gonzalez, Oscar, and David P. MacKinnon. "A Bifactor Approach to Model Multifaceted Constructs in Statistical Mediation Analysis." Educational and Psychological Measurement 78, no. 1 (October 14, 2016): 5–31. http://dx.doi.org/10.1177/0013164416673689.

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Statistical mediation analysis allows researchers to identify the most important mediating constructs in the causal process studied. Identifying specific mediators is especially relevant when the hypothesized mediating construct consists of multiple related facets. The general definition of the construct and its facets might relate differently to an outcome. However, current methods do not allow researchers to study the relationships between general and specific aspects of a construct to an outcome simultaneously. This study proposes a bifactor measurement model for the mediating construct as a way to parse variance and represent the general aspect and specific facets of a construct simultaneously. Monte Carlo simulation results are presented to help determine the properties of mediated effect estimation when the mediator has a bifactor structure and a specific facet of a construct is the true mediator. This study also investigates the conditions when researchers can detect the mediated effect when the multidimensionality of the mediator is ignored and treated as unidimensional. Simulation results indicated that the mediation model with a bifactor mediator measurement model had unbiased and adequate power to detect the mediated effect with a sample size greater than 500 and medium a- and b-paths. Also, results indicate that parameter bias and detection of the mediated effect in both the data-generating model and the misspecified model varies as a function of the amount of facet variance represented in the mediation model. This study contributes to the largely unexplored area of measurement issues in statistical mediation analysis.
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Martin, Aran. "International mediation in low intensity conflicts." International Journal of Conflict Management 27, no. 4 (October 10, 2016): 505–22. http://dx.doi.org/10.1108/ijcma-07-2015-0043.

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Purpose Success and failure in mediation are widely understood to determine whether a state will receive positive or negative reputation outcomes from undertaking a mediation role in an international conflict. Research from mediation in domestic settings contradicts this view, finding that peer mediators in school and community settings received positive mediator outcomes from undertaking their role, even when they failed to facilitate an agreement between disputants. This paper aims to test this assumption and argues that mediation success and failure are only weakly correlated with observable reputation outcomes for mediating states and proposes an alternative explanatory framework. Design/methodology/approach The hypothesis was inductively generated through a comparative analysis of single-state mediation attempts selected from the Uppsala Conflict Database Project MILC data set. The cases selected were South Africa’s mediation attempts in Côte d’Ivoire from 2004 to 2005 and Comoros from 2003 to 2004, and Mexico’s mediation attempts in Colombia (National Liberation Army) in 2004 and Guatemala (Guatemalan National Revolutionary Unity) between 1994 and 1996. To contextualise the findings and develop the explanatory framework, South African mediation attempts in Burundi and the DRC are discussed in the closing sections of the paper. Findings This paper finds that mediation success and failure are only weakly correlated with mediator outcomes. Mediator outcomes are explained by the activity level of the mediating state in providing mediation services; the positive intention of the mediator to assist in resolving the conflict; the scale of the conflict mediated; the severity of spill over effects from the conflict in question; the regional importance of the conflict; the proximity of the government which a mediating state looks to develop relations with to the conflict; the importance of the mediation attempt within the peace process; the level of contestation of the mediation attempt, meaning the extent to which mediation attempts are themselves sites of regional or global international power politics; and the success or failure of the mediation attempt. Originality/value An explanatory framework for state mediator outcomes in which the outcome of a mediation attempt for the third-party state is not determined solely, or even primarily, by mediation success or failure bridges mediation research applying to international and domestic issue areas and provides additional information for policy makers regarding the costs and benefits of committing their state to processes of mediation in conflicts with low probabilities of resolution. This is particularly important for state policy makers, given that mediation is successful on average in only one out of every three attempts.
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Kaufman, Ruth. "The Process of Experiencing Mediated Learning as a Result of Peer Collaboration Between Young Adults With Severe Learning Difficulties." Journal of Cognitive Education and Psychology 5, no. 2 (January 2005): 215–16. http://dx.doi.org/10.1891/194589505787382540.

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Mediated learning is an interpersonal experience in which the mediator’s role is to develop in the mediatee functions essential for learning. The mediator focuses on the mediatee while identifying, analyzing, formulating, and solving problems related to everyday life and formal education frameworks. This study was focused upon the mediators, their experience in mediated learning, and the development of mediational abilities and cognitive functions as a result of social goals.Mediation was carried out in pairs and in a group format. The group was composed of low-functioning young adults suffering from severe learning problems. They acted in pairs, using a peer mediating activity, and also worked in the group to replicate their actions as well as to study the theory of mediated learning, its procedure, and its activities. The tasks were taken from Feuerstein’s cognitive intervention program, Instrumental Enrichment.Such a framework allowed me to identify and capture different aspects of students’ cognitive functioning as well as their inter- and intrapersonal mediation. Each student had to play different roles, sometimes acting as mediator to another member of the group, and thus focusing on his/her difficulties and needs, and at other times being a mediatee and receiving mediation from another group member. In addition, each student participated in the whole group activity reflecting upon, analyzing, and evaluating his/her own and his/her peer’s actions as well as those of others in the group. All this promoted strong experience in mediated learning, in different distances and modalities. Three different instruments were developed as a means of data collection and analysis: the mediation circular profile, the structural hierarchy of deficient cognitive functions map, and the process analysis flow chart.The study unfolded as a microdevelopmental process with students starting at a very low level of cognitive functioning and mediational ability and gradually progressing toward quite sophisticated methods of interaction, mediation, and problem solving. In the course of such microevolution, each group member developed his/her own position and role within the group and in the group activities.The findings support the theory of Structural Cognitive Modifiability while showing that even low-functioning people, who usually play the role of mediatee, can be mediators. By mediating to other people, they improve their own cognitive functioning, abstract level of thinking, and social and communication skills.
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Aini, Nurul, and Akhmad Zainuddin. "The Mediating Role of Good Corporate Governance on the Relation between Intellectual Capital and Financial Performance." IJEBD (International Journal of Entrepreneurship and Business Development) 6, no. 1 (January 31, 2023): 36–46. http://dx.doi.org/10.29138/ijebd.v6i1.2084.

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Purpose: This study aims to examine the role of good corporate governance (board of directors and board of commissioners) in mediating the bond between intellectual capital and financial performance. Design/methodology/approach: This study obtains data from 264 manufacturing companies listed on the Indonesia Stock Exchange in the 2015 – 2020 period. This study employs the Warp PLS 7.0 program. The tested research model is the multiple mediator model, with more than one mediating variables, so it requires multiple mediation analysis. Findings: The results reveal that intellectual capital has no effect on financial performance. Intellectual capital has a significant negative effect on the board of directors and board of commissioners, while the board of directors and board of commissioners have a significant positive effect on financial performance. Practical implications: Intellectual capital affects financial performance through the board of directors and board of commissioners’ as the mediating variables supported by the category of competitive mediation (inconsistent mediation). This competitive mediation provides support for the mediating effect hypothesis. Paper type: Research paper
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Kim, Hanjoe. "Mediation Analysis With a Survival Mediator." Multivariate Behavioral Research 52, no. 1 (December 27, 2016): 105–6. http://dx.doi.org/10.1080/00273171.2016.1263549.

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De Girolamo, Debbie. "(2012) 30 Windsor Y B Access Just 103 A VIEW FROM WITHIN: RECONCEPTUALIZING MEDIATOR INTERACTIONS." Windsor Yearbook of Access to Justice 30, no. 2 (October 1, 2012): 103. http://dx.doi.org/10.22329/wyaj.v30i2.4371.

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This paper explores mediator interactions from within the mediation process. It is difficult to obtain access to mediations due to issues of confidentiality and litigation privilege, thus restricting direct empirical research. During a yearlong ethnographic study during which the author was a participant-observer of a number of commercial mediations, the nature of mediations was explored from an independent observational perspective – separate from the process yet within the process. In this study, real life patterns of interactions are examined through case study analysis. It offers a reconceptualization of the nature of mediator interventions, one that moves beyond the accepted understanding of third party intervention. It suggests that the mediator has a fugitive identity in mediation, reflecting a traditional neutral third party intervener role, a party role and an adviser role.Dans le présent document, l‟auteure explore les interactions des médiateurs dans le cadre du processus de médiation. Il est difficile d‟obtenir l‟accès aux séances de médiation en raison du secret professionnel et du privilège relatif au litige, et cette difficulté limite la recherche empirique directe. Au cours d‟une étude ethnographique qui s‟est déroulée sur une année et à laquelle l‟auteure a participé comme observatrice d‟un certain nombre de médiations commerciales, la nature des médiations a été explorée d‟un point de vue observationnel indépendant – distinct du processus bien qu‟au sein du processus. Dans la présente étude, des situations réelles d‟interaction sont examinées au moyen de l‟analyse d‟études de cas. L‟auteure offre une reconceptualisation de la nature des interventions du médiateur, qui va au-delà de ce qui est reconnu comme l‟intervention d‟une tierce partie. Le médiateur aurait une identité fugace dans le processus de médiation, cette identité s‟expliquant par un rôle traditionnel de tiers intervenant neutre, un rôle de partie et un rôle de conseiller.
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Zhang, Yafei, and Li Chen. "Exploration of factors leading to successful mediation." International Journal of Conflict Management 28, no. 1 (February 13, 2017): 24–49. http://dx.doi.org/10.1108/ijcma-12-2015-0087.

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Purpose The purpose of this study is to explore possible factors leading to a successful mediation in Chinese mediation shows. In China, media always play an indispensable role in information dissemination, morality advocacy and policy explanation. Design/methodology/approach This paper employed content analysis of 166 episodes of one representative mediation show, Gold Medal Mediation, and regression technique in data analysis. Findings Results of ordinal regression suggested that “secret talking”, rather than transparency, between disputants had significant influence on successful mediation. Function of mediators is limited in reaching full mediation. The effective factors leading to full mediation include compromise of rights, secret talking, attitude of the observer cohort. It suggests that the role of mediator is limited, rather than being over-exaggerated, in successful mediation. The successful mediation is largely dependent on disputants’ motivations. Additionally, “compromise of rights” by disputants is a key factor in solving disputes. Research limitations/implications Findings of this study revealed the role of Chinese mediation shows in propagating mediation in contemporary Chinese society and supporting upheld morality values. Due to the nature of the chosen mediation show, some disputes take more than one episode to solve. However, this study looks at each episode without considering the integrity of the dispute. That is, if the disputes take two episodes, the coder codes the two episodes as two separate disputes instead of looking at it as one dispute. Originality/value By exploring various aspects of mediations shows, including the role of mediators, disputants and a cohort of observers, this study can both explicitly show predicted factors to successful mediations on the shows, and can implicitly examine the power and perceived justification of mediation in contemporary China via media.
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Shao, Zhonghe, Ting Wang, Meng Zhang, Zhou Jiang, Shuiping Huang, and Ping Zeng. "IUSMMT: Survival mediation analysis of gene expression with multiple DNA methylation exposures and its application to cancers of TCGA." PLOS Computational Biology 17, no. 8 (August 31, 2021): e1009250. http://dx.doi.org/10.1371/journal.pcbi.1009250.

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Effective and powerful survival mediation models are currently lacking. To partly fill such knowledge gap, we particularly focus on the mediation analysis that includes multiple DNA methylations acting as exposures, one gene expression as the mediator and one survival time as the outcome. We proposed IUSMMT (intersection-union survival mixture-adjusted mediation test) to effectively examine the existence of mediation effect by fitting an empirical three-component mixture null distribution. With extensive simulation studies, we demonstrated the advantage of IUSMMT over existing methods. We applied IUSMMT to ten TCGA cancers and identified multiple genes that exhibited mediating effects. We further revealed that most of the identified regions, in which genes behaved as active mediators, were cancer type-specific and exhibited a full mediation from DNA methylation CpG sites to the survival risk of various types of cancers. Overall, IUSMMT represents an effective and powerful alternative for survival mediation analysis; our results also provide new insights into the functional role of DNA methylation and gene expression in cancer progression/prognosis and demonstrate potential therapeutic targets for future clinical practice.
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Albert, Jeffrey M., Cuiyu Geng, and Suchitra Nelson. "Causal mediation analysis with a latent mediator." Biometrical Journal 58, no. 3 (September 13, 2015): 535–48. http://dx.doi.org/10.1002/bimj.201400124.

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Solimun, Solimun, and Adji Achmad Rinaldo Fernandes. "Investigation the mediating variable: What is necessary? (case study in management research)." International Journal of Law and Management 59, no. 6 (November 13, 2017): 1059–67. http://dx.doi.org/10.1108/ijlma-09-2016-0077.

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Purpose This study aims to more deeply examine the various types of testing mediations and use the comparison test by using test-based mediation Sobel models and Bayesian approach. The purpose of this study are to apply the traditional (using indirect effect) and Sobel test, extend Yuan and MacKinnon (2009) work on Bayesian mediation analysis. Both analysis methods of mediation (Traditional, Sobel Test and Bayesian estimation) should apply in the research of management, by using structural equation modeling (SEM) in a structural model, with one mediation, one exogenous (independent) and one endogenous variable. The meta-analysis approximation has been used to investigate the job satisfaction as a mediation in the relationship between employee competence and performance (endogenous). Design/methodology/approach Data were collected from ten dissertations of students of the Management Doctoral Program at the Brawijaya University from 2009 until 2013; data were analyzed for the mediation variable of job satisfaction (M) in the relationship between employee competence (X) and employee performance (Y) (Muindi and Obonyo, 2015; Olcer, 2015; Sattar et al., 2015; Khan and Ahmed, 2015). A researcher can determine the mediating variable and whether it is complete or partial or if mediation exists in several ways. Findings The results of the above findings using meta-analysis showed that 60% of previous research states that job satisfaction is a partial mediation on relationship competence of the performance, 10% of previous research states that job satisfaction is a full mediation on relationship competence of the performance and 30% stated that job satisfaction is not pemediasi (pemediasi means Mediation variable) on the relationship between competence and performance. This research found that all three approaches provide similar conclusions for ten previous research. Research limitations/implications The findings showed that the Sobel approach and the Bayesian approach provide results that are more sensitive than the traditional approach. Practical implications In my opinion, the rule to investigate the mediation variable should be completed with the conditions (1) q (theta) is not statistically significant, (2) α (alpha) and β (beta) are significant, and (3) q’ (theta) is significant, and increase when M is include as an additional predictor. This condition called partial mediation. Social implications The traditional method is simpler and easy. The method is less sensitive and is not sufficient for investigating the mediating variables. In general, the method results in a mediation variable, but it cannot be used to determine either partial or complete mediation variables. So, investigation by Baron and Kenny Methods (in Hair et al., 2010), the rule or testing called Sobel Test and another approach such as Bayesian to determine the mediation variable is necessary. Originality/value Various methods for detecting mediating/intervening have been widely used in previous research as a method of measurement using indirect effect (Hair et al., 2010), and calculations have been performed using Sobel test (Baron and Kenny, 1986) and Bayesian approach (Enders, 2013). In this study, I wanted to more deeply examine the various types of testing mediations, and use the comparison test by using the test-based mediation Sobel models and Bayesian approach (Baron and Kenny, 1986; Enders, 2013). The statistical application should not be complicated and difficult, it but must rather be simple and easy, so that it is user-friendly. The traditional method is simpler and easier than the other methods, but how sensitive is it? This research is conducted to investigate this problem. The evaluation of mediating mechanisms has become a critical element of behavioral science research (Enders, 2013), especially in the field of management, not only to assess whether (and how) interventions achieve their effects but also, more, broadly, to understand the cause of behavioral change. Methodologists have developed mediation analysis techniques for a broad range of substantive applications. However, methods for estimating mediation mechanisms with various methods have been understudied. The purpose of this study is to apply the traditional (using indirect effect) and Sobel tests and extend Yuan and MacKinnon’s (2009) work on the Bayesian mediation analysis. Both analyses methods of mediation (traditional and Sobel test and Bayesian estimation) should apply in the research of management, by using structural equation modeling (SEM) in a structural model, with one mediation, one exogenous (independent) and one endogenous variable. The meta-analysis approximation has been used to investigate job satisfaction as the mediation in the relationship between employee competence and performance (endogenous). This study uses software R to complete the mediating effect (Enders, 2013). R is a language and environment for statistical computing and graphics. It is a GNU project which is similar to the S language and environment which was developed at Bell Laboratories (formerly AT&T, now Lucent Technologies) by John Chambers et al. R provides a wide variety of statistical analyses such as SEM and Mediation test. R provides an open source route for participation in that activity. The Bayesian estimation approach provides an R function and a macro that applies the method of mediation analysis.
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Dissertations / Theses on the topic "Mediation analysi"

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Janson, Emma. "Mediating with God : Quantitative Analysis on Mediation and Religiosity - What effect does severity of conflict have on mediation onset in religious conflicts?" Thesis, Uppsala universitet, Institutionen för freds- och konfliktforskning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373136.

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The number of conflicts with religious dimensions has been steadily increasing over the last few decades. Previous research has found that religious conflicts are less likely to end by mediation whilst little research has been done as to what makes them initiate mediation. Building upon Ripeness Theory, this paper argues that the religious component makes religious parties less sensitive towards mutually hurting stalemates, but not immune to them, due to their heterogenous nature. This proposition is analysed by examining the empirical pattern of mediation onset in conflicts over religious incompatibilities using a logistic regression analysis. The findings suggest that higher numbers of average battle-related deaths, together with the duration of conflict and presence of crude oil reserves, increase the likelihood of mediation onset, whilst differentiations in centrality of a religious goal or religious identity divides have no statistically significant effect.
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Wang, Wei. "CAUSAL MEDIATION ANALYSIS FOR NON-LINEAR MODELS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332961697.

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Hill, Chris. "A pragmatic analysis of family mediation." Thesis, Bangor University, 2007. https://research.bangor.ac.uk/portal/en/theses/a-pragmatic-analysis-of-family-mediation(c7c254b4-b9f8-4c94-8f98-9a2f5e0fd9e5).html.

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Family (or divorce) mediation aims to assist couples who are separating or divorcing to come to agreed arrangements regarding children, property and finances. In the UK it is a service which is offered as an alternative to litigation and is not, at this stage, compulsory. Family mediation is an interactional setting which combines elements of both formality and informality: in theory mediators control the process of the encounter, whilst clients control the outcome. Mediators are also charged with conducting themselves in a manner which is neutral as to outcome, and impartial as to process. In reality, of course, the language behaviours of both practitioners and clients are not so clearly delineated. This research is based upon audio recordings of mediation sessions in the North Wales Service and takes an interactional pragmatic approach. The primary analytic `tools' are the concepts of complex illocutionary acts and discourse roles as developed by Thomas (1995,2004,2006 and forthcoming). A number of topics are considered, in particular the verbal enactment of mediator impartiality and neutrality, and of power and politeness by both clients and practitioners.
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Valeri, Linda. "Statistical Methods for Causal Mediation Analysis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10690.

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Mediation analysis is a popular approach in the social an biomedical sciences to examine the extent to which the effect of an exposure on an outcome is through an intermediate variable (mediator) and the extent to which the effect is direct. We first develop statistical methods and software for the estimation of direct and indirect causal effects in generalized linear models when exposure-mediator interaction may be present. We then study the bias of direct and indirect effects estimators that arise in this context when a continuous mediator is measured with error or a binary mediator is misclassified. We develop methods of correction for measurement error and misclassification coupled with sensitivity analyses for which no auxiliary information on the mediator measured with error is needed. The proposed methods are applied to a lung cancer study to evaluate the effect of genetic variants mediated through smoking on lung cancer risk and to a perinatal epidemiological study on the determinants of preterm birth.
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Sy, Oumar Sekou. "Multilevel mediation analysis estimation and applications /." Search for this dissertation online, 2004. http://wwwlib.umi.com/cr/ksu/main.

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Deng, Yiheng. "Neutrality and Power Distribution in Chinese Mediation: Discourse Analysis on Some Contemporary Chinese Mediation Strategies Based on Real Mediation Sessions." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195644.

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The study aims to discover the strategies and techniques used by community mediators in the People's Republic of China. Previous research argues that mediator legitimacy in China draws on state authorization and the mediator's community standing. In contrast to Western conceptions of the mediator's role as a neutral facilitator of dispute resolution, research suggests that Chinese mediators openly speak on behalf of community norms, calling on disputants to subordinate personal preferences in the interest of maintaining harmonious relationships and governmental policies and legal regulations. The legitimacy of the mediation process depends more on a persuasive articulation of community norms than an impression of mediator neutrality. However, this account of Chinese mediation has been based solely on interview and questionnaire data. How (and whether) this contrast between self-report measures and mediation techniques in practice actually manifests itself in mediator discourse, at what stages, and to what degree has not really been observed or analyzed. This study records and analyzes community mediation cases to better understand what features are prevalent in mediation discourse. Cases were selected in both rural and urban areas. Discourse analysis is applied to transcripts so as to provide direct and detailed picture of how mediation is conducted in reality. Strategies typical of Chinese mediation, relative to American mediation are identified and illustrated with excerpts from the transcripts. Neutrality and power distribution are discussed and compared with their roles in American mediation. Their implications for political, social and cultural aspects are drawn to provide a glimpse of contemporary Chinese society and how resolution is created. Future research directions are pointed out with regard to mediator's gender difference, the location where the mediation happens (urban and rural) and the socio-economic class of disputants (e.g., migrant workers) involved in the mediation.
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Gao, Tianming. "Bayesian Causal Mediation Analysis with Multiple Mediators." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1512649229134385.

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Rockwood, Nicholas John. "Advancing the Formulation and Testing of Multilevel Mediation and Moderated Mediation Models." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1489578419777238.

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Baspaly, Dave. "Analysis of community mediation programs in North America." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ54546.pdf.

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Zheng, Ning. "Mediation modeling and analysis forhigh-throughput omics data." Thesis, Uppsala universitet, Statistiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256318.

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There is a strong need for powerful unified statistical methods for discovering underlying genetic architecture of complex traits with the assistance of omics information. In this paper, two methods aiming to detect novel association between the human genome and complex traits using intermediate omics data are developed based on statistical mediation modeling. We demonstrate theoretically that given proper mediators, the proposed statistical mediation models have better power than genome-wide association studies (GWAS) to detect associations missed in standard GWAS that ignore the mediators. For each ofthe modeling methods in this paper, an empirical example is given, where the association between a SNP and BMI missed by standard GWAS can be discovered by mediation analysis.
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Books on the topic "Mediation analysi"

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Iacobucci, Dawn. Mediation analysis. Los Angeles: Sage, 2008.

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Iacobucci, Dawn. Mediation analysis. Los Angeles: Sage, 2008.

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Iacobucci, Dawn. Mediation Analysis. 2455 Teller Road, Thousand Oaks California 91320 United States of America: SAGE Publications, Inc., 2008. http://dx.doi.org/10.4135/9781412984966.

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M, Maxwell Madeline, ed. Storied conflict talk: Narrative construction in mediation. Amsterdam: John Benjamins Pub. Co., 2010.

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Stewart, Katherine A. Storied conflict talk: Narrative construction in mediation. Amsterdam: John Benjamins Pub. Co., 2010.

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Jabri, Vivienne. Discourses on violence: Conflict analysis reconsidered. Manchester: Manchester University Press, 1996.

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1954-, Monk Gerald, ed. Practicing narrative mediation: Loosening the grip of conflict. San Francisco: Jossey-Bass, 2008.

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Spindler, Gerald. Gerichtsnahe Mediation in Niedersachsen: Eine juristisch- rechtsökonomische Analyse. Göttingen: Universitätsverlag Göttingen, 2006.

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John, Winslade, ed. When stories clash: Addressing conflict with narrative mediation. Chagrin Falls, Ohio: Taos Institute Publications, 2013.

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Shailor, Jonathan G. Empowerment in dispute mediation: A critical analysis of communication. Westport, Conn: Praeger, 1994.

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Book chapters on the topic "Mediation analysi"

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Hair, Joseph F., G. Tomas M. Hult, Christian M. Ringle, Marko Sarstedt, Nicholas P. Danks, and Soumya Ray. "Mediation Analysis." In Classroom Companion: Business, 139–53. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80519-7_7.

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AbstractMediation occurs when a third variable, referred to as a mediator construct, intervenes between two other directly related constructs. More precisely, a change in the exogenous construct results in a change of the mediator construct, which in turn changes the endogenous construct. The mediator analysis evaluates the factors related to the cause–effect relationship between an exogenous construct and an endogenous construct. In the simplest form, the analysis considers only one mediator construct, but the path model can also include multiple mediating constructs simultaneously, as well as moderated mediation. We illustrate mediation analysis in PLS-SEM by using the SEMinR package and the corporate reputation model as an example.
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Huber, Martin. "Mediation Analysis." In Handbook of Labor, Human Resources and Population Economics, 1–38. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-57365-6_162-1.

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Huber, Martin. "Mediation Analysis." In Handbook of Labor, Human Resources and Population Economics, 1–38. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-57365-6_162-2.

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Tofighi, Davood. "Mediation Analysis." In Encyclopedia of Quality of Life and Well-Being Research, 3963–66. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-0753-5_1771.

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Steen, Johan, and Stijn Vansteelandt. "Mediation Analysis." In Handbook of Graphical Models, 405–38. Boca Raton, Florida : CRC Press, c2019.: CRC Press, 2018. http://dx.doi.org/10.1201/9780429463976-17.

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MacKinnon, David P., JeeWon Cheong, and Angela G. Pirlott. "Statistical mediation analysis." In APA handbook of research methods in psychology, Vol 2: Research designs: Quantitative, qualitative, neuropsychological, and biological., 313–31. Washington: American Psychological Association, 2012. http://dx.doi.org/10.1037/13620-018.

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Dugard, Pat, John Todman, and Harry Staines. "Partial correlation, mediation and moderation." In Approaching Multivariate Analysis, 139–58. 2nd ed. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003343097-6.

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Kals, Elisabeth, Jürgen Maes, and Heidi Ittner. "Basiswissen Mediation: Konflikte deeskalieren – Die psychologische Analyse eines Fallbeispiels." In Praxishandbuch Professionelle Mediation, 1–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49657-2_28-1.

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Tallodi, Timea. "Interpretations Across Cases: The Overarching Analysis." In How Parties Experience Mediation, 227–70. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-28239-4_10.

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Gatignon, Hubert. "Testing Mediation and Moderation Effects." In Statistical Analysis of Management Data, 349–452. Boston, MA: Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-8594-0_11.

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Conference papers on the topic "Mediation analysi"

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Portere, Viktorija, and Baiba Briede. "The Meaning of Constructivist Approach in Mediation and the Role of the Mediator." In 14th International Scientific Conference "Rural Environment. Education. Personality. (REEP)". Latvia University of Life Sciences and Technologies. Faculty of Engineering. Institute of Education and Home Economics, 2021. http://dx.doi.org/10.22616/reep.2021.14.032.

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The process of overcoming a conflict in mediation using constructivist ideas is revealed in the study. A mediator’s roles in the frame of the constructivist approach represent the topicality of the study. The mediator’s role is analysed and the emphasis is on the constructivist frame. The mediator’s pedagogical role is in the centre of the study. In the process of the study, the aim was to find out theoretical explanations of the meaning of the constructivist approach in mediation, how it occurs and what is the role of mediator in the mediation process based on dialogue? The methodology of the study comprises a theoretical assessment of the role of the mediator based on a constructivist approach with a purposeful emphasis on a dialogue between parties. The mediator facilitates a dialogical mediation process being also a pedagogue who helps the parties to learn how to keep a dialogue. Analysis of the mediator’s role and the usage of D.A. Kolb’s learning types in the stages of mediation are the main results of the study. The significance of the study implies a substantiation of various roles of the mediator, constructivist approach with the emphasis on the dialogue and implementation of D.A. Kolb’s learning types in the stages of mediation.
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Tang, Karen, Elijah Otis, Alexandra Loverock, Cameron Wild, and Igor Yakovenko. "The Role of Motives in Understanding the Link Between Personality and Cannabis Misuse." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.19.

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Background and aim: A robust association exists between substance use and personality, with personality risk factors representing phenotypes of vulnerability to substance misuse. As such, personality risk factors may be valuable constructs for understanding specific motivations for substance misuse. Given the loosening of restrictions on cannabis worldwide, research focusing on understanding cannabis use in young adults, a particularly at-risk population, remains a vital area of research. The existing data provides extensive support for the mediating role of coping motives on personality risk factors and problematic cannabis use; however, the role of other types of motives has remained largely unexplored. Our study examined the mediating role of cannabis use motives between personality and cannabis misuse among university students. We also explored the predictive value of personality phenotypes for cannabis use problems. Research question and hypothesis: Do motivations for cannabis use mediate or explain the relationship between personality type and cannabis use problem severity? Hypothesis 1: sensation-seeking (SS) and impulsivity (IMP), but not anxiety sensitivity and hopelessness, will be associated with greater cannabis use problem severity. Hypothesis 2: motives for use (i.e., coping, conformity, social, enhancement, expansion) will mediate the association between personality risk and cannabis use problem severity. Method: A survey was administered to 1073 undergraduate students. We examined whether motivations for use (mediator variable) explained the relationship between personality (predictor variable) and cannabis use disorder severity (outcome variable) using an ordinary least-squares (OLS) based mediation analysis. Results: As hypothesized, SS and IMP predicted greater cannabis use problems. A noteworthy finding was that conformity motives were a significant mediator between SS and IMP and cannabis use, whereby higher levels of SS/IMP led to greater endorsement of conformity motives, which in turn led to lower cannabis misuse. Enhancement motives were also a significant mediator between IMP and cannabis use. Expansion motives were a significant mediator between SS and cannabis use. Conclusion: Understanding reasons for use (i.e., motives) allows us to identify those at greatest risk for cannabis misuse. Findings from this study may help explain the underlying mechanisms by which personality risk factors lead to cannabis use disorder in young adults. A greater understanding of these personality phenotypes may have implications for the development of personality-specific interventions for cannabis use.
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Portere, Viktorija, and Vladimirs Morevs. "Dialogue is a sign of constructiveness in mediation." In Research for Rural Development 2020. Latvia University of Life Sciences and Technologies, 2020. http://dx.doi.org/10.22616/rrd.26.2020.043.

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Dialogue (discourse) is the main indication leading us to the conclusion that mediation is constructive. Discourse, the main form of dialogue, allows to achieve a positive result of mediation – an agreement between the participants of the conflict, as well as to learn dialogue communication skills. The aim of this study is to determine the types of dialogue used in mediation, the usage of recognized dialogue, and to find methods for assessing the dialogue (discourse) skills that need to be taught to the participants of the conflict, as well as future mediators and to evaluate the effectiveness of mediation. The research was conducted based on the theoretical methods of analysis of modern concept of dialogue and empirical testing methods (using questionnaires) of the participants of the conflicts and future mediators. Methods of mathematical statistics were used, when processing and analyzing the results of the questionnaires. As a result of this work, the types of dialogue used in mediation are identified, recommendations on the choice of components and barriers of dialogue to be considered by the mediator when training participants in the conflict and future mediators are made, as well as recommendations on assessment the effectiveness of mediation are offered.
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Bal, Harun, Mehmet Demiral, and Emrah Eray Akça. "Mediating Effect of the Governance Indicators in the Relationship between Natural Resources Abundance and Economic Growth: Empirical Evidence from the." In International Conference on Eurasian Economies. Eurasian Economists Association, 2014. http://dx.doi.org/10.36880/c05.00950.

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This study purposes to identify the relationship between gross domestic product (GDP) and natural resources abundance, focusing on the mediator roles of governance indicators for selected 21 MENA and Caspian countries. Governance indicators used in the study are World Bank’s six global governance indicators. Annual panel data for the period of 1996-2012 are used. In this context, the study estimates the impact of crude oil production per capita (independent variable) on GDP per capita (dependent variable) at first, and then hierarchical panel regression analyses are conducted to determine the mediator variable roles of the governance indicators in this relationship. Sobel test is also applied to confirm whether the mediation effect is significant. Results from the pairwise panel regression analyses reveal that crude oil production per capita is negatively associated with all worldwide governance indicators, mostly with control of corruption, voice and accountability and regulatory quality. The progressive improvements of all dimensions of governance indicators, especially control of corruption, rule of law and government effectiveness, seem to promote GDP per capita. Results from the hierarchical regression analysis demonstrate that governance indicators play an important role as a partial mediator in the relationships crude oil production and GDP per capita. This evidence supports that weak governance indicators tend to hinder natural resources abundance to contribute economic growth. Overall findings highlight the increasing importance of policies intending to reduce corruption and violence, together with stimulating legitimacy, transparency and institutional quality for the countries investigated.
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Zinovieva, Darina. "MEDIATION AND MEDIATORS IN THE HEALTHCARE." In THE MEDIATION IN THE DIFFERENT PUBLIC SPHERES 2021. University publishing house "Science and Economics", University of Economics - Varna, 2021. http://dx.doi.org/10.36997/mdps2021.24.

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It is considered how mediation is regulated as an out-of-court way of agreement between two disputing parties in the healthcare system. For this purpose, an analysis of the current general and special laws, according to which such an agreement can be implemented, has been made. Practical issues related to problems in the implementation of the agreement are also presented, in view of the specifics of the disputes in the healthcare sector. The new legal figure of a "health mediator" is analyzed, the rights and obligations that are normatively regulated, the benefits and the needs for optimization of the regulation. The results of the analysis are summarized and specific conclusions "de lege ferenda" are proposed.
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Zinovieva, Darina. "MEDIATION AND MEDIATORS IN THE HEALTHCARE." In THE MEDIATION IN THE DIFFERENT PUBLIC SPHERES 2021. University publishing house "Science and Economics", University of Economics - Varna, 2021. http://dx.doi.org/10.36997/mdps2021.2.

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It is considered how mediation is regulated as an out-of-court way of agreement between two disputing parties in the healthcare system. For this purpose, an analysis of the current general and special laws, according to which such an agreement can be implemented, has been made. Practical issues related to problems in the implementation of the agreement are also presented, in view of the specifics of the disputes in the healthcare sector. The new legal figure of a "health mediator" is analyzed, the rights and obligations that are normatively regulated, the benefits and the needs for optimization of the regulation. The results of the analysis are summarized and specific conclusions "de lege ferenda" are proposed.
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Wang, Zenan, Xuan Yin, Tianbo Li, and Liangjie Hong. "Causal Meta-Mediation Analysis." In KDD '20: The 26th ACM SIGKDD Conference on Knowledge Discovery and Data Mining. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3394486.3403313.

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Wang, weixin. "Economic Analysis of Mediation." In 2020 3rd International Conference on Humanities Education and Social Sciences (ICHESS 2020). Paris, France: Atlantis Press, 2020. http://dx.doi.org/10.2991/assehr.k.201214.551.

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Ferrante, Lucrezia, Claudia Venuleo, and Simone Rollo. "PROBLEMATIC INTERNET USE AMONG ADOLESCENTS AND THE VIEW OF CONTEXT: A PLS-STRUCTURAL EQUATION MODEL." In International Psychological Applications Conference and Trends. inScience Press, 2021. http://dx.doi.org/10.36315/2021inpact020.

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"The idea of Internet use as a way to face psychosocial malaise is growing in the scientific literature about Problematic Internet Use (PIU). The present study, assuming the Semiotic Cultural Psycho-social Theory (SCPT) (Salvatore, 2018) as theoretical framework, postulates and emphasizes that the context in which the subject is embedded provide the symbolic resources, which ground the way adolescents perceive, experience, and therefore deal with the material and social world, including the likelihood of using the Internet as a way to facing life problems and difficulties. SCTP adopts the term “Symbolic Universes” (SU) to denote affect-laden assumptions concerning the world which may (or not) promote adaptive responses. Specifically, the present study aimed to test a mediation model in which each Symbolic Universes (i.e. independent variable) is associated with the psychosocial malaise in terms of social anxiety, loneliness, and negative emotions (i.e. mediator variable), which in turn has effects on PIU (i.e. dependent variable). Measures of PIU (GPIUS), symbolic universes (VOC), negative affect (PANAS), social anxiety (IAS), loneliness (ILs) among a total of 764 Southern Italy youths aged from 13 to 19 (mean age =15.05 ± 1.152). A Multiple Correspondence Analysis (MCA) was firstly run to detect SU; a Partial Least Squares Structural Equation Modelling (PLS-SEM) was then performed on R for testing the hypothesized mediation model. The results demonstrated that Symbolic Universes characterized by anomie and unreliability of the social context are associated with adolescents’ PIU though the mediation of social anxiety, loneliness, and negative emotions. Overall, findings suggest that within an anomic and unreliable scenario, PIU might acquire the meaning of a way to face life in an environment that seems meaningless, uncertain, and detrimental. On the plane of intervention, this points to the need for programs that address social and cultural influences in youths’ Internet use."
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Liu, Wei, Jing Wang, and Deng Chen. "GCC based agents collaboration mediation." In ICGDA '18: 2018 the International Conference on Geoinformatics and Data Analysis, ICGDA '18. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3220228.3220250.

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Reports on the topic "Mediation analysi"

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Heckert, Jessica, Jessica Leight, Josué Awonon, and Aulo Gelli. Understanding the role of different program components of a nutrition sensitive intervention in mediating impact: Applying causal mediation analysis to experimental evidence from Burkina Faso. Washington, DC: International Food Policy Research Institute, 2021. http://dx.doi.org/10.2499/p15738coll2.134866.

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Al Saleh, Abdullah. Conflict Analysis: Exploring the Role of Kuwait in Mediation in the Middle East. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.3199.

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Frölich, Markus, and Martin Huber. Direct and indirect treatment effects: causal chains and mediation analysis with instrumental variables. Cemmap, July 2014. http://dx.doi.org/10.1920/wp.cem.2014.3114.

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Bijlsma, Maarten J., and Ben Wilson. Modelling the socio-economic determinants of fertility: a mediation analysis using the parametric g-formula. Rostock: Max Planck Institute for Demographic Research, May 2017. http://dx.doi.org/10.4054/mpidr-wp-2017-013.

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Heckman, James, and Rodrigo Pinto. Econometric Mediation Analyses: Identifying the Sources of Treatment Effects from Experimentally Estimated Production Technologies with Unmeasured and Mismeasured Inputs. Cambridge, MA: National Bureau of Economic Research, August 2013. http://dx.doi.org/10.3386/w19314.

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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, June 2013. http://dx.doi.org/10.32747/2013.7699847.bard.

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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL target genes and bioinformatic analysis of data to eulcidate gene-network topology. Objective-3 (Israel-TAU): Regulation of GTLmediated transcription by Ca²⁺/calmodulin: mechanism and biological significance. Objective-4 (Israel-BGU): Metabolic networks and carbon partitioning in response to drought. Additional direction: In the course of the project we added another direction, which was reported in the 2nd annual report, to elucidate genes controlling drought avoidance. The TAU team has isolated a few unhydrotropic (hyd) mutants and are in the process of mapping these mutations (of hyd13 and hyd15; see last year's report for a description of these mutants under salt stress) in the Arabidopsis genome by map-based cloning and deep sequencing. For this purpose, each hyd mutant was crossed with a wild type plant of the Landsberg ecotype, and at the F2 stage, 500-700 seedlings showing the unhydrotropic phenotype were collected separately and pooled DNA samples were subkected to the Illumina deep sequencing technology. Bioinformatics were used to identify the exact genomic positions of the mutations (based on a comparison of the genomic sequences of the two Arabidopsis thaliana ecotypes (Columbia and Landsberg). Background: To feed the 9 billion people or more, expected to live on Earth by the mid 21st century, the production of high-quality food must increase substantially. Based on a 2009 Declaration of the World Summit on Food Security, a target of 70% more global food production by the year 2050 was marked, an unprecedented food-production growth rate. Importantly, due to the larger areas of low-yielding land globally, low-yielding environments offer the greatest opportunity for substantial increases in global food production. Nowadays, 70% of the global available water is used by agriculture, and 40% of the world food is produced from irrigated soils. Therefore, much needs to be done towards improving the efficiency of water use by plants, accompanied by increased crop yield production under water-limiting conditions. Major conclusions, solutions and achievements: We established that AtGTL1 (Arabidopsis thaliana GT-2 LIKE1) is a focal determinant in water deficit (drought) signaling and tolerance, and water use efficiency (WUE). The GTL1 transcription factor is an upstream regulator of stomatal development as a transrepressor of AtSDD1, which encodes a subtilisin protease that activates a MAP kinase pathway that negatively regulates stomatal lineage and density. GTL1 binds to the core GT3 cis-element in the SDD1 promoter and transrepresses its expression under water-sufficient conditions. GTL1 loss-of-function mutants have reduced stomatal number and transpiration, and enhanced drought tolerance and WUE. In this case, higher WUE under water sufficient conditions occurs without reduction in absolute biomass accumulation or carbon assimilation, indicating that gtl1-mediated effects on stomatal conductance and transpiration do not substantially affect CO₂ uptake. These results are proof-of-concept that fine-tuned regulation of stomatal density can result in drought tolerance and higher WUE with maintenance of yield stability. Implications: Accomplishments during the IS-4243-09R project provide unique tools for continued discovery research to enhance plant drought tolerance and WUE.
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Philosoph-Hadas, Sonia, Peter Kaufman, Shimon Meir, and Abraham Halevy. Signal Transduction Pathway of Hormonal Action in Control and Regulation of the Gravitropic Response of Cut Flowering Stems during Storage and Transport. United States Department of Agriculture, October 1999. http://dx.doi.org/10.32747/1999.7695838.bard.

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Original objectives: The basic goal of the present project was to increase our understanding of the cellular mechanisms operating during the gravitropic response of cut flowers, for solving their bending problem without affecting flower quality. Thus, several elements operating at the 3 levels o the gravity-induced signal transduction pathway, were proposed to be examined in snapdragon stems according to the following research goals: 1) Signaling: characterize the signal transduction pathway leading to the gravitropic response, regarding the involvement of [Ca2+]cyt as a mediator of IAA movement and sensitivity to auxin. 2) Transduction by plant hormones: a) Examine the involvement of auxin in the gravitropic response of flower stems with regard to: possible participation of auxin binding protein (ABP), auxin redistribution, auxin mechanism of action (activation of H+-ATPase) mediation by changes in [Ca2+]cyt and possible regulation of auxin-induced Ca2+ action b: calmodulin-activated or Ca2+-activated protein kinases (PK). b) Examine the involvement of ethylene in the gravitropic response of flower stems with regard to auxin-induced ethylene production and sensitivity of the tissue to ethylene. 3) Response: examine the effect of gravistimulation on invertase (associated with growth and elongation) activity and invertase gene expression. 4) Commercial practice: develop practical and simple treatments to prevent bending of cut flowers grown for export. Revisions: 1) Model systems: in addition to snapdragon (Antirrhinum majus L.), 3 other model shoe systems, consisting of oat (Avena sativa) pulvini, Ornithogalun 'Nova' cut flowers and Arabidopsis thaliana inflorescence, were targeted to confirm a more general mechanism for shoot gravitropism. 2 Research topics: the involvement of ABP, auxin action, PK and invertase in the gravitropic response of snapdragon stems could not be demonstrated. Alternatively, the involvement in the gravity signaling cascade of several other physiological mediators apart of [Ca2+]cyt such as: IP3, protein phosphorylation and actin cytoskeleton, was shown. Additional topics introduced: starch statolith reorientation, differential expression of early auxin responsive genes, and differential shoot growth. Background to the topic: The gravitropic bending response of flowering shoots occurring upon their horizontal placement during shipment exhibits a major horticultural problem. In spite of extensive studies in various aboveground organs, the gravitropic response was hardly investigated in flowering shoots. Being a complex multistep process that requires the participation of various cellular components acting in succession or in parallel, analysis of the negative gravitropic response of shoot includes investigation of signal transduction elements and various regulatory physiological mediators. Major achievements: 1) A correlative role for starch statoliths as gravireceptors in flowering shoot was initially established. 2) Differentially phosphorylated proteins and IP3 levels across the oat shoe pulvini, as well as a differential appearance of 2 early auxin-responsive genes in snapdragon stems were all detected within 5-30 minutes following gravistimulation. 3) Unlike in roots, involvement of actin cytoskeleton in early events of the gravitropic response of snapdragon shoots was established. 4) An asymmetric IAA distribution, followed by an asymmetric ethylene production across snapdragon stems was found following gravistimulation. 5) The gravity-induced differential growth in shoots of snapdragon was derived from initial shrinkage of the upper stem side and a subsequent elongation o the lower stem side. 6) Shoot bending could be successfully inhibited by Ca2+ antagonists (that serve as a basis for practical treatments), kinase and phosphatase inhibitors and actin-cytoskeleton modulators. All these agents did not affect vertical growth. The essential characterization of these key events and their sequence led us to the conclusion that blocking gravity perception may be the most powerful means to inhibit bending without hampering shoot and flower growth after harvest. Implications, scientific and agriculture: The innovative results of this project have provided some new insight in the basic understanding of gravitropism in flower stalks, that partially filled the gap in our knowledge, and established useful means for its control. Additionally, our analysis has advanced the understanding of important and fundamental physiological processes involved, thereby leading to new ideas for agriculture. Gravitropism has an important impact on agriculture, particularly for controlling the bending of various important agricultural products with economic value. So far, no safe control of the undesired bending problem of flower stalks has been established. Our results show for the first time that shoot bending of cut flowers can be inhibited without adverse effects by controlling the gravity perception step with Ca2+ antagonists and cytoskeleton modulators. Such a practical benefit resulting from this project is of great economic value for the floriculture industry.
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Barash, Itamar, J. Mina Bissell, Alexander Faerman, and Moshe Shani. Modification of Milk Composition via Transgenesis: The Role of the Extracellular Matrix in Regulating Transgene Expression. United States Department of Agriculture, July 1995. http://dx.doi.org/10.32747/1995.7570558.bard.

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Altering milk composition via transgenesis depends on three main factors. (1) The availability of an efficient regulatory sequences for targeting transgene(s) to the mammary gland; (2) a reliable in vitro model to test the expression of transgenes prior to their introduction to the animal genome; and (3) better understanding of the major factors which determine the rate of gene expression and protein synthesis. The current studies provide the necessary means and knowledge to alter milk protein composition via transgenesis. The following specific goals were achieved: a: Identifying regulatory regions in the b-lactoglobulin (BLG) gene and the cross-talk between elements which enabled us to construct an efficient vector for the expression of desirable cDNA's in the mammary gland. b: The establishment of a sheep mammary cell line that serves as a model for the analysis of endogenous and exogenous milk protein synthesis in the mammary gland of livestock. c: An accurate comparison of the potency of the 5' regulatory sequences from the BLG and whey acidic protein (WAP) promoters in directing the expression of human serum albumin (HSA) to the mammary gland in vitro and in vivo. In this study we have also shown that sequences within the coding region may determine a specific pattern of expression for the transgene, distinct from that of the native milk protein genes. d: Characterizing the dominant role of ECM in transgene expression in mammary epithelial cells. e: Further characterization of the BCE-1 enhancer element in the promoter of the b-casein gene as a binding site for the c/EBP-b and Stat5. Identifying its interaction with chromatin and its up regulation by inhibitors of histone deacetylation. f: Identifying a mechanism of translational control as a mediator for the synergistic effect of insulin and prolactin on protein synthesis in the mammary gland.
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Philosoph-Hadas, Sonia, Peter B. Kaufman, Shimon Meir, and Abraham H. Halevy. Inhibition of the Gravitropic Shoot Bending in Stored Cut Flowers Through Control of Their Graviperception: Involvement of the Cytoskeleton and Cytosolic Calcium. United States Department of Agriculture, December 2005. http://dx.doi.org/10.32747/2005.7586533.bard.

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Original objectives: The basic goal of the present project was to study the mechanism involved in shoot graviperception and early transduction, in order to determine the sequence of events operating in this process. This will enable to control the entire process of gravity-induced differential growth without affecting vertical growth processes essential for development. Thus, several new postulated interactions, operating at the perception and early transduction stages of the signaling cascade leading to auxin-mediated bending, were proposed to be examined in snapdragon spikes and oat shoot pulvini, according to the following research goals: 1) Establish the role of amyloplasts as gravireceptors in shoots; 2) Investigate gravity-induced changes in the integrity of shoot actin cytoskeleton (CK); 3) Study the cellular interactions among actin CK, statoliths and cell membranes (endoplasmic reticulum - ER, plasma membrane - PM) during shoot graviperception; 4) Examine mediation of graviperception by modulations of cytosolic calcium - [Ca2+]cyt, and other second messengers (protein phosphorylation, inositol 1,4,5-trisphosphate - IP3). Revisions: 1) Model system: in addition to snapdragon (Antirrhinum majus L.) spikes and oat (Avena sativa) shoot pulvini, the model system of maize (Zea mays) primary roots was targeted to confirm a more general mechanism for graviperception. 2) Research topic: brassinolide, which were not included in the original plan, were examined for their regulatory role in gravity perception and signal transduction in roots, in relation to auxin and ethylene. Background to the topic: The negative gravitropic response of shoots is a complex multi-step process that requires the participation of various cellular components acting in succession or in parallel. Most of the long-lasting studies regarding the link between graviperception and cellular components were focused mainly on roots, and there are relatively few reports on shoot graviperception. Our previous project has successfully characterized several key events occurring during shoot bending of cut flowers and oat pulvini, including amyloplast displacement, hormonal interactions and differential growth analysis. Based on this evidence, the present project has focused on studying the initial graviperception process in flowering stems and cereal shoots. Major conclusions and achievements: 1) The actin and not the microtubule (MT) CK is involved in the graviperception of snapdragon shoots. 2) Gravisensing, exhibited by amyloplast displacement, and early transduction events (auxin redistribution) in the gravitropic response of snapdragon spikes are mediated by the acto-myosin complex. 3) MTs are involved in stem directional growth, which occurs during gravitropism of cut snapdragon spikes, but they are not necessary for the gravity-induced differential growth. 4) The role of amyloplasts as gravisensors in the shoot endodermis was demonstrated for both plant systems. 5) A gravity-induced increase in IP.
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. face of interaction of anti-insect selective toxins with receptor site-3 on voltage-gated sodium channels as a platform for design of novel selective insecticides. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7699857.bard.

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Voltage-gated sodium channels (Navs) play a pivotal role in excitability and are a prime target of insecticides like pyrethroids. Yet, these insecticides are non-specific due to conservation of Navs in animals, raising risks to the environment and humans. Moreover, insecticide overuse leads to resistance buildup among insect pests, which increases misuse and risks. This sad reality demands novel, more selective, insect killers whose alternative use would avoid or reduce this pressure. As highly selective insect toxins exist in venomous animals, why not exploit this gift of nature and harness them in insect pest control? Many of these peptide toxins target Navs, and since their direct use via transformed crop plants or mediator microorganisms is problematic in public opinion, we focus on the elucidation of their receptor binding sites with the incentive of raising knowledge for design of toxin peptide mimetics. This approach is preferred nowadays by agro-industries in terms of future production expenses and public concern. However, characterization of a non-continuous epitope, that is the channel receptor binding site for such toxins, requires a suitable experimental system. We have established such a system within more than a decade and reached the stage where we employ a number of different insect-selective toxins for the identification of their receptor sites on Navs. Among these toxins we wish to focus on those that bind at receptor site-3 and inhibit Nav inactivation because: (1) We established efficient experimental systems for production and manipulation of site-3 toxins from scorpions and sea anemones. These peptides vary in size and structure but compete for site-3 on insect Navs. Moreover, these toxins exhibit synergism with pyrethroids and with other channel ligands; (2) We determined their bioactive surfaces towards insect and mammalian receptors (see list of publications); (3) We found that despite the similar mode of action on channel inactivation, the preference of the toxins for insect and mammalian channel subtypes varies greatly, which can direct us to structural features in the basis of selectivity; (4) We have identified by channel loop swapping and point mutagenesis extracellular segments of the Navinvolved with receptor site-3. On this basis and using channel scanning mutagenesis, neurotoxin binding, electrophysiological analyses, and structural data we offer: (i) To identify the residues that form receptor site-3 at insect and mammalian Navs; (ii) To identify by comparative analysis differences at site-3 that dictate selectivity toward various Navs; (iii) To exploit the known toxin structures and bioactive surfaces for modeling their docking at the insect and mammalian channel receptors. The results of this study will enable rational design of novel anti-insect peptide mimetics with minimized risks to human health and to the environment. We anticipate that the release of receptor site-3 molecular details would initiate a worldwide effort to design peptide mimetics for that site. This will establish new strategies in insect pest control using alternative insecticides and the combined use of compounds that interact allosterically leading to increased efficiency and reduced risks to humans or resistance buildup among insect pests.
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