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Journal articles on the topic 'Mediator’s action'

Author: Grafiati

Published: 23 September 2022

Last updated: 31 July 2025

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1

Korybski, Andrzej. "Status prawny mediatora w postępowaniu mediacyjnym w sprawach cywilnych." Studia Iuridica Lublinensia 27, no. 3 (2018): 143. http://dx.doi.org/10.17951/sil.2018.27.3.143-162.

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<p>In statutory legal cultures, both the introduction of mediation into the legal order and the determination of the legal status of the mediator and his responsibility require legislative action. This is the situation of the Polish legal order. Mediation proceedings in civil cases were introduced into the Polish civil procedure in 2005, while in 2015 the mediation model in civil cases was substantially significantly amended. The mediator’s status has also changed as a result of the introduction of a new type of mediator – the so-called permanent mediator, and with a slightly different s

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Liang, Jing, and Xornam Apedoe. "Teacher as a Mediator in Foreign Language Speaking Fluency Development: A Case Study of an Advanced-Placement Chinese TBLT Classroom." Journal of Language Teaching and Research 16, no. 3 (2025): 703–14. https://doi.org/10.17507/jltr.1603.01.

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This action research case study will help educators conceptualize the mediator’s role by investigating how mediation is used under the guidance of Reuven Feuerstein’s Mediated Learning Experience theory to aid learners’ fluency development in an Advanced-Placement Chinese high-school Task-Based Language Teaching classroom in America. Findings from this mixed-methods action research study first suggest what types of mediation might influence fluency development after finding mediation of intentionality and mediation of feeling of competence were practiced most and much more frequently than othe

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Lu, Meiyu. "LEARNER AGENCY, ENGLISH PROFICIENCY, AND LEARNING BEYOND THE CLASSROOM: LESSONS FROM TEN ADVANCED EFL LEARNERS." LLT Journal: A Journal on Language and Language Teaching 27, no. 2 (2024): 780–802. http://dx.doi.org/10.24071/llt.v27i2.8996.

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Within the framework of sociocultural theories, this study investigated how affordances in various beyond the classroom settings supported the development of agency and English proficiency among advanced EFL learners. The participants were 10 Taiwanese college students, each with at least B2 proficiency according to the Common European Framework of Reference for Languages. Data were gathered through a qualitative approach encompassing semi-structured interviews, writing samples, and a 23-item questionnaire. A grounded theory approach was adopted to analyze and interpret the data. The findings

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Tan, Woan Sean, Palanisamy Arulselvan, Govindarajan Karthivashan та Sharida Fakurazi. "Moringa oleiferaFlower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway". Mediators of Inflammation 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/720171.

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Aim of Study.Moringa oleiferaLam. (M. oleifera) possess highest concentration of antioxidant bioactive compounds and is anticipated to be used as an alternative medicine for inflammation. In the present study, we investigated the anti-inflammatory activity of 80% hydroethanolic extract ofM. oleiferaflower on proinflammatory mediators and cytokines produced in lipopolysaccharide- (LPS-) induced RAW 264.7 macrophages.Materials and Methods. Cell cytotoxicity was conducted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Nitric oxide (NO) production was quantified throu

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Tabernacka, Magdalena. "Mediatorzy i instytucje mediacyjne w otoczeniu administracji." Przegląd Prawa i Administracji 111 (February 28, 2018): 183–96. http://dx.doi.org/10.19195/0137-1134.111.12.

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MEDIATORS AND MEDIATION BODIES SURROUNDED BY THE ENVIRONMENT ADMINISTRATIONSince 1 June 2017, mediations in administration have astatutory foundation in the provisions of the code of administrative proceedings. Mediator’s actions, which, according to Art. 96 of the code are to help parties to adispute to settle it amicably affect the administrative bodies’ jurisprudence. It can thus be expected that, as was the case with criminal and civil legal proceedings, mediators will become an indispensable part of the administrative office environment, and that mediation itself will influence the orga

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Heinrichs, Arianne. "Mediator action." Nature Structural & Molecular Biology 18, no. 11 (2011): 1183. http://dx.doi.org/10.1038/nsmb.2184.

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Galanos, C., and M. A. Freudenberg. "Bacterial endotoxins: biological properties and mechanisms of action." Mediators of Inflammation 2, no. 7 (1993): S11—S16. http://dx.doi.org/10.1155/s0962935193000687.

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Endotoxins (lipopolysaccharides, LPS) are agents of pathogenicity of Gram-negative bacteria, implicated in the development of Gram-negative shock. Endotoxin reacts with lipopolysaccharide-sensitive cells producing endogenous mediators such as tumour necrosis factor alpha (TNFα). Macrophages are cells mediating the toxic activities of LPS and TNFα is the primary mediator of the lethal action of endotoxin. This review article discusses the various mechanisms by which endotoxin hypersensitivity in bacteria-sensitized animals develops. The paper concludes with a discussion on the possible protecti

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MEZHENIN, Y. E., and A. M. SHEVYAKOVA. "CONSTRUCTIVE COMMUNICATIONS IN THE MANAGEMENT OF INTERPERSONAL CONFLICTS IN THE MEDIATION PROCEDURE." Central Russian Journal of Social Sciences 16, no. 1 (2021): 44–56. http://dx.doi.org/10.22394/2071-2367-2021-16-1-44-56.

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The purpose of the article is to consider the structure of mediation session and standardization of the mediation procedure in the management of interpersonal conflicts. The research methodology is based on the theory of conflict, which understands sociology, the narrative approach, as well as the fundamental scientific developments of sociology and psychology of conflict. In various approaches to the mediation procedure, caucus is regarded as a key stage, since it is it that has the greatest influence on the result of the entire negotiation procedure with the participation of a mediator. The

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Brooker, Penny. "Mediator immunity: time for evaluation in England and Wales?" Legal Studies 36, no. 3 (2016): 464–90. http://dx.doi.org/10.1111/lest.12120.

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In England and Wales, the issue of mediator immunity has not been considered by the courts or via legislation. Mediator immunity is constructed by analogy to that given to judges, but the role of the judiciary is different to that of mediators, who do not determine cases and, it is argued, do not require protection from litigation because the parties are responsible for the final settlement outcome. In Australia and the USA, mediators are usually provided with immunity in mandatory, ‘court-annexed’ programmes, although this varies from an absolute to a qualified level that is constrained by ba

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10

Cheng, K., and J. Larner. "Intracellular Mediators of Insulin Action." Annual Review of Physiology 47, no. 1 (1985): 405–24. http://dx.doi.org/10.1146/annurev.ph.47.030185.002201.

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11

Gottschalk, W. Kirby, and Leonard Jarett. "Intracellular mediators of insulin action." Diabetes / Metabolism Reviews 1, no. 3 (1985): 229–59. http://dx.doi.org/10.1002/dmr.5610010302.

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12

Ramon, Sesquile, Charles Serhan, and Richard Phipps. "Actions of novel inflammation-resolving lipid mediators on human B cells (84.9)." Journal of Immunology 184, no. 1_Supplement (2010): 84.9. http://dx.doi.org/10.4049/jimmunol.184.supp.84.9.

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Abstract The resolution of inflammation is an active and dynamic process. Newly identified lipid mediators have been recognized as key players during the process of inflammation resolution. These lipid-derived molecules constitute three classes of compounds (lipoxins, resolvins and protectins), all derived from essential fatty acids. New data demonstrates that these lipid mediators regulate aspects of the immune response, including inhibition of neutrophil infiltration, reduction of T cell cytokine production and stimulation of macrophage phagocytic activity. However, their effects on B lympho

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Grima, François, and Georges Trépo. "Knowledge, action and public concern: the logic underlying mediators' actions in French labour conflicts." International Journal of Human Resource Management 20, no. 5 (2009): 1172–90. http://dx.doi.org/10.1080/09585190902850349.

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14

Gorman, Rachel da Silveira, and Iffath Unissa Syed. "Expanding the scope of mast cell disease: Does mast cell‐derived TNF play a role in immune‐mediated chronic illness and autoimmunity?" Rheumatology & Autoimmunity 4, no. 4 (2024): 218–25. https://doi.org/10.1002/rai2.12151.

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AbstractIncreasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for mast cell activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions, conversely, tend to prioritize histamine, prostaglandins, and leukotrienes. This article, via a review of both experimental and clinical findings, spotlights the mechanisms of action of an important mast cell mediator – tumor necrosis factor (TNF), and elucidates the intricate linkages between mast cell dysfunction, chronic illness, a

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Yamamuro, Shintaro, Tomohiro Shinozaki, Satoshi Iimuro, and Yutaka Matsuyama. "Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory actions in elderly type 2 diabetics." Statistical Methods in Medical Research 30, no. 8 (2021): 1782–99. http://dx.doi.org/10.1177/09622802211025988.

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Modern causal mediation theory has formalized several types of indirect and direct effects of treatment on outcomes regarding specific mediator variables. We reviewed and unified distinct approaches to estimate the “interventional” direct and indirect effects for multiple mediators and time-varying variables. This study was motivated by a clinical trial of elderly type-2 diabetic patients in which atorvastatin was widely prescribed to control patients’ cholesterol levels to reduce diabetic complications, including cardiovascular disease. Among atorvastatin’s preventive side-effects (pleiotropi

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Furuyashiki, Tomoyuki, Satoshi Akiyama, and Shiho Kitaoka. "Roles of multiple lipid mediators in stress and depression." International Immunology 31, no. 9 (2019): 579–87. http://dx.doi.org/10.1093/intimm/dxz023.

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AbstractProlonged or excessive stress may induce emotional and cognitive disturbances, and is a risk factor for mental illnesses. Using rodent chronic stress models of depression, roles of multiple lipid mediators related to inflammation have been revealed in chronic stress-induced emotional alterations. Prostaglandin (PG) E2, an arachidonic acid (AA)-derived lipid mediator, and its receptor subtype EP1 mediate depression-like behavior induced by repeated social defeat stress through attenuating prefrontal dopaminergic activity. Repeated social defeat stress activates microglia through innate

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Kaufman, Ruth. "The Process of Experiencing Mediated Learning as a Result of Peer Collaboration Between Young Adults With Severe Learning Difficulties." Journal of Cognitive Education and Psychology 5, no. 2 (2005): 215–16. http://dx.doi.org/10.1891/194589505787382540.

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Mediated learning is an interpersonal experience in which the mediator’s role is to develop in the mediatee functions essential for learning. The mediator focuses on the mediatee while identifying, analyzing, formulating, and solving problems related to everyday life and formal education frameworks. This study was focused upon the mediators, their experience in mediated learning, and the development of mediational abilities and cognitive functions as a result of social goals.Mediation was carried out in pairs and in a group format. The group was composed of low-functioning young adults sufferi

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18

Farese, R. V. "Lipid-Derived Mediators in Insulin Action." Experimental Biology and Medicine 195, no. 3 (1990): 312–24. http://dx.doi.org/10.3181/00379727-195-43150c.

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GOTTSCHALK, W. K., S. L. MACAULAY, J. O. MACAULAY, K. KELLY, J. A. SMITH, and L. JARETT. "Characterization of Mediators of Insulin Action." Annals of the New York Academy of Sciences 488, no. 1 Membrane Path (1986): 385–405. http://dx.doi.org/10.1111/j.1749-6632.1986.tb46573.x.

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Flower, R. J. "Inflammation: The mediators of steroid action." Nature 320, no. 6057 (1986): 20. http://dx.doi.org/10.1038/320020a0.

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21

Patapoutian, Ardem, and Louis F. Reichardt. "Trk receptors: mediators of neurotrophin action." Current Opinion in Neurobiology 11, no. 3 (2001): 272–80. http://dx.doi.org/10.1016/s0959-4388(00)00208-7.

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22

Schrör, Karsten, and Thomas Hohlfeld. "Antiinflammatory effects of aspirin in ACS: relevant to its cardio coronary actions?" Thrombosis and Haemostasis 114, no. 09 (2015): 469–77. http://dx.doi.org/10.1160/th15-03-0191.

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SummaryVascular injury in acute coronary syndromes (ACS) involves a complex cross-talk between inflammatory mediators, platelets and thrombosis, where the interaction between platelets and coagulation factors (e. g. thrombin) is a central link between thrombosis and inflammation. In ACS, aspirin at antiplatelet doses exhibits anti-inflammatory effects as seen from the decrease in inflammation markers such as CRP, M-CSF, MCP-1 and others. These actions probably occur subsequent to inhibition of platelet COX-1-dependent thromboxane formation and its action as a multipotent autocrine and paracrin

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Baraldi, Claudio, and Laura Gavioli. "On professional and non-professional interpreting in healthcare services: the case of intercultural mediators." European Journal of Applied Linguistics 4, no. 1 (2016): 33–55. http://dx.doi.org/10.1515/eujal-2015-0026.

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AbstractA debate that has revolved around the organisation of Italian healthcare interpreting services concerns the choice adopted by most institutions to employ intercultural mediators rather than professional interpreters. Intercultural mediators do not necessarily have a professional training in interpreting, they are, however, preferred to professional interpreters in that they are considered more competent in mediating the possibly different perspectives of healthcare providers and migrant patients. This preference provides food for thought for reflections on professionalism in interprete

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Zhang, Xingyan. "Loratadine and sodium cromoglycate Two drugs under type 1 hypersensitivity reaction in response to hay fever." Applied and Computational Engineering 85, no. 1 (2024): 61–71. http://dx.doi.org/10.54254/2755-2721/85/20240671.

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This paper aims to explain the mechanism of Type 1 hypersensitivity and the corresponding action of loratadine and sodium cromoglycate. Type 1 hypersensitivity is the most common type of allergy, which is caused by mast cells and leukocytes releasing chemical mediators, including histamines, cytokines, etc. Chemical mediators cause inflammatory responses, as well as bind to receptors that generate symptoms of allergies. Coping with the reaction, loratadine is a type of antihistamine that can inhibit the activation of the H1 receptor by histamines, it is a drug that performs inverse agonism. Wh

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Neuhof, Heinz. "Actions and interactions of mediator systems and mediators in the pathogenesis of ARDS and multiorgan failure." Acta Anaesthesiologica Scandinavica 35 (September 1991): 7–14. http://dx.doi.org/10.1111/j.1399-6576.1991.tb03394.x.

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Touzet, Sandrine, Karine Buchet-Poyau, Angelique Denis, et al. "P-224 IMPACT OF THE PRESENCE OF A MEDIATOR IN EMERGENCY DEPARTMENTS ON PATIENT VIOLENT BEHAVIOURS AGAINST HEALTHCARE WORKERS." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0796.

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Abstract Introduction Considering violent behaviors from patients towards healthcare workers (HCW) in emergency departments (EDs), we evaluated the impact of mediators in EDs on violent behaviors perpetrated by patients or their relatives against HCW and on HCW well-being at work. Methods A randomized trial was performed in 4 French EDs during 12 months. EDs’HCW, patients aged ≥18 and their relatives were included. Four mediators worked alternately in the EDs. The main outcome was the rate of ED visits with at least one act of violence carried out by a patient or relatives declared by HCW. HCW

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Olszewski, Michal A., Xiang-Yang Zhang, and N. Edward Robinson. "Pre- and postjunctional effects of inflammatory mediators in horse airways." American Journal of Physiology-Lung Cellular and Molecular Physiology 277, no. 2 (1999): L327—L333. http://dx.doi.org/10.1152/ajplung.1999.277.2.l327.

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In addition to their direct contractile effects, histamine (Hist), serotonin [5-hydroxytryptamine (5-HT)], and leukotriene (LT) D4, in low concentrations, dramatically augment electrical field stimulation (EFS)-induced smooth muscle contractions in equine airways. To determine the mechanism of their action, we studied, in trachealis strips, the effect of these mediators on both cholinergically induced tension and the release of ACh from cholinergic nerves. All three mediators synergistically augmented the contraction of the trachealis that was due to release of endogenous ACh, i.e., EFS-induce

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Kim, Hee-Yong, Bill X. Huang, and Arthur A. Spector. "Molecular and Signaling Mechanisms for Docosahexaenoic Acid-Derived Neurodevelopment and Neuroprotection." International Journal of Molecular Sciences 23, no. 9 (2022): 4635. http://dx.doi.org/10.3390/ijms23094635.

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The neurodevelopmental and neuroprotective actions of docosahexaenoic acid (DHA) are mediated by mechanisms involving membrane- and metabolite-related signal transduction. A key characteristic in the membrane-mediated action of DHA results from the stimulated synthesis of neuronal phosphatidylserine (PS). The resulting DHA-PS-rich membrane domains facilitate the translocation and activation of kinases such as Raf-1, protein kinase C (PKC), and Akt. The activation of these signaling pathways promotes neuronal development and survival. DHA is also metabolized in neural tissues to bioactive media

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Markiewicz, Katarzyna. "MEDIATORS OF RELATIONSHIPS BETWEEN PROCRASTINATION AND NEUROTICISM." Acta Neuropsychologica 15, no. 3 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.6095.

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Background: Procrastination means delaying action, which creates serious problems both in academic, work, and clinical settings since it leads to reduced performance levels, and gives rise to psychological distress resulting in lower levels of health and well-being. Therefore, it is imperative to acquire a better know ledge of its reasons and relationships with psychological factors. Yet, the nature of those rela tionships remains am biguous. One of reasons is that many fac tors considered as causes of procrastination work as mediators, modify ing the relationships of procrastination with othe

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Boyle, Christina N., Yi Zheng, and Thomas A. Lutz. "Mediators of Amylin Action in Metabolic Control." Journal of Clinical Medicine 11, no. 8 (2022): 2207. http://dx.doi.org/10.3390/jcm11082207.

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Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli. The last 35 years of intensive research have shown that amylin exerts important physiological effects on metabolic control. Most importantly, amylin is a physiological control of meal-ending satiation, and it limits the rate of gastric emptying and reduces the secretion of pancreatic glucagon, in particular in postprandial states. The physiological effects of amylin and its analogs are mediated by direct brain activation, with the caudal hind

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NOY, Noa. "Retinoid-binding proteins: mediators of retinoid action." Biochemical Journal 348, no. 3 (2000): 481. http://dx.doi.org/10.1042/0264-6021:3480481.

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NOY, Noa. "Retinoid-binding proteins: mediators of retinoid action." Biochemical Journal 348, no. 3 (2000): 481–95. http://dx.doi.org/10.1042/bj3480481.

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Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids with high selectivity and affinity. Traditionally, retinoid-binding proteins were viewed as transport proteins that act by solubilizing and protecting their labile ligands in aqueous spaces. It is becoming increasingly clear, however, that, in addit

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Wihlborg, Elin, and Kristina Söderholm. "Mediators in action: Organizing sociotechnical system change." Technology in Society 35, no. 4 (2013): 267–75. http://dx.doi.org/10.1016/j.techsoc.2013.09.004.

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Fishman, Jerry H., and Jack Fishman. "Copper and endogenous mediators of estradiol action." Biochemical and Biophysical Research Communications 152, no. 2 (1988): 783–88. http://dx.doi.org/10.1016/s0006-291x(88)80106-2.

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Robertson, Scott A., Gina M. Leinninger, and Martin G. Myers. "Molecular and neural mediators of leptin action." Physiology & Behavior 94, no. 5 (2008): 637–42. http://dx.doi.org/10.1016/j.physbeh.2008.04.005.

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Wallace, John L., Gerald P. Morris, Paul L. Beck, Todd E. Williamson, and Guy R. Gingras. "Effects of sucralfate on gastric prostaglandin and leukotriene synthesis: relationship to protective actions." Canadian Journal of Physiology and Pharmacology 66, no. 5 (1988): 666–70. http://dx.doi.org/10.1139/y88-105.

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The mechanism of the protective actions of sucralfate against ethanol-induced gastric mucosal damage in the rat has been investigated. In particular, the role of prostaglandins as mediators of such protection was assessed. Oral administration of sucralfate at a dose causing a significant reduction of ethanol-induced gastric damage (500 mg/kg) did not significantly alter gastric 6-ketoprostaglandin F1α synthesis. Pretreatment with indomethacin at a dose that inhibited gastric cyclooxygenase activity by an average of 88% did not affect the protective actions of sucralfate. To further investigate

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Potthast, A., T. Rosenau, H. Koch, and K. Fischer. "The Reaction of Phenolic Model Compounds in the Laccase-Mediator System (LMS) Investigations by Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS)." Holzforschung 53, no. 2 (1999): 175–80. http://dx.doi.org/10.1515/hf.1999.029.

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SummaryMatrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was used to investigate the reaction products obtained by treatment of phenolic substances with the laccase-mediator system, consisting of the enzyme laccase and a low-molecular-weight substance, the so-called mediator.Two mediators, 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid diammonium salt (ABTS) and 1-hydroxybenzotriazole (HOBT), were employed. Polymerizing and depolymerizing properties of the LMS were investigated and assigned to specific components of the system,i. e., laccase an

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Karčić, Hamza. "Camp David and Dayton: Comparing Jimmy Carter and Richard Holbrooke as Mediators." International Negotiation 22, no. 1 (2017): 1–32. http://dx.doi.org/10.1163/15718069-12341354.

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u.s. mediation towards resolving the Arab-Israeli conflict in the 1970s and Balkan conflicts in the 1990s may not seem comparable at first. Differences between these conflicts in terms of history, duration and dynamics abound. The nature and level of u.s. involvement provides further contrasts. Yet, the Camp David negotiations in 1978 and the Dayton Peace Talks in 1995 offer striking parallels in terms of third-party mediator actions undertaken. This article compares the two summits by applying the analytic framework developed by Curran, Sebenius and Watkins to categorize third party mediator

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Pedrosa, Gabriel Frazao Silva. "The Educational Development of Autistic Students." International Journal of Innovative Science and Research Technology 5, no. 4 (2020): 327–29. http://dx.doi.org/10.38124/ijisrt20apr498.

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The demand for an egalitarian education is a recurring subject in the current educational scenario, especially with regard to the inclusion of students with special educational needs, also, the need for a mediator to promote the development of the student in its full educational process. The objective of this study is to describe the educational process of a student with autism spectrum disorder from the insertion of a mediator in this medium. This is a descriptive study with a qualitative approach, a type of experience report. Regarding the pedagogical activities proposed in the classroom, it

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Ana, Maria Costa e. Silva, and Guiomar Patrícia. "Mediators in Portugal: Training, Status and Professional Recognition." Journal of Social and Political Sciences 6, no. 1 (2023): 32–44. https://doi.org/10.31014/aior.1991.06.01.391.

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Mediation is an area of activity that has been increasingly (re)known for its potential for the prevention and positive management of conflicts, for the promotion of social ties and social cohesion, as well as for the development and empowerment of interpersonal relationships. Therefore, it seems relevant to call into discussion the quality of mediators' practices by analysing their training and professional recognition. The objectives of the present study have focused on identifying the main contexts associated with the development of the profile of mediators and analyzing the actions imp

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Calder, Philip C. "n-3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions." Proceedings of the Nutrition Society 72, no. 3 (2013): 326–36. http://dx.doi.org/10.1017/s0029665113001031.

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Numerous effects of n-3 fatty acids EPA and DHA on functional responses of cells involved in inflammation and immunity have been described. Fatty acid-induced modifications in membrane order and in the availability of substrates for eicosanoid synthesis are long-standing mechanisms that are considered important in explaining the effects observed. More recently, effects on signal transduction pathways and on gene expression profiles have been identified. Over the last 10 years or so, significant advances in understanding the mechanisms of action of n-3 fatty acids have been made. These include

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Nugraha, Iwan Saka, Ni Made Suastini, and Made Dwike Swari Santi. "ROLE OF PROBIOTICS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH HYPERTENSION: A REVIEW." Journal of Pharmaceutical Science and Application 5, no. 2 (2023): 70. http://dx.doi.org/10.24843/jpsa.2023.v05.i02.p03.

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Background: Type 2 Diabetes Mellitus (DM) is one of a global health problem. One of the comorbidities that often occurs in patients with type 2 DM is hypertension. Hypertension can increase the risk of cardiovascular complications. One of the causes of type 2 DM and hypertension is gut dysbiosis. An imbalance of gastrointestinal microbiota contributes to chronic inflammation and effects on the insulin action, increases insulin resistance, and leads to endothelial dysfunction. The role of this inflammatory mediator is a new therapeutic target in type 2 DM patients with hypertension. Objective:

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S, Sudjoko, Fathor Rozi, Zumrotus Sholehah, and Wardatul Jannah. "True or False Strategy Learning: Mediators Increase Students' Active Role in Class." Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini 7, no. 5 (2023): 6041–51. http://dx.doi.org/10.31004/obsesi.v7i5.4091.

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This research aimed to determine the implementation and success of true or false learning strategies which mediate students' active role in learning. This research used a qualitative approach with the type of Classroom Action Research. The subjects of this research were class B students (18 students). Data collection techniques used observation, interviews and documentation for each cycle process. Validate research data by means of technical triangulation. The results showed that students' active role scores have increased in each cycle action. It can be seen that the score for the active role

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MISAWA, Miwa, Saizo YANAURA, Tomokazu HOSOKAWA, et al. "Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators." Folia Pharmacologica Japonica 91, no. 2 (1988): 97–103. http://dx.doi.org/10.1254/fpj.91.97.

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Giacomini, Kathleen M. "Renal transporters: Mediators of drug disposition and action." Drug Metabolism and Pharmacokinetics 33, no. 1 (2018): S6. http://dx.doi.org/10.1016/j.dmpk.2017.11.029.

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Loffing, Johannes, Vanessa Summa, Marija Zecevic, and François Verrey. "Mediators of aldosterone action in the renal tubule." Current Opinion in Nephrology and Hypertension 10, no. 5 (2001): 667–75. http://dx.doi.org/10.1097/00041552-200109000-00019.

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Peskar, BM. "Inflammatory Mediators in Inflammatory Bowel Disease." Canadian Journal of Gastroenterology 4, no. 7 (1990): 289–94. http://dx.doi.org/10.1155/1990/362497.

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Tissue responses to an inflammatory stimulus (such as vasodilation, plasma exudation invasion and activation of inflammatory cells) are elicited by locally synthesized chemical mediators. Inhibition of biosynthesis and/or antagonism of action of these mediators is an important target of drug therapy, particularly when the cause of the disease is unknown. Recent investigations have revealed that the mucosa of inflammatory bowel disease (IBD) patients synthesizes a number of inflammatory mediators in increased amounts. These include the potent chemoattractant leukotricne B4, which seems to be re

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Zhang, Yong, Donald Y. M. Leung, and Elena Goleva. "Vitamin D Enhances Glucocorticoid Action in Human Monocytes." Journal of Biological Chemistry 288, no. 20 (2013): 14544–53. http://dx.doi.org/10.1074/jbc.m112.427054.

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Vitamin D (VitD) is now recognized for its pleiotrophic roles in regulating immune function. VitD interaction with other steroid receptor superfamily receptors in peripheral blood mononuclear cells is poorly understood. In the current study, we demonstrate that VitD enhanced glucocorticoid (GC) responses in human peripheral blood mononuclear cells because it stimulated GC induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) and enhanced GC inhibition of LPS-induced IL-6. These VitD effects were abolished in purified CD14+ and CD14− cells but were recovered in CD14+ cells co-cult

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Bianco, Piero R. "The Role of the RecFOR Complex in Genome Stability." International Journal of Molecular Sciences 26, no. 12 (2025): 5441. https://doi.org/10.3390/ijms26125441.

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The maintenance of genome stability requires the coordinated actions of multiple proteins and protein complexes. One critical family of proteins is the recombination mediators. Their role is to facilitate the formation of recombinase nucleoprotein filaments on single-stranded DNA (ssDNA). Filament formation can take place on post-replicative ssDNA gaps as well as on 3′-tailed duplexes resulting from helicase–nuclease processing. In prokaryotes, the RecF, O, and R proteins are widely distributed and mediate RecA loading as either the RecFOR or RecOR complexes, depending on the species being stu

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Gaginella, T. S., and J. F. Kachur. "Kinins as mediators of intestinal secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 256, no. 1 (1989): G1—G15. http://dx.doi.org/10.1152/ajpgi.1989.256.1.g1.

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Kinins are small peptides that have diverse biological actions. Concentrations of kinins in the nanomolar or subnanomolar range induce intestinal smooth muscle contraction and evoke mucosal electrolyte secretion. Hyperkininemia is associated with effects on gastrointestinal motility and intestinal mucosal inflammation. Bradykinin and kallidin are the predominant kinins with effects on the gastrointestinal tract of mammals. Bradykinin stimulates chloride ion secretion by the guinea pig and rabbit ileum, rabbit colon, rat colon and monolayers of human HCA-7 cells. Kinins directly or indirectly s

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