Academic literature on the topic 'Medical Biochemistry and Clinical Chemistry'

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Journal articles on the topic "Medical Biochemistry and Clinical Chemistry"

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Jovičić, Snežana, and Nada Majkić-Singh. "Medical Biochemistry as Subdiscipline of Laboratory Medicine in Serbia." Journal of Medical Biochemistry 36, no. 2 (April 1, 2017): 177–86. http://dx.doi.org/10.1515/jomb-2017-0010.

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SummaryMedical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and rules issued by the Chamber of Medical Biochemists of Serbia. The first continuous and organized education for Medical Biochemists (Clinical Chemists) in Serbia dates from 1945, when the Department of Medical Biochemistry was established at the Pharmaceutical Faculty in Belgrade. In 1987 at the same Faculty a five years undergraduate study program was established, educating Medical Biochemists under a special program. Since the academic year 2006/2007 the new five year undergraduate (according to Bologna Declaration) and four-year postgraduate program according to EC4 European Syllabus for Postgraduate Training in Clinical Chemistry and Laboratory Medicine has been established. The Ministry of Education and Ministry of Public Health accredited these programs. There are four requirements for practicing medical biochemistry in the Health Care System: University Diploma of the Faculty of Pharmacy (Study of Medical Biochemistry), successful completion of the professional exam at the Ministry of Health after completion of one additional year of obligatory practical training in the medical biochemistry laboratories, membership in the Serbian Chamber of Medical Biochemists and licence for skilled work issued by the Serbian Chamber of Medical Biochemists. In order to present laboratory medical biochemistry practice in Serbia this paper will be focused on the following: Serbian national legislation, healthcare services organization, sub-disciplines of laboratory medicine and medical biochemistry as the most significant, education in medical biochemistry, conditions for professional practice in medical biochemistry, continuous quality improvement, and accreditation. Serbian healthcare is based on fundamental principles of universal health coverage and solidarity between all citizens.
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Majkić-Singh, Nada. "Education and Recognition of Professional Qualifications in the Field of Medical Biochemistry in Serbia." Journal of Medical Biochemistry 30, no. 4 (October 1, 2011): 279–86. http://dx.doi.org/10.2478/v10011-011-0013-7.

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Education and Recognition of Professional Qualifications in the Field of Medical Biochemistry in Serbia Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and rules issued by the Chamber of Medical Biochemists of Serbia. The first continuous and organized education for Medical Biochemists (Clinical Chemists) in Serbia dates from 1945, when the Department of Medical Biochemistry was established at the Pharmaceutical Faculty in Belgrade. In 1987 at the same Faculty a five years undergraduate branch was established, educating Medical Biochemists under a special program. Since school-year 2006/2007 the new five year undergraduate (according to Bologna Declaration) and postgraduate program of four-year specialization according to EC4 European Syllabus for Post-Gradate Training in Clinical Chemistry and Laboratory Medicine has been established. The Ministry of Education and Ministry of Public Health accredits the programs. There are four requirements for practicing medical biochemistry in the Health Care System: University Diploma of the Faculty of Pharmacy (Study of Medical Biochemistry), successful completion of the profession exam at the Ministry of Health after completion of one additional year of obligatory practical training in the medical biochemistry laboratories, membership in the Serbian Chamber of Medical Biochemists and licence for skilled work issued by the Serbian Chamber of Medical Biochemists. The process of recognition of a foreign higher education document for field of medical biochemistry is initiated on request by Candidate. The process of recognition of foreign higher education documents is performed by the University. In the process of recognition in Serbia national legislations are applied as well as international legal documents of varying legal importance.
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Majkic-Singh, Nada. "Society of medical biochemists of Serbia and Montenegro: 50 years anniversary." Jugoslovenska medicinska biohemija 24, no. 3 (2005): 157–70. http://dx.doi.org/10.2298/jmh0503157m.

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Medical biochemistry (synonyms: clinical chemistry or clinical biochemistry) in the terms of professional and scientific discipline, stems from and/or has developed along with the natural sciences and its influences (mathematics, physics, chemistry and biochemistry) and medical sciences as well (physiology, genetics, cell biology). As a scientific discipline, medical biochemistry studies metabolic processes of physiological and pathological changes with humans and animals. Applying analytical chemistry's and biochemistry's techniques enables medical biochemists to gain plenty of information related to diagnosis and prognosis which serve physicians to asses the gravity of illness and prescribe healing therapy. Therefore medical biochemistry is an integral part of modern medicine. This discipline was dubbed various, often confusing names such as pathology, physiology, clinical biology, clinical pathology, chemical pathology, clinical biochemistry, medical biochemistry, clinical chemistry and laboratory medicine, all depending on place of origin. The official, internationally accepted name - clinical chemistry, was mentioned for the first time in 1912 by Johan Scherer, who described his laboratory as Clinical Chemistry Laboratory (Klinisch Chemische Laboratorium) in the hospital Julius in Wurzburg in Germany. After creating national societies of clinical chemists, Professor Earl J. King of Royal Postgraduate Medical School from London incited an initiative to unite national societies into the organization with worldwide character - it was the International Association of Clinical Biochemists, monitored by the International Union for Pure and Applied Chemistry (IUPAC). On 24 July 1952 in Paris, a Second International Congress of Biochemistry was held. A year later, in Stockholm, the name of a newly formed association was altered into International Federation of Clinical Chemistry, which was officially accepted in 1955 in Brussels. Today this federation-s name is International Federation for Clinical Chemistry and Laboratory Medicine (IFCC). Right after the World War II our medical biochemists began to gather within their expert societies. Even before 1950 Pharmaceutical Society of Serbia hosted laboratory experts among whom the most active were Prof. Dr. Aleksandar Damanski for bromatology, Prof. Dr. Momcilo Mokranjac for toxicology and Docent Dr. Pavle Trpinac for biochemistry. When the Managing Board of the Pharmaceutical Society of National Republic of Serbia held its session on 22 December 1950, an issue was raised with reference to creation of a Section that would gather together the laboratory experts. Section for Sanitary Chemistry, combining all three profiles of laboratory staff, i.e. medical biochemists, sanitary chemists and toxicologists, was founded on 1st of January 1951. On 15 May 1955, during the sixth plenum of the Society of Pharmaceutical Societies of Yugoslavia (SFRY) held in Split, the decision was passed to set up a Section for Medical Biochemistry in SFDJ. The Section for Medical Biochemistry in SFDJ was renamed into Society for Medical Biochemistry of SFDJ based on the decision passed during the 16th plenum of SFDJ, held on 15 May 1965 in Banja Luka. Pursuant to the decision passed by SMBY on 6 April 1995 and based on the historic data, 15 May was declared as being the official Day of the Society of Medical Biochemists of Yugoslavia. The purpose of YuSMB (currently SMBSCG) is to gather medical biochemists who would develop and enhance all the branches of medical biochemistry in health industry. Its tasks are as following: to standardize operations in clinical-biochemical laboratories, education of young biochemists on all levels, encouraging scientific research, setting up of working norms and implementation, execution and abiding by the ethics codices with health workers. SMBSCG is to promote the systemized standards in the field of medical biochemistry with the relevant federal and republican institutions. SMBSCG is to enable exchange of experiences of its members with the members of affiliate associations in the country and abroad. .
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Milosevic Georgiev, Andrijana, Dušanka Krajnović, Jelena Manojlović, Svetlana Ignatović, and Nada Majkić Singh. "Seventy Years of Biochemical Subjects’ Development in Pharmacy Curricula: Experience from Serbia/ Sedamdeset godina razvoja biohemijskih predmeta u kurikulumu farmacije: iskustvo iz srbije." Journal of Medical Biochemistry 35, no. 1 (January 1, 2016): 69–79. http://dx.doi.org/10.1515/jomb-2015-0018.

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Summary Introduction: The pharmacists played an important role in the development of biochemistry as applied chemistry in Serbia. What is more, the first seven state chemists in Ser bia were pharmacists. State chemists performed the chemicaltoxicological analysis as well as some medical and biochemical ones. When it comes to the education of medical biochemists as health workers, the period after the beginning of the second half of the twentieth century should be taken into account because that is when the training of pharmaceutical staff of the Faculty of Pharmacy, University of Belgrade, begins on the territory of Serbia. This paper presents the development of medical biochemistry through the development of curriculum, personnel and literature since the foundation of the Faculty of Pharmacy in Serbia until today. Objective: The aim of this paper is to present the historical development of biochemistry at the Faculty of Pharmacy, University of Belgrade, through analysis of three indicators: undergraduate and postgraduate education of medical biochemists, teaching literature and professional associations and trade associations. Method: The method of direct data was applied in this paper. Also, desktop analysis was used for analyzing of secondary data, regulations, curricula, documents and bibliographic material. Desktop research was conducted and based on the following sources: Archives of the University of Belgrade- Faculty of Pharmacy, Museum of the History of Pharmacy at the University of Belgrade-Faculty of Pharmacy, the Society of Medical Biochemists of Serbia and the Serbian Chamber of Biochemists. Results and conclusion: The curricula, the Bologna process of improving education, the expansion of the range of subjects, the number of students, professional literature for teaching biochemistry, as well as professional associations and trade associations are presented through the results.
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AHSAN, HASEEB. "Clinical Chemistry and Biochemistry: The Role of Biomarkers and Biomolecules." Asian Journal of Science Education 4, no. 1 (April 22, 2022): 17–24. http://dx.doi.org/10.24815/ajse.v4i1.24431.

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Biochemistry is a branch of biosciences which deals with the study of chemical reactions that occur in living cells and organisms. It is a subject in which biological phenomenon is analyzed in terms of chemical reactions or metabolic pathways. Biochemistry has been previously named as biological chemistry, chemical biology, clinical chemistry, chemical pathology, physiological chemistry, including medical biochemistry and clinical biochemistry. Medical biochemistry studies the chemical composition and physiological reactions in the human body. Clinical biochemistry is the measurement of chemicals or analytes in body fluids for the diagnosis, monitoring and management of patients with various diseases such as diabetes, cardiovascular diseases, etc. An increase in the number and availability of laboratory diagnostics has helped in the solution of clinical problems. Particularly important is the contribution of clinical chemistry to the diagnosis and monitoring of diabetes. The importance of lipids and lipoproteins for public health has increased with clinical studies showing the benefit of lipid lowering in cardiovascular diseases. An understanding of clinical chemistry and biochemistry would be useful in the study of medical and allied sciences for the advancement of knowledge in academic and professional courses. This review article is an attempt to understand the scope and significance of basic and applied aspects of biochemistry
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Rosenfeld, Louis. "Clinical Chemistry Since 1800: Growth and Development." Clinical Chemistry 48, no. 1 (January 1, 2002): 186–97. http://dx.doi.org/10.1093/clinchem/48.1.186.

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Abstract The 19th and 20th centuries witnessed the growth and development of clinical chemistry. Many of the individuals and the significance of their contributions are not very well known, especially to new members of the profession. This survey should help familiarize them with the names and significance of the contributions of physicians and chemists such as Fourcroy, Berzelius, Liebig, Prout, Bright, and Rees. Folin and Van Slyke are better known, and it was their work near the end of the second decade of the 20th century that brought the clinical chemist out of the annex of the mortuary and into close relationship with the patient at the bedside. However, the impact on clinical chemistry and the practice of medicine by the 1910 exposé written by Abraham Flexner is not as well known as it deserves to be, nor is the impetus that World War I gave to the spread of laboratory medicine generally known. In the closing decades of the 20th century, automated devices produced an overabundance, and an overuse and misuse, of testing to the detriment of careful history taking and bedside examination of the patient. This is attributable in part to a fascination with machine-produced data. There was also an increased awareness of the value of chemical methods of diagnosis and the need to bring clinician and clinical chemist into a closer partnership. Clinical chemists were urged to develop services into dynamic descriptions of the diagnostic values of laboratory results and to identify medical relevance in interpreting significance for the clinician.
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Hooper, J., J. O'Connor, R. Cheesmar, and C. P. Price. "Tutorial software for clinical chemistry incorporating interactive multimedia clinical cases." Clinical Chemistry 41, no. 9 (September 1, 1995): 1345–48. http://dx.doi.org/10.1093/clinchem/41.9.1345.

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Abstract We have developed computer-based clinical case histories incorporating multimedia elements to aid the learning of medicine in a problem-based manner. Topics have been developed in the specialty of Clinical Biochemistry but the approach used is suitable for any branch of clinical medicine. Each topic has material aimed at medical students and also postgraduate candidates for professional examinations. A browser program is also incorporated. Emphasis is made on interaction through the case and modeling of real-life decisions in diagnosis and treatment. Advantages of the program are self-paced learning, assessment of understanding, feedback, and emphasis on deep understanding of the basic physiological and biochemical processes underlying clinical problems.
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Williamson, R. "Molecular genetics and the transformation of clinical chemistry." Clinical Chemistry 35, no. 11 (November 1, 1989): 2165–68. http://dx.doi.org/10.1093/clinchem/35.11.2165.

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Abstract Clinical chemistry is going through an identity crisis, squeezed between automation (de-skilling) on the service side and molecular genetics in research. Automated routine estimations are now carried out and interpreted by machines; the skilled staff members required are more likely to have degrees in electronics than medicine or biochemistry. The role of molecular genetics is more ambiguous; it is inherently reductionist, in that it attempts to explain most clinical phenomena in terms of DNA sequence alone. This has been remarkably successful for single-gene defects (such as those causing Duchenne muscular dystrophy, hemoglobinopathies, cystic fibrosis, and ataxias) and may well prove equally so for Alzheimer's disease, cancer, heart disease, and schizophrenia. DNA diagnosis is not yet routine, but because of technical advances such as gene amplification ("PCR") and high-sensitivity gene-detection assays, it may soon become so, not only in major centers but also in local pathology laboratories and general practice. Clinical chemists must decide whether they wish to respond to this new and stimulating challenge by retooling and retraining. Should anyone be permitted into clinical chemistry during the 1990s without knowledge of both electronics and molecular genetics? Will there be a clinical chemistry in the twenty-first century other than through molecular genetics? This article is a personal response to these questions.
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Rej, Robert. "Clinical Chemistry through Clinical Chemistry: A Journal Timeline." Clinical Chemistry 50, no. 12 (December 1, 2004): 2415–58. http://dx.doi.org/10.1373/clinchem.2004.042820.

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Abstract The establishment of the modern discipline of clinical chemistry was concurrent with the foundation of the journal Clinical Chemistry and that of the American Association for Clinical Chemistry in the late 1940s and early 1950s. To mark the 50th volume of this Journal, I chronicle and highlight scientific milestones, and those within the discipline, as documented in the pages of Clinical Chemistry. Amazing progress has been made in the field of laboratory diagnostics over these five decades, in many cases paralleling—as well as being bolstered by—the rapid pace in the development of computer technologies. Specific areas of laboratory medicine particularly well represented in Clinical Chemistry include lipids, endocrinology, protein markers, quality of laboratory measurements, molecular diagnostics, and general advances in methodology and instrumentation.
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Peter Rae. "Clinical Chemistry." Clinica Chimica Acta 197, no. 2 (March 1991): 154–55. http://dx.doi.org/10.1016/0009-8981(91)90280-p.

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Dissertations / Theses on the topic "Medical Biochemistry and Clinical Chemistry"

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Stemp, Melissa. "Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/865.

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Molecular biomarkers are chemical signatures that all cell types possess. They are used in medicine to evaluate both normal biological events and pathogenic processes. A series of biomarkers associated with cancer of the breast, ovaries and other parts of the female reproductive tract and the monitoring of pregnancy were measured in disease‐free women. The biomarkers measured were prostate specific antigen (PSA), CA125, CA15‐3, CA72‐4, and pregnancy associated plasma protein‐a (PAPP‐A). The patterns of change during natural and stimulated ovarian cycles and early pregnancy were investigated to determine if these biomarkers could reflect normal events relating to ovulation and implantation/placentation. In addition, the study was able to investigate the possible erroneous crossing of clinical cut‐off values associated with disease due to other biological processes rather than the disease itself. total of 73 blood samples (10 women) taken throughout the natural menstrual cycle, 64 blood samples (11 women) during stimulated ovarian cycles and 86 blood samples (14 women) during early pregnancy monitoring were collected and all samples were analysed by batch analysis on the Roche Cobas e411. Concentrations of CA125, tPSA, CA15‐3 and CA72‐4 showed no significant difference between the natural and stimulated ovarian cycle groups (p≥0.5989). On average the mean PAPP‐A of the natural group was 2.41±0.58 mIU/L higher than the stimulated group (t = 4.10, p < 0.001). CA125 and CA15‐3 results were both significantly influenced by the stage of the cycle (p= In conclusion, batch analysis of all samples from each of the participants was conducted to maximise the possibility that any changes seen in biomarker concentrations were due to biological fluctuations and not because of assay variability. Ovarian stimulation reduced serum PAPP‐A levels, whilst CA125 and CA15‐3 were unaffected by ovarian stimulation per se but showed cyclical changes throughout both natural and stimulated cycles. PAPP‐A, CA125, tPSA and CA15‐3 all showed consistent changes in early pregnancy, and their combined benefits as markers of different aspects of implantation, embryogenesis and placentation warrants further investigation. Only CA125 in early pregnancy crossed the cut‐off associated with disease, ie ovarian cancer, and other gynaecological and inflammatory conditions. Care must therefore be taken when using CA125 determinations to detect disease if the woman is less than 7 weeks pregnant as transient elevations during this time appear normal.
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Woods, Nicole Natasha Brooks Lee R. "The role of biomedical knowledge in medical diagnosis by learners." *McMaster only, 2005.

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Meiklejohn, Barbara A. "Ektachem evaluation /." Online version of thesis, 1985. http://hdl.handle.net/1850/9634.

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Wabomba, Mukire John. "Signal and Image Processing Techniques for Environmental and Clinical Applications of Infrared Spectroscopy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040131767.

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Carberry, Helen. "Semiotic analysis of clinical chemistry: for "knowledge work" in the medical sciences." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15809/1/Helen_Carberry_Thesis.pdf.

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In this thesis a socio-cultural perspective of medical science education is adopted to argue the position that undergraduate medical scientists must be enculturated into the profession as knowledge workers and symbolic analysts who can interact with computers in complex analytical procedures, quality assurance and quality management. The cue for this position is taken from the transformations taking place in the pathology industry due to advances in automation, robotics and informatics. The rise of Evidence-Based Laboratory Medicine (EBLM) is also noted and the observation by higher education researchers, that knowledge systems are transforming in such a way that disciplines can no longer act in isolation. They must now collaborate with disparate fields in transdisciplinary knowledge systems such as EBLM, for which new skills must be cultivated in undergraduate medical scientists. This thesis aims to describe a theoretical basis for knowledge work by taking a semiotic perspective. This is because, semiotics, a theory of signs and representations, can be applied to the structure of transdisciplinary scientific knowledge, the logic of scientific practice and the rhetoric of scientific communications. For this purpose, a semiotic framework is first derived from a wide range of semiotic theories existent in the literature. Then the application of this semiotic framework to clinical chemistry knowledge, context, logic, and rhetoric is demonstrated. This is achieved by interpreting various clinical chemistry data sources, for example, course materials, laboratory spatial arrangements, instruments, printouts, and students' practical reports, collected from a teaching laboratory situation. The results of semiotic analysis indicate that the clinical chemist working in the computerised laboratory environment performs knowledge work, and the term is synonymous with symbolic analysis. It is shown that knowledge work entails the application of a systematic structure for clinical chemistry knowledge derived in terms of the validation procedures applied to laboratory, data, results and tests; the application of logic in the classification and selection of instruments, their rule governed- use, and in troubleshooting errors; pragmatic decisions based on availability of space, services and budgets; discrimination among values in laboratory test evaluations in EBLM, for the cost-effectiveness and relevance of pathology services; and the recognition of rhetorical strategies used to communicate laboratory test information in graphs, charts, and statistics. The role of the laboratory context is also explained through semiotics, in terms of its spatial arrangements and designs of laboratory instruments, as a place that constrains the knowledge work experience. This contextual analysis provides insights into the oppositional trend brought to wide attention by analysts of computerised professional work, that more skills are needed, but that there are fewer highly skilled positions available. The curriculum implications of these findings are considered in terms of the need to cultivate knowledge workers for highly complex symbolic analysis in computerised laboratories; and also the need to prepare medical science graduates for the transdisciplinary knowledge system of EBLM, and related venues of employment such as biomedical research and clinical medicine. In meeting the aims to define and demonstrate knowledge work from the semiotic perspective, this thesis makes an original contribution to knowledge by the application of semiotics to a field in which it has probably never been tested. It contributes to the scholarship of teaching in higher education by formulating a structure for transdisciplinary medical science knowledge, which integrates scientific with other forms of knowledge, and with real world practice.
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Carberry, Helen. "Semiotic analysis of clinical chemistry: for " knowledge work " in the medical sciences." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15809/.

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Abstract In this thesis a socio-cultural perspective of medical science education is adopted to argue the position that undergraduate medical scientists must be enculturated into the profession as knowledge workers and symbolic analysts who can interact with computers in complex analytical procedures, quality assurance and quality management. The cue for this position is taken from the transformations taking place in the pathology industry due to advances in automation, robotics and informatics. The rise of Evidence-Based Laboratory Medicine (EBLM) is also noted and the observation by higher education researchers, that knowledge systems are transforming in such a way that disciplines can no longer act in isolation. They must now collaborate with disparate fields in transdisciplinary knowledge systems such as EBLM, for which new skills must be cultivated in undergraduate medical scientists. This thesis aims to describe a theoretical basis for knowledge work by taking a semiotic perspective. This is because, semiotics, a theory of signs and representations, can be applied to the structure of transdisciplinary scientific knowledge, the logic of scientific practice and the rhetoric of scientific communications. For this purpose, a semiotic framework is first derived from a wide range of semiotic theories existent in the literature. Then the application of this semiotic framework to clinical chemistry knowledge, context, logic, and rhetoric is demonstrated. This is achieved by interpreting various clinical chemistry data sources, for example, course materials, laboratory spatial arrangements, instruments, printouts, and students' practical reports, collected from a teaching laboratory situation. The results of semiotic analysis indicate that the clinical chemist working in the computerised laboratory environment performs knowledge work, and the term is synonymous with symbolic analysis. It is shown that knowledge work entails the application of a systematic structure for clinical chemistry knowledge derived in terms of the validation procedures applied to laboratory, data, results and tests; the application of logic in the classification and selection of instruments, their rulegoverned- use, and in troubleshooting errors; pragmatic decisions based on availability of space, services and budgets; discrimination among values in laboratory test evaluations in EBLM, for the cost-effectiveness and relevance of pathology services; and the recognition of rhetorical strategies used to communicate laboratory test information in graphs, charts, and statistics. The role of the laboratory context is also explained through semiotics, in terms of its spatial arrangements and designs of laboratory instruments, as a place that constrains the knowledge work experience. This contextual analysis provides insights into the oppositional trend brought to wide attention by analysts of computerised professional work, that more skills are needed, but that there are fewer highly skilled positions available. The curriculum implications of these findings are considered in terms of the need to cultivate knowledge workers for highly complex symbolic analysis in computerised laboratories; and also the need to prepare medical science graduates for the transdisciplinary knowledge system of EBLM, and related venues of employment such as biomedical research and clinical medicine. In meeting the aims to define and demonstrate knowledge work from the semiotic perspective, this thesis makes an original contribution to knowledge by the application of semiotics to a field in which it has probably never been tested. It contributes to the scholarship of teaching in higher education by formulating a structure for transdisciplinary medical science knowledge, which integrates scientific with other forms of knowledge, and with real world practice.
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Bani, Rashaid Ayat H. "Clinical and Forensic Biomarkers in Human Hair." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407256298.

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Wang, Yin 1951. "Influences of membrane biophysical properties on the Metarhodopsin I to Metarhodopsin II transition in visual excitation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282520.

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Current biophysical studies of membrane proteins are centered on the relation of their structures to key biological functions of membranes in terms of lipid-protein interactions. The conformational transition of rhodopsin from Metarhodopsin I to Metarhodopsin II (Meta I-Meta II) is the triggering event for the visual process. Meta II is the activated form of the visual receptor and binds a signal transducing G protein (transducin), followed by two amplification stages which lead to generation of a visual nerve impulse. Herein, flash photolysis and surface plasmon resonance (SPR) spectroscopy techniques have been used to monitor the Meta I-Meta II transition of rhodopsin in various membrane recombinants. The flash photolysis experiments clearly show a substantial shift to the left of the Meta I-Meta II equilibrium for rhodopsin in egg phosphatidylcholine recombinant membranes. Investigation of the influences on rhodopsin function by non-lamellar forming lipids reveals a characteristic relationship between the Gibbs free energy change for the Meta I-Meta II equilibrium of rhodopsin and the intrinsic curvature of the lipid bilayer. Complementary SPR studies suggest a protrusion of the protein at the activated Meta II state which may be associated with exposure of recognition sites for the signal transducing G protein on the cytoplasmic surface of rhodopsin. All the experimental results obtained here are consistent with the hypothesis of a new flexible surface biomembrane model. The Meta II state is favored by a negative spontaneous curvature of the bilayer, corresponding to an imbalance of the lateral forces within the polar head groups and acyl chains. The mean curvature of membrane bilayer in the Meta II state reflects the small spontaneous curvature of the lipid bilayer in the vicinity of protein. Relief of the lipid curvature frustration in the Meta II state energetically couples the lipids to the photoexcitation of rhodopsin. Consideration of the various energetic contributions suggests the bilayer curvature free energy provides a reservoir of work in the modulation of rhodopsin function in the visual process. These studies that biophysical properties of the liquid-crystalline lipid bilayer are important in relation to protein function and may be relevant to the biomedical investigations of visual dysfunction.
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Persson, Johanna. "Hälsoundervisning : Elevers syn på hälsa inom ämnet Idrott och hälsa." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2478.

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Fler unga människor än någonsin är idag överviktiga och stress och stressrelaterade symptom drabbar idag allt fler unga. Därför är det viktigt att unga människor får kunskaper om hur de på bästa sätt kan ta hand om sig själva.

 Syftet med detta arbete är att undersöka hur elever som läser gymnasiets kurs Idrott och hälsa A ser på den hälsoundervisning de får.

Detta är relevant för alla som arbetar som idrott och hälsa lärare för att kunna hitta en jämkning mellan kursplan och elevernas tankar och förkunskaper.

 Genom intervjuer och fokusintervjuer kom jag fram till att eleverna vill lära sig mer om stress och hur man hanterar stress samt om kost. Eleverna tycker däremot att idrottsläraren inte är rätt person att lära ut kunskaper om tobak.

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Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

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Books on the topic "Medical Biochemistry and Clinical Chemistry"

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Medical biochemistry. 4th ed. San Diego: Harcourt/Academic Press, 2001.

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Adam, Greenstein, ed. Medical biochemistry at a glance. Oxford: Blackwell Science, 1996.

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Makowski, Gregory S. Advances in Clinical Chemistry. Amsterdam: Elsevier/Academic Press, 2011.

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J, Beckett G., ed. Lecture notes. 7th ed. Malden, Mass: Blackwell Pub., 2005.

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M, Ayling Ruth, and Wicks Claire, eds. Biochemisty for clinical medicine. London: Greenwich Medical Media, 2001.

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H, White G., ed. A guide to diagnostic clinical chemistry. 3rd ed. Oxford: Blackwell Scientific Publications, 1994.

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R, Watkinson L., and Koay E. S. C, eds. Cases in chemical pathology: A diagnostic approach. 3rd ed. Singapore: World Scientific, 1992.

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A, Harvey Richard, ed. Biochemistry. 3rd ed. Philadelphia: Lippincott/Williams & Wilkins, 2005.

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Champe, Pamela C. Biochemistry. Philadelphia: Lippincott, 1987.

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A, Harvey Richard, ed. Biochemistry. Philadelphia: J.B. Lippincott, 1994.

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Book chapters on the topic "Medical Biochemistry and Clinical Chemistry"

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Müller, Mathias M. "Clinical Biochemistry of Gout." In Clinical Chemistry, 257–66. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_24.

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Marks, Vincent. "Clinical Biochemistry — An Integrated Service." In Clinical Chemistry, 311–17. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_29.

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Kanagasabapathy, A. S., and S. Swaminathan. "Clinical Biochemistry Services in India." In Clinical Chemistry, 825–32. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_85.

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Suhadi, F. X. Budhianto. "Clinical Biochemistry Services in Indonesia." In Clinical Chemistry, 833–40. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_86.

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Osotimehin, Babatunde. "Clinical Biochemistry Services in Tropical Africa." In Clinical Chemistry, 815–24. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_84.

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Bergveld, P., and P. J. A. van der Starre. "Biosensors for Medical Use." In Clinical Chemistry, 113–20. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_12.

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Tan, It-Koon. "Clinical Biochemistry in Developing Countries in Asia." In Clinical Chemistry, 799–814. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_83.

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Greiling, H., R. Reinards, and K. Kleesiek. "Clinical Biochemistry of Connective Tissue and its Role in Ageing." In Clinical Chemistry, 447–53. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_45.

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von Beust, Barbara R., and Gregory S. Travlos. "Biochemistry of Immunoglobulins." In The Clinical Chemistry of Laboratory Animals, 551–86. Third edition. | Boca Raton : Taylor & Francis, 2017.: CRC Press, 2017. http://dx.doi.org/10.1201/9781315155807-16.

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Chatterjea, MN, and Rana Shinde. "Cerebrospinal Fluid (CSF)—Chemistry and Clinical Significance." In Textbook of Medical Biochemistry, 725. Jaypee Brothers Medical Publishers (P) Ltd., 2012. http://dx.doi.org/10.5005/jp/books/11486_42.

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Conference papers on the topic "Medical Biochemistry and Clinical Chemistry"

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Кіндрат, Ірина. "CLINICAL CASE BASED LEARNING AS AN INNOVATIVE METHOD FOR TEACHING BIOCHEMISTRY IN MEDICAL UNIVERSITY." In LE TENDENZE E MODELLI DI SVILUPPO DELLA RICERСHE SCIENTIFICI. European Scientific Platform, 2020. http://dx.doi.org/10.36074/13.03.2020.v2.17.

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Kaksis, Aris, Agnese Brangule, and Mihails Halitovs. "AN APPROACH TO TEACHING MEDICAL CHEMISTRY THAT HIGHLIGHTS INTERDISCIPLINARY NATURE OF SCIENCE." In 1st International Baltic Symposium on Science and Technology Education. Scientia Socialis Ltd., 2015. http://dx.doi.org/10.33225/balticste/2015.54.

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Abstract:
Thermodynamics is a branch of physics that deals with questions concerning energies and work of a system. It is one of the key topics for understanding processes in the universe as well as any separate system like a gas mixture or a single cell in a biological system. Thermodynamics is included in the university curriculum for engineering, chemistry and physics students as well as medical student curriculum. This paper outlines the problems faced by first year medical students learning thermodynamics at Riga Stradinš University. We describe a medically relevant context based approach to teaching that demonstrates the interdisciplinary nature of medical chemistry, molecular biology and biochemistry. Our method provides a model in which disciplinary barriers are diminished and increased effectiveness of teaching is achieved. Key words: interdisciplinary teaching, medical chemistry, thermodynamics, teaching and learning thermodynamics.
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Chakrabarty, Krishnendu. "Digital Microfluidics: Connecting Biochemistry to Electronic System Design." In ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2007. http://dx.doi.org/10.1115/icnmm2007-30158.

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Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassays, blood chemistry for clinical diagnostics, DNA sequencing, and environmental sensing. The complexity of microfluidic devices, also referred to as lab-on-a-chip, is expected to become significant in the near future due to the need for multiple and concurrent biochemical assays on multifunctional and reconfigurable platforms. This paper provides an overview of droplet-based “digital” microfluidic biochips. It presents early work on top-down system-level computer-aided design (CAD) tools for the synthesis, testing and reconfiguration of microfluidic biochips. These CAD techniques allow the biochip to concentrate on the development of the nano- and micro-scale bioassays, leaving assay optimization and implementation details to design automation tools.
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Chen, Wen, Chao Xu, Ming Zeng, and Jianbo Zhou. "Medical Organic Chemistry Teaching Reform Initiatives behind Clinical Professional Certification." In 2016 5th International Conference on Social Science, Education and Humanities Research. Paris, France: Atlantis Press, 2016. http://dx.doi.org/10.2991/ssehr-16.2016.177.

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Rumyantsev, Yegor Y., Tatiana I. Okonenko, Kseniya Y. Kartysheva, Galina A. Antropova, and Svetlana V. Merbakh. "Biomarkers of clinical course in covid-19 patients with cardiovascular comorbidity." In Innovations in Medical Science and Education. Dela Press Publishing House, 2022. http://dx.doi.org/10.56199/dpcsms.vyxd9415.

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A new coronavirus infection (COVID-19) tends to have severe course in patients with cardiovascular disease, with routine laboratory tests predicting adverse outcomes in such patients. The results of studies of interplaying factors are contradictory and require further investigation. The aim was to analyze the parameters of general blood analysis, inflammatory response, cholesterol and hemostasis in the groups of patients who underwent COVID-19-associated pneumonia with cardiovascular comorbidity. The study was conducted in Veliky Novgorod from December 2020 to April 2022 during inpatient treatment of patients diagnosed with COVID-19-associated novel coronavirus infection. We analyzed 108 case histories of patients. The patient’s data was divided into 2 groups. Group I consisted of 86 patients with cardiovascular diseases at the time of admission. The control group consisted of 22 patients without concomitant cardiovascular diseases. The data of general blood analysis, biochemistry and hemostasis were assessed on the day of admission and on the day of discharge. Results. Average bed-days of patients with cardiovascular pathology were longer than in the control group; in addition, there was a correlation of the duration of hospitalization and CRP level with the initial level of total cholesterol. Also, positive correlation of CRP level with blood fibrinogen content was found, which was more expressed in patients with cardiovascular comorbidity. Conclusions. The results of our study, in general, do not contradict the results accumulated in the world. Those findings should be compared with other studies and to monitor COVID-19 disease trends.
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Ulgen, Yekta. "A Practical Approach to ISO 15189 and Measurement Uncertainty in Clinical Chemistry: Analytic Bias is Still an Important Challenge." In 2019 IEEE International Symposium on Medical Measurements and Applications (MeMeA). IEEE, 2019. http://dx.doi.org/10.1109/memea.2019.8802171.

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Reports on the topic "Medical Biochemistry and Clinical Chemistry"

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Terah, Elena Igorevna. The work program, guidelines and evaluation materials of the discipline «Inorganic Chemistry» for students of the specialty «Medical Biochemistry». Novosibirsk State Medical University, 2020. http://dx.doi.org/10.12731/inorganicchemistry-terahelena.

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