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Journal articles on the topic 'Medical liver damage'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Aripov, A. N., O. A. Aripov, L. L. Akhunjanova, A. O. Nabiev, D. A. Nabieva, and T. T. Khamroev. "STUDY THE ANTIFIBROUS EFFICACY OF PLANT PROANTHOCYANIDIN IN RATS WITH CHRONIC HELIOTRINE LIVER DAMAGE." Frontline Medical Sciences and Pharmaceutical Journal 02, no. 05 (2022): 16–25. http://dx.doi.org/10.37547/medical-fmspj-02-05-03.

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Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn plant (Alhagi pseudalhagi) – Yantacin, when administered orally at a dose of 100 mg / kg, on possible changes in the early stages of liver fibrosis that occurred against the background of chronic heliotrine hepatitis was studied. The studies were conducted on male rats with a body weight of 100 ±10 g. The effect of yantacin on the general and biochemical parameters of the blood, as well as the amount of NO – nitrates (in connection with lipoproteins), proteins in the blood against the bac

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Williams, Jessica A., Hong-Min Ni, Yifeng Ding, and Wen-Xing Ding. "Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 309, no. 5 (2015): G324—G340. http://dx.doi.org/10.1152/ajpgi.00108.2015.

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Alcoholic liver disease claims two million lives per year. We previously reported that autophagy protected against alcohol-induced liver injury and steatosis by removing damaged mitochondria. However, the mechanisms for removal of these mitochondria are unknown. Parkin is an evolutionarily conserved E3 ligase that is recruited to damaged mitochondria to initiate ubiquitination of mitochondrial outer membrane proteins and subsequent mitochondrial degradation by mitophagy. In addition to its role in mitophagy, Parkin has been shown to have other roles in maintaining mitochondrial function. We in

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Khvan, O. I., A. N. Don, Kh Kh Yakubov, and T. K. Nasyrov. "PECULIARITIES OF FORENSIC MEDICAL ASSESSMENT OF LIVER, SPLEEN AND KIDNEY DAMAGE DURING A FALL FROM HEIGHT." International Journal of Medical Sciences And Clinical Research 03, no. 02 (2023): 26–31. http://dx.doi.org/10.37547/ijmscr/volume03issue02-06.

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The article reflects the data of an expert assessment of blunt abdominal trauma in a fall from a height. It is especially important to find out the circumstances of the injury in order to have an idea of possible damage to the hollow and parenchymal organs of the abdominal cavity. According to the conducted studies, when falling from a height, characteristic damage was established, depending on the height of the fall.

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Cardin, R., M. Piciocchi, and F. Farinati. "Letter: coffee and chronic liver damage." Alimentary Pharmacology & Therapeutics 39, no. 6 (2014): 643. http://dx.doi.org/10.1111/apt.12637.

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Sayfullin, M. A., N. N. Zvereva, E. A. Nurmuhametova, et al. "Liver damage with measles." Journal Infectology 12, no. 4 (2020): 78–86. http://dx.doi.org/10.22625/2072-6732-2020-12-4-78-86.

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Objective: to determine the incidence of liver damage with measles, the specificity of these changes, to identify risk groups, to assess the dynamics of the development of hyperfermentemia in various stages of the disease.Materials and methods: a retrospective cohort study of medical records of patients hospitalized with measles (n = 101), divided into 4 groups: children (n = 23), men (n = 32), women (n = 24) and pregnant women (n = 22). Patients with laboratory-confirmed influenza (n = 61) were taken as a comparison group. The analysis of the frequency of detecting changes in biochemical para

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Ahsan, Naveed, Sarwat Jahan, Sana Imran, and Naveed Ahsan. "ISONIAZID INDUCED LIVER DAMAGE." Professional Medical Journal 25, no. 07 (2018): 1124–28. http://dx.doi.org/10.29309/tpmj/2018.25.07.159.

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Objectives: To observe healthy effects of silymarin on liver histopathology againstliver damage, caused by isoniazid in rabbits. Study Design: Interventional study. Setting:Animal House of Jinnah Postgraduate Medical Centre, Karachi. Period: April to September2013. Methods: Total 28 rabbits of weight 1-1.5kg of either sex were used in this study. Whichwere divided randomly into four equal groups: Group I was control group. In group II silymarin(50mg/kg/day orally) was administered, in group III isoniazid (50mg/kg/dayorally) was given;and in group IV, effects of combination therapy of isoniazid

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Meng, Qinghong, Na Li, Lianmei Yuan, and Xiaona Gao. "Analysis of common causes of liver damage among children 12 years and younger in Weifang." Journal of International Medical Research 49, no. 4 (2021): 030006052110066. http://dx.doi.org/10.1177/03000605211006661.

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Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most co

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Kayalı, Ahmet, Ejder Saylav Bora, Hüseyin Acar, and Oytun Erbaş. "Evaluation of the Reparative Effect of Sinomenine in an Acetaminophen-Induced Liver Injury Model." Current Issues in Molecular Biology 46, no. 1 (2024): 923–33. http://dx.doi.org/10.3390/cimb46010059.

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Due to its rising global prevalence, liver failure treatments are urgently needed. Sinomenine (SIN), an alkaloid from sinomenium acutum, is being studied for its liver-repair properties due to Acetaminophen (APAP) overdose. SIN’s effect on APAP-induced hepatotoxicity in rats was examined histologically and biochemically. Three groups of 30 adult male Wistar rats were created: control, APAP-only, and APAP + SIN. Histopathological and biochemical analyses were performed on liver samples after euthanasia. SIN is significantly protected against APAP damage. Compared to APAP-only, SIN reduced cellu

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Batt, A. M., and L. Ferrari. "Manifestations of chemically induced liver damage." Clinical Chemistry 41, no. 12 (1995): 1882–87. http://dx.doi.org/10.1093/clinchem/41.12.1882.

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Abstract Possible liver damage induced by chemicals or drugs must be detected early during drug development or industrial exposure, although damage is still difficult to predict, especially when immunotoxicity is involved. Liver toxicity may result from cytolysis, steatosis, cholestasis, phospholipidosis, or vascular lesions, most the outcome of a disadvantageous balance between chemicals or metabolites vs protective mechanisms, resulting from chemical dosage, genetic factors, or the immunoallergic status of the patient. Drug metabolism, lipid peroxidation, and thiol oxidation are frequently i

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Gopchuk, E. N. "Medicated liver damage during pregnancy." HEALTH OF WOMAN, no. 9(145) (November 30, 2019): 43–49. http://dx.doi.org/10.15574/hw.2019.145.43.

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The significant frequency of drug-related liver damage during pregnancy, the lack of unified approaches to forecasting issues, the standards for diagnosis and drug correction, as well as the underestimation of the risk of disease for pregnancy outcomes characterize this problem as highly relevant and significant for modern obstetrics. Any drugs in a pregnant woman can cause drug hepatitis, so all of them should be prescribed to pregnant women only for strict clinical indications. In this case, one should take into account the genetic predisposition, history and risk factors for the development

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Petrovic-Subic, Narcisa, Miroslav Kojic, Slobodan Jankovic, and Srdjan Stefanovic. "Performance of a calculator for diagnosing the cause of liver damage." Srpski arhiv za celokupno lekarstvo 147, no. 1-2 (2019): 27–33. http://dx.doi.org/10.2298/sarh180504064p.

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Introduction/Objective. Making a calculator that would recognize patterns of abnormal liver function tests and link them to the most probable etiology could help clinicians in their initial orientation towards a definitive diagnosis in patients with liver damage. The aim of our study was to design, construct, and validate a calculator that based on a pattern of abnormalities in liver function tests of a patient with liver damage would propose the most probable etiology. Methods. Patterns of abnormal liver function tests for certain etiology of liver damage were extracted from distributions of

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Cione, Erika, Diana Marisol Abrego Guandique, Maria Cristina Caroleo, Filippo Luciani, Manuela Colosimo, and Roberto Cannataro. "Liver Damage and microRNAs: An Update." Current Issues in Molecular Biology 45, no. 1 (2022): 78–91. http://dx.doi.org/10.3390/cimb45010006.

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One of the major organs in the body with multiple functions is the liver. It plays a central role in the transformation of macronutrients and clearance of chemicals and drugs. The serum biomarkers often used to indicate liver damage are not specifically for drug-induced liver injury (DILI) or liver injury caused by other xenobiotics, nor for viral infection. In this case, microRNAs (miRNAs) could play an exciting role as biomarkers of specific liver damage. In this review, we aimed to update the current literature on liver damage induced by drugs, as acute conditions and viral infections media

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Bilzer, Manfred, Hartmut Jaeschke, Angelika M. Vollmar, Gustav Paumgartner, and Alexander L. Gerbes. "Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide." American Journal of Physiology-Gastrointestinal and Liver Physiology 276, no. 5 (1999): G1137—G1144. http://dx.doi.org/10.1152/ajpgi.1999.276.5.g1137.

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The generation of reactive oxygen species (ROS) by activated Kupffer cells contributes to liver injury following liver preservation, shock, or endotoxemia. Pharmacological interventions to protect liver cells against this inflammatory response of Kupffer cells have not yet been established. Atrial natriuretic peptide (ANP) protects the liver against ischemia-reperfusion injury, suggesting a possible modulation of Kupffer cell-mediated cytotoxicity. Therefore, we investigated the mechanism of cytoprotection by ANP during Kupffer cell activation in perfused rat livers of male Sprague-Dawley rats

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García‐Román, Rebeca, and Rubén Francés. "Acetaminophen‐Induced Liver Damage in Hepatic Steatosis." Clinical Pharmacology & Therapeutics 107, no. 5 (2019): 1068–81. http://dx.doi.org/10.1002/cpt.1701.

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Bengtsson, Finn, Claes-Henrik Florén, Inga Hàerstrand, Claes Söderström, and Thomas Åberg. "Flucloxacillin-induced Cholestatic Liver Damage." Scandinavian Journal of Infectious Diseases 17, no. 1 (1985): 125–28. http://dx.doi.org/10.3109/00365548509070433.

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Salvadori, Maurizio, and Aris Tsalouchos. "Liver Transplantation for Monogenic Metabolic Diseases Involving the Kidney." Journal of Renal and Hepatic Disorders 1, no. 2 (2017): 29–40. http://dx.doi.org/10.15586/jrenhep.2017.18.

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Several metabolic monogenic diseases may be cured by liver transplantation alone (LTA) or by combined liver–kidney transplantation (CLKT) when the metabolic disease has caused end-stage renal disease. Liver transplantation may be regarded as a substitute for an injured liver or as supplying a tissue that may replace a mutant protein. Two groups of diseases should be distinguished. In the first group, the kidney tissue may be severely damaged while the liver tissue is almost normal. In this group, renal transplantation is recommended according to the degree of renal damage and liver transplanta

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Montori, Michele, Gialuca Svegliati Baroni, Pierangelo Santori, et al. "Liver Damage and COVID-19: At Least a “Two-Hit” Story in Systematic Review." Current Issues in Molecular Biology 45, no. 4 (2023): 3035–47. http://dx.doi.org/10.3390/cimb45040199.

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COVID-19 pandemic waves have hit on our lives with pulmonary and, also, gastrointestinal symptoms. The latter also includes acute liver damage linked to direct SARS-CoV-2 action and/or drug-induced (DILI) in the frame of pre-existing chronic liver disease. We aimed to review literature data regarding liver damage during COVID-19. We conducted a systematic search on the main medical databases for original articles, reviews, meta-analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: liver disease, COVID-19, acute liver damage, drug

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Lei, Xiang, Jing Chen, Jingtian Ren, et al. "Liver Damage Associated withPolygonum multiflorumThunb.: A Systematic Review of Case Reports and Case Series." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/459749.

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Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated withPolygonum multiflorumThunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW.Methods. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included.Results. This review covers a total of 450 cases in 76 articles. HSW types included raw and processed HSW decoction pieces and man

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Marinkovic, Nadica, Zivorad Malicevic, and Jovan Dimitrijevic. "Ambient temperature impact on hepatocellular liver damage in rats following intake of 3,4-methylenedioxymethamphetamine." Vojnosanitetski pregled 68, no. 7 (2011): 561–66. http://dx.doi.org/10.2298/vsp1107561m.

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Bacground/Aim. 3,4-methylendioxymethamphetamine (MDMA, Ecstasy) is a psycho-stimulating agent. It is usualy taken orally in the form of tablets. It is absorbed throught the gastrointestinal mucous membrane. Hyperthermia is the most prominent clinical sign of MDMA intake. The most prominent forensic finding of lethal MDMA poisoning is myocardial infarction and cerebrovascular bleeding. However, liver and kidney damage: have also been described. The aim of this research was to determine if ambient temperatures affect liver damage in the experimental rats. Methods. The experiment was conducted fo

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Jia, Jinchao, Luyu Yang, Zhujun Cao, et al. "Neutrophil-derived lipocalin-2 in adult-onset Still’s disease: a novel biomarker of disease activity and liver damage." Rheumatology 60, no. 1 (2020): 304–15. http://dx.doi.org/10.1093/rheumatology/keaa368.

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Abstract Objective Liver damage is a common manifestation and can be life-threatening in adult-onset Still’s disease (AOSD), an autoinflammatory disease. The hallmark of AOSD is activation of neutrophils, whose infiltration in liver is suspected to promote tissue injury. Here we aimed to identify a candidate biomarker and to validate its association with liver damage in AOSD. Methods Transcriptome analysis of neutrophils from treatment-naïve active AOSD patients and healthy donors was performed. Lipocalin-2 (LCN2) expression was assessed in neutrophils, plasma and liver biopsies of AOSD. The c

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Tsema, Ievgen, Igor Khomenko, Vitalii Shapovalov, et al. "Surgical treatment of combined thoraco-abdominal injury of liver with the mechanism of the hydrodynamic shock (case report)." Journal of Medical Science 86, no. 3 (2017): 240. http://dx.doi.org/10.20883/jms.2017.227.

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This article presents a clinical case of successful multilevel treatment the combined gunshot wound of liver with the mechanism of hydrodynamic shock using «damage control» tactic. The patient received a combined thoraco‑abdominal injured as a result of warfare on the east of Ukraine. The blind fragmental penetrating trauma of the chest cavity led to the rupture of the right dome of diaphragm and liver (S3–S6) by the mechanism of hydrodynamic kick (fragments the wreckage and input/output openings in the abdominal cavity were not found). The «damage control» tactic was implemented as follows. O

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Santos, Ehebha Ehizokhale, Efe Endurance Ahama, Chinenye Praise Glorious, Kennedy Oberhiri Obohwemu, Ochuko Peace Amromare, and Omashim Kaine. "HISTOLOGICAL EFFECTS OF CHRONIC CONSUMPTION OF ACTION BITTERS ON THE LUNGS, LIVER AND KIDNEYS OF ADULT MALE WISTAR RATS." Frontline Medical Sciences and Pharmaceutical Journal 04, no. 12 (2024): 21–42. https://doi.org/10.37547/medical-fmspj-04-12-03.

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Introduction: Action bitters, commonly used in traditional medicine, have an unclear safety profile and potential effects on lung, liver, and kidney tissues. This experimental study investigated the histological effects of action bitters on the lungs, liver, and kidney tissues of adult male Wistar rats. Understanding these effects is crucial, as it can provide insights into the safety and potential risks associated with the use of action bitters in traditional medicine. Methodology: A total of 18 adult male rats were used in this study. The rats were divided into three groups, each consisting

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Klune, John R., Rajeev Dhupar, Shoko Kimura, et al. "Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 5 (2012): G666—G673. http://dx.doi.org/10.1152/ajpgi.00050.2012.

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Interferon regulatory factor (IRF)-1 is a nuclear transcription factor that induces inflammatory cytokine mediators and contributes to hepatic ischemia-reperfusion (I/R) injury. No strategies to mitigate IRF1-mediated liver damage exist. IRF2 is a structurally similar endogenous protein that competes with IRF1 for DNA binding sites in IRF-responsive target genes and acts as a competitive inhibitor. However, the role of IRF2 in hepatic injury during hypoxic or inflammatory conditions is unknown. We hypothesize that IRF2 overexpression may mitigate IRF1-mediated I/R damage. Endogenous IRF2 is ba

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Chesca, Antonella, Tim Sandle, and Galiya Abdulina. "Considerations regarding liver current pathology." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 102, no. 2 (2021): 84–88. http://dx.doi.org/10.31489/2021bmg2/84-88.

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This work presents reasoning about liver pathology. Liver pathology is an area of interest due to the growing number of medical cases worldwide. The factors associated with the appearance of this pathology are those that relate to individual lifestyle. Liver pathology studies are performed up to the biomolecular level, involving cytochrome P450 2E1 (CYP2E1). With a normal liver, subject to aging and the aforementioned risk factors, there are changes in liver structure, which often can lead to changes arising from nonalcoholic hepatic steatosis (NASH). Under certain circumstances this degenerat

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Litvinova, Ekaterina S., Nikolay N. Konoplya, Anastasiya A. Shulginova, and Anastasiya V. Kharchenko. "Proteins of allogeneic hepatocytes and pharmacological preparations for the correction of immunometabolic disorders in experimental liver pathology." Research Results in Pharmacology 7, no. 2 (2021): 83–99. http://dx.doi.org/10.3897/rrpharmacology.7.70314.

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Introduction: The relationship of numerous metabolic shifts, disorders of hepatocytes functional activity resulting from hypoxia and toxic liver damage with the function of the immune system has not been sufficiently studied so far, nor have the most effective methods of pharmacological correction been established. Materials and Methods: The studies were carried out on 603 mature male Wistar rats and 45 mice. Acute toxic liver damage (ATLD) was modeled by intramuscular introduction of carbon tetrachloride; acute liver ischemia (ALI) was caused by clamping the hepatoduodenal ligament for 20 min

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Shen, Kunlu, Yu Gu, Yu Wang, et al. "Therapeutic drug monitoring and safety evaluation of voriconazole in the treatment of pulmonary fungal diseases." Therapeutic Advances in Drug Safety 13 (January 2022): 204209862211275. http://dx.doi.org/10.1177/20420986221127503.

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Aims: The gene polymorphism of voriconazole metabolism–related liver enzyme is notable in East Asia population. It casts a significant influence on the rational use of voriconazole. We conducted this study to investigate the relationship between steady-state voriconazole trough concentration (Ctrough) and adverse effects (AEs), especially hepatotoxicity. Methods: We conducted a real-world study in the Jinling Hospital from January 2015 to June 2020. A total of 140 patients receiving voriconazole were enrolled in this study. The determination and scoring of voriconazole-associated hepatotoxicit

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Wu, Liwei, Qiang Yu, Ping Cheng та Chuanyong Guo. "PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway". PPAR Research 2021 (3 липня 2021): 1–15. http://dx.doi.org/10.1155/2021/6626295.

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Background. Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. Aim. In this study, we explored the potential mechanism of PPARγ in the pathogenesis of hepatic IR injury by mice model. Methods. After treated with si-PPARγ or rosiglitazone, mice were subjected to hepatic ischemia-reperfusion. Liver tissue and blood samples were collected to evaluate liver injury and detected relative mRNA and protein expre

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Lau, Johnson Yiu-Nam. "IV. Pathogenetic mechanisms involved in hepatitis C virus-induced liver diseases." American Journal of Physiology-Gastrointestinal and Liver Physiology 275, no. 6 (1998): G1217—G1220. http://dx.doi.org/10.1152/ajpgi.1998.275.6.g1217.

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The pathogenetic mechanisms for liver damage in acute hepatitis C are not clear, but a host immune cellular response may be involved. In chronic hepatitis C, there is strong evidence that host cellular immune response is involved in the control of viral replication and contributes to hepatocellular damage. As hepatitis C virus infection persists, continuous liver damage and regeneration, together with enhanced fibrogenesis, may eventually lead to cirrhosis in a proportion of patients. Transplant patients on high-dose immunosuppression may have high-level intrahepatic hepatitis C viral expressi

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Zeniya, M., A. Kuramoto, M. Hara, H. Takahashi, Y. Aizawa, and G. Toda. "Pathophisiology of liver damage in autoimmune hepatitis." Pathophysiology 1 (November 1994): 172. http://dx.doi.org/10.1016/0928-4680(94)90362-x.

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&NA;. "Minimising neurological damage takes priority in acute liver failure." Drugs & Therapy Perspectives 15, no. 7 (2000): 4–7. http://dx.doi.org/10.2165/00042310-200015070-00002.

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Chen, Ting, Timothy M. Moore, Mark T. W. Ebbert, et al. "Liver kinase B1 inhibits the expression of inflammation-related genes postcontraction in skeletal muscle." Journal of Applied Physiology 120, no. 8 (2016): 876–88. http://dx.doi.org/10.1152/japplphysiol.00727.2015.

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Skeletal muscle-specific liver kinase B1 (LKB1) knockout mice (skmLKB1-KO) exhibit elevated mitogen-activated protein kinase (MAPK) signaling after treadmill running. MAPK activation is also associated with inflammation-related signaling in skeletal muscle. Since exercise can induce muscle damage, and inflammation is a response triggered by damaged tissue, we therefore hypothesized that LKB1 plays an important role in dampening the inflammatory response to muscle contraction, and that this may be due in part to increased susceptibility to muscle damage with contractions in LKB1-deficient muscl

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Farhadi, Roya. "Hepatobiliary Involvement in Neonates With COVID-19 Infection: A Previous Case Series Studies." Journal of Pediatrics Review 11, no. 2 (2023): 125–34. http://dx.doi.org/10.32598/jpr.11.2.47.4.

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Background: The most common symptoms in neonates with severe COVID-19 infection have been respiratory problems. The virus may adversely affect organs such as the liver. Methods: Studies focusing solely on liver involvement in newborns with COVID-19 infection were searched in Pubmed, Scopus, and Google Scholar databases. Eight studies were finally reviewed. Results: Direct viral invasion (COVID-19-induced hepatitis or systemic inflammatory response) and drug-induced may contribute to liver damage in neonates. SARS-CoV-2 may be the latest spark in toxoplasmosis, other agents, rubella, cytomegalo

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Gao, Yanguo, Hongqiao Zhang, Hua Zhong, Suosuo Yang, and Qiuyan Wang. "Lactate and blood ammonia on admission as biomarkers to predict the prognosis of patients with acute mushroom poisoning and liver failure: a retrospective study." Toxicology Research 10, no. 4 (2021): 850–55. http://dx.doi.org/10.1093/toxres/tfab068.

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Abstract The diagnosis of liver damage induced by mushroom poisoning is still challenging. This study aims to screen the early biological indexes that could predict acute mushroom poisoning with liver damage. The patients with acute mushroom poisoning and liver damage admitted to The First Affiliated Hospital of Dalian Medical University，China from July 2007 to August 2017 were analyzed retrospectively. A total of 66 patients were enrolled in this study, with 44 and 22 patients in the liver injury group and liver failure group, respectively. Ten patients in the liver failure group died, with a

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Tomás-Zapico, Cristina, Óscar Álvarez-García, Verónica Sierra, et al. "Oxidative damage in the livers of senescence-accelerated mice: a gender-related response." Canadian Journal of Physiology and Pharmacology 84, no. 2 (2006): 213–20. http://dx.doi.org/10.1139/y05-111.

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The prevalence of liver diseases emphasizes the need of animal models to research on the mechanism of disease pathogenesis. Furthermore, most of the liver pathologies have the oxidative stress as an important component. The senescence-accelerated mouse strain SAMP8 was proposed as a valuable animal model for the study of liver diseases. To gain a better understanding of the mechanisms underlying degenerative processes in SAMP8 mice livers, we studied the oxidative-induced damage in 5-month-old SAMP8 mice and SAMR1, senescence-accelerated-resistant mice. We found profound differences in the ant

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Haider, Rehan. "Alcoholic Hepatitis." Journal of Clinical Research and Reports 15, no. 1 (2024): 01–11. http://dx.doi.org/10.31579/2690-1919/351.

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Alcoholic hepatitis is a serious liver condition characterized by inflammation and liver damage caused by excessive alcohol consumption. This condition represents a significant health concern worldwide as it can progress to more severe liver diseases, including cirrhosis and liver failure. This abstract provides an overview of alcoholic hepatitis, including its causes, symptoms, diagnosis, and treatment. Long-term alcohol consumption is the primary cause of alcoholic hepatitis. When alcohol is metabolized in the liver, it generates toxic byproducts that can lead to inflammation and cellular da

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Dritsas, Elias, and Maria Trigka. "Supervised Machine Learning Models for Liver Disease Risk Prediction." Computers 12, no. 1 (2023): 19. http://dx.doi.org/10.3390/computers12010019.

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The liver constitutes the largest gland in the human body and performs many different functions. It processes what a person eats and drinks and converts food into nutrients that need to be absorbed by the body. In addition, it filters out harmful substances from the blood and helps tackle infections. Exposure to viruses or dangerous chemicals can damage the liver. When this organ is damaged, liver disease can develop. Liver disease refers to any condition that causes damage to the liver and may affect its function. It is a serious condition that threatens human life and requires urgent medical

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Nazir Shah, Mian Mufarih Shah, Daneeth Kumar, Imran Qadir Khattak, and Imran Khan. "Hepatocellular Damage in the Patients presenting with Dengue Fever." Journal of Saidu Medical College, Swat 13, no. 1 (2023): 8–12. http://dx.doi.org/10.52206/jsmc.2023.13.1.765.

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Background: Dengue fever is becoming endemic in Pakistan as shown by its increasing prevalence in the summer seasons for almost the last decade. Elevation of liver enzymes indicating underlying liver damage, is a common phenomenon and may be associated with other complications. Objective: To find out the frequency of hepatocellular damage in the patients presenting with dengue fever as evident by elevated liver enzymes.Material and Methods: This was a descriptive study performed in the medical unit of Hayatabad Medical Complex Peshawar Pakistan. Patients were consecutively collected from the w

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von Montfort, Claudia, Juliane I. Beier, Luping Guo, J. Phillip Kaiser, and Gavin E. Arteel. "Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 294, no. 5 (2008): G1227—G1234. http://dx.doi.org/10.1152/ajpgi.00050.2008.

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It is well known that ethanol preexposure sensitizes the liver to LPS hepatotoxicity. The mechanisms by which ethanol enhances LPS-induced liver injury are not completely elucidated but are known to involve an enhanced inflammatory response. Ethanol exposure also increases the metabolic rate of the liver, and this effect of ethanol on liver is mediated, at least in part, by the sympathetic hormone, epinephrine. However, whether or not the sympathetic nervous system also contributes to the sensitizing effect of ethanol preexposure on LPS-induced liver damage has not been determined. The purpose

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Moulin, Frederic, Bryan L. Copple, Patricia E. Ganey, and Robert A. Roth. "Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure." American Journal of Physiology-Gastrointestinal and Liver Physiology 281, no. 6 (2001): G1423—G1431. http://dx.doi.org/10.1152/ajpgi.2001.281.6.g1423.

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Bacterial endotoxin [lipopolysaccharide (LPS)] causes liver injury in vivo that is dependent on platelets, neutrophils [polymorphonuclear leukocytes (PMNs)], and several inflammatory mediators, including thrombin. We tested the hypothesis that thrombin contributes to LPS-induced hepatocellular injury through direct interactions with platelets and/or PMNs in vitro. Perfusion of isolated livers from LPS-treated rats with buffer containing thrombin resulted in a significant increase in alanine aminotransferase (ALT) activity in the perfusion medium, indicating hepatocellular damage. This effect w

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Fogel, W. A., W. Andrzejewski, and C. Maslinski. "Liver damage, voluntary alcohol intake and brain histamine." Agents and Actions 33, no. 1-2 (1991): 150–53. http://dx.doi.org/10.1007/bf01993152.

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Mnatsakanyan, Marina G., Aleksandr P. Pogromov, Aleksei S. Lishuta, et al. "Liver and COVID-19: possible mechanisms of damage." Terapevticheskii arkhiv 93, no. 4 (2021): 427–30. http://dx.doi.org/10.26442/00403660.2021.04.200733.

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The global epidemic of a new coronavirus infection caused by SARS-CoV-2 is a major threat to human health. In the clinical picture, along with acute respiratory distress syndrome, liver lesions are also noted. The following mechanisms are currently being considered: direct damaging effects of SARS-CoV-2, immuno-mediated inflammation, hypoxia, drug exposure, and reactivation of pre-existing liver disease. We studied 150 patients with COVID-pneumonia who are under inpatient treatment at the University Clinical Hospital No. 1 of Sechenov First Moscow State Medical University. Of these, the presen

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Han, Aram, Chang-Yul Keum, Chae-Rim Yoon, et al. "Safety of Herbal Medicines on Liver Function in Functional Dyspepsia Patients: A Single-Center Retrospective Study." Journal of Internal Korean Medicine 44, no. 4 (2023): 635–44. http://dx.doi.org/10.22246/jikm.2023.44.4.635.

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Objectives: This study analyzed laboratory serum data results before and after patients took herbal medicine to confirm the clinical safety of herbal medicine. In addition, in the event of liver damage, the case was analyzed to confirm the characteristics of liver damage and the possibility of liver damage caused by herbal medicine.Methods: A retrospective chart review of the effects of herbal medicine on liver function in patients diagnosed with functional dyspepsia was conducted. The electronic medical records of 128 patients in a single hospital were reviewed.Results: The statistical analys

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Min, David I., Peter A. Burke, W. David Lewis, and Roger L. Jenkins. "Acute Hepatic Failure Associated with Oral Minocycline: A Case Report." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 12, no. 1 (1992): 68–71. http://dx.doi.org/10.1002/j.1875-9114.1992.tb02674.x.

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A 39‐year‐old woman was evaluated for possible liver transplantation due to rapidly developing hepatic failure 4 weeks after initiation of oral minocycline 100 mg twice a day for the treatment of acne. The patient developed a maculopapular rash, malaise, fever, nausea, and vomiting 2 weeks prior to admission to the hospital. On admission, her symptoms rapidly progressed to liver failure characterized by rapidly rising liver enzyme levels, worsening encephalopathy, and coagulopathy. Viral hepatitis serologies and blood cultures were all negative. After intensive supportive care for 2 weeks, the

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Ibrahim, Taisir K., and Zainab Hasan Majeed. "Medical Implications of Gum Arabic." South Asian Research Journal of Biology and Applied Biosciences 7, no. 03 (2025): 203–8. https://doi.org/10.36346/sarjbab.2025.v07i03.007.

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When conventional medical interventions fail to adequately address chronic illnesses, numerous individuals resort to alternative remedies. Included among these treatments are herbal medications, which may have a role in the prevalent and popular use of nutritional supplement-based therapies. This review sought to examine the description and classification of the gum arabic plant, its chemical makeup, its economic and medicinal significance, and its impact on the kidneys, liver, and diabetes. Gum arabic comprises several active constituents and offers multiple economic and medicinal advantages,

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Kim, Kye Y., Wayne Hwang, and Rajesh Narendran. "Acute Liver Damage Possibly Related to Sertraline and Venlafaxine Ingestion." Annals of Pharmacotherapy 33, no. 3 (1999): 381–82. http://dx.doi.org/10.1345/aph.18155.

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Spogis, Jakob, Florian Hagen, Wolfgang M. Thaiss, et al. "Sonographic findings in coronavirus disease-19 associated liver damage." PLOS ONE 16, no. 2 (2021): e0244781. http://dx.doi.org/10.1371/journal.pone.0244781.

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Purpose This study was conducted to evaluate the role of liver sonography in patients with coronavirus disease 2019 (COVID-19) and elevated liver enzymes. Materials and methods In this retrospective study, patients tested positive for SARS-CoV-2 in our emergency ward between January 01 and April 24, 2020 and elevated liver enzymes were included (Cohort 1). Additionally, the local radiology information system was screened for sonographies in COVID-19 patients at the intensive care unit in the same period (Cohort 2). Liver sonographies and histologic specimen were reviewed and suspicious finding

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Ghobadi Pour, Mozhgan, Naser Mirazi, Hojjatollah Alaei, Shirin Moradkhani, Ziba Rajaei, and Alireza Monsef Esfahani. "Effects of lactulose and silymarin on liver enzymes in cirrhotic rats." Canadian Journal of Physiology and Pharmacology 95, no. 5 (2017): 522–29. http://dx.doi.org/10.1139/cjpp-2016-0454.

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Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those

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Farzana, Taposhi, Pijush Karmakar, Jakia Haque, Md Farhan Joha, and Eshrat Jahan Eami. "Study Of Serum Triglyceride And Ldl-cholesterol Among Patients Suffereing From Liver Cirrhosis And Its Relation With Severity of The Disease." Central Medical College Journal 5, no. 1 (2022): 25–29. http://dx.doi.org/10.3329/cemecj.v5i1.60201.

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Background: Cirrhosis is characterized by abnormal structure and function of the liver. Liver synthesizes the various lipoproteins involved in transporting cholesterol and lipids throughout the body. This makes liver an important site for lipid metabolism as well as its transport. Thus liver cirrhosis is associated with lipid abnormalities and the amount of decrement is expected to be significantly correlated with increasing severity of liver damage. Aims and objectives: To determine serum TG and LDL-C in patients with cirrhosis and study their relationship to the severity of cirrhosis.&

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Gabrielli, Maurizio, Laura Franza, Alessandra Esperide, Irene Gasparrini, Antonio Gasbarrini, and Francesco Franceschi. "Liver Injury in Patients Hospitalized for COVID-19: Possible Role of Therapy." Vaccines 10, no. 2 (2022): 192. http://dx.doi.org/10.3390/vaccines10020192.

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Patients with COVID-19 show a high prevalence of liver injury. The pattern of this liver damage is still not fully understood. Different etiopathogenetic factors may concur; from a direct cytopathic effect, once the virus binds to the ACE-2 receptors, to the immune-mediated collateral damage, due to cytokine storm. The presence of pre-existing chronic liver disease is a contributing factor for acute organ damage during SARS-CoV2 infection. Last but not least, treatments probably play a role, also, in determining hepatotoxicity: many of the drugs we have used or are still using to treat COVID-1

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Aleryani, S., A. Kabakibi, J. Cluette-Brown, and M. Laposata. "Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury." Clinical Chemistry 42, no. 1 (1996): 24–27. http://dx.doi.org/10.1093/clinchem/42.1.24.

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Abstract Fatty acid ethyl esters (FAEE), esterification products of ethanol and fatty acids, have been implicated as mediators of ethanol-induced organ damage. Because cytosolic enzymes such as aspartate aminotransferase, lipase, and amylase appear in the blood after liver or pancreatic damage, we hypothesized that FAEE synthase, which is both cytosolic and membrane bound, is also released into the blood of patients with liver or pancreatic disease. We used a method involving thin-layer chromatography coupled with gas chromatography-mass spectrometry to reliably identify and quantify FAEE. In

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