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Sharma, Avinash, Olusegun Isaac Alatise, Kelli O'Connell, Samson Gbenga Ogunleye, Adewale Abdulwasiu Aderounmu, Marquerite L. Samson, Funmilola Wuraola, Olalekan Olasehinde, T. Peter Kingham, and Mengmeng Du. "Healthcare utilisation, cancer screening and potential barriers to accessing cancer care in rural South West Nigeria: a cross-sectional study." BMJ Open 11, no. 7 (July 2021): e040352. http://dx.doi.org/10.1136/bmjopen-2020-040352.
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Background/aimsCancer burden is predicted to double by 2030 in sub-Saharan Africa; access to healthcare services for cancer management is a priority in the region. In Nigeria, National Cancer Control Plan aims to ensure >50% cancer screening of eligible populations by 2022 for all Nigerians. We describe healthcare utilisation, cancer screening activities and potential barriers to accessing cancer care within an understudied rural community-based adult population in South West Nigeria.MethodsIn April 2018, we conducted a cross-sectional study of community-based adults (>18 years) ~130 km east of Ibadan, 250 km from Lagos in Osun State, South West Nigeria. Participants completed a face-to-face survey in local dialect. We used a questionnaire to assess demographics, health status, income, medical expenditures, doctor visits and cancer screening history.ResultsWe enrolled 346 individuals: with median age of 52 years and 75% women. Of the entire cohort, 4% had medical insurance. 46% reported a major medical cost in the last year. Cancer screening activities were infrequent in eligible participants: 1.5% reported having had cervical cancer screening, 3.3% mammogram and 5% colonoscopy screening. Cancer screening assessment was less frequent in those with less income and lower education levels. Using a multivariable logistic regression model including personal income, insurance status and education, higher personal income was associated with more cancer screening activity (OR 2.7, 95% CI 1.3 to 5.7, p<0.01). Despite this, most individuals had contact with a primary healthcare doctor (52% in the last year), and over 70% access to radio and TV suggesting the opportunity to expand community-based screening interventions and awareness exists.ConclusionsDespite national increases in cancer cases, we highlight a deficiency in cancer screening and universal healthcare coverage within a community-based adult Nigerian population. Subject to availability of governmental resources, increasing financial risk protection, awareness and targeted resource allocation may help expand access in Nigeria.
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Olowokere, Idowu Emmanuel, and Olumuyiwa Adebola Roberts. "Male workers’ influence on partners uptake of pap smear screening in a teaching hospital in Nigeria." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 5606. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5606.
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5606 Background: Cervical cancer remains a major global health issue still claiming the lives of African women despite the availability of screening facilities. Male involvement has paid off in enhancing uptake of contraception in Africa as reported by several empirical studies. It may be worthwhile in encouraging women uptake of the screening services. This formed the basis for this study. Methods: The study adopted a cross sectional descriptive survey that involved 350 respondents. Their involvement was assessed using a structured questionnaire with cronbach reliability coefficient of 0.78. The study was analyzed using SPSS version 16 by computing the frequency, means and standard deviations. Chi-square was employed to test the significance of associations at p < 0.05. Results: The results showed that all (n = 350) male medical staff of the hospital were aware about cervical cancer and pap smear screening test for premalignant lesions of the cervix compared to 90% and 77% observed in paramedics and non-medical groups respectively. At least, an episode of Pap smear screening test had been done by the partners of 52.4% of the medical staff; while only 30.2% and 13% of the partners of paramedics and non-medical workers respectively had undergone the test. Among those whose partners had participated in screening; 78.9% (n = 95) of the men initiated the screening. Eighty two percent (82%, n = 95) paid for their wives’ transportation while 78.9% (n = 95) have at least once followed their partners to the screening centre. Chi square result showed that men with higher level of education are likely to support their partners to participate in screening for cervical cancer (p < 0.005). There was no significant association between religion and male support for Pap smear uptake (p < 0.407). Conclusions: The study showed that the medical male workers were more involved in facilitating partners screening for cervical cancer. This may not be unconnected with their knowledge of the consequences of late identification of the disease. The study therefore concluded that knowledge of cervical cancer and its consequences by men will enhance their involvement in encouraging partners to utilize screening facilities.
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Onwuka, C., C. Umezurike, C. E. Hendricks, and K. Eguzo. "Religious Gathering as a Tool for Collaborative Cervical Cancer Prevention: Report From Nigeria." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 137s. http://dx.doi.org/10.1200/jgo.18.75900.
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Background and context: Cervical cancer is the second most common cancer and a leading cause of mortality affecting Nigerian women. There is prevalent ignorance about the disease and reduced access to screening services in Nigeria due to a variety of reasons. Many religious leaders often view cancer as evil, thus perpetuating a culture of fear and denial. Religious events have been used to promote health awareness and access to preventive services in Nigeria, but not usually for cancer screening. A cancer survivor might use a religious event to provide a strong avenue for improving cancer awareness and access to screening. Aim: Report describes a successful collaborative integration of cervical cancer screening into a religious event led by a breast cancer survivor. Strategy/Tactics: The 2018 Annual Women's Gospel Forum at Susanna Homes was used by a cancer survivor to teach women about cervical cancer and early diagnosis. Information was circulated among the Church of Christ fellowship in southern Nigeria. Program/Policy process: A medical team (gynecologist and pathologist) provided free cancer screening to consenting women using Papanicolaou test VIA simultaneously, with Pap preceding VIA. All smears were handled according to standard protocol and the findings were classified using the Bethesda system for reporting Papanicolaou test. Participants were taught about cervical cancer, counseled on screening and follow-up care prior to consent. Data were analyzed using descriptive statistics. Outcomes: Seventy-nine women at the event consented to the screening. The average participant was aged 51 years, but 90.6% (58/64) were above 30 years. Most (92.4%; 73/79) women were negative for squamous intraepithelial lesions (SILs), and six women had a low grade squamous intraepithelial lesion (LSIL). The prevalence of abnormal cervical cytology in this outreach was 7.6% (6/79), and mostly affected women aged 61-60 years. Table 1 describes the Papanicolaou test results. The result of VIA was recorded as positive or negative. What was learned: Participants provided positive feedback regarding integrating cervical cancer screening into a religious event, as it improved access and addressed ignorance. Leadership by a cancer survivor helped demystify the disease and encouraged women to be screened. Having a pathologist on site improved slides quality and reporting turn-around time. Project shows that collaboration between clinicians and religious leaders can improve cancer prevention. More physicians should be trained to provide these services and collaborate with community/religious organizations to provide screening outside of the clinical setting.[Table: see text]
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Awosan, Kehinde Joseph, Edzu Usman Yunusa, Ngwobia Peter Agwu, and Suleiman Taofiq. "Knowledge of prostate cancer and screening practices among men in Sokoto, Nigeria." Asian Journal of Medical Sciences 9, no. 6 (October 29, 2018): 51–56. http://dx.doi.org/10.3126/ajms.v9i6.20751.
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Background: Halting the rising burden of prostate cancer across the globe has become a major public health challenge with the absence of intellectual consensus on the effective strategies for its prevention. However, knowledge of the disease and uptake of prostate cancer screening remain indispensable in mitigating the dire consequences of the prevalent late presentation of patients with the disease in sub-Saharan Africa.Aims and Objectives: This study was designed with an aim to assess prostate cancer knowledge and screening practices among men in Sokoto, Nigeria.Materials and Methods: A descriptive cross-sectional study was conducted among 300 participants (selected by systematic sampling technique) attending the medical and surgical outpatient clinics of UDUTH, Sokoto, Nigeria. Data were collected with a pretested, structured questionnaire and analyzed using IBM SPSS version 20 computer software.Results: The mean age of the respondents was 53.13 ± 7.92 years. Only 15 (5.0%) and 4 (1.3%) of the 300 respondents were aware of prostate cancer and prostate cancer screening respectively. Most of the respondents (95.0%) had poor knowledge of prostate cancer, and none of them have ever had a prostate cancer screening test done, with the most commonly cited reason being lack of awareness (98.6%).Conclusion: This study showed poor knowledge of prostate cancer and zero uptake of prostate cancer screening among the participants. These findings highlight the need for government and healthcare providers to sensitize the public on prostate cancer and its prevention, in addition to facilitating unrestricted access of those at risk to prostate cancer screening services.Asian Journal of Medical Sciences Vol.9(6) 2018 51-56
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Oyekale, Rahmat A., O. Abimbola Oluwatosin, and Olaide B. Edet. "Predictors of uptake of cervical cancer screening among nurses in Ogbomoso, Nigeria." African Journal of Midwifery and Women's Health 15, no. 1 (January 2, 2021): 1–9. http://dx.doi.org/10.12968/ajmw.2019.0039.
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Background/Aims More than one million women are currently living with cervical cancer. Approximately 311 000 deaths were attributed to the disease in 2018, with the majority occurring in low- and middle-income countries, like Nigeria. Cervical cancer screening has been consistently shown to be effective in reducing the occurrence of new cases of cervical cancer and mortality related to the disease. This study aimed to determine the predictors of cervical cancer screening among nurses in Ogbomoso, Oyo State. Methods This was a descriptive cross-sectional study, which used a structured pretested questionnaire to collect data from 230 nurses randomly selected from two settings in Ogbomoso, Nigeria. Data were analysed using descriptive statistics, Chi-Square and logistic regression. Results All participants had heard of cervical cancer and its screening measures. More than half of the respondents (68.7%) had never submitted for screening. The respondents reported factors such as lack of facilities (77.0%), financial status (76.5%), lack of awareness (75.7%), inconvenient screening time (75.7%) and level of education (71.7%) as influencers of use of cervical cancer screening. Logistic regression analysis showed marital status was significantly related to cervical cancer screening usage (P=0.047). Conclusions Good knowledge of nurses on cervical cancer screening does not translate to uptake of screening services. It is recommended that cervical and other cancer screening services should be included in the pre-employment medical examination of nurses to compel usage of screening services.
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Adeniyi, B. O., O. S. Ilesanmi, A. M. Adebayo, A. O. Kareem, O. A. Junaid, A. O. Adeniji, and G. E. Erhabor. "Assessment of risk of obstructive sleep apnoea syndrome among patients attending a medical outpatient clinic in a tertiary health facility in South-West Nigeria." South African Respiratory Journal 21, no. 1 (October 21, 2015): 3. http://dx.doi.org/10.7196/sarj.7740.
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<p><strong>Background</strong>. Obstructive sleep apnoea syndrome (OSAS) is associated with increased morbidity and mortality. However, there are few studies from Nigeria that have evaluated the prevalence of OSAS in medical outpatient clinics.</p><p><strong>Objective</strong>. To determine the degree of the risk of OSAS among patients attending the medical outpatient clinic of the Federal Medical Centre, Owo, South-West Nigeria.</p><p><strong>Methods</strong>. A cross-sectional survey was conducted among 208 medical outpatients using the Berlin questionnaire and the Epworth sleepiness scale (ESS).</p><p><strong>Results</strong>. The mean (standard deviation) age of participants was 53.8 (16.5) years, 110 (52.9%) were female, and 73.1% of participants had a high likelihood of sleep-disordered breathing (HSDB). Subjects with a high body mass index (BMI) were more likely to have sleep -disordered breathing when compared with those with a normal BMI (26 (96.3%) v. 7 (29.2%), p<0.001). The respondents with multiple primary morbidities were about 24 times more likely to have HSDB compared with respondents with a single morbidity (p=0.009). The odds of having HSDB was 16 times greater in those with hypertension compared with patients with asthma (odds ratio 16, 95% confidence interval 3 - 83, p=0.001). The Berlin questionnaire and the ESS were useful screening tools in the Nigerian setting.</p><p><strong>Conclusion.</strong> In resource-poor settings in Africa, where there is an emphasis on screening and treating diseases of poverty, patients with medical conditions such as high BMI and hypertension should be screened for OSAS.</p>
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Chinawa, A. T., J. M. Chinawa, E. Aniwada, Oge Amadi, A. C. Ndukuba, and S. N. Uwaezuoke. "Spectrum of Anxiety Disorders Among Medical Students in a Nigerian Medical School: A Cross-Sectional Study With Standardized Screening Tools." Journal of Educational and Developmental Psychology 8, no. 2 (September 3, 2018): 132. http://dx.doi.org/10.5539/jedp.v8n2p132.
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BACKGROUND: Anxiety disorders among medical students constitute a global problem, and also reflect the mental state of the general population. There is paucity of data on the spectrum of such disorders among medical students in Nigeria.AIM: The study aims to determine the prevalence of anxiety disorders among medical students, and the effect of socio-demographic characteristics.METHODS: A total of 217 medical students from the second to the final years of study at Enugu State University of Science and Technology in south-east Nigeria were enrolled by simple random sampling. Five pretested, self- administered standardized questionnaires were used as screening tools for anxiety disorders. Data were analyzed using the Statistical Package for Social Sciences program (SPSS version 20). A p-value less than 0.05 was taken as statistically significant.RESULTS: Thirty one (14.3%) of the enrolled medical students fulfilled the screening criteria for anxiety disorders. Specifically, generalized anxiety disorder (GAD) was significantly related to gender (p =0.017) and the year of study (p =0.017). Post-traumatic stress disorder (PTSD) was significantly related to the year of study (p =0.037), and social anxiety disorder (SAD) to the year of study (p =0.003) and gender (p =0.04). Similarly, panic disorder was significantly related to the year of study (p =0.025) while specific phobia was significantly associated with marital status (p =0.003), parental monthly income (p =0.022) and student’s monthly allowance (p =0.002). Finally, obsessive-compulsive disorder was significantly related to marital status (p =0.034) and year of study (p =0.028).CONCLUSION: Medical students in Nigeria are prone to a spectrum of anxiety disorders. This susceptibility is influenced by socio-demographic characteristics.
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Osuchukwu, Ngozi P., and Ngozi B. Ukachi. "Health information services: Engaging women in cervical cancer screening awareness in Nigeria." IFLA Journal 45, no. 3 (July 16, 2019): 224–32. http://dx.doi.org/10.1177/0340035219861400.
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Around the world, a woman dies of cervical cancer every two minutes. In Nigeria, it is the second leading cause of cancer deaths, which could be avoided with proper access to health information. This mixed methods study, which employs a questionnaire, interviews, observations and discussion, examined women’s awareness on cervical cancer, screening status, sources, attitude and willingness, factors deterring them from being screened, and lessons learnt. Screening was done using visual inspection with acetic acid (VIA). The study involved two librarians, two medical doctors, a pharmacist and a laboratory scientist: 90 women participated in the cervical screening exercise in non-standard settings – an e-library and a cathedral. It was discovered that 90% of the women had never been screened. Thus, if the women are not sensitized on cervical cancer they may never go for screening and more casualties will be recorded. The paper concludes with recommendations and a call to action for all, especially librarians.
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Adebamowo, Clement, Maryam Almujtaba, Zahra Modibbo, Olayinka Olaniyan, and William Blattner. "F2 Quality Assurance of Nurse Provider Led Cervical Cancer Screening in Nigeria." JAIDS Journal of Acquired Immune Deficiency Syndromes 59 (April 2012): 85–86. http://dx.doi.org/10.1097/01.qai.0000413815.27179.9c.
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Egwuchim, K., and A. Nzelu. "Establishment of Structured Preventive Mobile Cancer Care in Nigeria: A Success Story." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 188s. http://dx.doi.org/10.1200/jgo.18.32600.
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Background and context: Mass medical mission is a nonprofit, public health charity aimed at complementing the effort of government in improving the health indices of Nigerians. Its core initiative is the National Cancer Prevention Program (NCPP), a foremost effort toward national cancer control in Nigeria. In 2007, NCPP spearheaded community-based mass cervical cancer screening in Nigeria, initially known as National Cervical Cancer Prevention Program (NCCPP). This effort has contributed to a 15% reduction of cervical cancer mortality in Nigeria, from 9659 deaths to 8240 deaths, between 2008 and 2012 (GLOBOCAN data). The improvement in cervical cancer survivorship in Nigeria was proof positive that winning the fight against cancer was possible if the effort could be scaled up. Consequently, mass medical mission escalated its advocacy drive, which was tagged the Big War Against Cancer in Nigeria. Aim: The short-term goal was to raise funds toward the provision one Mobile Cancer Centres (MCC) for each state and a Comprehensive Cancer Centre for each of the six geopolitical zones in the long-term. Strategy/Tactics: Mass medical mission initiated the establishment of a fundraising platform known as the Committee Encouraging Corporate Philanthropy (CECP-Nigeria). A private sector led initiative to promote concerted and synergistic philanthropy for the common good through public-social-private partnership. The President of Nigeria is the grand patron while the Vice President, the National Patron. Returns: Through this effort, four of the pilot set of MCC (known as PinkCruise) are now in Nigeria, one of which was donated by the Lagos State Governor. The fixed centers from which the PinkCruise operate have also been set up in four selected cities representing the four old regions of Nigeria. These mobile units are unique as they are multifunctional with state-of-the-art facilities for screening, follow-up and treatment (including mammography, endoscopy, colonoscopy, colposcopy, cryotherapy, laboratory, vaccination and surgeries for precancer and early cancer). The PinkCruise have been deployed to carry out systematic mobile health outreaches, known as Mission PinkCruise, which also have an eye-care aspect known as Mission PinkVISSION. PinkVISSION is also an initiative of mass medical mission (mmm), aimed at achieving the goals of “Vision 2020: The Right to Sight”, by incorporating preventive eye care into cancer prevention and general health promotion. The acronym, VISSION, stands for Voluntary Integrated Sight Saving Initiative Of Nigeria. Both Mission PinkCruise and Mission PinkVISSION are free of charge to the hosts and the beneficiaries. What was learned: The synergy between PinkVISSION and PinkCruise results in improved uptake, impact and cost effectiveness of both the cancer campaign and the eye campaign.
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Ndubueze, Pleasant C., Eunice O. Igumbor, Otovwe Agofure, Anthonia C. Okwelum, Prince C. Ozuem, and Ezekiel U. Nwose. "Prospects of diabetes registry and standard care at primary health facilities in Nigeria: experiential note." International Journal Of Community Medicine And Public Health 7, no. 1 (December 25, 2019): 144. http://dx.doi.org/10.18203/2394-6040.ijcmph20195844.
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Background: As part of the series to advance diabetes register, the aim of this piece of the project was to evaluate the development of a diabetes register at primary healthcare (PHC) level in Delta State Nigeria. This is with a view to determine the PHC capacity for diabetes services.Methods: This clinical observational study was carried out in Novena University health centre in Ukwani Local Government Area and Ogume primary health centre in Ndokwa West Local Government Area, Delta State. A community-based screening was carried out in three communities of Amai, Ezionum and Ogume in July to September 2018, after which a diabetes registers were developed in Novena University health and Ogume primary health centres. Cases of probable diabetes were identified during screening and entered into the diabetes register being developed, which formed the sampled population (n=42). The data were analysed using Microsoft Excel Data Analysis ToolPak 2010.Results: Glucometer, stethoscope and sphygmomanometer were the most available equipment at the two facilities. Medical records of patients were incomplete with 81% missing home addresses and 62% did not have phone numbers. Others records such as date of entry, height, weight and type of diabetes were not recorded. The study also showed 35% prevalence of hypertension in diabetes cases.Conclusions: There is capacity to run diabetes screening and service clinic at the primary healthcare levels, but the limitation was incomplete patient information in the medical records. In development of a diabetes registry at the primary healthcare level, the study recommends comprehensive patients’ documentation during screening and routine medical check-up.
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Lasebikan, A., A. Nnamani, N. Iloanusi, I. Okoye, C. Okwuosa, L. Ezeilo, and I. Mba. "BWS Effort in Cancer Screening in Rural Communities." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 146s. http://dx.doi.org/10.1200/jgo.18.65400.
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Background and context: Nigeria, being the most populous African country has the highest cancer burden. Most of the population reside in rural areas where there are no functional health centers. Life in these communities is marked by profound ignorance, superstition and stigma, concerning cancers. There is no cancer control plan in place in the country. Aim: BWS aims at increasing awareness of the need for prevention and early detection of cancers. Strategy/Tactics: Three-pronged approach of education, screening and vaccination, with navigation where required. Monthly education and cancer screening in rural communities. Provision of a navigation system of medical follow-up for patients with a positive screening result; establishing treatment and support care for patients and recruiting and training volunteers and local advocates for cancer awareness campaigns. Program/Policy process: Monthly education/enlightenment activities in various rural communities in southeast Nigeria. Dissemination of information on screening activities is done via church and other community groups; town criers, WhatsApp, radio and banners at strategic locations. Outcomes: A total of 1990 participants (1388 females and 602 males) were screened from January 2016 to December 2017. 1342 women had CBE, 96 were referred for mammography. 105 out 1041 females who had VIA with colposcopy were positive and 26 of them had cryotherapy. 426 girls and young women (9-26 years) received HPV vaccination. 12 out of 204 men who had PSA tests were positive and referred to urologists. Since the launch of project Rid Nigeria of Late Cancer Detection in 2016, BWS has acquired a physical infrastructure for daily screening and continued her monthly rural screening services. What was learned: Women need to take permission from their husbands to even get screened, therefore involvement of traditional rulers, local government chairmen, opinion molders, leaders of faith-based organizations, and local cancer advocates from the community, is helping to increase awareness and reduce stigmatization. Taking the screening to the community is helping combat “late presentation syndrome”. However, financing rural awareness and screening is quite a challenge without financial support.
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Anene-Okeke, Chigozie Gloria, Deborah O. Aluh, and Uzoamaka Henrietta Okorie. "Knowledge, Attitudes and Practice of Cervical Cancer Prevention among Student Health Professionals in Nigeria." Asian Pacific Journal of Cancer Care 4, no. 4 (August 11, 2019): 125–30. http://dx.doi.org/10.31557/apjcc.2019.4.4.125-130.
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Background: Cervical cancer is the second most commonly diagnosed gynecological cancer affecting women worldwide. It is a preventable disease but still remains a leading cause of cancer deaths in developing countries like Nigeria despite the availability of preventive strategies. Undergraduate pharmacy and medical students are future health care providers who can help raise awareness and improve the knowledge of the public towards cervical cancer, its screening, prevention and treatment. The study sought to assess the knowledge, attitudes and practice of cervical cancer screening and prevention.
Materials and methods: This is a cross sectional survey using questionnaire conducted in the University of Nigeria and Nnamdi Azikiwe University both in South-eastern Nigeria. Participants were conveniently sampled and the self-administered questionnaire was given to 335 consenting female pharmacy and medicine undergraduate students.
Results: 335 out of the 350 undergraduate students approached responded (95.7 % response rate). The result of the study shows that the students generally had a good level of awareness of cervical cancer. The students surveyed had a mean knowledge score of 75.9062±20.265. More than a third (36.1%, n = 214) of the students had a negative attitude towards cervical cancer. Only about one in eight students reported to have had a pap smear (12.54%, n = 42).
Conclusion: The students generally had a good awareness and knowledge of cervical cancer which was not translated into practice. There is a need to include public health principles into the curriculum of Pharmacy and Medical schools in Nigeria since they are future health advisors.
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Hardick, Justin, Trevor A. Crowell, Kara Lombardi, Akindiran Akintunde, Sunday Odeyemi, Andrew Ivo, George Eluwa, et al. "Molecular screening for Neisseria gonorrhoeae antimicrobial resistance markers in Nigerian men who have sex with men and transgender women." International Journal of STD & AIDS 29, no. 13 (July 4, 2018): 1273–81. http://dx.doi.org/10.1177/0956462418780050.
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Antimicrobial-resistant Neisseria gonorrhoeae (NG) is a global public health issue that threatens effectiveness of current treatments of NG. Increased use of nucleic acid amplification tests (NAATs) in lieu of cultures makes obtaining clinical isolates for susceptibility testing difficult and samples collected in commercial transport buffer for NAATs do not preserve viable organism, while molecular methods of assessing antibiotic susceptibility do not require viable organism. We evaluated 243 NG-positive samples in Aptima transport media including urine, oral, and rectal swabs from Nigerian men who have sex with men for markers to penicillinase-producing NG, ciprofloxacin ( GyrA and ParC mutations), and extended spectrum cephalosporins (ESCs, PenA mosaic [allele X], PonA, mtrR, PorB mutations) by real-time PCR. NG DNA was recovered in 75% (183/243) of samples. Of these, 93% (171/183) were positive for at least one resistance marker. We observed a prevalence of dual resistance markers to penicillin and ciprofloxacin at 46.2% (79/171). Six percent of samples (10/171) tested positive for the PenA mosaic (allele X) ESC marker. These data indicate that antibiotic-resistant NG is common in Nigeria. Laboratory and clinical capacity building in Nigeria should include development of methods to culture NG and determine antimicrobial susceptibility.
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Sanda, K. A., U. K. Sandabe, F. A. Sanda, M. B. Tijjani, Y. B. Majama, and B. G. Gambo. "Phytochemical Screening of the Aqueous Root Extract of Leptadenia hastata (Asclepiadaceae) in Maiduguri, Northern Nigeria." Asian Journal of Biochemistry 8, no. 1 (December 15, 2012): 33–35. http://dx.doi.org/10.3923/ajb.2013.33.35.
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Komolafe, M. A., O. Ogunlade, and E. O. Komolafe. "Stroke mortality in a teaching hospital in South Western Nigeria." Tropical Doctor 37, no. 3 (July 1, 2007): 186–88. http://dx.doi.org/10.1258/004947507781524557.
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Stroke, a major cause of morbidity and mortality, is on the increase and with increasing mortality. Our retrospective review of all stroke admissions from 1990-2000 show that cerebrovascular disease accounted for 3.6% (293/8144) of all medical admissions; it has a case fatality rate of 45% with the majority (61%) occurring in the first week; the mean age of stroke deaths was 62 years (standard deviation-13); and severe as well as uncontrolled hypertension is the most important risk factor. Community-based programmes aimed at early detection and treatment of hypertension, in addition to screening for those with high risk factors, should be put in place.
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Anyaeze, Chineme M., Ndubuisi Eke, Kenneth K. Anyanwu, and Stephen E. Enendu. "Rural Medical and Surgical Outreach Mission: Experience of International College of Surgeons (The Nigerian National Section)." International Surgery 103, no. 1-2 (April 1, 2019): 2–8. http://dx.doi.org/10.9738/intsurg-d-17-00131.1.
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Nigeria lacks an equitable healthcare system. Low earnings characterize the income in rural areas where 55% of Nigerians who cannot afford basic medical care live. An organized rural medical and surgical outreach program can augment the formal healthcare system. Objective: To key into the International College of Surgeons Humanitarian Surgery Program by providing surgical specialists through collaboration to a sustainable free medical and surgical program. Methodology: International College of Surgeons (The Nigerian National Section), Imo State zone collaborated with Mbano National Assembly Inc. USA to do a Free Medical and Rural Surgical Outreach Mission at Mbano Joint Hospital March 14–18, 2016. Personnel to cover the clinical and nonclinical areas were recruited by the zonal branch of International College of Surgeons. Mbano National Assembly funded the project with $22,963.83. Results: Some 5028 patients attended. Of these, 2900 received attention, 800 medical, 512 surgical and urology, 262 obstetrics and gynecology, 270 pediatrics, 800 ophthalmic, and 500 received counseling, while 1500 received health education and 25, physiotherapy. Screening for prostate cancer was done for 146, 200 for human immunodeficiency virus and 110 for Hepatitis B virus. Surgical procedures on 88 patients, 1193 outpatient pharmacy dispensing, and 31 in-patients were recorded. Conclusion: Collaboration between sections of International College of Surgeons and non-governmental organizations already involved in rural free medical missions is feasible.
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Abiodun, O. A. "A Validity Study of the Hospital Anxiety and Depression Scale in General Hospital Units and a Community Sample in Nigeria." British Journal of Psychiatry 165, no. 5 (November 1994): 669–72. http://dx.doi.org/10.1192/bjp.165.5.669.
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BackgroundThe utility of the Hospital Anxiety and Depression Scale (HADS) as a screening instrument for anxiety and depressive disorders in non-psychiatric units (medical & surgical wards; gynaecology & antenatal clinics of a teaching hospital) and a community sample in Nigeria was investigated.MethodA two-stage screening procedure was employed. This involved the use of GHQ–12/GHQ–30 and HADS against the criteria of a standardised (PSE schedule) psychiatric interview, with psychiatric diagnosis assigned in accordance with ICD–9 criteria.ResultsSensitivity for the anxiety sub-scale ranged from 85.0% in the medical and surgical wards to 92.9% in the ante-natal clinic, while sensitivity for the depression sub-scale ranged from 89.5% in the community sample to 92.1% in the gynaecology clinic. Specificity for the anxiety sub-scale ranged from 86.5% in the gynaecology clinic to 90.6% in the community sample, while specificity for the depression sub-scale ranged from 86.6% in the medical and surgical wards to 91.1 % in the ante-natal clinic and community sample. Misclassification rates ranged from 9.9% in the community sample to 13.2% in the medical and surgical wards. Relative Operating Characteristic (ROC) analyses showed the HADS and the GHQ–12 to be quite similar in ability to discriminate between cases (anxiety and depression) and non-cases.ConclusionsThe HADS is valid for use as a screening instrument in non-psychiatric units and although initially developed for use in hospital settings, it could be usefully employed in community settings of developing countries to screen for mental morbidity.
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Ejike Chukwuani, Anselm. "An Audit of Routine Chest X-ray Done During Pre-employment Medical Screening in South-Western Nigeria." Central African Journal of Public Health 3, no. 4 (2017): 51. http://dx.doi.org/10.11648/j.cajph.20170304.13.
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Ojewole, OE, U. Abubakar, and AO Olowu. "Haematological parameters of apparently healthy neonates at the Federal Medical Centre Bida, North Central Nigeria." Annals of Health Research 6, no. 3 (August 22, 2020): 276–86. http://dx.doi.org/10.30442/ahr.0603-04-90.
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Background: Haematological parameters are used as screening tools for patient’s care and treatment. Objective: To determine the haematological parameters of apparently healthy term Nigerian babies and generate normative data. Methods: This was a descriptive, longitudinal study of consecutively recruited babies. The haematological parameters were determined using venous blood samples drawn at delivery and on the 14th day of life using a haematology auto-analyser. Results: Of the 309 babies recruited on the first day of life, 160 (51.8%) were males while 149 (48.2%) were females. Two hundred and seventy-nine (90.3%) were delivered vaginally. Most (75%) of the neonates were of Nupe origin. The mean haematocrit, haemoglobin concentration, Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), Red Blood Cell and reticulocyte count on Day 1 were 48.8±8.0%, 15.0±2.6g/dl, 104.1±8.8fl, 31.9±3.3pg, 30.7±1.7g/dl, 4.7±0.9 (×109/l) and 2.0±1.4% respectively. Corresponding Day 14 values were 41.2±5.2%, 12.8±1.9g/dl, 97.2±9.8fl, 30.3±3.8pg, 31.1±1.7g/dl, 4.5±0.6 (×109/l) and 1.0±0.7% respectively. The mean White Blood Cell (WBC) and platelet counts were 13.3±4.8 (×109/l) and 228.3±81.2 (×109/l) respectively, on the 1st day of life and 10.1±2.4 (×109/l) and 370.1±120.7 (×109/l) respectively on the 14th day. The mean differential WBC counts were 49.4±12.0% for neutrophils and 37.4±11.3% for lymphocytes on the 1st day and 32.4±10.0% and 52.8±9.3% respectively on the 14th day. Conclusion: Neonates from Bida have haematological parameters comparable with previously reported values from other parts of Nigeria.
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Twahir, Majid, Rasaaq Adisa Oyesegun, Joel Yarney, Andrew Gachii, Clement Edusa, Chukwumere Nwogu, Gitangu Mangutha, et al. "Access to care and financial burden for patients with breast cancer in Ghana, Kenya, and Nigeria." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 6562. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.6562.
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6562 Background: Breast cancer is the most frequently diagnosed malignancy and the most common cause of cancer-related death in women in Ghana, Kenya, and Nigeria. We evaluated healthcare resource use and financial burden for patients treated at tertiary cancer centers in these countries. Methods: Records of breast cancer patients treated at the following government/private tertiary centers were included – Ghana: Korle-Bu Teaching Hospital and Sweden Ghana Medical Centre; Kenya: Kenyatta National Hospital and Aga Khan University Hospital; Nigeria: National Hospital Abuja and Lakeshore Cancer Center. Patients presenting within a prespecified 2-year period were followed until death or loss to follow-up. Results: The study included 299 patient records from Ghana, 314 from Kenya, and 249 from Nigeria. The use of common screening modalities (eg, mammogram, breast ultrasound) was < 45% in all 3 countries. Use of core needle biopsy was 76% in Kenya and Nigeria, but only 50% in Ghana. Across the 3 countries, 91-98% of patients completed blood count/chemistry, whereas only 78-88% completed tests for hormone receptor and human epidermal growth factor receptor 2 (HER2). Most patients underwent surgery: mastectomy (64-67%) or breast-conserving Most patients in Ghana and Nigeria (87-93%) paid for their diagnostic tests entirely out of pocket (OOP) compared with 30-32% in Kenya. Similar to diagnostic testing, the proportion of patients paying OOP only for treatments was high: 72-89% in Nigeria, 45-79% in Ghana, and 8-20% in Kenya. Among those receiving HER2-targeted therapy, average number of cycles was 5 for patients paying OOP only vs 14 for patients with some level of insurance coverage. Conclusions: Patients treated in tertiary facilities in sub-Saharan African countries lack access to common imaging modalities and systemic therapies. Most patients in Ghana and Nigeria bore the full cost of their breast cancer care, suggestive of privileged financial status. Access to screening/diagnosis and appropriate care is likely to be substantively lower for the general population.
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Musa, Jonah, Olugbenga Silas, Supriya D. Mehta, Robert L. Murphy, and Lifang Hou. "Use of Appropriate Technology to Improve Cervical Cancer Prevention and Early Detection: Experience in Jos, Nigeria." Journal of Global Oncology 5, Supplement_1 (October 2019): 7. http://dx.doi.org/10.1200/jgo.19.16000.
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PURPOSE In absolute numbers, Nigeria is one of the countries with the highest burden and mortality as a result of invasive cervical cancer (ICC), with more than 53 million women at risk. The coverage for available cervical cancer screening by conventional cytology is less than 9% of the population. Also, the lack of a national human papillomavirus vaccination program and organized cervical cancer screening services could partly be responsible for the more than 14,000 new ICC cases and 8,000 deaths attributable to ICC in Nigeria every year. Furthermore, the prevailing challenges of diagnosis at advanced stages in more than 80% of ICC cases with a paucity of trained oncologists and poor treatment infrastructures often result in high death rates. These problems make the use of appropriate technology to improve screening, early detection, and treatment of precancerous conditions a novel strategy for achieving quality cancer care in our setting. The objective of this study was to discuss our experience with use of available and resource-appropriate technology to improve cervical cancer care and outcomes in Jos, Nigeria. METHODS A critical review of cervical cancer prevention, diagnosis, and treatment facilities and outcomes in Nigeria was done. This background information provided justification for the use of resource-appropriate technology for improving quality of cervical cancer prevention and treatment outcomes in resource-limited settings. We also gleaned from specific experiences of cervical cancer screening, follow-up, and treatment of both precancer and early invasive cervical cancer in Jos, Nigeria. RESULTS The main factors responsible for increasing burden and poor cervical cancer outcomes in Nigeria and other resource-limited settings in sub-Saharan Africa include: HIV infection; lack of organized cervical cancer screening programs, with poor coverage even when opportunistic screening is available; weak health care system; illiteracy; and poor human papillomavirus vaccination coverage. Some of the major challenges in treatment of cervical cancer include: late presentation, with poor treatment infrastructures; paucity of trained gynecologic oncologists, medical oncologists, and other disciplines needed to improve quality of cancer care; and poor access to available prevention and treatment services, with limited/no health insurance coverage. CONCLUSION Resource-limited settings should leverage the widespread availability of mobile phones to improve cervical cancer education and scheduling for screening, follow-up, and treatment of precancerous conditions. Also, the use of radio talks can reach women in remote locations. Adoption and use of novel testing technology, such as self-sample collection for human papillomavirus DNA testing, is also advocated. Our team in Jos, with collaboration with Northwestern University, is also looking ahead through molecular research on how epigenetic and microbiome biomarkers could improve prevention and early detection of precancer and ICC as a strategy for improving outcomes in our population. Also, the utility of low-cost treatment modalities, such as battery-operated thermocoagulation, could improve coverage for treatment of cervical precancer. Finally, resource-limited settings should train general gynecologists with interest in oncology to acquire specific competencies for locoregional surgical control, particularly for early-stage cervical cancer. Given the identified challenges, the judicious use of these resource-appropriate technologies may improve quality of cancer care and outcomes in resource-limited settings.
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Ibisola, Babalola Adeniyi, and Margaret Sherratt. "Annual Screening for Chronic Kidney Disease using Urinary Dipstick to Detect Proteinuria among Elderly Patients with Hypertension and Diabetes Mellitus Attending Agbeke Mercy Medical Clinic, Oluyole Cheshire Home, Ibadan, Nigeria." International Journal of Contemporary Research and Review 9, no. 07 (July 25, 2018): 20497–530. http://dx.doi.org/10.15520/ijcrr/2018/9/07/556.
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Background: Chronic kidney disease (CKD) is a highly prevalent medical condition throughout the world, with worsening indices in the developing countries. The economic burden with renal replacement therapy is something that most developing nations may find difficult to cope with. It is important for those at risk of CKD to be screened and identified early in order to prevent or slow progression to advanced stages. There are different screening methods for CKD, the acceptable minimum is an annual screening with the use of dipstick to detect urinary protein.
Methodology: For the first cycle of the audit, medical records of the elderly hypertensive and diabetic patients attending Agbeke Mercy Medical Clinic were obtained for a retrospective assessment of their annual urinalysis uptake. A ninety percent standard was set for the second audit cycle. This was followed by a three months prospective dipstick (Medi-Test Combi 10® SGL) urinalysis screening, after health talks and a significant subsidization of the screening cost for all the participants were put in place.
Results: The records showed that 37% (32) of the eligible 87 patients had a dipstick urinalysis screening done in the preceding one year. In the three months, 93% (79) were screened for urinary protein with dipstick. 12.6% results were positive for at least 1+ of proteinuria.
Conclusion: Clinical audit is very important in improving clinical practice. It helps to identify areas of practice that may need improvement, as in this case annual screening for CKD with dipstick urinalysis, especially among patients who are at the risk of developing CKD. Despite financial constraints, efforts should be made to make CKD screening a routine in all at-risk patients
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Danfulani, Mohammed, Ahmed Sule Sa'idu, Mohammed Sadisu Ma'aji, and Muhammad Awwal Musa. "Pattern of mammographic findings in Sokoto, Nigeria." Asian Journal of Medical Sciences 5, no. 4 (May 17, 2014): 79–83. http://dx.doi.org/10.3126/ajms.v5i4.9864.
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Background: Radiological examination of the breast is established as an essential part of the modern multidisplinary approach to effective investigation and management of breast diseases. The standard techniques used for breast imaging are screen film X-ray mammography and real time ultrasound. The aim of this study is to document mammographic findings in females seeking medical attention at the Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria. Methods: The study was a descriptive retrospective analysis of the mammographic breast examinations (both screening and diagnostic) seen over a period of one year (February 2012 - January 2013). A total 125 patients were recruited in this study. Relevant parameters extracted from the records included patients age, presenting complain, referring clinic/unit, indications and the reporting radiologist findings (diagnosis). All the data collected were analyzed using a Statistical Package for Social Sciences (SPSS) version 17.0 windows. Results: The age range of the study participants was 18 to 71 years with a mean and standard deviation value of 41.87±10.15. Majority of our patients (44%) were referred from GOPD (General Out Patient Department); followed by SOPD (Surgical Out Patient Department) with 41 patients (32.8%). Other referring clinics included Accident and Emergency (A and E) (3.2%), Staff Clinic (1.6%), Medical outpatient Department (MOPD) 4.0%, Clinic 1 less than 1%. Gynea Clinic (3.2%) and Radiotherapy Unit (1.6%). The commonest indications for these examinations in our patients include Breast Pain (unilateral or bilateral); Breast Lump (unilateral or bilateral), bloody nipple discharge, ?Breast Cancer (left or right), Fibrocystic dysplasia, mastitis among others. The predominant diagnosis observed in our results was BIRADS 1 (normal examination) which constituted 73 (58.4) patients. Conclusion: Most of our patients for diagnostic mammography were found to have Benign breast diseases than breast cancers; suggesting that there is a high diagnostic yield of mammography in the evaluation and management of breast diseases in this environment. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9864 Asian Journal of Medical Sciences 2014 Vol.5(4); 79-83
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Jac-Okereke, Chinwe Cynthia, Chukwunonso Azubuike Jac-Okereke, Ifeoma Regina Ezegwui, and Obiekwe Okoye. "Vision Screening in Infants Attending Immunization Clinics in a Developing Country." Journal of Primary Care & Community Health 11 (January 2020): 215013272090743. http://dx.doi.org/10.1177/2150132720907430.
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Background: Vision screening in infants is an important part of the medical care of children as some eye abnormalities, if not treated in the first few months or years of life, can lead to irreversible vision loss. Objective: The objective of this cross-sectional, descriptive study was to identify ocular anomalies among infants attending immunization clinics in Nigeria and refer promptly and appropriately. Methodology: Infants were screened across 6 immunization clinics. Screening activities included relevant ocular history, vision assessment, external ocular examination, ocular motility, Hirschberg’s test, pupil examination, and the red reflex test. Infants with abnormal findings were referred for comprehensive eye examination. Result: Of the 142 infants who underwent vision screening, 29 were referred. These referrals were either as a result of ocular abnormalities (n = 22) or presence of risk factors from history (n = 7). The prevalence of ocular abnormalities was 15.5% and neonatal conjunctivitis (38%), was the commonest ocular abnormality found. Others were bacterial conjunctivitis (14%), nasolacrimal duct obstruction (14%), strabismus (14%), capillary hemangiomas (10%), iris nevi (5%), and vernal keratoconjunctivitis (5%). Of the 7 infants referred based on history alone, 6 (85.7%) had a history of prematurity. Conclusion: Conjunctivitis, strabismus, congenital nasolacrimal duct obstruction, and capillary hemangioma are some of the prevalent disorders seen in infants at immunization clinics in Nigeria. Babies at risk of retinopathy of prematurity (preterm birth and oxygen therapy) can be identified. Immunization clinics can serve as good points of vision screening for infants in developing countries to facilitate prompt referral and treatment.
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Ofori, Sandra N., and Frances N. Adiukwu. "Screening for Depressive Symptoms among Patients Attending Specialist Medical Outpatient Clinics in a Tertiary Hospital in Southern Nigeria." Psychiatry Journal 2018 (October 18, 2018): 1–6. http://dx.doi.org/10.1155/2018/7603580.
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This study aimed to determine the prevalence of unrecognized depressive symptoms and its associated risk factors among patients with diabetes and/or hypertension attending medical outpatient clinics of a tertiary health centre in southern Nigeria. A cross-sectional study design was employed to assess 200 randomly selected patients attending the clinics. Questionnaires were administered to obtain sociodemographic and medical history data. The perceived stress scale (PSS) was used to determine the presence of subjective psychological stress and PHQ-9 was used to screen for depression. The prevalence of depressive symptoms was 54.9% with 16.5% categorised as having major depression. After adjusting for confounding variables, age younger than 60 years was associated with less odds of having depressive symptoms (AOR 0.32, 95% CI 0.17, 0.62; p=0.001), while only significant psychological stress increased the odds of having depressive symptoms (AOR 2.78, 95% CI 1.37, 5.64; p=0.005). The prevalence of depression among the study participants is high and has the potential to significantly impact the control of their disease and ultimately contribute to the high cardiovascular risk faced by this population.
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Salako, Omolola, Alero A. Roberts, Victor I. Isibor, Oluwatimilehin Babatunde, Omolara Fatiregun, and Chukwumere N. Nwogu. "Innovative Breast Cancer Awareness and Advocacy Campaign." Journal of Global Oncology 3, no. 2 (April 2017): 169–76. http://dx.doi.org/10.1200/jgo.2016.003509.
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Breast cancer is a major disease in Nigeria; in 2012, 27,304 new occurrences were diagnosed, and the number of mortalities was 13,960. Greater than 70% of patients present with advanced disease, which has a poor survival outcome. The mortality rates are high mainly because of a lack of awareness about breast health, screening guidelines, and treatment centers, and because of sociocultural barriers. In Nigeria, health care professionals remain the backbone for the provision of medical information to the public. This is a study of the innovative ways that breast health and cancer awareness were promoted across communities and institutions in Lagos State, Nigeria, in 2015. Several community awareness campaigns were carried out in the forms of health talks, breast cancer screenings, radio and television interviews, and campaigns on social media. Anomalies noticed during the screenings were promptly referred to appropriate hospitals for additional treatment. The campaign culminated in the #12KLLP, or 12,000 people light Lagos pink, which was a Guinness World Record attempt for the largest human awareness ribbon formed for breast cancer. There was a total reach of 28,774,812 people across platforms: 285,318 were on social media, 3,620 were in communities, 7,466,276 were on the website, 20 million were through media events, 12,000 were through publications, 7,598 were verified participants at the Guinness World Record, and approximately 1 million were through blogs. Eighty partnerships were made with various private and government institutions to facilitate different aspects of the campaign. The community members were able to learn about the need for early detection and awareness; volunteerism and corporate social responsibility were promoted among individuals and corporate institutions.
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Abdu, Lawan. "Epidemiological Properties of Primary Open Angle Glaucoma in Nigeria." Journal of Ophthalmology 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/402739.
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Background. Primary open angle glaucoma (POAG) is progressive chronic optic neuropathy in adults in which intraocular pressure (IOP) and other currently unknown factors contribute to damage. POAG is the second commonest cause of avoidable blindness in Nigeria.Pattern of Presentation. POAG is characterized by late presentation. Absence of pain which is a driving force for seeking medical help, inadequacy of trained eye care personnel, paucity of facilities, misdistribution of resources, lack of awareness, poor education, and poverty may all contribute to this. Medical and surgical treatment options available are challenging and tasking.Screening for Glaucoma. Screening is the presumptive identification of unrecognized disease (POAG) by applying test(s) which can be applied rapidly. Such test(s) should be of high reliability, validity, yield, acceptable, and cost effective. The test should ideally be sensitive, specific, and efficient. It is difficult to select a suitable test that meets these criteria. Intraocular pressure (IOP) appears to be the easiest option. But, high IOP is not diagnostic nor does normal value exclude the disease. Health education is a possible strategy in early case detection and management.Treatment of POAG. Glaucoma treatment can either be medical or surgical (this includes laser). Considering unavailability, potency, cost, and long-term effects of medication, surgery (trabeculectomy) could be a better option. Laser trabeculoplasty is available in a few centers. Viscocanalostomy is not routinely performed. Patient education is vital to success as management is for life.Conclusion. POAG remains a cause of avoidable blindness in Nigeria. There is need for long-term strategy to identify patients early and institute prompt management. Improvement in training of eye care personnel and provision of up to date equipment is essential in achieving this goal.
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Oyeyemi, Oyetunde T., and Edet J. Etim. "Malaria and HIV Infection among Febrile Patients in a Large Area of Southwestern Nigeria." Journal of Interdisciplinary Medicine 5, no. 2 (June 1, 2020): 43–47. http://dx.doi.org/10.2478/jim-2020-0011.
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AbstractBackground: Malaria and HIV/AIDS are two major diseases that represent serious public health threats in Nigeria. They have been ascribed diseases of poverty, and therefore their distribution is expected to be overlapping.Aim: The aim of this study was to determine the prevalence of malaria parasites and HIV among febrile patients in the Ikeja area of Lagos State, Nigeria.Materials and Methods: The study was conducted on 300 patients attending medical consultation and referred to blood screening for malaria parasites at Reddington Hospital, Lagos State. Malaria parasites were identified microscopically, and HIV screening was carried out using rapid diagnostic tests (RDT).Results: The prevalence of malaria and HIV was 98.7% and 3.7%, respectively. All HIV-positive individuals were also infected by malaria parasites. Mean parasitemia was significantly higher in HIV-positive individuals (16,507.9 ± 2,280.7 P/μL) than in HIV-negative subjects (3,252.505 ± 236.3 P/μL) (p <0.05).Conclusions: Our results suggest that HIV-infected individuals are more susceptible to infection with malaria parasites. Prompt HIV management is necessary in malaria-endemic areas to reduce disease severity in case of coinfection with HIV.
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Eguzo, Kelechi N., Adegboyega Lawal, Chukwuemeka Oluoha, Kingsley Nnah, Uwemedimbuk Ekanem, Nancy Onwueyi, and Onyechere Nwokocha. "Clinical Pathway and Patient Navigation: Research Protocol on the Appropriateness, Timeliness and Support of Women Diagnosed with Breast Cancer in Abia Stat." Asian Pacific Journal of Cancer Care 6, no. 3 (July 23, 2021): 367–71. http://dx.doi.org/10.31557/apjcc.2021.6.3.367-371.
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Background: Breast cancer is the second most common malignancy affecting Nigerian women, and contributes the highest cancer-related mortality in this population. Despite the rising prevalence of breast cancer, Nigerian healthcare professionals do not have adequate resources in screening, diagnosing, treating and follow up of women with breast cancer. The objective of this study was to understand how the development and implementation of a state-wide clinical pathway alongside a patient navigation program will impact the care providers and care receiver (beast cancer patients). Methods: This mixed methods, cross-sectional study will develop and deploy a multidisciplinary clinical pathway focused on breast cancer management. Trained patient navigators will facilitate the implementation of the pathway and to support patients. An electronic medical record system will be deployed to document the use of the pathway. Mixed methods data will be collected periodically, including patient satisfaction, treatment adherence, psychosocial outcomes, and quality of life. Qualitative data will provide contextual details.Anticipated Result and Discussion: This research will potentially structure the management of breast cancer in a way that optimizes available resources while reducing delays in Abia state, Nigeria.
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Emeakpor Ogbetere, Friday, and Yemihan Nwannebuife Ogbetere. "Sociodemographic Determinants of the Level of Knowledge of Prostate Cancer and Prostate Cancer Screening Services among Patients Attending a Secondary Health Facility in Southern Nigeria." Sumerianz Journal of Medical and Healthcare, no. 41 (February 15, 2021): 15–22. http://dx.doi.org/10.47752/sjmh.41.15.22.
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Background: Late presentation of prostate cancer is rampant in sub-Saharan Africa with attendant high morbidity and mortality. A good knowledge level of prostate cancer and prostate cancer screening services is paramount in preventing late presentation and its management challenges. This study assesses the sociodemographic factors affecting the knowledge level of prostate cancer and prostate cancer screening tools and services among patients attending a secondary health facility in southern Nigeria. Methods: This was a descriptive cross-sectional study amongst men aged 40 years and above attending the general outpatient, surgical outpatient, and medical outpatient clinics in Central Hospital, Auchi, southern Nigeria. A pretested and structured questionnaire was used. Sociodemographic determinants of the knowledge level of prostate cancer and prostate cancer screening were determined based on responses to the questionnaire. Data were analyzed using SPSS version 21. The level of significance was set at 0.05. Results: A total of 143 men participated in this study. Respondents’ age range was between 40 to 98 years with a mean age of 58.91±13.55 years. Overall, 55(38.5%) respondents had good knowledge of prostate cancer while 43(30.1%) had good knowledge of prostate cancer screening. A third (31.2%) think they are at risk of developing prostate cancer, only 9.1% had been screened for prostate cancer. In all, 86.7% of respondents were willing to know more and to be screened in the future. Whereas, age, occupation, average monthly income, and level of education were the statistically significant sociodemographic predictors of level of knowledge of prostate cancer, the only factors that influenced the level of knowledge of prostate cancer screening services were occupation and educational status. Conclusion: Knowledge level about prostate cancer disease and prostate cancer screening services was low among men attending outpatient clinics in Auchi Central Hospital. Respondents’ age, occupation, average monthly income, and level of education significantly affect their prostate cancer knowledge level while knowledge of prostate cancer screening services was determined by the occupation and educational status of the respondents. Interventional campaigns aimed at increasing the knowledge level about prostate cancer and screening services are urgently required.
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Amadi, Casmir, Folasade Lawal, Wale Ajiboye, Rosarii Agbim, Amam Mbakwem, Jayne Ajuluchukwu, and David A. Oke. "Opportunistic screening of cardiovascular disease risk factors in community pharmacies in Nigeria: a cross-sectional study." International Journal of Clinical Pharmacy 42, no. 6 (September 22, 2020): 1469–79. http://dx.doi.org/10.1007/s11096-020-01112-2.
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OKUONGHAE, D., and V. U. AIHIE. "OPTIMAL CONTROL MEASURES FOR TUBERCULOSIS MATHEMATICAL MODELS INCLUDING IMMIGRATION AND ISOLATION OF INFECTIVE." Journal of Biological Systems 18, no. 01 (March 2010): 17–54. http://dx.doi.org/10.1142/s0218339010003160.
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Optimal control theory is applied to a system of ordinary differential equations modeling the population dynamics of tuberculosis with isolation and immigration of infective. Seeking to minimize the number of infectious individuals and reduce the transmission of the disease, we use controls to represent the screening/medical testing of infected immigrants into the population as well as isolation of infective in the population. The optimal controls are characterized in terms of the optimality system, which is solved numerically for several scenarios using an iterative method with Runge-Kutta fourth order scheme. Parameter values used are those reported for Nigeria.
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Fraiwan, Arwa, Muhammad Noman Hasan, Ran An, Amy J. Rezac, Nicholas J. Kocmich, Tolulope Oginni, Grace Mfon Olanipekun, et al. "Advancing Healthcare Outcomes for Sickle Cell Disease in Nigeria Using Mobile Health Tools." Blood 134, Supplement_1 (November 13, 2019): 2173. http://dx.doi.org/10.1182/blood-2019-131344.
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Nigeria leads the world in the number of cases of sickle cell disease (SCD). An estimated 150,000 babies are born annually in Nigeria with SCD, a heredity disorder, and 70-90% die before age 5. Only a small portion of affected infants and children in sub Saharan Africa (SSA) reach adolescence. Over 650 children die per day in sub-Saharan Africa from SCD. These dismal statistics are in sharp contrast to outcomes in high-income countries (HICs) where more than 90% of SCD patients reach adulthood. The World Health Organization (WHO) estimates that 70% of deaths could be prevented with a low cost diagnostic and treatment plan. Meaningful preventive care and treatment cannot be implemented without a structured plan for early diagnosis and patient tracking.Early diagnosis requires improved access to parents and guardians of children with SCD, and gaining this access remains a challenge in most of SSA. In 2015, Nigeria's Kano state government, with support from foreign partners, established a community-based program for newborn registration. This platform provides unique access to newborn babies in one of Nigeria's most populous cities, but still lacks a functioning patient testing, tracking, and monitoring system, which we plan to address in our ongoing study. This study will introduce mobile health in a low-income country with low literacy rate and hopefully accustom that segment of the population to more varied mobile health applications that will ultimately improve their health in the long run. Our current operational platform in Kano, Nigeria provides access to a large population with a high prevalence of SCD. We have previously completed pilot testing of 315 subjects for SCD using our microchip electrophoresis test. We are planning to test up to 4,500 additional subjects less than 5 years of age at Murtala Muhammed Specialist Hospital. The hospital staff includes 97 physicians and 415 nurses and outpatient clinics serve about 30,000 patients monthly. The maternity department has a 200-bed capacity and the antenatal clinic performs about 1,000 deliveries and serves an average of 3,000 mothers monthly. Enrollment is planned to start on September 15, 2019 and medical staff are currently being trained to run the tests. Our study is registered in the United States National Library of Medicine's ClinicalTrials.gov (Identifier: NCT03948516). Our technology is uniquely paired with an automatic reader and an Electronic Medical Record (EMR) and patient management solution to record POC test results, register new cases, and track patients for follow-up (Fig. 1). The reader enables automated interpretation of test results, local and remote test data storage, and includes geolocation (Global Positioning System) (Fig. 2). The system will generate reports for all cases of SCD, track hospital visits, appointments, lab tests, and will have mobile and dashboard applications for tracking patients and samples. The application will be installed on mobile devices provided to users. The proposed system will be compliant with the existing privacy standards to handle medical data (e.g., HIPAA in the US and GDPR in the EU). All communications between the parties will be secured via end-to-end encryption as a safeguard. We anticipate that our project will increase the rates of screening, diagnosis and timely treatment of SCD in Kano State of Nigeria. The project's broader impact will likely be the ability to track and monitor screening, disease detection, diagnosis and treatment, which can be scaled up to the whole nation of Nigeria, then to sub-Saharan Africa. The data obtained and analyzed will be the first of their kind and will be used to inform the design of programs to improve access to, and availability of, effective care for this underserved populations. The importance of increased access to diagnosis and treatment should not be underestimated - it is crucial for realizing effective management of people with SCD. The impact can be enhanced by complementing diagnosis and patient tracking with education for the families so they can provide or seek the necessary preventative treatment. Identification of the location of the patients in need would help identify the areas where family, parent, caregiver education should be provided. Disclosures Fraiwan: Hemex Health, Inc.: Equity Ownership, Patents & Royalties. Hasan:Hemex Health, Inc.: Equity Ownership, Patents & Royalties. An:Hemex Health, Inc.: Patents & Royalties. Thota:Hemex Health, Inc.: Employment. Gurkan:Hemex Health, Inc.: Consultancy, Employment, Equity Ownership, Patents & Royalties, Research Funding.
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Ajetunmobi, Olanrewaju I., and Donatus O. Dzuachii. "Dermatologic neoplasms: a perspective from Makurdi, North Central Nigeria." International Journal of Research in Dermatology 3, no. 3 (August 24, 2017): 395. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20173920.
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<p class="abstract"><strong>Background:</strong> Skin cancers are the commonest malignancies in Caucasians but are relatively less common in dark skinned persons. They are strongly linked to ultraviolet exposure, skin melanin content, and immune status.</p><p class="abstract"><strong>Methods:</strong> This study reviewed all histologically diagnosed skin neoplasms at the Federal Medical Centre, Makurdi from January 2012 to December 2016.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total of 84 neoplasms were seen, with 42 (50%) being malignant. Of the malignant lesions, Squamous cell carcinomas were the most frequent (45.2%), followed by melanomas (23.8%). The lower limb was the most frequent site of both benign and malignant neoplasms, while a male to female ratio of 0.88:1 was observed.</p><p><strong>Conclusions:</strong> A relatively high UV radiation intensity, combined with a predominance of outdoor agricultural based activities, alongside chronic ulcerative/inflammatory lesions and a high HIV burden all indicate a need for widespread enlightenment and screening campaigns to prevent occurrence of skin cancers and aid early diagnosis.</p>
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Ezeome, R. E. "Delays in presentation and treatment of breast cancer in Nigeria." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 1527. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.1527.
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1527 Background: Programs on breast cancer prevention inresource poor countries often emphasize cost effective interventions to increase the uptake of screening, breast awareness, and the use of breast self examination. The success of such programs depends on the response of women and health professionals to the presence of symptoms of breast cancer. Understanding the factors at play in these responses is a prerequisite for strategies to shorten delays and improve stage at diagnosis. This study was designed to assess the delays and define the causes of delays in getting medical treatment by patients with breast cancer at University of Nigeria Teaching Hospital Enugu, (UNTH-E), Nigeria. Methods: A cross-sectional survey of consecutively presenting patients with breast cancer at the Surgical Oncology unit of the UNTH-E, Nigeria, was carried out between June 1999 and May 2005. A structured questionnaire was used to explore delays and the factors that influence delays in presentation and treatment of breast cancer. Results: One hundred and sixty four patients with breast cancer were interviewed. Most of them were married (71.2%), literate (84.7%), low (58.8%) or middle socioeconomic class (40%), and had access to hospitals within their area of residence. Most (81.6%) reported first for treatment at a modern health facility while 17.5% used alternative practitioners first. Twenty-six percent (42) presented within a month of noticing the symptoms while 45.3% (72) delayed for 3 months or more. In contrast, 17% (18) were seen at the site of definitive treatment within 1 month of seeking help at the initial hospital while 73.4% had a delay of more than 3 months after the initial hospital contact. Institutional or physician related delays were present in 44.5% of the cases while patient-related delays were present in 76.7% of cases. Only use of alternative practitioners as the first treatment point was significantly related to delays of more than 3 months before presentation (p = 0.029). Conclusions: For breast cancer prevention programs in Nigeria to succeed, they must, in addition to breast awareness and screening programs, address the institutional bottlenecks, the dearth of knowledge among primary care physicians, and improved referrals from alternative practitioners. No significant financial relationships to disclose.
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Edoghogho Omorogbe, Christie. "Awareness and Uptake of Cervical Cancer Screening Among Female Students in School of Basic Medical Sciences, University of Benin, Nigeria." American Journal of Nursing Science 8, no. 4 (2019): 169. http://dx.doi.org/10.11648/j.ajns.20190804.17.
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Twahir, Majid, Razaq Oyesegun, Joel Yarney, Andrew Gachii, Clement Edusa, Chukwumere Nwogu, Gitangu Mangutha, et al. "Real-world challenges for patients with breast cancer in sub-Saharan Africa: a retrospective observational study of access to care in Ghana, Kenya and Nigeria." BMJ Open 11, no. 3 (March 2021): e041900. http://dx.doi.org/10.1136/bmjopen-2020-041900.
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ObjectiveTo evaluate medical resource utilisation and timeliness of access to specific aspects of a standard care pathway for breast cancer at tertiary centres in sub-Saharan Africa.DesignData were retrospectively abstracted from records of patients with breast cancer treated within a prespecified 2-year period between 2014 and 2017. The study protocol was approved by local institutional review boards.SettingSix tertiary care institutions in Ghana, Kenya and Nigeria were included.ParticipantsHealth records of 862 patients with breast cancer were analysed: 299 in Ghana; 314 in Kenya; and 249 in Nigeria.InterventionsAs directed by the treating physician.Outcome measuresParameters selected for evaluation included healthcare resource and use, medical procedure turnaround times and out-of-pocket (OOP) payment patterns.ResultsUse of mammography or breast ultrasonography was <45% in all three countries. Across the three countries, 78%–88% of patients completed tests for hormone receptors and human epidermal growth factor receptor 2 (HER2). Most patients underwent mastectomy (64%–67%) or breast-conserving surgery (15%–26%). Turnaround times for key procedures, such as pathology, surgery and systemic therapy, ranged from 1 to 5 months. In Ghana and Nigeria, most patients (87%–93%) paid for diagnostic tests entirely OOP versus 30%–32% in Kenya. Similarly, proportions of patients paying OOP only for treatments were high: 45%–79% in Ghana, 8%–20% in Kenya and 72%–89% in Nigeria. Among patients receiving HER2-targeted therapy, the average number of cycles was five for those paying OOP only versus 14 for those with some insurance coverage.ConclusionsPatients with breast cancer treated in tertiary facilities in sub-Saharan Africa lack access to timely diagnosis and modern systemic therapies. Most patients in Ghana and Nigeria bore the full cost of their healthcare and were more likely to be employed and have secondary or postsecondary education. Access to screening/diagnosis and appropriate care is likely to be substantively lower for the general population.
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Inyang-Etoh, Paul Columba, Abasiodiong Udom Akpan, Victor Udo Usanga, and Gabriel Chuks Ejezie. "Asymptomatic Bacteriuria amongst Menopausal women in Calabar, Nigeria." Asian Journal of Medical Sciences 9, no. 4 (July 2, 2018): 51–56. http://dx.doi.org/10.3126/ajms.v9i4.19740.
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Background: Bacteriuria is considered a common bacterial infection in women particularly in postmenopausal women which consequently may warrant the need to treat the disease for prevention of bacteriuria developing complications.Aims and Objectives: This work was to investigate the prevalence of asymptomatic bacteriuria among menopausal women in Calabar, the incriminating bacterial pathogens and their antibiotic susceptibility pattern. Materials and Methods: Early morning mid stream urine samples from randomly selected 200 women (comprising of 50 premenopausal, 50 menopausal, 50 postmenopausal women and 50 apparently healthy young ladies of menstruating age (control subjects)) between the ages of 50 to 90 years were cultured by Leigh and Williams’s method. Questionnaires were also administered.Results: 24 (16%) of the test group while 3 (6%) of the control group had infection (p=0.008). Subjects aged 35-40 years had the highest prevalence of infection 6 (18.5%), while age group 66-70yrs had the lowest infection rate 0(0%)( P = 0.841). Post-menopausal women had the highest prevalence of asymptomatic bacteriuria 10(20%) while pre-menopausal and menopausal women had a lower prevalence rate of 7 (14%) each (p=0.0687). The most frequently isolated organism was Staphylococcus aureus (33%) and Ciprofloxacin was the most sensitive antibiotic observed.Conclusion: This work has revealed a high prevalence rate of asymptomatic bacteriuria high level of asymptomatic bacteriuria among menopausal women and the need for routine screening of this category of women for a standard healthy living.Asian Journal of Medical Sciences Vol.9(4) 2018 51-56
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Ogbole, Omonike O., Toluwanimi E. Akinleye, Peter A. Segun, and Pius S. Fasinu. "Antiprotozoal investigation of three Combretum species (Combretaceae) growing in Nigeria." Herba Polonica 65, no. 4 (December 1, 2019): 37–44. http://dx.doi.org/10.2478/hepo-2019-0024.
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SummaryIntroduction:Combretum species has been utilised for decades in African indigenous medical practices for the treatment of several parasitic infections.Objectives: This study aims at investigating the antileishmanial, antiplasmodial and antitrypanosomal properties of Combretum racemosum, Combretum platypterum and Combretum zenkeri.Methods: The leaf extracts of the plants were screened against two strains of Plasmodium falciparum using Plasmodium lactate dehydrogenase (pLDH) assay; promastigote and amastigote forms of Leishmania donovani; and Trypanosoma brucei brucei using Alamar Blue assay. Cytotoxicity screening were also carried out on African green monkey kidney cell line (Vero) and human monocytic leukemia (THP-1) cell lines.Results:C. racemosum was active against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of P. falciparum (IC50 of 25.6 and 26.7 µg/ml, respectively) and exerted significant antiprotozoal activities against T. brucei brucei (IC50 = 18.44 µg/ml). The extract of C. platypterum displayed a slightly lower antiplasmodial activity when compared to C. racemosum, while C. zenkeri was inactive against the parasites. In addition, the extracts failed to display significant inhibitory activity on the proliferation of L. donovani.Conclusions: This study supports the ethnomedicinal use of C. racemosum. Further research needs to be carried out to identify the antiprotozoal compounds in C. racemosum, as this could be explored for possible antiprotozoal drug development.
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Akande-Sholabi, Wuraola, Oluwatobi C. Ajilore, Segun J. Showande, and Lawrence A. Adebusoye. "Potential inappropriate prescribing among ambulatory elderly patients in a geriatric centre in southwestern Nigeria: Beers criteria versus STOPP/START criteria." Tropical Journal of Pharmaceutical Research 19, no. 5 (June 29, 2020): 1105–11. http://dx.doi.org/10.4314/tjpr.v19i5.29.
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Purpose: To identify potentially inappropriate prescribing in ambulatory elderly patients and compare the appropriateness of guidelines; Beers' and Screening Tool of Older Person’s Prescription (STOPP)/Screening Tool to Alert Right Treatment (START) criteria to detect potentially inappropriate prescribing among the elderly.Methods: A retrospective study was conducted using case files of 335 elderly patients aged ≥ 60 years between 1st January and 31st December 2016, using a data extraction sheet. The 2015 American Geriatrics Society (AGS)-Beers Criteria, and version 2 of the STOPP and START were subsequently used to identify the Potentially Inappropriate Prescribing (PIP) and Potential Prescribing Omissions (PPOs).Results: Mean age of patients was 69 ± 0.4 years (range 60 - 85 years) and 219 (65.4 %) were females. An average of 4.2 medications per patient prescription was found. The Beers criteria identified 26.5 % PIP, while STOPP criteria identified 57.1 % PIP. START detected 29 PPOs in 15 (4.4 %) of the patient’s prescription. The most prevalent disease conditions were hypertension 235 (70.1 %) and osteoarthritis 64 (19.3 %). Polypharmacy was significantly associated with PIP in both Beers (p = 0.002) and STOPP (p = 0.001) criteria.Conclusion: The prevalence of PIP is high among elderly patients. The STOPP/START criteria identified a higher proportion of PIP among elderly patients compared with Beers criteria. The frequency of PIP should stimulate efforts to curtail potentially inappropriate prescribing and may require the need for advocating for a national criterion to be adopted by health care professionals in Nigeria.
Keywords: Potential inappropriate prescribing, Beers’ criteria, STOPP/START criteria, Elderly
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Ugwu, Ngozi Immaculata. "Pattern of ABO and Rhesus blood group distribution among students of Ebonyi State University, Abakaliki, South Eastern Nigeria." Asian Journal of Medical Sciences 7, no. 1 (August 28, 2015): 101–4. http://dx.doi.org/10.3126/ajms.v7i1.12716.
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Aims and Objectives: The objective of this study is to have information on the distribution of ABO and Rhesus blood group among the students so as to determine the need for routine screening for hemolysin among blood group O, if found to be high, as well as to institute blood donor registry for Rhesus negative blood, if found to be low.Materials and Methods:This was a retrospective study and record of ABO and Rhesus blood group results of students screened between May 2010 and April 2011 was obtained from the University medical centre. Data was analyzed using Epi info software, version 3.5.4. Descriptive statistics were used to compute percentages and averages. Results were presented in tables and charts and expressed as percentages/proportions, mean and standard deviation.Results: Three thousand, two hundred and eighty three results were obtained, made up of 1749 males and 1534 females with the ratio of 1.1:1. The age of the students ranged between 16 and 47 years with mean age of 22 ± 5years. Among the population studied, blood group O has the highest percentage (57.7%), followed by group A (22.1%), then B (18.1%), while AB has the least percentage (2.1%). Most of the students were found to be Rhesus positive (95.8%), while Rhesus negative was 4.2%.Conclusion: Blood group O was found to be highest among the study population, followed by A, B and AB in that order. Most of the students were found to be Rhesus positive while only a minority were Rhesus negative. Routine screening for hemolysin among blood group O and institution of blood donor registry is recommended.Asian Journal of Medical Sciences Vol.7(1) 2015 101-104
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Hasan, Muhammad Noman, Arwa Fraiwan, Priyaleela Thota, Tolulope Oginni, Grace Mfon Olanipekun, Fatimah Hassan-Hanga, Jane Little, Stephen K. Obaro, and Umut A. Gurkan. "Clinical Testing of Hemechip in Nigeria for Point-of-Care Screening of Sickle Cell Disease." Blood 132, Supplement 1 (November 29, 2018): 1095. http://dx.doi.org/10.1182/blood-2018-99-115355.
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Abstract In sub-Saharan Africa, nearly a quarter of a million babies are born with sickle cell disease (SCD) each year. An estimated 50-90% of these babies die before age 5 due to lack of early diagnosis and timely treatment. The World Health Organization estimates that more than 70% of SCD related deaths are preventable with simple, cost-effective interventions, such as early screening followed by affordable and widely available treatment regimens. Here, we present the early clinical testing results of HemeChip, which is the first single-use cartridge-based microchip electrophoresis hemoglobin screening platform. HemeChip was developed by Hemex Health, Inc., based on technology licensed from Case Western Reserve University. HemeChip allows affordable, objective, quantitative screening of hemoglobin variants at the point-of-care. HemeChip works with a drop of finger or heel-prick blood and separates hemoglobin variants on a piece of cellulose acetate paper that is housed in an injection molded plastic cartridge with a precisely controlled electric field. HemeChip works with a portable reader to produce easily understandable, objective, and quantitative descriptions of the hemoglobin types and percentages present in a blood sample. The HemeChip reader guides the user step-by-step through the test procedure with animated on-screen instructions to minimize user errors. Hemoglobin identification and quantification is automatically done with a custom software on the reader. HemeChip reader records and analyzes the hemoglobin electrophoresis real-time, and it can wirelessly transmit the test results to a central electronic database, if needed. HemeChip prototype units have been clinically tested and benchmarked against the clinical standard technique in Kano, Nigeria, where the SCD prevalence is the highest in the world. We tested a total of 248 subjects (228 children aged 6 weeks to 5 years in Kano, Nigeria; and 20 adults in Cleveland, Ohio, United States) under institutional review board approval, using both HemeChip and the clinical standard laboratory method, High Performance Liquid Chromatography (HPLC, VARIANT™ II, Bio-Rad Laboratories, Inc., Hercules, California). HemeChip tests were done on eHealth Africa campus in Kano, Nigeria, by trained local healthcare workers using blood samples collected at the nearby Aminu Kano Teaching Hospital. Clinical standard (HPLC) testing was done independently by the International Foundation Against Infectious Disease in Nigeria (IFAIN, Abuja, Nigeria) for the blood samples obtained in Kano or by the University Hospitals Cleveland Medical Center Clinical Laboratories (Cleveland, Ohio) for the blood samples obtained in Cleveland. Test results included the following: homozygous SCD (HbSS), heterozygous sickle hemoglobin C disease (HbSC), heterozygous sickle trait (HbAS), and normal (HbAA). HemeChip identified the subjects with HbSS with 100% accuracy, HbSC with 100% accuracy, HbAS with 98.2% accuracy, and HbAA with 96.4% accuracy in comparison to HPLC (Table 1). Overall accuracy of HemeChip was 97.2% in comparison to HPLC for the subjects tested. HemeChip sensitivity was 100% for all hemoglobin variants tested (Table 2), and specificity was 96.4% for HbSS vs. HbAA, 98.2% for HbSS vs. HbAS, 100% for HbSC vs. HbAS, and 100% for HbAS vs. HbAA. Bland-Altman analysis indicated strong agreement between the quantitative HPLC and HemeChip results for hemoglobin percentages, with a mean bias of -3.2%. HemeChip enables, for the first time, accurate, cost-effective identification and quantification of hemoglobin variants at the point-of-need. HemeChip has been developed based on a versatile, mass-producible microchip electrophoresis platform technology that may address other unmet needs in biology and medicine that require rapid, decentralized hemoglobin or protein analysis, identification, and/or quantification. Disclosures Thota: Hemex Health Inc: Employment. Little:PCORI: Research Funding; Hemex: Patents & Royalties: Patent, no honoraria; NHLBI: Research Funding; Doris Duke Charitable Foundations: Research Funding.
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Ayinmode, B. A., and M. F. Tunde-Ayinmode. "Family violence among mothers seen at the University of Ilorin Teaching Hospital, Ilorin, Nigeria." South African Journal of Psychiatry 14, no. 3 (August 1, 2008): 7. http://dx.doi.org/10.4102/sajpsychiatry.v14i3.163.
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<p><strong>Objective.</strong> The attention given to family violence (FV) in primary medical care in Nigeria is still very insufficient in relation to its known adverse medical and psychosocial implications for women’s health. The objective of this preliminary study was to assess the prevalence rate, correlates and effects of FV among mothers attending a primary care facility in Nigeria, with the aim of gaining an understanding of whether screening for FV in the primary care setting in Nigeria would be beneficial.</p><p><strong>Methodology</strong> . A cross-sectional study of FV among 250 mothers attending the General Outpatient Department of the University of Ilorin Teaching Hospital was undertaken over a 5-month period. Data on the mothers’ sociodemographic characteristics, and experience of FV and its psychosocial correlates and effects were collected using a semi-structured questionnaire and a 20-item Self- Reporting Questionnaire (SRQ) as instruments. <strong></strong></p><p><strong>Data analysis</strong> . EPI Info version 6 was used to analyse the data.<strong> </strong></p><p><strong>Results</strong>. Sixty-nine mothers (28%) had experienced FV at the hands of their husbands. Of these women, 49 (71%) indicated occurrences within the preceding 2 years; in 17 (25%), the violence was severe enough to warrant a hospital visit or treatment. Mothers who experienced FV were significantly more likely to have had previous experiences of violence by an in-law; to have reported child cruelty by a husband; to have children with difficult behaviour; and to have reported that they were neglected by their husbands and not enjoying their marriages. They were also significantly more likely to have a high score on the SRQ and be identified as probable cases with psychological problems (SRQ score ≥ 5). <strong></strong></p><p><strong>Conclusion.</strong> In view of these findings, screening for FV in the primary care setting would be beneficial. Primary care physicians should therefore increase their interest, improve their skill, and carry out more research in the identification and management of FV.</p>
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Anigilaje, Emmanuel Ademola, and Ayodotun Olutola. "Prevalence and Clinical and Immunoviralogical Profile of Human Immunodeficiency Virus-Hepatitis B Coinfection among Children in an Antiretroviral Therapy Programme in Benue State, Nigeria." ISRN Pediatrics 2013 (April 3, 2013): 1–7. http://dx.doi.org/10.1155/2013/932697.
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Background. Nigeria has the world largest burden of paediatric HIV and is also highly endemic for Hepatitis B virus (HBV). However, relatively little is known regarding the prevalence of HBV-HIV coinfections among Nigerian children. Methods. A retrospective study among treatment naive HIV-infected children attending the pediatric clinic of the APIN Plus/Harvard PEPFAR program of the Federal Medical Centre, Makurdi, between June 2008 and June 2012. Results. The mean age of the 395 subjects studied was 7.53±4.23 years. Thirty-one subjects (7.8%) were positive for HBV. No subject was HIV-HBV-HCV triply infected. Significantly higher HIV-HBC coinfections were found, in older subjects (11–15 years), subjects that did not receive nor complete Hepatitis B vaccinations, and subjects that had a severe immunosuppression of < 15% with respective P values of 0.00, 0.01, and 0.00. HIV-HBV co-infection did not significantly impact on other baseline characteristics including, gender, WHO clinical stage, median absolute CD4 count, mean viral load, median ALT, and hepatotoxicity. Conclusion. A high seroprevalence of HBV among this cohort of HIV-infected children contributes to the calls for pre-ART screening for HBV and the necessary paradigm shift in the ART nucleoside backbone to include agent(s) more dually effective against HIV and HBV.
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Filade, Temitope, Eileen Dareng, Toyosi Olawande, Tolani Fagbohun, Amos Adebayo, and Clement Adebamowo. "P-B20 Evaluation of the feasibility of incorporating HPV DNA- based cervical cancer screening into routine antenatal care in Nigeria." JAIDS Journal of Acquired Immune Deficiency Syndromes 71 (January 2016): 81. http://dx.doi.org/10.1097/01.qai.0000479734.06205.a9.
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Shittu, Rasaki O., Louis O. Odeigah, Kasali O. Fakorede, Biliaminu A. Sikiru, Abdullateef G. Sule, Yusuf Musah, and Folorunsho M. Adeyemi. "Prevalence and correlates of hypertension-outcome of a free medical screening in Oke-Ogun area of Oyo state, Nigeria, West Africa." Journal of the American Society of Hypertension 12, no. 4 (April 2018): 268–74. http://dx.doi.org/10.1016/j.jash.2018.01.009.
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Marshman, Laurence A. G., Jonathan R. Pollock, Andrew King, and Sanjiv J. Chawda. "Primary Extradural Epithelioid Leiomyosarcoma of the Cervical Spine: Case Report and Literature Review." Neurosurgery 57, no. 2 (August 1, 2005): E372. http://dx.doi.org/10.1227/01.neu.0000166695.89757.a4.
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ABSTRACT OBJECTIVE AND IMPORTANCE: No case of primary epithelioid leiomyosarcoma involving the spine has been reported previously. CLINICAL PRESENTATION: A 61-year-old Nigerian woman presented with progressive spastic quadriparesis and acute urinary retention. Her only medical history included a total abdominal hysterectomy for fibroids 10 years earlier in Nigeria. Results of the general examination were normal. Pyramidal spastic quadriparesis (3/5) with a sensory level at C5–C6 was found neurologically. Magnetic resonance imaging scans of the brain and spine revealed extradural cord compression at C3–C5 as the sole abnormality. This was caused by a large, soft tissue mass arising from the erector spinae muscles, which was predominantly isointense on T1-weighted images, of mixed intensity on T2-weighted images, and homogenously enhanced after gadolinium contrast agent administration. There was an associated signal change in the cord at C3–C4. Computed tomography confirmed the predominantly soft tissue involvement, but with bone erosion and infiltration within the posterior elements of C4. Systemic screening for cancer was negative. INTERVENTION: At decompressive laminectomy, urgently undertaken under corticosteroid cover, an excessively vascularized, soft tissue tumor was subtotally excised, after which independent walking and normal sphincter function were regained within 1 week. Four weeks later, a complete macroscopic tumor excision was undertaken, incorporating lateral mass (C3–C6) and C2 pedicle screw stabilization, along with iliac crest bone grafting. The patient's neurological status continued to improve. However, while awaiting radical radiotherapy, the patient declined further treatment and returned to her native Nigeria. Histopathological findings were consistent with an epithelioid leiomyosarcoma. CONCLUSION: This is the first reported case of a primary craniospinal epithelioid leiomyosarcoma.
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Nwankwo, E. "MetaPink Program: Simplifying the Breast Cancer Journey for Patients With Advanced Stage Breast Cancer in Nigeria." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 170s. http://dx.doi.org/10.1200/jgo.18.38600.
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Background and context: Breast cancer is the number one diagnosed cancer in Nigeria. 75% of these breast cancer diagnosis are at stage 3 and 4. This is due in part to lack of awareness of the signs and symptoms, inadequate screening and diagnostic facilities, insufficient policies and guidelines, and fear. Metastatic breast cancer patients do not have the time nor the strength to deal with the stress, delay, and confusion of trying to find adequate care. Run For a Cure Africa (RFCA) wishes to establish a program that helps navigate metastatic breast cancer patients in Lagos state, and surrounding states in Nigeria toward breast cancer care and resources. Aim: The MetaPink program empowers and educates patients with advanced stage breast cancer by providing them with timely and relevant information and resources on their disease and how they, the patient, can improve their quality of life and overall prognosis. Additionally, RFCA creates greater awareness of metastatic breast cancer in the community and the necessity for regular screenings. Strategy/Tactics: This project is being implemented by RFCA. RFCA is working work with the health care professionals (HCP) in the oncology and community health department at the Lagos University Teaching Hospital (LUTH) in addition to their organization mentors, The Rose Foundation in Houston, Texas. RFCA is also working with community associations, drama troupes, and groups to create sensitization in hard to access areas. Patients and participants of the MetaPink program have a support team, through the monthly support group, with whom they fellowship, ask advice, gain insight, and just off load any looming concerns. Program/Policy process: RFCA enrolls metastatic patients through our supported clinics, call ins, and our screening outreaches. Each patient enrolled in the program gets a starter pack. RFCA hosts monthly support groups and Q&A sessions anchored by medical professionals, RFCA also hosts community outreach events via the radio, market drama skits, and musical awareness presentations. Periodically we follow-up and communicate with MetaPink program participants via MetaPink WhatsApp, telephone, in-person meetings/visits, and support group meetings. Outcomes: The objective of the MetaPink program is to simplify the breast cancer journey for metastatic breast cancer patients in Nigeria and give them the emotional support and confidence to understand and navigate through their personal breast cancer journey. RFCA also creates larger community awareness of advanced stage breast cancer in a method that is culturally appealing and resonates with the environment. What was learned: As the program progresses, RFCA will learn how to effectively navigate patients in this resource-poor environment. This will contribute to their quality of life and improved breast cancer management in Nigeria. [Figure: see text]
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Onyemelukwe, Obiageli U., and Bilkisu B. Maiha. "Prevalence of hyperhomocysteinaemia, selected determinants and relation to hypertension severity in Northern-Nigerian hypertensives: the ABU homocysteine survey." Ghana Medical Journal 54, no. 1 (March 31, 2020): 17–29. http://dx.doi.org/10.4314/gmj.v54i1.4.
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Background: This study aimed at evaluating the prevalence of hyperhomocysteinaemia in Northern-Nigerian hypertensives and its association with hypertension severity and some major determinants as data regarding these are lackingin sub-Saharan Africa.
Method: A Community-based cross-sectional study done on 120 randomly-selected hypertensive patients who responded to an ABU radio frequency modulated invitation for free health-screening at the Ahmadu Bello University (ABU) Medical Centre from January 2016 to June 2016. The percentage of participants with high homocysteine levels, their anthropometric parameters and blood pressures were determined. Plasma homocysteine (hcy) was classified as normal (5-15), moderate (>15-30), intermediate (31-100) and severe (>100) μmol/L. Kruskal-Wallis test was applied and log-transformed homocysteine (Ln10Homocysteine) was correlated with systolic and diastolic blood pressures as well as age, body mass index, fasting blood glucose, glomerular filtration rate, hypertension duration and Ln10folate in males and females using the Pearson’s Correlation analysis.
Results: There were 83(69.2%) females and 37(30.8%) males with Median homocysteine of 20.8 μmol/L and 22.0 μmol/L respectively (p=0.003). Hyperhomocysteinaemia was found in 118(98.3%) hypertensives while 2(1.7%) subjects had normo-homocysteinaemia. Moderate hyperhomocysteinaemia (Median, 20.8 μmol/L) was identified in 105(87.5%) and intermediate (Median, 40 μmol/L) in 13(10.8%) (p<0.001). No subject had severe hyperhomocysteinaemia.Homocysteine was higher (p=0.003) in subjects with Stage 2 systolic hypertension. Ln10Homocysteine was significantly (p<0.001) correlated with blood pressure (SBP: r=0.45; DBP: r=0.40) and age (r=0.33).
Conclusion: The prevalence of hyperhomocysteinaemia in North-Western Nigerian hypertensives is high as against normal healthy controls. Plasma homocysteine is higher with severe systolic hypertension and positively associated with age.
Keywords: Hypertension, Homocysteine, Blood pressure, Northern-Nigerians
Funding: No specific grants but Micro Nova Pharmaceuticals Limited, Nigeria and Emzor Pharmaceutical Industries, Lagos, Nigeria supported with drugs.