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1

Wakai, Eri, Kenji Ikemura, Chika Kato, and Masahiro Okuda. "Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension." PLOS ONE 16, no. 6 (2021): e0252944. http://dx.doi.org/10.1371/journal.pone.0252944.

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Introduction Good adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medication adherence. However, the effect of medication regimen complexity on the therapeutic efficacy of medicines remains to be clarified. In the present study, we retrospectively investigated the effect of number of medications and medication regimen complexity on medication adherence and therapeutic efficacy in patients wit
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Chang, Wei Terk. "Medication Regimen Complexity Index." Senior Care Pharmacist 35, no. 2 (2020): 50–51. http://dx.doi.org/10.4140/tcp.n.2020.50.

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Balodiya, Sujit, and Ashwin Kamath. "Evaluation of Hospital Discharge Prescriptions in the Elderly and Younger Adults Using the Medication Regimen Complexity Index." Current Drug Safety 14, no. 2 (2019): 116–21. http://dx.doi.org/10.2174/1574886314666181207105118.

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Background:Advances in the clinical management of diseases have been accompanied by increasing complexity of treatment regimens. The complexity of medication regimen is of concern for patients as well as doctors as it may adversely affect patient compliance and treatment outcomes. It may result in medication errors, increased utilization of health resources owing to a reduction in treatment effectiveness, and increased risk of therapeutic failure. Objective:This study aimed to assess the complexity of medication regimen prescribed to patients on hospital discharge using the medication regimen
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Summers, Kent H. "Medication Therapy Management Versus Drug Regimen Review." Journal of Managed Care Pharmacy 13, no. 1 (2007): 68–69. http://dx.doi.org/10.18553/jmcp.2007.13.1.68.

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Boudreaux, Arlene, Ryan F. Schell, Scott D. Nelson, Fenna Phibbs, Jessica Stroh, and Amanda Fraley Depp. "Improving Medication Management for Inpatients with a Secondary Diagnosis of Parkinson Disease." AJN, American Journal of Nursing 124, no. 5 (2024): 50–57. http://dx.doi.org/10.1097/01.naj.0001016384.47848.89.

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ABSTRACT Patients who have Parkinson disease require individualized medication regimens to optimize care. A review of the medication management of patients admitted to a tertiary care hospital with a secondary diagnosis of Parkinson disease found significant departures from the patients' home regimen. Medication regimens are often altered by health care teams unfamiliar with Parkinson disease–specific care in order to conform to standard hospital medication orders and administration times, potentially resulting in increased patient falls, delirium, and mortality. A nurse-led multidisciplinary
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Gualtieri, Lisa, Meredith Steinfeldt, Eden Shaveet, Brandon Estime, and Meera Singhal. "The Impact of Home Medication Management Practices on Medication Adherence." Behavioral Sciences 14, no. 9 (2024): 804. http://dx.doi.org/10.3390/bs14090804.

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Background: Medication adherence is a vexing challenge, with over 50% of US adults not adhering to their prescribed medication regimen. Most medications are self-administered by patients at home, requiring them to independently develop and manage their own medication routines. By understanding these home-based practices, such as where patients store their medications and how different storage locations impact adherence, we can develop targeted interventions to improve adherence rates. Objectives: Our goal was to identify and categorize home medication management practices and determine which p
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Graumlich, James F., Huaping Wang, Anna Madison, et al. "Effects of a Patient-Provider, Collaborative, Medication-Planning Tool: A Randomized, Controlled Trial." Journal of Diabetes Research 2016 (2016): 1–16. http://dx.doi.org/10.1155/2016/2129838.

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Among patients with various levels of health literacy, the effects of collaborative, patient-provider, medication-planning tools on outcomes relevant to self-management are uncertain.Objective. Among adult patients with type II diabetes mellitus, we tested the effectiveness of a medication-planning tool (Medtable™) implemented via an electronic medical record to improve patients’ medication knowledge, adherence, and glycemic control compared to usual care.Design. A multicenter, randomized controlled trial in outpatient primary care clinics. 674 patients received either the Medtable tool or usu
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Pouranayatihosseinabad, Mahsa, Tabish Syed Zaidi, Gregory Peterson, Prasad S. Nishtala, Paul Hannan, and Ronald Castelino. "The impact of residential medication management reviews (RMMRs) on medication regimen complexity." Postgraduate Medicine 130, no. 6 (2018): 575–79. http://dx.doi.org/10.1080/00325481.2018.1502016.

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Branham, Ashley, Joseph Moose, and Stefanie Ferreri. "Retrospective Analysis of Medication Adherence and Cost Following Medication Therapy Management." INNOVATIONS in pharmacy 1, no. 1 (2010): 12. http://dx.doi.org/10.24926/iip.v1i1.195.

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Objective: To determine if pharmacist-provided medication therapy management (MTM) improves medication adherence in Medicare patients. A secondary objective is to compare the total monthly cost of a patient's prescription medication regimen 6 months before and 6 months following a comprehensive medication review (CMR).
 Design: Retrospective analysis of medication adherence, pre-post comparison.
 Setting: Three independent pharmacies in North Carolina.
 Patients: 97 Medicare Part D beneficiaries with one or more chronic disease states who participated in a comprehensive medicati
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Sano, Ugene. "Finding the Balance: Review of Pharmacological Management of Orthostatic Hypotension in Patients With Parkinson's Disease." Journal of Gerontological Nursing 50, no. 12 (2024): 5–10. https://doi.org/10.3928/00989134-20241113-02.

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Purpose Orthostatic hypotension (OH) is a common manifestation of Parkinson's disease (PD). Factors including autonomic dysfunction from the disease, use of PD medications, comorbidities, and aging can contribute to an increased risk of OH, which can be detrimental to patients' quality of life. Maintaining a fine balance to prevent harm related to OH and retain the benefit medications used to treat PD is crucial. The current article reviews various considerations in selecting and adjusting pharmacotherapy for OH in patients with PD. Method Current evidence and guidance on pharmacological strat
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Poojar, Basavaraj, Ashwin Kamath, Sathish B. Rao, et al. "A Prospective Study of the Medication Regimen Complexity Index and Hospitalization Due to Adverse Drug Reactions Among People Living with HIV." Medicina 60, no. 10 (2024): 1705. http://dx.doi.org/10.3390/medicina60101705.

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Background and Objective: The complexity of antiretroviral therapy (ART) regimens in people living with HIV (PLHIV) poses significant challenges for medication management, impacting adherence and overall health outcomes. The Medication Regimen Complexity Index (MRCI) is a tool that quantifies regimen complexity, yet its correlation with hospitalization rates and adverse drug reactions (ADRs) in PLHIV remains underexplored. Materials and Methods: This prospective study, which was conducted at a government-funded antiretroviral treatment center, investigated the relationships among MRCI scores,
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Advinha, Ana Margarida, Carla Teixeria De Barros, Maria Pereira Guerreiro, Carla Nunes, Manuel José Lopes, and Sofia De Oliveira-Martins. "Cross-cultural validation and psychometric evaluation of the Self-Medication Assessment Tool (SMAT) for assessing and optimizing medication therapy management of older people." European Journal for Person Centered Healthcare 6, no. 4 (2018): 655. http://dx.doi.org/10.5750/ejpch.v6i4.1568.

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Background, rationale and objectives: The assessment of medication management ability in the elderly can be performed using specific tools, such as the Self-Medication Assessment Tool, which considers real and simulated regimens. The objective of this study was to perform the linguistic and cultural adaptation of the Self-Medication Assessment Tool to European Portuguese and determine its psychometric properties.Methods: The adaptation commenced with the translation/back translation cycle completed by 4 independent bilingual experts. The cultural component was accomplished through an external
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Frazier, Kyle R., and Kimberly C. McKeirnan. "Medication Management; Hypertensive Crisis During a Home Visit." Senior Care Pharmacist 35, no. 2 (2020): 75–80. http://dx.doi.org/10.4140/tcp.n.2020.75.

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This report describes a case of hypertensive crisis identified by two pharmacists conducting a patient home visit. A 72-year-old woman living in a rural town in Eastern Washington state was referred for a pharmacist home visit by her care coordinator, who had concerns of possible medication-related issues. The patient had a history of type 2 diabetes mellitus, hypertension, ischemic stroke, heart failure with preserved ejection fraction, hypothyroidism, and unspecified back pain. This patient also experienced additional challenges resulting from living in a rural and medically underserved comm
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Khayyat, Sarah M., Ruba S. Azfr Ali, Hanadi H. Alrammaal, et al. "Predictors of medication regimen complexity and its impact on hemoglobin a1c in type 2 diabetes patients: a retrospective analysis in ambulatory care in Makkah City." Annals of Saudi Medicine 44, no. 5 (2024): 296–305. http://dx.doi.org/10.5144/0256-4947.2024.296.

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is a widespread chronic disease that poses a significant management challenge due to the complexity of the associated medication regimens, which can have a considerable impact on patient outcomes. OBJECTIVES: Explore the complexity level of diabetes medications among patients with T2DM and to identify the predictors of medication regimen complexity (MRC) and its correlation with hemoglobin A1C (HbA1c) levels. DESIGN: Retrospective, cross-sectional study SETTING: An ambulatory care setting of a tertiary hospital in Makkah City, Saudi Arabia PATIENTS A
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Aston, Jeff, Keith Wilson, and David Terry. "P016 Parent/carer intended non- adherence to their child’s medication regimen." Archives of Disease in Childhood 104, no. 7 (2019): e2.19-e2. http://dx.doi.org/10.1136/archdischild-2019-nppc.26.

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AimTo identify intended non-adherence reported by parents/carers of children/young people taking long-term medication.MethodsA 10 question postal survey was sent to 180 parents of patients receiving medication via homecare at a tertiary paediatric hospital with a single repeat mailing. Demographic details collected were age, current prescribed medication and duration. Participants were asked about changes that they had made to their child’s medication without consulting a healthcare professional. They were asked about delaying/not starting new medication, compliance with medication instruction
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Sumida, C., S. Norman, A. Weakley, and M. Schmitter-Edgecombe. "A - 23The Effect of Medication Regimen Complexity Index on Medication Management Performance-Based Assessments." Archives of Clinical Neuropsychology 33, no. 6 (2018): 703–94. http://dx.doi.org/10.1093/arclin/acy061.23.

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Schillinger, Dean, Eddie Machtinger, Frances Wang, Maytrella Rodriguez, and Andrew Bindman. "Preventing Medication Errors in Ambulatory Care: The Importance of Establishing Regimen Concordance." Journal of Medical Regulation 93, no. 3 (2007): 20–28. http://dx.doi.org/10.30770/2572-1852-93.3.20.

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ABSTRACT Objective: Miscommunication between patients and providers can have serious consequences—especially where medications are concerned. Because oral anticoagulants are associated with preventable adverse events at disproportionately high rates, we used the model of anticoagulant care to examine the extent to which regimen discordance between patient and provider contributes to unsafe medication management. Methods: We performed a study among 220 long-term users of warfarin in an anticoagulation clinic to characterize the importance of two medication assessment components. We measured (1)
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Serper, Marina, Alexander Burdzy, Douglas E. Schaubel, et al. "Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial." BMJ Open 13, no. 9 (2023): e075172. http://dx.doi.org/10.1136/bmjopen-2023-075172.

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Background and aimsLiver transplantation is a life-saving procedure for end-stage liver disease. However, post-transplant medication regimens are complex and non-adherence is common. Post-transplant medication non-adherence is associated with graft rejection, which can have long-term adverse consequences. Transplant centres are equipped with clinical staff that monitor patients post-transplant; however, digital health tools and proactive immunosuppression adherence monitoring has potential to improve outcomes.Methods and analysisThis is a patient-randomised prospective clinical trial at three
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Strickland, PharmD, BCPS, Jennifer M., Angela Huskey, PharmD, and David B. Brushwood, RPh, JD. "Pharmacist-physician collaboration in pain management practice." Journal of Opioid Management 3, no. 6 (2007): 295. http://dx.doi.org/10.5055/jom.2007.0017.

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Pain is one of the most common reasons patients seek out healthcare and management typically requires complex medication regimens. Pharmacists have become increasingly more involved in pain management. Historically, pharmacists and physicians have often had adversarial relationships because of regulatory influence. However, as medication experts, pharmacists can play a key role in optimizing outcomes in the management of pain and can be critical to the success of the medication regimen. Numerous opportunities for collaboration exist for pharmacists and physicians in various settings. One examp
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Hamilton, William G., Jeanine M. Gargiulo, and Nancy L. Parks. "Using pharmacogenetics to structure individual pain management protocols in total knee arthroplasty." Bone & Joint Journal 102-B, no. 6_Supple_A (2020): 73–78. http://dx.doi.org/10.1302/0301-620x.102b6.bjj-2019-1539.r1.

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Aims The purpose of this study was to use pharmacogenetics to determine the frequency of genetic variants in our total knee arthroplasty (TKA) patients that could affect postoperative pain medications. Pharmacogenetic testing evaluates patient DNA to determine if a drug is expected to have a normal clinical effect, heightened effect, or no effect at all on the patient. It also predicts whether patients are likely to experience side effects from medicine. We further sought to determine if changing the multimodal programme based on these results would improve pain control or reduce side effects.
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Jensen, Christine, Lauren Burnette, and Faika Zanjani. "Medication Management and the Role of the Geriatric Pharmacist in Interdisciplinary Care Teams." Innovation in Aging 5, Supplement_1 (2021): 575. http://dx.doi.org/10.1093/geroni/igab046.2206.

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Abstract Among adults 65 and older, 30% are taking at least five medications to treat acute and chronic health conditions (Gavin, 2020). As the number of medications increases, the more complex the regimen tends to be, which increases risks with proper management and unwanted side effects. Our interdisciplinary geriatric assessment team has been conducting medication reviews for individuals living with dementia, where geriatric pharmacists meet with these individuals and their family caregiver. These sessions build a trusting relationship, where older adults are able to receive education about
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Wang, Dan, Ting Jiang, Lingli Zheng, et al. "Analgesic treatment for refractory cancer pain caused by gastric cancer bone metastasis: A case report and literature review." Medicine 103, no. 28 (2024): e38851. http://dx.doi.org/10.1097/md.0000000000038851.

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Rationale: Patients with bone metastasis-associated cancer pain often experience a complex mix of pain types. Consequently, the use of multimodal combination therapy is essential. While monitoring for common adverse reactions in pain treatment, it is also crucial to be vigilant for the rare but serious serotonin syndrome. Patient concerns: A 53-year-old female with metastatic gastric cancer was hospitalized due to severe, uncontrolled thoracic and cervical pain. During the titration of her cancer pain medication, she developed serotonin syndrome. Diagnoses: He was diagnosed with refractory can
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Samajdar, Shambo Samrat, Sougata Sarkar, Shravan Venkatraman, Amit Kumar Dey, Banshi Saboo, and Shashank R. Joshi. "Navigating the perils of polypharmacy: A clinical pharmacology case study from elderly patient care." National Journal of Pharmacology and Therapeutics 2, no. 2 (2024): 116–18. http://dx.doi.org/10.4103/njpt.njpt_34_24.

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Abstract: Polypharmacy is increasingly prevalent among elderly populations due to multimorbidity and the expansion of pharmaceutical options. This case report explores the adverse effects of polypharmacy in an elderly patient, emphasizing the importance of appropriate medication management and the role of clinical pharmacologists. A 78-year-old male with multiple comorbidities was discharged with a complex medication regimen from a hospital in West Bengal. Within 5 days, he experienced severe complications including QT prolongation and a significant fall resulting in a femur fracture. These ev
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Bernhard, Gerda, Dominik Ose, Ines Baudendistel, et al. "Understanding Challenges, Strategies, and the Role of Support Networks in Medication Self-management Among Patients With Type 2 Diabetes." Diabetes Educator 43, no. 2 (2017): 190–205. http://dx.doi.org/10.1177/0145721717697243.

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Purpose The purpose of this qualitative study was to investigate the challenges and strategies of patients with type 2 diabetes mellitus (T2DM) regarding daily management of their medication regimen focusing on the role of their support networks. Methods A purposeful sample of 25 patients with T2DM was recruited from local self-help groups, general practitioner practices, and a university hospital in southwestern Germany. Four semi-structured focus groups were conducted to identify the challenges patients experienced, the strategies they used, and their collaboration with support networks to a
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Parus Saleem, Muhammad Sikandar Arain, Sidra-tul-Muntaha, et al. "Medicine Compliance Among Hypertensive Patients with Known Diabetes Mellitus in Sindh, Pakistan." Journal of Health and Rehabilitation Research 4, no. 3 (2024): 1–5. http://dx.doi.org/10.61919/jhrr.v4i3.1528.

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Background: Hypertension and diabetes mellitus are prevalent chronic conditions, requiring long-term medication adherence for effective management. Non-compliance can lead to severe health complications and increased healthcare costs.Objective: To evaluate medication compliance among hypertensive patients with known diabetes mellitus in Sindh, Pakistan, and identify key factors contributing to non-compliance.Methods: This cross-sectional study included 381 participants from various cities in Sindh, selected through convenience sampling. Data were collected using a structured questionnaire cove
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Mason, Julie, Hannah Vallance, Sarah Pontefract, and Jamie J. Coleman. "Safe prescribing in general dental practice – challenges and solutions." Dental Update 46, no. 9 (2019): 828–35. http://dx.doi.org/10.12968/denu.2019.46.9.828.

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All dental practitioners will treat patients who take medicines. An ageing population, combined with improved management of patients with multiple long-term co-morbidities, has seen a rise in complex medication regimens. Healthcare specialization, a widening drug market and better access to medicines has also contributed to more patients taking multiple medicines for conditions, often managed by a variety of specialists. Whether these medicines are prescribed or bought over-the-counter, dental practitioners must understand the implications that these treatment regimens can have on dental care.
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Swanlund, Susan L. "Medication Regimen Complexity: A Factor in Successful Self-Management of Medications by Community-Dwelling Older Adults?" Geriatric Nursing 29, no. 2 (2008): 115. http://dx.doi.org/10.1016/j.gerinurse.2008.02.007.

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Manalel, Jasmine, Jennifer Kaufman, Ethan Fusaris, Arlene Correa, Jerome Ernst, and Mark Brennan-Ing. "AGING WITH HIV: ASSOCIATION OF ART REGIMEN AND ADHERENCE TO VIRAL SUPPRESSION." Innovation in Aging 7, Supplement_1 (2023): 907. http://dx.doi.org/10.1093/geroni/igad104.2917.

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Abstract Adherence to antiretroviral therapy (ART) is essential to effective management of HIV among an increasing population of older adults. Newer ART regimens are more “forgiving” of poor adherence allowing for viral suppression at lower adherence levels (i.e., < 90%). This is especially promising for some older adults who may struggle with adherence due to high rates of multimorbidity and polypharmacy. We aimed to determine how ART forgiveness varies depending on ART type and adherence. Data came from 2017-2019 claims and clinical records of 1,044 HIV-positive members of a Medicaid
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Patel, Tejal, Aidan McDougall, Jessica Ivo, et al. "Development and Content Validation of an Instrument to Measure Medication Self-Management in Older Adults." Pharmacy 9, no. 2 (2021): 78. http://dx.doi.org/10.3390/pharmacy9020078.

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Background: For older adults, the capacity to self-manage medications may be limited by several factors. However, currently available tools do not permit a comprehensive assessment of such limitations. The Domain Specific Limitation in Medication Management Capacity (DSL-MMC) was developed to address this need. This study aimed to establish the face and content validity of the DSL-MMC. Methods: The DSL-MMC tool consisted of 4 domains and 12 sub-domains with 42 items including: 1. physical abilities (vision, dexterity, hearing); 2. cognition (comprehension, memory, executive functioning); 3. me
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Hennes, Emily R., Michael Reed, Mary Mably, et al. "Implementation of a chemotherapy stewardship process." American Journal of Health-System Pharmacy 77, no. 15 (2020): 1243–48. http://dx.doi.org/10.1093/ajhp/zxaa157.

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Abstract Purpose To design and implement a chemotherapy stewardship process to optimize the location of chemotherapy administration in an effort to decrease the number of inappropriate inpatient anticancer regimen administrations and decrease institutional costs associated with inpatient administration. Summary As the costs of anticancer agents continue to rise, it is crucial that multidisciplinary efforts are aimed at managing anticancer medication utilization; this is especially important for high-cost medications, medications whose use requires increased monitoring due to safety concerns, a
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Sluggett, Janet K., Georgina A. Hughes, Choon Ean Ooi, et al. "Process Evaluation of the SImplification of Medications Prescribed to Long-tErm Care Residents (SIMPLER) Cluster Randomized Controlled Trial: A Mixed Methods Study." International Journal of Environmental Research and Public Health 18, no. 11 (2021): 5778. http://dx.doi.org/10.3390/ijerph18115778.

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Complex medication regimens are highly prevalent, burdensome for residents and staff, and associated with poor health outcomes in residential aged care facilities (RACFs). The SIMPLER study was a non-blinded, matched-pair, cluster randomized controlled trial in eight Australian RACFs that investigated the one-off application of a structured 5-step implicit process to simplify medication regimens. The aim of this study was to explore the processes underpinning study implementation and uptake of the medication simplification intervention. A mixed methods process evaluation with an explanatory de
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S.Sharmila, Kumari, Jayasree V., V. Padmaja K., and Sai Navya Vaddeboyina. "Comparative Study of the Standard Pritchard Regimen and Low Dose Dhaka Regimen of Magnesium Sulphate in the Management of Severe Preeclampsia and Eclampsia." International Journal of Toxicological and Pharmacological Research 14, no. 4 (2024): 6–13. https://doi.org/10.5281/zenodo.12790814.

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<strong>Background:</strong>&nbsp;Pre eclampsia and eclampsia are responsible for more than 50,000 maternal fatalities worldwide. Controlling convulsions is the first rule in the treatment of eclampsia. Magnesium sulphate is the anticonvulsant medication of choice for both preventing and treating eclampsia, but its toxicities are dose-related, which is a serious issue. In many low-income nations, the medicine is only sometimes used due to unwarranted concern over these risks. Reducing the toxicity of magnesium sulphate without sacrificing its effectiveness in preventing seizures and reducing m
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Rostami, Fatemeh, Malihe Babahaji, Fateme Sheikhnejad, and Vahideh Karimi. "The effect of the continuous care model on the adherence to the medication regimen of patients hospitalized in the psychiatric ward: A quasi-experimental study." Journal of Nursing Advances in Clinical Sciences 1, no. 2 (2024): 85–90. http://dx.doi.org/10.32598/jnacs.2405.1025.

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The present study aims to determine the effect of the continuous care model on the adherence to the medication regimen of patients hospitalized in the psychiatric ward. This quasi-experimental research was carried out on a sample of 46 patients who were admitted to the psychiatric ward. The data collection tools employed in this research included a demographic questionnaire and an 8-item MMAS-8 medication adherence questionnaire. Before the intervention, the adherence rate to the medication regimen was 2.82 (SD=1.62) in the intervention group and 3.20 (SD=2.50) in the control group. The Mann-W
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Arshpreet, Kaur. "Evaluating the Effectiveness of Ohtuvayre Regimen Over Albuterol in COPD Management." International Journal of Clinical Science and Medical Research 05, no. 03 (2025): 54–56. https://doi.org/10.5281/zenodo.14959107.

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ABSTRACT : One of the main causes of morbidity and poor health worldwide is Chronic Obstructive Pulmonary Disease (COPD) (World Health Organisation, 2024.). Over the last two decades, inhalation treatments had not advanced very much. Still, the U.S. Food and Drug Administration (FDA)'s recent approval of Ohtuvayre (ensifentrine) has brought a first-inclass inhalation medication combining bronchodilator and anti-inflammatory properties via dual inhibition of phosphodiesterase enzymes PDE3 and PDE4. Many trials have confirmed the usage of the new medicine by showing considerable increases in for
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Walsh, Katherine E. "The Relationship Between Leadership Practices and a Medication Safety Regimen." Nursing Administration Quarterly 28, no. 4 (2004): 306–8. http://dx.doi.org/10.1097/00006216-200410000-00014.

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BHADORIYA, ABHILASHA, and TRUPTI SHUKLA. "A CONCISE REVIEW ON SPANSULES: A NEW METHOD OF DRUG DELIVERY." Current Research in Pharmaceutical Sciences 13, no. 1 (2023): 21–26. http://dx.doi.org/10.24092/crps.2023.130102.

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Spansules are considered as an Advanced Drug Delivery System because they allow for controlled and sustained release of medication over an extended period of time. This type of delivery system can provide a constant plasma drug concentration over a wide range of time, which can improve treatment outcomes and reduce the risk of side effects. In addition to providing sustained release, Spansules can also be used to deliver multiple drugs in a single dosage form. The multi-drug regimen capability of Spansules is also beneficial, as it allows for the delivery of multiple drugs in a single dosage f
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Hingmire, Sachin, and Nirmal Raut. "Open-label observational study to assess the efficacy and safety of aprepitant for chemotherapy-induced nausea and vomiting prophylaxis in Indian patients receiving chemotherapy with highly emetogenic chemotherapy/moderately emetogenic chemotherapy regimens." South Asian Journal of Cancer 04, no. 01 (2015): 007–10. http://dx.doi.org/10.4103/2278-330x.149923.

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Abstract Context: Currently, there is limited data on the prevention of chemotherapy-induced nausea and vomiting (CINV) in Indian population with aprepitant containing regimens. Aims: The aim was to assess the Efficacy and Safety of Aprepitant for the prevention of nausea and vomiting associated with highly emetogenic chemotherapy/moderately emetogenic chemotherapy (HEC/MEC) regimens. Settings and Design: Investigator initiated, multicentric, open-label, prospective, noncomparative, observational trial. Subjects and Methods: Triple drug regimen with aprepitant, palonosetron, and dexamethasaone
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Wisseh, Cheryl, Edward Adinkrah, Linda Opara, et al. "Associations between Diabetes-Specific Medication Regimen Complexity and Cardiometabolic Outcomes among Underserved Non-Hispanic Black Adults Living with Type 2 Diabetes Mellitus." Pharmacy 12, no. 3 (2024): 83. http://dx.doi.org/10.3390/pharmacy12030083.

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Type 2 diabetes mellitus (T2DM) management and glycemic control in underserved non-Hispanic Black adults presents with multifaceted challenges: balancing the optimal complexity of antihyperglycemic medications prescribed, limited medication access due to socioeconomic status, medication nonadherence, and high prevalence of cardiometabolic comorbidities. This single-center, cross-sectional, retrospective chart analysis evaluated the association of Medication Regimen Complexity (MRC) with cardiometabolic outcomes (glycemic, atherogenic cholesterol, and blood pressure control) among non-Hispanic
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Rahman, A., R. Habib, NB Bhowmik, and A. Haque. "Medication Overuse Headache: A Trap for the Headache Patients." BIRDEM Medical Journal 3, no. 2 (2013): 94–98. http://dx.doi.org/10.3329/birdem.v3i2.17213.

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Medication Overuse Headache (MOH) was previously termed analgesic rebound headache, drug-induced headache, and medication-misuse headache. It is not a primary headache but frequently coexists with primary chronic daily headache. All acute symptomatic medications used to treat headaches have the potential for causing MOH. Highest with opioids, butalbital-containing combination analgesics, and aspirin/ acetaminophen/caffeine combinations. The development is typically preceded by an episodic headache disorder, usually migraine or tension-type headache, that has been treated with frequent and exce
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Alharbi, Noha Awed, and Yahya Abdu Alkhawaji. "Use and Effectiveness of Digital Adherence Tools." Saudi Journal of Medical and Pharmaceutical Sciences 9, no. 03 (2023): 155–62. http://dx.doi.org/10.36348/sjmps.2023.v09i03.003.

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Adherence to (or compliance with) a medication schedule refers to the extent to which individuals take drugs as advised by their medical professionals. Many medical practitioners prefer the term "adherence" over "compliance," as the latter suggests that the patient is merely following orders from their doctor passively and that the treatment regimen is not founded on a therapeutic alliance or partnership between the patient and the provider. Particularly for chronic illnesses, maintaining commitment to a therapy regimen is challenging, which frequently hinders patients from reaping the full ad
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Mathys, Monica. "Pharmacologic management of behavioral and psychological symptoms of major neurocognitive disorder." Mental Health Clinician 8, no. 6 (2018): 284–93. http://dx.doi.org/10.9740/mhc.2018.11.284.

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Abstract Behavioral and psychological symptoms of dementia (BPSD) occur in approximately 80% of patients who receive a diagnosis of major neurocognitive disorder. Nonpharmacologic strategies are the first-line treatment for BPSD. However, psychotropic medications are often necessary when nonpharmacologic methods are not effective in treating symptoms that are distressing or are causing behaviors that are dangerous to the patient or the patient's caregivers. The article provides a review of evidence-based recommendations for the use of antipsychotics, cognitive enhancers, and serotonin reuptake
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Sluggett, Janet Kathleen, Amy Theresa Page, Esa Y. H. Chen, et al. "Protocol for a non-randomised pilot and feasibility study evaluating a multicomponent intervention to simplify medication regimens for people receiving community-based home care services." BMJ Open 9, no. 7 (2019): e025345. http://dx.doi.org/10.1136/bmjopen-2018-025345.

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IntroductionManaging medication regimens is one of the most complex and burdensome tasks performed by older people, and can be prone to errors. People living with dementia may require medication administration assistance from formal and informal caregivers. Simplified medication regimens maintain the same therapeutic intent, but have less complex instructions and administration schedules. This protocol paper outlines a study to determine the feasibility of a multicomponent intervention to simplify medication regimens for people receiving community-based home care services.Methods and analysisT
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Uchimura, Y., K. Omae, K. Waki, H. Fujita, K. Ohe, and M. Hayakawa. "A Smartphone-based Medication Self-management System with Real-time Medication Monitoring." Applied Clinical Informatics 04, no. 01 (2013): 37–52. http://dx.doi.org/10.4338/aci-2012-10-ra-0045.

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SummaryBackground: Most patients cannot remember their entire medication regimen and occasionally forget to take their medication.Objectives: The objective of the study was to design, develop, and demonstrate the feasibility of a new type of medication self-management system using smartphones with real-time medication monitoring.Methods: We designed and developed a smartphone-based medication self-management system (SMSS) based on interviews of 116 patients. The system offered patients two main functions by means of smartphones: (1) storage and provision of an accurate, portable medication his
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Fusick, Adam J., Chemar Davis, Steven Gunther, Cory Klippel, and Gregory Sullivan. "Psychotropic Management in Cotard Syndrome: Case Reports Supporting Dual Medication Management." Case Reports in Psychiatry 2024 (April 9, 2024): 1–5. http://dx.doi.org/10.1155/2024/7630713.

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Cotard syndrome is a rare presentation where patients present with nihilistic thoughts of dying or already being dead. These delusions manifest from either a medical or psychiatric etiology and can be difficult to treat. Recently Couto and Gonçalves purposed that treatment should include an atypical antipsychotic alone or in combination with either a mood stabilizer or antidepressant. Here the authors advocate for a more specific but well-known psychotropic regimen, namely the combination of olanzapine and fluoxetine. We conducted a literature review and of 246 papers identified, only three re
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Patel, Tejal Pareshkumar, Stanley Mwenda Aruyar, and Paul Bundi Karau. "Is There a Role of Lavage in Peritoneal Tuberculosis?" Annals of African Surgery 21, no. 2 (2024): 49–53. http://dx.doi.org/10.4314/aas.v21i2.3.

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Abdominal tuberculosis (TB), an extrapulmonary manifestation of TB, can present with nonspecific symptoms that may resemble an acute surgical abdomen or abdominal malignancy. Peritoneal tuberculosis/TB peritonitis, typically manifests with abdominal pain, abdominal distension (possibly due to ascites), weight loss, and night sweats. We present two cases of peritoneal TB where patients exhibited abdominal distension and weight loss with features suggestive of intestinal obstruction or an abdominal malignancy. They were initially treated with standard anti-TB medication (RHZE regimen), but showe
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Nitish, Kumar, Deo Brijendra, and Kumar Santosh. "Assessment of Drug Compliance using Home Medication Review in Pediatric Population: A Community-Based Study." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 3051–55. https://doi.org/10.5281/zenodo.13830791.

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<strong>Background:&nbsp;</strong>Medication adherence is crucial for managing chronic illnesses in pediatric patients, but adherence rates are often suboptimal, leading to poor health outcomes and increased healthcare costs. Home Medication Reviews (HMRs) have shown potential in improving adherence by providing tailored interventions. The aim of this study was to assess drug compliance in pediatric patients through HMRs in a community-based setting in Saharsa, Bihar, India.&nbsp;<strong>Methods:</strong>&nbsp;The study included 100 pediatric patients with chronic illnesses. Data were collecte
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Slattum, Patricia, and Elvin Price. "Engaging Pharmacists in Interprofessional Programs to Support Older Residents of HUD-Assisted Housing." Innovation in Aging 4, Supplement_1 (2020): 761. http://dx.doi.org/10.1093/geroni/igaa057.2746.

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Abstract Medications are one of the pillar 4Ms of an age-friendly healthcare system. Ensuring that benefits of a medication regimen outweigh the risks and that medications are not contributing to meaningful outcomes such as functional or cognitive decline is a challenge for our healthcare system, particularly for older persons experiencing adverse social determinants of health, health disparities or uncoordinated care. More fully engaging pharmacists in the older person’s health care team is one strategy to improve clinical, humanistic and economic outcomes. This workshop reports findings on m
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Meyer, Kristin S., Jessica Roberts, and Kimberly Sasser Croley. "Part Four: Identifying, Managing, and Preventing Adverse Effects of Diabetes Medications." Senior Care Pharmacist 37, no. 8 (2022): 310–16. http://dx.doi.org/10.4140/tcp.n.2022.310.

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Background An 81-year-old woman with type 2 diabetes, residing in a long-term care facility, has experienced a fall after medication changes, and a few days of irregular eating. Assessment This patient may be experiencing one or more common potential adverse events related to her diabetes medications. There is a need to create individualized treatment goals in this case. Outcome After a revision of treatment goals for hypertension and diabetes, and adjustments to the medication regimen, there have been no subsequent falls and this patient reports that she feels better. Conclusion As the person
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Duncan, Nakia A., Rebecca J. Mahan, and Sarah J. Turner. "Non-opiate pharmacotherapy options for the management of pain in older adults." Mental Health Clinician 5, no. 3 (2015): 91–101. http://dx.doi.org/10.9740/mhc.2015.05.091.

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Abstract Pain is highly prevalent, costly, and disabling in later life, especially when undertreated. In this article, we aim to describe the risks and benefits of non-opioid medication options for the management of pain in adults aged 65 years and older in order to provide additional options in a practitioner's tool box when designing a pain management regimen for an older adult. Non-opiate pharmacologic therapies, such as acetaminophen, nonsteroidal anti-inflammatory drugs, topicals, and antidepressants have an important role in pain management of older adults. When designing a pain regimen,
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Olugbenga, Ijaodola Aremu. "Disease Severity, Health Beliefs, and Medication Adherence among HIV Patients in a Tertiary Hospital Abuja, Nigeria." TEXILA INTERNATIONAL JOURNAL OF PUBLIC HEALTH 9, no. 2 (2021): 85–94. http://dx.doi.org/10.21522/tijph.2013.09.02.art008.

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Anti-Retroviral Therapy (ART) Has Decreased The Mortality And Morbidity Of HIV/AIDS. Several Medicines Are Prescribed For Disease Management; However, Adherence To Long-Term Therapy Remains Poor. Disease Severity And Health Beliefs About Medications Ultimately Influence Adherence To Treatment. There Is A Paucity Of Data With Regard To Disease Severity, Health Beliefs And Medication Adherence Among HIV Patients. The Purpose Of The Study Was To Investigate The Relationship Between Disease Severity, Health Beliefs, And Medication Adherence Among HIV Patients. A Cross-Sectional Descriptive Survey
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