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Journal articles on the topic 'Medicinal Chemistry'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 January 2025

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1

Jawad, ASMAA, Reem Husam Al-Tabra, and Baraa Watheq. "The role of Chemistry in drugs discovery." Al-Kufa University Journal for Biology 16, no. 1 (April 30, 2024): 110–19. https://doi.org/10.36320/ajb/v16.i1.15085.

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The function of the medicinal chemist in drug discovery has significantly evolved over the last 25 years, mostly due to the use of technologies like combinatorial chemistry and structure-based drug design. With a collective experience of over 50 years in medicinal chemistry, covering the last four decades, we will explore this evolving function by drawing on both our own experiences and those of others. Examining this historical viewpoint may provide valuable insights on enhancing the present drug discovery framework by enabling medicinal chemists to reclaim their creative involvement that played a significant part in previous achievements.
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2

Buckle, Derek R., Paul W. Erhardt, C. Robin Ganellin, Toshi Kobayashi, Thomas J. Perun, John Proudfoot, and Joerg Senn-Bilfinger. "Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)." Pure and Applied Chemistry 85, no. 8 (July 31, 2013): 1725–58. http://dx.doi.org/10.1351/pac-rec-12-11-23.

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The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become both integrated and essential terminology for the medicinal chemist. Some of this augmented terminology has been adopted from the many related and interlocked scientific disciplines with which the modern medicinal chemist must be conversant, but many other terms have been introduced to define new concepts and ideas as they have arisen. In this supplementary Glossary, we have attempted to collate and define many of the additional terms that are now considered to be essential components of the medicinal chemist’s expanded repertoire.
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3

DALTON, LOUISA WRAY. "MEDICINAL CHEMISTRY." Chemical & Engineering News Archive 81, no. 25 (June 23, 2003): 53–56. http://dx.doi.org/10.1021/cen-v081n025.p053.

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4

Zhang, Li-he, and Kaixian Chen. "Medicinal chemistry." Drug Discovery Today: Technologies 3, no. 3 (September 2006): 239–40. http://dx.doi.org/10.1016/j.ddtec.2006.09.015.

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5

Peng, Xing, and Meilan Li. "Thoughts on Natural Medicinal Chemistry." Journal of Applied Virology 8, no. 3 (December 8, 2019): 29–34. http://dx.doi.org/10.21092/jav.v8i3.111.

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Natural products, with novel structures and broad biological activities, are the main sources of drug lead compounds. Over years, natural products have made outstanding contributions to the fight against viruses. Herein, the article briefly shares some thoughts about natural medicinal chemistry as references for chemists and biologists.
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6

Phillip Bowen, J., and Haizhen A. Zhong. "Perspectives in Medicinal Chemistry: The Evolution of Medicinal Chemistry." Current Topics in Medicinal Chemistry 16, no. 9 (November 25, 2015): 897–98. http://dx.doi.org/10.2174/1568026616999151029114013.

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7

Alberto, Roger. "Medicinal Inorganic Chemistry." CHIMIA International Journal for Chemistry 61, no. 11 (November 28, 2007): 691. http://dx.doi.org/10.2533/chimia.2007.691.

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8

Schneider, Gisbert. "Computational medicinal chemistry." Future Medicinal Chemistry 3, no. 4 (March 2011): 393–94. http://dx.doi.org/10.4155/fmc.11.10.

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9

DANISHEFSKY, SAMUEL J. "TACKLING MEDICINAL CHEMISTRY." Chemical & Engineering News 85, no. 38 (September 17, 2007): 41–42. http://dx.doi.org/10.1021/cen-v085n038.p041.

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10

Copeland, Robert A. "Epigenetic Medicinal Chemistry." ACS Medicinal Chemistry Letters 7, no. 2 (December 10, 2015): 124–27. http://dx.doi.org/10.1021/acsmedchemlett.5b00462.

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11

Candlish, John. "Modern medicinal chemistry." Biochemical Education 23, no. 1 (January 1995): 44. http://dx.doi.org/10.1016/0307-4412(95)90197-3.

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12

Gibbons, William A. "Comprehensive medicinal chemistry." Trends in Biochemical Sciences 16 (January 1991): 237–38. http://dx.doi.org/10.1016/0968-0004(91)90093-b.

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13

Stahl, Martin, and Jürgen Bajorath. "Computational Medicinal Chemistry." Journal of Medicinal Chemistry 54, no. 1 (January 13, 2011): 1–2. http://dx.doi.org/10.1021/jm1013055.

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14

Timmerman, H., A. Bast, H. Van der Goot, N. P. E. Vermeulen, and F. J. Zeelen. "Comprehensive medicinal chemistry." Trends in Pharmacological Sciences 12 (January 1991): 167–68. http://dx.doi.org/10.1016/0165-6147(91)90535-z.

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15

Stemp, G. "Modern Medicinal Chemistry." Trends in Pharmacological Sciences 15, no. 9 (September 1994): 350–51. http://dx.doi.org/10.1016/0165-6147(94)90033-7.

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16

Koppitz, Marcus, and Knut Eis. "Automated medicinal chemistry." Drug Discovery Today 11, no. 11-12 (June 2006): 561–68. http://dx.doi.org/10.1016/j.drudis.2006.04.005.

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17

Peralta, David. "Open Medicinal Chemistry." ChemMedChem 14, no. 1 (December 28, 2018): 4–7. http://dx.doi.org/10.1002/cmdc.201800797.

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18

Almeida, M. O., V. G. Maltarollo, R. A. Toledo, H. Shim, M. C. Santos, and K. M. Honorio. "Medicinal Electrochemistry: Integration of Electrochemistry, Medicinal Chemistry and Computational Chemistry." Current Medicinal Chemistry 21, no. 20 (May 31, 2014): 2266–75. http://dx.doi.org/10.2174/0929867321666140217120655.

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19

Gooch, Eugene. "Medicinal Chemistry - An Introduction; Fundamentals of Medicinal Chemistry (Gareth Thomas)." Journal of Chemical Education 81, no. 9 (September 2004): 1271. http://dx.doi.org/10.1021/ed081p1271.

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20

Mistry, Shailesh N., Pascal Marchand, and Barrie Kellam. "27th Annual GP2A Medicinal Chemistry Conference." Pharmaceuticals 12, no. 4 (December 6, 2019): 179. http://dx.doi.org/10.3390/ph12040179.

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The 27th annual GP2A (Groupement des Pharmacochimistes de l′Arc Atlantique/Group of Medicinal Chemists in the Atlantic Arc) conference took place from 21 to 23 August 2019, at the East Midlands Conference Centre (University Park, Nottingham, United Kingdom) and was hosted by the Division of Biomolecular Science and Medicinal Chemistry (BSMC), within the School of Pharmacy at the University of Nottingham. The event brought together an international delegation of researchers with interests in medicinal chemistry and interfacing disciplines. In addition, a pre-conference workshop provided an opportunity for younger researchers to develop their theoretical knowledge in quantitative pharmacology. Abstracts of presentations by the 14 invited speakers and 6 young researchers, in addition to 41 posters, are included in this report.
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21

De Filippis, Barbara, Alice Della Valle, Alessandra Ammazzalorso, Cristina Maccallini, Giuseppe Tesse, Rosa Amoroso, Adriano Mollica, and Letizia Giampietro. "Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry." Molecules 29, no. 24 (December 12, 2024): 5872. https://doi.org/10.3390/molecules29245872.

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The discovery of a multi-target scaffold in medicinal chemistry is an important goal for the development of new drugs with different biological effects. Azobenzene is one of the frameworks in medicinal chemistry used for its simple synthetic methods and for the possibility to obtain a great variety of derivatives by simple chemical modifications or substitutions. Phenyldiazenyl-containing compounds show a wide spectrum of pharmacological activities, such as antimicrobial, anti-inflammatory, anti-neurodegenerative, anti-cancer, and anti-enzymatic. The aim of this review is to highlight the importance of azobenzene as a scaffold in medicinal chemistry, with particular attention to the chemical modifications and structure–activity relationships (SARs). This review emphasizes the main therapeutic applications of phenyldiazenyl derivatives, with a particular focus on structural modification and its influence on activity, with the aim of inspiring medicinal chemists to obtain new, increasingly powerful azobenzenes useful in therapy.
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22

Dallemagne, Patrick, Christophe Rochais, Pascal Marchand, and Thierry Besson. "26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie." Pharmaceuticals 12, no. 2 (May 16, 2019): 73. http://dx.doi.org/10.3390/ph12020073.

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As a joint meeting, the 26th Medicinal Chemistry Conference of GP2A and 32nd Journées Franco-Belges de Pharmacochimie took place between 13th and 15th June at Asnelles sur Mer (Normandie, France), providing a unique opportunity for a wide group of European medicinal chemists to engage. Topics included chemical tools for medicinal chemistry, protein-protein interactions, epigenetics, natural product-inspired molecules, computer-aided drug design, and new strategies for the design and development of drugs. Abstracts of invited lectures, proffered young researcher communications, flash communications and posters presented during the meeting are collected in this report.
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23

Singh, Gyanendra, and R. K Saxena. "Chemistry and Medicinal Properties of Hymenocallis littoralis." International Journal of Science and Research (IJSR) 6, no. 11 (November 5, 2017): 1327–29. http://dx.doi.org/10.21275/art20178293.

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24

Mancini, Ross S., Christopher J. Barden, Donald F. Weaver, and Mark A. Reed. "Furazans in Medicinal Chemistry." Journal of Medicinal Chemistry 64, no. 4 (February 11, 2021): 1786–815. http://dx.doi.org/10.1021/acs.jmedchem.0c01901.

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25

Jampilek, Josef. "Heterocycles in Medicinal Chemistry." Molecules 24, no. 21 (October 25, 2019): 3839. http://dx.doi.org/10.3390/molecules24213839.

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Heteroatoms constitute a very common fragment of a number of active pharmaceutical ingredients as well as excipients; from the point of view of significance, it is all the same if these are isosterically/bioisosterically replaced carbons/carbon substructures in aliphatic structures or real heterocycles [...]
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26

Zhou, Guo-Ping, and Wei-Zhu Zhong. "Perspectives in Medicinal Chemistry:." Current Topics in Medicinal Chemistry 16, no. 4 (October 14, 2015): 381–82. http://dx.doi.org/10.2174/156802661604151014114030.

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27

N. Mikhailov, Sergey, Luciana Scotti, Rajeev K. Singla, and Marcus T. Scotti. "Perspectives in Medicinal Chemistry." Current Topics in Medicinal Chemistry 16, no. 25 (August 16, 2016): 2725–26. http://dx.doi.org/10.2174/156802661625160816180839.

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28

Niwayama, Satomi. "Proteomics in Medicinal Chemistry." Mini-Reviews in Medicinal Chemistry 6, no. 2 (February 1, 2006): 241–46. http://dx.doi.org/10.2174/138955706775476000.

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29

Alcazar, Jesus, Gaston Diels, and Bruno Schoentjes. "Microwave Assisted Medicinal Chemistry." Mini-Reviews in Medicinal Chemistry 7, no. 4 (April 1, 2007): 345–69. http://dx.doi.org/10.2174/138955707780363846.

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30

Zhou, Guo-Ping, and Wei-Zhu Zhong. "Perspectives in Medicinal Chemistry." Current Topics in Medicinal Chemistry 16, no. 999 (October 12, 2015): 1–2. http://dx.doi.org/10.2174/1568026616999151012120650.

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31

Mikhailov, Sergey, Luciana Scotti, Rajeev Singla, and Marcus Scotti. "Perspectives in Medicinal Chemistry." Current Topics in Medicinal Chemistry 16, no. 999 (May 10, 2016): 1–2. http://dx.doi.org/10.2174/1568026616999160510121240.

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32

Lauritano, Dorina. "Perspective in Medicinal Chemistry." Current Topics in Medicinal Chemistry 18, no. 23 (January 10, 2019): 2000–2001. http://dx.doi.org/10.2174/156802661823190110112258.

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33

Vicennati, Paola, Antonella Giuliano, Giancarlo Ortaggi, and Andrea Masotti. "Polyethylenimine In Medicinal Chemistry." Current Medicinal Chemistry 15, no. 27 (November 1, 2008): 2826–39. http://dx.doi.org/10.2174/092986708786242778.

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34

Massarotti, Alberto, Francesca Brunelli, Silvio Aprile, Mariateresa Giustiniano, and Gian Cesare Tron. "Medicinal Chemistry of Isocyanides." Chemical Reviews 121, no. 17 (July 1, 2021): 10742–88. http://dx.doi.org/10.1021/acs.chemrev.1c00143.

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35

Reader, John. "Automation in Medicinal Chemistry." Current Topics in Medicinal Chemistry 4, no. 7 (March 1, 2004): 671–86. http://dx.doi.org/10.2174/1568026043451069.

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36

Oliveri, Valentina, and Graziella Vecchio. "Metallocyclodextrins in medicinal chemistry." Future Medicinal Chemistry 10, no. 6 (March 2018): 663–77. http://dx.doi.org/10.4155/fmc-2017-0249.

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37

Satyanarayanajois, Seetharama D., and Ronald A. Hill. "Medicinal chemistry for 2020." Future Medicinal Chemistry 3, no. 14 (October 2011): 1765–86. http://dx.doi.org/10.4155/fmc.11.135.

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38

Dutertre, Sébastien. "Venomics in medicinal chemistry." Future Medicinal Chemistry 6, no. 15 (October 2014): 1609–10. http://dx.doi.org/10.4155/fmc.14.117.

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39

Diaz, L., and A. Delgado. "Medicinal Chemistry of Aminocyclitols." Current Medicinal Chemistry 17, no. 22 (August 1, 2010): 2393–418. http://dx.doi.org/10.2174/092986710791698512.

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40

Hergenrother, Paul J. "Medicinal Chemistry - An Introduction." Synthesis 2004, no. 13 (2004): 2248. http://dx.doi.org/10.1055/s-2004-832295.

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41

Coats, Eugene A. "Book Review: Medicinal Chemistry." Drug Intelligence & Clinical Pharmacy 19, no. 9 (September 1985): 684. http://dx.doi.org/10.1177/106002808501900925.

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42

Reekie, Tristan A., Craig M. Williams, Louis M. Rendina, and Michael Kassiou. "Cubanes in Medicinal Chemistry." Journal of Medicinal Chemistry 62, no. 3 (August 23, 2018): 1078–95. http://dx.doi.org/10.1021/acs.jmedchem.8b00888.

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43

Liotta, Dennis. "Innovations in Medicinal Chemistry." ACS Medicinal Chemistry Letters 7, no. 7 (July 14, 2016): 656–57. http://dx.doi.org/10.1021/acsmedchemlett.6b00250.

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44

MULLIN, RICK. "CHALLENGES FOR MEDICINAL CHEMISTRY." Chemical & Engineering News 81, no. 42 (October 20, 2003): 18. http://dx.doi.org/10.1021/cen-v081n042.p018.

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45

Orvig, Chris, and Michael J. Abrams. "Medicinal Inorganic Chemistry: Introduction." Chemical Reviews 99, no. 9 (September 1999): 2201–4. http://dx.doi.org/10.1021/cr980419w.

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46

Evered, Derek F. "Trends in medicinal chemistry." Biochemical Education 16, no. 2 (April 1988): 117. http://dx.doi.org/10.1016/0307-4412(88)90103-3.

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47

Cushman, SY. "Topics in Medicinal Chemistry." Biochemical Education 17, no. 1 (January 1989): 53. http://dx.doi.org/10.1016/0307-4412(89)90080-0.

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48

Ostrovskii, V. A., R. E. Trifonov, and E. A. Popova. "Medicinal chemistry of tetrazoles." Russian Chemical Bulletin 61, no. 4 (April 2012): 768–80. http://dx.doi.org/10.1007/s11172-012-0108-4.

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49

Kalman, ThomasI. "Perspectives in medicinal chemistry." Journal of Molecular Graphics 12, no. 3 (September 1994): 235. http://dx.doi.org/10.1016/0263-7855(94)80094-4.

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50

Wess, Günther. "Challenges for medicinal chemistry." Drug Discovery Today 1, no. 12 (December 1996): 529–32. http://dx.doi.org/10.1016/s1359-6446(96)10047-7.

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