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Relevant bibliographies by topics / Medicinal maintenance / Dissertations / Theses

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Dissertations / Theses on the topic 'Medicinal maintenance'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Barnett, William Halbert. "Duty Cycle Maintenance in an Artificial Neuron." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/phy_astr_theses/7.

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Neuroprosthetics is at the intersection of neuroscience, biomedical engineering, and physics. A biocompatible neuroprosthesis contains artificial neurons exhibiting biophysically plausible dynamics. Hybrid systems analysis could be used to prototype such artificial neurons. Biohybrid systems are composed of artificial and living neurons coupled via real-time computing and dynamic clamp. Model neurons must be thoroughly tested before coupled with a living cell. We use bifurcation theory to identify hazardous regimes of activity that may compromise biocompatibility and to identify control strate

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2

Blackwelder, Reid B. "Maintenance of Certification." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etsu-works/6914.

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3

Muchemi, Gerald K. M. "Baboons as maintenance hosts of human schistosomiasis in Kenya." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317139.

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4

Chambers, Emma Louise. "Regulation of follicle growth initiation and maintenance in the mammalian ovary." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275532.

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5

Tam, Nicholas. "The maintenance of Body Fluid Homestasis during exercise when drinking ad Libitum." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/2769.

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The prescription of an optimal fluid intake during exercise has been a controversial subject in sports science over the past decade. Only recently has it evolved from 'blanket' prescriptions to more individualised recommendations. Currently the American College of Sports Medicine (ACSM) advise that sufficient fluid should be drunk in order to ensure that body mass (BM) loss does not exceed >2% of starting BM in order to avoid exercise-associated medical complications. Historically BM changes have been used as a surrogate for fluid loss during exercise. It would be helpful to accurately dete

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6

Steere, Jane Amanda. "The role of anxiety in the maintenance and treatment of bulimia nervosa." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291962.

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7

Ilieva, Antoaneta. "Maintenance of pancreatic islet cell mass and intercellular communications." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27347.

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The purpose of this study was to determine whether pancreatic ductal epithelium has trophic effects on the islets of Langerhans, and how this intercellular communication might be mediated. Islets and ducts were isolated from hamster pancreata. Islets were purified on a bovine serum albumin gradient. Primary duct cultures were passaged twice for cell purification. Duct-conditioned medium (DCM) was collected from duct cultures passaged twice. The islets were allocated to three experimental groups: (1) 100 islets alone; (2) 100 islets + 80 tertiary ducts and (3) 100 islets in 25% DCM. All tissues

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8

Peters, Jillian. "Influential factors in the development and maintenance of eating disorders." Thesis, University of Warwick, 2004. http://wrap.warwick.ac.uk/1218/.

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This thesis examined influential factors in the development and maintenance of eating disorders. The first chapter investigated homosexuality as a predisposing factor in the development of anorexia and bulimia nervosa in males by considering the published literature on this subject. The implications of the role of homosexual culture in the treatment of males with eating disorders are examined. The main study used techniques from grounded theory to examine the subjective experiences of women with anorexia and bulimia nervosa regarding the influence of media in the development and maintenance of

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9

Wentz, Kerstin. "Fibromyalgia and self-regulatory patterns : development, maintenance or recovery in women." Doctoral thesis, Göteborg : Deptartment of Psychology, Göteborg University, 2005. http://hdl.handle.net/2077/107.

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10

Elder, Charles, Christina Gullion, Lynn DeBar, et al. "Randomized trial of tapas acupressure technique for weight loss maintenance." BioMed Central, 2012. http://hdl.handle.net/10150/610364.

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BACKGROUND:Obesity is an urgent public health problem, yet only a few clinical trials have systematically tested the efficacy of long-term weight-loss maintenance interventions. This randomized clinical trial tested the efficacy of a novel mind and body technique for weight-loss maintenance.METHODS:Participants were obese adults who had completed a six-month behavioral weight-loss program prior to randomization. Those who successfully lost weight were randomized into either an experimental weight-loss maintenance intervention, Tapas Acupressure Technique (TAT(R)), or a control intervention com

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11

Rushbrook, Sophie Catherine. "Post-event processing : its role in the maintenance of social phobia and social anxiety." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273900.

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12

Spanos, Dimitrios. "Weight loss and weight maintenance interventions for adults with intellectual disabilities." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4562/.

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Background: The prevalence of obesity is higher in adults with intellectual disabilities (ID) than in the general population, with increased rates of secondary health risks and increased mortality rates. Multi-component weight loss interventions have been advocated by current UK clinical guidelines for all adults without ID. Such interventions incorporate dietary changes that produce an energy deficit, increased levels of physical activity and the use of behavioural approaches to promote and sustain changes in physical activity and dietary patterns, followed by a weight maintenance interventio

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13

Hickman, Carrie J. L. "Weight Loss Surgery Maintenance and Psychosocial Development: A Narrative Perspective." ScholarWorks, 2013. https://scholarworks.waldenu.edu/dissertations/1091.

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Bariatric surgery is not the panacea it was once thought to be for weight loss. Due to patient noncompliance issues, many weight loss surgery patients are relapsing and regaining the significant amounts of weight that bariatric surgery had initially helped them to lose. This failure is costly monetarily, psychologically, and medically to both the patient and to society. Using the narratives of 32 post-weight loss surgery patients, this narrative study explored: (a) whether Erikson's psychosocial stages of development occur after weight loss surgery, (b) whether successful patients (defined as

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14

Josephson, Anna. "Myelin is not required for maintenance of the axon initial segment." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3090.

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Axonal pathology is a major contributor to impaired motor, sensory and cognitive dysfunction associated with multiple sclerosis particularly with the progressive forms of the disease. However, the early pathologic events responsible for axonal deterioration remain unclear. It is well recognized that maintaining proper axonal function is intimately related to proper establishment and maintenance of axonal domains such as the node of Ranvier and the axon initial segment (AIS). Numerous laboratories, including ours, have investigated the mechanisms that regulate node of Ranvier formation and main

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15

Alzubaidi, H. J. "Maintenance modelling of a major hospital complex." Thesis, University of Salford, 1993. http://usir.salford.ac.uk/2054/.

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By its nature, building maintenance requires an ability to respond to a demand that is random in time, random in nature and random in location. This in turn creates complex operational and logistical problems for management, specially if the property complex is large. The objective of this research is to assess the scope for and effectiveness of quantitative modelling, and the prediction of the outcome of alternative management action (policy), to assist in the management of building maintenance complexes of the size of a hospital. Both building and engineering equipments are encompassed withi

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16

Vasilakos, Konstantinon. "Utilization of magnified visual feedback in the maintenance of finger position." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23947.

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This study investigates the interaction between increased gain in the visual feedback loop and motor control of the periphery. Subjects were asked to maintain a constant finger position while utilizing magnified visual feedback. The accuracy of each trial was quantified by taking the standard deviation (trial-error) of the finger position. Trials performed under magnification have lower trial-errors than trials without magnification. The change in trial-error between trials with and without magnification proves greater than the difference between trials at any two magnifications. In contrast,

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17

Sauer, Juergen. "Human skill maintenance in complex work environments : applications to extended spaceflight." Thesis, University of Hull, 1997. http://hydra.hull.ac.uk/resources/hull:8298.

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This thesis examines human performance under sub-optimal working conditions during work with complex and highly-automated process control systems. The operational context focuses on applications in extended spaceflight but the generic approach allows for generalisations beyond this target work environment The methodological approach is based on the use of a computerised multiple-task environment to carry out generic simulations of real work environments (micro-worlds) with a high level of ecological validity. For that purpose, a PC-based task. environment was developed to simulate the operatio

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18

Podda, G. "PREDICTION OF OPTIMAL WARFARIN MAINTENANCE DOSE USING ADVANCED ARTIFICIAL NEURAL NETWORKS." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219087.

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Introduction. The individual response to vitamin K antagonists (VKA) is highly variable, being influenced by clinical factors and genetic variants of enzymes that are involved in the metabolism of VKA (CYP2C)) and vitamin K (VKORC1). Currently, the dose of VKA is adjusted based on measurements of the prothrombin time. In the last years, mathematical algorithms were developed for estimating the appropriate VKA dose, based on different mathematical approaches working on clinical and genetic data. Artificial Neural Networks (ANN) are computerized algorithms resembling interactive processes of th

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19

Copeland, Lauren. "Understanding the therapeutic process : mechanisms of motivational interviewing in weight loss maintenance." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/73303/.

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Background Nearly a quarter of UK adults are obese representing a significant public health problem. Motivational interviewing (MI) may be effective in helping people to lose weight. Planning could be a mechanism of action which is related to outcome. The aim is to define the types of planning talk used by clients during an MI session and examine their relation to weight loss maintenance (WLM) outcomes. Also to examine the skills the therapist used prior to a client talking about planning. Methods To define planning talk a literature review was conducted and an expert group listened to recorde

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20

Rabender, Christopher. "The Role of Nitric Oxide Dysregulation in Tumor Maintenance." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3206.

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The inflammatory nature of the tumor microenvironment provides a cytokine and chemokine rich proliferative environment. Much of the responsibility of this environment is due to the production of Reactive Oxygen Species (ROS). These studies examined the proliferative rich tumor environment from a new perspective of Nitric Oxide Synthase (NOS) dysregulation. NOS’s have the ability to become uncoupled and generate superoxide in lieu of nitric oxide (NO). A requirement of NOS for the production of NO is the cofactor tetrahydrobiopterin (BH4) and when it is missing NOS becomes uncoupled and turns i

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21

Liu, Lili 1964. "Electrophysiologic factors determining autonomic effects on the maintenance of atrial fibrillation." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27370.

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While parasympathetic activation is well-known to promote AF, the effects of sympathetic stimulation on AF have not been systematically studied. The present study was designed to study effects of sympathetic stimulation on AF, and the relative effects of sympathetic and vagal stimulation on AF duration for a comparable degree of wavelength and refractory period abbreviation. The results showed that, for a comparable degree of wavelength abbreviation, sympathetic stimulation is much less effective in promoting AF than vagal stimulation. Vagal stimulation markedly increased the heterogeneity of

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22

McKee, Heather C. "The self-regulatory factors related to weight loss and weight maintenance success and failure." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4424/.

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With the prevalence of obesity reaching epidemic levels both within the UK and worldwide there is an urgent need to explore ways in which to stem its burden on our society. There is a large body of research examining the positive effects of dietary and physical activity interventions for weight loss success, however much less is known regarding the psychological aspects, in particular the self-regulatory factors that contribute to both weight loss and weight maintenance success and failure. The current thesis examines these factors through four studies. Study one highlighted the factors relate

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23

Morrell, Allison, Halie Dyer, Courtney Smith, et al. "Evaluating the Feasibility of a Stepped-Care Protocol for Postpartum Depression via Adoption and Maintenance (Cost)." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/6621.

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Introduction: Research has shown that Postpartum Depression (PPD) occurs in 10-20% of new mothers. Symptoms of PPD include excessive sadness, increased anxiety, guilt, and possible suicidal ideation. PPD can increase a mother’s risk for health and psychological dysfunction including future psychiatric illnesses, substance abuse, and decrease her adaptive functioning. PDD can also have negative implications on child safety practices and a child’s psychosocial and developmental wellbeing. Treatments for PPD, such as medication and psychotherapy, have been shown to be effective at reducing the nu

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24

Gkouvatsos, Konstantinos. "Insights on the role of the protein hemojuvelin in the maintenance of systemic iron homeostasis." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117145.

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Iron is an essential nutrient, involved in a wide range of biochemical activities. However, its flexible coordination chemistry and favorable redox potential may render this element potentially toxic. Thus, tight and accurate regulation of iron absorption in humans is critical to prevent systemic excess or deficiency. This complex task is accomplished by hepcidin, a liver-derived peptide hormone that binds to the iron transporter ferroportin and promotes its degradation. This results in a decrease of the iron efflux from duodenal enterocytes, macrophages and hepatocytes into the blood stream.

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25

Dias, De Campos Joana. "The pleomorphic role of stromal cells in the formation and maintenance of tertiary lymphoid organs." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6994/.

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A large body of evidence supports the role of activated stromal cells in the persistence of inflammation. The switch from resting to pathogenic stroma appears to be associated with the development of tertiary lymphoid organs (TLOs) within sites of chronic inflammation. However little is known about the immunological function of the stromal component. We utilised a murine model of inducible TLO formation in inflamed salivary glands to investigate the role of activated stromal cells characterised by the expression of gp38 and FAP during TLO development. We demonstrated that during inflammation,

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26

Fasbinder, Laurie Guyton 1957. "Validation of an instrument measuring maintenance of hope in heart transplant patients." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277948.

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The purpose of this study was to revise and expand the Hope Maintenance Scale. An exploratory design was used to content analyze qualitative data collected from 226 heart transplant patients in the primary study, "Predictors of Quality of Life in Heart Transplantation". Results supported five of the six original dimensions of hope contained in the Hope Maintenance Scale. The five dimensions substantiated were: Downward Comparison, Fostering Optimism, Belief in a Powerful Other, Avoiding Painful Situations or Material, and Viewing the Situation as Temporary. Subcategories for the dimension of O

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27

Garver, Matthew J. "Improving Maintenance of Physical ACtivity Trial - Pilot (IMPACT-P)." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312202558.

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28

Lowe, Kate. "The roles of podoplanin and clec-2 in the development and maintenance of the cerebral vasculature." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5791/.

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The C-type lectin-like receptor, CLEC-2, is constitutively expressed on platelets, with reported expression on a number of leukocyte subsets in adult mice. Constitutive or platelet-specific deletion of CLEC-2 in mice induces cerebral haemorrhaging by midgestation. In this thesis, I investigated the basis of this defect, hypothesising that it is mediated by the loss of CLEC-2 activation by its endogenous ligand, podoplanin, expressed on the developing neural tube. Podoplaninfl/fl mice were crossed to mice expressing PGK-Cre to induce deletion of podoplanin at the two-cell stage. Developing bloo

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29

Goff, Carl F. "Transition from Health Maintenance Organizations to Consumer Driven Health Plans: Measurement of Initial Impacts for Members with Chronic Conditions." VCU Scholars Compass, 2007. https://scholarscompass.vcu.edu/etd/5723.

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New consumer driven health insurance products are designed to contain health care costs by making consumers more accountable for the care they receive through being responsible for more cost sharing, making decisions regarding health care providers they will use, and increasing exposure to and use of health information for services and providers. Potential benefits of consumer driven products include increased information regarding personal health and a more knowledgeable patient base. Potential drawbacks of consumer driven products include negative impacts on consumers with chronic and comple

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30

Vaught, Joy Ann. "EXPLORING NEW APPROACHES FOR WEIGHT LOSS MAINTENANCE: INTUITIVE EATING AND EMOTIONAL BRAIN TRAINING." UKnowledge, 2014. http://uknowledge.uky.edu/foodsci_etds/26.

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While traditional behavioral weight loss programs have been successful at producing weight loss, weight maintenance is difficult to achieve. Addressing stress, one major contributing factor in weight gain, may be a potential solution. The purpose of this study was to test a stress-management program (EBT) for changes in weight and blood pressure, and maintenance of those changes. Obese adults (N=33) were randomized to two weight loss groups for a seven-week intervention and a seven-week follow-up period: an intuitive eating group or a stress management group. The intuitive eating group did not

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31

Clamp, Louise Diana. "The role of metabolic rate and substrate utilization in the maintenance of body weight, body composition and insulin sensitivity." Doctoral thesis, Faculty of Health Sciences, 2019. https://hdl.handle.net/11427/32076.

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Obesity treatment requires approaches that target the reduction of body weight and fat mass. The improvement of cardiorespiratory fitness (CRF), metabolic flexibility and insulin sensitivity also contribute towards reducing obesity-associated risk factors. While energy restriction alone results in significant weight loss, exercise-only interventions provide small amounts of weight loss and prevent weight gain, while also improving many of the other variables targeted in obesity treatment. Once achieved however, successful weight-loss maintenance is challenging, with many individuals subsequent

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32

Hughes, Adrienne Rachel. "Effect of an exercise consultation on maintenance of physical activity after completion of phase III exercise-based cardiac rehabilitation." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/2526/.

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Aims: The primary aim of this randomised-controlled trial was to evaluate the effect of an exercise consultation (experimental condition) compared with standard exercise information (control condition) on maintenance of physical activity six and 12 months following completion of a phase III hospital-based exercise programme. Secondary aims included assessing the effect of an exercise consultation compared with exercise information on physiological and psychological variables at six and 12 months. Conclusions: This study demonstrated that the exercise consultation was more effective than exerci

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33

Lewis, Cheri Renee. "Healthy Weight Maintenance: Narrative Analysis of Weight Cycling in the Formerly Obese." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2003.

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Medical and economic costs for obesity are estimated at $147 billion per year, yet less than 1/3 of overweight individuals successfully maintain weight loss. The literature is replete with descriptions of the problem and research on treatments, yet demonstrations of effective loss and maintenance are lacking. Missing is an understanding of the experiences of individuals who successfully maintained healthy weight loss, which could provide insights regarding effective psycho-social interventions. The purpose of this qualitative narrative study was to explore key events and experiences in the liv

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De, Villiers Marietjie Rene. "The development of content and methods for the maintenance of competence of generalist medical practitioners who render district hospital services." Thesis, Stellenbosch : University of Stellenbosch, 2004. http://hdl.handle.net/10019.1/16044.

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Thesis (PhD)--University of Stellenbosch, 2004.<br>ENGLISH ABSTRACT: District hospitals play a pivotal role in the district health system of the Western Cape and other provinces of South Africa. It is a dual role, supporting both primary health care services and serving as a gateway to higher levels of care. Most district hospitals are in rural areas, staffed by generalist medical practitioners who provide health services often supplied by specialists in urban areas. There is a paucity of research and published material on the scope of practice of district hospital practitioners in South

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35

Cabatingan, Mark S. "Mechanisms of Establishment and Maintenance of RNA Virus Persistence in Primary Lymphocytes: a Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/125.

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RNA virus persistence in lymphocytes has been studied extensively in vitro, but the influence of lymphocyte homeostatic mechanisms and antiviral immunity on persistence has not been well studied in an in vivo system. It is demonstrated here that vesicular stomatitis virus (VSV), a negative-strand RNA virus, is maintained in B lymphocytes in vivo despite the existence of homeostatic mechanisms that drive the cells to proliferate under conditions of B cell deficiency and a strong antibody response to the virus. It is also shown that antiviral antibodies inhibit VSV reactivation from persistently

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36

Saunders, Christine V. "Role of glucose, acetate and plasma in the maintenance of mitochondrial function, energy metabolism and cell integrity during platelet storage in additive solutions." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/47076/.

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A potential benefit of the use of artificial media for the suspension of platelets as concentrates is a reduction of the morphological, functional and metabolic changes observed in platelets during storage and collectively referred to as the platelet storage lesion (PSL). A better understanding of the nature of the PSL may suggest strategies for manipulation of the storage environment to improve platelet viability and efficacy posttransfusion. In this context, two principal considerations formed the basis for the study: · The hypothesis that apoptosis is a central mechanism responsible for the

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Hollinger, Laura Suvajee Good. "Maintenance of hope among Thai HIV/AIDS patients in a Buddhist temple-based care center /." Abstract, 2000. http://mulinet3.li.mahidol.ac.th/thesis/2543/43E-Laura-H.pdf.

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38

Drury-Stewart, Danielle Nicole. "Controlling the microenvironment of human embryonic stem cells: maintenance, neuronal differentiation, and function after transplantation." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45967.

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Precise control of stem cell fate is a fundamental issue in the use of human embryonic stem (hES) cells in the context of cell therapy We examined three ways in which the microenvironment can be controlled to alter hES cell behavior, providing insight into the best conditions for maintenance of pluripotency and neural differentiation in developmental and therapeutic studies. We first examined the effects of polydimethylsiloxane (PDMS) growth surfaces on hES cell survival and maintenance of pluripotency. Lightly cured, untreated PDMS was shown to be a poor growth surface for hES cells. Some of

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Raisch, Dennis William. "Impact of case scenarios in an educational program to change drug prescribing in a health maintenance organization." Diss., The University of Arizona, 1988. http://hdl.handle.net/10150/184600.

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This dissertation evaluated the provision of two different one-to-one educational interventions, randomly assigned, to two separate groups of medical practitioners at a health maintenance organization (HMO), Cigna Healthplan of Tucson, Arizona. A control group received no intervention. Each group consisted of seven physicians and one nurse practitioner. The intervention was aimed at improving the prescribing of the anti-ulcer drugs, cimetidine, ranitidine, and sucralfate. The theoretical basis for the study involved the cognitive principle of vividness, which implies that more vivid informatio

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Iwakoshi, Neal N. "Induction and Maintenance of Transplantation Tolerance by Treatment with a Donor Specific Transfusion and Anti-CD154 mAb: a Dissertation." eScholarship@UMMS, 2000. http://escholarship.umassmed.edu/gsbs_diss/219.

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A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study the mechanisms involved in the induction of allograft survival, we determined the fate of tracer populations of alloreactive T cell receptor (TcR) transgenic CD8+ T cells circulating in a normal microenvironment. In the first portion of this thesis, we observed that DST plus anti-CD154 mAb prolonged allograft survival and deleted alloreactive TcR transgenic CD8+ T cells. Neither component alone did

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Black, Kathleen Scarlett. "EFFECTS OF FESCUE HERBICIDES PLATEAU® AND CIMARRON® ON PREGNANCY MAINTENANCE IN BROODMARES AND ON ALKALOID CONCENTRATIONS IN ENDOPHYTE INFECTED TALL FESCUE." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_theses/540.

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Ingestion of endophyte infected (E+) fescue by pregnant mares can cause significant reproductive problems. Plateau® and Cimarron® herbicides suppress fescue while leaving desired forages unharmed. To determine if these herbicides are harmful to pregnant mares, they were allowed to graze pastures treated with Plateau®, Cimarron®, or vehicle carrier. Pregnancies were monitored via ultrasonography, blood chemistry, and hematology. Of the components measured only creatinine differed among treatments over time (P=0.0003) and that increase was only significant in one of four studies. Two additional

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Pageau, Gayle Jeannette. "Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/331.

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The development of cancer is a multi-step process which involves a series of events, including activation of oncogenes and loss of tumor suppressor function, leading to cell immortalization and misregulated proliferation. In the last few years, the importance of epigenetic defects in cancer development has become increasingly recognized. While most epigenetic studies focus on silencing of tumor suppressors, this thesis addresses defects in the maintenance of silenced heterochromatin in cancer, particularly breast cancer. Breast cancer is a leading cause of cancer in women and many familial

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Pageau, Gayle Jeannette. "Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/331.

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The development of cancer is a multi-step process which involves a series of events, including activation of oncogenes and loss of tumor suppressor function, leading to cell immortalization and misregulated proliferation. In the last few years, the importance of epigenetic defects in cancer development has become increasingly recognized. While most epigenetic studies focus on silencing of tumor suppressors, this thesis addresses defects in the maintenance of silenced heterochromatin in cancer, particularly breast cancer. Breast cancer is a leading cause of cancer in women and many familial

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Campbell, William W. III. "A COMPARISON OF QUALITY INDICATORS BETWEEN MEDICARE ACCOUNTABLE CARE ORGANIZATIONS AND HEALTH MAINTENANCE ORGANIZATIONS USING PUBLICLY AVAILABLE DATA." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5284.

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The purpose of this study is to explore differences in quality between Medicare Accountable Care Organizations (ACO) and Health Maintenance Organizations (HMO). Three outcomes measures reported by these plans use different methodologies but possess enough alignment to permit comparison: percent of diabetic patients with last HbA1c > 9.0%, colon cancer screening rate and ER visits per 1,000. These outcomes are the dependent variables (DV). A secondary purpose is to explore differences in quality based on the size of the beneficiary population served, using the same measures. As the Medicare

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Solberg, Jerry. "Low back pain algorithm : its effect on the incidence of spinal surgeries within senior HMO." Scholarly Commons, 1998. https://scholarlycommons.pacific.edu/uop_etds/2343.

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In today's health care environment tremendous efforts are being made by Health Maintenance Organizations (HMOs) to deliver appropriate patient care while controlling utilization of services and costs. One area of concern over the past two years has been the apparent over-utilization of spinal surgeries within a local Senior HMO. This HMO has no specific plan or physician guidelines for the management of low back pain. Utilization of spinal surgeries is measured in incidence of admissions per thousand members of the Senior HMO. Over the past two years the incidence of spinal surgeries per thous

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46

Herman, Heather. "The Role of Sulfatide in the Development and Maintenance of the Nodal and Paranodal Domains in the Peripheral Nervous System." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/328.

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Sulfatide is a galactolipid and a major lipid component of the myelin sheath. Its production is catalyzed by the enzyme cerebroside sulfotransferase (CST). To determine the functions of sulfatide, the gene encoding CST was genetically disrupted resulting in mice incapable of sulfatide synthesis. Using these mice, it has been shown in the central nervous system (CNS) that sulfatide is essential for normal myelin synthesis and stability even though the onset of myelination is not impaired. Additionally, proper initial clustering of paranodal proteins and cluster maintenance of nodal proteins is

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47

Gustavsson, Annica. "Obesa personers upplevelser och hantering av viktnedgång : En litteraturstudie." Thesis, Högskolan i Borås, Institutionen för Vårdvetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-18871.

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Övervikt och fetma beror till stor del på ändrade levnadsvanor och är ett problem att ta på största allvar eftersom fetma kan leda till allvarliga följdsjukdomar och sänkt livskvalitet. Preventiva åtgärder är nödvändiga för att hindra den fortsatta fetmaepidemin och här kan sjuksköterskan fylla en viktig funktion som stödjare och rådgivare för obesa personer. Syftet är att beskriva vuxna obesa personers upplevelser och hantering av viktnedgång. Metoden som använts är litteraturbaserade studier av åtta kvalitativa artiklar.De obesa personernas upplevelser framkommer i tre teman. Upplevelser inn

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48

Ferreyra, Ramirez Ernesto Fernando. "Metodologia de priorização de equipamentos medicos para programas de manutenção preventiva em hospitais." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/259864.

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Orientador: Said Jorge Calil<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação<br>Made available in DSpace on 2018-07-21T20:43:49Z (GMT). No. of bitstreams: 1 FerreyraRamirez_ErnestoFernando_M.pdf: 4191425 bytes, checksum: f333b450c6c2fa05078c8f9cc47d9f7c (MD5) Previous issue date: 1996<br>Resumo: Atualmente, as pressões para aumento da segurança e disponibilidade dos equipamentos médicos, e a limitação de recursos humanos e financeiros têm mostrado a necessidade de implantação de programas de manutenção preventiva. O alto custo d

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49

Martin, Rebecca. "The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/588.

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ADAM10 is a zinc-dependent metalloprotease. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In this study, we examined the role of ADAM10 in the immune system. Here, we show that knocking out ADAM10 on the mature B2 cell causes a defect in the development of secondary lymphoid architecture that becomes more severe post-immunization. We also show that overexpression of ADAM10 leads to a defect in hematopoiesis, which eliminates B2 lymphocyte development. This defect additionally indu

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Abreu, Alexandra Sofia Isabel de. "Gestão de infra-estruturas e avaliação de equipamentos laboratoriais." Master's thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/9668.

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RESUMO: A confiabilidade e qualidade dos resultados clínicos de um laboratório, estão dependentes da qualidade do equipamento onde estes são processados. A qualidade de um equipamento consiste em apresentar resultados com uma confiabilidade metrológica de acordo com os processos de medição realizados. Desta forma, os equipamentos de medição devem conter características metrológicas de acordo com os requisitos dos processos que estão inseridos, tais como: erro máximo, incerteza, resolução… Todos os equipamentos por muito bons que sejam, apresentam perdas das suas características metrológicas

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