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Dissertations / Theses on the topic 'Medicinal plant produce'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mbandezelo, Mongikazi. "Bioactive compounds in a Manayi traditional medicinal product from East London." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2450.

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Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2016.<br>In Africa, herbal medicines are often used as primary treatments for a variety of ailments and diseases including HIV/AIDS and for HIV-related problems. In general, traditional medicines are not well researched scientifically in controlled studies, and are poorly regulated. Since the pharmacological effectiveness of natural products is affected by several native and foreign factors, studies on the variations of chemical composition and biological activity of these medicines are necessary. The processes of investigat

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2

MELO, Joabe Gomes de. "Controle de qualidade e prioridades de conservação de plantas medicinais comercializadas no Brasi." Universidade Federal Rural de Pernambuco, 2007. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4834.

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Submitted by (edna.saturno@ufrpe.br) on 2016-06-21T11:47:19Z No. of bitstreams: 1 Joabe Gomes de Melo.pdf: 684319 bytes, checksum: cc3b5dfd30a58d6614ad0cd1a29bc5cc (MD5)<br>Made available in DSpace on 2016-06-21T11:47:19Z (GMT). No. of bitstreams: 1 Joabe Gomes de Melo.pdf: 684319 bytes, checksum: cc3b5dfd30a58d6614ad0cd1a29bc5cc (MD5) Previous issue date: 2007-02-14<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Almost all the world’s populations use medicinal plants, or their derivates, for the treatment of illnesses. In Brazil, these plants hav

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3

Chau, Yasmin-Pei(Yasmin-Pei Kamal). "Biosynthesis and medicinal chemistry of therapeutically promising plant natural products." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122839.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Modern molecular biology, biochemical, and chemical techniques have made it possible to identify individual natural products that possess pharmacological activity from medicinal plants. While approximately 50% of all new FDA-approved small molecule therapeutics in the past 40 years were natural products or natural product analogs, challenges including limited natural resources and the difficulty of solving the tota

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4

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Thesis, Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315/.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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5

Wangchuk, Phurpa. "Bioactive alkaloids from medicinal plants of Bhutan." Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/315.

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Natural products had been indispensably used by many cultures and traditions in folklore medicines for thousands of years. These traditional medicines cater to about 85% of the world population for their primary health care needs. Natural products have been intensively explored also for their bioactive pharmacophores by modern pharmaceutical companies. In fact they are the skeletal framework of about 60% of the modern drugs that are available today. Of these, about 80% of antibacterial drugs and 90% of antimalarial drugs are natural derivatives. One of the interesting secondary metabolite grou

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6

Essack, Magbubah. "Screening extracts of indigenous South African plants for the presence of anti-cancer compounds." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8767_1210844967.

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<p>Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. Scientists have thus established a branch of research called natural product research. This branch of research involves the identification and purification of secondary metabolites with a specific biological activity. The methodology involves the screening of plant products for a specific biological activity, purification of the biologically active natural product by separa

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7

COLLU, MARTA. "Endocannabinoid System Modulation By Natural Products From Ancient Medicinal Plants." Doctoral thesis, Università degli Studi di Cagliari, 2019. http://hdl.handle.net/11584/260056.

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Herbal drugs have been important for the treatment of multiple pathological conditions since ancient times. A multitude of historical texts document the importance of plant-based therapies, but the therapeutic effectiveness of many described applications remains questionable. Concomitantly, the pharmacological properties and the associated chemistry of many herbal drugs described in ancient texts remain poorly studied. The development of modern pharmacology and analytical tools in the past century has led to the discovery of a plethora of novel plant-derived compounds and propelled advancement

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8

Faraone, Immacolata. "Pharmacological potential and phytochemical profile of three unexplored medicinal plants." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4256.

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2017 - 2018<br>Nature is a wide source of biologically active compounds investigated with the purpose to be used as drugs due to their biological activity and also useful in pharmaceutical discovery and drug design. Nowadays, medicinal plants play a major role in primary health care as therapeutic remedies in many developing countries. The aim of my PhD project was the phytochemical and biological investigation of three plant species, used in Bolivian traditional medicine, but few scientific studies were reported, such as: Azorella glabra Wedd., Minthostachys diffusa Epl. and Senecio cli

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9

Harris, Taahir. "Bambara groundnut (Vigna subterranean) from Mpumalanga province of South Africa: phytochemical and antimicrobial properties of seeds and product extracts." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2789.

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Thesis MTech (Food Technology))--Cape Peninsula University of Technology, 2017.<br>Bambara groundnut (Vigna subterranea) an indigenous legume cultivated in Sub-Saharan Africa has been proclaimed to have medicinal properties from communities and in rural areas. However, there is not enough scientific information to validate these claims. Therefore, this study aimed to identify possible medicinal properties of Bambara groundnut (BGN), by analysing the phytochemical and antimicrobial properties of BGN seed and product extracts from Mpumalanga province within South Africa. The BGN extracts (70% me

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10

Sibandze, G. F. "Antimicrobial and efflux inhibiting activity of natural products from Swazi medicinal plants." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041384/.

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Plant-derived medicines have played a major role in the history of man, especially as anti-infective agents. In the wake of the emergence of multidrug-resistant microbial infections, natural products are still a potential source of drug leads since they contain a wide array of structurally diverse compounds. Alongside the classical approach of finding anti-infective agents, this study also sought to investigate the potential of Swazi medicinal plants as efflux inhibitors in bacterial cell systems. This is because bacteria utilise the efflux system to avert the inhibitory action of antibiotics

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11

Altemimi, Ammar Badran. "ULTRASONIC APPLICATIONS- PHYTOCHEMICAL ANALYSES OF SOME MEDICINAL NATURAL PRODUCTS IN FOOD PLANTS." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1149.

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There are concerns about using synthetic phenolic antioxidants such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) as food additives because negative effects to human health have been reported. thus, a replacement of these synthetics by antioxidant extractions from various foods has been proposed. By the generation of more than eight thousand different phenolics, fruits and vegetables are the prime sources of natural antioxidants. The consumption of fruits and vegetables has been strongly linked with several health benefits, a result of their medicinal properties and high

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12

Albrecht, Matthew A. "Reproductive Biology of Medicinal Woodland Herbs Indigenous to the Appalachians." Ohio : Ohio University, 2006. http://www.ohiolink.edu/etd/view.cgi?ohiou1163427974.

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13

Mbaebie, Oyedemi B. O. "Antiplasmid and antimicrobial activities of synthetic and natural products from selected medicinal plants." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1468641/.

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This PhD thesis is part of ongoing project to identify plant natural products and selected synthetic compounds that possess antimicrobial properties; and are able to promote plasmid loss or interfere with bacterial conjugation. The conjugative broad host plasmids investigated include PKM101 (Inc N), TP114 (Inc I2), PUB307 (Inc P), and low- copy number plasmids: R6K (Inc X), R7K (Inc W) and R1-drd-19 (Inc F11). They represented the incompatibility plasmid groups that are currently associated with gross dissemination of antibiotic resistance in bacteria. A series of plant extracts evaluated at s

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14

Maoela, Manki Sarah. "Studies on some biologically active natural products from Tulbaghia Alliacea." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&amp.

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It is believed that early humans had knowledge of how to use traditional medicinal plants, but the knowledge has been partially lost as society underwent various changes leading to new civilizations. The aim of this study was to isolate and identify natural product constituents from Tulbaghia Alliacea. There has not yet been any scientifically conducted investigation on the plant. Tulbaghia Alliacea is used for fever and colds, asthma, pulmonary tuberculosis and stomach problems.

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15

Fang, Yuan Yuan. "In vitro drug-herb interaction potential of African medicinal plant products used by Type II diabetics." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1341.

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In Africa, use of medicinal plants for the treatment of diabetes is very common. However, efficacy on co-administering of medicinal plants with therapeutic drugs hasn't been fully determined, especially for African medicinal plants. The current study focused on assessing the in vitro modulation effects of three popular African medicinal plants, namely: Aloe ferox, Sutherlandia frutescens and Prunus africana (including five commercial preparations containing these medicinal plants) on two of the most important anti-diabetic drug metabolising enzymes, Cytochrome P450 (CYP450) 2C9 and CYP3A4 and

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16

Belewa, Xoliswa Vuyokazi. "The effect of tulbaghia violacea plant extract on the growth of aspergillus species." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1008186.

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Traditional medicine has become an important part of healthcare worldwide. It is estimated that about 25 percent of prescribed medicines contain plant products or active compounds derived from plants. In South Africa, traditional medicine forms part of the culture and tradition of most communities. Garlic compounds have been shown to have a variety of antimicrobial properties. Amongst these are antifungal, antibacterial, antiviral and anti protozoal activities. Allicin and its breakdown products have been shown to be the main active compounds which possess these properties. Tulbaghia violacea

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17

Yatsuda, Regiane. "Avaliação da atividade anti-carie dos compostos bioativos isolados das plantas Mikania laevigata Schultz Bip. ex Baker e Mikania glomerata Sprengel." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288520.

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Orientadores: Pedro Luiz Rosalen, Hyun Koo<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-07T01:21:21Z (GMT). No. of bitstreams: 1 Yatsuda_Regiane_D.pdf: 2220152 bytes, checksum: af7c550978d5b4b9b4ba19a84d7cb6c0 (MD5) Previous issue date: 2006<br>Resumo: O uso de plantas medicinais vem crescendo nos últimos anos e isto é devido principalmente as descobertas de suas propriedades biológicas, e entre estas plantas destacam-se as do gênero Mikania. Assim, a procura pela descoberta de novos produtos naturais c

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18

Ko, Yuen-yi, and 高婉儀. "Synthetic studies of (-)-curcumol and its related natural products." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245420.

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19

Littleton, Robert M. "Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355501728.

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20

Bailey, Brent. "Social and economic impacts of wild harvested products." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=968.

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Thesis (Ph. D.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains viii, 103 p. : ill. (some col.), maps. Vita. Includes abstract. Includes bibliographical references (p. 81-83).

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21

Morujo, Nuno Filipe Claro. "Caracterização dos produtores de plantas aromáticas e medicinais em modo de produção biológico em Portugal." Master's thesis, ISA, 2010. http://hdl.handle.net/10400.5/6574.

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Mestrado em Engenharia Agronómica - Economia Agrária e Gestão do Território - Instituto Superior de Agronomia<br>This paper concerns a study on the production of aromatic and medicinal plants (MAP) in Portugal. These species have always been considered as interesting in cultural, social, culinary and medicinal but only recently acquired an economic interest. Global growth of organic farming and market demand in this direction led to the production of specific interest in MAP organic production (MPB). In the particular case of Portugal, are known two ways to get these plants: cultivation a

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22

Bastos, Gisele Medeiros. "Uso de preparaÃÃes caseiras de plantas medicinais utilizadas no tratamento de doenÃas infecciosas." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=730.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>A maioria da populaÃÃo de paÃses em desenvolvimento utiliza plantas ou prepara-ÃÃes vegetais em seus cuidados bÃsicos de saÃde. A falta de informaÃÃes sobre os possÃveis riscos e benefÃcios do uso de plantas medicinais Ã um dos principais fato-res que contribui para automedicaÃÃo da populaÃÃo com ervas. Muitas das espÃcies vegetais utilizadas na medicina popular apresentam propriedades antimicrobianas comprovadas, no entanto, diversos fatores como a preparaÃÃo incorreta das plantas pode interferir na eficÃcia do tratamen

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23

Squires, Jill Marie. "The Effects of Naturally Occurring Plant Products on Experimental Haemonchus contortus Infection in Gerbils and Sheep." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/32598.

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Haemonchus contortus is a blood-sucking abomasal helminth of small ruminants responsible for major economic losses to producers worldwide. Widespread resistance to commercial anthelmintics has created a need for alternative methods of parasite control. One method involves using plant products with natural anthelmintic properties. This thesis assessed the efficacy of several plant products against experimental Haemonchus contortus infection in gerbils and sheep. <p> In gerbil assays, animals were orally infected with 600 third-stage Haemonchus larvae and treated once or daily for 5 days wit

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24

Naman, Charles Benjamin. "Phytochemical Investigation of the Medicinal Plant Taxodium distichum and Library Screening of Thalictrum Alkaloids for New Antileishmanial Drug Leads." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429283826.

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25

Osorio, Adriana de Carvalho. "Controle de qualidade do extrato fluido e tintura de guaco (Mikania glomerata Sprengel)." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-13012015-101303/.

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O guaco (Mikania glomerata Sprengel) é uma planta medicinal brasileira empregada em medicamentos para tosse e problemas respiratórios. Devido ao interesse que esta espécie desperta e a popularidade de sua utilização estão sendo realizados estudos fitoquímicos e farmacológicos. O objetivo deste trabalho foi desenvolver metodologia para o controle de qualidade do extrato fluido e tintura desta planta, a partir da escolha de uma substância marcadora - a cumarina (1,2-benzopirano), e pesquisar um método de doseamento preciso, exato e de fácil execução. Primeiramente, testou-se o método da A.O.A.C.

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Chamberlain, James Luther. "The Management of National Forests of Eastern United States for Non-Timber Forest Products." Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/30053.

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Many products are harvested from the forests of the United States in addition to timber. These non-timber forest products (NTFPs) are plants, parts of plants, or fungi that are harvested from within and on the edges of natural, disturbed or managed forests. Often, NTFPs are harvested from public forests for the socio-economic benefit they provide to rural collectors. Social science and market research methods were used to examine the extent that NTFPs are addressed in national forest management plans, identify and explore issues that affect their management, and determine the attitudes and

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27

Souza, Eloísa Portugal Barros Silva Soares de. "Estudo da atividade moluscicida das plantas oriundas da Restinga de Jurubatiba." Niterói, 2017. https://app.uff.br/riuff/handle/1/3045.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-03-13T19:47:55Z No. of bitstreams: 1 Souza, Eloísa Portugal Barros Silva Soares de [Dissertação, 2016].pdf: 2352165 bytes, checksum: 60f359e59fc6b6d7aae22ce45641b075 (MD5)<br>Made available in DSpace on 2017-03-13T19:47:55Z (GMT). No. of bitstreams: 1 Souza, Eloísa Portugal Barros Silva Soares de [Dissertação, 2016].pdf: 2352165 bytes, checksum: 60f359e59fc6b6d7aae22ce45641b075 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>O estudo das plantas medicinais tem-se tornado uma importante fonte

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28

Arruda, Frommenwiler Débora. "Comprehensive high performance thin layer chromatography (HPTLC) fingerprinting in quality control of herbal drugs, preparations and products." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671745.

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Quality control of herbals has its roots in the study of morphoanatomic and organoleptic characters. Nevertheless, in the last century, with the evolution of analytical chemistry, the quality control rapidly evolved from elementary tests to the use of sophisticated instruments combined with software for data management. In the current days, many authorities and organizations recommend a suite of tests, featuring many of these instruments, to evaluate quality of herbal products. HPTLC offers a comprehensive set of data that can be used not only for identification but also to evaluate the purity

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29

POKORNY, CLAIRE. "Les residus phytosanitaires dans les drogues vegetales." Strasbourg 1, 1992. http://www.theses.fr/1992STR15049.

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Amaral, Fabiano Pereira do [UNESP]. "Compostos fenólicos de Paepalanthus geniculatus (Eriocaulaceae)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/105826.

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Made available in DSpace on 2014-06-11T19:35:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-06-18Bitstream added on 2014-06-13T21:07:21Z : No. of bitstreams: 1 amaral_fp_dr_araiq.pdf: 4513783 bytes, checksum: e99f12bcbcd5a5642dd150965f5e0fd8 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>No Brasil, 31 espécies vegetais de Paepalanthus foram registradas no Estado de Minas Gerais, no topo da Serra do Espinhaço, o principal centro de diversidade de Eriocaulaceae do Brasil e mais de 400 espécies de Paepalanthus e estão distribuídas geograficamente do

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Ntie-Kang, Fidele [Verfasser], Wolfgang [Gutachter] Sippl, Gerhard [Gutachter] Wolber, and Frank M. [Gutachter] Boeckler. "Drug discovery from African medicinal plants : natural product database development, lead discovery and toxicity assessment ; kumulative Habilitationsschrift / Fidele Ntie-Kang ; Gutachter: Wolfgang Sippl, Gerhard Wolber, Frank M. Boeckler." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2021. http://d-nb.info/1229436553/34.

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32

Wright, Colin W. "Recent developments in research on terrestrial plants used for the treatment of malaria." Royal Society of Chemistry, 2010. http://hdl.handle.net/10454/4541.

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no<br>New antimalarial drugs are urgently needed to combat emerging multidrug resistant strains of malaria parasites. This Highlight focuses on plant-derived natural products that are of interest as potential leads towards new antimalarial drugs including synthetic analogues of natural compounds, with the exception of artemisinin derivatives, which are not included due to limited space. Since effective antimalarial treatment is often unavailable or unaffordable to many of those who need it, there is increasing interest in the development of locally produced herbal medicines; recent progre

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Moreira, Francisco JosÃ Carvalho. "Hospedabilidade de plantas ornamentais e medicinais a Meloidogyne incognita (Kofoid & White, 1919) Chitwood (1949), raÃa 2 e controle alternativo com Ãleos essenciais." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2189.

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CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior<br>A necessidade de controlar os fitonematÃides existentes em determinada regiÃo Ã condiÃÃo bÃsica para se proceder ao seu manejo racional. Igualmente, tem-se a necessidade de proceder a estudos de produtos naturais, pois serÃ de grande valia como medida de controle alternativo, principalmente na agricultura orgÃnica. Em vista disso, este trabalho se propÃs a estudar a hospedabilidade de plantas ornamentais e medicinais a Meloidogyne incognita raÃa 2 e o controle alternativo com Ãleos essenciais. Para tanto, realizaram-se trÃs ensaios: no primei

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Santos, Cliomar Alves dos. "Mecanismos de ação antinociceptiva do extrato etanólico da entrecasca da Caesalpinia pyramidalis." Universidade Federal de Sergipe, 2015. https://ri.ufs.br/handle/riufs/3573.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Pain is one of the major health problems, leading people to search for treatment. A pharmacological screening showed that the Caesalpinia pyramidalis ethanol extract (EE) reduces nociception behavior in the writhing, formalin, and hot plate tests in mice. In order to assess the mechanism of action of EE of C. pyramidalis, substrate, antagonists or inhibitors of different pathways involved in nociception were used in the writhing model. To select the dose, mice (n = 6 per group) were pretreated with EE of C. pyramidalis (10, 30, o

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35

Melo, Ingrid Sofia Vieira de. "Determinação da atividade antiglicante de extratos de plantas sobre produtos de glicação avançada (AGE) in vitro." Universidade Federal de Alagoas, 2015. http://www.repositorio.ufal.br/handle/riufal/2062.

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Advanced glycation end products the (AGE) comprise a series of compounds, quite different, whose activity is related to their ability to modify the chemical and functional properties of diverse biological structures. Several studies, including that used animals, indicate that AGE restriction in the diet can have many protective effects. Furthermore, the use of certain medicinal plants appears to offer additional benefits, especially to individuals suffering from disorders associated with excessive accumulation of AGE. It is believed that plants combiam antiglicantes and antioxidant properties,

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Ostrosky, Elissa Arantes. "Avaliação da eficácia e segurança do extrato de folhas de Rubus rosaefolius Sm. visando a aplicação como conservante em produtos cosméticos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-28092009-105736/.

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Os produtos cosméticos e farmacêuticos contendo componentes de origem natural têm aumentado significativamente nos últimos anos. Com o objetivo de utilizar esses componentes como conservante em formulações cosméticas, determinou-se a atividade antimicrobiana do extrato bruto de folhas de Rubus rosaefolius Sm. e suas frações. Aquele de melhor desempenho foi avaliado quanto à toxicidade in vitro e seu comportamento em formulações cosméticas (creme, gel e xampu), relacionado à estabilidade, eficácia do sistema conservante e compatibilidade epidérmica. A atividade antimicrobiana foi determinada pe

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37

Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

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Suzuki, Érika Yoko. "Óleo essencial de Origanum vulgare Linnaeus: uma alternativa contra as principais bactérias causadoras de mau odor." Universidade Federal de Juiz de Fora, 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/1023.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-03-23T15:35:19Z No. of bitstreams: 1 erikayokosuzuki.pdf: 1480848 bytes, checksum: 4b319cc240f8cc66bfe8acfff3553a99 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-04-24T02:33:09Z (GMT) No. of bitstreams: 1 erikayokosuzuki.pdf: 1480848 bytes, checksum: 4b319cc240f8cc66bfe8acfff3553a99 (MD5)<br>Made available in DSpace on 2016-04-24T02:33:09Z (GMT). No. of bitstreams: 1 erikayokosuzuki.pdf: 1480848 bytes, checksum: 4b319cc240f8cc66bfe8acfff3553a99 (MD5) Previous issue date: 2013-

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Pires, Edjane Vieira. "Estudo fitoquímico da espécie Serjania lethalis St. Hil." Universidade Federal de Alagoas, 2008. http://repositorio.ufal.br/handle/riufal/1074.

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The brazilian is biodiversity considered one of higher of the world, is a bit know and explored as the source of drugs medicines. In search of new bioactive molecules the etanolic extract of stem of Serjania lethalis St. Hil was studied in for the molluscicide, miracicide and shistossomicida activity. The specie S. lethalis was collected in Brasilia and a voucher is deposited in the Herbarium of Federal University of Brasilia under the number JEP 3698 UB. After dried end reduced to powder the stem of S. lethalis was extracted in Soxhlet apparatus with ethanol 95%. The crude ethanol extr

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Baldauf, Cristina 1978. "Ecology, conservation and sustainable management of Janaguba (Himatanthus drasticus; Apocynaceae) in the Brazilian savanna = Ecologia, conservação e manejo de Janaguba (Himatanthus drasticus; Apocynaceae) no cerrado brasileiro." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/315020.

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Orientadores: Flavio Antonio Maës dos Santos, Anete Pereira de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T14:51:42Z (GMT). No. of bitstreams: 1 Baldauf_Cristina_D.pdf: 5411904 bytes, checksum: 0b452c576f0ddde99b1c88164de1b175 (MD5) Previous issue date: 2013<br>Resumo: O resumo poderá ser visualizado no texto completo da tese digital<br>Abstract: The abstract is available with the full electronic document<br>Doutorado<br>Biologia Vegetal<br>Doutora em Biologia Vegetal

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Ferreira, Edgard Antonio. "2-Acil-cicloexano-1,3-dionas de Peperomia trineura (Miq.)." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-06102009-132951/.

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O extrato bruto da planta inteira (Peperomia trineura) foi submetido à cromatografia de adsorção em sílica gel, cromatografia em camada delgada preparativa (CCDP) e CLAE semipreparativa, resultando no isolamento de cinco policetídeos inéditos em função do comprimento ou presença da insaturação na cadeia alquílica. A elucidação estrutural destes policetídeos foi realizada com base nas analises espectroscópicas de RMN 1D e 2D, infravermelho e espectrometria de massas de baixa e alta resolução. As frações provenientes do extrato bruto foram testadas frente a duas linhagens de células leucêmicas (

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Gainche, Maël. "Etudes phytochimiques et activités anti-inflammatoires de plantes médicinales auvergnates." Thesis, Université Clermont Auvergne‎ (2017-2020), 2020. http://www.theses.fr/2020CLFAC001.

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Le projet Plantinauv dans lequel s’inscrivent les travaux de ce mémoire de thèse, a pour but la valorisation du patrimoine botanique d’Auvergne en identifiant des plantes d’intérêts alimentaires et médicinales possédant des activités anti-inflammatoires, et de permettre leur commercialisation (ou celle de leurs bioactifs isolés) sous la forme de produits nutraceutiques, cosmétiques et/ou vétérinaires. Ce projet implique un consortium de partenaires académiques (UMR UNH) et industriels du pôle de compétitivité Vegepolys Valley (Greentech, Domes Pharma, AltoPhyto). Parmi les plantes de la flore

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Vasconcelos, Inácio Ricardo Alves. "Investigação dos efeitos antibacteriano, antioxidante, citotóxico e genotóxico do óleo essencial do caule de Croton tricolor Klotzsch ex Baill." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8639.

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Submitted by Márcio Maia (marciokjmaia@gmail.com) on 2016-09-08T20:43:23Z No. of bitstreams: 1 arquivototal.pdf: 1314156 bytes, checksum: 53176e3b5e1286467ff179df2731a8da (MD5)<br>Made available in DSpace on 2016-09-08T20:43:23Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 1314156 bytes, checksum: 53176e3b5e1286467ff179df2731a8da (MD5) Previous issue date: 2015-08-26<br>The use of natural products by man goes back to the origins of the human species, which over the evolutionary process, was learning how to select plants for their food and for the relief of their ailments and diseases. E

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Rozza, Ariane Leite [UNESP]. "Atividade gastroprotetora do óleo essencial de Citrus lemon (Rutaceae), de seus componentes principais Limoneno e β-pineno e do óleo essencial de Croton cajucara (Euphorbiaceae)". Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/91670.

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Made available in DSpace on 2014-06-11T19:25:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-04-30Bitstream added on 2014-06-13T20:33:01Z : No. of bitstreams: 1 rozza_al_me_botib.pdf: 637817 bytes, checksum: 8ebe24dd454c0104e96eebe3786bda97 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O presente trabalho teve como objetivos testar a atividade gastroprotetora de úlceras gástricas e mecanismos de ação do óleo essencial de Croton cajucara (CC), do óleo essencial de Citrus lemon (CL) e d

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45

Rozza, Ariane Leite. "Atividade gastroprotetora do óleo essencial de Citrus lemon (Rutaceae), de seus componentes principais Limoneno e β-pineno e do óleo essencial de Croton cajucara (Euphorbiaceae) /". Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/91670.

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Resumo: O presente trabalho teve como objetivos testar a atividade gastroprotetora de úlceras gástricas e mecanismos de ação do óleo essencial de Croton cajucara (CC), do óleo essencial de Citrus lemon (CL) e dos constituintes majoritários de CL, que são o Limoneno (L) e o β- pineno (P). Assim, foram realizados modelos de indução de úlcera gástrica por etanol absoluto para CL, L, P e CC e por droga anti-inflamatória não esteroidal (Indometacina) para CL, L e P. Todos os resultados foram expressos em média  epm (p<0.05). No modelo de indução de úlceras por etanol absoluto, a área das lesões (m

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Adawi, Rahim. "Preventing fatal effects of overworking : Product design solution." Thesis, Högskolan i Skövde, Institutionen för ingenjörsvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15473.

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“Overworking to death” is a phenomenon that has been noticeable in developing countries. The cause of death is mainly through ischemic strokes. While the victims’ occupations differed, they all shared a common characteristic, being positioned in a sedentary work, ranging from IT workers to doctors. This project’s aim was to develop a product that prevented or decreased the strokes that derived from sedentary overwork. This was mainly tackled by preventing one of the three causes of developing blood props, slowed blood flow. In order to gather rich data of the phenomenon, a qualitative study wa

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Silva, Ana Mara de Oliveira e. "Efeito dos compostos fenólicos presentes no alecrim (Rosmarinus officinalis L.) sobre as enzimas antioxidantes e os parâmetros bioquímicos do sangue de ratos diabéticos induzidos por estreptozotocina (OU) Efeito dos compostos fenólicos presentes no alecrim (Rosmarinus officinalis L.) sobre as enzimas antioxidantes e os parâmetros bioquímicos de ratos diabéticos induzidos por estreptozotocina." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-26092017-161242/.

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As ervas e especiarias são fontes de antioxidantes. Essa capacidade antioxidante está relacionada aos compostos fenólicos que apresentam papel importante nos processos de inibição da peroxidação e podem atuar sobre o estresse oxidativo, relacionado com diversas patologias, inclusive o diabetes. O alecrim é bastante apreciado por seu aroma e sabor, tendo como constituintes os seguintes compostos fenólicos: ácido carnósico, carnosol, ácido rosmarínico, ácido caféico e éster do ácido hidroxicinâmico. Objetivou-se avaliar a capacidade antioxidante in vitro de extratos e frações de ácidos fenólicos

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48

Björkehag, Jonathan, and Kristin Seglare. "Karolinska Testbädd för Telemedicin och eHälsa : En analys av medicintekniska företags behov och krav på en samverkansmiljö för produktutveckling på Karolinska Universitetssjukhuset." Thesis, Södertörns högskola, Institutionen för ekonomi och företagande, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-4828.

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Syftet med uppsatsen är att kartlägga behovet av en testbädd för telemedicinska produkter och att analysera krav som medicintekniska företag ställer på en testbäddsmiljö för samverkan med sjukvården. Målet har varit att konkretisera resultatet i en kommersialiseringsplan för Karolinska Testbädd för Telemedicin och eHälsa, vid Medicinsk Teknik på Karolinska Universitetssjukhuset. Vid genomförandet av undersökningen har totalt 19 intervjuer och ytterligare 6 telefonintervjuer genomförts med dels representanter från medicintekniska företag och sjukvården och dels med samarbetsstrukturer för medic

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49

Deans, BJ. "Isolation of plant natural products of potential chemotaxonomic significance and medicinal value." Thesis, 2019. https://eprints.utas.edu.au/32755/2/Deans_whole_thesis_ex_pub_mat.pdf.

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This thesis reports on the application of a rapid and simple pressurised hot water extraction (PHWE) method that utilises an unmodified household espresso machine to extract structurally-diverse natural products from plant material. The core focus of this thesis was the use of PHWE to expedite phytochemical screening of native Tasmanian and Australian plants and facilitate natural product isolation. The introduction features reviews on two key topics that are pertinent to the research described in this thesis. The first review summarises all natural product isolation studies of endemic Tasman

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50

Hsu, Chia-Yi, and 許家益. "Risk Management Introduction and Practical Application – New medicinal product manufactured in the pharmaceutical plant." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/6eza4k.

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碩士<br>元智大學<br>管理碩士在職專班<br>104<br>This Research is to discuss the new medicinal product manufactured in the pharmaceutical plant by introducing the concept and strategy of the Risk Management (RM) which consists of three modules, such as Risk assessment, Risk reduction and Persistent monitoring. Using these RM modules is the successful way to introduce the production of the new medicinal product. The PIC/s GMP (stands for Pharmaceutical Inspection Convention/scheme Good Manufacture Practice) regulation published by Taiwanese Food and Drug Administration (TFDA) is cited by this pharmaceutical-re

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