Journal articles: 'Medicinal Plants - drug effects'

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Saranya, K., V. Manivasagan, K. Gopi, and K. Karthik. "Broad-spectrum survey of medicinal plants as a potential source of anticancer agents." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 21, no. 1 (January 30, 2022): 1–40. http://dx.doi.org/10.37360/blacpma.22.21.1.01.

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Cancer is an abnormal and uncontrolled growth of cells that spreads through cell division. There are different types of medicines available to treat cancers, but no drug is found to be fully effective and safe for humans. The major problem involved in the cancer treatments is the toxicity of the established drug and their side effects. Medicinal plants are used as folk medicines in Asian and African populations for thousands of years. 60% of the drugs for treating cancer are derived from plants. More than 3000 plants have anticancer activity. The present review aims at the study of a broad spectrum survey of plants having anticancer components for different type of cancers. This article consists of 364 medicinal plants and their different parts as potential Source of Anticancer Agents.

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Gbeassor, M., Y. Kossou, K. Amegbo, C. De Souza, K. Koumaglo, and A. Denke. "Antimalarial effects of eight african medicinal plants." Journal of Ethnopharmacology 25, no. 1 (February 1989): 115–18. http://dx.doi.org/10.1016/0378-8741(89)90051-2.

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Maher, Tahani, Raha Ahmad Raus, Djabir Daddiouaissa, Farah Ahmad, Noor Suhana Adzhar, Elda Surhaida Latif, Ferid Abdulhafiz, and Arifullah Mohammed. "Medicinal Plants with Anti-Leukemic Effects: A Review." Molecules 26, no. 9 (May 7, 2021): 2741. http://dx.doi.org/10.3390/molecules26092741.

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Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient’s survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated. Effort has been made throughout this comprehensive review to highlight the recent developments and milestones achieved in leukemia therapies using plant-derived compounds and the crude extracts from various medicinal plants. Furthermore, the mechanisms of action of these plants are discussed.

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Setorki, Mahbubeh. "Medicinal herbs with anti-depressant effects." Journal of Herbmed Pharmacology 9, no. 4 (July 1, 2020): 309–17. http://dx.doi.org/10.34172/jhp.2020.39.

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Depression is a life-threatening chronic illness which affects people worldwide. Drugs used to treat this disease have multiple side effects and may cause drug-drug or drug-food interactions. Additionally, only 30% of patients respond adequately to the existing drugs and the remaining do not achieve complete recovery. Thus, finding effective treatments that have adequate efficacy, fewer side effects and lower cost seem to be necessary. The purpose of this study was to review animal and double-blind clinical studies on the anti-depressant effects of medicinal herbs. In this study, validated scientific articles indexed in PubMed, SID, Web of Science and Scopus databases were reviewed. A database search was performed using the following terms: clinical trials, depression, major depressive disorder, essential oil, extract and medicinal plant. Positive effects of a number of herbs and their active compounds such as St John’s-wort, saffron, turmeric, ginkgo, chamomile, valerian, Lavender, Echium amoenum and Rhodiola rosea L. in improvement of symptoms of mild, moderate or major depression have been shown in clinical trials. The above plants show antidepressant effects and have fewer side effects than synthetic drugs. Hence, they have the potential to treat patients with depression.

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Chhipa, Abu Sufiyan, and S. S. Sisodia. "Indian Medicinal Plants with Antidiabetic Potential." Journal of Drug Delivery and Therapeutics 9, no. 1 (January 15, 2019): 257–65. http://dx.doi.org/10.22270/jddt.v9i1.2282.

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Medicinal plants should be evaluated extensively to determine the active principles present in them that are responsible for the hypoglycemic activity of these plants. Herbal drugs have gained popularity among the general population due to their ability to treat ailments with minimum side effects. The multi-target approaches of medicinal plants make them least susceptible to failure during the treatment therapy. Medicinal plants showing prominent anti-diabetic activity during the initial studies should be further explored to identify the active principles present in them that can become the promising drug candidates for the disease treatment in the coming future. Keywords: Anti-diabetic, Diabetes Mellitus, Insulin, hypoglycemic, anti-hyperglycemic, anti-hyperlipidemic

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Ojetunde, A. O. "ANTIDIABETIC EFFECTS OF MEDICINAL PLANTS." Eastern Ukrainian Medical Journal 9, no. 1 (2021): 1–17. http://dx.doi.org/10.21272/eumj.2021;9(1):1-17.

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Diabetes is a chronic disorder that is characterized by an increase in blood glucose (hyperglycemia) with alteration of protein, carbohydrates, and fat metabolism. Consequently, it can lead to renal failure, atherosclerosis, nerve damage, blindness, and coronary heart disease. It is also known as the 5th leading cause of death. Although, there are numerous types of glucose-lowering drugs that exhibit anti-diabetic effects but results of treatment in patients are still not so perfect. Therefore, many treatments that include the use of medicinal plants are suggested and encouraged. Medical plants are believed to contain chemical substances with potential curative effects and can often have anti-diabetic effects. This study introduced about 23 effective medicinal plants reported by various experimental researchers with the curative potential to treat diabetes. Although, most of the research used animal models, there is a clear indication that medicinal plants with anti-diabetic potentials are being investigated by several researchers. However, there is a need for further research to be conducted with isolated bioactive ingredients present in these plants in order to have potential ingredients that could be used as a pharmacological agent in the treatment of diabetes mellitus with fewer adverse effects. Again, the mechanisms of action of these medicinal plants in ameliorating diabetes need to be investigated.

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Ilhan, Mert, Fatma Tuğçe Gürağaç Dereli, and Esra Küpeli Akkol. "Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis." Current Drug Delivery 16, no. 5 (May 29, 2019): 386–99. http://dx.doi.org/10.2174/1567201816666181227112421.

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Endometriosis is a disease in which the lining of the endometrium is found outside of the uterus. Recent medical treatments for endometriosis have adverse effects, limiting their long-term use. Furthermore, the recurrence of the disease after the cessation of therapy is quite common, and most patients need to continue treatment to maintain a hypoestrogenic environment till conception. Notwithstanding recent advances in computational and chemical practices, traditional medicines are considered the most consistent sources for the discovery of new drugs. Numerous medicinal plants and plantderived compounds have been tested against gynecological disorders, mainly endometriosis. This review aimed to describe the pharmacological activity profile of the medicinal plants and their active ingredients and draw attention to the discovery of multitargeted drug molecules for rational therapy.

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Shen, Yu-Li, Xiao-Qin Li, Rong-Rong Pan, Wei Yue, Li-Jun Zhang, and Hong Zhang. "Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms." Current Pharmaceutical Design 24, no. 26 (November 14, 2018): 3090–100. http://dx.doi.org/10.2174/1381612824666180911114810.

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Hair loss may not be recognized as a life-threatening disorder. However, it has a great harm to a person’s self-respect, mental health, and entirety quality of life. Androgenic alopecia (AGA) is the most common type of hair loss, which affects a great number of both men and women. Alopecia can be treated with various hair loss strategies, including hair transplant, cosmetics and medication. Medical treatment shows the outstanding ability in improving hair growth. Plenty of drugs prevents alopecia by inhibiting the secretion of male hormone. But these medicines exhibit some undesirable side effects. Since hair loss requires a long-term treatment and minimizing adverse side effects is extremely urgent in drug development. Accordingly, new agents are obtained from natural products with less adverse effects. Traditional Chinese medicines exhibit unique advantages in hair loss treatment. This review generalizes and analyzes the recent progress of medicinal plants for the treatment of hair loss, suggested mechanisms and outlines a number of trials taken or underway to optimize the treatment.

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Mustafa, Sodah Bint, Muhammad Akram, Hafiz Muhammad Asif, Imran Qayyum, Asif Mehmood Hashmi, Naveed Munir, Fahad Said Khan, Muhammad Riaz, and Saeed Ahmad. "Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice." Dose-Response 17, no. 2 (April 1, 2019): 155932581985250. http://dx.doi.org/10.1177/1559325819852503.

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Background: Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in patients with diabetes. The present study was conducted to explore the therapeutic potential of selected medicinal plants for the treatment of diabetes as an alternative to allopathic medicines. Method: In present study, hydroalcoholic extracts of Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and their polyherbal preparation (PHP) as compound drug were investigated for their antihyperglycemic potential in alloxan-induced diabetic mice. The study subjects (mice) were divided into different groups as normal control, diabetic control, pioglitazone treated (standard drug), test groups (plant extract treated 50, 100, and 150 mg/kg body weight), and PHP-treated group. Blood glucose concentration of all the study animals was determined by Glucose strip test. Qualitative phytochemical analysis of all the plant extracts was also performed following standard methods. Result: It was investigated that treatment of alloxan-induced diabetic mice with hydroalcoholic extracts of studied medicinal plants showed significant ( P < .05) effects on fasting blood glucose levels (from baseline to normal range) in a manner comparable to that of the reference drug, pioglitazone (1 mg/kg body weight intraperitoneal). The tested plant extracts significantly ( P < .05) reduced the glucose concentration in blood of diabetes-induced mice in a dose-dependent manner. Conclusion: It could be concluded that studied medicinal plants have antihyperglycemic activity. The study findings favor the use of traditional herbal medicinal practices for the management of diabetes that might due to the presence of bioactive phytoconstituents in plants. However, larger studies are required to identify, isolate, and characterize the bioactive phytoconstituents responsible for antihyperglycemic activity of studied medicinal plants.

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Ghanadi, Koroush, Afshin Hasanvand, Saber Abbaszadeh, Saeid Heidari-Soureshjani, and Tahra Suhan. "Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy." Plant Science Today 6, no. 2 (April 1, 2019): 114–22. http://dx.doi.org/10.14719/pst.2019.6.2.514.

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Chemotherapy induced-hepatotoxicity is one of the prevalent problems among cancer patients, with a wide spectrum of complications from liver dysfunction to liver necrosis. Therefore, in this study, we review the research findings on the effects of medicinal herbs and herbal compounds on the hepatotoxicity induced by anticancer drugs. The words hepatotoxicity and hepatoprotective along with the words cancer drug or chemotherapy in combination with some herbal terms such as medicinal plant, phyto* and herb* were used to search for relevant publications indexed in the Institute for Scientific Information (ISI) and PubMed. Available evidence shows that certain medicinal plants and herbal derivatives can reduce cancer drug-induced hepatotoxicity and protect liver cells against complications by regulating hepatic enzymes and increasing antioxidant enzyme activities. Some herbal formulations, including traditional Chinese medicine, have also been reported to exhibit such effects. Medicinal plants can exert anti-hepatotoxicity effects mainly by increasing antioxidant activity, inhibiting inflammatory processes, and reducing cell necrosis induced by anti-cancer drugs. Phytotherapy can be used as an effective complementary treatment for anticancer drug-induced hepatotoxicity and prevent various complications in the liver.

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Bahmani, Mahmoud, Mahmoud Mirhoseini, Hedayatollah Shirzad, Mehrnoosh Sedighi, Nejmeh Shahinfard, and Mahmoud Rafieian-Kopaei. "A Review on Promising Natural Agents Effective on Hyperlipidemia." Journal of Evidence-Based Complementary & Alternative Medicine 20, no. 3 (January 28, 2015): 228–38. http://dx.doi.org/10.1177/2156587214568457.

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Hyperlipidemia is a prevalent disease and a major component of the metabolic syndrome resulting from various factors. This disease increases morbidity and mortality when combined with other prevalent diseases such as diabetes mellitus, hypertension, and cardiovascular diseases. The side effects of the current lipid-lowering drugs have increased the tendency to move toward traditional and alternative treatments. Epidemiological observations indicate that using alternative treatments, consumption of medicinal plants, diet, and consumption of fruits have had satisfactory results on the effects of hyperlipidemia in many societies. It should be noted that in majority of societies, even developed countries, the tendency toward eating lipid-lowering medicinal plants has increased extensively. Using these plants especially when common remedies cannot control the disease is significant. Although consumption of medicinal plants by hyperlipidemic patients may show improvement in disease state, drug interaction and side effects may cause complications in disease control. Therefore, in this review, apart from introducing some of the reliable plants effective in inhibition and decrease of hyperlipidemia, the possibility of their intoxication and drug interaction is also presented.

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Jacobo-Salcedo, Maria del Rosario, Angel Josabad Alonso-Castro, Luis A. Salazar-Olivo, Candy Carranza-Alvarez, Luis Ángel González-Espíndola, Fabiola Domínguez, Sandra Patricia Maciel-Torres, et al. "Antimicrobial and Cytotoxic Effects of Mexican Medicinal Plants." Natural Product Communications 6, no. 12 (December 2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601234.

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The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

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Yesilada, E. "Novel drug leads from Turtkish medicinal plants with diverse pharmacological effects." Drugs of the Future 33, no. 8 (2008): 673. http://dx.doi.org/10.1358/dof.2008.033.08.1220137.

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Lam, Kit Ying, Anna Pick Kiong Ling, Rhun Yian Koh, Ying Pei Wong, and Yee How Say. "A Review on Medicinal Properties of Orientin." Advances in Pharmacological Sciences 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/4104595.

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Medicinal plants continue to play an important role in modern medications and healthcare as consumers generally believe that most of them cause fewer or milder adverse effects than the conventional modern medicines. In order to use the plants as a source of medicinal agents, the bioactive compounds are usually extracted from plants. Therefore, the extraction of bioactive compounds from medicinal plants is a crucial step in producing plant-derived drugs. One of the bioactive compounds isolable from medicinal plants, orientin, is often used in various bioactivity studies due to its extensive beneficial properties. The extraction of orientin in different medicinal plants and its medicinal properties, which include antioxidant, antiaging, antiviral, antibacterial, anti-inflammation, vasodilatation and cardioprotective, radiation protective, neuroprotective, antidepressant-like, antiadipogenesis, and antinociceptive effects, are discussed in detail in this review.

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Hussain, Kashif, Rao Zahid Abbas, Asghar Abbas, Muhammad Asif Raza, Muhammad Shahid Mahmood, Muhammad Imran, Muhammad Kasib Khan, and Muhammad Rafay. "Therapeutic potential of medicinal plants against Leishmaniasis: a public health concern." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 20, no. 2 (March 30, 2021): 123–31. http://dx.doi.org/10.37360/blacpma.21.20.2.10.

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Leishmaniasis is an important disease affecting global public health which is spread by sand fly having different species. Various chemical drugs are used to treat and control Leishmaniasis including pentavalent antimonials, antimicrobial and antibiotics. Due to emergence of drug resistance, these therapeutic options are losing effectiveness in attaining success. Furthermore, these drugs are expensive and have toxic effects on liver and kidneys. There has been an emerging interest and excellent response by using plant based drugs and extracts to control Leishmaniasis. Different medicinal plants including Glycyrrhiza glabra, Allium sativum, Peganum harmala and Nigella sativa have shown excellent anti-leishmanial activity. Therefore, medicinal plants can help in effective drug development against Leishmaniasis diseases in both animals and humans which will be safer and health protective.

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Maqbool, Mudasir, Imran Gani, and Mohmad Amin Dar. "ANTI-DIABETIC EFFECTS OF SOME MEDICINAL PLANTS IN EXPERIMENTAL ANIMALS: A REVIEW." Asian Journal of Pharmaceutical Research and Development 7, no. 1 (February 15, 2019): 66–69. http://dx.doi.org/10.22270/ajprd.v7i1.469.

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Diabetes is a chronic endocrine disease with global prevalence and increasing incidence. Diabetes presents with a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. In spite of drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on finding alternative modalities. By conducting sizable amount of analytical work, numerous traditional medicines have been found for diabetes. Substances and extracts isolated from completely different natural resources particularly plants have perpetually been a fashionable arsenal for dominant and treating polygenic disorders downside and complication arising because of it. Many medicinal plants have shown promising effects in experimental animals which can be extrapolated to humans also. In this paper, we will review various medicinal plants showing anti-diabetic activity in experimental animals.

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Sanusi, Shuaibu Babaji, Mohd Fadzelly Abu Bakar, Maryati Mohamed, Siti Fatimah Sabran, and Muhammad Murtala Mainasara. "Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–39. http://dx.doi.org/10.1155/2017/7185649.

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Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world’s population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants. Hence, this review is aimed at highlighting the medicinal plants of Southeast Asian origin evaluated for anti-TB. This review is based on literatures published in various electronic database. A total of 132 plants species representing 45 families and 107 genera were reviewed; 27 species representing 20.5% exhibited most significant in vitro anti-TB activity (crude extracts and/or bioactive compounds 0–<10 µg/ml). The findings may motivate various scientists to undertake the project that may result in the development of crude extract that will be consumed as complementary or alternative TB drug or as potential bioactive compounds for the development of novel anti-TB drug.

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Chomnawang, Mullika Traidej, Suvimol Surassmo, Veena S. Nukoolkarn, and Wandee Gritsanapan. "Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria." Journal of Ethnopharmacology 101, no. 1-3 (October 2005): 330–33. http://dx.doi.org/10.1016/j.jep.2005.04.038.

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Arefin, Paroma, Md Shehan Habib, Aishawarya Arefin, and Md Saidul Arefin. "Determination of potential sources of drug development for menstrual disorders: A qualitative analysis of published literature of in-vitro rat uterus experimental studies." International Journal of Pharmaceutical Chemistry and Analysis 8, no. 2 (July 15, 2021): 45–48. http://dx.doi.org/10.18231/j.ijpca.2021.010.

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Many herbal plants have been recorded in medicine for their usefulness in menstrual disorders, however, a few have been extensively examined for their pharmacological activities. These plants have been recorded to have usefulness in the management of painful menses, preventing miscarriages, prolonging birth, or inducing birth. Therefore, the effects of herbal plants on the contractility of the uterus will be investigated using the in-vitro experiment of the isolated rat uterus. The study aims to assess the most outstanding plants that are used to treat menstrual disorders, their uterine contractility properties, and adverse effects. The study will therefore acknowledge the importance of medicinal plants in the study of new drugs for regulating uterine contractility and propose suggestions for improving experiments involving medicinal plants on uterine contractility for drug development. The study will provide a direction as to whether the plant extract has drug development potential.

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Daoudi, Nour Elhouda, Mohamed Bouhrim, Hayat Ouassou, and Mohamed Bnouham. "Medicinal Plants as a Drug Alternative Source for the Antigout Therapy in Morocco." Scientifica 2020 (November 23, 2020): 1–10. http://dx.doi.org/10.1155/2020/8637583.

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Background. The gout is a metabolic disease that is associated with a high level of uric acid in the blood. This disease is treated with some medications that aim to reduce serum urate levels. However, the use of various medicines leads to the appearance of some side effects, hence the importance of using other treatments based on natural resources. Objective. This study presents some medical treatments, their side effects, and some plants that are used for gout management in Morocco in the aim to valorize them. Methods. We have been consulting various English publications in PubMed, Web of Science, and ScienceDirect published between 1991 and 2019 using the following keywords “drugs,” “gout,” “Morocco,” “medicinal plants,” “in vitro,” and “in vivo” terms. Then, we have classified the medicines, according to their action mechanisms, and we have cited some species that were reported in Moroccan pharmacopeia as antigout. Results. Three methods of the gout medical management were cited in this work: xanthine oxidase inhibitors, uric acid excretion enhancer, and uricase recombinant. However, it was found that these treatments had various side effects. We have described 23 species, and some of them showed experimentally an antigout effect by blocking the “xanthine oxidase” enzyme. These plants belong to 11 families. Lamiaceae represents the most dominant family with six species followed by Asteraceae with two species. Colchicine isolated from Colchicum autumnale is the most known compound for its efficiency towards gout. Conclusion. This work summarized different treatments particularly medicinal plants that are used in Morocco to treat gout disease by blocking uric acid secretion. However, several studies are needed to valorize these antigout natural sources.

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Chakraborty, Tania, and Santanu Paul. "Glinus oppositifolius (L.) Aug. DC.: A Repository of Medicinal Potentiality." International Journal of Phytomedicine 9, no. 4 (December 28, 2017): 543. http://dx.doi.org/10.5138/09750185.2164.

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Plants have been used in the treatment of human diseases since centuries. Due to their medicinal values, more than 80% of the modern world population still rely on plants as their primary source of medicines. Traditional plant-based medicines are widespread in Asian countries like the Indian subcontinent, Bangladesh, China, Japan, Pakistan, Indonesia, Myanmar, and in the continent of Africa. Nowadays, plant-derived medicines are gaining wider acceptance even in developed countries of the Western world. More than 50% of all drugs currently in clinical use are of natural origin. Plants are therefore emerging as a novel source for drugs and opening up new vistas in drug therapy research. A bird’s eye view of the therapeutic potential of the angiospermic plant Glinus oppositifolius (L.) Aug. DC. (Family: Molluginaceae) has been presented in this review, along with the ethnobotanical uses and scientific evidences presented in support of the traditional claims. Several pharmacologically active chemical compounds have been reported from the plant in recent years and the biological roles of those chemical compounds have been summarized. The anti-cancer effects shown by some of those phyto-constituents have also been elucidated. The novel chemical constituents reported from this plant may evoke further research on the plausible medicinal effects and the bio-safety standards of Glinus oppositifolius.

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Dereli, Fatma Tuğçe Gürağaç, Mert Ilhan, and Esra Küpeli Akkol. "New Drug Discovery from Medicinal Plants and Phytoconstituents for Depressive Disorders." CNS & Neurological Disorders - Drug Targets 18, no. 2 (March 18, 2019): 92–102. http://dx.doi.org/10.2174/1871527317666181114141129.

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Background & Objective: Depression, a risk factor for several serious diseases, is a highly prevalent and life-threatening psychiatric disorder. It can affect the individual’s position in life and reduce the living standards. The research on the use of medicinal plants in treating this disease has increased enormously because of the possible low rehabilitation rate and side effects of available synthetic drugs, such as sexual dysfunction, nausea, fatigue, insomnia, hypersomnia, and weight gain.Conclusion:Therefore, this review aimed to draw attention to the antidepressant effects of culinary herbs and traditional medicinal plants and their active components, thereby promoting their use in the development of more potent antidepressants with improved side effect profile.

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Teodor, Eugenia Dumitra, Veronica Moroeanu, and Gabriel Lucian Radu. "Lignans from Medicinal Plants and their Anticancer Effect." Mini-Reviews in Medicinal Chemistry 20, no. 12 (July 23, 2020): 1083–90. http://dx.doi.org/10.2174/1389557520666200212110513.

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Since early times, various plants have been used as remedies for treating different kinds of diseases and lesions with satisfying results. The phenolic compounds are secondary metabolites from medicinal plants which include a wide category of compounds such as phenolic acids, flavonoids, tannins, stilbenes, curcuminoids, xanthones, coumarins, lignans, etc. Between these, lignans are considered important in cancer prevention and treatment, besides other beneficial health effects, e.g. antioxidant, anticarcinogenic, antimutagenic, and anti-estrogenic effects. This review summarizes the most recent literature and the most important results concerning plant lignans and their derivatives in cancer prevention and treatment, both in vitro and in vivo assessments. The mechanistic aspects will be also highlighted.

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Ashwlayan, Dr Vrish Dhwaj, and Saurabh Nimesh. "Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis." Journal of Bone Biology and Osteoporosis 4, no. 1 (August 6, 2018): 43–50. http://dx.doi.org/10.18314/jbo.v4i1.1194.

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Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto immune disease, affecting people predominantly between the ages of 20-60 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. This is a long lasting disease that can affect joints in any part of the body, most commonly the hands, wrists, and knees. Popularity of medicinal plants is increasing day by day due to side effects of allopathic medicines. Herbal medicinal plants have been used as major sources of cure of human diseases since time immemorial. Today, one fourth of world population depends on traditional medicine and 80% of the population relies on indigenous herbal medicinal plants. Even today most of the people lives in different developing countries depend on the plant derived medicines for the first line of primary health care because of least or no side effects.

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Davoodvandi, Amirhossein, Roxana Sahebnasagh, Omid Mardanshah, Zatollah Asemi, Majid Nejati, Mohammad K. Shahrzad, Hamid R. Mirzaei, and Hamed Mirzaei. "Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects." Current Pharmaceutical Design 25, no. 30 (November 13, 2019): 3225–38. http://dx.doi.org/10.2174/1381612825666190829154934.

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Macrophages are one of the crucial mediators of the immune response in different physiological and pathological conditions. These cells have critical functions in the inflammation mechanisms that are involved in the inhibition or progression of a wide range of diseases including cancer, autoimmune diseases, etc. It has been shown that macrophages are generally divided into two subtypes, M1 and M2, which are distinguished on the basis of their different gene expression patterns and phenotype. M1 macrophages are known as pro-inflammatory cells and are involved in inflammatory mechanisms, whereas M2 macrophages are known as anti-inflammatory cells that are involved in the inhibition of the inflammatory pathways. M2 macrophages help in tissue healing via producing anti-inflammatory cytokines. Increasing evidence indicated that the appearance of different macrophage subtypes is associated with the fate of diseases (progression versus suppression). Hence, polarization of macrophages can be introduced as an important venue in finding, designing and developing novel therapeutic approaches. Albeit, there are different pharmacological agents that are used for the treatment of various disorders, it has been shown that several natural compounds have the potential to regulate M1 to M2 macrophage polarization and vice versa. Herein, for the first time, we summarized new insights into the pharmacological effects of natural compounds on macrophage polarization.

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Mulat, Mulugeta, Fazlurrahman Khan, Gizachew Muluneh, and Archana Pandita. "Phytochemical Profile and Antimicrobial Effects of Different Medicinal Plant: Current Knowledge and Future Perspectives." Current Traditional Medicine 6, no. 1 (January 8, 2020): 24–42. http://dx.doi.org/10.2174/2215083805666190730151118.

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The application of medicinal plants for combating various human ailments, as a food fortificant and additive have been adapted from ancient routine custom. Currently, developing countries use plants as a major source of primary health care. Besides, the emerging drug resistant pathogenic microbes encourage the utilization of medicinal plants as preeminent alternative sources of new bioactive substances. Extensive research findings have been reported in the last three decades. But methods to investigate the phytoconstituent and their biological effects are limited. This review contains brief explanations about the selection of medicinal plants, procedure for obtaining the crude as well as essential oil extracts, phytochemical screening, and in-vitro evaluation of antimicrobial activity. Furthermore, the antimicrobial activity of medicinal plant extracts reported from their respective solvent fractionated and non-fractionated in-vitro analysis has also been described in the present paper. The bioactive substances from medicinal plant along with chemical structure and biological effects are highlighted in the content.

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Ismail, Hammad, Muhammad Ammar Amanat, Adnan Iqbal, and Bushra Mirza. "Medicinal Plants: A Complementary and Alternative Antidepressant Therapy." Current Pharmaceutical Design 24, no. 22 (October 19, 2018): 2609–24. http://dx.doi.org/10.2174/1381612824666180727123950.

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There is enough data available now to believe that nature has provided cure of almost every ailment through herbal medicine or management. Therefore, now there is lot of emphasis on identification, evaluation, development and characterization of numerous plants and their active constituents against several diseases including depression. Depression is not only one of the most common ailments but also a highly complex condition to study. Even though several antidepressant drugs are available now, yet their effectiveness and usefulness are highly questionable especially because of their side effects. As herbal remedies are generally associated with favourable safety profiles therefore they have the possible potential to deliver effective replacements to currently available synthetic antidepressants. More recently, efforts have been focused on characterization of pharmacologically active ingredients and to identify the mode of action of herbal antidepressant medicines. This review describes a brief introduction of different animal models for depression and discusses the advantages and disadvantages for each approach. Then we have summarized possible plant phytochemicals as antidepressant drug and their underlying mechanisms. In the main body of the review, we have discussed in detail the most frequently used plants (21) being investigated for the treatment of depression. Additionally, we have provided the list of medicinal plants (92) representing their origin, parts used, extraction method, evaluation method and possible active ingredient. In the final part of the review we have presented the summary of clinical trials on the use of medical plants for depression and their active constituents.

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Okaiyeto, Kunle, and Oluwafemi O. Oguntibeju. "African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications." International Journal of Environmental Research and Public Health 18, no. 11 (June 2, 2021): 5988. http://dx.doi.org/10.3390/ijerph18115988.

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The African continent is naturally endowed with various plant species with nutritional and medicinal benefits. About 80% of the people in developing countries rely on folk medicines to treat different diseases because of indigenous knowledge, availability, and cost-effectiveness. Extensive research studies have been conducted on the medicinal uses of African plants, however, the therapeutic potentials of some of these plants has remained unexploited. Over the years, several studies have revealed that some of these African floras are promising candidates for the development of novel drugs. Despite the plethora of studies on medicinal plant research in Africa, there is still little scientific data supporting the folkloric claims of these plants. Besides, safety in the use of folk medicines has been a major public health concern over the year. Therefore, it has become mandatory that relevant authority should take measures in safeguarding the populace on the use of herbal mixtures. Thus, the present review extracted relevant information from different scientific databases and highlighted some problems associated with folk medicines, adverse effects on reproductive systems, issue about safety due to the toxicity of some plants and their toxicity effects with potential therapeutic benefits are discussed.

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Abouzekry, Sara S., Marwa T. Badawy, Nada M. Ezzelarab, and Ahmed Abdellatif. "Phytotherapy for diabetes mellitus; A review of Middle Eastern and North African folk medicinal plants." Journal of Herbmed Pharmacology 10, no. 1 (October 12, 2020): 1–13. http://dx.doi.org/10.34172/jhp.2021.01.

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Diabetes mellitus (DM) is considered as one of the most common metabolic disorders affecting huge number of people worldwide. Despite the availability of large numbers of drugs in the market to treat the disease, there is still a need for new sources to deal with the problem and avoid side effects. In the pursuit of discovering safer and more effective anti-diabetic drugs, herbal and folk medicine drugs from regions all over the world have captured researchers’ interest. Middle Eastern and North African medicinal plants contain a variety of pharmacologically active components that have shown to possess promising anti-diabetic potential. However, few data have been reported about medicinal plants from these regions in comparison to plants from other regions. Anti-diabetic medicinal plants from the MENA (the Middle East and North Africa) region, their role in controlling DM, and suggested mechanisms for the anti-diabetic activity of some medicinal plants are discussed in this review. Many of these plants have not been fully investigated and characterized, yet they have great potential for further development as anti-diabetic drugs.

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Saktiawan, Renny Agus, and Atmiasri Atmiasri. "PEMANFAATAN TANAMAN TOGA BAGI KESEHATAN KELUARGA DAN MASYARAKAT." Jurnal Abadimas Adi Buana 1, no. 2 (November 25, 2017): 57–64. http://dx.doi.org/10.36456/abadimas.v1.i2.a960.

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ABSTRACT Medicinal plants are a source of power that has existed since age-old. TOGA used by our ancestors in order to overcome health problems by making various ingredients of medicinal issues. Therefore the use of medicinal plant families or we called TOGA should be developed and circulated in the community, especially for all of households. But many people are still not aware of the utilization of family medicine. People often mistake them for the raw material too produce of traditional medicines and they do not understand yet how to process the material. It can cause side effects that are different for each person if given excessive doses of the drug. Health to our survival is very important, because without health we could not do any activities that can sustain our lifes. The method used observation and documentation. Medicinal plants are all kinds of plants that have their own uses as a medicine. Many parts of the plant can be used, such as the fruit, stems, leaves, and roots or tubers. Processing technology medicinal plants can be done by sorting, alteration, draining, and drying, storage, and so on. While herb processing can be done by grind, boil, and simmer. Keywords: Medicinal plants, TOGA, Benefits, and Processing.

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Khan, Ishfaq, and Azhar Khan. "MEDICINAL PLANTS AS ALTERNATIVE TREATMENTS FOR ORAL HEALTH PROBLEMS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (September 7, 2018): 58. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.24918.

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Oral flora plays an important role in the day-to-day life for human beings and also they are important part of human digestive system. Simultaneously, besides their beneficial activities, they can be harmful to the human, and this can be evaluated as normal oral flora as opportunistic pathogens. To elevate oral sanitation, medicinal plant-based mouthwash can be used as mediator and acts as a part of efficient home care medication. In dentistry, the importance of plants has been acknowledged to cure diseases generated by several oral pathogens. Chemical drugs possess many side effects and act as a key factor responsible for developing drug-resistant microorganisms. Herbal mouthwash products have fewer side effects than chemical drugs. The worldwide requirement for substitutive prevention, treatment choices, and products for oral infections that are harmless, efficient, and low cost comes from the boost in infection occurrence. For maintaining oral sanitation, ample research has been attempted to calculate the effect of plants. The review has established to aggregate the data on herbs and plants which possess great response to the pathogens concerned with oral infections. The review will assist the researchers to discover and choose the plant to develop adequate medicine for establishing cost-effective treatment for oral hygiene.

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Kumar, Ajay, Feroz Khan, and Dharmendra Saikia. "Exploration of Medicinal Plants as Sources of Novel Anticandidal Drugs." Current Topics in Medicinal Chemistry 19, no. 28 (December 19, 2019): 2579–92. http://dx.doi.org/10.2174/1568026619666191025155856.

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Background: : Human infections associated with skin and mucosal surfaces, mainly in tropical and sub-tropical parts of the world. During the last decade, there have been an increasing numbers of cases of fungal infections in immunocompromised patients, coupled with an increase in the number of incidences of drug resistance and toxicity to anti fungal agents. Hence, there is a dire need for safe, potent and affordable new antifungal drugs for the efficient management of candidal infections with minimum or no side effects. Introduction: : Candidiasis represents a critical problem to human health and a serious concern worldwide. Due to the development of drug resistance, there is a need for new antifungal agents. Therefore, we reviewed the different medicinal plants as sources of novel anticandidal drugs. Methods: : The comprehensive and detailed literature on medicinal plants was carried out using different databases, such as Google Scholar, PubMed, and Science Direct and all the relevant information from the articles were analyzed and included. Result: : Relevant Publications up to the end of November 2018, reporting anticandidal activity of medicinal plants has been included in the present review. In the present study, we have reviewed in the light of SAR and mechanisms of action of those plants whose extracts or phytomolecules are active against candida strains. Conclusion:: This article reviewed natural anticandidal drugs of plant origin and also summarized the potent antifungal bioactivity against fungal strains. Besides, mechanism of action of these potent active plant molecules was also explored for a comparative study. We concluded that the studied active plant molecules exhibit potential antifungal activity against resistant fungal strains.

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Okaiyeto, Kunle, UchechukwuU Nwodo, LeonardV Mabinya, and AnthonyI Okoh. "A review on some medicinal plants with hepatoprotective effects." Pharmacognosy Reviews 12, no. 24 (2018): 186. http://dx.doi.org/10.4103/phrev.phrev_52_17.

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Khosravian, Pegah, Saeid Heidari-Soureshjani, and Qian Yang. "Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review." Plant Science Today 6, no. 2 (April 1, 2019): 123–31. http://dx.doi.org/10.14719/pst.2019.6.2.513.

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Radiopharmaceuticals are drugs that contain radioisotopes used for diagnostic and therapeutic purposes. There are evidences that medicinal herbs and their constituents can modify the radiolabeling, biodistribution, and pharmacokinetics of radiopharmaceuticals through drug interaction. To have an overview of the effects and the underlying mechanisms of medicinal plants on the radiolabeling and bioavailability of radiopharmaceuticals, we conducted this study to summarize the current findings in this field. The scientific literature was systematically collected from databases and analyzed. Studies showed that medicinal plants and their constituents can alter radiolabeling and biodistribution via several mechanisms. Interactions with proteins in red blood cells at the same sites, chelating action of stannous and pertechnetate ions, antioxidant action impeding or decreasing stannous ion oxidation, direct oxidation of stannous ions, generation of reactive oxygen species (ROS) which oxidize stannous ions and damage induced in the cell membrane. Most the medicinal plants can decrease the radioactivity of radiopharmaceuticals, but some of them like Peumus boldus, Punica granatum, Nectandra membranacea, Mentha crispa, Rosmarinus officinalis and derivatives such as eugenol and epigallocatechin gallate have increasing effects. In addition, altering feature in some of them is tissue dependent.

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Lin, Chun-Ching, and Woei-Song Kan. "Medicinal Plants Used for the Treatment of Hepatitis in Taiwan." American Journal of Chinese Medicine 18, no. 01n02 (January 1990): 35–43. http://dx.doi.org/10.1142/s0192415x9000006x.

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In an extensive ethnobotanical survey of the folk medicines of Taiwan, 69 kinds of crude drugs and 107 species of medicinal plants were found to be used for hepatitis treatments. The present paper is to update a list of medicinal plants used in the treatment of hepatitis and evaluate their liver protection by ethnopharmacological and pathological studies. Results show that some of these drugs have prominent therapeutic effects. Further investigation regarding the anti-hepatotoxic principles will be made.

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Megersa, Moa, Tilahun Tolossa Jima, and Kabaye Kumela Goro. "The Use of Medicinal Plants for the Treatment of Toothache in Ethiopia." Evidence-Based Complementary and Alternative Medicine 2019 (August 20, 2019): 1–16. http://dx.doi.org/10.1155/2019/2645174.

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This paper presents a review of relevant medicinal plants used for toothache treatment in Ethiopia. This finding is based on a review of the literature published in scientific journals. A total of 130 medicinal plants, distributed in 117 genera and 62 families, are reported in the reviewed literature. Of the 130 species of medicinal plants reported in the literature, ninety-two (70.7%) were obtained from the wild whereas twelve (9.2%) were from home gardens. Shrubs (34.6%) were the primary source of medicinal plants, followed by herbs (30%). The Asteraceae came out as a leading family with 12 medicinal species while the Fabaceae followed with nine. Some findings include the predominance of root material used (31%), followed by leaves (29%). This study demonstrates the importance of traditional medicines in the treatment of toothache in Ethiopia. It is essential for the health of users to phytochemically demonstrate the effects of medicinal plants for their possible therapeutic applications. Hence, future phytochemical and pharmaceutical studies should give due consideration on frequently reported medicinal plants in order to produce natural drugs that could be effective in toothache treatment and without side effects.

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Sedighi, Mehrnoosh, Robert D. E. Sewell, Afshin Nazari, Saber Abbaszadeh, Mostafa Cheraghi, Abdolhakim Amini, Zahra Heydari, and Mahmoud Rafieian-Kopaei. "A Review on the Most Important Medicinal Plants Effective in Cardiac Ischemia-Reperfusion Injury." Current Pharmaceutical Design 25, no. 3 (May 30, 2019): 352–58. http://dx.doi.org/10.2174/1381612825666190329144016.

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: Ischemia, referring to reduction and restriction of perfusion to myocardial tissue which involves coronary artery through the formation of misplaced clots and thrombosis, is one of the most important cardiovascular diseases. Plant-based compounds help to improve or prevent disease by affecting the factors involved in the disease. This review was conducted to report the medicinal plants and factors effective in cardiac ischemiareperfusion (I/R) injury to supplement the knowledge about this disease and its prevention and treatment using certain medicinal plants and their active compounds. For this purpose, medicinal plants and their potential antioxidant activities, effects on lipid levels and plaque formation, atherosclerosis and development of cardiovascular diseases and ischemia were reviewed. Methods: To conduct this review, relevant articles published between 1983 and 2018 were retrieved from the Google Scholar, PubMed, Scientific Information Database, Web of Science, and Scopus using search terms antioxidant, ischemia, reperfusion, heart, infarct, inflammation, cholesterol and medicinal plants. Then, the eligible articles were reviewed. Results: The active compounds of plants, including phenolic compounds, flavonoids, and antioxidant compounds, can be effective on certain pathogenic factors particularly in decreasing cholesterol and blood pressure, preventing an increase in free radicals and ultimately reducing blood clots and vascular resistance to reduce and prevent ischemic disease and its harmful effects. Conclusion: Medicinal plants discussed in this article seem to be able to prevent cardiac damage and the disease progression via affecting the factors that are involved in ischemia.

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Gholipour, Sajedeh, Robert D. E. Sewell, Zahra Lorigooini, and Mahmoud Rafieian-Kopaei. "Medicinal Plants and Atherosclerosis: A Review on Molecular Aspects." Current Pharmaceutical Design 24, no. 26 (November 14, 2018): 3123–31. http://dx.doi.org/10.2174/1381612824666180911121525.

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Atherosclerosis is an inflammatory vascular disease that is characterized by progressive accumulation of cholesterol in the arterial walls and it is a major cause of cardiovascular disease. Issues related to the side effects of synthetic drugs have in recent times, led to the misuse of drugs, a lack of patient consultations, and consequently, a disruption in meticulous disease control. Therefore, a new insight into medicinal plants has recently emerged and much research has been conducted on these herbs in an attempt to prepare novel naturally based drugs. The aim of this review article was to scrutinize the molecular mechanisms of medicinal plants possessing effectiveness against atherosclerosis. To conduct the review, electronic searches were performed to retrieve potentially relevant publications, indexed within internet databases and reference textbooks concerning the effects and underlying molecular mechanisms of plants or their constituents used to treat atherosclerosis. Overall, medicinal plants facilitate atherosclerosis treatment through a variety of mechanisms which include the regulation of expression of inflammatory factors, stimulation of peroxisome proliferator-activated receptors (PPARs), inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), promotion of ATP-binding cassette transporter A1 (ABCA1) as well as ATP-binding cassette transporter G (ABCG), facilitation of adiponectin activity, reduction of sterol regulatory element-binding proteins (SREBPs) and antioxidant activity. An increased perception of these herbal mechanistic links is an important prelude to the design of novel plant based drugs.

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Gupta, K. K., G. Khandelwal, G. Prasad, A. K. Chopra, and A. Mishra. "A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems." Journal of Applied and Natural Science 2, no. 1 (June 1, 2010): 165–81. http://dx.doi.org/10.31018/jans.v2i1.116.

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Medicines obtained from drug plants and other sources are commonly called traditional medicines. They have played an important role in the treatment of several human diseases since ancient times. India possessed a great wealth of traditional health care system known as Ayurveda related to the use of plant species. The global market of herbal drugs has a great potential around the world. Demand of plant based medicines is also increasing among western countries because of a general consideration that most allopathic drugs are associated with more or less side effects. Many pharmaceutical companies are now manufacturing Ayurvedic phytopharmaceutical products. However, enough efforts have not been made to get suitable substitute of modern allopathic medicines from these traditionally used drug plants and herbal drugs. This traditional system of healthcare in India still needs extensive evidence-based scientific researches in promoting its therapies. This review paper deals with modern scientific approaches to find out new plant based molecules and to develop new technologies in a continuous process and should be applied in the practice to improve the quality of herbal drugs in Indian pharmaceutical industries. Critical assessment of quality assurance including researches on pharmacognosy, chemistry, pharmacology, antimicrobial activity and clinical studies carried out on various Ayurvedic medicinal plants are also being presented.

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Bahmani, Mahmoud, Naser Abbasi, Masih Hosseini, and Mahmoud Rafieian-Kopaei. "Concise review: Medicinal plants are effective against leishmaniasis." Biomedical Research and Therapy 4, no. 11 (November 29, 2017): 1775. http://dx.doi.org/10.15419/bmrat.v4i11.383.

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Leishmaniasis is an important zoonotic parasitic disease in tropical areas. It is a neglected disease and is a great health catastrophe in Iran. Pentavalent antimony compounds are used for its treatment, but they have adverse effects. Therefore, the use of natural herbs with low adverse effects seems necessary for treatment of Leishmaniasis. In this study, we tried to introduce the natural medicines effective against Leishmaniasis. In this review study, keywords searched included natural medicines, herbal medicines, medicinal plants, Leishmaniasis, and treatment in relevant publications published between 1990 and 2017. Searching was on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The relevant articles were reviewed for the review study. The results showed that medicinal plants: Ferula assafoatida (with IC50 of 0.38 mg/ml), Glycyrrhiza glabra (with IC50 of 25mg/ml), Allium sativum (with IC50 of 0.57 mg/ml), Cephalis ipecacuana (with IC50 of 0.01 mg/ml), Artemisia aucheri (with IC50 of 0.46 mg/ml) and Eucalyptus globulus (with IC50 of 0.17 mg/ml) were the natural medicines effective against the disease. Compositions with di-, tri-, tetra-Sulfide, Coumarin derivatives, Camuou-nephrole, Episamarcandine, Amblipernine, Carnephrole, Azafoetidine, Froxolicin, Azafoetidinole, Saradaferine, 1, 8 Cineole, Scopodreniole, Semen, Sabinine, Cineole, Inaleole, Eojenole, Farenzole, Borneol, Allicin, acid Glycerisic, Emetine and Cephalin can have the potential to produce potent drugs against Leishmaniasis. In sum, there are some specific medicinal plants and compounds effective against Leishmaniasis which can be used per se or following changes in their formula to prepare and introduce new drags against this disease.

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Khattak, Somia, Saeed-ur-Rehman, Hamid Ullah Shah, Waqar Ahmad, and Manzoor Ahmad. "Biological effects of indigenous medicinal plants Curcuma longa and Alpinia galanga." Fitoterapia 76, no. 2 (March 2005): 254–57. http://dx.doi.org/10.1016/j.fitote.2004.12.012.

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Ngamrojanavanich, Nattaya, Srinual Manakit, Surachai Pornpakakul, and Amorn Petsom. "Inhibitory effects of selected Thai medicinal plants on Na+,K+-ATPase." Fitoterapia 77, no. 6 (September 2006): 481–83. http://dx.doi.org/10.1016/j.fitote.2006.06.003.

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Vetriselvan Subramaniyan, Saminathan Kayarohanam, Ashok Kumar J, and Vinoth Kumarasamy. "Impact of herbal drugs and its clinical application." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (April 15, 2019): 1340–45. http://dx.doi.org/10.26452/ijrps.v10i2.537.

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Since ancient times until now exploring the importance of herbal medicines to treat the variety of diseases. Currently the herbal medicines searching for health, wellness and aim to achieve effective treatment without much side effect. Recent days the impact of herbal medicines well established even herbal treatment is one of the alternative medicines for most of the diseases such as hyperlipidemia, diabetes mellitus etc. Medicinal plants always have been rich sources of bioactive compounds, and that will be very helpful to human health. The reasons for herbal medicines attracted by the health care professionals and common individuals, including concern about confidence and safety of drugs. Allopathic medicines have many side effects and sometimes failing to treat and most of the herbal drugs proven better therapeutic effects without any major adverse effects. With the demand for phytomedicine user, this review highlights modern herbal drug formulation and its clinical use.

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Ebrahimi, Fatemeh, Mohammadali Torbati, Javad Mahmoudi, and Hadi Valizadeh. "Medicinal Plants as Potential Hemostatic Agents." Journal of Pharmacy & Pharmaceutical Sciences 23, no. 1 (February 6, 2020): 10–23. http://dx.doi.org/10.18433/jpps30446.

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Purpose: Medicinal plants with a variety of phytochemical ingredients remain a potential source for new drug discovery. The use of medicinal herbs in a wide range of diseases and symptoms, such as bleeding, is prevalent in traditional and ethno medicine worldwide. Thus, this work provides a comprehensive review of medicinal plants or their isolated compounds, with respect to their ethno-medicinal use, which have demonstrated the stimulating effect on the hemostasis process. Methods: The relevant studies were withdrawn from electronic databases including Pubmed, EMBASE and Web of Science with a structured search methodology. Results: The total of 17 medicinal plants with hemostatic activity were extracted. The most frequently studied plant families were Compositae, Lamiaceae, Fabaceae, and Asteraceae. Bioactive compounds exerting hemostatic activity included tannins, iridoid glycosides, glycoconjugate, lignan, saponins and phenolic compounds. The most attributed mechanisms include coagulation stimulation via increasing the factor XII activity and plasma fibrinogen levels, the fibrinolysis inhibition, vascular or smooth muscle constriction and platelet aggregation. The most important adverse effects of high dose extract or isolated compounds administration were hepatotoxicity and nephrotoxicity. Conclusion: This review provides a list of medicinal plants with hemostatic activity that could be used as valuable sources of new plant-based hemostatic agents. Furthermore, this could be practical in detecting possible interactions of plants with anticoagulant, antiplatelet, fibrinolytic and antifibrinolytic medications.

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Majeed, Wafa, Tanweer Khaliq, Bilal Aslam, Junaid Ali Khan, and Asra Iftikhar. "Medicinal plants with gastroprotective potential." Bangladesh Journal of Pharmacology 10, no. 3 (July 9, 2015): 588. http://dx.doi.org/10.3329/bjp.v10i3.23578.

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Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.

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Panda, Subhamay, and Leena Kumari. "Anti-Ophidian Properties of Herbal Medicinal Plants: Could it be a Remedy for Snake Bite Envenomation?" Current Drug Discovery Technologies 16, no. 4 (December 11, 2019): 319–29. http://dx.doi.org/10.2174/1570163815666180718095655.

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Snake bite envenoming causes high rates of morbidity and mortality and is one of the serious health-related concerns all over the globe. Around 3200 species of snakes have been discovered till date. Amid these species, about 1300 species of snakes are venomous. On account of its severity, World Health Organization (WHO) recently included snakebite envenoming in the list of neglected tropical diseases. Immunotherapy has partially solved the issues related to snakebite envenomation. However, it is associated with numerous adverse effects, due to which alternative treatment strategies are required for the treatment of snakebite. Traditionally, a large repository of herbal medicinal plants is known to possess activity against snake venom. An exploration of the therapeutic benefits of these medicinal plants used for the treatment of snakebites reveals the presence of various potential phytochemicals. The aim of the present review is to provide an outline regarding poisonous snakes all over the world, various compositions of snake venom, adverse effects related to anti-snake venom and numerous medicinal plants used for the anti-ophidian activity.

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Abbaszadeh, Saber, Parisa Arvin, and Mojtaba Khaksarian. "Neuroscience and herbal plants: A review on the most important herbal plants effective on chronic pain." Plant Science Today 6, no. 4 (October 1, 2019): 383–88. http://dx.doi.org/10.14719/pst.2019.6.4.572.

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Chronic pain can be periodic, persistent, or even a combination of both. Unlike acute pain, chronic pain is not usually useful, reduces the quality of life and functional abilities and also weakens mental health, interpersonal relationships, and financial status, leading to changes in appetite, sleep disorders, psychomotor retardation, tiredness and depression. Human being has always faced various kinds of pain during life and sought to relieve his pain. Pain is a sign of a disease that acts as a warning mechanism and informs of a tissue injury. In this regard, the analgesic effects of many medicinal plants have also been studied. Therefore, in this review study, indigenous medicinal plants with anti-chronic pain effects were reported. Information to conduct this review was obtained using the keywords chronic pain, herbal drug, Iran, medicinal plants, extracts and essential oils to retrieve articles indexed in databases such as Scopus, SID, Magiran, Google Scholar and other Persian databases. The related articles were reviewed for plants serving as chronic pain killers. After reviewing the literature, it was found that Solanum melongena, Hyoscyamus niger, Phoenix dactylifera, Cinnamomum zeylanicum, Artemisia sieberi, Crocus sativus, Carum copticum, Euphorbia helioscopia, Hypericum perforatum, Cucurbita maxima, Passiflora caerulea, Rosa damascena, Tanacetum parthenium, Allium jesdianum and Pistacia atlantica among indigenous medicinal plants with analgesic effect.

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Venieraki, A., M. Dimou, and P. Katinakis. "Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts." Hellenic Plant Protection Journal 10, no. 2 (July 26, 2017): 51–66. http://dx.doi.org/10.1515/hppj-2017-0006.

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SummaryMedicinal plants have been used for thousands of years in folk medicines and still are used for their health benefits. In our days medicinal plants are exploited for the isolation of plant-derived drugs as they are very effective and have relatively less or no side effects. However, the natural resources of medicinal plants are gradually exhausted and access to plant bioactive compounds is challenged by the low levels at which these products accumulate in native medicinal plants. For instance, to meet the market demands of 3 Kg per year of vinca alkaloids, powerful plant-derived anticancer drugs, 1.5×106Kg dry leaves are required. In this regard, this review aims to highlight the fact that endophytic fungi residing in medicinal plants are capable to biosynthesize pharmacologically active secondary metabolites similar or identical to those produced by their host medicinal plant. Furthermore, the evolutionary origin of the genes involved in these metabolic pathways as well as the approaches designed to enhance the production of these metabolites by the isolated endophytic fungi are also discussed.

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Seyedan, Atefehalsadat, Mohammed Abdullah Alshawsh, Mustafa Ahmed Alshagga, Sanaz Koosha, and Zahurin Mohamed. "Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/973143.

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Obesity is recognized as a major life style disorder especially in developing countries and it is prevailing at an alarming speed in new world countries due to fast food intake, industrialization, and reduction of physical activity. Furthermore, it is associated with a vast number of chronic diseases and disabilities. To date, relatively effective drugs, from either natural or synthetic sources, are generally associated with serious side effects, often leading to cessation of clinical trials or even withdrawal from the market. In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect. Pancreatic lipase inhibitory activity has been extensively used for the determination of potential efficacy of natural products as antiobesity agents. In attempts to identify natural products for overcoming obesity, more researches have been focused on the identification of newer pancreatic lipase inhibitors with less unpleasant adverse effects. In this review, we consider the potential role of plants that have been investigated for their pancreatic lipase inhibitory activity.

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Mathai, Bincy Mariyam, Manu M. Joseph, Santhi Maniganda, Jyothi B. Nair, J. S. Arya, Varsha Karunakaran, K. V. Radhakrishnan, and Kaustabh Kumar Maiti. "Guanidinium rich dendron-appended hydnocarpin exhibits superior anti-neoplastic effects through caspase mediated apoptosis." RSC Advances 6, no. 58 (2016): 52772–80. http://dx.doi.org/10.1039/c6ra08724h.

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Medicinal plants have truly demonstrated their potential as a repository of active biomolecules with promising therapeutic potential and represent an important source for the identification of novel drug leads.

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Journal articles on the topic 'Medicinal Plants - drug effects'

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