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Journal articles on the topic 'Mefenamic acid (MFA)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Hoque, Md Aminul, Anan Mahabub Aboni, Tasbira Jasmeen, and Sherejad Sanam. "Infrared Spectroscopic Study of Binding Interaction of Metal Complexes with Mefenamic Acid (MFA)." Journal of Pharmaceutical Research International 35, no. 2 (2023): 30–40. http://dx.doi.org/10.9734/jpri/2023/v35i27313.

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Aims: The foremost aim of this study was to evaluate the 1:1 formed complex when mefenamic acid interacts with Cu2+, Zn2+, and EDTA4- metal at the physiological condition, which provides a better understanding of the pharmacological studies. This research provided information on the binding affinity of mefenamic acid with selective metals. It helps with preparative, structural, and reactivity studies for multiple drug designs in pharmaceutical fields. Place and Duration of Study: Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh & CARS ((Centre for Advanced Re

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Yamazaki, Moe, Emi Shimamura, Takehisa Hanawa, and Yayoi Kawano. "Microparticulated Mefenamic Acid with High Dispersion Stability for Pediatric Dosage Form." Children 9, no. 6 (2022): 861. http://dx.doi.org/10.3390/children9060861.

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Mefenamic acid (MFA), a water-insoluble drug, is used as a suspension in the medical field, but it requires shaking before using to disperse MFA content in the suspension. In previous studies, trials to prepare MFA suspension with high dispersion stability by atomizing MFA by the wet-milling method. However, HPC is used for atomizing MFA. Therefore, the optimum concentration and molecular weight for atomizing MFA have not been investigated. In this study, we investigated the optimum molecular weight and concentration of HPC for the micronization of MFA. As a result, MFA particles became fine p

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3

Purwantoro, Dwi Utami, Ilma Nugrahani, and Slamet Ibrahim Surantaatmadja. "Studies of preparation, characterization, and solubility of mefenamic acid-nicotinamide co-crystal synthesized by using melt crystallization method." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 135. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.15863.

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Objective : The objective of this study is to develop the formation mefenamic acid (MFA) – nicotinamide (NCT) co-crystal by using melt crystallization method and investigate its solubility.Method : Co-crystal was prepared by using melt crystallization method of MFA-NCT (1:2) at (220±3) ° C. The initial co-crystal formation was performed by powder x-ray diffraction (PXRD). The thin layer chromatography (TLC) method was done to confirm the chemical stability of MFA and NCT due to synthesized process. The melt crystallization of MFA-NCT (1:2) was characterized by DSC/TG, Infrared spectrophotometr

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Dehghan, Tezerjani, Ali Benvidi, Masoud Rezaeinasab, Shahriar Jahanbani, and Ardakani Mazloum. "A nanostructured suitable platform based on multi wall carbon nanotubes and graphene nano sheets composite for determination of mefenamic acid." Journal of the Serbian Chemical Society 82, no. 11 (2017): 1273–86. http://dx.doi.org/10.2298/jsc161217043d.

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A mefenamic acid sensor was prepared by the modification of a glassy carbon electrode (GCE) with graphene nano-sheets (Gr) and multi wall carbon nanotubes (MWCNT). The designed sensor (MWCNT/Gr/GCE) indicated an electrocatalytic behaviour when applied for mefenamic acid (MFA) oxidation due to good conductivity, low electron transfer resistance and catalytic effect. The suggested sensor revealed a lower overvoltage and enhanced current compared with bare GCE for the oxidation of MFA. The observations indicated that the oxidation potential of MFA is decreased more than 200 mV using the designed

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Bukkitgar, S. D., N. P. Shetti, R. M. Kulkarni, and S. T. Nandibewoor. "Electro-sensing base for mefenamic acid on a 5% barium-doped zinc oxide nanoparticle modified electrode and its analytical application." RSC Advances 5, no. 127 (2015): 104891–99. http://dx.doi.org/10.1039/c5ra22581g.

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6

Lee, Wonseok, Yewon Mun, Kang-Yo Lee, et al. "Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage." Toxics 11, no. 9 (2023): 735. http://dx.doi.org/10.3390/toxics11090735.

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Mefenamic acid (MFA) is a commonly prescribed non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. MFA is known to have potent antioxidant properties and a neuroprotective effect against oxidative stress. However, its impact on the liver is unclear. This study aimed to elucidate the antioxidative effects of MFA and their underlying mechanisms. We observed that MFA treatment upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Treatment with various anthranilic acid derivative-class NSAIDs, including MFA, increased the expression o

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Ari Wahyudi, Dwi Utami, and Arif Budi Setianto. "The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer." Communications in Science and Technology 5, no. 2 (2020): 93–97. http://dx.doi.org/10.21924/cst.5.2.2020.213.

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Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by usin

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Nakka, Srinivas, Naresh Kumar Katari, Siva Krishna Muchakayala, Sreekantha Babu Jonnalagadda, and Surendra Babu Manabolu Surya. "A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method." RSC Advances 15, no. 3 (2025): 1957–69. https://doi.org/10.1039/d4ra08425j.

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The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of NDSRI impurities in mefenamic acid (MFA) tablet and pediatric suspension dosage forms.

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9

Hammood, Mohammad K., and Maryam Hamed. "Simultaneous Determination of Trace Mefenamic Acid in Pharmaceutical Samples via Flow Injection Fluorometry." International Journal of Drug Delivery Technology 10, no. 03 (2020): 395–401. http://dx.doi.org/10.25258/ijddt.10.3.16.

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Mefenamic acid belongs to non-steroidal anti-inflammatory drugs that are used widely for the treatment of analgesia. Our aim from this study is to establish a new assay for the quantitative determination of mefenamic acid (MFA) in the pharmaceutical sample by two sensitive and rapid flow injection-fluorometric methods. A homemade fluorometer was used in fluorescence measurements, which using solid-state laser diode 405 and 532 nm as a source, combined with a continuous flow injection technique. The first method depends on the effect of MFA on calcein blue (CLB) fluorescence at 405 nm. Another

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Sayyed Mudasar Hussain, Uzair Nisar, Kalpana Jeewnani, Muhammad Jamal, Shabana Usman Simjee, and Umbreen Farrukh. "Protective Effects of Mefenamic Acid against Pentylenetetrazol-Induced Seizures: An Experimental Study." RADS Journal of Pharmacy and Allied Health Sciences 2, no. 2 (2024): 19–26. https://doi.org/10.37962/jphs.v2i2.114.

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Background: Epilepsy is a chronic neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. Despite advancements in treatment, approximately 30% of patients remain unresponsive to current antiepileptic drugs (AEDs), highlighting the need for alternative therapies. Mefenamic acid (MFA), a nonsteroidal anti-inflammatory drug (NSAID), has shown potential anticonvulsant properties, possibly through modulation of GABAA receptors and adenosine signaling. Objective: This study aimed to evaluate the anticonvulsant effects of MFA in a pentylenetetrazol

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11

Mulchand, Shende*and Sakshi Agrawal. "SIMULTANEOUS ESTIMATION OF MEFENAMIC ACID AND HYOSCINE-N-BUTYL BROMIDE BY NOVEL RP-HPLC METHOD IN BULK AND PHARMACEUTICAL DOSAGE FORM." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3608–17. https://doi.org/10.5281/zenodo.1012170.

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A novel, precise, accurate, rapid and cost effective isocratic reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and subsequently validated for the estimation of Mefenamic acid and Hyoscine-N-Butyl bromide in the bulk and pharmaceutical dosage form. Separation was achieved on Inertsil ODS-3 column (250 × 4.6 mm, 5 μm) on Agilent HPLC 1260 system using potassium phosphate buffer (5 mM, pH 3.0): acetonitrile (25:75 v/v) as mobile phase and flow rate of 1 mL/min at 210.0 nm. The method was validated according to USP category I requirements. The system

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12

Adel, Islam, Qais Jarrar, Rami Ayoub, et al. "The Toxicity and Therapeutic Efficacy of Mefenamic Acid and its Hydroxyethyl Ester in Mice: In Vivo Comparative Study: A promising Drug Derivative." Jordan Journal of Pharmaceutical Sciences 15, no. 4 (2022): 507–22. http://dx.doi.org/10.35516/jjps.v15i4.674.

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Background: Hydroxyethyl Ester of Mefenamic acid (HEMA), which is an available derivative of mefenamic acid (MFA) in the literature, was shown to exert a strong resistance to enzymatic hydrolysis in various buffer solutions as well as in the plasma. However, there are no studies yet that investigate the biological effects of HEMA as a possible active drug in-vivo. This study provides an in-vivo investigation of the efficacy and toxicity of HEMA in comparison to those of a related drug, MFA, that has a similar chemical structure. Methods: Acute toxicity evaluations were conducted in vario

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13

Journal, Baghdad Science. "Mefenamic Acid Selective Membranes Sensor and Its Application to pharmaceutical Analysis." Baghdad Science Journal 13, no. 4 (2016): 829–37. http://dx.doi.org/10.21123/bsj.13.4.829-837.

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PVC membrane sensor for the selective determination of Mefenamic acid (MFA) was constructed. The sensor is based on ion association of MFA with Dodecaphospho molybdic acid (PMA) and Dodeca–Tungstophosphoric acid(PTA) as ion pairs. Nitro benzene (NB) and di-butyl phthalate (DBPH) were used as plasticizing agents in PVC matrix membranes. The specification of sensor based on PMA showed a linear response of a concentration range 1.0 × 10–2 –1.0 × 10–5 M, Nernstian slopes of 17.1-18.86 mV/ decade, detection limit of 7 × 10-5 -9.5 × 10 -7M, pH range 3 – 8 , with correlation coefficients lying betwee

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14

Ranjan, Subham, Ramesh Devarapalli, Sudeshna Kundu, et al. "Isomorphism: `molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid." IUCrJ 7, no. 2 (2020): 173–83. http://dx.doi.org/10.1107/s205225251901604x.

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The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA. The present study demonstrates the isomorphous nature of these compounds in a series of their multicomponent solids. Furthermore, the unique nature of MFA and TFA has been demonstrated while excavating their alternate solid forms in that, by varying the drug (MFA or TFA) to coformer [4-dimethylaminopyridine (DMAP)] stoichiometric ratio, both drugs have produced three different types

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15

Kopparapu, Venkata Nanda Kumar, Poornima Kasula, Ajay Kumar Reddy Ankinapalli, and M. Venkateswarlu. "RP-HPLC Method Development and Validation For Simultaneous Estimation of Paracetamol and Mefenamic Acid in Pharmaceutical Suspension." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 10, no. 04 (2019): 583–87. http://dx.doi.org/10.25258/ijpqa.10.4.4.

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Paracetamol (PCT) and Mefenamic acid (MFA), in combination, is recommended widely for the treatment of antipyretic and anti-inflammatory conditions. The present works carry a new simple, rapid, precise, accurate, and sensitized method of high-performance liquid chromatography with UV detection for simultaneous quantification of PCT and MFA. The samples are eluted in isocratic mode using a Phenomenex ODS 3V C18 (4.6mm × 250 mm i.d, with a particle size of 5μm) with the mobile composition of methanol: phosphate buffer pH 7.1 (70:30) delivered at a flow rate of 1ml/min with the detection waveleng

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16

Prasad, Elke, John Robertson, and Gavin W. Halbert. "An Additive Manufacturing MicroFactory: Overcoming Brittle Material Failure and Improving Product Performance through Tablet Micro-Structure Control for an Immediate Release Dose Form." Polymers 16, no. 18 (2024): 2566. http://dx.doi.org/10.3390/polym16182566.

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Additive manufacturing of pharmaceutical formulations offers advanced micro-structure control of oral solid dose (OSD) forms targeting not only customised dosing of an active pharmaceutical ingredient (API) but also custom-made drug release profiles. Traditionally, material extrusion 3D printing manufacturing was performed in a two-step manufacturing process via an intermediate feedstock filament. This process was often limited in the material space due to unsuitable (brittle) material properties, which required additional time to develop complex formulations to overcome. The objective of this

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17

El-Zaher, Asmaa Ahmed, Marianne Alphonse Mahrouse, and Ahmed Mohammed Al-Ghani. "Validated Chromatographic Methods for the Simultaneous Estimation of Etamsylate and Mefenamic Acid in the Presence of Their Main Impurities." Current Pharmaceutical Analysis 15, no. 6 (2019): 624–31. http://dx.doi.org/10.2174/1573412914666180423142911.

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Background: Etamsylate (ETS), a haemostatic drug, is formulated with mefenamic acid (MFA) for pain relief. Objective: The aim of this work was to develop chromatographic methods for the estimation of ETS and MFA in the presence of their main impurities. These methods could be used in the routine analysis in quality control laboratories. Methods: The first method was RP-HPLC method, the separation was carried out on an Inertsil® ODS- 3V C18 column using a mobile phase composed of acetonitrile: potassium dihydrogen phosphate buffer adjusted to pH 7 with 0.1 N NaOH (55: 45, v/v) at a flow rate of

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18

Nica, Mihaela-Alexandra, Valentina Anuța, Cristian Andi Nicolae, et al. "Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid." Pharmaceuticals 17, no. 10 (2024): 1316. http://dx.doi.org/10.3390/ph17101316.

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Objectives: The study explores the potential of various deep eutectic solvents (DESs) to serve as drug delivery systems and pharmaceutical excipients. The research focuses on two primary objectives: evaluating the ability of the selected DES systems to enhance the solubility of two poorly water-soluble model drugs (IBU and MFA), and evaluating their physicochemical properties, including density, viscosity, flow behavior, surface tension, thermal stability, and water dilution effects, to determine their suitability for pharmaceutical applications. Methods: A range of DES systems containing phar

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Al-Jemeli, Marwan, Mahmoud Abbas Mahmoud, Hasan Sh Majdi, Mohammad Fadhil Abid, Hiba M. Abdullah, and Adnan A. AbdulRazak. "Degradation of Anti-Inflammatory Drugs in Synthetic Wastewater by Solar Photocatalysis." Catalysts 11, no. 11 (2021): 1330. http://dx.doi.org/10.3390/catal11111330.

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Due to the high number of anti-inflammatory drugs (AIMDs) used by the public health sector in Iraq and distributed all over the country and due to their toxicity, there is a need for an environmental-friendly technique to degrade any wasted (AIMD) present in aquatic ecosystem. The degradation of diclofenac sodium (DCF), ibuprofen (IBN), and mefenamic acid (MFA) in synthetic hospital wastewater were investigated utilizing locally-made Cu-coated TiO2 nanoparticles in a solar-irradiated reactor. Different key variables were studied for their effects on process efficiency, such as loadings of cata

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Bonyadi, S., Kh Ghanbari, and M. Ghiasi. "All-electrochemical synthesis of a three-dimensional mesoporous polymeric g-C3N4/PANI/CdO nanocomposite and its application as a novel sensor for the simultaneous determination of epinephrine, paracetamol, mefenamic acid, and ciprofloxacin." New Journal of Chemistry 44, no. 8 (2020): 3412–24. http://dx.doi.org/10.1039/c9nj05954g.

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mpg-C<sub>3</sub>N<sub>4</sub>/PANI/CdO nanocomposite was electrochemically synthesized and used for simultaneous determination of EPI, PAR, MFA, and CIP. Also, HOMO and LUMO eigenvalues of the EPI, PAR, MFA and CIP molecules have been evaluated using the DFT method.

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Lee, Fatimah, Siti Nurul Ain Md Jamil, Nur Nida Syamimi Subri, Abel Adekanmi Adeyi, and Rusli Daik. "Sequestration of Doxycycline and Mefenamic Acid from Liquid Phase Using 1,3-Diaminopropane Modified Poly(Acrylonitrile-Acrylic Acid): Isotherm, Kinetic and Mechanism Studies." Sains Malaysiana 54, no. 1 (2025): 3687–704. https://doi.org/10.17576/jsm-2025-5401-18.

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Accumulation of pharmaceutical residues in aquatic environment due to daily consumption by humans and animals for diseases treatment results in alarming long-term effects. This study evaluates the adsorption potential of a polymer-based adsorbent, 1,3-diaminopropane-modified poly(acrylonitrile-acrylic acid) (DAP-poly(ACN/AA)), for the uptake of doxycycline (DOX) and mefenamic acid (MEFA) from aqueous solution. The chemical modification of poly(ACN/AA) copolymer with DAP was successful as suggested by the FTIR spectra and microanalysis results. The SEM analysis showed that the modified copolyme

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Abdulredha, Farah Haidar, Monther Faisal Mahdi, and Ayad Kareem Khan. "In silico molecular docking, ADME study and synthesis of new 1,3-diazetidin-2-one derivatives with high anti-proliferative activity." F1000Research 12 (September 1, 2023): 1090. http://dx.doi.org/10.12688/f1000research.138510.1.

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Background: Cancer and inflammation are strongly connected; tumor growth and spread are also greatly influenced by inflammation. Nitrogen-based heterocycle analogs are excellent suppliers of pharmaceuticals. Quaternary rings play a bigger role in drug development as bioactive scaffolds. For improved tolerance and synergistic benefits, heterocyclic nitrogen rings are present in many anticancer medications. Understanding how to bind to the EGFR and its prospective impacts on cancer cells, expect to construct new heterocyclic compounds that may help produce potent anticancer medicines with a high

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Tadić, Ana, Jelena Poljarević, Milena Krstić, et al. "Ruthenium–arene complexes with NSAIDs: synthesis, characterization and bioactivity." New J Chem 42, no. 4 (2018): 3001–19. https://doi.org/10.1039/c7nj04416j.

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Two non-steroidal antiinflammatory drugs indomethacin and mefenamic acid were coordinated to Ru(II)–arenes to afford four new complexes. The cytotoxic activities of the ligands and ruthenium complexes were tested in three human cancer cell lines (K562, A549, MDA-MB-231) and non-tumour human fetal lung fibroblast cells (MRC-5) by MTT assay. Cytotoxicity studies revealed that indomethacin Ru(II)–arene complexes 1 and 3 displayed good cytotoxicity and apparent cytoselective profiles. The IC50 values obtained in leukemia K562 cells were comparable to those of cisplatin (10.3 mM (CDDP),

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Halliwell, Robert F., Hamed Salmanzadeh, Leanne Coyne, and William S. Cao. "An Electrophysiological and Pharmacological Study of the Properties of Human iPSC-Derived Neurons for Drug Discovery." Cells 10, no. 8 (2021): 1953. http://dx.doi.org/10.3390/cells10081953.

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Human stem cell-derived neurons are increasingly considered powerful models in drug discovery and disease modeling, despite limited characterization of their molecular properties. Here, we have conducted a detailed study of the properties of a commercial human induced Pluripotent Stem Cell (iPSC)-derived neuron line, iCell [GABA] neurons, maintained for up to 3 months in vitro. We confirmed that iCell neurons display neurite outgrowth within 24 h of plating and label for the pan-neuronal marker, βIII tubulin within the first week. Our multi-electrode array (MEA) recordings clearly showed neuro

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Ashira, T. V., T. Mohamed Rafeeque, Saba Maanvizhi, S. Kathirvel, P. C. Indukala, and S. Safeetha. "Review for Analytical Methods for the Determination of Mefenamic Acid." Journal of Pharmaceutical Research International, September 15, 2021, 426–37. http://dx.doi.org/10.9734/jpri/2021/v33i43b32572.

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Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus

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Jarrar, Qais, Rami Ayoub, Said Moshawih, Yazun Jarrar, and Jamal Jilani. "Synthesis and Biological Evaluation of Hydroxypropyl Ester of Mefenamic Acid as a Promising Prodrug." Letters in Drug Design & Discovery 19 (March 30, 2022). http://dx.doi.org/10.2174/1570180819666220330160134.

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Background: The free carboxylic acid group present in the mefenamic acid (MFA) structure plays a potential role in developing various neuromuscular side effects after MFA administration. In this study, the hydroxypropyl promoiety was added to the carboxylic acid group of MFA in an attempt to reduce the neuromuscular side effects of MFA and improve its therapeutic effects. Methods: Hydroxypropylester of MFA (HPEMA) was synthesized and subjected to various in vivo investigations compared to MFA. The neuromuscular toxicity was conducted following high doses administration in mice and was evaluate

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DARAJI, NEELKUMAR K., VIPUL P. PATEL, and VINODKUMAR D. RAMANI. "FORMULATION OPTIMIZATION AND CHARACTERIZATION OF AQUEOUS INJECTION CONTAINING POORLY SOLUBLE DRUG USING MIXED HYDROTROPIC SOLUBILIZATION." International Journal of Current Pharmaceutical Research, September 15, 2021, 100–107. http://dx.doi.org/10.22159/ijcpr.2021v13i5.1908.

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Objective: Mefenamic acid (MFA) is an NSAID that exhibits anti-inflammatory analgesic and antipyretic activity. Peak plasma levels are attained in 2-4 h and the elimination half-life approximates 2 h, repetitive administration of tablets for 3-5 times a day is desired. It is supplied only in the form of tablets for oral administration. In acute conditions drug administered parenterally could give rapid relief from severe symptoms like pain. Thus, formulation of injectable formulation of MFA could be better alternative compared to conventional tablet dosage form. The low aqueous solubility of M

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Khansari, Parto S., Sonali S. Shaligram, Roshanak Rahimian, and Robert F. Halliwell. "Abstract 11673: Neuroprotective Mechanisms of Mefenamic Acid in an in vitro Model of Stroke." Circulation 134, suppl_1 (2016). http://dx.doi.org/10.1161/circ.134.suppl_1.11673.

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Introduction: Fenamates are classical non-steroidal anti-inflammatory drugs but they are also modulators of GABA A receptors, activators of potassium channels and antagonists of non-selective cation channels. Previous data from our lab has demonstrated that the fenamate, mefenamic acid (MFA), has neuroprotective effects both in vitro and in vivo . Hypothesis: We hypothesized that the neuroprotective actions of mefenamic acid result from its diverse pharmacological properties. To test this hypothesis, we have investigated four pharmacological properties of MFA, namely cyclooxygenase (COX) inhib

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Amooshahi, Parvaneh, Sadegh Khazalpour, Ameneh Amani, and Hossein Masoumi. "Green electrochemical method for the synthesis of nitro and azo derivatives based on mefenamic acid." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-05009-0.

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AbstractElectrochemical study of mefenamic acid (MFA) was carried out with details in water/ethanol mixture by the various voltammetric techniques. The results showed that the oxidation of MFA is highly dependent on pH and follows the Eir mechanism. The EpA1-pH diagram plotted based on the differential pulse voltammograms shows two linear segments, 66 and 26 mV/pH slope. Also, the diffusion coefficient and the surface excess, Ӷ* of MFA in aqueous buffered solution, determined by using the single potential-step chronoamperometry and chronocoulometry methods. Electrochemical nitration of MFA in

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Dominguini, Diogo, Monique Michels, Leticia B. Wessler, Emilio L. Streck, Tatiana Barichello, and Felipe Dal-Pizzol. "Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis." Journal of Neuroinflammation 19, no. 1 (2022). http://dx.doi.org/10.1186/s12974-022-02616-6.

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AbstractThe pathophysiology of sepsis may involve the activation of the NOD-type receptor containing the pyrin-3 domain (NLPR-3), mitochondrial and oxidative damages. One of the primary essential oxidation products is 8-oxoguanine (8-oxoG), and its accumulation in mitochondrial DNA (mtDNA) induces cell dysfunction and death, leading to the hypothesis that mtDNA integrity is crucial for maintaining neuronal function during sepsis. In sepsis, the modulation of NLRP-3 activation is critical, and mefenamic acid (MFA) is a potent drug that can reduce inflammasome activity, attenuating the acute cer

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"The Efficacy and Safety of Leard-Ngam Remedy Powder versus Mefenamic Acid for Relieving Primary Dysmenorrhea." Journal of the Medical Association of Thailand 107, no. 11 (2024): 902–9. http://dx.doi.org/10.35755/jmedassocthai.2024.11.902-909-00883.

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Background: Primary dysmenorrhea refers to uterine contractions and pain during menstruation. Leard-ngam remedy (LG) is listed as a Thai Herbal Medicine Product for the treatment of the menstrual period. Objective: To study the efficacy and side effects of LG compared with mefenamic acid (MFA) for reducing menstrual pain in primary dysmenorrhea. Materials and Methods: A randomized controlled trial was conducted at Thammasat University Hospital in women diagnosed with primary dysmenorrhea. The numerical rating scale (NRS) was used for the pain score assessment, which was scaled from 0 to 10. Th

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Kumar, Sanjeev, Chander Parkash, Pradeep Kumar, and Shailendra Kumar Singh. "APPLICATION OF SOME NOVEL TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF MEFENAMIC ACID, A POORLY WATER SOLUBLE DRUG." International Journal of Pharmaceutical Sciences and Drug Research, October 3, 2009, 164–71. https://doi.org/10.25004/ijpsdr.2009.010306.

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Mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug (NSAID), has a low oral bioavailability due to poor aqueous solubility and insufficient dissolution. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and melt mixing. The formulations were characterised by differential scanning calorimetry (DSC) and X-Ray powder diffractometry (XRD) and were investigated for drug content studies, solubility studies, in vitro study and in vivo e

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Zali, Fatemeh, Majid Dadmehr, Mohsen Bahrami, Ali Ghobadi, Maryam Kashanian, and Elham Akhtari. "A Comparison of the Effect of Ajwain (Trachyspermum ammi (L.) Sprague) and Mefenamic Acid for Alleviating the Symptoms of Primary Dysmenorrhea: An Open-Label Randomized Controlled Trial." Traditional and Integrative Medicine, June 27, 2023. http://dx.doi.org/10.18502/tim.v8i2.13078.

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Trachyspermum ammi (L.) Sprague (commonly known as ajwain) contains ingredients that attenuate menstrual problems, especially cramping. In this study, we evaluated the impact of ajwain on the pain intensity in a sample of Iranian female college students with primary dysmenorrhea (PD) in comparison to mefenamic acid (MFA). This study was an open-label, randomized, parallel-group clinical trial conducted in the university dormitories in Tehran, Iran, from September 2018 to May 2019. Seventy patients were randomly assigned to two groups of ajwain and MFA. The participants in the ajwain group were

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VandenAkker, Natalie E., Stefano Vendrame, Panagiotis Tsakiroglou, and Dorothy Klimis-Zacas. "Red raspberry (Rubus idaeus) consumption restores the impaired vasoconstriction and vasorelaxation in the aorta of the obese zucker rat, a model of the metabolic syndrome." Journal of Berry Research, November 24, 2020, 1–13. http://dx.doi.org/10.3233/jbr-200567.

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Metabolic Syndrome (MetS) increases the risk of cardiovascular disease. Whole red raspberry (WRR) consumption on vascular function was investigated in the obese Zucker rat (OZR), model of MetS. Male OZR and their lean littermates (LZR) were placed on a control (C) or an 8% w/w WRR-enriched diet for 8 weeks. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (Ach)-induced vasorelaxation were measured in aortic rings in the presence or absence of L-N-monomethyl-arginine (L-NMMA) and mefenamic acid (MFA). Phe-induced vasoconstriction was lower in the OZR-C compared to LZR-C (p < 0.

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Mohd.Yunis, Saleem Bhat, Iftikhar Shapoo Dheeraj Sharma a. Moin, and Zargar Atoofa. "EFFICACY OF LOCALISED APPLICATION OF TRANEXEMIC ACID AND MEFENAMIC ACID TABLET POWDER IN EXTRACTION SOCKETS FOR CONTROL OF POST EXTRACTION BLEEDING AND PAIN:A SPLIT-MOUTH RANDOMIZED CONTROLLED CLINICAL TRIAL." June 28, 2023. https://doi.org/10.5281/zenodo.8199182.

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<strong>Background</strong>: Post extraction bleeding and pain are two common complications in routine dental practice .There are no studies in which Tranexamic acid and Mefenamic acid combination powder is used locally to control post extraction bleeding and pain. <strong>Methodology</strong>: This study was conducted in 18 patients indicated for orthodontic extraction of mandibular first premolar and  right side was the study side in which pre crushed TRANSET MF powder was placed and compared to the left side which was the control side .Post extraction bleeding immediately and 30 m

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