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Dissertations / Theses on the topic 'Mefloquine. Malaria'

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1

Karbwang, J. "Clinical pharmacology of mefloquine." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234865.

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2

Kitchener, Scott. "Evaluation of safety and adverse effects of mefloquine in the chemoprophylaxis of Malaria in non-immune Australian soldiers /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16419.pdf.

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3

Holmes, Katelyn. "Cytotoxicity and Functional Toxicity of Mefloquine and the Search for Protective Compounds." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801913/.

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Mefloquine hydrochloride is an antimalarial agent that has been used for the past 40 years. Numerous reports of neurological side effects have recently led the FDA to issue a strong warning regarding long-term neurological effects. This warning lead to the U.S. Army’s Special Forces and other components to discontinue its use in July of 2013. Despite reported adverse side effects, mefloquine remains in circulation and is recommended to travelers going to specific Asian countries. Mefloquine has been used as a treatment for those already infected with the malaria parasite (blood concentratio
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4

Langley, Natasha. "Preclinical evaluation of the possible enhancement of the efficacy of anti-malarial drugs by pheroid technology / Natasha Langley." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1521.

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5

Van, Huyssteen Este. "Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology / E. van Huyssteen." Thesis, North-West University, 2010. http://hdl.handle.net/10394/5050.

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Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which translate to low bioavailability. Mefloquine is eliminated slowly with a terminal elimination half-life of approximately 20 days and has neuropsychiatric side effects. Novel drug delivery systems have been utilised to optimise chemotherapy with currently available antimalarial drugs. Pheroid™ technology is a patented drug delivery system which has the ability to capture, tra
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6

Basson, Eldrian. "The prevalence of malaria in Mefloquine hydrochloride - mefliam ® users during the deployment of military forces in Burundi, East Africa." Thesis, Bloemfontein : Central University of Technology, Free State, 2007. http://hdl.handle.net/11462/87.

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Thesis (M. Tech.) - Central University of Technology, Free State, 2007<br>Malaria and the mosquito that induces the disease in humans have hounded the military for decades. Malaria represents one of the most important infectious disease threats to deployed military forces. Malaria in soldiers has a serious economic impact, both in terms of lost productivity and treatment cost for the state. A contingent of South African National Defence Force members has been deployed in Burundi since November 2001, as part of a peacekeeping mission. At the time of the study no information was available regard
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7

Slabbert, Chrizaan. "Evaluation and validation of methods to determine parasitemia in malaria cell cultures / Chrizaan Slabbert." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2332.

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8

Wessels, Johanna Christina. "International pharmacopoeia monographs : antimalarial dosage forms / J.C. Wessels." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4920.

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Malaria is a disease affecting millions of people in 109 malarious countries and territories, causing approximately one million deaths annually. In 2004 one of the parasites causing human malaria, Plasmodium falciparum, was among the leading global causes of death from a single infectious agent, especially in Africa (WHO, 2008:23). Treatment of this disease with single active pharmaceutical ingredients has led to the emergence of resistant P. falciparum parasites, resulting in the most severe form of this illness. Alarmingly, the poor quality of commercially available antimalarial products, es
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9

Ghavami, Maryam. "Antimalarial Agents: New Mechanisms of Actions for Old and New Drugs." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96192.

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Worldwide, malaria is one of the deadliest diseases. In 2016 it sickened 216 million people and caused 445,000 deaths. In order to control the spread of this deadly diseases to human, we can either target the mosquito vector (Anopheles gambiae) or the parasite (Plasmodium falciparum). Due to recent emergence of resistance to current insecticides and antimalarial drugs there is a pressing need to discover and develop new agents that engage new targets in these organisms. To circumvent the effect of resistance to pyrethroid insecticides on the efficacy of insecticide treated nets (ITNs), the us
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10

Guimarães, Matheus Murmel. "Utilização de carboidratos e derivados na preparação de grupos conectores para síntese de antimaláricos multifuncionais." reponame:Repositório Institucional da UFPR, 2016. http://hdl.handle.net/1884/45784.

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Orientador : Prof. Dr. Alan Guilherme Gonçalves<br>Coorientador : Prof. Dr. Diogo R. B. Ducatti<br>Coorientador : Prof. Dr. Roberto Pantarolo<br>Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba, 25/02/2016<br>Inclui referências : f. [121-139]<br>Área de concentração: Insumos, medicamentos e correlatos<br>Resumo: Uma doença de longo histórico existencial, a malária é uma parasitose que ainda coloca diversas regiões do mundo em risco, ocasionando milhares de mortes. A Organização Mundial de
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11

Sihuincha, Maldonado Moisés Guido, and Prado Eduardo Demetrio Matos. "Estudio de la eficacia terapéutica del tratamiento artesunato - mefloquina para malaria por Plasmodium falciparum no grave en Loreto." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2007. https://hdl.handle.net/20.500.12672/11874.

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El documento digital no refiere asesor<br>Determina la eficacia del esquema de tratamiento antimalárico combinado de artesunato más mefloquina contra la malaria por Plasmodium falciparum no complicado en la región de Loreto, Perú. Determina la respuesta parasitológica y clínica de pacientes con malaria por P. falciparum no complicada al nuevo esquema de tratamiento artesunato más mefloquina. Determina el nivel de resistencia inicial del P. falciparum a las drogas artesunato y mefloquina. Busca conocer la tasa del efecto gametocida del artesunato en el esquema de tratamiento artesunato más mefl
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12

Müller, Edgar. "Untersuchungen zur simultanen Gabe von Artesunat und Mefloquin in der Behandlung der unkomplizierten Plasmodium falciparum - Malaria in Afrika und Südostasien /." Regensburg : Roderer, 2008. http://d-nb.info/99081016X/04.

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13

Müller, Edgar. "Untersuchungen zur simultanen Gabe von Artesunat und Mefloqiun [Mefloquin] in der Behandlung der unkomplizierten Plasmodium falciparum - Malaria in Afrika und Südostasien." Regensburg Roderer, 2007. http://d-nb.info/99081016X/04.

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14

Ventura, Marcielle Teixeira. "Emulsões pediátricas de artesunato associado com cloridrato de mefloquina no tratamento da malária: desenvolvimento e estudo de estabilidade." Niterói, 2017. https://app.uff.br/riuff/handle/1/3350.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-17T18:14:43Z No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>Made available in DSpace on 2017-04-17T18:14:43Z (GMT). No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>A Malária é uma doença tropical muito importante em saúde pública devido às altas taxas de morbidade e mortalidade no mundo. Essa doença ocorre principalmente nas regi
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15

Fürstenau, Moritz Alexander Verfasser], and Peter [Akademischer Betreuer] [Kremsner. "Wirksamkeit von Mefloquin als intermittierende präventive Behandlung der Malaria in der Schwangerschaft gegen Schistosoma haematobium-Infektionen in Gabun / Moritz Alexander Fürstenau ; Betreuer: Peter Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1197694935/34.

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16

Fürstenau, Moritz [Verfasser], and Peter [Akademischer Betreuer] Kremsner. "Wirksamkeit von Mefloquin als intermittierende präventive Behandlung der Malaria in der Schwangerschaft gegen Schistosoma haematobium-Infektionen in Gabun / Moritz Alexander Fürstenau ; Betreuer: Peter Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1197694935/34.

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17

Teixeira, Manuel João Moutinho. "Profilaxia da Malária em Viajantes." Master's thesis, 2016. http://hdl.handle.net/10316/37017.

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Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de infecciologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.<br>Imported malaria is still a major public health issue. Despite the personal protection measures have an important role in malaria prevention, it remains dependent on chemoprophylaxis. There must be a distinction between prophylaxis of P.falciparum malaria and malaria caused by relapsing species, such as P.vivax. Prophylaxis of falciparum malaria is hindered by increased resistance to drugs and the high cost of some medic
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18

Kurth, Florian Michael [Verfasser]. "Pharmacokinetic characteristics of two paediatric formulations of Artesunate-Mefloquine in African children with acute uncomplicated plasmodium falciparum Malaria / vorgelegt von Florian Michael Kurth." 2009. http://d-nb.info/992638615/34.

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19

Bélard, Sabine Miriam [Verfasser]. "Efficacy, safety, tolerability and acceptability of two pediatric formulations of artesunate-mefloquine in African children with acute uncomplicated Plasmodium falciparum malaria / vorgelegt von Sabine Miriam Bélard." 2008. http://d-nb.info/987985221/34.

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20

Van, der Watt Abel Hermanus. "Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination / Abel Hermanus van der Watt." Thesis, 2014. http://hdl.handle.net/10394/10809.

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Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached disturbingly high levels in South-East Asia and on the African continent. Consequently, there is a dire need for new drugs or formulations in the prophylaxis and treatment of malaria. Artesunate, an artemisinin derivative, represents a new category of antimalarials that is effective against drug-resistant Plasmodium falciparum strains and is of significance in the current antim
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