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Journal articles on the topic 'Megakaryoblast'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Terui, T., Y. Niitsu, K. Mahara, et al. "The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis." Blood 75, no. 7 (1990): 1540–48. http://dx.doi.org/10.1182/blood.v75.7.1540.1540.

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Abstract Acute myelofibrosis is often associated with acute megakaryoblastic leukemia (AMKBL). Although the exact mechanism for the progression of myelofibrosis in AMKBL is unclear, certain humoral factors from megakaryoblastic cells, the precursors of platelets, may be involved in the enhancement of collagen synthesis by bone marrow fibroblasts. The present study, therefore, is an investigation of the possible pathogenic role of transforming growth factor-beta (TGF-beta), known to be a very potent collagen-stimulating factor found in platelets in the myelofibrosis of AMKBL. The results obtain

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2

Terui, T., Y. Niitsu, K. Mahara, et al. "The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis." Blood 75, no. 7 (1990): 1540–48. http://dx.doi.org/10.1182/blood.v75.7.1540.bloodjournal7571540.

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Acute myelofibrosis is often associated with acute megakaryoblastic leukemia (AMKBL). Although the exact mechanism for the progression of myelofibrosis in AMKBL is unclear, certain humoral factors from megakaryoblastic cells, the precursors of platelets, may be involved in the enhancement of collagen synthesis by bone marrow fibroblasts. The present study, therefore, is an investigation of the possible pathogenic role of transforming growth factor-beta (TGF-beta), known to be a very potent collagen-stimulating factor found in platelets in the myelofibrosis of AMKBL. The results obtained were a

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3

Dorn, G. W., M. G. Davis, and D. D. D'Angelo. "Gene expression during phorbol ester-induced differentiation of cultured human megakaryoblastic cells." American Journal of Physiology-Cell Physiology 266, no. 5 (1994): C1231—C1239. http://dx.doi.org/10.1152/ajpcell.1994.266.5.c1231.

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Platelet protein makeup is determined during transformation of megakaryoblasts to mature megakaryocytes, the immediate precursor of circulating platelets. To better understand the molecular mechanisms of megakaryocyte formation, gene expression was characterized by Northern analysis and RNA fingerprinting of cultured human CHRF-288 megakaryoblastic cells undergoing phorbol ester-stimulated megakaryocytic differentiation or serum-stimulated megakaryoblast proliferation. Protooncogenes c-fos and c-jun were coordinately upregulated in both proliferating and differentiating cells, whereas c-myc tr

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4

Michiels, Jan J., M. Eric Prins, Anne Hagermeijer, et al. "Philadelphia Chromosome–Positive Thrombocythemia and Megakaryoblast Leukemia." American Journal of Clinical Pathology 88, no. 5 (1987): 645–52. http://dx.doi.org/10.1093/ajcp/88.5.645.

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5

Vuurst, Hans van der, Maaike Hendriks, Eduardo G. Lapetina, Gijsbert van Willigen та Jan-Willem N. Akkerman. "Maturation of Megakaryoblastic Cells Is Accompanied by Upregulation of GSα-L Subtype and Increased cAMP Accumulation". Thrombosis and Haemostasis 79, № 05 (1998): 1014–20. http://dx.doi.org/10.1055/s-0037-1615112.

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SummaryIn platelets and megakaryoblasts Gs, the trimeric G-protein that stimulates adenylyl cyclase, is present in a short, 45 kDa, and a long, 52 kDa isoform termed Gsα-S and Gsα-L, respectively. To assess the relative contribution of these isoforms in the cellular synthesis of cAMP, the ratio Gsα-S/Gsα-L was changed in the megakaryoblastic cell line DAMI by inducing cell maturation with recombinant human thrombopoietin (TPO) or the phorbol ester PMA. Flow cytometric analysis confirmed that this treatment induced a moderate (TPO) and extensive (PMA) increase in nuclear ploidy and expression o

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6

Guimaraes-Sternberg, Cinthya, Ari Meerson, Iftach Shaked, and Hermona Soreq. "MicroRNA modulation of megakaryoblast fate involves cholinergic signaling." Leukemia Research 30, no. 5 (2006): 583–95. http://dx.doi.org/10.1016/j.leukres.2005.09.005.

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7

Prakisya, Nurcahya Pradana Taufik, Febri Liantoni, Puspanda Hatta, Yusfia Hafid Aristyagama, and Andika Setiawan. "Utilization of K-nearest neighbor algorithm for classification of white blood cells in AML M4, M5, and M7." Open Engineering 11, no. 1 (2021): 662–68. http://dx.doi.org/10.1515/eng-2021-0065.

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Abstract Acute myeloid leukemia (AML) M4, M5, and M7 are subtypes of leukemia derived from myeloid cell derivatives that influences the results of the identification of AMLs, which includes myeloblast, monoblast, and megakaryoblast. Furthermore, they are divided into more specific types, including myeloblasts, promyelocytes, monoblasts, promonocytes, monocytes, and megakaryoblasts, which must be clearly identified in order to further calculate the ratio value in the blood. Therefore, this research aims to classify these cell types using the K-nearest neighbor (KNN) algorithm. Three distance me

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8

Suljević, D., A. Hamzić, E. Islamagić, E. Fejzić, and A. Alijagić. "Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow." BULGARIAN JOURNAL OF VETERINARY MEDICINE 24, no. 1 (2021): 22–31. http://dx.doi.org/10.15547/bjvm.2019-0063.

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This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure analysis. Five main types of thrombocyte precursor cells were identified in the bone marrow samples: megakaryoblast, promegakaryocyte and megakaryocyte (basophilic, acidophilic and thrombocytogenic). More intensive thrombopoiesis and morphologically differentiated cells were found in sternum samples.

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9

van Oorschot, Rinske, Anna E. Marneth, Marten Hansen, et al. "Megakaryocyte Expansion and Platelet CD34 Expression Observed in GFI1BQ287*-Related Bleeding and Platelet Disorder Is Caused By Quenching of the Lysine Specific Demethylase LSD1/KDM1A." Blood 128, no. 22 (2016): 363. http://dx.doi.org/10.1182/blood.v128.22.363.363.

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Abstract The heterozygous Q287* mutation in Growth Factor Independence 1B (GFI1B) causes an autosomal-dominant bleeding disorder characterized by gray platelets as a result of reduced α-granule content.Affected individuals also exhibited macro-thrombocytopenia, increased megakaryocyte numbers and platelet CD34 expression. GFI1B functions as transcriptional repressor by recruiting the histone modifying enzyme LSD1/KDM1A. The C-terminally truncated GFI1B-Q287* mutant has lost its repressive function and inhibits the function of wild type GFI1B in a dominant-negative manner. To study how mutant G

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10

Terpstra, Willem E., Otger J. A. T. Meuwissen, Anne Hagemeijer, and Jan J. Michiels. "Multiple Myeloma and Acute Megakaryoblast Leukemia in Spent Phase Polycythemia Vera." American Journal of Clinical Pathology 94, no. 6 (1990): 786–90. http://dx.doi.org/10.1093/ajcp/94.6.786.

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11

Ciocea, Alieta, Tatiana V. Byzova, and Michael Kalafatis. "Role of Casein Kinase 2 in Platelets Release from Megakaryocytes." Blood 108, no. 11 (2006): 1534. http://dx.doi.org/10.1182/blood.v108.11.1534.1534.

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Abstract Megakaryoblasts are precursors of platelets. Megakaryoblasts first differentiate to the stage of megakaryocytes. Megakaryocytes mature by increasing their size and by undergoing nuclear endoreplication and cytoplasmic maturation. Mature megakaryocytes form pseudopodia and reach pro-platelet bearing stage. Proplatelets bearing megakaryocytes fragment to give rise to platelets, through the process of thrombocytopoiesis. Both the thrombocytopoiesis and the megakaryocytopoiesis processes are linked to the constitutive apoptosis of megakaryocytic cells. The BCR/ABL oncoprotein is the resul

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12

Allen, RJ, SD Smith, RL Moldwin, et al. "Establishment and characterization of a megakaryoblast cell line with amplification of MLL." Leukemia 12, no. 7 (1998): 1119–27. http://dx.doi.org/10.1038/sj.leu.2401002.

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13

Hassan, H. T., S. Grell, U. Borrmann-Danso, and M. Freund. "Interleukin-4 inhibits proliferation of human leukemic megakaryoblast cell line mhh 225." Hematological Oncology 12, no. 2 (1994): 61–66. http://dx.doi.org/10.1002/hon.2900120203.

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14

Wong, K. F., and P. H. Yu. "Erythrophagocytic megakaryoblasts in acute megakaryoblastic leukaemia." British Journal of Haematology 148, no. 5 (2010): 672. http://dx.doi.org/10.1111/j.1365-2141.2009.07839.x.

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15

Denis Solomons, Hilary. "Acute Megakaryoblastic Leukaemia and Retinal Vein Thrombosis." Cancer Research and Cellular Therapeutics 8, no. 7 (2024): 01–03. https://doi.org/10.31579/2640-1053/216.

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16

Trivedi, Pina J., Dharmesh M. Patel, Mahnaz M. Kazi, Priya K. Varma, and Archana B. Patel. "Pediatric Acute Megakaryoblast Leukemia & Down Syndrome -An Experience of A Single Institute." Medical & Clinical Case Reports Journal 1, no. 2 (2023): 24–28. http://dx.doi.org/10.51219/mccrj/pina-j-trivedi/07.

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17

AMEMIYA, NORIHIKO, YUTAKA YATOMI, MITSUAKI YANAGI, TAKESHI ENDO, and YUKIO OZAKI. "Mixed Blast Crisis of Chronic Myelogenous Leukemia Involving Minimally Differentiated Myeloblast and Megakaryoblast Lineages." Laboratory Hematology 10, no. 4 (2004): 254–55. http://dx.doi.org/10.1532/lh96.04024.

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18

Сергеева, Е. А., А. А. Метелкин, and А. А. Соколовская. "Expression of cell cycle cyclins in human megakaryoblast cell line exposed to simulated microgravity." Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» 67, no. 2 (2023): 17–25. http://dx.doi.org/10.25557/0031-2991.2023.02.17-25.

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Актуальность. Исследования, выполненные в невесомости, показали, что космический полет вызывает серьезные физиологические изменения в живом организме. В клетках млекопитающих микрогравитация способна индуцировать и модулировать протекание таких ключевых процессов, как апоптоз, пролиферация, миграция и адгезия. Несмотря на возросший интерес к космической биологии и медицине, исследования клеточного цикла в условиях микрогравитации остаются спорными. Цель исследования – изучение экспрессии циклинов клеточного цикла клеток мегакариобластного лейкоза человека при воздействии моделированной микрогр

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19

Elagib, Kamaleldin E., Lorrie L. Delehanty, and Adam Goldfarb. "A Murine Model for the Transient Myeloproliferative Disorder of Down Syndrome: Phenotypic Influence of p53 on Reversible Megakaryoblastic Disorder." Blood 112, no. 11 (2008): 688. http://dx.doi.org/10.1182/blood.v112.11.688.688.

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Abstract Infants with Down syndrome (DS) display a high incidence of a reversible megakaryoblastic proliferation known as transient myeloproliferative disorder (DS-TMD). The clinical features of DS-TMD include marrow and liver infiltration by abnormal megakaryoctic precursors. These cells show a high propensity for spontaneous death, leading to liver damage and occasionally tumor lysis syndromes. Rapid disease onset is followed by gradual spontaneous remission over weeks to months. 10–20% of patients experience disease recurrence, which manifests as irreversible acute megakaryoblastic leukemia

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20

Sunami, S., A. Fuse, B. Simizu, et al. "The c-sis gene expression in cells from a patient with acute megakaryoblastic leukemia and Down's syndrome." Blood 70, no. 2 (1987): 368–71. http://dx.doi.org/10.1182/blood.v70.2.368.368.

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Abstract The c-sis gene expression in leukemia cells from a patient with acute megakaryoblastic leukemia and Down's syndrome was studied. The leukemia blasts were identified as megakaryoblasts by the platelet peroxidase reaction and the reactivity against antiplatelet monoclonal antibodies. Leukemia cells obtained from peripheral blood or bone marrow specimens before and after initiation of chemotherapy were analyzed for c-sis gene expression by the RNA-DNA dot blot hybridization. Although the level varied, the mRNA of the c-sis gene was detected in all megakaryoblastic leukemia cells obtained

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21

Sunami, S., A. Fuse, B. Simizu, et al. "The c-sis gene expression in cells from a patient with acute megakaryoblastic leukemia and Down's syndrome." Blood 70, no. 2 (1987): 368–71. http://dx.doi.org/10.1182/blood.v70.2.368.bloodjournal702368.

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The c-sis gene expression in leukemia cells from a patient with acute megakaryoblastic leukemia and Down's syndrome was studied. The leukemia blasts were identified as megakaryoblasts by the platelet peroxidase reaction and the reactivity against antiplatelet monoclonal antibodies. Leukemia cells obtained from peripheral blood or bone marrow specimens before and after initiation of chemotherapy were analyzed for c-sis gene expression by the RNA-DNA dot blot hybridization. Although the level varied, the mRNA of the c-sis gene was detected in all megakaryoblastic leukemia cells obtained at diffe

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22

Sokolovskaya, Alisa A., Ekaterina A. Sergeeva, Arkadiy A. Metelkin, Mikhail A. Popov, Irina A. Zakharova, and Sergey G. Morozov. "The Expression of Cell Cycle Cyclins in a Human Megakaryoblast Cell Line Exposed to Simulated Microgravity." International Journal of Molecular Sciences 25, no. 12 (2024): 6484. http://dx.doi.org/10.3390/ijms25126484.

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The study of the physiological and pathophysiological processes under extreme conditions facilitates a better understanding of the state of a healthy organism and can also shed light on the pathogenesis of diseases. In recent years, it has become evident that gravitational stress affects both the whole organism and individual cells. We have previously demonstrated that simulated microgravity inhibits proliferation, induces apoptosis, changes morphology, and alters the surface marker expression of megakaryoblast cell line MEG-01. In the present work, we investigate the expression of cell cycle

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23

PEHLİVAN, Melek, and Hakkı Ogün SERCAN. "Megakaryoblast ve bazofil hücre tipine sahip Ph (+) KML hücre hatlarının Wnt ve Frizzled ilişkili gen ifadelerinin karşılaştırılması." Cukurova Medical Journal 46, no. 1 (2021): 318–24. http://dx.doi.org/10.17826/cumj.795833.

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24

Nakata, Masanori, Ikuro Maruyama, and Toshihiko Yada. "Leptin potentiates ADP-induced [Ca2+]i increase via JAK2 and tyrosine kinases in a megakaryoblast cell line." Diabetes Research and Clinical Practice 70, no. 3 (2005): 209–16. http://dx.doi.org/10.1016/j.diabres.2005.03.036.

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25

Bombery, Melissa, and Jo-Anne Vergilio. "Transient Abnormal Myelopoiesis in Neonates: GATA Get the Diagnosis." Archives of Pathology & Laboratory Medicine 138, no. 10 (2014): 1302–6. http://dx.doi.org/10.5858/arpa.2014-0304-cc.

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Transient abnormal myelopoiesis occurs exclusively in patients with Down syndrome (constitutional trisomy 21), manifests in the neonatal period, and is characterized by circulating megakaryoblasts with varied degrees of multisystem organ involvement. In most cases, this process resolves spontaneously by 3 to 6 months of age, but for some, the disease can be fatal. Affected patients are particularly prone to develop acute megakaryoblastic leukemia in early childhood. Somatic GATA1 mutations are believed to be pivotal in the development of transient abnormal myelopoiesis and have proven to be a

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26

Soniran, O. T., O. A. Idowu, O. L. Ajayi, and I. C. Olubi. "Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice." Malaria Research and Treatment 2012 (June 24, 2012): 1–7. http://dx.doi.org/10.1155/2012/960758.

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The aim of the present study was to investigate the positive influence of chloroquine and artesunate on the pathological damages caused by Plasmodium berghei on vital organs of mice in an established infection. Healthy adult albino mice with average weight of 25 g were used for the study. Treated group was administered orally with 100 mg/kg of chloroquine and artesunate, respectively. Control animals were given water for the same period. Histological examination of the liver, spleen, lungs, and kidney revealed absence of accumulation of iron (haemosiderosis) in the liver, thickened alveolar wa

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27

Brach, MA, B. Lowenberg, L. Mantovani, U. Schwulera, R. Mertelsmann, and F. Herrmann. "Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts." Blood 76, no. 10 (1990): 1972–79. http://dx.doi.org/10.1182/blood.v76.10.1972.1972.

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Abstract We have examined the in vitro effects of recombinant human (rh) interleukin-1 (IL-1) on the growth of purified megakaryoblasts obtained from patients with acute megakaryoblastic leukemia. We demonstrate that both IL-1 alpha and IL-1 beta treatment of these cells led to stimulation of DNA synthesis (as shown by increase of 3H-thymidine incorporation up to 35-fold) and also resulted in colony formation of leukemic megakaryoblasts. However, the stimulatory effect of IL-1 was dependent on endogenous production of IL-6, because addition of neutralizing monoclonal antibody (MoAb) to IL-6 ab

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28

Brach, MA, B. Lowenberg, L. Mantovani, U. Schwulera, R. Mertelsmann, and F. Herrmann. "Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts." Blood 76, no. 10 (1990): 1972–79. http://dx.doi.org/10.1182/blood.v76.10.1972.bloodjournal76101972.

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We have examined the in vitro effects of recombinant human (rh) interleukin-1 (IL-1) on the growth of purified megakaryoblasts obtained from patients with acute megakaryoblastic leukemia. We demonstrate that both IL-1 alpha and IL-1 beta treatment of these cells led to stimulation of DNA synthesis (as shown by increase of 3H-thymidine incorporation up to 35-fold) and also resulted in colony formation of leukemic megakaryoblasts. However, the stimulatory effect of IL-1 was dependent on endogenous production of IL-6, because addition of neutralizing monoclonal antibody (MoAb) to IL-6 abrogated t

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29

Suci Widyastiti, Nyoman, Ima Arum Lestarini, Yetty Movieta Nancy, Umi S Intansari, and R. Lindeman. "LEUKEMIA MEGAKARIOBLASTIK AKUT PADA SEORANG ANAK." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 14, no. 2 (2018): 77. http://dx.doi.org/10.24293/ijcpml.v14i2.906.

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Acute Megakaryoblastic Leukemia (FAB AML M7) occurs in all age groups with two peaks in distribution. The one is in adults and theother in children 1 to 3 years of age especially in those with Down’s syndrome. The diagnosis of AML M7 requires more than 30% of thenucleated bone marrow cells being megakaryoblasts. The AML M7 was under diagnosed before the availability of monoclonal antibodies.The more common types of AML MO-M6 have to be excluded by morphological and cytochemical analysis whereas immunology is neededto exclude ALL. The megakaryocytic nature of the leukemia has to be proven by ul

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30

Messick, J., M. Carothers, and M. Wellman. "Identification and Characterization of Megakaryoblasts in Acute Megakaryoblastic Leukemia in a Dog." Veterinary Pathology 27, no. 3 (1990): 212–14. http://dx.doi.org/10.1177/030098589002700314.

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31

El-Mohandes, E., and F. G. J. Hayhoe. "5-NUCLEOTIDASE ACTIVITY OF MEGAKARYOBLASTS IN A CASE OF ACUTE MEGAKARYOBLASTIC LEUKAEMIA." British Journal of Haematology 53, no. 3 (2008): 523–26. http://dx.doi.org/10.1111/j.1365-2141.1983.00503.x-i1.

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32

Guminski, Alexander, Paul Harnett, and Anna deFazio. "Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line - a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia." Cancer Chemotherapy and Pharmacology 48, no. 3 (2001): 229–34. http://dx.doi.org/10.1007/s002800100279.

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33

Page, Elyse C., Susan L. Heatley, Paul Q. Thomas, and Deborah L. White. "Inducible Knockout of HMGN1 in an In Vivo xenograft Model Reduces Down Syndrome Leukemic Burden and Increases Survival Outcomes." Blood 136, Supplement 1 (2020): 25. http://dx.doi.org/10.1182/blood-2020-138620.

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Introduction Down Syndrome (DS) patients are at high risk of developing hematological malignancies and ~10% are born with a pre-leukemic disorder characterised by the overproduction of immature megakaryoblasts. Children with DS have a 20-fold increased risk of developing acute lymphoblastic leukemia (ALL) of which 60% are associated with high expression of cytokine receptor like factor 2 (CRLF2) and of these, ~9% acquire the aggressive CRLF2 p.F232C mutation. DS-ALL children also experience high treatment toxicity and high relapse rates compared to non-DS leukemia patients. Genes on chromosome

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34

Lechman, Eric R., Karin G. Hermans, Stephanie M. Dobson, et al. "Modeling the Multi-Step Pathogenesis of Acute Myeloid Leukemia of Down Syndrome." Blood 124, no. 21 (2014): 3579. http://dx.doi.org/10.1182/blood.v124.21.3579.3579.

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Abstract The multistep pathogenesis of Down Syndrome (DS)-associated pre-leukemia and subsequent progression to acute leukemia is one of the better characterized of all human blood malignancies. Children with DS have a 150 fold increased risk of developing acute megakaryoblastic leukemia (AMKL) and greater than 30 fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). DS-AMKL is often preceded in late fetal development or soon after birth by a pre-leukemic syndrome termed transient myeloproliferative disorder (TMD), which is characterized by high numbers of abnormal meg

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35

Ratnaningsih, Tri, and Aji Bagus Widyantara. "ACUTE MEGAKARYOBLASTIC LEUKEMIA (AML-M7) IN 10-MONTH-OLD BABY BOY WITH DOWN SYNDROME." Biomedika 14, no. 1 (2022): 90–98. http://dx.doi.org/10.23917/biomedika.v14i1.15062.

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ABSTRAKLeukemia megakarioblastik akut (acute megakaryoblastic leukemia, AML-M7) merupakan subtipe AML dengan mayoritas megakarioblas. Kejadian AML-M7 umumnya terjadi pada anak-anak dengan down syndrome. Bayi laki-laki berusia 10 bulan dengan down syndrome rujukan dari RSU PKU Muhammadiyah Yogyakarta datang dengan keterangan klinis prolonged fever suspek keganasan akut hematologi seri mieloid. Pemeriksaan tanda vital nadi 102x/menit, suhu 36,7oC pernafasan 30x/menit. Pemeriksaan fisik: berat badan 7,1 kg, tinggi badan 66,1 cm. Hepar teraba 6 cm bawah arcus costae, limpa Schuffner II. Pemeriksaa

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Rainis, Liat, Esther Rosenthal, Sabine Strehl, Oskar A. Haas, and Shai Izraeli. "The ERG Gene in Normal and Malignant Megakaryopoiesis." Blood 104, no. 11 (2004): 3431. http://dx.doi.org/10.1182/blood.v104.11.3431.3431.

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Abstract About 10% of patients with Down syndrome (DS) are born with a transient megakaryoblastic leukemia. We (Rainis et al. Blood2003; 102:981) and others have demonstrated acquired intrauterine inactivating mutations in the X-linked gene GATA1 in these leukemias. The gene(s) on chromosome 21 that promote the proliferation of these abnormal megakaryoblasts are presently unknown. We hypothesize such a role to the ets transcription factor ERG that is located at the critical DS region on chromosome 21. This hypothesis is based on the close homology between ERG and FLI-1, a transcription factor

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37

Zunino, Rodolfo, Qinggang Li, Sergio Daniel Rosé, et al. "Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of plateletlike particles and inhibits proliferation and tumorigenesis." Blood 98, no. 7 (2001): 2210–19. http://dx.doi.org/10.1182/blood.v98.7.2210.

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Rapid proliferation of atypical megakaryoblasts is a characteristic of megakaryoblastic leukemia. Cells from patients with this disorder and cell lines established from this type of leukemia showed the presence of gelsolin but the absence of scinderin expression, 2 filamentous actin-severing proteins present in normal megakaryocytes and platelets. Vector-mediated expression of scinderin in the megakaryoblastic cell line MEG-01 induced a decrease in both F-actin and gelsolin. This was accompanied by increased Rac2 expression and by activation of the PAK/MEKK.SEK/JNK/c-jun, c-fos transduction pa

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38

Qi, Kunming, Xueting Hu, Xiangru Yu, et al. "Targeting cyclin-dependent kinases 4/6 inhibits survival of megakaryoblasts in acute megakaryoblastic leukaemia." Leukemia Research 120 (September 2022): 106920. http://dx.doi.org/10.1016/j.leukres.2022.106920.

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39

San Miguel, JF, M. Gonzalez, MC Canizo, et al. "Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics." Blood 72, no. 2 (1988): 402–7. http://dx.doi.org/10.1182/blood.v72.2.402.402.

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Abstract The clinical, hematologic, and phenotypic features of 28 patients with acute leukemia with megakaryocytic involvement (AMKL) were analyzed. The prevalence of this type of leukemia in the entire series was 11.6%, with a higher incidence among patients with acute transformation of a previous myeloproliferative disorder (MPD) (24%) than among the transformed myelodysplastic syndrome (13%) patients. The incidence in the “de novo” ANLL was 8% and 16% among secondary leukemias. The presence of bone marrow fibrosis together with low WBC and normal or increased platelet counts despite a sever

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San Miguel, JF, M. Gonzalez, MC Canizo, et al. "Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics." Blood 72, no. 2 (1988): 402–7. http://dx.doi.org/10.1182/blood.v72.2.402.bloodjournal722402.

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The clinical, hematologic, and phenotypic features of 28 patients with acute leukemia with megakaryocytic involvement (AMKL) were analyzed. The prevalence of this type of leukemia in the entire series was 11.6%, with a higher incidence among patients with acute transformation of a previous myeloproliferative disorder (MPD) (24%) than among the transformed myelodysplastic syndrome (13%) patients. The incidence in the “de novo” ANLL was 8% and 16% among secondary leukemias. The presence of bone marrow fibrosis together with low WBC and normal or increased platelet counts despite a severe anemia

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Molossi, Franciéli Adriane, Luan Cleber Henker, Bianca Santana De Cecco, et al. "Pathological and immunohistochemical aspects of acute megakaryoblastic leukaemia in a cat – Short communication." Acta Veterinaria Hungarica 69, no. 2 (2021): 175–79. http://dx.doi.org/10.1556/004.2021.00025.

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AbstractAn adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia and constipation for three days. Physical examination revealed splenomegaly, cachexia, and dehydration. Humane euthanasia was conducted, followed by postmortem examination. Grossly, the cat was icteric, and presented hepatomegaly with multifocal white spots and splenomegaly. Histologically, the bone marrow was nearly completely replaced by a proliferation of megakaryocytes and megakaryoblasts, and there was a proliferation of fibrous connective tissue.

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Zipursky, A., H. Wang, EJ Brown, and J. Squire. "Interphase cytogenetic analysis of in vivo differentiation in the myelodysplasia of Down syndrome." Blood 84, no. 7 (1994): 2278–82. http://dx.doi.org/10.1182/blood.v84.7.2278.2278.

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Abstract In Down syndrome, acute megakaryoblastic leukemia (AMKL) occurs frequently during the first 4 years of life and is usually preceded by a period of myelodysplasia (MDS), often associated with chromosomal abnormalities. Archival peripheral blood and/or bone marrow films of six patients with Down syndrome and MDS whose leukemic cells contained monosomy 7 or trisomy 8 were studied to determine whether the abnormal precursors produce mature cells in vivo. Using fluorescence in situ hybridization (FISH) of interphase nuclei with chromosome-specific centromere probes for either chromosome 7

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Zipursky, A., H. Wang, EJ Brown, and J. Squire. "Interphase cytogenetic analysis of in vivo differentiation in the myelodysplasia of Down syndrome." Blood 84, no. 7 (1994): 2278–82. http://dx.doi.org/10.1182/blood.v84.7.2278.bloodjournal8472278.

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In Down syndrome, acute megakaryoblastic leukemia (AMKL) occurs frequently during the first 4 years of life and is usually preceded by a period of myelodysplasia (MDS), often associated with chromosomal abnormalities. Archival peripheral blood and/or bone marrow films of six patients with Down syndrome and MDS whose leukemic cells contained monosomy 7 or trisomy 8 were studied to determine whether the abnormal precursors produce mature cells in vivo. Using fluorescence in situ hybridization (FISH) of interphase nuclei with chromosome-specific centromere probes for either chromosome 7 or 8, we

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Boudreau, Luc H., Vanessa L. Gauvin, Jaël Richard, Marie-France N. Soucy, Mathieu P. A. Hébert, and Eric P. Allain. "Abstract 1381: Characterization of the 12-lipoxygenase expression in the megakaryoblastic cell line, Dami." Cancer Research 84, no. 6_Supplement (2024): 1381. http://dx.doi.org/10.1158/1538-7445.am2024-1381.

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Abstract Megakaryocytes are myeloid cells produced primarily in the bone marrow and are best known for releasing platelets in the blood stream. In the platelet production process, megakaryocytes transfer their bioactive content, including the 12-lipoxygenase (12-LO) enzyme, into newly formed platelets. The 12-LO has been shown to be implicated in platelet activation and is overexpressed in several chronic inflammatory conditions, including several types of cancers. The 12-LO is responsible for the conversion of the arachidonic acid into the 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), a ke

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Snarska, A., and P. Sobiech. "Evaluation of bone marrow with particular consideration of the megakaryocyte lineage and coagulation profile in the pregnant fallow deer (Dama dama)." Polish Journal of Veterinary Sciences 19, no. 2 (2016): 359–64. http://dx.doi.org/10.1515/pjvs-2016-0044.

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Abstract The aim of the study was to evaluate the megakaryocyte lineage of bone marrow and coagulation parameters in fallow deer during the last month of pregnancy. The animals were managed in the barn-feeding system. Twenty female fallow deer, aged 2-3 years, divided into 2 groups were used in the study. Group 1 comprised the females in the last month of pregnancy, and the non-pregnant females were used as the control. All the animals were clinically healthy. Coagulation parameters were measured in all the deer: thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time

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Wiseman, Daniel H., Denise K. Bonney, and Robert F. Wynn. "Hemophagocytosis by Leukemic Megakaryoblasts in Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)(p13;q13);RBM15-MKL1." Journal of Pediatric Hematology / Oncology 34, no. 7 (2012): 576–80. http://dx.doi.org/10.1097/mph.0b013e318245a027.

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Canzano, Paola, Laura Rossetti, Nicola Ferri, et al. "Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation." Thrombosis and Haemostasis 114, no. 09 (2015): 579–92. http://dx.doi.org/10.1160/th14-10-0830.

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SummaryTissue factor (TF), the main activator of the blood coagulation cascade, has been shown to be expressed by platelets. Despite the evidence that both megakaryocytes and platelets express TF mRNA, and that platelets can make de novo protein synthesis, the main mechanism thought to be responsible for the presence of TF within platelets is through the uptake of TF positive microparticles. In this study we assessed 1) whether human megakaryocytes synthesise TF and transfer it to platelets and 2) the contribution of platelet-TF to the platelet hemostatic capacity. In order to avoid the cross-

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Morgan, D. A., and I. Brodsky. "Novel peripheral blood-derived human cell lines with properties of megakaryocytes." Journal of Cell Biology 100, no. 2 (1985): 565–73. http://dx.doi.org/10.1083/jcb.100.2.565.

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For 18 mo, we derived 18 cell lines from 11 donors with various clinical profiles ranging from normal to leukemic. Suspension cultures were initiated with 1 X 10(6) mononuclear blood cells/ml of nutrient medium containing 10% human serum and 10% lectin-stimulated human lymphocyte conditioned medium. The cultures were monitored weekly by morphological analyses of Wright-Giemsa-stained cell preparations. All successful cultures showed a significant decline in viability during the first 3-4 wk with rate "lymphoid" cells observed in mitosis. Within the next 2 wk, the proliferating cells gave rise

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Ignatova, A. K., I. I. Kalinina, D. A. Venyov, et al. "CLINICAL FEATURES AND RESULTS OF THERAPY IN INFANTS AND CHILDREN AGED 1 TO 3 YEARS OLD WITH ACUTE MYELOID LEUKEMIA." Pediatria. Journal named after G.N. Speransky 102, no. 3 (2023): 63–70. http://dx.doi.org/10.24110/0031-403x-2023-102-3-63-70.

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Infants of the first year of life represent a unique group of patients with acute myeloid leukemia (AML). Materials and methods of the research: the characteristics of 492 patients with newly diagnosed AML aged 10 DoL-18 y/o who received intensive chemotherapy according to the AML-MM-2006 and AML-MRD-2018 guidelines in Apr. 2007-Apr. 2021 were analyzed. The analysis was carried out separately for infants (<1 y/o, 58/12%), young children (1-3 y/o, 99/20%) and children aged 3-18 y/o (335/68%). Results: the infant group was characterized by a higher incidence of hyperleukocytosis, extramedulla

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Ignatova, A. K., I. I. Kalinina, D. A. Venyov, et al. "CLINICAL FEATURES AND RESULTS OF THERAPY IN INFANTS AND CHILDREN AGED 1 TO 3 YEARS OLD WITH ACUTE MYELOID LEUKEMIA." Pediatria. Journal named after G.N. Speransky 102, no. 3 (2023): 8–15. http://dx.doi.org/10.24110/0031-403x-2023-102-3-8-15.

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Infants of the first year of life represent a unique group of patients with acute myeloid leukemia (AML). Materials and methods of the research: the characteristics of 492 patients with newly diagnosed AML aged 10 DoL-18 y/o who received intensive chemotherapy according to the AML-MM-2006 and AML-MRD-2018 guidelines in Apr. 2007-Apr. 2021 were analyzed. The analysis was carried out separately for infants (<1 y/o, 58/12%), young children (1-3 y/o, 99/20%) and children aged 3-18 y/o (335/68%). Results: the infant group was characterized by a higher incidence of hyperleukocytosis, extramedulla

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