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Dissertations / Theses on the topic 'Megakaryopoiesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Pan, Jiajia. "The Role of DIAPH1 in the Megakaryopoiesis." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T074/document.

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Les mégacaryocytes sont les précurseurs cellulaires hautement spécialisés qui produisent des plaquettes via des extensions cytoplasmiques appelées proplaquettes. La formation des proplaquettes exige de profonds changements dans l’organisation du cytosquelette: microtubules et actine. Les formines sont une famille de protéines hautement conservées chez les eucaryotes composées de plusieurs domaines qui régulent le remodelage et la dynamique du cytosquelette d'actine et des microtubules. La plupart des formines sont des effecteurs protéiques des Rho-GTPase. DIAPH1, un membre de la famille des fo

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2

Radhakrishnan, Aparna. "Genetic variation studies of megakaryopoiesis, platelet formation and platelet function." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708102.

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3

Johnson, Lacey Nicole St George Clinical School UNSW. "Molecular regulation of Megakaryopoiesis: the role of Fli-1 and IFI16." Awarded by:University of New South Wales. St George Clinical School, 2006. http://handle.unsw.edu.au/1959.4/26819.

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Megakaryocytes (Mks) are unique bone marrow cells, which produce platelets. Dysregulated Mk development can lead to abnormal platelet number and the production of functionally defective platelets, causing bleeding, thrombotic events, and leukaemia. Understanding the molecular mechanisms driving megakaryopoiesis may yield insights into the molecular genetics and cellular pathophysiology of a diversity of disorders. The primary aim of this thesis was to gain insight into the molecular events required for normal Mk development. As transcription factors and cytokines play a central role in driving

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4

Houwerzijl, Ewout Johan. "Studies on megakaryopoiesis in patients with myelodysplasia and idiopathic thrombocytopenic purpura." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306088665.

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5

Xiong, Y. "Regulation of T-cell adhesion and megakaryopoiesis by immune adaptor ADAP." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3011772/.

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The immune adaptor ADAP possesses versatile roles in a variety of immune cells, including T cells, dendritic cells, macrophages, and platelets, etc. The most extensivelystudied role of ADAP is that it couples TCR activation to integrin activation and T-cell adhesion. However, the regulation of this adaptor during integrin activation and T-cell adhesion remains unclear. Meantime, the functions of ADAP linked to other immune cells are largely unknown. Work in this thesis have identified Ubc9, the sole SUMO E2 conjugase, as an essential regulator of ADAP in T-cell adhesion. We show that ADAP inte

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6

Mazzi, Stefania. "Study of the role of the methyltransferase EZH2 in normal and pathological megakaryopoiesis." Thesis, Sorbonne Paris Cité, 2018. https://theses.md.univ-paris-diderot.fr/MAZZI_Stefania_2_complete_20180926.pdf.

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Le processus qui aboutit à la formation de plaquettes est appelé mégacaryopoïèse. Les mégacaryocytes (MK) sont de grandes cellules de la moelle osseuse qui par fragmentation dans la circulation sanguine produisent des plaquettes. La régulation extrinsèque ou intrinsèque de ce processus a été largement étudiée. Cependant la régulation épigénétique reste mal connue bien que de nombreuses mutations dans des gènes de régulateurs épigénétiques soient retrouvées dans les hémopathies malignes de la lignée MK. En particulier des mutations du gène de la méthyltransférase EZH2, composant catalytique du

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7

Ye, Jieyu, and 叶洁瑜. "The role of platelet-derived molecules: PDGF and serotonin in the regulation of megakaryopoiesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47244446.

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Investigations on platelet-derived growth factor (PDGF) and serotonin (5-HT), molecules stored in platelet granules, imply their potential effects in regulating megakaryopoiesis, which also intimates the existence of an autocrine and/or paracrine loop constructed by megakaryocytes/platelets and their granular constituents. In addition, numerous reports indicate that melatonin, a derivative from serotonin effectively enhances platelet counts in patients with thrombocytopenia. However, their exact roles on human megakaryocytes and the underlying mechanisms remain unknown. Present studies sh

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8

Fock, Ee-Ling Clinical School St George Hospital Faculty of Medicine UNSW. "Molecular regulation and enhancement of megakaryopoiesis and thrombopoiesis by the p45 subunit of NF-E2." Publisher:University of New South Wales. Clinical School - St George Hospital, 2008. http://handle.unsw.edu.au/1959.4/42885.

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Megakaryocytes (MKs) are a rare population of haematopoietic cells, which produce platelets. Platelet production is a complex process that is tightly regulated at the transcriptional level by lineage specific transcription factors such as p45 NF-E2. Understanding how transcriptional regulators operate is imperative to advance our knowledge of disease pathophysiology and to propose novel treatment options. Therefore, the aims of this study were to: i) study the effects of p45 NF-E2 overexpression on various stages of megakaryopoiesis; (ii) elucidate the nuclear transport mechanisms of p45 NF-E2

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9

Chen, Jianliang, and 陈健良. "The inhibitory effects of human cytomegalovirus on megakaryopoiesis : megekaryocytic cells and bone marrow derived mesenchymal stormal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193520.

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Thrombocytopenia is one of the most common hematologic presentations of active human cytomegalovirus (HCMV) infection, especially in recipients of allogeneic hematopoietic stem cell transplantations and newborns of congenital HCMV infection. However, mechanisms of HCMV-induced thrombocytopenia have not been well understood. The precursor of circulating platelets – megakaryocyte, is derived from hematopoietic stem/progenitor cell in bone marrow. We postulate that inhibition to megakaryocytic development is the major pathogenesis of HCMV-induced thrombocytopenia. Megakaryocytic cells as well as

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10

El, khoury Mira. "Rôle de la calréticuline dans les néoplasmes myéloprolifératifs." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC227.

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Les néoplasmes myéloprolifératifs (NMPs) classiques BCR-ABL négatifs regroupent la Polyglobulie de Vaquez, la Thrombocytémie Essentielle et la Myélofibrose Primaire. Ce sont des pathologies malignes clonales entraînées par la signalisation constitutive de la voie JAK2/STAT en raison de mutations somatiques acquises qui affectent trois gènes, JAK2, CALR et MPL. Il s’agit des mutations “motrices” de la maladie responsable du syndrome myéloprolifératif et du phénotype. Cependant CALR n’est pas une molécule de signalisation mais une chaperonne du réticulum endoplasmique. En utilisant des lignées d

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11

Choudry, Fizzah Aziz. "Novel insights into megakaryopoiesis, thrombopoiesis and acute coronary thrombosis : transcriptome profiling of the haematopoietic stem cell, megakaryocyte and platelet." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283252.

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The aim of this project was to investigate the transcriptome of human haematopoietic stem cells (HSCs), megakaryocytes and platelets to gain insights into steady state and accelerated thrombopoiesis that occurs in states of haemostatic demand and in thrombosis by applying these findings to the pathological setting of acute coronary thrombosis. To investigate transcriptional heterogeneity within the human HSC population, single cell RNA sequencing was performed in human bone marrow HSCs. Transcriptionally distinct subpopulations were identified including two megakaryocyte biased subsets with po

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12

Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found to localise to the cytoplasm

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13

Hallal, Samantha. "Characterisation of the zinc fingers of Erythroid Kruppel-Like Factor." University of Sydney, 2008. http://hdl.handle.net/2123/4030.

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Doctor of Philosophy (PhD)<br>Gene expression is known to be regulated at the level of transcription. Recently, however, there has been a growing realisation of the importance of gene regulation at the post-transcriptional level, namely at the level of pre-mRNA processing (5’ capping, splicing and polyadenylation), nuclear export, mRNA localisation and translation. Erythroid krüppel-like factor (Eklf) is the founding member of the Krüppel-like factor (Klf) family of transcription factors and plays an important role in erythropoiesis. In addition to its nuclear presence, Eklf was recently found

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14

Gorelashvili, Maximilian Georg [Verfasser], David [Gutachter] Stegner, Katrin [Gutachter] Heinze, Guido [Gutachter] Stoll, and Bernhard [Gutachter] Nieswandt. "Investigation of megakaryopoiesis and the acute phase of ischemic stroke by advanced fluorescence microscopy / Maximilian Georg Gorelashvili ; Gutachter: David Stegner, Katrin Heinze, Guido Stoll, Bernhard Nieswandt." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1201278295/34.

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15

Rivière, Étienne. "Implication de la protéine Bcl-xL dans la mégacaryopoïèse humaine normale et dans le purpura thrombopénique immunologique chronique." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0148/document.

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La protéine Bcl-xL fait partie de la famille des protéines anti-apoptotiques Bcl-2. Il a été montré que cette protéine avait un rôle majeur dans la formation des plaquettes chez la souris (mégacaryopoïèse). Une dérégulation de cette protéine pourrait aboutir à une altération de la mégacaryopoïèse et donner des pathologies humaines comme des thrombopénies chroniques. Une des causes de thrombopénies chroniques est le purpura thrombopénique immunologique (ou PTI), qui associe deux mécanismes physiopathologiques : une destruction auto-immune des plaquettes et une insuffisance de leur production pa

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16

Bouzid, Hind. "Etudes des mécanismes conduisant à l'état pré-leucémique des patients FPD/AML." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC299.

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La thrombopénie familiale avec prédisposition à la leucémie aiguë myéloïde (FPD/AML) est une pathologie rare caractérisée par une thrombocytopénie. La FPD/AML est causée par des mutations germinales dans le gène codant le facteur de transcription RUNX1. Ces mutations sont de type dominant négatif (DN), associées à un risque plus élevé de développer une leucémie, ou de type haploinsuffisance (HI) induisant une thrombocytopénie seule. Nous avons démontré une diminution presque complète de l’expression du répresseur transcriptionnel ZBTB1 dans les progéniteurs hématopoïétiques des patients porteu

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17

Jost, Camille. "Rôle du microenvironnement cellulaire de la mégacaryopoïèse." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ015/document.

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Les plaquettes sanguines ont comme rôle principal d’arrêter les saignements. Elles sont produites dans la moelle osseuse par des mégacaryocytes (MK) qui proviennent de la différenciation des cellules souches hématopoïétiques (CSH). L’objectif de ma thèse a été d’identifier les éléments cellulaires du microenvironnement contrôlant la mégacaryopoïèse. Mon travail a permis d’identifier une population particulière de progéniteurs hépatiques du foie foetal capable de promouvoir in vitro les étapes précoces de la mégacaryopoïèse à partir de CSH humaines et murines (Brouard et al., 2017). Le rôle des

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18

Boullu, Lois. "Étude d’équations à retard appliquées à la régulation de la production de plaquettes sanguines." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1239/document.

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L’objectif de cette thèse est d’étudier, à l’aide de modèles mathématiques, le mécanisme de régulation qui permet au corps de maintenir une quantité optimale de plaquettes sanguines. Le premier chapitre présente le contexte biologique et mathématique. Dans un second chapitre, un modèle pour la mégacaryopoïèse est introduit qui suppose une régulation ponctuelle par le nombre de plaquettes du taux de différentiation des cellules souches vers la lignée mégacaryocytaire et du nombre de plaquettes produites par mégacaryocyte. Nous montrons que la dynamique de ce modèle est régie par une équation di

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19

Fu, Wenwen [Verfasser], and Steffen [Akademischer Betreuer] Massberg. "Megakaryopoietic islands in the bone marrow balance platelet production and maintain megakaryocyte homeostasis / Wenwen Fu ; Betreuer: Steffen Massberg." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1201274303/34.

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20

Lin, Guan-Ling, and 林冠伶. "Role of dengue virus envelope protein domain III in megakaryopoiesis suppression." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/b2xz5n.

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博士<br>慈濟大學<br>醫學科學研究所<br>105<br>Dengue virus (DENV) causes 50-100 million infections annually worldwide. Thrombocytopenia is the common feature of dengue viruses-induced mild dengue fever, more severe dengue hemorrhage fever, and dengue shock syndrome. Megakaryopoiesis is the differentiation and maturation processes of megakaryocytes which are the precursors of platelets. Previous studies have demonstrated that DENV can induce thrombocytopenia by megakaryopoiesis suppression; however, the mechanism for megakaryopoiesis suppression, such as whether viral replication is required or what molecule

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21

Po-Kong, Chen, and 諶伯綱. "Characterization of the Pathogenic Effects of Anthrax Lethal Toxin on Megakaryopoiesis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/24546649201779662832.

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博士<br>慈濟大學<br>醫學科學研究所<br>101<br>Megakaryocytes are the precursor cells of platelets and critical for maintaining coagulant functions. Thrombopoietin (TPO), the ligand for c-mpl, stimulates proliferation of committed megakaryocytic progenitors and induces maturation of megakaryocytes. In the first part of this study, we established the in vitro megakaryocyte differentiation system from embryonic stem cells co-cultured with OP9 stromal cells. OP9 stromal cells, derived from mouse bone marrow, are useful feeder cells for hematopoiesis in ES cell co-culture systems. However, OP9 is a primary cell

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22

Gorelashvili, Maximilian Georg. "Investigation of megakaryopoiesis and the acute phase of ischemic stroke by advanced fluorescence microscopy." Doctoral thesis, 2019. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-186002.

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In mammals, anucleate platelets circulate in the blood flow and are primarily responsible for maintaining functional hemostasis. Platelets are generated in the bone marrow (BM) by megakaryocytes (MKs), which mainly reside directly next to the BM sinusoids to release proplatelets into the blood. MKs originate from hematopoietic stem cells and are thought to migrate from the endosteal to the vascular niche during their maturation, a process, which is, despite being intensively investigated, still not fully understood. Long-term intravital two photon microscopy (2PM) of MKs and vasculature in mur

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23

Boullu, Loïs. "Étude d’équations à retard appliquées à la régulation de la production de plaquettes sanguines." Thèse, 2018. http://hdl.handle.net/1866/21745.

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