Relevant bibliographies by topics / Megalin

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Academic literature on the topic 'Megalin'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 March 2023

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Journal articles on the topic "Megalin"

1

Lou, Xiaojing, Tammie McQuistan, Robert A. Orlando, and Marilyn Gist Farquhar. "GAIP, GIPC and Gαi3 are Concentrated in Endocytic Compartments of Proximal Tubule Cells: Putative Role in Regulating Megalin’s Function." Journal of the American Society of Nephrology 13, no. 4 (April 2002): 918–27. http://dx.doi.org/10.1681/asn.v134918.

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ABSTRACT. Megalin is the most abundant endocytic receptor in the proximal tubule epithelium (PTE), where it is concentrated in clathrin-coated pits (CCPs) and vesicles in the brush border region. The heterotrimeric G protein alpha subunit, Gαi3, has also been localized to the brush border region of PTE. By immunofluorescence GIPC and GAIP, components of G protein-mediated signaling pathways, are also concentrated in the brush border region of PTE and are present in megalin-expressing cell lines. By cell fractionation, these signaling molecules cosediment with megalin in brush border and microvillar fractions. GAIP is found by immunoelectron microscopy in CCPs, and GIPC is found in CCPs and apical tubules of endocytic compartments in the renal brush border. In precipitation assays, GST-GIPC specifically binds megalin. The concentration of Gαi3, GIPC, and GAIP with megalin in endocytic compartments of the proximal tubule, where extensive endocytosis occurs, and the interaction between GIPC and the cytoplasmic tail of megalin suggest a model whereby G protein-mediated signaling may regulate megalin’s endocytic function and/or trafficking.
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RADER, KATHERINE, ROBERT A. ORLANDO, XIAOJING LOU, and MARILYN GIST FARQUHAR. "Characterization of ANKRA, a Novel Ankyrin Repeat Protein that Interacts with the Cytoplasmic Domain of Megalin." Journal of the American Society of Nephrology 11, no. 12 (December 2000): 2167–78. http://dx.doi.org/10.1681/asn.v11122167.

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Abstract. Ankyrin-repeat family A protein (ANKRA) is a novel protein that interacts directly and specifically with the cytoplasmic tail of megalin in the yeast two-hybrid system and glutathione-S-transferase pull-down assays. ANKRA has three ankyrin repeats and shows 61% overall homology to regulatory factor X, ankyrin repeat-containing protein. Mapping studies show that the three ankyrin repeats and C-terminus of ANKRA are required for binding to a unique juxtamembrane, 19-amino acid sequence on the megalin tail. Point mutational analysis reveals that a proline-rich motif (PXXPXXP) within this region is the site of ANKRA binding. ANKRA interacts with megalin but not with low-density lipoprotein receptor related protein, in keeping with the fact that the sequence of the megalin tail is unique. By cell fractionation, ANKRA is found both in the cytosol and associated with membranes enriched in megalin in L2 cells and proximal tubule cells. By immunofluorescence, ANKRA is concentrated near megalin along the plasma membrane of L2 cells and in the kidney cortex is expressed in glomerular and proximal tubule epithelia which also express megalin. These observations suggest that ANKRA may play a unique role in megalin's function as a clearance receptor in the kidney and L2 cells. In addition, ANKRA may have other partners because northern blot analysis reveals that ANKRA is more broadly expressed than megalin, and by immunofluorescence ANKRA is also expressed in connecting tubule cells and principal cells of collecting ducts.
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Takeda, Tetsuro, Hajime Yamazaki, and Marilyn G. Farquhar. "Identification of an apical sorting determinant in the cytoplasmic tail of megalin." American Journal of Physiology-Cell Physiology 284, no. 5 (May 1, 2003): C1105—C1113. http://dx.doi.org/10.1152/ajpcell.00514.2002.

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Megalin is the main endocytic receptor of the proximal tubule and is responsible for reabsorption of many filtered proteins. In contrast to other members of the low-density lipoprotein (LDL) receptor gene family, it is expressed on the apical plasma membrane (PM) of polarized epithelial cells. To identify megalin's apical sorting signal, we generated deletion mutants and chimeric minireceptors composed of complementary regions of megalin and LDL receptor-related protein (LRP) and assessed the distribution of the mutants in Madin-Darby canine kidney (MDCK) cells by immunofluorescence and cell surface biotinylation. Megalin and LRP minireceptors are correctly targeted to the apical and basolateral PM, respectively, of MDCK cells. We found that the information that directs apical sorting is present in the cytoplasmic tail (CT) of megalin, which contains three NPXY motifs, YXXØ, SH3, and dileucine motifs, and a PDZ-binding motif at its COOH terminus. Deletion analysis established that amino acids 107–136 of the megalin-CT containing the second NPXY-like motif are critical for apical sorting and targeting, whereas the regions containing the first and third NPXY motifs are required for efficient endocytosis. We conclude that the megalin-CT contains a novel apical sorting determinant and that cytoplasmic sorting machinery exists in MDCK cells for some apical transmembrane proteins.
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Hosojima, Michihiro, Hiroyoshi Sato, Keiko Yamamoto, Ryohei Kaseda, Taeko Soma, Asako Kobayashi, Akiyo Suzuki, et al. "Regulation of Megalin Expression in Cultured Proximal Tubule Cells by Angiotensin II Type 1A Receptor- and Insulin-Mediated Signaling Cross Talk." Endocrinology 150, no. 2 (February 1, 2009): 871–78. http://dx.doi.org/10.1210/en.2008-0886.

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Impairment of proximal tubular endocytosis of glomerular-filtered proteins including albumin results in the development of proteinuria/albuminuria in patients with chronic kidney disease. However, the mechanisms regulating the proximal tubular function are largely unknown. This study aimed to investigate the role of angiotensin II type 1A receptor (AT1AR)- and insulin-mediated signaling pathways in regulating the expression of megalin, a multiligand endocytic receptor in proximal tubule cells (PTCs). Opossum kidney PTC-derived OK cells that stably express rat AT1AR but are deficient in endogenous angiotensin II receptors (AT1AR-OK cells) were used for this study. Treatment of the cells with angiotensin II suppressed mRNA and protein expression of megalin at 3- and 24-h incubation time points, respectively. Cellular uptake and degradation of albumin and receptor-associated protein, megalin’s endocytic ligands were suppressed 24 h after angiotensin II treatment. The AT1AR-mediated decrease in megalin expression was partially prevented by ERK inhibitors. Insulin competed with the AT1AR-mediated ERK activation and decrease in megalin expression. Inhibitors of phosphatidylinositol 3-kinase (PI3K), a major component of insulin signaling, also suppressed megalin expression, and activation of the insulin receptor substrate (IRS)/PI3K system was prevented by angiotensin II. Collectively the AT1AR-mediated ERK signaling is involved in suppressing megalin expression in the OK cell line, and insulin competes with this pathway. Conversely, the insulin-IRS/PI3K signaling, with which angiotensin II competes, tends to stimulate megalin expression. In conclusion, there is AT1AR- and insulin-mediated competitive signaling cross talk to regulate megalin expression in cultured PTCs. Angiotensin II type 1A receptor- and insulin-mediated competitive signaling cross-talk regulates the expression of megalin, a multi-ligand endocytic receptor, in cultured proximal tubule cells.
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Gravotta, Diego, Andres Perez Bay, Caspar T. H. Jonker, Patrick J. Zager, Ignacio Benedicto, Ryan Schreiner, Paulo S. Caceres, and Enrique Rodriguez-Boulan. "Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes." Molecular Biology of the Cell 30, no. 14 (July 2019): 1716–28. http://dx.doi.org/10.1091/mbc.e18-12-0811.

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Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein receptor family that displays a large luminal domain with multiligand binding properties. Megalin localizes to the apical surface of multiple epithelia, where it participates in endocytosis of a variety of ligands performing roles important for development or homeostasis. We recently described the apical recycling pathway of megalin in Madin–Darby canine kidney (MDCK) cells and found that it is a long-lived, fast recycling receptor with a recycling turnover of 15 min and a half-life of 4.8 h. Previous work implicated clathrin and clathrin adaptors in the polarized trafficking of fast recycling basolateral receptors. Hence, here we study the role of clathrin and clathrin adaptors in megalin’s apical localization and trafficking. Targeted silencing of clathrin or the γ1 subunit of clathrin adaptor AP-1 by RNA interference in MDCK cells disrupted apical localization of megalin, causing its redistribution to the basolateral membrane. In contrast, silencing of the γ2 subunit of AP-1 had no effect on megalin polarity. Trafficking assays we developed using FM4-HA-miniMegalin-GFP, a reversible conditional endoplasmic reticulum–retained chimera, revealed that clathrin and AP-1 silencing disrupted apical sorting of megalin in both biosynthetic and recycling routes. Our experiments demonstrate that clathrin and AP-1 control the sorting of an apical transmembrane protein.
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Sun, Yuan, Alexandre Goes Martini, Manoe J. Janssen, Ingrid M. Garrelds, Rosalinde Masereeuw, Xifeng Lu, and A. H. Jan Danser. "Megalin." Hypertension 75, no. 5 (May 2020): 1242–50. http://dx.doi.org/10.1161/hypertensionaha.120.14845.

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Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of megalin increases urinary renin and allowed the detection of prorenin, which normally is absent in urine. Here, we investigated (pro)renin uptake by megalin, using both conditionally immortalized proximal tubule epithelial cells and Brown Norway Rat yolk sac cells (BN16). To distinguish binding and internalization, cells were incubated with recombinant human (pro)renin at 4°C and 37°C, respectively. (Pro)renin levels were assessed by immunoradiometric assay. At 4°C, BN16 cells bound 3× more prorenin than renin, suggestive for a higher affinity of prorenin. Similarly, at 37°C, prorenin accumulated at 3- to 4-fold higher levels than renin in BN16 cells. Consequently, depletion of medium prorenin (but not renin) content occurred after 24 hours. No such differences were observed in conditionally immortalized proximal tubule epithelial cells, and M6P (mannose-6-phosphate) greatly reduced conditionally immortalized proximal tubule epithelial cells (pro)renin uptake, suggesting that these cells accumulate (pro)renin largely via M6P receptors. M6P did not affect (pro)renin uptake in BN16 cells. Yet, inhibiting megalin expression with siRNA greatly reduced (pro)renin binding and internalization by BN16 cells. Furthermore, treating BN16 cells with albumin, an endogenous ligand of megalin, also decreased binding and internalization of (pro)renin, while deleting the (pro)renin receptor affected the latter only. Exposing prorenin’s prosegment with the renin inhibitor aliskiren dramatically increased prorenin binding, while after prosegment cleavage with trypsin prorenin binding was identical to that of renin. In conclusion, megalin might function as an endocytic receptor for (pro)renin and displays a preference for prorenin. Megalin-mediated endocytosis requires the (pro)renin receptor.
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Sun, Y., I. M. Garrelds, X. Lu, and A. Danser. "MEGALIN." Journal of Hypertension 37 (July 2019): e134. http://dx.doi.org/10.1097/01.hjh.0000571732.76261.b9.

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Klassen, R. Bryan S., Patricia L. Allen, Vecihi Batuman, Kimberly Crenshaw, and Timothy G. Hammond. "Light chains are a ligand for megalin." Journal of Applied Physiology 98, no. 1 (January 2005): 257–63. http://dx.doi.org/10.1152/japplphysiol.01090.2003.

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Cubilin and megalin are giant glycoprotein receptors abundant on the luminal surface of proximal tubular cells of the kidney. We showed previously that light chains are a ligand for cubilin. As cubilin and megalin share a number of common ligands, we further investigated the ligand specificity of these receptors. Three lines of evidence suggest that light chains can also bind megalin: 1) anti-megalin antiserum largely displaces brush-border light chain binding and megalin-expressing BN-16 cell uptake more than anti-cubilin antiserum, 2) direct binding studies on isolated proteins using surface plasmon resonance techniques confirm that megalin binds light chains, and 3) light chains compete with known megalin ligands for brush-border membrane binding and BN-16 cell uptake. The megalin-light chain interaction is divalent ion dependent and similar for both κ- and λ-light chains. A fit of the data on light chain binding to megalin over a concentration range 0.078–2.5 mg/ml leads to an estimated dissociation constant of 6 × 10−5 M, corresponding approximately to one light chain-binding site per megalin and in the same range for dissociation constants for cubilin binding. These data suggest that light chains bind the tandem megalin-cubilin complex. Megalin is the major mediator of light chain entry into megalin-expressing membrane such as the apical surface of proximal tubular epithelial cells.
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Wen, Lu, Pia K. Andersen, Dina M. U. Husum, Rikke Nørregaard, Zhanzheng Zhao, Zhangsuo Liu, and Henrik Birn. "MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction." American Journal of Physiology-Renal Physiology 313, no. 2 (August 1, 2017): F210—F217. http://dx.doi.org/10.1152/ajprenal.00585.2016.

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Megalin is a multiligand, endocytic receptor that is important for the normal, proximal tubule reabsorption of filtered proteins, hormones, enzymes, essential nutrients, and nephrotoxins. Megalin dysfunction has been associated with acute, as well as chronic kidney diseases. Tubular proteinuria has been observed following unilateral ureteral obstruction (UUO), suggesting megalin dysfunction; however, the pathophysiological mechanism has not been determined. To identify potential regulators of megalin expression, we examined renal microRNAs (miRNAs) expression and observed an upregulation of microRNA-148b (miR-148b) in obstructed mouse kidneys 7 days after UUO, which was associated with a significant reduction in proximal tubule megalin expression and accumulation of megalin ligands. By in silico miRNA target prediction analysis, we identified megalin messenger RNA (mRNA) as a potential target of miR-148b and confirmed using a dual-luciferase reporter assay that miR-148b targeted the 3′-untranslated region of the megalin gene. Transfection of LLC-PK1 cells with miR-148b mimic reduced endogenous megalin mRNA and protein levels in a concentration-dependent manner, while transfection with miR-148b inhibitor resulted in an increase. Our findings suggest that miR-148b directly downregulates megalin expression and that miR-148b negatively regulates megalin expression in UUO-induced kidney injury. Furthermore, the identification of a miRNA regulating megalin expression may allow for targeted interventions to modulate megalin function and proximal tubule uptake of proteins, as well as other ligands.
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Nagai, Junya, Hiroaki Tanaka, Naoki Nakanishi, Teruo Murakami, and Mikihisa Takano. "Role of megalin in renal handling of aminoglycosides." American Journal of Physiology-Renal Physiology 281, no. 2 (August 1, 2001): F337—F344. http://dx.doi.org/10.1152/ajprenal.2001.281.2.f337.

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The role of megalin in tissue distribution of aminoglycosides was examined in normal rats and maleate-treated rats that shed megalin from the renal brush-border membrane. In normal rats, amikacin administered intravenously accumulated most abundantly in the renal cortex, followed by the renal medulla. No amikacin was detected in other tissues. Tissue distributions of amikacin were well correlated with megalin levels in each tissue. Bolus administration of gentamicin increased urinary excretion of megalin ligands (vitamin D binding protein and calcium), suggesting the competition between gentamicin and these megalin ligands in renal tubules. Ligand blotting showed that binding of45Ca2+ to megalin was inhibited by aminoglycosides. Both megalin levels and amikacin accumulation in renal cortex were decreased by maleate injection. Then, amikacin accumulation recovered proportionate to megalin levels. These findings suggest that megalin is involved in the renal cortical accumulation of aminoglycosides in vivo. In addition, the interaction between aminoglycosides and calcium in the kidney may be due to the competition among these compounds to bind to megalin.
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Dissertations / Theses on the topic "Megalin"

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Inoue, Bruna Hitomi. "Bases moleculares da microalbuminúria associada à hipertensão arterial essencial: papel da reabsorção tubular de albumina." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-13122012-161119/.

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Evidências epidemiológicas indicam que a presença de microalbuminúria prediz maior freqüência de eventos cardiovasculares e mortalidade em hipertensos essenciais. A microalbuminúria pode ser decorrente do aumento da permeabilidade glomerular e/ou da diminuição da reabsorção desta macromolécula no túbulo proximal. Todavia não é sabido se os mecanismos que regulam a reabsorção de albumina em túbulo proximal renal encontram-se alterados na hipertensão essencial. Este trabalho teve como objetivo investigar as bases moleculares da microalbuminúria associada à hipertensão arterial essencial, focando na reabsorção tubular de albumina. Para tanto, avaliamos a evolução temporal da excreção urinária de albumina em ratos espontaneamente hipertensos (SHR) com 6 semanas de idade (pressão arterial sistólica, PAS, = 105 ± 4 mmHg), 14 semanas de idade (PAS = 180 ± 2 mmHg) e 21 semanas de idade (PAS = 202 ± 2 mmHg). Ratos normotensos Wistar da mesma idade serviram de controle. Observou-se que a excreção urinária diária de albumina aumentou progressivamente com o aumento da pressão arterial em SHR (10,5 ± 1,9; 92 ± 7,0 e 154 ± 27 g/dia, em SHR com PAS média igual a 105, 180 e 202 mmHg respectivamente). Este aumento progressivo não foi observado em ratos normotensos com idade correspondente, indicando que este fenômeno é decorrente do aumento da pressão arterial e não pode ser atribuído ao aumento da idade dos animais durante o período estudado. A análise das proteínas urinárias por eletroforese em gel de poliacrilamida (SDS-PAGE) mostrou que SHR excretam proteínas do tamanho da albumina ou menores (< 70kDa), padrão típico de proteinúria tubular. Adicionalmente, verificou-se que os níveis de expressão dos receptores endocíticos megalina e cubilina, bem como do canal para cloreto ClC-5 diminuem progressivamente no córtex renal de SHR com o aumento da pressão arterial. Observou-se também uma diminuição significativa na expressão de uma outra macromolécula importante no processo de endocitose mediada por receptor em túbulo proximal renal, a v-H+-ATPase. Entretanto, a diminuição da expressão protéica da subunidade B2 desta ATPase foi estatisticamente significante apenas em SHR com 21 semanas comparado aos com 6 semanas de idade. Não foram encontradas alterações no padrão de expressão de componentes estruturais da barreira glomerular como a nefrina e podocina. Em suma, o nosso estudo demonstra que o aumento da excreção urinária de proteínas, especialmente de albumina, está associado com uma menor expressão de componentes essenciais do aparelho endocítico do túbulo proximal renal. É tentador especular que a disfunção da via endocítica no túbulo proximal renal possa ser o principal mecanismo subjacente ao desenvolvimento de microalbuminúria na hipertensão
Epidemiological evidences indicate that the presence of microalbuminuria predicts a higher frequency of cardiovascular events and mortality in essential hypertensive patients. Microalbuminuria may arise from increased glomerular permeability and/or reduced proximal tubular reabsorption of albumin. However, it remains to be determined whether the mechanisms that regulate the renal proximal tubular reabsorption of albumin are altered in essential hypertension. The purpose of this work was to investigate the molecular basis of microalbuminuria in essential hypertension, focusing on the renal tubular reabsorption of albumin. To this end, we evaluated the temporal evolution of urinary albumin excretion in spontaneously hypertensive rats (SHR) at 6 weeks of age (systolic arterial pressure, SAP, = 105 ± 4 mmHg), 14 weeks of age (SAP = 180 ± 2 mmHg) and 21 weeks of age (SAP = 202 ± 2 mmHg). Age-matched normotensive Wistar rats were used as controls. It was observed that the daily urinary excretion of albumin progressively increased with blood pressure in SHR from 6 to 21 weeks of age (10.5 ± 1.9, 92 ± 7.0 and 154 ± 27 g in SHR with 105, 180 and 202 mmHg of average SAP, respectively). This progressive increase in microalbuminuria has not been observed in age-matched normotensive Wistar rats, indicating that this phenomenon cannot be attributed to age progression over the studied period. SDS-PAGE analysis of urinary proteins showed that microalbuminuric SHR virtually excreted proteins of the size of albumin or smaller (< 70kDa), typical of tubular proteinuria. Additionally, it was verified that the protein expression levels of the endocytic receptors megalin and cubilin as well as of the chloride channel ClC-5 progressively decreased in the renal cortex of SHR from 6 to 21 weeks of age. Moreover, it was observed reduction of expression of another macromolecule that plays an important role in the process of receptor mediated endocytosis in the renal proximal tubule, the v-H+- ATPase, was reduced. However, reduced cortical expression of the B2 subunit of the v- H+-ATPase, was only statistically significant in 21-wk-old vs. 6-wk-old SHR. Expression levels of structural components of the glomerular barrier such as nephrin and podocin were unchanged. To sum up, our study demonstrates that the increase in urinary protein excretion, especially of albumin, is associated with lower expression of key components of the apical endocytic apparatus in the renal proximal tubule. It is tempting to speculate that dysfunction of the apical endocytic pathway in the renal proximal tubule may be the major mechanism underlying development of microalbuminuria in essential hypertension
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2

Larsson, Mårten. "Megalin, an Endocytotic Receptor with Signalling Potential." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6585.

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Megalin is an endocytotic receptor belonging to the low-density lipoprotein family. It has often been viewed only as merely a scavenger receptor of absorptive and secretory epithelia. Recent work has revealed that the megalin intracellular domain contains several motifs potentially binding proteins involved in signal transduction.

To find potential intracellular proteins binding to megalin, a yeast two-hybrid screening was initiated with the intracellular tail of megalin as the bait. A partial clone encoding the scaffolding protein postsynaptic protein 95 (PSD-95) was found to bind to megalin with its second PDZ-domain. Co-localization experiments in HEK-293 cells and kidney, placenta and parathyroid tissue confirmed this interaction. The PSD-95 related proteins PSD-93 and SAP102 were also confirmed to bind megalin with their PDZ2-domains, but the corresponding domain from SAP97 did not bind. Mutation analysis revealed that an amino acid residue change Ala to Thr was the cause of this.

Megalin has within the central nervous system (CNS) been shown to be expressed only in the ependymal cells and choroid plexus. Nothing has been known about megalin expression in the spinal cord. To study spatio-temporal expression of megalin in the spinal cord, extensive staining of prenatal and postnatal mouse spinal cord was undertaken. Megalin expression was found in the dorsal part of the embryonic spinal cord. Most of these cells also expressed vimentin, suggesting that megalin has a role in the normal development of astrocytes. In the postnatal mouse, megalin seems to be expressed in oligodendrocytes only in the spinal cord white matter, and co-incident with myelination. This suggests that megalin is involved in the formation and maintenance of myelin along long spinal pathways. Megalin staining was clearly seen in the nucleus of these cells, indicating that megalin works in a notch-like signalling pathway.

Uptake of retinol to the retina pigment epithelium (RPE) has long been thought to be a diffusion process. Staining for megalin in RPE revealed strong expression, and uptake experiments with 3H-retinol bound to retinol-binding protein and blocking with the LDL-receptor family specific antagonist receptor-associated protein (RAP) showed that megalin is a receptor for uptake of retinol to the RPE.

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Wicher, Grzegorz. "Clusterin and Megalin in The Spinal Cord." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7365.

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Borba, Susan Caroline Pinto. "Pesquisa de anticorpos anti-megalina em pacientes transplantados renais." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-13092010-161121/.

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Introdução: O papel do sistema HLA na evolução do transplante é indiscutível. Dados da literatura internacional e do nosso laboratório têm mostrado que este não é o único sistema envolvido nos processos de RMA (rejeição mediada por anticorpo) Esse fato é comprovado a partir da constatação de que transplantes realizados entre irmãos com total identidade HLA também são alvos da RMA. Entretanto, os alvos antigênicos desses anticorpos permanecem desconhecidos, dificultando assim o diagnostico e tratamento da RMA não-HLA. No transplante renal a presença desses anticorpos têm sido associada com anticorpos anti células endoteliais, células epiteliais tubulares, podocitos, células mesangiais e monócitos. Nosso objetivo neste estudo foi avaliar a presença e a relevância clínica de anticorpos contra a megalina, membro da família de receptores de LDL, expressa na membrana apical dos túbulos proximais, com importante papel na reabsorção de proteínas no rim. Métodos: Soros pré-transplante de 105 pacientes submetidos a transplante renal, realizado no Serviço de Transplante Renal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (UTR-HC-FMUSP) foram testados por ELISA contra 2 peptídeos da megalina estudados e sintetizados em nosso laboratório. (convencionalmente chamados 18 e 19) Resultado: Não foi detectada a presença de anticorpos do isotipo IgG nas amostras prétransplante dos pacientes estudados. Entretanto, foi detectada a presença de anticorpos do isotipo IgM anti-peptídeo 18 em 33 (31,4%) amostras de soro e anti-peptídeo 19 em 23 (21,9%). Para avaliar a significância clinica desses anticorpos dividimos os pacientes em 2 grupos: pacientes com pelo menos 1 episodio de rejeição aguda (Grupo I) e pacientes sem rejeição (Grupo II) e observamos a distribuição dos pacientes positivos nos 2 grupos. O numero de pacientes com anticorpos anti-peptídeo 18 foi igualmente distribuída nos dois grupos. (12/42, 28,5% no Grupo I e 21/63, 33,3% no Grupo II p=ns). A maioria dos pacientes com anticorpos anti-peptídeo 19 pertenciam ao grupo I (17/42, 40,5% ; 6/63, 9,5% p=0,0003). Esta analise demonstrou uma boa correlação entre presença de anticorpos anti-peptídeo 19 no soro pré-transplante e rejeição. Conclusão: Nossos dados sugerem que anticorpos IgM anti-megalina no pré-transplante podem ser um fator de risco na rejeição do aloenxerto renal. É importante salientar que a nosso conhecimento este é o primeiro estudo envolvendo megalina e rejeição no transplante clínico.
Background. Preformed donor-specific human leukocyte antigen (HLA)- antibodies are accountable for the majority of antibody-mediated rejections (AMR). However, recipients of HLA identical kidneys can develop AMR implicating putative pathogenic antibodies that are directed against non-HLA antigens. Unknown immune targets and consecutive lack of detection methods make non-HLA AMR particularly difficult to diagnose and treat. In renal transplant rejection, the presence of antibodies to non-HLA has been associated with antibodies against endothelial cells, tubular epithelial cells, podocytes, mesangial cells and monocytes. The aim of this study was to evaluate the presence and clinical relevance of preformed antibodies against megalin, a member of the LDL receptor family, expressed on the apical membrane of proximal tubules. Megalin performs a central role in renal protein reabsorption. Methods. Pré-transplant sera of 105 recipients of kidney allograft transplanted at Serviço de Transplante Renal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (STRHCFMUSP) were tested by enzyme-linked immunosorbent assay (ELISA) against 2 megalin-peptides (conventionally named 18 and 19) studied and synthetized in our laboratory. Results. Antibodies were not detected in pretranplant sera when tested for IgG isotype. However, in 33 (31,4%) sera we detected the presence of IgM antibodies to megalin-peptide18 and in 23 (21,9%) to megalin-peptide 19. To evaluate the clinical significance of these antibodies we divided the patients in 2 groups: Group I - 42 patients with at least one rejection episode during the first post-transplant year and Group II - 63 patients without any rejection episode and observed the distribution of positive patients in each of the 2 groups. Patients with megalin-peptide18 antibodies had the same distribution in both groups. (12/42, 28, 5% Group I and 21/63, 33,3% no Group II p=ns). However, patients with megalinpeptide19 antibodies were more frequent in group I. (17/42, 40,5% group I and 6/63, 9,5% group II p=0,0003). This analysis demonstrated a good correlation between preformed anti-megalin-peptide19 antibodies and allograft rejection Conclusion. Our data suggest that presence of IgM megalin antibodies before transplantation might be a risk factor for kidney allograft rejection. To our knowledge, this is the first study involving megalin and rejection in clinical transplantation.
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Baines, Richard John. "Megalin cytoplasmic tail phosphorylation and function in kidney proximal tubular cells." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9513.

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Kastner, Christian [Verfasser]. "Tubuläre Volumenregulation bei Glomerulonephritis in der Megalin-teildefizienten Maus / Christian Kastner." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026695155/34.

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Burmeister, Regina. "Untersuchungen zur Rolle des Endozytoserezeptors Megalin in der zellulären Aufnahme von Steroidcarrierproteinen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967999014.

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Akour, Amal. "The role of megalin in the transport of aminoglycosides across human placenta." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/448.

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Background: Intra-amniotic infections (IAIs) are common complications of labor and delivery. If inadequately treated, these infections can lead to significant morbidity and mortality in the mother and the fetus. Intrapartum aminoglycoside (AG) administration is recommended for the management of IAIs. AGs are known to cross the placenta and achieve bactericidal concentrations in fetal serum. However, the highest and most persistent fetal levels are achieved in renal tissue. So, the fetus may be vulnerable to the nephrotoxic effects of AGs. Megalin, a 600 kDaendocytic receptor, is responsible for the uptake of AGs into renal proximal tubular epithelial cells. This receptor is also expressed in human term placenta and it is reasonable to speculate that it is similarly involved in the placental transport of AGs. However, the mechanisms responsible for placental AG uptake and transport have not yet been characterized. Objective: To evaluate the role of megalin in the transport of AGs across human placenta. Specific aims: (1) To assess and compare megalin expression in term and preterm placental villous tissue, and (2) assess the functional activity of megalin in in vitro placental models. Methods: (1) Following IRB approval, placental tissue samples were collected from pregnant women undergoing term or preterm deliveries. Placental villous tissueswere used to quantify megalin expression by western blotting and q-PCR (2) The human choriocarcinoma cell line (BeWo cells) were grown on Transwell plates, and then megalin expression and function were assessed. Results: Megalin protein and mRNA expression were confirmed in samples of human placental villous tissues. Megalin mRNA expression declined steeply with gestational age till week 31 of gestation then it plateaued thereafter. Also, the expression in the early preterm (n=2) was six fold higher than that of both late preterm (n=3) and term placenta (n=10) (p<0.05). The uptake of 3H-gentamicin by the BeWo cells was time-dependent, saturable (Vmax=42.9 ± 4.9 nmol/mg protein/min; Km=2.93±0.68mM) and partially inhibited by megalin inhibitors. Conclusion: Megalin is expressed in human placental villous tissues as well as the BeWo cells. When grown on Transwell® plates, the BeWo cells appear to be the most appropriate model to study the in vitro transport of AGs across the apical membrane. Time, temperature and concentration dependence of gentamicin uptake in the BeWo cells indicate protein-mediated transport. The inhibition data are consistent with megalin-mediated endocytosis of AGs.
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Burmeister, Regina. "Untersuchungen zur Rolle des Endozytoserezeptors Megalin in der zellulären Aufnahme von Steroidcarrierproteinen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2003. http://dx.doi.org/10.18452/14867.

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Der Endozytoserezeptor Megalin gehört zu einer Gruppe von strukturell und funktionell verwandter Rezeptoren, der LDL R Gen Familie. Es sind zwei Arten von Lipidtransportpartikel beschrieben worden, die durch Megalin in Zellen aufgenommen werden. Zum einen werden Lipoproteine über ihre Apoproteine von Megalin erkannt und endozytiert. Zum anderen nimmt Megalin die hydrophoben Vitamine A und D über ihre Carrierproteine in ihre Zielzellen auf. Es handelt sich um Vitamin D bindendes Protein (DBP) und Retinol bindendes Protein (RBP). Zweck dieser Arbeit war es zu untersuchen, ob die Endozytose von Steroidcarriern durch Megalin ein genereller Mechanismus ist oder ob DBP und RBP Ausnahmen darstellen. Hierzu wurden exemplarisch drei Carrierproteine (24p3, Apo D und CCSP) für Steroide ausgesucht, die in Megalin-exprimierende Gewebe aufgenommen werden. Der (rekombinante) Retinolcarrier 23p3 zeigte bei surface plasmon resonance Analysen keine direkte Bindung an Megalin. Der Progesteron-Carrier Apo D hingegen bindet Megalin, ferner konnte in Zellkulturversuchen Endozytose und lysosomale Degradation von Apo D in Megalin-exprimierende Zellen nachgewiesen werden. Auch der Progesteron-Carrier CCSP wird durch Megalin in Zellen aufgenommen, allerdings ist zur Endozytose von CCSP ein Co-Rezeptor notwendig. Mit dieser Arbeit ist die erste in vivo-Beschreibung eines dualen Rezeptorsystems aus Megalin und einem peripheren Membranprotein namens Cubilin gelungen, welches u.a. im proximalen Tubulus der Niere existiert. Abschließend wurde exemplarisch für ein Steroidhormon-abhängiges Gewebe der murine Uterus hinsichtlich seiner Megalin-Expression untersucht. Es konnte ein bereits bekannter Ligand Megalins, das Glykoprotein Laktoferrin, aus der uterinen, luminalen Flüssigkeit aufgereinigt werden. Ferner konnte gezeigt werden, dass die Expression von Laktoferrin im Uterus strenger hormoneller Kontrolle unterliegt.
The endozytic receptor Megalin belongs to a group of structurally and functionally related receptors called LDL R gene family. Two different types of lipid particles are taken up by Megalin into target cells. The first type, lipoproteins are recognized and internalized by Megalin via their apoproteins. In addition, Megalin mediates the endocytosis of the lipophilic vitamins A and D into target cells by means of their carrier proteins. These proteins are the vitamin D binding protein (DBP) and retinal binding protein (RBP). The aim of the investigations was to determine, if the endocytosis of steroid hormone carriers by Megalin is a common occurrence or restricted only to DBP and RBP. Therefore, three carrier proteins for steroids (24p3, Apo D and CCSP) were chosen as an example. All of them are known to be taken up in Megalin expressing tissues. In surface plasmon resonance analysis recombinant 24p3, a carrier of retinol, showed no affinity to Megalin. Whereas the progesterone carrier Apo D bound to Megalin. Furthermore, it was endozytosed and degraded in lysosomes by Megalin expressing cells. The cellular uptake of the progesterone carrier CCSP is mediated by Megalin as well, however a co-receptor is needed. This work demonstrates for the first time the existence of a dual receptor pathway consisting of Megalin and a peripheral membrane protein named Cubilin in vivo. This systems is functional in addition to other tissues in the proximal tubule of the kidney. Finally, the Megalin expression in the murine uterus as an example of a steroid dependent tissue was investigated. Lactoferrin a known Megalin ligand was purified from the luminal uterine fluid. Furthermore, Lactoferrin expression in the uterus was shown to be under tight hormonal control.
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Eimers, Meike [Verfasser]. "Die Rolle des Endozytoserezeptors Megalin (GP330) bei der Pathogenese progredienter Nephropathien / Meike Eimers." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023623463/34.

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Books on the topic "Megalin"

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József, Bakucz. Megalit. Budapest: Magyar Műhely, 1994.

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Fakinou, Evgenia. I megali prasini. Athens: Kastoniotis, 1987.

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Fred, Beltran, ed. Megalex. Barcelona: Mondadori, 2010.

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Tzur, Ygal. Meṭayelim, megalim ṿe-yotsrim. Yerushalayim: Karṭa, 2003.

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ʻIdo, Nir. Yesh sodot she-lo megalim. Hertseliyah: Sifre Niv, 2017.

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Sidēropoulos, Polyneikēs. Megalē gē. Athena: Vivliopōleion tēs "Hestias", 1999.

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Krzak, Zygmunt. Megality Europy. Warszawa: Wydawn. Nauk. PWN, 1994.

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Galam, Liz. Megaleh ṭefaḥ. Tel Aviv: Tamuz, 2005.

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Paradissis, Chrysa. I megali Magiriki ke Zacharoplastiki. 2nd ed. Marousi: Terzopoulou, 1986.

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Panayiotakos, Konstantinos. Kypros o fakelos tis megalis prodosias. Athens: Filippotis, 1986.

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Book chapters on the topic "Megalin"

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Asanuma, Katsuhiko. "Podocyte Injury and Significance of Urinary Podocalyxin and Megalin." In Pathogenesis and Treatment in IgA Nephropathy, 89–96. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55588-9_6.

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Christensen, E. I., and R. Nielsen. "Role of megalin and cubilin in renal physiology and pathophysiology." In Reviews of Physiology, Biochemistry and Pharmacology, 1–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/112_0604.

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Birn, H., M. Leboulleux, S. K. Moestrup, P. M. Ronco, P. Aucouturier, and E. I. Christensen. "Megalin, cubilin and immunoglobulin light chains: receptor-mediated uptake of light chains in kidney proximal tubule." In Monoclonal Gammopathies and the Kidney, 37–48. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-0191-4_4.

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Clewley, Jonathan P., and Catherine Arnold. "MEGALIGN." In Sequence Data Analysis Guidebook, 119–29. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1385/0-89603-358-9:119.

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Hernández Cornejo, Gerardo David, Iris Natzielly Serratos Álvarez, César Millán-Pacheco, Jonathan Osiris Vicente-Escobar, and Norma Castañeda-Villa. "A Comparative Study on the Interaction of an Ototoxic and an Otoprotective with the Megalin Receptor Associated with Hearing Loss." In IFMBE Proceedings, 145–52. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-18256-3_15.

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Weik, Martin H. "megabit." In Computer Science and Communications Dictionary, 998. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_11304.

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Sinha, Rajiv. "The Kosi Megafan: The Best-known Himalayan Megafan." In World Geomorphological Landscapes, 151–56. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8029-2_14.

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Weik, Martin H. "megabit data service." In Computer Science and Communications Dictionary, 998. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_11305.

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Arnold, Lorna, and Katherine Pyne. "The Megaton Mission." In Britain and the H-Bomb, 84–94. London: Palgrave Macmillan UK, 2001. http://dx.doi.org/10.1057/9780230599772_7.

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Prijs, Leo. "Perl, Joseph: Megalle Temirin." In Kindlers Literatur Lexikon (KLL), 1–2. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_14751-1.

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Conference papers on the topic "Megalin"

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Oktem, Gulperi. "Insignificant association between megalin expression in prostate cancer tissue and prostate cancer stem cells." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-122.

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Alberro, A., LC Mazzocchi, CU Vohwinkel, W. Seeger, and I. Vadasz. "TGF-β impairs protein clearance by promoting phosphorylation, endocytosis, ubiquitination and degradation of megalin in alveolar epithelial cells." In Herbsttagung der Sektionen Zellbiologie und Infektiologie und Tuberkulose der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0037-1615338.

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Valarezo, Gabriela, Victoria Ortega-Hernández, Gonzalo Escobar-Massú, Wanda Fernández, María Paz Marzolo, and Pilar Carvallo. "Abstract 1440: Vitamin D uptake and metabolism in breast cancer tumors: Differential expression of megalin, VDR, CYP27B1 and CYP24A." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1440.

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Mazzocchi, LC, CU Vohwinkel, W. Seeger, and I. Vadász. "TGF-β reduces megalin cell surface stability by promoting shedding and subsequent transcriptional downregulation of the receptor in alveolar epithelial cells." In Herbsttagung der Sektionen Zellbiologie und Infektiologie und Tuberkulose der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0037-1615332.

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Garcia, Jason, Zachary Richards, Morgan Zenner, Yancai Wang, Peter Gann, Gail Prins, and Larisa Nonn. "Abstract B094: Regulation of megalin by vitamin D as the mechanism for differential levels of intra-prostatic androgens between African American and Caucasian men." In Abstracts: Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; September 20-23, 2019; San Francisco, CA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp19-b094.

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Talebi, Seyed Mohammadjavad Seyed, Ardalan Amiri Sani, Stefan Saroiu, and Alec Wolman. "MegaMind." In MobiSys '21: The 19th Annual International Conference on Mobile Systems, Applications, and Services. New York, NY, USA: ACM, 2021. http://dx.doi.org/10.1145/3458864.3467962.

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Maidens, Jimmy, Philippe Denis, and Gianni Aliotti. "Megamind." In ACM SIGGRAPH 2011 Talks. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2037826.2037868.

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Rost, Krzysztof, Greg Hart, and Scott Peterson. ""MegaMind"." In ACM SIGGRAPH 2011 Talks. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/2037826.2037916.

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Moreno-Jiménez, Luis-Gil, and Juan-Manuel Torres-Moreno. "Megalite: A New Spanish Literature Corpus for NLP Tasks." In 8th International Conference on Artificial Intelligence and Applications (AIAP 2021). AIRCC Publishing Corporation, 2021. http://dx.doi.org/10.5121/csit.2021.110109.

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In this work we introduce the Spanish Literary corpus MegaLite, a new corpus well adapted to Natural Language Processing (NLP), Computational Creativity (CC), Text generation and others studies. We address the creation of this corpus of literary documents to evaluate or design algorithms in automatic text generation, classification, stylometry and rhetorical analysis, sentiment detection, among other tasks. We have constituted this corpus manually in order to avoir genre classification errors. Near of 5 200 works on the genres narrative, poetry and plays constitute this corpus. Some statistics and applications of MegaLite corpus are presented and discussed. The MegaLite corpus will be available to the community as a free resource, under several adequate formats.
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KESER, Ulvi. "ATATÜRK DÖNEMİ TÜRK DIŞ SİYASETİNDE AKDENİZ VE KIBRIS ÜZERİNE BİR DEĞERLENDİRME." In 9. Uluslararası Atatürk Kongresi. Ankara: Atatürk Araştırma Merkezi Yayınları, 2021. http://dx.doi.org/10.51824/978-975-17-4794-5.84.

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Anadolu’da sürdürülen Milli Mücadele’nin 9 Eylül 1922 itibarıyla tamamlanması ve hemen ardından kurulan Türkiye Cumhuriyeti devletiyle birlikte Türk dış politikasında “Yurtta Sulh, Cihanda Sulh” anlayışı benimsenir ve ülkenin dış politikasında bu anlayış ana ekseni oluşturur ve yeni kurulan Türk devleti komşu devletlerin topraklarında gözü olmadığı, yayılmacı bir siyaset gütmediği ve toprak bütünlüğüne saygılı bütün devletlerle iyi komşuluk ilişkileri içerisinde olduğunu göstermiştir. 1922-1938 sürecinde Akdeniz ve Kıbrıs adası ise Türk dış politikasında çok özel bir yere sahiptir. Bu bilimsel araştırma kapsamında özellikle Doğu Akdeniz’in stratejik önemi, Kıbrıs adası ve Kıbrıslı Türklerin durumu, Yunanların ve Kıbrıslı Rumların adayı Yunanlaştırmak maksadıyla yürüttükleri Megali İdea ve Enosis çabaları karşısında Atatürk’ün dış politikada bu bölgeye bakış açısı mercek altına yatırılacaktır. Ayrıca bu dönemde Kıbrıs ve Kıbrıslı Türklere yönelik yardım faaliyetleri, İngiltere ve Yunanistan tarafından yapılan bilgi kirliliği ve psikolojik algı operasyonları karşısında Türkiye’nin yaklaşımı, Yunanistan ve Kıbrıslı Rumların Megali İdea ve Enosis çabaları karşısında Akdeniz ve Kıbrıs’a yönelik hamleler ortaya konulacaktır.
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Reports on the topic "Megalin"

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Wong, Ho-Lun. Megalin-Mediated Oligonucleotide Trafficking for Breast Cancer Chemosensitization. Fort Belvoir, VA: Defense Technical Information Center, August 2010. http://dx.doi.org/10.21236/ada542623.

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Novlick, Leonard R. Thirty-Four Megabit Four-Channel Multiplexer. Fort Belvoir, VA: Defense Technical Information Center, October 1985. http://dx.doi.org/10.21236/adb096831.

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Esquibel, Brian. 2019 Megasun Illumination System Modifications and Operating Procedure Updates. Office of Scientific and Technical Information (OSTI), March 2021. http://dx.doi.org/10.2172/1774390.

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Yong, Dai. Final Report on MEGAPIE Target Irradiation and Post-Irradiation Examination. Office of Scientific and Technical Information (OSTI), June 2015. http://dx.doi.org/10.2172/1188406.

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Lee, Maxwell. Peer Review of Megan Splettstoesser by Maxwell Lee. Office of Scientific and Technical Information (OSTI), August 2015. http://dx.doi.org/10.2172/1213148.

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Splettstoesser, Megan. Peer review of Ryan Dungee's presentation by Megan Splettstoesser. Office of Scientific and Technical Information (OSTI), September 2015. http://dx.doi.org/10.2172/1214430.

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Gohar, Y. MEGAPIE analytical support task : characterization of lead-bismuth eutectic and sodium-cooled tungsten target materials for accelerator driven systems. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/822581.

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Schmidt-Sane, Megan, Tabitha Hrynick, and Eva Niederberger. Community Resilience: Key Concepts and their Applications to Epidemic Shocks. Institute of Development Studies (IDS), January 2021. http://dx.doi.org/10.19088/sshap.2021.003.

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The COVID-19 pandemic has exposed long-standing social inequalities and vulnerabilities, with the most disadvantaged and marginalised groups bearing the greatest health, social, and economic burdens. Beyond documenting these vulnerabilities, there is a need to mitigate them and support the resilience of marginalised communities. ‘Community resilience’ can bolster community capacity to cope with the pressures of various shocks; this brief explores how its concepts can be applied to epidemics. It reviews the grey and academic literature on different approaches to community resilience. It covers 1) terminology, 2) lessons from practice, 3) the context of community resilience, 4) a systems approach, and 5) key human and social capacities. Social justice, inequality, equity, and fairness are highlighted as themes in need of further development for resilience as it relates to epidemic preparedness and response. This brief was developed for SSHAP by IDS (led by Megan Schmidt-Sane with Tabitha Hrynick) with Anthrologica (Eva Niederberger).
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Schmidt-Sane, Megan, Tabitha Hrynick, and Eva Niederberger. Community Resilience: Key Concepts and their Applications to Epidemic Shocks. Institute of Development Studies (IDS), February 2021. http://dx.doi.org/10.19088/sshap.2021.027.

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The COVID-19 pandemic has exposed long-standing social inequalities and vulnerabilities, with the most disadvantaged and marginalised groups bearing the greatest health, social, and economic burdens. Beyond documenting these vulnerabilities, there is a need to mitigate them and support the resilience of marginalised communities. ‘Community resilience’ can bolster community capacity to cope with the pressures of various shocks; this brief explores how its concepts can be applied to epidemics. It reviews the grey and academic literature on different approaches to community resilience. It covers 1) terminology, 2) lessons from practice, 3) the context of community resilience, 4) a systems approach, and 5) key human and social capacities. Social justice, inequality, equity, and fairness are highlighted as themes in need of further development for resilience as it relates to epidemic preparedness and response. This brief was developed for SSHAP by IDS (led by Megan Schmidt-Sane with Tabitha Hrynick) with Anthrologica (Eva Niederberger).
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Schmidt-Sane, Megan, Tabitha Hrynick, and Eva Niederberger. Community Resilience: Key Concepts and their Applications to Epidemic Shocks. Institute of Development Studies (IDS), January 2021. http://dx.doi.org/10.19088/sshap.2021.026.

Full text
Abstract:
The COVID-19 pandemic has exposed long-standing social inequalities and vulnerabilities, with the most disadvantaged and marginalised groups bearing the greatest health, social, and economic burdens. Beyond documenting these vulnerabilities, there is a need to mitigate them and support the resilience of marginalised communities. ‘Community resilience’ can bolster community capacity to cope with the pressures of various shocks; this brief explores how its concepts can be applied to epidemics. It reviews the grey and academic literature on different approaches to community resilience. It covers 1) terminology, 2) lessons from practice, 3) the context of community resilience, 4) a systems approach, and 5) key human and social capacities. Social justice, inequality, equity, and fairness are highlighted as themes in need of further development for resilience as it relates to epidemic preparedness and response. This brief was developed for SSHAP by IDS (led by Megan Schmidt-Sane with Tabitha Hrynick) with Anthrologica (Eva Niederberger).
APA, Harvard, Vancouver, ISO, and other styles
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