Journal articles on the topic 'Megalin'
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Lou, Xiaojing, Tammie McQuistan, Robert A. Orlando, and Marilyn Gist Farquhar. "GAIP, GIPC and Gαi3 are Concentrated in Endocytic Compartments of Proximal Tubule Cells: Putative Role in Regulating Megalin’s Function." Journal of the American Society of Nephrology 13, no. 4 (April 2002): 918–27. http://dx.doi.org/10.1681/asn.v134918.
Full textRADER, KATHERINE, ROBERT A. ORLANDO, XIAOJING LOU, and MARILYN GIST FARQUHAR. "Characterization of ANKRA, a Novel Ankyrin Repeat Protein that Interacts with the Cytoplasmic Domain of Megalin." Journal of the American Society of Nephrology 11, no. 12 (December 2000): 2167–78. http://dx.doi.org/10.1681/asn.v11122167.
Full textTakeda, Tetsuro, Hajime Yamazaki, and Marilyn G. Farquhar. "Identification of an apical sorting determinant in the cytoplasmic tail of megalin." American Journal of Physiology-Cell Physiology 284, no. 5 (May 1, 2003): C1105—C1113. http://dx.doi.org/10.1152/ajpcell.00514.2002.
Full textHosojima, Michihiro, Hiroyoshi Sato, Keiko Yamamoto, Ryohei Kaseda, Taeko Soma, Asako Kobayashi, Akiyo Suzuki, et al. "Regulation of Megalin Expression in Cultured Proximal Tubule Cells by Angiotensin II Type 1A Receptor- and Insulin-Mediated Signaling Cross Talk." Endocrinology 150, no. 2 (February 1, 2009): 871–78. http://dx.doi.org/10.1210/en.2008-0886.
Full textGravotta, Diego, Andres Perez Bay, Caspar T. H. Jonker, Patrick J. Zager, Ignacio Benedicto, Ryan Schreiner, Paulo S. Caceres, and Enrique Rodriguez-Boulan. "Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes." Molecular Biology of the Cell 30, no. 14 (July 2019): 1716–28. http://dx.doi.org/10.1091/mbc.e18-12-0811.
Full textSun, Yuan, Alexandre Goes Martini, Manoe J. Janssen, Ingrid M. Garrelds, Rosalinde Masereeuw, Xifeng Lu, and A. H. Jan Danser. "Megalin." Hypertension 75, no. 5 (May 2020): 1242–50. http://dx.doi.org/10.1161/hypertensionaha.120.14845.
Full textSun, Y., I. M. Garrelds, X. Lu, and A. Danser. "MEGALIN." Journal of Hypertension 37 (July 2019): e134. http://dx.doi.org/10.1097/01.hjh.0000571732.76261.b9.
Full textKlassen, R. Bryan S., Patricia L. Allen, Vecihi Batuman, Kimberly Crenshaw, and Timothy G. Hammond. "Light chains are a ligand for megalin." Journal of Applied Physiology 98, no. 1 (January 2005): 257–63. http://dx.doi.org/10.1152/japplphysiol.01090.2003.
Full textWen, Lu, Pia K. Andersen, Dina M. U. Husum, Rikke Nørregaard, Zhanzheng Zhao, Zhangsuo Liu, and Henrik Birn. "MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction." American Journal of Physiology-Renal Physiology 313, no. 2 (August 1, 2017): F210—F217. http://dx.doi.org/10.1152/ajprenal.00585.2016.
Full textNagai, Junya, Hiroaki Tanaka, Naoki Nakanishi, Teruo Murakami, and Mikihisa Takano. "Role of megalin in renal handling of aminoglycosides." American Journal of Physiology-Renal Physiology 281, no. 2 (August 1, 2001): F337—F344. http://dx.doi.org/10.1152/ajprenal.2001.281.2.f337.
Full textStorm, Tina, Erik I. Christensen, Julie Nelly Christensen, Tine Kjaergaard, Niels Uldbjerg, Agnete Larsen, Bent Honoré, and Mette Madsen. "Megalin Is Predominantly Observed in Vesicular Structures in First and Third Trimester Cytotrophoblasts of the Human Placenta." Journal of Histochemistry & Cytochemistry 64, no. 12 (October 23, 2016): 769–84. http://dx.doi.org/10.1369/0022155416672210.
Full textNagai, Masaaki, Timo Meerloo, Tetsuro Takeda, and Marilyn Gist Farquhar. "The Adaptor Protein ARH Escorts Megalin to and through Endosomes." Molecular Biology of the Cell 14, no. 12 (December 2003): 4984–96. http://dx.doi.org/10.1091/mbc.e03-06-0385.
Full textGonzalez-Villalobos, Romer, R. Bryan Klassen, Patricia L. Allen, L. G. Navar, and Timothy G. Hammond. "Megalin binds and internalizes angiotensin II." American Journal of Physiology-Renal Physiology 288, no. 2 (February 2005): F420—F427. http://dx.doi.org/10.1152/ajprenal.00243.2004.
Full textZheng, Gang, Michele Marino, Jun Zhao, and Robert T. McCluskey. "Megalin (gp330): A Putative Endocytic Receptor for Thyroglobulin (Tg)." Endocrinology 139, no. 3 (March 1, 1998): 1462–65. http://dx.doi.org/10.1210/endo.139.3.5978.
Full textNagai, J., E. I. Christensen, S. M. Morris, T. E. Willnow, J. A. Cooper, and R. Nielsen. "Mutually dependent localization of megalin and Dab2 in the renal proximal tubule." American Journal of Physiology-Renal Physiology 289, no. 3 (September 2005): F569—F576. http://dx.doi.org/10.1152/ajprenal.00292.2004.
Full textKlassen, R. Bryan, Kimberly Crenshaw, Renata Kozyraki, Pierre J. Verroust, Laura Tio, Sílvia Atrian, Patricia L. Allen, and Timothy G. Hammond. "Megalin mediates renal uptake of heavy metal metallothionein complexes." American Journal of Physiology-Renal Physiology 287, no. 3 (September 2004): F393—F403. http://dx.doi.org/10.1152/ajprenal.00233.2003.
Full textSuzuki, Takahiro, Hiroaki Yamaguchi, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, and Ken Iseki. "Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin." Antimicrobial Agents and Chemotherapy 57, no. 12 (October 7, 2013): 6319–24. http://dx.doi.org/10.1128/aac.00254-13.
Full textGamat, M., G. Shaw, and M. B. Renfree. "170. THE ROLE OF MEGALIN IN PROSTATE DEVELOPMENT OF THE MOUSE." Reproduction, Fertility and Development 22, no. 9 (2010): 88. http://dx.doi.org/10.1071/srb10abs170.
Full textZIAK, MARTIN, DONTSCHO KERJASCHKI, MARILYN G. FARQUHAR, and JÜRGEN ROTH. "Identification of Megalin as the Sole Rat Kidney Sialoglycoprotein Containing Poly α2,8 Deaminoneuraminic Acid." Journal of the American Society of Nephrology 10, no. 2 (February 1999): 203–9. http://dx.doi.org/10.1681/asn.v102203.
Full textKhan, Sono S., Martin Petkovich, Rachel M. Holden, and Michael A. Adams. "Megalin and Vitamin D Metabolism—Implications in Non-Renal Tissues and Kidney Disease." Nutrients 14, no. 18 (September 7, 2022): 3690. http://dx.doi.org/10.3390/nu14183690.
Full textDahlke, Eileen, Yaman Anan, Lea Maximiliane Klie, Ariane Elisabeth Hartkopf, and Franziska Theilig. "Megalin Orchestrates FcRn Endocytosis and Trafficking." Cells 12, no. 1 (December 22, 2022): 53. http://dx.doi.org/10.3390/cells12010053.
Full textCzekay, R. P., R. A. Orlando, L. Woodward, E. D. Adamson, and M. G. Farquhar. "The expression of megalin (gp330) and LRP diverges during F9 cell differentiation." Journal of Cell Science 108, no. 4 (April 1, 1995): 1433–41. http://dx.doi.org/10.1242/jcs.108.4.1433.
Full textKurosaki, Yoshifumi, Akemi Imoto, Fumitaka Kawakami, Masanori Yokoba, Tsuneo Takenaka, Takafumi Ichikawa, Masato Katagiri, and Naohito Ishii. "Oxidative stress increases megalin expression in the renal proximal tubules during the normoalbuminuric stage of diabetes mellitus." American Journal of Physiology-Renal Physiology 314, no. 3 (March 1, 2018): F462—F470. http://dx.doi.org/10.1152/ajprenal.00108.2017.
Full textFaber, Kirsten, Vibeke Hvidberg, Søren K. Moestrup, Björn Dahlbäck, and Lars Bo Nielsen. "Megalin Is a Receptor for Apolipoprotein M, and Kidney-Specific Megalin-Deficiency Confers Urinary Excretion of Apolipoprotein M." Molecular Endocrinology 20, no. 1 (January 1, 2006): 212–18. http://dx.doi.org/10.1210/me.2005-0209.
Full textGonzalez-Villalobos, Romer, R. Bryan Klassen, Patricia L. Allen, Kelly Johanson, Chasity B. Baker, Hiroyuki Kobori, L. G. Navar, and Timothy G. Hammond. "Megalin binds and internalizes angiotensin-(1–7)." American Journal of Physiology-Renal Physiology 290, no. 5 (May 2006): F1270—F1275. http://dx.doi.org/10.1152/ajprenal.00164.2005.
Full textGamat, M., M. B. Renfree, A. J. Pask, and G. Shaw. "230. Megalin, RAP and Nkx3.1 expression in the developing reproductive tract of a marsupial, the tammar wallaby." Reproduction, Fertility and Development 20, no. 9 (2008): 30. http://dx.doi.org/10.1071/srb08abs230.
Full textOLEINIKOV, Andrew V., Jun ZHAO, and Sudesh P. MAKKER. "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin." Biochemical Journal 347, no. 3 (April 25, 2000): 613–21. http://dx.doi.org/10.1042/bj3470613.
Full textMazzocchi, Luciana C., Christine U. Vohwinkel, Konstantin Mayer, Susanne Herold, Rory E. Morty, Werner Seeger, and István Vadász. "TGF-β inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin." American Journal of Physiology-Lung Cellular and Molecular Physiology 313, no. 5 (November 1, 2017): L807—L824. http://dx.doi.org/10.1152/ajplung.00569.2016.
Full textBIRN, HENRIK, HENRIK VORUM, PIERRE J. VERROUST, SØREN K. MOESTRUP, and ERIK ILSØ CHRISTENSEN. "Receptor-Associated Protein Is Important for Normal Processing of Megalin in Kidney Proximal Tubules." Journal of the American Society of Nephrology 11, no. 2 (February 2000): 191–202. http://dx.doi.org/10.1681/asn.v112191.
Full textAhuja, Rajiv, Raghunatha Yammani, Joseph A. Bauer, Seema Kalra, Shakuntla Seetharam, and Bellur Seetharam. "Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability." Biochemical Journal 410, no. 2 (February 12, 2008): 301–8. http://dx.doi.org/10.1042/bj20070919.
Full textMahadevappa, Ravikiran, Rikke Nielsen, Erik Ilsø Christensen, and Henrik Birn. "Megalin in acute kidney injury: foe and friend." American Journal of Physiology-Renal Physiology 306, no. 2 (January 15, 2014): F147—F154. http://dx.doi.org/10.1152/ajprenal.00378.2013.
Full textGburek, Jakub, Henrik Birn, Pierre J. Verroust, Boguslawa Goj, Christian Jacobsen, Søren K. Moestrup, Thomas E. Willnow, and Erik I. Christensen. "Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin." American Journal of Physiology-Renal Physiology 285, no. 3 (September 2003): F451—F458. http://dx.doi.org/10.1152/ajprenal.00062.2003.
Full textShah, Mehul, Oscar Y. Baterina, Vanessa Taupin, and Marilyn G. Farquhar. "ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression." Journal of Cell Biology 202, no. 1 (July 8, 2013): 113–27. http://dx.doi.org/10.1083/jcb.201211110.
Full textLi, Yuanli, Rong Cong, and Daniel Biemesderfer. "The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells." American Journal of Physiology-Cell Physiology 295, no. 2 (August 2008): C529—C537. http://dx.doi.org/10.1152/ajpcell.00037.2008.
Full textYammani, Raghunatha R., Mukut Sharma, Shakuntla Seetharam, John E. Moulder, Nancy M. Dahms, and Bellur Seetharam. "Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 2 (August 1, 2002): R339—R346. http://dx.doi.org/10.1152/ajpregu.00752.2001.
Full textKasabri, Violet, Amal Akour, Nailya Bulatova, Maysa Suyagh, Al Motassem Yousef, Hussein Al Hawari, Sameeha Al Shelleh, Jameel Bzour, and Hiba Fahmawi. "A Pre-Post Study of Vitamin D Supplement Effects on Urinary Megalin: The Emerging Predictive Role of Megalin in Diabetic Nephropathy Progression." Endocrine, Metabolic & Immune Disorders - Drug Targets 20, no. 9 (November 5, 2020): 1552–57. http://dx.doi.org/10.2174/1871530320666200525012811.
Full textPATRIE, KEVIN M., ANDREW J. DRESCHER, MEERA GOYAL, ROGER C. WIGGINS, and BEN MARGOLIS. "The Membrane-Associated Guanylate Kinase Protein MAGI-1 Binds Megalin and Is Present in Glomerular Podocytes." Journal of the American Society of Nephrology 12, no. 4 (April 2001): 667–77. http://dx.doi.org/10.1681/asn.v124667.
Full textCHRISTENSEN, ERIK ILSØ, JAN ØIVIND MOSKAUG, HENRIK VORUM, CHRISTIAN JACOBSEN, THOMAS E. GUNDERSEN, ANDERS NYKJÆR, RUNE BLOMHOFF, THOMAS E. WILLNOW, and SØREN K. MOESTRUP. "Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol." Journal of the American Society of Nephrology 10, no. 4 (April 1999): 685–95. http://dx.doi.org/10.1681/asn.v104685.
Full textKapetanaki, Stefania, Ashok Kumar Kumawat, Katarina Persson, and Isak Demirel. "TMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling." International Journal of Molecular Sciences 23, no. 16 (August 9, 2022): 8856. http://dx.doi.org/10.3390/ijms23168856.
Full textLARSSON, Mårten, Göran HJÄLM, Amos M. SAKWE, Åke ENGSTRÖM, Anna-Stina HÖGLUND, Erik LARSSON, Robert C. ROBINSON, Christian SUNDBERG, and Lars RASK. "Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins." Biochemical Journal 373, no. 2 (July 15, 2003): 381–91. http://dx.doi.org/10.1042/bj20021958.
Full textBirn, Henrik, Thomas E. Willnow, Rikke Nielsen, Anthony G. W. Norden, Christian Bönsch, Søren K. Moestrup, Ebba Nexø, and Erik I. Christensen. "Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B12." American Journal of Physiology-Renal Physiology 282, no. 3 (March 1, 2002): F408—F416. http://dx.doi.org/10.1152/ajprenal.00206.2000.
Full textBryniarski, Mark A., Benjamin M. Yee, Irum Jaffri, Lee D. Chaves, Jin Ah Yu, Xiaowen Guan, Nazanin Ghavam, Rabi Yacoub, and Marilyn E. Morris. "Increased megalin expression in early type 2 diabetes: role of insulin-signaling pathways." American Journal of Physiology-Renal Physiology 315, no. 5 (November 1, 2018): F1191—F1207. http://dx.doi.org/10.1152/ajprenal.00210.2018.
Full textCzekay, R. P., R. A. Orlando, L. Woodward, M. Lundstrom, and M. G. Farquhar. "Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes." Molecular Biology of the Cell 8, no. 3 (March 1997): 517–32. http://dx.doi.org/10.1091/mbc.8.3.517.
Full textLi, Xiao C., and Jia L. Zhuo. "Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin." American Journal of Physiology-Renal Physiology 307, no. 2 (July 15, 2014): F222—F233. http://dx.doi.org/10.1152/ajprenal.00693.2013.
Full textChiu-Ugalde, Jazmin, Franziska Theilig, Thomas Behrends, Julia Drebes, Carolin Sieland, Prema Subbarayal, Josef Köhrle, Annette Hammes, Lutz Schomburg, and Ulrich Schweizer. "Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain." Biochemical Journal 431, no. 1 (September 14, 2010): 103–11. http://dx.doi.org/10.1042/bj20100779.
Full textSaito, Akihiko, Hiroyoshi Sato, Noriaki Iino, and Tetsuro Takeda. "Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium." Journal of Biomedicine and Biotechnology 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/403272.
Full textMarinò, Michele, Luca Chiovato, Nicholas Mitsiades, Francesco Latrofa, David Andrews, Sophia Tseleni-Balafouta, A. Bernard Collins, Aldo Pinchera, and Robert T. McCluskey. "Circulating Thyroglobulin Transcytosed by Thyroid Cells Is Complexed with Secretory Components of Its Endocytic Receptor Megalin*." Journal of Clinical Endocrinology & Metabolism 85, no. 9 (September 1, 2000): 3458–67. http://dx.doi.org/10.1210/jcem.85.9.6804.
Full textOrlando, R. A., D. Kerjaschki, and M. G. Farquhar. "Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein." Journal of the American Society of Nephrology 6, no. 1 (July 1995): 61–67. http://dx.doi.org/10.1681/asn.v6161.
Full textNorden, Anthony G. W., Marta Lapsley, Takashi Igarashi, Catherine L. Kelleher, Philip J. Lee, Takeshi Matsuyama, Steven J. Scheinman, et al. "Urinary Megalin Deficiency Implicates Abnormal Tubular Endocytic Function in Fanconi Syndrome." Journal of the American Society of Nephrology 13, no. 1 (January 2002): 125–33. http://dx.doi.org/10.1681/asn.v131125.
Full textFowlkes, John L., R. Clay Bunn, Gael E. Cockrell, Lindsey M. Clark, Elizabeth C. Wahl, Charles K. Lumpkin, and Kathryn M. Thrailkill. "Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes." Experimental Diabetes Research 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/269378.
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