Journal articles: 'Megaplex'

1

Rich, Wilbur C. "Who Lost the Megaplex?" Review of Policy Research 15, no. 1 (March 1998): 103–14. http://dx.doi.org/10.1111/j.1541-1338.1998.tb00756.x.

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Sadoff, D. F. "Marketing Jane Austen at the Megaplex." Novel: A Forum on Fiction 43, no. 1 (March 1, 2010): 83–92. http://dx.doi.org/10.1215/00295132-2009-067.

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Hummel, Susanne, Tobias Schultes, Barbara Bramanti, and Bernd Herrmann. "Ancient DNA profiling by megaplex amplications." Electrophoresis 20, no. 8 (January 1, 1999): 1717–21. http://dx.doi.org/10.1002/(sici)1522-2683(19990101)20:8<1717::aid-elps1717>3.0.co;2-d.

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Acland, Charles R. "Cinemagoing and the Rise of the Megaplex." Television & New Media 1, no. 3 (August 2000): 355–82. http://dx.doi.org/10.1177/152747640000100306.

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Acland, Charles R. "Cinemagoing and the Rise of the Megaplex." Television & New Media 1, no. 4 (November 2000): 375–402. http://dx.doi.org/10.1177/152747640000100402.

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Meuzelaar, Linda Strömqvist, Owen Lancaster, J. Paul Pasche, Guido Kopal, and Anthony J. Brookes. "MegaPlex PCR: a strategy for multiplex amplification." Nature Methods 4, no. 10 (September 16, 2007): 835–37. http://dx.doi.org/10.1038/nmeth1091.

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Briley, Ron. "Cinema Houston: From Nickelodeon to Megaplex (review)." Southwestern Historical Quarterly 112, no. 4 (2009): 456–58. http://dx.doi.org/10.1353/swh.2009.0047.

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Wener, Mark H. "Multiplex, megaplex, index, and complex: the present and future of laboratory diagnostics in rheumatology." Arthritis Research & Therapy 13, no. 6 (2011): 134. http://dx.doi.org/10.1186/ar3498.

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Mautner, Martin E., Mariela Caputo, Santiago Ginart, Tatiana S. Bengochea, and Daniel Corach. "Degraded DNA typing highly improved by a CODIS-CORE + ESS MEGAPLEX based on superprimers." Forensic Science International: Genetics Supplement Series 7, no. 1 (December 2019): 739–41. http://dx.doi.org/10.1016/j.fsigss.2019.10.159.

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Keyser-Tracqui, Christine, Eric Crubézy, Isabelle Clisson, Isabelle Gemmerich, Bertrand Ludes, and Pierre-Henri Giscard. "Megaplex analysis of a Mongolian population from the Egyin Gol site (300 B.C.–300 A.D.)." International Congress Series 1239 (January 2003): 581–84. http://dx.doi.org/10.1016/s0531-5131(02)00556-3.

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Hayman, Casey. "Melle Mel in the Megaplex: Postmodern Performance and the Hip-Hop “Real” in Krush Groove & Beat Street." African American Review 46, no. 1 (2013): 117–32. http://dx.doi.org/10.1353/afa.2013.0016.

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Biassi, Thaís Priscila, Elvira Maria Guerra-Shinohara, Patrícia Natália Silva Moretti, Valeria de Freitas Dutra, Ana Carolina Cabañas-Pedro, Grazielle Mecabo, Gisele W. B. Colleoni, and Maria Stella Figueiredo. "microRNA and Severity of Sickle Cell Anemia." Blood 132, Supplement 1 (November 29, 2018): 3647. http://dx.doi.org/10.1182/blood-2018-99-115315.

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Abstract Background: Sickle cell anemia (SCA) is a complex disease, associated with hemolysis, vaso-occlusion, vascular inflammation and endothelial activation. Significant morbidity and premature mortality are hallmarks of the disease and elevation of tricuspide regurgitant velocity (TRV), determined by doppler-echocardiography, has been associated with higher risk. The identification of biomarkers associated with severity in SCA is desirable. Circulating serum microRNAs (miRNA) are molecular targets studied in different diseases as diagnostic or prognostic markers, however there are few studies in SCA. Purpose: to identify specific signatures of miRNAs in plasma samples of SCA patients according to severity indexes. Methods: Screening of the miRNAs expression was performed in 8 patients. These patients were classified by TRV measure (referred as TRV Score): 4 samples with TVR ≥ 2.5 m/s and 4 with TRV < 2.5 m/s. After extraction of total RNA, the samples were analyzed by real-time PCR using Megaplex RT Human Pool A and Megaplex RTHuman Pool Blife (Thermofisher) comprising 667 distinct miRNAs. Expression Suite Software (Thermofisher) and SPSS were used for analysis. Seventeen miRNAs were differentially expressed between the two groups (p < 0.05) and miR16 was considered as the endogenous candidate. Five differentially expressed miRNAs (miR15b, miR502, miR510, miR544, miR629) were selected for validation in 56 patient samples using TRV Score. Another two severity scores were also used: (a) Organ Injury Score (SLO) - based on the presence or absence of 5 lesions: stroke, TRV ≥ 2.5 m/s, leg ulcers, osteonecrosis, and microalbuminuria (adapted from Afenyi-Annan et al. Transfusion 2008; 48:197) and (b) NIH Bayesian score - available online (http://bios.ugr.es/dss-calculator/). The ROC curve was used to analyze the data of relative expression (2-ΔCT) of each miRNA. Results: Two out of five miRNA, miR510 and miR629, were significantly decreased in more severe patients. The miR510 expression allowed the discrimination of the patients according to TRV Score at the cutoff 0.000331043, sensitivity 71.4%, specificity 73.3% and AUC of 0.825 (95% CI: 0.689-0.962, p = 0.001). The same miRNA was also a good discriminant in the SLO at a cutoff of 0.000331043, sensitivity 77.8%, specificity 72.2% and area under the curve (AUC) of 0.769 (95% CI: 0.666-0.931), p = 0.008. The miR629 was related to severity according to the Bayesian Score at the cutoff of 0.0009854449, sensitivity 66.7%, specificity 75% and AUC of 0.729 (95% CI: 0.552-0.907, p = 0.027). The other miRNAs, miR15b, miR502 and miR544, showed no significant results. Discussion and Conclusions: This is the first study which looks into plasma miRNA as a biomarker of SCA severity. The miR510 regulate Peroxirredoxin-1 (PRDX1), a protein involved in the stress-oxidation. Increased oxidative stress presented in SCA might imply that miR510 has a role in this mechanism. The miR629 appears to be involved in the AKT1 signaling pathway related to Endothelin-1. As it is known, endothelin-1 is increased in SCA and is important in pulmonary hypertension. The miR510 and miR629 appear to be hypoexpressed in patients with more severe SCA, probably with greater importance in the regulation of clinical manifestations associated with vascular disease, although more studies seem to be necessary. Disclosures No relevant conflicts of interest to declare.

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Hanson, Erin K., and Jack Ballantyne. "A Highly Discriminating 21 Locus Y-STR Megaplex System Designed to Augment the Minimal Haplotype Loci for Forensic Casework." Journal of Forensic Sciences 49, no. 1 (2004): 1–12. http://dx.doi.org/10.1520/jfs2003209.

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14

Du, George, Liyou Qiu, Ling Shen, Probhat Sehgal, Yun Shen, Dan Huang, Norman L. Letvin, and Zheng W. Chen. "Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infection." Journal of Immunological Methods 308, no. 1-2 (January 2006): 19–35. http://dx.doi.org/10.1016/j.jim.2005.09.009.

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15

Hummel, Susanne, Barbara Bramanti, Tobias Schultes, Melanie Kahle, Simone Haffner, and Bernd Herrmann. "Megaplex DNA typing can provide a strong indication of the authenticity of ancient DNA amplifications by clearly recognizing any possible type of modern contamination." Anthropologischer Anzeiger 58, no. 1 (March 28, 2000): 15–21. http://dx.doi.org/10.1127/anthranz/58/2000/15.

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16

Campoy, José Antonio, Pedro Martínez-Gómez, David Ruiz, Jasper Rees, and Jean Marc Celton. "Developing Microsatellite Multiplex and Megaplex PCR Systems for High-Throughput Characterization of Breeding Progenies and Linkage Maps Spanning the Apricot (Prunus armeciaca L.) Genome." Plant Molecular Biology Reporter 28, no. 4 (February 18, 2010): 560–68. http://dx.doi.org/10.1007/s11105-010-0186-0.

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17

Petitjean, F. "Mental health in paris: The homeless issue." European Psychiatry 26, S2 (March 2011): 2119. http://dx.doi.org/10.1016/s0924-9338(11)73822-6.

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The Paris population covered, in 2007 2.181.000 inhabitants. This covers the city itself. When adding the surrounding towns, the total figure reaches 6.507.000, more than half the total Ile de France region.A recent study (LAPORTE, 2010) gives an estimate of 21.000 persons being homeless in the Paris megapole. A third of these individuals suffer from severe mental illness, with a prevalence of 13, 2% for psychotic disorders, 6,7% for affective disorders, 12,2% for anxiety and 21% for personality disorders.Psychoactive substances are to of concern for 29% of the homeless population.The author will present data from a two consecutive studies carried out in the Paris megapole concerning the homeless population. (KOVESS, 2001; LAPORTE, 2010).The author will present data from a two consecutive studies carried out in the Paris megapole concerning the homeless population. (KOVESS, 2001; LAPORTE, 2010).

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18

Clarke, Theodore M. "Heavy Duty Camera Bellows for Digital Imaging." Microscopy Today 6, no. 3 (April 1998): 12–13. http://dx.doi.org/10.1017/s1551929500066761.

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My previous article on digital imaging in the April 1997 issue of Microscopy Today noted the use of an Olympus Auto Bellows with a Kodak MegaPlus 1.6i/AB CCD camera for digital photomacrographs equivalent to 4 x 5 Polaroid prints with magnifications between 10X and 50X, The purpose of this article is to document the high resolution obtainable with the bellows system and the design modifications needed to eliminate the plastic dovetail inserts of the Olympus Auto Bellows, which are susceptible to delayed stress cracking when used with a heavier camera like the MegaPlus, Total failure of the dovetail inserts could cause costly damage to the lens and the camera.

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Олександр Білоцерківський and Катерина Кочіна. "ANALISYS OF MANAGEMENT INFORMATION SYSTEMS FOR TRADE ENTERPRISES." Bulletin of the National Technical University "Kharkiv Polytechnic Institute" (economic sciences), no. 1 (December 28, 2021): 50–54. http://dx.doi.org/10.20998/2519-4461.2020.1.50.

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The analysis of management information systems for trade enterprises in Ukraine is considered. The process of a trade enterprise management determines the need to use information systems and technologies. However, the level of information support for Ukrainian trade enterprises remains very low because only 6 % of them actively used systems for customer relationship management. Therefore, the analysis and reasonable selecting of management information systems for trade enterprises is relevant and has practical importance. Analysis of the problem showed that researchers used two ways. The first one is to develop the own information systems. The second one is to use existing systems. The purpose of the article is a comparative analysis of management information systems for trade enterprises and their selection based on rating evaluation. Based on the method of analogy, a methodology for rating evaluation of information systems has been proposed. To check the consistency of expert opinion on the rating of information systems, an expert method was used. Kendall coefficient of concordance has been calculated. A comparative analysis of four information systems such as Bitrix24, Bpm'online, AmoCRM, Megaplan was carried out. Based on the survey, they were selected by fifteen signs. It is determined that the information systems such as bpm online and Bitrix24 have the highest ratings. There have been considered their functionality. Similar results were obtained for six information systems including Megaplan, bpm'online sales, Bitrix24, Amo CRM, 1C and Mango. The consistency degree of expert opinions on the rating of four information systems such as bpm'online sales, Bitrix24, AmoCRM and Megaplan is determined by the expert method. The value of Kendall concordance coefficient of 0.86 indicates a strong consistency of expert opinion, which confirms the preliminary calculations. So, information systems are arranged in the following order: bpm online ranks first, Bitrix24 ranks second, AmoCRM ranks third and Megaplan comes fourth. Thus, according to the results of the rating, the solution of the company Terrasoft «Bpm'online» is the most suitable for satisfying our needs.

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20

LIMA, SHEILA PEREIRA DE, ISMAEL BARRETO DE OLIVEIRA, FRANCISCO FELIPE XAVIER FILHO, and RAPHAEL AQUINO HELEODORO. "A new species of Jeremia Redtenbacher (Phasmatodea: Phasmatidae: Cladomorphinae), a stick insect from the northern Brazilian Amazon Basin." Zootaxa 5399, no. 4 (January 15, 2024): 433–45. http://dx.doi.org/10.11646/zootaxa.5399.4.8.

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A new species of Jeremia Redtenbacher (Phasmatodea: Phasmatidae: Cladomorphinae) is described based on both male and female specimens from the northern Brazilian Amazon Basin and named Jeremia megaplax sp. nov. The new species can be differentiated from other species of this genus by the length of the female subgenital plate, which is two times longer than the length of tergites 8–10. Photos and description from subadult male and not fully developed eggs are also provided. The studied material is deposited at the Invertebrate Collection of the Instituto Nacional de Pesquisas da Amazônia (INPA).

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21

Zanini, L. "Radioprotection calculations for MEGAPIE." Radiation Protection Dosimetry 116, no. 1-4 (December 20, 2005): 95–98. http://dx.doi.org/10.1093/rpd/nci129.

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22

Fazio, Concetta. "Die Flüssigmetall-Neutronenquelle MEGAPIE." Physik in unserer Zeit 38, no. 5 (August 27, 2007): 216–17. http://dx.doi.org/10.1002/piuz.200790063.

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23

Link, Andreas, and Christa E. Müller. "G-Protein-gekoppelte Rezeptoren: intrazelluläre Megaplexe und funktionell selektive Wirkstoffe." Angewandte Chemie 128, no. 52 (October 24, 2016): 16194–96. http://dx.doi.org/10.1002/ange.201609015.

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Wohlmuther, Michael, and Werner Wagner. "PIE preparation of the MEGAPIE target." Journal of Nuclear Materials 431, no. 1-3 (December 2012): 10–15. http://dx.doi.org/10.1016/j.jnucmat.2011.11.024.

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25

Panebianco, Stefano, Klara Berg, Jean-Christophe David, Mohamed Eid, Uwe Filges, Friedrich Gröschel, Arnaud Guertin, et al. "Neutronic characterization of the MEGAPIE target." Annals of Nuclear Energy 36, no. 3 (April 2009): 350–54. http://dx.doi.org/10.1016/j.anucene.2008.12.013.

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26

Chabod, Sébastien, Christophe Blandin, Frédéric Chartier, Gabriele Fioni, Yann Foucher, Alain Letourneau, Frédéric Marie, and Jean-Christian Toussaint. "Neutron flux characterisation of MEGAPIE target." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 562, no. 2 (June 2006): 618–20. http://dx.doi.org/10.1016/j.nima.2006.02.074.

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de Andrade, Tathiana Azevedo, Adriane Feijo Evangelista, Natalia Morais Borges, Antonio Hugo Froes Campos, Claudia Camillo, Fernando A. Soares, Jose Vassallo, et al. "Micro-RNA Expression Profile Reveals MiR-222 As a Potential Biomarker For EBV-Positive Diffuse Large B-Cell Lymphoma." Blood 122, no. 21 (November 15, 2013): 4269. http://dx.doi.org/10.1182/blood.v122.21.4269.4269.

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Abstract Background EBV+ diffuse large B-cell lymphoma of the elderly (EBV+DLBCLe) is considered a provisional entity in the latest World Health Organization classification. It affects individuals older than 50 years without prior documented immunodeficiency.This disorder has unfavorable clinical course even after the advent of immunotherapy associated to anthracycline-based chemotherapy. It is linked to Epstein-Barr virus and the physiopathology is related to the presence of the virus itself, senescence and immunological deterioration. Currently there is not a characteristic pattern of expression of microRNAs in EBV+DLBCLe. Aims To characterize a signature profile for this new entity and to explore microRNAs as biomarkers and potential alternative therapeutic targets for EBV+DLBCLe. Methods 124 cases of patients of DLBCL were treated at Hospital Sao Paulo UNIFESP/EPM between 2000 to 2010 and had paraffin blocks available for immunohistochemical and molecular analyses. Seventy-one of 124 patients were more than 50 years and were potential candidates to be considered EBV+DLBCLe (pilot study). In situ hybridization was used for EBV detection (EBER1, Invitrogen) in a tissue microarray slide. Total RNA was obtained from tumor slides using Recover All Total Nucleic Acid Isolation kit (Applied Biosystems). We obtained cDNAs using Megaplex Pools for microRNA Expression (Applied Biosystems). The cDNA was inserted into two platforms containing 384 human microRNA each (Taqman Low Density Arrays) on 7900 Real Time PCR Systems (Applied Biosystems). Data analyses were made in mathematical-statistical environment “R”. The normalization method 2-deltaCt was performed using the endogenous RNU48, and it was identified as the most stable among samples by software Normfinder. It was also used RNU6 recommended by the manufacturer, in a comparative way. MicroRNAs differentially expressed in EBV+ group compared to EBV negative were identified by means of nonparametric tests rank products (RankProd) and Wilcoxon rank-sum (R-Stats). We considered differentially expressed microRNAs which average fold change above or below 1.5.After, real-time quantitative PCR was performed through 7500 Real time PCR Systems (Applied Biosystems) using TaqMan Small RNA kit assays and normalized with RNU48. Results 8.5% of cases of DLBCL were considered EBV+DLBCLe after ISH for EBV. 53.1% of the pilot study were considered GCB and 43.9% non-GCB according to Hans et al. algorithm (2004); 73.7% were classified as worse prognosis (groups 3 and 4) according to Salles et. al(2011) model combining IPI and immunohistochemical markers (bcl-2 and Ki67).We selected four of EBV+ and four of EBV negative samples matched by age, gender, stage and IPI to be analyzed in the PCR platforms. We found 10 deregulated microRNAs among the two groups. However, only seven microRNAs achieved statistically significant differences and would be the start point of a microRNA signature profile proposal to be validated in a larger multicentric cohort (total of 29 EBV+DLBCLe versus 65 DLBCL). Among them let-7g, miR-126, miR-146a, miR-146b, miR-150 and miR-155 were overexpressed in EBV+DLBCLe comparing to EBV-negative DLBCL whereas miR-151 was underexpressed. After validation in 29 EBV+DLBCLe (including 23 new cases) and 65 EBV negative cases we confirmed overexpression of miR-126 in 75.8% (median 2.14 vs 0.14,p< 0.0001), miR-146a in 62% (median 1.94 vs 0.49, p = 0.0035) ,miR-146b in 51.7% (median 1.51 vs 0.11 , p< 0.0001),miR-150 in 96.5 % (median 20.54 vs 2.56,p< 0.0001) and miR-222 in 23,8% of cases (median 0.67 vs 0.08,p< 0.0001,Mann-Whitney) and also confirmed underexpression of miR-151 in 96% of EBV+DLBCL cases. Although miR-222 was overexpressed in ¼ of the cases, it showed high speficity (98%) and positive predictive value (83%), Area Under the Curve= 0.87774, when EBV+ when compared to EBV negative cases. Summary /Conclusion The merit of the present study is to propose a microRNA signature for a recently described disease and to highlight miR-222 as a possible biomarker and therapeutic target for EBV+DLBCLe. The main routes deregulated are NF-KappaB and PI3K-AKT pathway, being PTEN a target of the overexpressed miR-222. Thus, the findings suggest that antagomiRs for miR-222,that are being tested in some types of cancer, could be also used as adjuvant therapy to R-CHOP in EBV+DLBCL. (Supported by FAPESP 2010/17668-6). Disclosures: No relevant conflicts of interest to declare.

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28

Marshall, Fiona H. "Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling." Trends in Biochemical Sciences 41, no. 12 (December 2016): 985–86. http://dx.doi.org/10.1016/j.tibs.2016.10.006.

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29

WEBB, DONALD W., and MARK A. METZ. "A revision of the New World genus Penniverpa Irwin and Lyneborg (Diptera: Therevidae: Therevinae)." Zootaxa 1720, no. 1 (March 5, 2008): 1. http://dx.doi.org/10.11646/zootaxa.1720.1.1.

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The genus Penniverpa Irwin and Lyneborg is revised and includes 13 species from the New World. Six of these: Penniverpa bradleyi Webb, n. sp., P. chersonesa Webb, n. sp., P. epidema Webb n. sp., P. evani Webb, n. sp., P. insular Webb, n. sp., P. megaplax Webb, n. sp., P. multisetosa Webb, n. sp., and P. unispinosa Webb, n. sp. are new to science. Penniverpa longipes (Loew) is placed in the genus Insulatitan (n. comb.) and becomes the senior synonym of Insulatitan romaynae Metz & Irwin, n. syn. and Psilocephala gracilis Kröber is placed in the genus Penniverpa (n. comb.) and is the senior synonym of Penniverpa brunnipennis (Kröber), n. syn. Penniverpa alvadusta Irwin & Webb is found to be a junior synonym of P. alvatra Irwin & Webb, n. syn. and Penniverpa lyneborgi Irwin & Webb and P. stigmaticalis (Schiner) are found to be junior synonyms of Penniverpa dives (Schiner), n. syn. Each species is described or redescribed with illustrations of their genitalia, a key to their identification, and a map of their distribution.

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Lamrabet, Abdesslam, Abdelmajid Maghnouj, and Jaouad Tajmouati. "GEANT4 modeling of the international MEGAPIE experiment." Advanced Studies in Theoretical Physics 11 (2017): 567–75. http://dx.doi.org/10.12988/astp.2017.7732.

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Thiollière, Nicolas, Luca Zanini, Jean-Christophe David, Jost Eikenberg, Arnaud Guertin, Alexander Yu Konobeyev, Sébastien Lemaire, and Stefano Panebianco. "Gas Production in the MEGAPIE Spallation Target." Nuclear Science and Engineering 169, no. 2 (October 2011): 178–87. http://dx.doi.org/10.13182/nse10-53.

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Thomsen, K. "VIMOS, near-target beam diagnostics for MEGAPIE." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 575, no. 3 (June 2007): 347–52. http://dx.doi.org/10.1016/j.nima.2007.03.011.

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Dai, Y., M. Wohlmuther, V. Boutellier, S. Hahl, A. Lagotzki, H. Leu, H. P. Linder, et al. "Non-destructive testing of the MEGAPIE target." Journal of Nuclear Materials 468 (January 2016): 221–27. http://dx.doi.org/10.1016/j.jnucmat.2015.08.026.

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Chen, Haiyan, and Xu Cheng. "ICONE15-10851 ATHLET-MF ANALYSIS OF MEGAPIE HEAT REMOVAL SYSTEM." Proceedings of the International Conference on Nuclear Engineering (ICONE) 2007.15 (2007): _ICONE1510. http://dx.doi.org/10.1299/jsmeicone.2007.15._icone1510_434.

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Muntión, Sandra, Post Doc Fellowship, Teresa Ramos, Bruno Paiva, Beatriz Roson, Maria Eugenia Sarasquete, Maria Diez-Campelo, et al. "Bone Marrow Mesenchymal Stem Cell (BM-MSC) Release Microvesicles/Exosomes That Incorporate Into Hematopoietic Cells From MDS Patients and May Modify Their Behaviour." Blood 122, no. 21 (November 15, 2013): 863. http://dx.doi.org/10.1182/blood.v122.21.863.863.

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Abstract A new mechanism of intercellular communication has been proposed consisting in the secretion of exosomes/ microvesicles (MVs). Such mechanism has been shown to modify the functional properties of recipient cells by the transfer of proteins, mRNA, or micro-RNAs. The hypothesis of the present work was that MSC from MDS patients could differentially modify the HPC properties throughout the shedding of MVs when compared with those from controls due to their different content. Material and methods: MVs were isolated from MSC from bone marrow (BM) samples 18 patients diagnosed with ‘de novo’ and untreated low risk MDS and from MSC from 12 healthy BM. BM-MSC at third passage were cultured in DMEM deprived of FCS, and supernatants were collected after 6 or 24 hours. MVs purification was performed in the majority of the experiments (16 MDS/ 9 Controls) using the ExoQuick-TC exosome precipitation solution (ExoQuick; System Biosiences). To confirm the isolation of MVs by exosome precipitation solution, in some cases (2 MDS/3 Controls) the MVs were obtained by ultracentrifugation; MVs identification was done by transmission electron microscopy (TEM) as well as by flow cytometry (FC). To evaluate if the micro-RNA content into MSC-MVs from patients and controls was different, expression analysis of miRNAs was done using Megaplex™ RT Primers pool (Applied Biosystems) and 384-well microfluidic cards (TaqMan® MicroRNA Array A) were loaded with retro-transcription product and PCR runs were performed on a 7900HT Fast Real-time PCR system (eight MVs from MDS and 4 from HD).To demonstrate the incorporation of MVs from MSC into human hematopoietic progenitors (HPC: CD34+ cells obtained by immunomagnetic selection) HPC were co-cultured with MVs from MSC. Incorporation of Vybrant Dil-labelled MVs into HPC was evaluated at 1, 3, 6, and 24 h. by FC. To detect the incorporation of MVs by confocal microscopy (CM) an intracellular primary Ab for CD90 (Santa Cruz, Biotechnology) was used as MVs marker and anti-CD45 to detect HPC. A Zeiss LSM 510 CM connected to a digital camera (Leica DC 100) were used to obtain confocal images. Apoptotic rate of CD34+ cells that had the MVs-MSC from MDS and controls were evaluated by FC by using APC H7 Annexin V DY634 (Immunostep) and 7AAD (BD Biosciences). Results: More than 95% of MVs isolated by ExoKit system from supernatants of cultured MSC from 6 HD and 6 MDS patients showed scatter intensities lower than of 6µm beads. We observed, in all cases, the same FC pattern. Also, MVs/exosomes isolated by ultracentrifugation (3 MDS/ 5 HD) showed the same FC pattern. MVs from MDS and controls isolated by ultracentrifugation were identified by TEM (fig1). When co-cultures of CD34+ HPC and MVs were studied in both HD and MDS, MVs were incorporated into HPC in all cases (fig2). When the content of miRNAS in the MVs from MDS and HD were compared significant differences were observed between both groups. Twenty-one out of 384 evaluated miRNAs were over-expressed in the MVs from patients compared with the controls. To confirm these results, the expression of miR10a and miR-132 was analyzed by RT-PCR. In both cases their expression was significantly increased in MVs from patients. Recently, it has been suggested that the cargo of these structures are bioactive molecules, therefore we explored the possibility that MVs could modify the behavior of the target cell. For this purpose we searched in which pathways the overexpressed miRNAs could be involved and apoptosis was among them. Since it is considered a very important process in MDS pathophysiology we compared apoptosis by FC, after co-culturing CD34+ cells with MVs from MSC of MDS and HD. Interestingly, preliminary results show that the MVs from MDS protected better from apoptosis CD34+ cells than MVs obtained from controls. In summary, in the present study we show that BM-MSC produce MVs/exosomes with different microRNAs content according to their origin, MDS or HD. These structures can be incorporated into HPC and can modify their properties. Funding: Instituto de Salud Carlos III. PI12/01775. Junta de Castilla y León.GRS 873/A/13. Portuguese FST Grant. SFRH/BD/86451/2012 Disclosures: Diez-Campelo: Celgene: Honoraria, Research Funding; Novartis: Honoraria, Research Funding. San Miguel:Jansen, Celgene, Onyx, Novartis, Millenium: Membership on an entity’s Board of Directors or advisory committees. del Cañizo:Celgene: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Jansen-Cilag: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Arry: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Novartis: Membership on an entity’s Board of Directors or advisory committees, Research Funding.

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36

DALZIEL, M. "Megapoles Project: working on behalf of socially disadvantaged groups." Journal of Epidemiology & Community Health 55, no. 3 (March 1, 2001): 154–55. http://dx.doi.org/10.1136/jech.55.3.154.

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37

Auger, T., L. Aphecetche, A. Cadiou, Y. Dai, H. Glasbrenner, F. Gröschel, and T. Kirchner. "MEGAPIE target design and LiSoR experiment — Status report." Journal de Physique IV (Proceedings) 12, no. 8 (September 2002): 27–43. http://dx.doi.org/10.1051/jp4:20020320.

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38

Konobeyev, A. Yu, U. Fischer, and L. Zanini. "Analysis of nuclide production in the MEGAPIE target." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 605, no. 3 (July 2009): 224–32. http://dx.doi.org/10.1016/j.nima.2009.03.218.

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39

Zanini, L., S. Dementjev, F. Gröschel, W. Leung, R. Milenkovic, K. Thomsen, W. Wagner, et al. "Experience from the post-test analysis of MEGAPIE." Journal of Nuclear Materials 415, no. 3 (August 2011): 367–77. http://dx.doi.org/10.1016/j.jnucmat.2011.04.037.

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40

Mikityuk, Konstantin, Paul Coddington, and Friedrich Gröschel. "Analysis of radioactivity releases in the MEGAPIE reference accident." Nuclear Engineering and Design 238, no. 7 (July 2008): 1838–44. http://dx.doi.org/10.1016/j.nucengdes.2007.12.004.

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41

Zucchini, A., P. Agostini, and E. Baicchi. "Lead–bismuth eutectic recrystallization studies for the Megapie target." Journal of Nuclear Materials 336, no. 2-3 (February 2005): 291–98. http://dx.doi.org/10.1016/j.jnucmat.2004.10.003.

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42

Dalziel, M. "Project megapoles: promoting better health for socially disadvantaged groups across Europe." European Journal of Public Health 10, no. 3 (September 1, 2000): 228–30. http://dx.doi.org/10.1093/eurpub/10.3.228.

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43

Bubelis, Evaldas, Paul Coddington, and Konstantin Mikityuk. "Verification of the TRACE code against the MEGAPIE transient data." Annals of Nuclear Energy 35, no. 7 (July 2008): 1284–95. http://dx.doi.org/10.1016/j.anucene.2007.12.006.

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44

Link, Andreas, and Christa E. Müller. "G-Protein-Coupled Receptors: Sustained Signaling via Intracellular Megaplexes and Pathway-Specific Drugs." Angewandte Chemie International Edition 55, no. 52 (October 24, 2016): 15962–64. http://dx.doi.org/10.1002/anie.201609015.

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45

Smith, B. L., W. Leung, and A. Zucchini. "Coupled fluid/structure analyses of the MEGAPIE spallation source target during transients." Nuclear Engineering and Design 237, no. 15-17 (September 2007): 1656–67. http://dx.doi.org/10.1016/j.nucengdes.2007.02.020.

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46

Michel-Sendis, F., S. Chabod, A. Letourneau, S. Panebianco, and L. Zanini. "Neutronic performance of the MEGAPIE spallation target under high power proton beam." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 268, no. 13 (July 2010): 2257–71. http://dx.doi.org/10.1016/j.nimb.2010.03.024.

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47

Bauer, G. S., M. Salvatores, and G. Heusener. "MEGAPIE, a 1 MW pilot experiment for a liquid metal spallation target." Journal of Nuclear Materials 296, no. 1-3 (July 2001): 17–33. http://dx.doi.org/10.1016/s0022-3115(01)00561-x.

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48

Mooney, P. E., and O. L. Krivanek. "Image-coupling methods in CCD cameras for Electron Microscopy." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 406–7. http://dx.doi.org/10.1017/s0424820100169766.

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It is well established that the charge-coupled device (CCD) is the detector of choice in imaging applications requiring sensitivity, dynamic range, linearity and low geometric distortion. It has also been shown that in the electron microscope, indirect coupling of the image by a scintillator and transfer optic is required to prevent damage to the CCD and to allow for sufficient dynamic range. The question then follows how best to design the coupling to achieve the image quality required for digital imaging in electron microscopy.We have characterized slow-scan CCD cameras with three representative optical couplings (Figure 1):1:1 fiber-optically coupled camera with a large-pixel CCD (TK1024) and both single-crystal and powder scintillators for 100-400 kV applications requiring good sensitivity,1:1 tandem lens-coupled camera with a large-pixel CCD (TK1024) and a powder scintillator mounted on an ultra-thin Al foil for high voltage applications, and3:1 reduction macro lens-coupled camera with a fast, small-pixel CCD (Kodak MegaPlus) and thin scintillator mounted on a glass prism for applications requiring fast read-out, but not high sensitivity.In this abstract we compare the three coupling methods to each other, and also to a TV-rate fiber-optically coupled CCD camera.

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Dementjev, S., F. Groeschel, and N. Jekabsons. "MEGAPIE project, experience of electromagnetic pumps operation in the Swiss Spallation Neutron Source." Magnetohydrodynamics 44, no. 3 (2008): 279–88. http://dx.doi.org/10.22364/mhd.44.3.6.

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DURY, Trevor V. "CFD Design Support at PSI for the International MEGAPIE Liquid-Metal Spallation Target." Journal of Nuclear Science and Technology 41, no. 3 (March 2004): 285–95. http://dx.doi.org/10.1080/18811248.2004.9715487.

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Journal articles on the topic 'Megaplex'

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