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Dissertations / Theses on the topic 'Meiosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Canales, C. "Characterisation of extra sporogenous cells (ESP) : an avbidopsis gene required for another development." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365861.

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2

Phizicky, David V. (David Vincent). "Mechanisms preventing DNA replication between Meiosis I and Meiosis II." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117786.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged student-submitted from PDF version of thesis.<br>Includes bibliographical references.<br>The vast majority of multicellular organisms reproduce using sexual reproduction, which requires the production of haploid gametes. These gametes are produced by meiosis, a specialized cell division during which one round of DNA replication is followed by two roun
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3

Marcet, Ortega Marina. "Surveillance mechanisms in mammalian meiosis." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/387429.

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Per tal de protegir les cèl·lules germinals de sofrir inestabilitat genòmica, diversos mecanismes de control s’encarreguen de que la progressió de la meiosis sigui correcte. En mamífers, els espermatòcits que presenten defectes de recombinació o de la formació de la vesícula sexual pateixen un bloqueig a l’estadi de paquitè. Estudis previs del nostre laboratori descriuen que la via complex MRE11-ATM-CHK2 activa l’arrest dependent de recombinació en presència de trencaments de doble cadena (DSBs) no reparats. L’objectiu d’aquest treball ha estat identificar si els membres de la família p53, els
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4

Fabig, Gunar. "Dynamic and ultrastructural characterization of chromosome segregation in C. elegans male meiosis." Technische Universität Dresden, 2018. https://tud.qucosa.de/id/qucosa%3A32727.

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The production of germ cells is an essential process in all sexually reproducing eukaryotes. During male meiosis, four haploid sperm cells are formed from one primary spermatocyte, thereby undergoing two consecutive cell divisions after only one round of chromosome duplication. This process was studied in the nematode Caenorhabditis elegans, as this model organism offers a number of experimental advantages to simultaneously analyze spindle dynamics and ultrastructure. The worm is easy to cultivate, completely sequenced and numerous mutants are available, the worm is small and thus ideal for li
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5

Connor, Colette. "Investigating the role of Cdc14 in the regulation of the meiosis I to meiosis II transition." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/21086.

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Meiosis is a specialized cell division that produces haploid gametes from a diploid progenitor cell. It consists of one round of DNA replication followed by two consecutive rounds of chromosome segregation. Homologous chromosomes segregate in meiosis I and sister chromatids segregate in meiosis II. Failure to correctly regulate meiosis can result in aneuploidy, where daughter cells inherit an incorrect number of chromosomes. Aneuploidy is usually poorly tolerated in eukaryotes, and is associated with infertility, miscarriages and birth defects. At the meiosis I to meiosis II transition, DNA re
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6

Igea, Fernández Ana. "CPEB4 replaces CPEB1 to complete meiosis." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/22687.

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In vertebrate oocytes, meiotic progression is driven by the sequential translational activation of maternal messenger RNAs stored in the cytoplasm. This activation is mainly induced by the cytoplasmic elongation of their poly(A) tails, which is mediated by the cytoplasmic polyadenylation element (CPE) present in their 3’ untranslated regions (3´ UTRs). Sequential, phase-specific translation of these maternal mRNAs is required to complete the two meiotic divisions. Although the earlier polyadenylation events in prophase I and metaphase I are driven by the CPE-binding protein 1 (CPEB1), 90% of t
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7

Çetin, Bülent. "Chromosome segregation in mitosis and meiosis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669990.

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8

Rattani, Ahmed Anwer Ali. "Regulation of anaphase in mammalian meiosis." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639733.

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Missegregation of chromosomes during meiosis leads to formation of aneuploid eggs. Estimates suggest that in humans, about 10-30% of fertilised eggs and one-third of all miscarriages are aneuploid. Accurate chromosome segregation depends on the coordination between stepwise cohesion resolution and attachments of homologous chromosomes through kinetochores to microtubules, emanating from opposite poles of the cell. The Spindle Assembly Checkpoint (SAC) monitors microtubule-kinetochore attachments and prevents resolution of cohesin complexes by inhibiting the ubiquitin ligase APC/Ccdc2o until al
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9

Winters, Tristan. "The role of STAG3 in mammalian meiosis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-233399.

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The cohesin complex is essential for mitosis and meiosis. The specific meiotic roles of individual cohesin proteins are incompletely understood. We report in vivo functions of the only meiosis-specific STAG component of cohesin, STAG3. Newly generated STAG3-deficient mice of both sexes are sterile with meiotic arrest. In these mice, meiotic chromosome architecture is severely disrupted as no bona fide axial elements (AE) form and homologous chromosomes do not synapse. Axial element protein SYCP3 forms dot-like structures, many partially overlapping with centromeres. Asynapsis marker HORMAD1 is
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10

Fernandes, Joiselle Blanche. "Identification et caractérisation fonctionnelle de gènes contrôlant la fréquence de crossovers méiotiques." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS303/document.

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Les crossing-overs (CO) sont issus d’échange réciproque de matériel génétique entre les chromosomes homologues. Les COs produisent de la diversité génétique et sont essentiels chez la plupart des eucaryotes, pour la distribution équilibrée des chromosomes lors de la méiose. Malgré leur importance, et un large excès de précurseurs moléculaires, le nombre de CO est très limité dans la grande majorité des espèces (Typiquement 1 à 4 par paire de chromosomes). Cela suggère que les COs sont étroitement régulés, mais les mécanismes sous-jacents sont mal connus. Pour identifier les gènes qui limitent
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11

Pasternak, Michał. "RNAi screen for meiotic genes in mammals reveals BTG4 as a novel regulator of meiosis." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/283984.

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12

Widger, Alexander David. "Ablating ATR in mouse meiosis and its consequences for synapsis, recombination and meiotic surveillance mechanisms." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10043772/.

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Meiosis is a fundamental part in the life cycle of sexual species. It denotes a specialised cell division that halves chromosome numbers to generate haploid gametes for reproduction. Cells unable to competently progress through meiotic prophase activate cell surveillance mechanisms causing their elimination. Given the importance of DNA damage kinases like ATR in facilitating mitotic cell surveillance mechanisms, I characterized Atr-deficient spermatocytes to determine the importance of ATR for mammalian meiosis. I found that ATR ensures efficient chromosome synapsis, and that that is partially
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13

Alemany, Schmidt Alexandra. "Bases moleculares de la meiosis en mamíferos." Doctoral thesis, Universitat de les Illes Balears, 2017. http://hdl.handle.net/10803/458994.

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- Introducció: La meiosi és un tipus de divisió cel·lular íntimament lligat a la gametogènesi en eucariotes superiors, la finalitat és la reducció del nombre cromosòmic de diploide a haploide (és a dir, de 2n a n) en el nucli dels gàmetes. En la present tesi s'han analitzat els processos de sinapsi i recombinació en tres espècies de mamífers: humans, moixos i cans. - Contingut de la investigació: Per a l’anàlisi dels processos de sinapsi i recombinació en tres espècies de mamífers (humans, moixos i cans) s'ha utilitzat la tècnica d’immunocitogenètica, la qual ha permès determinar els va
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14

Bhuiyan, Hasanuzzaman. "Chromosome synapsis and recombination in yeast meiosis /." Stockholm : Institutionen för molekylärbiologi och funktionsgenomik, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-225.

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15

Hunter, Neil. "The role of mismatch repair in meiosis." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337599.

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16

McGuinness, Barry E. "Chromosome Segregation during Mammalian Mitosis and Meiosis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490111.

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The spindle assembly checkpoint (SAC) functions to prevent anaphase onset until all chromosomes are correctly bi-oriented on the mitotic spindle and aligned at the metaphase plate. Cohesion between sister chromatids is essential for this biorientation. In animal cells, most cohesin is removed from chromosome arms during prophase and prometaphase. Cohesin at centromeres is refractory to removal at this stage and persists until metaphase, whereupon its Sccl subunit is cleaved by separase, which is thought to trigger anaphase. What protects centromeric cohesin from the prophase pathway? 1 show th
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17

Ye, Jinpei. "Signalling pathways controlling meiosis in porcine oocytes." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273192.

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18

Chang, Heng-Yu. "The progression of meiosis in mouse oocytes." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427346.

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19

Paterson, Lesley Ann. "Reinitiation of meiosis in polychaete (annelida) oocytes." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14564.

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This thesis presents ultrastructural and biochemical information on meiotic reinitiation during oocyte maturation in the polychaetes, Arenicola marina, A. defodiens and Nereis virens. The ultrastructural changes during meiotic maturation was characterised in the oocytes of Arenicola marina and Nereis virens using transmission electron microscopy in addition to germinal vesicle breakdown, release of the prophase I block was signified by major cortical changes in both species. The ultrastructure of fertilization in A. marina was independent of whether the oocytes were matured in vivo and spawned
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20

Savelkoul, Elizabeth Jennings. "Molecular evolution of meiosis genes in fungi." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/6635.

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Meiosis as a general process is prevalent across the eukaryotes, as are the orthologs of many genes encoding proteins known to function in meiosis. However, many organisms have experienced derived losses of otherwise well-conserved meiosis genes without losing meiosis and sexual reproduction. Although this general conservation of meiosis genes and precedent for derived meiosis gene losses has been previously established, questions remain about the frequency of and evolutionary forces contributing to these trends. This work sought (i) to characterize the phylogenetic distribution of 15 meiosis
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21

Martínez, Marchal Ana. "Regulation of the oocyte pool in mammals." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667797.

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Durant la oogènesi dels mamífers, les oogònies proliferen forman els anomenats cists. Les oogònies entren en meiosis progressant en la profase I i els cists es trenquen al mateix temps que es produeix una mort massiva perinatal dels oòcits. En la profase I, s’indueixen trencaments de doble cadena (DSBs) per tot el genoma, que son reparats per recombinació homòloga per a promoure la sinapsi dels cromosomes homòlegs. Existeixen diferents mecanismes que s’activen en resposta a errors en aquests processos i que aturen el cicle cel·lular i produeixen l’apoptosi de les cèl·lules danyades. La respost
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22

Ernst, Christina. "Transcriptional and developmental consequences of aneuploidy during male meiosis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278212.

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Eukaryotes have developed stringent regulatory mechanisms that control cell division and ensure proper chromosome segregation. Maintaining genome integrity is especially important during meiosis, the specialised cell division programme in the germline that generates haploid gametes. As these cells transmit genetic information to the next generation, the consequences of meiotic errors are not restricted to an organismal level, but can directly impact the fitness of the offspring. Mammals display a high degree of sexual dimorphism in meiosis with regard to the stringency of regulatory mechanisms
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23

Finsterbusch, Friederike. "Analysis of gene expression data from Massive Parallel Sequencing identifies so far uncharacterised regulators for meiosis with one candidate being fundamental for prophase I in male and female meiosis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-202144.

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Meiosis is a specialized division of germ cells in sexually reproducing organisms, which is a fundamental process with key implications for evolution and biodiversity. In two consecutive rounds of cell division, meiosis I and meiosis II, a normal, diploid set of chromosome is halved. From diploid mother cells haploid gametes are generated to create genetic individual cells. This genetic uniqueness is obtained during prophase of meiosis I by essential meiotic processes in meiotic recombination, as double strand break (DSB) formation and repair, formation of crossovers (CO) and holiday junctions
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24

Oelschlägel, Tobias. "Meiosis-specific Regulation of the Anaphase-Promoting Complex." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1143717017741-21454.

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Meiosis is a specialized cell cycle, which generates haploid gametes from diploid parental cells. During meiosis one round of cohesion establishment during premeiotic DNA replication mediates two rounds of chromosome segregation. During meiosis I homologous chromosomes separate, whereas sister chromatids segregate during the second meiotic division without an intervening round of DNA replication. Both rounds of chromosome segregation are triggered by an ubiquitin ligase called the Anaphase-Promoting Complex or Cyclosome (APC/C). APC/C-dependent destruction of securin/Pds1 is required to activa
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25

Percy, Melanie Joan. "Meiosis-associated proteins in male Stauroderus scalaris (Orthoptera)." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335446.

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26

Riaz, Abida. "Cyclin B in fission yeast mitosis and meiosis." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286160.

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27

Tiang, Choon Lin. "The role of SYN1 in early Arabidopsis meiosis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1341/.

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SYN1 is a meiosis-specific Arabidopsis homologue of yeast REC8. REC8 is an important component of the meiotic cohesion complex which maintains cohesion between sister chromatids. Cytological analysis of syn1\(^{-/-}\) has shown chromosome fragmentation at metaphase I. To determine the basis of chromosome fragmentation in the syn1\(^{-/-}\), three double mutants were constructed. I have demonstrated that chromosome fragmentation in syn1 is AtSPO11-1-dependent. Moreover, I have also shown that SYN1 has a role in DSB repair by analysing Atdmc1\(^{-/-}\)/syn1\(^{-/-}\) meiocytes. To investigate th
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28

Carlile, Thomas M. (Thomas Marshal) Jr. "Cyclin-Dependent Kinase regulation and function during meiosis." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57557.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student submitted PDF version of thesis.<br>Includes bibliographical references.<br>Meiosis is the process by which haploid gametes are produced from a diploid progenitor cell. Accurate completion of the meiotic divisions requires a variety of modifications to the mitotic chromosome segregation machinery, which allow the reductional meiotic chromosom
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29

Hochwagen, Andreas. "Analysis of cell cycle surveillance mechanisms in meiosis." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/33214.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Vita.<br>Includes bibliographical references.<br>Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple DNA repair and microt
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30

Barlow, Andrew Leslie. "Immuno and molecular cytogenetic analysis of human meiosis." Thesis, University of Birmingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.668171.

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31

Tibbles, Katherine L. "Regulation of Clb1 during meiosis in Saccharomyces cerevisiae." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/60444/.

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Meiosis is a specialised form of cell division in which diploid cells divide to form four non-identical spores containing half the genetic complement of the parent. During this cell division program, much of the usual machinery regulating cell division is put to alternate use to allow the cells to undergo an extra round of division without an intervening phase of DNA synthesis. In particular, the end of the first division, meiosis I, must be regulated differently than the end of the mitotic division. We used the model organism Saccharomyces cerevisiae to determine some of these differences in
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32

Oelschlägel, Tobias. "Meiosis-specific Regulation of the Anaphase-Promoting Complex." Doctoral thesis, Technische Universität Dresden, 2005. https://tud.qucosa.de/id/qucosa%3A24682.

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Meiosis is a specialized cell cycle, which generates haploid gametes from diploid parental cells. During meiosis one round of cohesion establishment during premeiotic DNA replication mediates two rounds of chromosome segregation. During meiosis I homologous chromosomes separate, whereas sister chromatids segregate during the second meiotic division without an intervening round of DNA replication. Both rounds of chromosome segregation are triggered by an ubiquitin ligase called the Anaphase-Promoting Complex or Cyclosome (APC/C). APC/C-dependent destruction of securin/Pds1 is required to activa
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33

Joshi, Neeraj. "CONTROL OF INTERACTIONS BETWEEN HOMOLOGOUS CHROMOSOMES DURING MEIOSIS." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1403797339.

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34

Labrador, Gonzalez Leticia. "Roles of SPD-3 during C. elegans meiosis." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9563.

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Correct chromosome segregation during meiosis requires that the paternal and maternal copies of each chromosome, known as homologues, recognise and pair with one another before they can undergo meiotic recombination. Defects in this process lead to sterility and the formation of aneuploid gametes, which is the leading cause of birth defects in humans. In this study the process of homologue pairing during meiosis has been investigated in C. elegans, an organism especially well suited for meiotic studies. During a genetic screen for meiotic mutants, several mutants with defects in meiotic chromo
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35

Beekman, Danielle Jeanine. "The evolution and expression of Drosophila meiosis genes." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1545.

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Drosophila melanogaster is unique amongst model organisms in that males utilize achiasmatic meiosis, where formation of the synaptonemal complex (SC) and recombination are absent. Most organisms require the SC and chiasmata for the successful completion of meiosis and production of viable gametes, making D. melanogaster an ideal system for the study of meiotic variation. The goal of my research was to examine in detail the origin and evolution of male achiasmatic meiosis in Diptera. This was done in three parts: 1) assessing the presence and absence of meiosis genes across dipteran species, 2)
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36

Pyatnitskaya, Alexandra. "Interplay between meiotic crossing-overs and chromosome architecture : role of the meiosis specific complex Zip2-Zip4-Spo16." Electronic Thesis or Diss., Université Paris sciences et lettres, 2021. http://www.theses.fr/2021UPSLS061.

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La méiose est une étape essentielle de la reproduction chez tous les organismes sexués. En effet, celle-ci permet l’obtention de quatre gamètes haploïdes à partir d’une seule cellule diploïde grâce à la réalisation deux divisions successives suivant une seule étape de réplication. Un des éléments essentiels permettant une bonne ségrégation en première division méiotique est la création d’un échange physique entre les chromosomes homologues parentaux. Ce lien physique, plus communément appelé crossing-over (CO), est produit par un mécanisme de recombinaison entre les chromosomes homologues au c
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37

Frenk, Stephen. "Investigating the role of transcriptomic changes in meiosis and ageing." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709201.

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38

Gonzalo, Adrian. "Voies de formation des crossovers méiotiques chez une espèce allopolyploïde, le colza (Brassica napus)." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS352.

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La recombinaison méiotique est au cœur de l'hérédité Mendélienne, de l'évolution et de l'amélioration des plantes, car elle assure, grâce aux crossovers, une transmission fidèle des chromosomes et le brassage de l’information génétique au fil des générations. Deux voies de formation des crossovers coexistent chez les plantes. La voie principale (voie I) dépend de la protéine MSH4 (et de quelques autres). La voie secondaire ne produit que quelques crossovers (dits de voie II) au cours de la méiose d’une plante de type sauvage ; ils sont indépendants de MSH4 et leur nombre est limité par des pro
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Wolf, Peter G. [Verfasser], and Olaf [Akademischer Betreuer] Stemmann. "Meiosis made simple : Mechanisms of meiotic chromosome dynamics elucidated in somatic cells / Peter G. Wolf ; Betreuer: Olaf Stemmann." Bayreuth : Universität Bayreuth, 2017. http://d-nb.info/113220092X/34.

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40

González, Pérez Laura. "Role of the atypical CDK activator RINGO beyond meiosis." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668658.

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The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated by non-cyclin proteins. RINGO is an atypical CDK activator which regulates the meiotic maturation of Xenopus oocytes and has been recently described as essential for meiotic prophase in mouse. As an activator of CDKs, RINGO has a potential role in cell cycle regulation. CDK regulation by RINGO has been extensively studied in vitro. However, the implication of RINGO in particu
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41

Srayko, Martin Anthony. "The role of mei-2 in Caenorhabditis elegans meiosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/NQ54812.pdf.

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42

Colas, Isabelle. "A study of the mechanisms of meiosis in wheat." Thesis, University of East Anglia, 2008. https://ueaeprints.uea.ac.uk/10625/.

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Breeding programs have the objectives to develop more productive and more stable varieties. Hybridization and selection are frequently employed in plant breeding and the success of introgression of special traits such as disease resistance relies on genetic recombination between the host and alien chromosomes. During meiosis, homologous chromosomes recognized each other, align and pair which ensure their recombination and correct segregation at metaphase. This process controls aberrant chromosome number within the gametes, and ensures that genes are shuffled by recombination. 70% of flowering
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43

Lightfoot, James William. "The roles of SCC-2 during C. elegans meiosis." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554218.

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Cohesin mediates sister chromatid cohesion (SCC), and its regulated association with chromatin is required to promote faithful chromosome segregation during mitosis and meiosis, as well as for the efficient repair of DNA double strand breaks (DSBs). In the mitotic cell cycle loading of cohesin requires a conserved complex containing the Scc2INipbl protein, which has also been proposed to promote binding of the cohesin-related complexes condensin and SMC-5/6. However, little is known about the factors that promote loading of cohesin and related SMC (structural maintenance of chromosomes) comple
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44

Seres, Karmen Bianka. "Characterisation of a novel spindle domain in mammalian meiosis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288373.

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The organisation of microtubule networks into a bipolar spindle is essential for reliable chromosome segregation during cell division. A pair of centrioles surrounded by pericentriolar material (PCM), define the canonical centrosome that acts as the main microtubule organising centre (MTOC) during mitosis. In mammalian meiosis, centrioles are eliminated early on during oogenesis. Despite the absence of centrosomes, a large number of centrosomal proteins are highly expressed in mouse oocytes. Here, I characterise the localisation and function of centrosomal proteins at a previously undescribed
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45

Newcombe, Sonya. "The role of the Smc5/6 complex in meiosis." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/69253/.

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46

Johnson, Dominic. "Investigating double-strand break formation and repair in meiosis." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68428/.

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47

Hua, Hui. "Regulation of DNA replication during meiosis in fission yeast." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5d4d66ab-5441-4e96-adb1-28f4b51a975b.

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The interval between meiotic nuclear divisions can be regarded as a modified mitotic cell cycle where DNA replication is blocked. Mechanisms regulating this critical aspect of meiosis that allows haploid cells to be generated from a diploid progenitor were investigated in this project. Licensing is restricted after meiosis I due to down-regulation of Cdc18 and Cdt1. Late meiotic expression of Cdc18 and Cdt1, which load the MCM helicase onto replication origins, can lead to partial DNA replication after meiosis I. This implies that block to initiation via licensing forms an important component
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48

Cherry, Sheila M. "ELUCIDATION OF FACTORS IMPACTING HOMOLOGOUS RECOMBINATION IN MAMMALIAN MEIOSIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1154979383.

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49

Catlett, Michael G. "Fission yeast MCMs, meiosis, and the recombination protein Rdh54 /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3090446.

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50

Cunliffe, Lesley. "Transcription during meiosis in the fission yeast Schizosaccharomyces pombe." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/30900/.

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The meiotic cell cycle is the process by which diploid organisms divide to produce haploid gametes and consists of one round of DNA replication followed by two successive nuclear divisions. In the fission yeast, Schizosaccharomyces pombe, meiosis is initiated from G1 phase and involves a complex series of cellular events that lead to the production of four haploid ascospores. The periodic regulation of gene expression is an important mechanism of control of both mitotic- and meiotic-cell-cycle progression. During the mitotic cell cycle of fission yeast a number of genes, including cdc22+, cdc1
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