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Journal articles on the topic 'MEK COX-2 PGE2'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Maeda, Yuma, Fumiko Sekiguchi, Rumi Yamanaka, et al. "Mechanisms for proteinase-activated receptor 1-triggered prostaglandin E2 generation in mouse osteoblastic MC3T3-E1 cells." Biological Chemistry 396, no. 2 (2015): 153–62. http://dx.doi.org/10.1515/hsz-2014-0148.

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Abstract We analyzed signaling mechanisms for prostaglandin E2 (PGE2) production following activation of proteinase-activated receptor-1 (PAR1), a thrombin receptor, in preosteoblastic MC3T3-E1 cells. PAR1 stimulation caused PGE2 release, an effect suppressed by inhibitors of COX-1, COX-2, iPLA2, cPLA2, MAP kinases (MAPKs), Src, EGF receptor (EGFR) tyrosine kinase (EGFR-TK) and matrix metalloproteinase (MMP), but not by an intracellular Ca2+ chelator or inhibitors of PI3 kinase, protein kinase C (PKC) and NF-κB. PAR1 activation induced phosphorylation of MAPKs and upregulation of COX-2. The ph

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2

Rossen, John W. A., Janneke Bouma, Rolien H. C. Raatgeep, Hans A. Büller, and Alexandra W. C. Einerhand. "Inhibition of Cyclooxygenase Activity Reduces Rotavirus Infection at a Postbinding Step." Journal of Virology 78, no. 18 (2004): 9721–30. http://dx.doi.org/10.1128/jvi.78.18.9721-9730.2004.

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ABSTRACT Elevated levels of prostaglandins (PGs), products of cyclooxygenases (COXs), are found in the plasma and stool of rotavirus-infected children. We sought to determine the role of COXs, PGs, and the signal transduction pathways involved in rotavirus infection to elucidate possible new targets for antiviral therapy. Human intestinal Caco-2 cells were infected with human rotavirus Wa or simian rotavirus SA-11. COX-2 mRNA expression and secreted PGE2 levels were determined at different time points postinfection, and the effect of COX inhibitors on rotavirus infection was studied by an immu

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3

Shinoki, Kei, Taku Tsukui, Yoko Shinji, et al. "bFGF stimulates VEGF production through MEK-, PI-3 kinase- and COX-2-PGE2-dependent pathway in gastric fibroblasts." Gastroenterology 124, no. 4 (2003): A274. http://dx.doi.org/10.1016/s0016-5085(03)81373-2.

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4

das Neves, Raquel Nascimento, Aparna Gorthi, Alexander James Roy Bishop, and Alfeu Zanotto Filho. "Abstract P5-10-03: Mutant p53 and ERK1/2 MAPK cooperate with the production of TNBC inflammatory secretome." Cancer Research 82, no. 4_Supplement (2022): P5–10–03—P5–10–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-10-03.

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Abstract TP53 is the most frequently mutated gene in most types of human cancer, including breast cancer. The triple-negative breast cancer (TNBC) subtype in particular displays TP53 mutation in approximately 80% of patients. Unlike other breast cancer subtypes (e.g., ER/PR-positive or HER2-positive), TNBC patients currently lack an approved highly effective targeted therapy. Notably, most TNBC acquires TP53 mutations, which, in addition to the loss of canonical p53 functions, can result in gain-of-function, activating different cellular mechanisms involved in tumor phenotypes such as prolifer

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5

Liu, Fengjie, Tatiana Romantseva, Hana Golding, and Marina Zaitseva. "Activation of histone acetyltransferase p300 by MAPK pathway is required for optimal production of PGE2 in primary human monocytes activated with muramyl dipeptide adjuvant (MDP)." Journal of Immunology 198, no. 1_Supplement (2017): 124.15. http://dx.doi.org/10.4049/jimmunol.198.supp.124.15.

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Abstract Prostaglandin E2 (PGE2) is a proximal mediator of fever produced by human monocytes and macrophages activated by microbial pathogens and, in some cases, by adjuvants that contain analogues of microbial products. Here we studied the signaling pathway of PGE2 production in primary human monocytes activated with MDP, the minimal structure unit responsible for the adjuvant activity of peptidoglycans. MDP alone did not induce COX-2 mRNA expression and PGE2 protein production in monocytes. However, COX-2 mRNA and PGE2 were dramatically up-regulated when MDP was combined with T cell conditio

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6

Yang, Chien-Chung, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu, and Chuen-Mao Yang. "Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells." Mediators of Inflammation 2022 (April 19, 2022): 1–18. http://dx.doi.org/10.1155/2022/4600029.

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The inflammation of the airway and lung could be triggered by upregulation cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induced by various proinflammatory factors. COX-2 induction by thrombin has been shown to play a vital role in various inflammatory diseases. However, in human tracheal smooth muscle cells (HTSMCs), how thrombin enhanced the levels of COX-2/PGE2 is not completely characterized. Thus, in this study, the levels of COX-2 expression and PGE2 synthesis induced by thrombin were determined by Western blot, promoter-reporter assay, real-time PCR, and ELISA kit. The various sign

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Cao, Weibiao, Ling Cheng, Jose Behar, Piero Biancani та Karen M. Harnett. "IL-1β signaling in cat lower esophageal sphincter circular muscle". American Journal of Physiology-Gastrointestinal and Liver Physiology 291, № 4 (2006): G672—G680. http://dx.doi.org/10.1152/ajpgi.00110.2006.

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In a cat model of acute experimental esophagitis, resting in vivo lower esophageal sphincter (LES) pressure and in vitro tone are lower than in normal LES, and the LES circular smooth muscle layer contains elevated levels of IL-1β that decrease the LES tone of normal cats. We now examined the mechanisms of IL-1β-induced reduction in LES tone. IL-1β significantly reduced acetylcholine-induced Ca2+ release in Ca2+-free medium, and this effect was partially reversed by catalase, demonstrating a role of H2O2 in these changes. IL-1β significantly increased the production of H2O2, and the increase w

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8

Islam, Md Shafiqul, Hideki Ushio, Masatoshi Hori, and Hiroshi Ozaki. "Cycloartenyl Ferulate downregulates lipopolysaccharide stimulated iNOS mRNA via NF-kB suppression in RAW 264.7 macrophages." Asian Journal of Medical and Biological Research 2, no. 4 (2017): 523–31. http://dx.doi.org/10.3329/ajmbr.v2i4.30992.

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Cycloartenyl ferulate (CAF) is a major bioactive phytosteryl ferulate purified from rice bran ?- oryzanol. Previously we reported that CAF ameliorates DSS-induced colitis in mice. The present study was undertaken to investigate the effects of CAF on LPS (lipopolysaccharide) stimulated murine RAW 264.7 macrophages. Immunohistochemistry analysis demonstrated that LPS (10ng/mL) treatment exhibited nuclear translocation of NF-?B-p65 in RAW macrophages, which was markedly inhibited CAF (30?M). LPS (10ng/mL) stimulation for 1-4 hours significantly upregulated iNOS and COX-2 mRNA in RAW 264.7 macroph

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9

Souri, M. Sofyan, Sri Oktavia, and Ifora Ifora. "Potential anti-inflammatory effects of Psidium guajava L.: A review." Asian Journal of Pharmaceutical Research and Development 9, no. 2 (2021): 47–52. http://dx.doi.org/10.22270/ajprd.v9i2.941.

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Inﬂammation is a defence mechanism of a body against foreign substances. However, Inﬂammation also plays a key role in diseases such as diabetes, asthma, cardiovascular diseases, and cancer. Increasing scientiﬁc evidence has shown that fruits, vegetables, and legumes can have anti-inﬂammatory properties. This paper aims to provide recent studies on the anti-inflammatory properties of Psidium guajava L. A review was conducted on the studies of Psidium guajava L. anti-inflammatory properties performed during the past 10 years with the literature databases such as Pub Med, Science Direct, Google

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10

Lee, Kyung-Mi, Taejin Park, Min-Seon Kim, Jin-Soo Park, Won-Jae Chi та Seung-Young Kim. "Anti-inflammatory Activities of 7,8-Dihydroxy-4-Methylcoumarin Acetylation Products via NF-κB and MAPK Pathways in LPS-Stimulated RAW 264.7 Cells". Natural Product Communications 17, № 5 (2022): 1934578X2210868. http://dx.doi.org/10.1177/1934578x221086893.

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Coumarins are phenolic compounds that are characterized by fused benzene and α-pyrone rings. Among coumarin-based compounds, 7,8-dihydroxy-4-methylcoumarin (DHMC) has anti-inflammatory activities, but whether the level of this activity varies according to the degree of acetylation remains unknown. Therefore, we acetylated DHMC to yield monoacetylated 8-acetoxy-4-methylcoumarin (8AMC) and 7,8-diacetoxy-4-methylcoumarin (DAMC). We then compared the anti-inflammatory activities of DHMC with its acetylated derivatives and discovered a novel anti-inflammatory agent. We evaluated whether DHMC, 8AMC,

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11

Hoxha, M., V. Malaj, and B. Zappacosta. "AB0097 EFFECT OF CYTOCHROME P450 METABOLITES OF ARACHIDONIC ACID IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1179.2–1179. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4779.

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BackgroundArachidonic acid (AA) is a polyunsaturated fatty acid, released in inflammatory disease, such as rheumatoid arthritis (RA). Cyclooxygenase (COX) and lypooxygenase (LOX) pathways have received greater attention than cytochrome P450 (CYP) pathway of AA, which also plays a significant role in RA. AA is a substrate of CYP enzymes through two different pathways: the ω-hydroxylase, and epoxygenase pathways, respectively. The epoxygenase gives rise to epoxyeicosatrienoic acids (EETs) (5,6-EET, 8,9-EET, 11,12-EET, 14,15-EET), whereas ω- hydroxylase produces hydroxyeicosatetraenoic acids (HET

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12

Erdal, Can Alkoclar. "AN ADJUVANT ANTI-CARCINOGENIC FORMULATION WITH MEK SUPPRESSIVE PROPERTIES." May 9, 2020. https://doi.org/10.5281/zenodo.3818428.

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  <strong>Field of Invention</strong>   The present invention herewith discloses a formulation developed to display an anti-carcinogenic affect by mek suppression method.   <strong>Background of the Related Technology</strong> At present it is known that an anti-carcinogenic substance is any agent that prevents the development of cancer or prevents the growth of tumor. In state of art technology, invention no “WO 1997/048409", with title “Using Naaladase Inhibitors In Treatment Of Cancer” and under classification number “A61K 38/05" discloses di

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13

Yoshitake, Ryohei, Kohei Saeki, Shotaro Eto, et al. "Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-64832-5.

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Abstract Cancer-promoting inflammation is an important event in cancer development. Canine urothelial carcinoma (cUC) overexpresses prostaglandin E2 (PGE2) and has a unique sensitivity to cyclooxygenase 2 (COX2)-inhibiting therapy. In addition, majority of cUC harbour BRAFV595E mutation. However, mechanisms underlying aberrant PGE2 production in BRAFV595E cUC patients remain unclear. Drug screening revealed that inhibition of RAF/MEK/ERK pathway, p38 and JNK pathway reduced PGE2 production in cUC cells. By pharmacological inhibition of the multiple components in the pathway, activation of the

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14

Han, Rui, Jianghua Li, and Yong He. "The preliminary safety results of an observational phase II study of concurrent use of aspirin with dabrafenib and trametinib in BRAF V600 NSCLC." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e20632.

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e20632 Background: Dabrafenib combined with trametinib (DabTram) is highly effective in treating BRAF V600-mutant non-small cell lung cancer (NSCLC). However, pyrexia is the most common adverse event (AE), affecting over 50% of patients and often leading to dose reductions or interruptions, significantly impacting clinical application. Aspirin, a COX inhibitor, not only reduces PGE2 to alleviate pyrexia but may also modulate resistance pathways involving PI3K-AKT-mTOR and RAS-RAF-MEK, providing additional therapeutic benefits. This study evaluates the safety and potential of concurrent aspirin

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15

Du, Li, Honglei Wang, Fang Liu, et al. "NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs." Frontiers in Immunology 12 (April 29, 2021). http://dx.doi.org/10.3389/fimmu.2021.657071.

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In 2006, atypical porcine reproductive and respiratory syndrome (PRRS) caused by a highly pathogenic PRRSV (HP-PRRSV) strain broke out in China. Atypical PRRS is characterized by extremely high fever and high mortality in pigs of all ages. Prostaglandin E2 (PGE2) derived from arachidonic acid through the activation of the rate-limiting enzyme cyclooxygenase type 1/2 (COX-1/2) plays an important role in fever. Here, we showed that HP-PRRSV infection increased PGE2 production in microglia via COX-2 up-regulation depending on the activation of MEK1-ERK1/2-C/EBPβ signaling pathways. Then, we scree

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16

Baris, Elif, Huseyin Saygin Portakal, Arda Aslan, Zeynep Firtina Karagonlar та Metiner Tosun. "Liraglutide modulates cyclooxygenase and α7 acetylcholine receptors: in vitro and in silico insights into its anti-inflammatory role in LPS-induced inflammation in RAW 264.7 macrophages". Naunyn-Schmiedeberg's Archives of Pharmacology, 31 травня 2025. https://doi.org/10.1007/s00210-025-04225-5.

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Abstract Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is well-established for its metabolic benefits, including glycemic control and weight loss. Beyond these roles, it exhibits significant anti-inflammatory properties, though the mechanisms remain underexplored. This study investigates the anti-inflammatory effects of liraglutide in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Results demonstrate that increasing concentrations of liraglutide suppresses LPS-elevated prostaglandin E2 (PGE2), 6-keto prostaglandin F1α (6-keto-PGF1α, a stable prostacyclin m

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17

Abdel-Maksoud, Mohammed S., Hebatollah E. Eitah, Rasha M. Hassan, and Walaa Hamada Abd-Allah. "Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK." Molecular Diversity, February 22, 2025. https://doi.org/10.1007/s11030-025-11121-w.

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Abstract Two new series of pyrimidinyl ethyl pyrazoles derivatives 13a–f and 14a–f were designed and synthesized to possess both anticancer effect by inhibiting BRAFV600E and anti-inflammatory effect by inhibiting JNK isoforms. The structure of the new compounds was generated from hybridization of two main moieties. The pyrimidinyl moiety from reported BRAFV600E inhibitors, and the pyrazole moiety from JNK isoforms inhibitors. The new final compounds were tested on BRAFV600E, JNK1, JNK2, and JNK3 to measure their kinases inhibitory effect. Compound 14c showed the highest activity on JNK isofor

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18

Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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