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Dissertations / Theses on the topic 'Melanoma Carcinoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Carless, Melanie, and n/a. "Molecular Analysis of Non-Melanoma Skin Cancer." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041101.123114.

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Non-melanoma skin cancer (NMSC) is the most common cancer in the world with a lifetime risk for development as high as 2 in 3 in Queensland, Australia. Mortality is quite low, representing an approximate 360 deaths in Australia annually but cost of treatment is extremely high, estimated at $232 million each year. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the two most common forms of NMSC. Although BCC generally do not have the propensity to metastasise, they are highly invasive and can be locally destructive. SCC on the other hand is invasive and has metastatic potential

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2

Brownlie, Laura. "Differential gene expression studies in non-melanoma skin cancer." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323449.

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3

Ashton, Kevin John, and K. Ashton@griffith edu au. "Genetic Aberrations in Non-Melanoma Skin Cancer." Griffith University. School of Health Science, 2002. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030818.122305.

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Genetic changes are hallmarks of cancer development involving the activation and/or inactivation of oncogenes and tumour suppressor genes, respectively. In non-melanoma skin cancer (NMSC) development, the initiation of genetic mutations results from exposure to solar ultraviolet radiation. Non-melanoma skin cancers are comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Several related cutaneous lesions also exist, of which solar keratoses (SK) are widely accepted as a precursor dysplasia to SCC development. The study of recurrent genetic changes present within NMSC and

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4

Benaduce, Ana Paula. "UV-Induced Melanoma Mouse Model Dependent on Endothelin 3 Over-Expression." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1613.

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Melanoma is one of the most aggressive types of cancer. It originates from the transformation of melanocytes present in the epidermal/dermal junction of the human skin. It is commonly accepted that melanomagenesis is influenced by the interaction of environmental factors, genetic factors, as well as tumor-host interactions. DNA photoproducts induced by UV radiation are, in normal cells, repaired by the nucleotide excision repair (NER) pathway. The prominent role of NER in cancer resistance is well exemplified by patients with Xeroderma Pigmentosum (XP). This disease results from mutations in t

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5

Sorolla, Bardají Anabel. "Estudi del proteasoma i altres dianes terapèutiques en el melanoma i el carcinoma d’endometri." Doctoral thesis, Universitat de Lleida, 2012. http://hdl.handle.net/10803/83625.

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Donada la resistència a la quimioteràpia que presenta el melanoma i el carcinoma d’endometri avançat, és important la investigació destinada a buscar dianes terapèutiques. En aquest treball hem investigat els efectes de d’anàlegs de la somatostatina (SA), d’inhibidors del proteasoma (PI) com Bortezomib, de l’inhibidor de receptors tirosina cinasa Sunitinib i la combinació de Sunitinib i Bortezomib en línies cel•lulars de melanoma. Aquesta combinació també l’hem testat en el carcinoma d’endometri. S’observa que les cel•lules de melanoma expressen varis receptors de la somatostatina. Els PI són

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6

Ferreira, Flavia Regina [UNIFESP]. "Fatores de risco associados ao câncer de pele não melanoma em receptores de transplante renal." Universidade Federal de São Paulo (UNIFESP), 2014. http://repositorio.unifesp.br/handle/11600/23255.

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Made available in DSpace on 2015-12-06T23:46:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2014<br>Introdução: O cancer de pele nao melanoma e a forma mais comum de cancer em humanos e constitui a afeccao maligna que mais cresce entre os receptores de transplante renal. Objetivos: Caracterizar a populacao de receptores de transplante renal com cancer de pele nao melanoma; identificar os fatores de risco e calcular a chance para o desenvolvimento deste tipo de tumor nesta populacao. Metodos: Dois grupos foram constituidos: com cancer de pele nao melanoma (grupo caso) e nao (grupo cont

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7

Sandberg, Carin. "Aspects of fluorescence diagnostics and photodynamic therapy in non-melanoma skin cancer /." Göteborg : Department of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences, Sahlgrenska Academy University, University of Gothenburg, 2009. http://hdl.handle.net/2077/21192.

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8

Ferreira, Adilson Kleber. "Alquil fosfatado sintético precursor dos fosfolipídios da membrana celular com potencial efeito antitumoral e apoptótico em modelos de tumores experimentais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-20052013-145336/.

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Neste estudo foram avaliados os efeitos antitumorais da fosfoetanolamina sintética (FS) em modelos de tumores experimentais e as vias de sinalizações envolvidas nesta atividade. In vitro a FS foi citotóxica para as linhagens de células tumorais de melanoma humano, SK-MEL-28, carcinoma renal murino RENCA e para as células do carcinoma de pulmão de não pequenas células NSCLC. Alterações ultraestruturais como a condensação da cromatina, formação de blubes de membranas e mitocôndrias eletrodensas foi acompanhada pela redução do potencial elétrico mitocondrial. Aumento da ativação da caspase 3 e 8

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9

Pereira, Samir. "Risco de câncer de pele em indivíduos com menos de quarenta anos de idade em Goiânia." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3385.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2014-10-17T13:12:28Z No. of bitstreams: 2 Dissertacao Samir Pereira - 2013.pdf: 2721205 bytes, checksum: c3b5f53437d5aadf2091980bf889ad34 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2014-10-20T17:14:00Z (GMT) No. of bitstreams: 2 Dissertacao Samir Pereira - 2013.pdf: 2721205 bytes, checksum: c3b5f53437d5aadf2091980bf889ad34 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Made available in DSpa

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10

Terstappen, Karin. "Aspects on in vivo imaging techniques for diagnostics of pigmented skin lesions /." Göteborg : Department of Dermatology and Venereology, Institute of Clinical Science, The Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/17794.

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11

Ichii-Jones, Fumiyo. "A study of genetic factors that determine clinical phenotype in skin cancer : basal cell carcinoma and malignant melanoma." Thesis, Keele University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368988.

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12

Smeds, Johanna. "Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-105-5/.

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13

Maubec, Eve. "Prédisposition génétique au mélanome : de la génétique à la recherche clinique." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T034.

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Ce travail avait deux objectifs: 1) définir des groupes de patients (pts) susceptibles de bénéficier d’un conseil génétique par l’identification de facteurs prédictifs de l’existence d’une mutation du gène CDKN2A, un des gènes majeurs de prédisposition au mélanome, dans les familles ne comportant que deux cas (Fam_2 cas). 2) la caractérisation épidémiologique et clinique d’entités particulières du mélanome dans l’objectif secondaire de contribuer à l’identification de gènes de prédisposition à ces entités. Les 2 entités étudiées étaient le mélanome cutané (MC) associé au cancer du rein (CR) et

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14

Wallingford, Sarah. "Investigations into the epidemiology and aetiology of cancers of the skin." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/investigations-into-the-epidemiology-and-aetiology-of-cancers-of-the-skin(97008a57-643e-4244-85c1-4e0a753e4d6f).html.

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The cancers of the skin, melanoma and the keratinocyte cancers, basal cell andsquamous cell carcinomas (BCC and SCC), are among the most common cancersin white populations. While ultraviolet radiation (UVR) is their principal cause,links with non-UVR-related factors have also been noted. Ultimately, theinteraction of these elements results in malignancy however, understanding oftheir specific contributions remains incomplete. This thesis reports findings fromsix studies aiming to investigate gaps in current knowledge of the role of UVR andnon-UVR-related risk factors on skin cancer. The papers

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15

Biggers, Jonathan. "CELL DEATH AND SUSTAINED SENESCENCE ARREST IN COLON CARCINOMA AND MELANOMA TUMOR CELLS IN RESPONSE TO THE NOVEL MICROTUBULE POISON, JG-03-14." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2206.

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Previous studies from this and other laboratories have shown that the novel microtubule poison, JG-03-14, which binds to the colchicine binding site of tubulin, has the capacity to promote both autophagy and apoptosis in breast tumor cells, as well as interfering with endothelial cell function and potentially disrupting tumor vasculature. The current work was designed to investigate the interaction between JG-03-14 and cell culture models of colon carcinoma and melanoma, specifically HCT116 human colon carcinoma cells and B16F10 murine melanoma cells. In both cases, JG-03-14 promoted death in

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16

Cheryl, Lai Lai Chiang. "Assessing the potential of hypochlorous acid-oxidised allogeneic tumour cells as a source of antigens for dendritic cell-based immunotherapy of ovarian carcinoma and melanoma." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505526.

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17

Strioga, Marius. "Expression of biomarkers, representing immunosuppressive, cytotoxic or immunomodulating properties of CD8h T lymphocytes in the peripheral blood of patients with immunogenic cancer forms." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105111-42651.

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The aim of the study was to evaluate the expression of immunosuppressive (FOXP3, NKG2A), and cytotoxic (perforin) or cytotoxic / immunomodulating (IFNγ) T-cell properties representing biomarkers in the peripheral blood CD8h T-cell population of patients with advanced renal cell carcinoma (RCC) or high risk cutaneous melanoma and healthy controls by multicolour flow cytometry. Determination of the percentage of functionally competing T-cell subsets (especially immunosuppressive) in the CD8hCD57+ T-cell subpopulation in future may serve as one of parameters enabling to assess the overall status

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18

Strioga, Marius. "Imunosupresines, citotoksines bei imunomoduliuojančias savybes atspindinčių žymenų raiška imunogeniškomis vėžio formomis sergančių pacientų periferinio kraujo CD8h T limfocitų populiacijoje." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105125-92547.

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Darbo tikslas buvo įvertinti imunosupresines (FOXP3, NKG2A), citotoksines (perforin) bei citotoksines / imunomoduliuojančias (IFNγ) savybes atspindinčių žymenų raiškos skirtumus išplitusiu inkstų vėžiu ar didelės rizikos odos melanoma sergančių pacientų periferinio kraujo CD8h T limfocitų populiacijoje, lyginant su kontroline grupe. Skirtingas T limfocitų savybes atspindinčių žymenų raiška buvo tiriama tėkmės citometrijos būdu. Nustatyta, kad inkstų vėžiu ar odos melanoma sergančių pacientų periferiniame kraujyje Įvairių subpopuliacijų (ypač imunosupresinės) nuošimčio nustatymas CD8hCD57+ T li

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19

Hira, Akshay. "TIP60 regulation of DNp63a is associated with cisplatin resistance." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1566585763492406.

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20

Becker, Cornelia [Verfasser]. "Dose-response relationship between chemotherapy for childhood cancer and the risk for a carcinoma or malignant melanoma as subsequent neoplasm - a scoping review of the literature and a case-control study / Cornelia Becker." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/123741217X/34.

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21

Stacy, Andrew Jared. "Regulation of ΔNp63α by TIP60 promotes cellular proliferation". Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1596151919161674.

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22

Fohlen, Audrey. "Optimisation des stratégies thérapeutiques en radiologie interventionnelle : application en embolisation et en oncologie Transhepatic forceps biopsy combined with biliary drainage in obstructive jaundice: safety and accuracy ransarterial chemoembolization (TACE) in the management of hepatocellular carcinoma: Results of a French national survey on current practices." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC424.

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La radiologie interventionnelle (RI) présente des avantages indéniables. Grâce aux techniques d’embolisation, les patients présentant des hémorragies pouvant engager le pronostic vital, peuvent être traités. Les agents liquides collants peuvent être utilisés or, leur technique d’utilisation reste très empirique. Les complications des embolisations à la colle peuvent être gravissimes. Leur maniabilité peut être appréhendée. Dans la 1ère partie de ce travail nous avons étudié in vitro les caractéristiques de plusieurs colles et notamment les dernières mises sur le marché (Glubran 2 et Purefill,

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23

Frerot, Isabelle. "Mélanome et carcinome mammaire : associations et caractéristiques communes : série personnelle et revue de la littérature." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M040.

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24

FERRADINI, LAURENT. "Etude du repertoire des lymphocytes t alpha/beta infiltrant le melanome malin et le carcinome du nasopharynx." Paris 7, 1992. http://www.theses.fr/1992PA077060.

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Les tumeurs humaines sont infiltrees par des cellules mononuclees composees essentiellement de lymphocytes t exprimant le recepteur (tcr) alpha/beta. Nous avons etudie la specificite des lymphocytes infiltrants de la tumeur til par l'analyse in situ des tcr qu'ils expriment au cours du melanome et du carcinome du nasopharynx (npc). L'etude du repertoire a ete effectuee par pcr ancree (apcr) qui a permis la description de nouveaux segments de genes du tcr. Des oligonucleotides specifiques de chaque famille de segments variables du tcr permettent une analyse rapide du repertoire des lymphocytes

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25

Ibrahim, El Chérif. "Regulation de l'expression de gene hla-g lors de la reponse au stress et analyse de l'activation selective de ce gene dans les melanomes et les carcinomes renaux." Paris 5, 2001. http://www.theses.fr/2001PA05N085.

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26

Fregni, Giulia. "The role of human Natural Killer cells (NK) in anti-tumour immune responses." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T068/document.

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Les cellules Natural Killer (NK) sont des effecteurs cytotoxiques impliqués dans la réponse immune contre les infections et les tumeurs. Pendant ma thèse j’ai étudié la fonctionnalité des cellules NK humaines en réponse à des lignées cellulaires de carcinome rénal à cellules claires (RCC) et de mélanome métastatique, deux tumeurs immunogènes. Nos résultats montrent que certaines mutations de VHL augmentent la susceptibilité des lignées RCC à la lyse NK. La perte de fonction de VHL corrèle avec une expression membranaire diminuée des molécules HLA-I par les lignées RCC mutées pour VHL. Chez les

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27

Almeida, Diana Maria Sousa Simões de. "Alterações genéticas e cancro cutâneo." Master's thesis, 2014. http://hdl.handle.net/10316/37287.

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28

Tran, Eric. "A Cytokine Odyssey: From Interleukin-2 Signaling to Cytokine Therapy for Cancer." Thesis, 2010. http://hdl.handle.net/1828/5004.

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T cells are a crucial component of the immune system and play an important role in responses to pathogens, tumours, and transplanted tissues. In many human cancers, elevated numbers of tumour-infiltrating CD8+ killer T cells are associated with favourable outcomes, suggesting that enhancing T-cell responses could provide major therapeutic benefit for cancer patients. Thus, identifying factors that can promote protective T-cell responses is of great clinical importance. The cytokine interleukin-2 (IL-2) is a major inducer of T-cell proliferation and differentiation, and is used clinically to tr

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29

Frydenlund, Noah. "Neurotrophin receptors in select cutaneous malignancies with a propensity for perineural invasion." Thesis, 2015. https://hdl.handle.net/2144/16317.

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Perineural invasion (PNI) in cutaneous squamous cell carcinoma (cSCC) and desmoplastic melanoma (DM) may be a negative prognostic finding, and likely contributes to increased rates of local recurrence. The biological mechanisms underlying PNI remain unclear, although several lines of evidence implicate neurotrophins and their receptors. Expression of the high affinity nerve growth factor (NGF) receptor TrkA has been shown to be associated with PNI in numerous malignancies, although literature in cutaneous neoplasms is sparse. Given this, we sought to ascertain the incidence of PNI in a cohort

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30

Batista, Cátia Sofia Martins. "Modelos animais usados para a abordagem terapêutica do cancro da pele." Master's thesis, 2015. http://hdl.handle.net/10451/26940.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015<br>A utilização de modelos animais na experimentação biomédica é essencial, pois somente através dos mesmos se obtêm novos conceitos importantes acerca do organismo humano e sobre a eficácia e segurança de novos tratamentos, a fim de prolongar a vida humana com qualidade. O cancro da pele ou cancro cutâneo tem elevada prevalência, o que leva a uma acentuada morbilidade e mortalidade, que podem ser diminuídas através de um tratamento precoce. Aliás, esta neoplasia tem elevadas taxas

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31

Pereira, Maria Teresa da Silveira Ribeiro Silva. "Crioterapia no tratamento de tumores cutâneos." Master's thesis, 2016. http://hdl.handle.net/10316/37160.

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Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de dermatologia) no âmbito do ciclo de estudos de Mestrado Integrado em Medicina.<br>A crioterapia é um método terapêutico não invasivo, que consiste na ablação de lesões cutâneas através da congelação celular. Esta modalidade terapêutica foi introduzida na prática clínica no início do século XX. O azoto líquido é o agente criogénico de escolha na atualidade. Tem indicação no tratamento de lesões cutâneas benignas e de lesões malignas, como o basalioma, o carcinoma espinhocelular e o lentigo maligno. Atra

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32

Trautmann, Freya. "Inanspruchnahme und Wirksamkeit von Maßnahmen der Früherkennung und Therapie onkologischer Erkrankungen: Analysen zu ausgewählten Krankheitsbildern basierend auf Routinedaten der Gesetzlichen Krankenversicherung." 2019. https://tud.qucosa.de/id/qucosa%3A38049.

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Hintergrund: Tumorerkrankungen stellen aufgrund ihrer Häufigkeit, der Komplexität der Behandlung und der entstehenden Krankheitskosten das Gesundheitssystem vor wachsende Herausforderungen. Im Kontext des demographischen Wandels und des medizinischen Fortschrittes gilt es, eine langfristige, sektorenübergreifende Versorgung der Betroffenen und Überlebenden sicherzustellen. Die Implementierung geforderter Maßnahmen zur Früherkennung und Behandlung in die Routineversorgung erfolgt jedoch häufig nur mit unzureichender wissenschaftlicher Begleitung, sodass eine Beurteilung der Wirksamkeit im Behan

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33

Paley, Olga M. "Engineering a novel human methionine degrading enzyme as a broadly effective cancer therapeutic." Thesis, 2014. http://hdl.handle.net/2152/31302.

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Many cancers have long been known to display an absolute requirement for the amino acid methionine (L-Met). Studies have shown that in the absence of L-Met, sensitive neoplasms experience cell cycle arrest and perish. Without the metabolic deviations that characterize L-Met auxotrophs, normal cells are able to grow on precursors such as homocysteine and tolerate periods of L-Met starvation. The differential requirement for this amino acid between normal and tumor cells has been exploited through enzymatic serum degradation of L-Met by a bacterial methionine-γ-lyase (MGL). Though MGL was able t

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"Selenocystine induces mitochondrial-mediated apoptosis in breast carcinoma MCF-7 cells and melanoma A-375 cells with involvement of p53 phosphorylation and reactive oxygen species." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074646.

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Additionally, we showed that SeC induced S-phase arrest in MCF-7 cells associated with a marked decrease in the protein expression of cyclin A, D1 and D3 and cyclin-dependent kinases (CDK) 4 and 6, with concomitant induction of p21waf1/Cip1, p27Kip1 and p53. Expose of MCF-7 cells to SeC resulted in delayed onset of apoptosis as evidenced by caspase activation, PARP cleavage and DNA fragmentation. SeC treatment also triggered the activation of JNK, p38 MAPK, ERK and Akt phosphorylation. Inhibitors of ERK (U0126) or Akt (LY294002), but not JNK (SP600125) and p38 MAPK (SB203580), significantly su

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35

Tzi-Peng and 楊子芃. "1.Mithramycin A inhibits human epithelial carcinoma cells 1.proliferation and migration involving downregulation of Eps8 expression 2.Mechanism of cell death induced by Caffeic acid on melanoma cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99219699772727063271.

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博士<br>中山醫學大學<br>生化暨生物科技研究所<br>100<br>Part1 Mithramycin A is an inhibitor of the binding of the Sp family transcription factor to the GC box. Many studies show that Mithramycin A may reduce the expression of many proto-oncogenes by inhibiting the mRNA and protein synthesis and it has been used as an antibiotic chemotherapy drug for a long time. Recently, Eps8 (EGFR pathway substrate 8) has been revealed to be a novel proto-oncogene related to cellular transformation, Rac activation and actin barbed-end-capping activity. Therefore, the aim of this study was to verify whether Eps8 might be regula

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Kodet, Ondřej. "Studium epitelově mezenchymových interakcí v nádorech vycházejících z dlaždicových epitelů." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-332316.

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This thesis is focused on the epithelial mesenchymal interactions in tumors derived from squamous epithelium including tumors arising from minor cell population (melanocytes). This study is also reflecting aspects of epithelial glycobiology resp. the study of endogenous lectins, the galectins, in head and neck squamous carcinomas. Galectins represent, in the current concepts of cell and tumor biology molecules with a remarkable potential. Galectins participate, besides in regulation of pre- and postnatal homeostasis in normal tissues, also in many pathological processes such as autoimmune reac

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37

Jechová, Alžběta. "Studium mezibuněčných interakcí v nádorech." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-395901.

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Beside tumor cells themselves, tumors consist of many non-malignantly transformed cellular elements and an extracellular matrix. This so-called tumor microenvironment, or stroma, significantly influences the biological properties of the tumor through intercellular interactions. In this thesis I have focused on the study of tumor-associated fibroblasts in squamous cell carcinomas of the head and neck, malignant melanoma and glioblastoma. The data show the presence of cells with mesenchymal characteristics, present even in the glioblastoma stroma, which could potentially have a positive effect o

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