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Journal articles on the topic 'Melanoma Carcinoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Mulcahy, Elizabeth, Rossymar Colon, Ying Zhang, et al. "CSIG-01. IDENTIFICATION OF PATHOGENESIS-RELEVANT microRNAs IN BRAIN METASTASIS." Neuro-Oncology 22, Supplement_2 (2020): ii27. http://dx.doi.org/10.1093/neuonc/noaa215.113.

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Abstract When brain metastasis develops, the prognosis of cancer is dismal. Insights into the biology of the primary cancer and the brain metastasis are necessary to inform more effective and targeted treatments. To study the role of microRNAs in brain metastasis, we performed differential expression profiling of 12 primary tumors and their paired brain metastases using smRNAseq (the 12 primary tumors included three non-small cell carcinomas, three melanomas, three endometrial carcinomas, one breast carcinoma, one thyroid carcinoma and one renal-cell carcinoma). To start, we identified microRN

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2

Venugopal, Balaji, and TR Jeffry Evans. "Coexistent Malignant Melanoma and Renal Cell Carcinoma." Tumori Journal 95, no. 4 (2009): 518–20. http://dx.doi.org/10.1177/030089160909500419.

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Patients with malignant melanoma are at an increased risk of developing subsequent primary melanomas and also nonmelanoma cutaneous cancers. Several studies have reported an association between malignant melanoma and breast cancer, bladder cancer, colorectal cancer, neuroectodermal tumours, non-Hodgkin's lymphoma, leukaemia and renal cell carcinoma. We report a case series of patients with a diagnosis of malignant melanoma who also developed a renal mass. In two of these cases, the renal mass became apparent on diagnostic imaging as part of the staging investigations at the time of initial dia

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Oliveira, Miguel, Joana Cabete, Carina Semedo, et al. "A Metastização Cervical dos Cancros Cutâneos de Cabeça e Pescoço." Journal of the Portuguese Society of Dermatology and Venereology 75, no. 1 (2017): 27–35. http://dx.doi.org/10.29021/spdv.75.1.715.

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O cancro cutâneo é a neoplasia mais frequente de todas, com maior incidência na área de cabeça e pescoço, pela fotoexposição crónica. A estratificação do risco metastático linfático regional cervical tende a ser sistematizada de acordo com modelos de estadiamento tumoral, que são tendencialmente aceites no melanoma e carcinoma de células de Merkel, mas pouco consensuais no carcinoma espinocelular. Um dos focos de investigação é o risco de micrometástases em casos de tumores de estádio clínico e imagiológico N0, de que um modo geral varia entre 5% a 20% nos carcinomas espinocelulares, cerca de

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Morales Duarte, Karla Elizabeth, and Ricardo Alberto Leal. "Diagnóstico del carcinoma basocelular pigmentado." ALERTA Revista Científica del Instituto Nacional de Salud 3, no. 1 (2020): 18–22. http://dx.doi.org/10.5377/alerta.v3i1.8684.

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    El carcinoma basocelular es una de las neoplasias más comunes en seres humanos y es el más frecuente dentro del grupo de carcinomas cutáneos no melanoma. Se origina en células basales de la epidermis y folículos pilosos. Suele ser de lento crecimiento y poco agresivo y genera metástasis en la mayoría de los casos. El carcinoma basocelular tiene diferentes tipos, el nodular, ulcerativo, esclerodermiforme, pigmentado y el superficial. El tipo pigmentado posee la peculiaridad de ser confundido con otras patologías, como por ejemplo, con una queratosis seborreic

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5

Sergeev, Y. Y., V. V. Mordovtseva, O. R. Katunina, and V. Y. Sergeev. "Multiple primary skin cancer: case report and literature review." Medical alphabet 1, no. 7 (2019): 78–82. http://dx.doi.org/10.33667/2078-5631-2019-1-7(382)-78-82.

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Multiple primary form of melanoma is one of the variants of the clinical course of this tumor. Typically two primary lesions are diagnosed and secondary tumor differs much in terms of clinical and pathological characteristics. Besides subsequent melanomas, patients are at higher risk of developing non-melanoma skin cancer, tumors of the breast, prostate gland, kidneys and the gastrointestinal tract. The article describes the case of multiple primary skin cancer, manifested by two primary melanomas and basal cell carcinoma, and literature review on this issue.

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Khatoon, Ayesha, Vyshnavi Vasantham, Urvashi Sharma, et al. "Ano-rectal Melanoma: A Rare Case Report." Annals of Pathology and Laboratory Medicine 7, no. 7 (2020): C91–93. http://dx.doi.org/10.21276/apalm.2789.

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Ano-rectal melanoma is extremely rare and has dismal prognosis when compared to cutaneous melanomas. It presents as ano-rectal mass and patients usually complain of passing blood in stools. Being, a highly aggressive neoplasm, widespread metastasis is common, which can be seen even at the time of diagnosis. Here, we present a case report of ano-rectal melanoma in a 40-year old male, who presented with complaints of anal growth since one month. Initially, a clinical diagnosis of rectal carcinoma was suspected. However, biopsy of the growth showed histomorphological features of melanoma, which w

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Hasbún Acuña, Paula, Roberto Cullen Aravena, César Maturana Donaire, Raúl Ares Mora, and Ninoska Porras Kusmanic. "Pigmented basal cell carcinoma mimicking a superficial spreading melanoma." Medwave 16, no. 11 (2016): e6805-e6805. http://dx.doi.org/10.5867/medwave.2016.11.6805.

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8

Bratchenko, Ivan, Yulia Khristoforova, Lyudmila Bratchenko, et al. "Optical Biopsy of Amelanotic Melanoma with Raman and Autofluorescence Spectra Stimulated by 785 nm Laser Excitation." Journal of Biomedical Photonics & Engineering 7, no. 2 (2021): 020308. http://dx.doi.org/10.18287/jbpe21.07.020308.

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In this work, Raman and autofluorescence spectroscopy in the near-infrared region has been used for examining amelanotic melanoma as the most dangerous type of malignant melanoma. There were 9 patients with amelanotic melanoma, 60 with pigmented melanoma and 120 with basal cell carcinoma enrolled in this study. We studied 9 amelanotic melanoma cases to differentiate them from basal cell carcinoma (n = 120) and pigmented malignant melanoma (n = 60) using portable spectroscopy setup with laser excitation source at 785 nm and low-cost spectrometer. The spectra of the different tumor type were cla

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9

Komatsubara, Kimberly M., Joanne Jeter, Richard D. Carvajal, Kim Margolin, Dirk Schadendorf, and Axel Hauschild. "Advances in the Treatment of Advanced Extracutaneous Melanomas and Nonmelanoma Skin Cancers." American Society of Clinical Oncology Educational Book, no. 37 (May 2017): 641–50. http://dx.doi.org/10.1200/edbk_175265.

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Cutaneous malignancies make up the greatest proportion of all human cancers and include melanomas as well as nonmelanoma skin cancers (NMSCs) such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), as well as less common Merkel cell carcinoma (MCC), cutaneous lymphomas, cutaneous adnexal tumors, Kaposi sarcomas, and other sarcomas. Each of these NMSCs differ significantly in biology, clinical behavior, and optimal treatment recommendations from each other and from cutaneous melanoma. Similarly, less common extracutaneous melanomas, such as mucosal (MMs) and uveal (UMs)

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Bacchi, Carlos E., Sheila C. Wludarski, Abiy B. Ambaye, Janez Lamovec, Tiziana Salviato, and Giovanni Falconieri. "Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers." Archives of Pathology & Laboratory Medicine 137, no. 1 (2013): 41–49. http://dx.doi.org/10.5858/arpa.2011-0552-oa.

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Context.—The mammary gland can be a site of metastasis in patients with malignant melanoma, which is easily recognized microscopically if clinical information is available. Nonetheless, metastatic melanoma presenting as an isolated mammary tumor can be more challenging to diagnose because it can simulate a primary breast carcinoma clinically and morphologically. Objective.—To review metastatic melanoma to the breast, presenting as primary breast carcinomas clinically and morphologically. Design.—The authors report 20 cases of metastatic melanoma clinically presenting as breast tumors. Cases wi

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11

Abbas, Mariam, and Sunil Kalia. "Trends in Non-Melanoma Skin Cancer (Basal Cell Carcinoma and Squamous Cell Carcinoma) in Canada." Journal of Cutaneous Medicine and Surgery 20, no. 2 (2015): 166–75. http://dx.doi.org/10.1177/1203475415610106.

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Background: Despite its increased incidence and status as the most prevalent cancer in Canada, there is a paucity of epidemiological data on non-melanoma skin cancer (NMSC). Objective: To assess trends of keratinocyte carcinomas (KC) in Canada over 5 decades. Methods: Articles published from 1960 to 2015 on NMSC in Canada were identified through MEDLINE. Six articles met our search criteria. Results: Overall, KC has increased. However, the rate of increase in the past decade has slowed down and decreased in younger age cohorts. Men had higher incidences of KC. In both sexes, the basal cell car

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Bonivento Johnsson, Petty, Guillermo Trout Guardia, Jamith Maestre Garzon, Mayra Muñoz Vergara, and Maria Carolina Moreno Ochoa. "Carcinoma espinocelular: reporte de caso en paciente con fototipo tipo 5 según clasificación Fitzpatrick." Revista Med 26, no. 2 (2019): 52–59. http://dx.doi.org/10.18359/rmed.2823.

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El carcinoma espinocelular es un subtipo de neoplasia que no involucra a los melanocitos, y junto con el carcinoma basocelular, representan el 75% de los carcinomas de piel no melanoma. En Colombia, se calculó que de 2003 a 2007 el cáncer no melanoma registró un incremento de 19 a 39 casos por 100 000 habitantes. El carcinoma espinocelular tiende a aparecer en fototipos de piel 1 y 2, en áreas fotoexpuestas que representan cabeza y cuello (70%), en extremidades superiores (25%) y en zonas no fotoexpuetas como glúteos y mucosas genitales (5%). Este artículo hace un reporte de caso de un carcino

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13

Ji, Chao, Yue Zhang, Patricia Heller, and Ying Guo. "Melanocytic Matrical Carcinoma Mimicking Melanoma." American Journal of Dermatopathology 39, no. 12 (2017): 903–6. http://dx.doi.org/10.1097/dad.0000000000000771.

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14

Lin, Ching-Shen. "Melanoma Marker and Breast Carcinoma." American Journal of Clinical Pathology 94, no. 5 (1990): 669. http://dx.doi.org/10.1093/ajcp/94.5.669.

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15

Hamilton, Amanda, Prasad Jayaratne, and Mark Zonta. "Metastatic Merkel cell carcinoma and malignant melanoma in a single sentinel lymph node." SAGE Open Medical Case Reports 9 (January 2021): 2050313X2110236. http://dx.doi.org/10.1177/2050313x211023685.

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Merkel cell carcinoma (MCC) and malignant melanoma are aggressive skin cancers that usually arise in sun-exposed parts of the body. This report describes an 85-year-old man who underwent a wide local excision and sentinel lymph node biopsy for primary MCC and was subsequently found to have metastatic MCC and malignant melanoma within the left inguinal sentinel lymph node. Dual diagnoses of aggressive cutaneous carcinomas, although rare, may become more common in regions of high ultraviolet exposure and an ageing population. Currently, there are no guidelines for treating synchronous MCC and me

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16

Green, Adèle C., Gail M. Williams, Valerie Logan, and Geoffrey M. Strutton. "Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up." Journal of Clinical Oncology 29, no. 3 (2011): 257–63. http://dx.doi.org/10.1200/jco.2010.28.7078.

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Purpose Regular sunscreen use prevents cutaneous squamous cell carcinoma long term, but the effect on melanoma is highly controversial. We evaluated whether long-term application of sunscreen decreases risk of cutaneous melanoma. Participants and Methods In 1992, 1,621 randomly selected residents of Nambour, a township in Queensland, Australia, age 25 to 75 years, were randomly assigned to daily or discretionary sunscreen application to head and arms in combination with 30 mg beta carotene or placebo supplements until 1996. Participants were observed until 2006 with questionnaires and/or throu

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Surikova, Ekaterina I., Elena M. Frantsiyants, Irina V. Kaplieva, et al. "Suppression of tumor development by another tumor in primary immunodeficiency in experiment." Journal of Clinical Oncology 39, no. 15_suppl (2021): e21583-e21583. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21583.

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e21583 Background: Multiple primary malignant tumors (MPMTs) are characterized by the presence of several primary neoplasms in one patient. The purpose of the study was to create an experimental model of MPMTs with one dominating tumor. Methods: The study included 21 female BALB/c Nude mice. The main group included mice with simultaneous subcutaneous inoculation of tumors: Guerin's carcinoma (0.5 million tumor cells in 0.5 ml of saline solution) under the right scapula and B16/F10 melanoma (0.5 ml of suspension diluted 1:20 in saline solution) under the left scapula. Control groups included fe

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Martinez, Marcos Antonio Rodrigues, Guilherme Francisco, Luciana Sanches Cabral, Itamar Romano Garcia Ruiz, and Cyro Festa Neto. "Genética molecular aplicada ao câncer cutâneo não melanoma." Anais Brasileiros de Dermatologia 81, no. 5 (2006): 405–19. http://dx.doi.org/10.1590/s0365-05962006000500003.

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Os cânceres cutâneos não melanoma são as neoplasias malignas mais comuns em humanos. O carcinoma basocelular e o carcinoma espinocelular representam cerca de 95% dos cânceres cutâneos não melanoma, o que os torna um crescente problema para a saúde pública mundial devido a suas prevalências cada vez maiores. As alterações genéticas que ocorrem no desenvolvimento dessas malignidades cutâneas são apenas parcialmente compreendidas, havendo muito interesse no conhecimento e determinação das bases genéticas dos cânceres cutâneos não melanoma que expliquem seus fenótipos, comportamentos biológicos e

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Badve, Sunil S., Rachel Dougherty, Michael Balatico, Kenneth A. Kesler, Patrick Loehrer, and Yesim Gökmen-Polar. "Thymic Carcinomas and Second Malignancies: A Single-Center Review." Cancers 13, no. 10 (2021): 2472. http://dx.doi.org/10.3390/cancers13102472.

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Thymic carcinomas account for less than 0.01% of new cancer diagnoses annually and are more aggressive than thymomas. Autoimmune disorders have been associated with thymomas and only recently with thymic carcinomas. Second malignancies are well described after thymomas. The aim of this study was to analyze the incidence of second malignancies in patients with thymic carcinomas. All cases of thymic carcinomas were identified from the pathology archives of Indiana University. Histological materials were reviewed and further correlated with clinical data to identify incidence of second cancers in

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Mitsiogianni, Melina, Sotiris Kyriakou, Ioannis Anestopoulos, et al. "An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells." Antioxidants 10, no. 2 (2021): 284. http://dx.doi.org/10.3390/antiox10020284.

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Malignant melanoma is one of the most deadly types of solid cancers, a property mainly attributed to its highly aggressive metastatic form. On the other hand, different classes of isothiocyanates, a class of phytochemicals, present in cruciferous vegetables have been characterized by considerable anti-cancer activity in both in vitro and in vivo experimental models. In the current study, we investigated the anti-cancer response of five isothiocyanates in an in vitro model of melanoma consisting of non-metastatic (A375, B16F-10) and metastatic (VMM1, Hs294T) malignant melanoma as well as non-me

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Smolarova, M., and E. Minarikova. "Dermoscopy as a Valuable Tool in Diagnosis of Nodular Amelanotic Melanoma and Nodular Basal Cell Carcinoma." Acta Medica Martiniana 17, no. 1 (2017): 21–27. http://dx.doi.org/10.1515/acm-2017-0003.

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Abstract Nodular amelanotic melanoma has been always a great challenge in dermatology. Because of lack of melanin pigment, tumors are diagnosed usually in advanced stage. Amelanotic melanoma can mimic basal cell carcinoma. Knowledge of typical dermoscopic structures helps to establish diagnosis and to plan surgery with appropriate safety margins. In amelanotic melanoma we can see typical vessels, white streaks or milky red globules on pink-reddish background. Vessels are typically thin and polymorphous in thick amelanotic melanoma. We had a case when vessels were polymorphous but thick. It can

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Tomioka, Kodai, Hitoshi Ojima, Makoto Sohda, et al. "Primary Malignant Melanoma of the Rectum: Report of Two Cases." Case Reports in Surgery 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/247348.

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We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-

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Bastakoti, Shankar, Dej Kumar Gautam, Suraj Raj Upreti, Nandita Jha, and Ishan Dhungana. "A Notorious Mimicker Nasal Melanoma: A Case Report." Annapurna Journal of Health Sciences 1, no. 1 (2021): 30–32. http://dx.doi.org/10.52910/ajhs.13.

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Melanomas arising in the nasal cavity or paranasal sinus are rare and have a poor prognosis and is more aggressive than cutaneous counter part. The incidence rate reaches its peak when the patients are in the 5th to 8th decades of life, and the disease is slightly more common in males than females; age and sex do not affect the prognosis. We present a case with histologically deceiving features which was proven Malignant Melanoma by application of Immunohistochemistry. On sinoscopic examination, a mass noted of which incisional biopsy was obtained. Histologically, poorly differentiated Sinonas

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Gómez Sánchez, J., P. de Castro Monedero, and B. Mirón Pozo. "Basal cell carcinoma of perianal location." Cirugía Andaluza 31, no. 2 (2020): 193–95. http://dx.doi.org/10.37351/2020312.26.

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Resumen El carcinoma basocelular constituye el cáncer de piel más habitual, representando aproximadamente el 80% de los tumores malignos cutáneos no melanoma. Su origen, en las células basales epidérmicas, parece estar desencadenado por la sobreexposición solar, por eso aparece con frecuencia en la región facial, cervical y tronco. Su aparición en áreas no expuestas al sol, como la región perianal, es extremadamente rara, representando en esta región el 0,2% de todos los carcinomas basocelulares diagnosticados. Se presenta a continuación el caso clínico de un carcinoma basocelular tipo nodular

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Duque-Ruiz, Manuela, and Elsa Vásquez-Trespalacios. "Infrecuente cáncer no melanoma: carcinoma mucinoso." Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica 27, no. 2 (2019): 138–42. http://dx.doi.org/10.29176/2590843x.986.

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El carcinoma mucinoso es una entidad rara y maligna de las glándulas ecrinas. Fue descrito en 1952 y se caracteriza por la producción de mucina en los islotes del tumor; es de crecimiento lento y se presenta como nódulos asintomáticos ubicados en la cabeza, el cuello, alrededor de los párpados y en el cuero cabelludo. Puede reaparecer con el tiempo. El tratamiento de elección es la resección quirúrgica, aunque no se dispone de un estándar de tratamiento quirúrgico, frecuentemente se utilizan la clásica resección con 1 cm de margen y la cirugía de Mohs. Se presenta el caso de un hombre

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Venkataraman, Subramanian, Shajan Peter, and Anna B. Pulimood. "Colonic malignant melanoma mimicking colon carcinoma." Digestive Endoscopy 16, no. 3 (2004): 266–68. http://dx.doi.org/10.1111/j.1443-1661.2004.00354.x.

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Hosier, Gregory W., and Matthew T. Roberts. "Initial response of renal cell carcinoma to vemurafenib in a patient treated for metastatic melanoma." Canadian Urological Association Journal 10, no. 9-10 (2016): 306. http://dx.doi.org/10.5489/cuaj.3652.

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Vemurafenib is a selective inhibitor of overactive BRAF oncogene with a substitution of lysine for glutamic acid at residue 600 (BRAFV600E), a mutation expressed in approximately 50% of all melanomas. We report a case of a patient with metastatic melanoma treated with vemurafenib, who subsequently presented with a biopsy-proven conventional renal cell carcinoma (RCC). We observed an initial complete regression of the mass while on vemurafenib. This was unexpected, given that vemurafenib is a specific inhibitor of BRAFV600E and most RCCs do not harbour this mutation.

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Itoh, K., C. D. Platsoucas, and C. M. Balch. "Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor." Journal of Experimental Medicine 168, no. 4 (1988): 1419–41. http://dx.doi.org/10.1084/jem.168.4.1419.

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TIL from metastatic melanoma proliferated by greater than 1,000-fold (840-3,675, mean 1,543) after 6 wk in culture of mixtures of TIL and tumor cells with rIL-2 alone. Cytolysis was restricted to autologous tumor cells. CD8+ T cells were the predominant population of TIL before and after expansion, and were primarily responsible for autologous tumor-specific CTL activity. No other rIL-2-activated lymphocytes from peripheral blood, lymph nodes with melanoma metastasis, or TIL from sarcoma or renal cell carcinoma had autologous tumor-specific CTL activity. There were few or no CD16+ NK cells in

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Graziani, Silvia Regina, Carolina Graziani Vital, Hezio Jadir Fernandes, et al. "Evaluation of nutritional parameters in prechemotherapy of oncology patients in a service of the Unified Health System." Journal of Clinical Oncology 35, no. 15_suppl (2017): e21628-e21628. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21628.

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e21628 Background: Pre-chemotherapy nutritional evaluation is fundamental strategy as predictive factor for the possibility of response to oncological treatment and treatment-related toxicity. As in the Unified Health System patients usually arrive for evaluation with advanced disease, we believe that medical evaluation of the nutritional parameters is important in the therapeutic decision. Methods: From October 2015 through July 2016, we evaluated 210 patients referred for cancer treatment at the Arnaldo Vieira de Carvalho Cancer Institute in São Paulo (Brazil), which is an Institution that e

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Binkley, Elaine M., Aron D. Sampson, Nasreen A. Syed, and H. Culver Boldt. "Metastatic Squamous Cell Carcinoma of the Tonsil Mimicking Choroidal Melanoma." Ocular Oncology and Pathology 6, no. 6 (2020): 405–9. http://dx.doi.org/10.1159/000510288.

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We describe a case of a 53-year-old man with a history of metastatic squamous cell carcinoma of the tonsil who presented with a large, dome-shaped, choroidal mass in the left eye with concern for extra-ocular extension. Standardized echography showed a choroidal mass with low-to-medium internal reflectivity, pockets of very low reflectivity, positive angle kappa, and 1+ vascularity that were concerning for primary choroidal melanoma. Biopsy of the lesion was consistent with metastatic squamous cell carcinoma of the tonsil rather than melanoma. This is only the second reported case of metastati

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Mora H., Oscar, Manuel Fernando Ortíz, Angélica Guatibonza H., and Itala Merlano Caropresse. "Manejo quirúrgico del cáncer de piel. Servicio de dermatología, Hospital de San José, Bogotá DC, Colombia." Revista Repertorio de Medicina y Cirugía 22, no. 4 (2013): 293–96. http://dx.doi.org/10.31260/repertmedcir.v22.n4.2013.759.

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Introducción: el cáncer de piel representa un problema de salud pública que se puede prevenir y manejar con éxito ante el diagnóstico temprano. Objetivo: describir las características clínicas, histopatológicas, poblacionales y quirúrgicas del cáncer de piel tratado mediante cirugía en el Hospital de San José de Bogotá DC, de enero 2009 a diciembre 2010. Material y métodos: estudio descriptivo y retrospectivo de dos años de los casos confirmados de carcinoma basocelular, escamocelular y melanoma in situ. Resultados: de 294 historias clínicas revisadas se tomaron cien con diagnóstico de cáncer

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Cornejo, Kristine M., and April C. Deng. "Malignant Melanoma Within Squamous Cell Carcinoma and Basal Cell Carcinoma." American Journal of Dermatopathology 35, no. 2 (2013): 226–34. http://dx.doi.org/10.1097/dad.0b013e3182545e27.

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Morgado-Águila, Carolina, Guadalupe Gil-Fernández, Orlando Rafael Dávila-Villalobos, Jesús Pérez-Rey, Purificación Rey-Sánchez, and Francisco José Rodríguez-Velasco. "Vitamin D serum levels and non-melanoma skin cancer risk." PeerJ 9 (September 24, 2021): e12234. http://dx.doi.org/10.7717/peerj.12234.

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Background Skin cancer is one of the common malignancies. There is sufficient evidence that sunlight (ultraviolet radiation) contributes to the development of skin cancer, but there is also evidence that relates adequate serum levels of vitamin D produced on the skin by the action of ultraviolet radiation with the decreased risk of various types of cancers, including skin cancer. The aim of this study was to investigate the association of vitamin D serum levels among patients with non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma) and controls. Methods A prospective o

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Pereira Maia, Iana Lara, Joaquim José Silva, Hafiza Gonçalves Alexandrino Regino, Khadija Neide Alexandrino Regino, Liana Barbosa e Sila, and Sônia Araújo Rogério Nunes. "Carcinoma de pele no segmento craniofacial: Relato de 3 casos." Journal of Health & Biological Sciences 2, no. 3 (2014): 145. http://dx.doi.org/10.12662/2317-3076jhbs.v2i3.55.p145-148.2014.

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O câncer de pele é a neoplasia mais frequente no Brasil. O tipo histológico mais comum é o carcinoma basocelular (CBC), 70% dos casos, seguido pelo carcinoma espinocelular (CEC) e pelo melanoma. Relatamos três carcinomas de pele no segmento crânio facial, evidenciando as abordagens cirúrgicas realizadas. No caso 1, apresenta-se um CBC em hemiface submetido à exérese com retalho V-Y. No caso 2, destaca-se um CEC em couro cabeludo submetido à exérese com retalhos de rotação e da vizinhança. No caso 3, relata-se um CBC na região pré-auricular e no dorso nasal submetido à exérese com retalho de Li

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Madej, Janusz A. "Neoplastic cannibalism and a suggestion for changes in terminology of selected epithelial tumors." Medycyna Weterynaryjna 74, no. 1 (2018): 6040–2018. http://dx.doi.org/10.21521/mw.6040.

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The types of cell cannibalism (entosis) are described (Fig. 1 and 2), including heterocannibalism and homocannibalism (autocannibalism), in which neoplastic cells can undergo incomplete heterophagocytosis, complete heterophagocytosis, pseudocannibalism, degradation to granular bodies, transformation of benign neoplastic cells into malignant ones, reduction in clonogenic potential or the progression of malignancy of tumour cells. The author also suggests changes in the nomenclature of some epithelial neoplasms, (Fig. 3) including tumours originating from blood vessel and lymphatic endothelium (

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van der Velden, Haike M. J., Michelle M. van Rossum, Willeke A. M. Blokx, Jan B. M. Boezeman, and Marie-Jeanne P. Gerritsen. "Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients." Dermatology Research and Practice 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/479183.

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The increasing number of living cutaneous melanoma patients and the increased risk of developing a second primary tumour incited us to analyse the clinical characteristics of cutaneous melanoma and define the frequency, site, and type of second primary cancers in cutaneous melanoma patients. We collected data on patients who visited the Department of Dermatology at the Radboud University Nijmegen Medical Centre and were newly diagnosed with cutaneous melanoma or metastasis of melanoma with unknown primary localization between 2002 and 2006. A total of 194 cases were included; eleven patients d

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Cives, Mauro, Francesco Mannavola, Lucia Lospalluti, et al. "Non-Melanoma Skin Cancers: Biological and Clinical Features." International Journal of Molecular Sciences 21, no. 15 (2020): 5394. http://dx.doi.org/10.3390/ijms21155394.

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Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have

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Grabowski, Julia, Sidney L. Saltzstein, Georgia Robins Sadler, Zunera Tahir, and Sarah Blair. "A Comparison of Merkel Cell Carcinoma and Melanoma: Results from the California Cancer Registry." Clinical medicine. Oncology 2 (January 2008): CMO.S423. http://dx.doi.org/10.4137/cmo.s423.

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Introduction Melanoma and Merkel cell carcinoma (MCC) are both aggressive skin malignancies associated with immunosuppression and possible UV exposure. Both tumors get similar surgical treatment; however, MCC is a relatively rare tumor in which less is known about prognosis and clinical behavior. Methods The California Cancer Registry (CCR), a population-based registry, was reviewed from the years 1988-2003. Merkel cell carcinoma and melanoma were compared with relation to gender, age, ethnicity, disease stage, site, and survival. Results A total of 113,187 cases of melanoma and 1,878 cases of

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Arya, Payam, Walid E. Khalbuss, Sara E. Monaco, and Liron Pantanowitz. "Salivary duct carcinoma with striking neutrophil-tumor cell cannibalism." CytoJournal 8 (August 24, 2011): 15. http://dx.doi.org/10.4103/1742-6413.84222.

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Cannibalism of neutrophils by tumor cells has previously been reported in certain carcinomas, lymphoma and melanoma. Tumor cannibalism is believed to serve as a tumor-immune escape mechanism, associated with high-grade aggressive cancers with a significantly increased metastatic potential. This interesting phenomenon has not been previously documented in association with salivary gland tumors. We report, for the first time, striking neutrophil-tumor cell cannibalism associated with a high grade, aggressive and metastatic salivary duct carcinoma of the parotid gland highlighted within cytologic

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Piipponen, Minna, Pilvi Riihilä, Liisa Nissinen, and Veli-Matti Kähäri. "The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma." Cancers 13, no. 18 (2021): 4507. http://dx.doi.org/10.3390/cancers13184507.

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Skin cancers are the most common types of cancer worldwide, and their incidence is increasing. Melanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC) are the three major types of skin cancer. Melanoma originates from melanocytes, whereas BCC and cSCC originate from epidermal keratinocytes and are therefore called keratinocyte carcinomas. Chronic exposure to ultraviolet radiation (UVR) is a common risk factor for skin cancers, but they differ with respect to oncogenic mutational profiles and alterations in cellular signaling pathways. cSCC is the most common metastat

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Le, Mina N., Erica Lee, and Bhuvanesh Singh. "The Evolution of Staging of Cutaneous Squamous Cell Carcinomas: A Structured Review." International Journal of Head and Neck Surgery 8, no. 2 (2017): 57–63. http://dx.doi.org/10.5005/jp-journals-10001-1307.

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ABSTRACT Among non-melanoma skin cancers, cutaneous squamous cell carcinoma entails the highest morbidity and mortality, and yet there is little guidance on how to identify the subset of cutaneous squamous cell carcinomas that behave aggressively. The staging of non-melanoma skin cancers is meant to provide this guidance, by dividing patients into groups for which survival differs between groups, is similar within each group, and consistently decreases with each increasing stage group. In the present review, we explore the history of how the staging of non-melanoma skin cancers, focusing on cu

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Pinho, André, Brigite Aguiar, Maria Manuel Brites, Ricardo Vieira, Rui Alves, and Américo Figueiredo. "Sirolimus e Prevenção Primária de Cancro Cutâneo Não-melanoma em Transplantados Renais – Um Estudo Retrospetivo." Journal of the Portuguese Society of Dermatology and Venereology 74, no. 2 (2016): 153–59. http://dx.doi.org/10.29021/spdv.74.2.551.

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Introdução: A imunossupressão desempenha um papel central na patogénese do cancro cutâneo, em transplantados renais. Recentemente tem sido estudado o potencial do sirolimus na redução da incidência de cancro cutâneo não-melanoma nesta população.Objetivo: Analisar a relação entre os esquemas imunossupressores de manutenção iniciais e o desenvolvimento de cancro cutâneo não-melanoma – carcinoma espinhocelular e carcinoma basocelular – em transplantados renais.Métodos: Análise retrospetiva dos registos clínicos de doentes submetidos a transplante renal entre os anos 2002 e 2012 e que vieram poste

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Akslen, Lars A., and Andreas O. Myking. "Balloon Cell Melanoma Mimicking Clear Cell Carcinoma." Pathology - Research and Practice 184, no. 5 (1989): 548–50. http://dx.doi.org/10.1016/s0344-0338(89)80150-5.

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Radhi, J. M. "Urethral malignant melanoma closely mimicking urothelial carcinoma." Journal of Clinical Pathology 50, no. 3 (1997): 250–52. http://dx.doi.org/10.1136/jcp.50.3.250.

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Segal, Robert, Neal S. Penneys, and George Nahass. "Metastatic prostatic carcinoma histologically mimicking malignant melanoma." Journal of Cutaneous Pathology 21, no. 3 (1994): 280–82. http://dx.doi.org/10.1111/j.1600-0560.1994.tb00274.x.

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Kaufman, Howard L. "Vaccines for Melanoma and Renal Cell Carcinoma." Seminars in Oncology 39, no. 3 (2012): 263–75. http://dx.doi.org/10.1053/j.seminoncol.2012.02.011.

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O., Shamai-Lubovitz, Rothem A., Sandbank M., and Hauben D. "CUTANEOUS METASTATIC BREAST CARCINOMA SIMULATING MALIGNANT MELANOMA." American Journal of Dermatopathology 14, no. 1 (1992): 68. http://dx.doi.org/10.1097/00000372-199202000-00033.

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Biernacka, Anna, Konstantinos D. Linos, Peter A. DeLong, Arief A. Suriawinata, Vijayalakshmi Padmanabhan, and Xiaoying Liu. "A case of S-100 negative melanoma: A diagnostic pitfall in the workup of a poorly differentiated metastatic tumor of unknown origin." CytoJournal 13 (September 20, 2016): 21. http://dx.doi.org/10.4103/1742-6413.190914.

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When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology – malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly suggestive of widespread primary lung cancer. This case was eventually classified as malignant melanoma, despite a sig

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Nunez, D. A., C. G. C. Sutherland, and R. K. Sood. "Breast metastasis from a pharyngeal carcinoma." Journal of Laryngology & Otology 103, no. 2 (1989): 227–28. http://dx.doi.org/10.1017/s0022215100108540.

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AbstractThe reported incidence of metastatic disease in head and neck cancer is increasing. The most common site of metastatic involvement in squamous carcinoma of the head and neck is the lung followed by liver, mediastinal nodes and bone. The breast is rarely infiltrated by metastatic disease, 2 per cent or less of clinically detected breast lumps being of nonmammary origin, most frequently malignant melanoma, lymphoma/leukaemia and primary lung carcinoma.A 73-year-old female presented with a primary posterior pharyngeal wall squamous carcinoma and bilateral enlarged neck nodes. She develope

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Morgado-Águila, Carolina, Purificación Rey-Sánchez, Guadalupe Gil-Fernández, María Carmen Costa-Fernández, and Francisco José Rodríguez-Velasco. "Vitamin D Receptor Polymorphisms and Non-Melanoma Skin Cancer Risk: A Case-Control Study." Journal of Clinical Medicine 9, no. 12 (2020): 3819. http://dx.doi.org/10.3390/jcm9123819.

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Exposure to sunlight is the major source of vitamin D and the main environmental cause of non-melanocytic skin cancers. Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. The aim of this study was to investigate the association of BsmI and ApaI VDR polymorphisms among patients with non-melanoma cancers and controls. An observational case-control study was conducted in a sample of 154 subjects. We observed no significant effects between these polymorphisms and skin cancer risk. When stratified for gender, GG and AG BsmI polymo

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