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Journal articles on the topic 'Melanoma, TDG'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Hafner-Marx, Angela, and Wolfram Breuer. "Primäres malignes Melanom im Gehirn eines 7 Monate alten Schafs (Ovis aries f. domestica)." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 45, no. 02 (2017): 108–11. http://dx.doi.org/10.15653/tpg-160585.

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ZusammenfassungVorgestellt wird ein bislang nicht beschriebener Fall eines malignen Melanoms im Gehirn eines Schafs. Ein wegen Ataxie euthanasiertes, erst 7 Monate altes, weibliches Schaf wurde pathologisch-anatomisch und histopathologisch untersucht. Sowohl das Gehirn als auch das Schädeldach waren von einem malignen Melanom infiltriert. Metastasen fanden sich in Leber und Nieren. Auch histomorphologisch zeigte das Melanom die Charakteristika einer malignen Neoplasie. Die kongenitale Ansammlung von Melanozyten in der Hirnhaut des Schafs (kongenitale Melanose) ist eine regelmäßig beobachtete P

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2

Voigt, Katja, Almuth Falkenau, Nadja Herbach, Melanie Feist, and Theresa Tschoner. "Intraokuläres Melanom bei einer 10 Jahre alten Lamastute (Lama glama)." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 46, no. 05 (2018): 334–39. http://dx.doi.org/10.15653/tpg-180093.

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ZusammenfassungEine 10-jährige Lamastute wurde mit einer chronisch wuchernden Masse des linken Auges vorgestellt. Das Tier zeigte einen linksseitigen Exophthalmus, die Nickhaut war gerötet. Die Hornhaut war von einer gelblich-rötlichen, undurchsichtigen Gewebsmasse bedeckt und wies ulzerative Veränderungen auf. Die tieferen Strukturen des Auges ließen sich nicht beurteilen. Das rechte Auge stellte sich unauffällig dar. Das linke Auge wurde unter Allgemeinanästhesie entfernt. Die histopathologische Untersuchung des Exstirpats ergab ein okuläres amelanotisches Melanom. Kornea, Sklera, Glaskörper

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Dizman, Nazli, Iqbal Mahmud, Julie Simon, et al. "Abstract 287: Circulating metabolites associated with response to immune checkpoint blockade in melanoma." Cancer Research 85, no. 8_Supplement_1 (2025): 287. https://doi.org/10.1158/1538-7445.am2025-287.

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Abstract Introduction: Metabolism plays a crucial role in tumor microenvironment dynamics and may influence response to immune checkpoint blockade (ICB). We examined the relationship between the serum metabolomic and lipidomic profiles and outcomes with ICBs in melanoma. Methods: Patients with melanoma initiating standard of care anti-PD1-based ICB therapy with neoadjuvant or palliative intent were prospectively enrolled. Clinical characteristics were abstracted and survival and objective response using RECIST 1.1 were assessed. Patients with complete or partial response were classified as the

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THARPE, Ansley S., Kenneth J. VEGA, and Bruce W. TROTMAN. "Primary anorectal melanoma." Turkish Journal of Gastroenterology 23, no. 6 (2012): 820–21. http://dx.doi.org/10.4318/tjg.2012.0498.

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5

Lecouturier, Jan, Helen Bosomworth, Marie Labus, Rob A. Ellis, and Penny E. Lovat. "Health professional and patient views of a novel prognostic test for melanoma: A theoretically informed qualitative study." PLOS ONE 17, no. 4 (2022): e0265048. http://dx.doi.org/10.1371/journal.pone.0265048.

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Objectives Cutaneous melanoma rates are steadily increasing. Up to 20% of patients diagnosed with AJCC Stage I/II melanomas will develop metastatic disease. To date there are no consistently reliable means to accurately identify truly high versus low-risk patient subpopulations. There is hence an urgent need for more accurate prediction of prognosis to determine appropriate clinical management. Validation of a novel prognostic test based on the immunohistochemical expression of two protein biomarkers in the epidermal microenvironment of primary melanomas was undertaken; loss of these biomarker

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6

Sun, Hongyin, Kui Deng, Xingchen Zhou, et al. "A novel gene prognostic signature lymphocyte cytosolic protein 2 regulates melanoma progression by activating tumor-infiltrating CD8+ T-cells through the interferon regulatory factor 5 signaling pathway." Tumor Discovery 2, no. 1 (2023): 318. http://dx.doi.org/10.36922/td.318.

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Cutaneous malignant melanoma is the most lethal skin cancer. The advent of immunotherapy has revolutionized the status of clinical therapies of melanoma, which brought new hope to these patients. However, only a small proportion of patients are responders. Therefore, the identification of novel prognostic and immune-related biomarkers is crucial to guide the development of melanoma clinical treatments. Herein, RNA-seq data of the cutaneous melanoma from public database were used for identifying prognostic gene signatures, and we found that lymphocyte cytosolic protein 2 (LCP2) was highly expre

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Titov, K. S., D. L. Rotin, A. M. Kazakov, O. U. Micheeva, I. M. Telezhnikova, and D. A. Ryabchikov. "Expression rate of ALK tyrosine kinase and TAG-72 oncoprotein in primary skin melanoma." Russian Journal of Biotherapy 17, no. 3 (2018): 50–54. http://dx.doi.org/10.17650/1726-9784-2018-17-3-50-54.

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Objective.Determine the frequency of occurrence of tyrosine kinase expression of the mutated ALK and TAG-72 gene among patients with primary melanoma of the skin, to identify their association with a number of histological parameters, and to assess the diagnostic value of the determination of ALK and TAG-72.Materials and methods.Paraffin blocks with surgical material from 40 patients with primary skin melanoma. For routine histological examination, the material was fixed with 10 % neutral formalin for 24 h, poured into paraffin, sections were prepared with a thickness of 4–5 μm, stained with h

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Malindi, Zaria, Stefan Barth, and Heidi Abrahamse. "The Potential of Antibody Technology and Silver Nanoparticles for Enhancing Photodynamic Therapy for Melanoma." Biomedicines 10, no. 9 (2022): 2158. http://dx.doi.org/10.3390/biomedicines10092158.

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Melanoma is highly aggressive and is known to be efficient at resisting drug-induced apoptotic signals. Resection is currently the gold standard for melanoma management, but it only offers local control of the early stage of the disease. Metastatic melanoma is prone to recurrence, and has a poor prognosis and treatment response. Thus, the need for advanced theranostic alternatives is evident. Photodynamic therapy has been increasingly studied for melanoma treatment; however, it relies on passive drug accumulation, leading to off-target effects. Nanoparticles enhance drug biodistribution, uptak

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9

Foureau, David, Kendall Carpenter, Asim Amin, Fei Guo, Richard White, and Jonathan Salo. "Myeloid-conditioning using Toll-like receptor agonists to restore immune potency against melanoma. (TUM4P.926)." Journal of Immunology 192, no. 1_Supplement (2014): 138.27. http://dx.doi.org/10.4049/jimmunol.192.supp.138.27.

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Abstract Suppressor cells of myeloid origin contribute to the immune imbalance observed in advanced melanoma. Toll-Like Receptor (TLR) signaling regulates myeloid differentiation and maturation. This study sought to determine the distribution of myeloid suppressor cell subsets in B16F10 melanoma-bearing mice, and modulate their immunosuppressive phenotype by employing a regimen of intracellular TLR agonist(s). Tolerogenic dendritic cells (tDC) and granulocytic myeloid-derived suppressor cells (gMDSC) are primarily observed in the periphery (spleen, PBMC, draining lymph node) of B16F10-bearing

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10

Duffy, David, Rick Sturm, Gu Zhu, and Stuart MacGregor. "Gene Discovery Using Twins." Twin Research and Human Genetics 23, no. 2 (2020): 90–93. http://dx.doi.org/10.1017/thg.2020.38.

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AbstractOne of Nick’s key early achievements at QIMR was to establish a twin study on melanoma risk factors. The Brisbane Twin Nevus Study (BTNS) had an initial focus on nevus (mole) count in adolescents but, reflecting Nick’s broad interests, expanded in scope enormously over the decades. In the skin cancer arena, BTNS was essential to genetic discoveries in melanoma, eye color and pigmentation. Later studies amassed data on thousands of phenotypes, ranging from molecular phenotypes such as gene expression to studies where gene mapping findings in adolescents turned out to have translational

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11

Karakök Güngör, Hilayda, and Bengü Nisa Akay. "Current Treatment Modalities in Advanced Melanoma." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 10, no. 4 (2016): 137–44. http://dx.doi.org/10.4274/tdd.3103.

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12

Arican, Ozer, and Irem Erturk. "A Case of Melanoma Associated Leukoderma." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 4, no. 2 (2010): 52–54. http://dx.doi.org/10.5152/tdd.2010.05.

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13

YENIOVA, Ozgur, Akif ALTINBAS, Osman ERSOY, Musa AYDINLI, and Yusuf BAYRAKTAR. "Metastatic liver malignant melanoma of unknown origin." Turkish Journal of Gastroenterology 23, no. 4 (2012): 420–21. http://dx.doi.org/10.4318/tjg.2012.0375.

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14

Aoude, Lauren G., Michael Gartside, Peter Johansson, et al. "Prevalence of Germline BAP1, CDKN2A, and CDK4 Mutations in an Australian Population-Based Sample of Cutaneous Melanoma Cases." Twin Research and Human Genetics 18, no. 2 (2015): 126–33. http://dx.doi.org/10.1017/thg.2015.12.

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Mutations in Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) and Cyclin-Dependent Kinase 4 (CDK4) contribute to susceptibility in approximately 40% of high-density cutaneous melanoma (CMM) families and about 2% of unselected CMM cases. BRCA-1 associated protein-1 (BAP1) has been more recently shown to predispose to CMM and uveal melanoma (UMM) in some families; however, its contribution to CMM development in the general population is unreported. We sought to determine the contribution of these genes to CMM susceptibility in a population-based sample of cases from Australia. We genotyped 1,109 pr

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15

Wiraja, Christian, David C. Yeo, and Chenjie Xu. "Framework Nucleic Acids: A Paradigm Shift in Transdermal Drug Delivery." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 5 (2019): 531–32. http://dx.doi.org/10.1177/2472630319848679.

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Transdermal drug delivery (TDD) provides a direct drug administration route bypassing gastrointestinal and liver metabolism. Until now, topical nanocarriers responsible for efficient TDD are predominantly polymeric or lipid based. The size-dependent skin penetration ability of framework nucleic acids (FNAs) has recently been reported, along with their efficacy in delivering doxorubicin for skin melanoma therapy. This commentary is to highlight the paradigm shift of nucleic acid delivery from being a cargo moiety to serving as a drug carrier instead. Further development directions to maximize t

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16

Baykal, Can, and Algün Polat Ekinci. "Malign Melanoma: Risk Factors and Major Clinical Findings." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 9, no. 1 (2015): 1–7. http://dx.doi.org/10.4274/tdd.2671.

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17

SERIN, Gurdeniz, Basak DOGANAVSARGIL, Cemil CALISKAN, Taner AKALIN, Murat SEZAK, and Muge TUNCYUREK. "Colonic malignant melanoma, primary or metastatic? Case report." Turkish Journal of Gastroenterology 21, no. 1 (2010): 45–49. http://dx.doi.org/10.4318/tjg.2010.0048.

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18

Buhazi, Ioana Mădălina, Ioana-Georgeta Grosu, Xenia Filip, et al. "Polydopamine conjugated SiO₂ nanoparticles as potential drug carriers for melanoma treatment." Therapeutic Delivery 14, no. 2 (2023): 157–73. http://dx.doi.org/10.4155/tde-2023-0010.

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Silica nanoparticles (SiO2) are increasingly investigated for biomedical applications. Aim: This study aimed to analyze the potential use of a SiO2 nanoparticles coated with biocompatible polydopamine (SiO2@PDA) as a potential chemotherapeutic drug carrier. Materials & methods: SiO2 morphology and PDA adhesion was analyzed by dynamic light scattering, electron microscopy and nuclear magnetic resonance. Cytotoxicity studies and morphology analyses (immunofluorescence, scanning and transmission electron microscopy) were used to assess the cellular reaction to the SiO2@PDA nanoparticles and t

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19

Platt, Sarah, Ewan Wilson, Joya Pawade, Axel Walther, and Claire Newton. "Review of gynaecological malignant melanomas." Obstetrician & Gynaecologist 22, no. 3 (2020): 199–207. http://dx.doi.org/10.1111/tog.12666.

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20

Başak, Pınar, and Rainer Hofmann-Wellenhof. "Atipik Dermatofibroma Benzeri Dermoskopik Bulgular Gösteren Bir Melanoma Olgusu." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 8, no. 2 (2014): 121–22. http://dx.doi.org/10.4274/tdd.1879.

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21

Cubukcu, Erdem, Omer Fatih Olmez, Kanat Ozkan, et al. "Malignant melanoma of the stomach in an elderly patient." Turkish Journal of Gastroenterology 25, no. 1 (2015): 295–96. http://dx.doi.org/10.5152/tjg.2014.3845.

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22

Fang, Shenying, Jiachun Lu, Xinke Zhou, et al. "Functional annotation of melanoma risk loci identifies novel susceptibility genes." Carcinogenesis 41, no. 4 (2019): 452–57. http://dx.doi.org/10.1093/carcin/bgz173.

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Abstract Genome-wide association study (GWAS)-identified single-nucleotide polymorphisms (SNPs) are tag SNPs located in both transcribed and non-coding regulatory DNA regions, rather than representing causal or functional variants for disease. To identify functional variants or genes for melanoma susceptibility, we used functional mapping and annotation (FUMA) to perform functional annotation of the summary statistics of 2541 significant melanoma risk SNPs (P &lt; 5 × 10−8) identified by GWAS. The original GWAS melanoma study included 15 990 cases and 26 409 controls, representing the larg

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23

Bois, Haley du, Annie L. Chen, Katherine S. Ventre, Maria S. Steele, Triantafyllia Karakousi, and Amanda W. Lund. "Abstract 3511: Melanoma-shed, lymph-borne CSPG4 conditions the pre-metastatic lymph node niche." Cancer Research 83, no. 7_Supplement (2023): 3511. http://dx.doi.org/10.1158/1538-7445.am2023-3511.

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Abstract Tissues are primed for metastasis prior to the arrival of tumor cells. Primary tumors drive this transformation by shedding tumor-derived factors (TDFs), including extracellular vesicles and secreted/shed proteins (TSPs) into tumor-associated blood and lymphatic vasculature. Despite being the most common site of metastasis across solid tumor types, we know very little about how the lymph node (LN) is primed for metastasis by TDFs. Here, we test the hypothesis that lymph-borne TDFs are sufficient to initiate the formation of the pre-metastatic LN niche. Using a murine melanoma model (Y

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24

Davila, Eduardo, Degui Geng, Ratika Srivastava, Adam Riker, and Svetomir Markovic. "Amplifying TLR-MyD88 signals within tumor-specific T-cells enhances antitumor activity to low concentrations of subdominant tumor-antigens (101.35)." Journal of Immunology 184, no. 1_Supplement (2010): 101.35. http://dx.doi.org/10.4049/jimmunol.184.supp.101.35.

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Abstract There is a dire need to understand the cellular signals that can potentiate T-cell responses to weakly immunogenic tumor antigens (TAg) and to tumors expressing suboptimal levels of these antigens. We examined the anti-tumor activity and survival of TLR2-MyD88-stimulated tumor-specific CD8 T-cells derived from melanoma patients and TAg-specific T-cell receptor transgenic pmel mice. TLR2 engagement on pmel CD8 T-cells, but not on TLR2-/-pmel or MyD88-/-pmel T-cells, reduced the activation threshold to a subdominant TAg, resulting in increased production of effector molecules and cytoto

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25

Çiloğlu, Sinem, Alpay Duran, Ahmet Yiğit, Hasan Büyükdoğan, and Ekrem Keskin. "Non-Melanoma Skin Cancers of Pinna: Retrospective Assesment of 51 Cases." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 9, no. 4 (2015): 177–80. http://dx.doi.org/10.4274/tdd.2584.

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26

DOGAN, Mutlu, Suleyman OZDEMIR, Ethem GECIM, Esra ERDEN, and Fikri ICLI. "Intestinal malignant melanoma presenting with small bowel invagination: A case report." Turkish Journal of Gastroenterology 21, no. 4 (2010): 439–42. http://dx.doi.org/10.4318/tjg.2010.0133.

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27

Jandova, Jana, and Georg T. Wondrak. "Abstract 1547: Melanotransferrin (MELTF, CD228) as a determinant of melanomagenesis: MELTF expression attenuates melanoma progression in the A375-luc2 murine metastasis model and human patients." Cancer Research 84, no. 6_Supplement (2024): 1547. http://dx.doi.org/10.1158/1538-7445.am2024-1547.

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Abstract The cell-surface glycoprotein melanotransferrin (MELTF, CD228) is a member of the iron-binding transferrin superfamily expressed in human melanocytes and other cell types. Dysregulated MELTF expression in malignant melanoma has been reported before but its specific role in tumorigenesis has remained elusive. Following our interest in the role of the transferrin receptor (TFRC) in melanomagenesis, our initial TCGA-analysis suggested that high MELTF expression is associated with increased melanoma patient survival. In order to explore the mechanistic role of MELTF in melanoma we perform

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Mecozzi, Nicol, Olga Vera, and Florian Karreth. "Abstract 3743: circPMS1 is a pro-metastatic circular RNA in melanoma." Cancer Research 83, no. 7_Supplement (2023): 3743. http://dx.doi.org/10.1158/1538-7445.am2023-3743.

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Abstract Deregulated gene expression is a major driver of melanoma metastasis, a process that results in the majority of melanoma-related deaths. Importantly, these alterations are not limited to protein-coding mRNAs, but also include noncoding RNAs. Despite many recent studies implicating circular RNAs (circRNAs) in cancer development, it is unknown if their deregulation contributes to melanoma metastasis. To identify circRNAs with putative roles in melanomagenesis, we performed RNA sequencing on a panel of melanoma and melanocyte cell lines. 21 differentially expressed circRNAs were validate

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29

Aedo-Lopez, Veronica. "Abstract A120: Single-Cell RNA Sequencing Combined with Lineage Tracing Identify Clonal Populations Across Melanoma Organ-Specific Metastasis." Cancer Immunology Research 13, no. 2_Supplement (2025): A120. https://doi.org/10.1158/2326-6074.io2025-a120.

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Abstract Melanoma, a highly metastatic skin cancer, exhibits variations in prognosis and response to therapy based on the site of metastasis. Despite the success of immunotherapy and targeted therapies in melanoma, over half of metastatic melanoma patients will experience disease progression due to therapy resistance. The heterogeneity and plasticity of melanoma cells contribute to metastatic dissemination and therapy resistance. We aim to determine whether distinct clones and/or their transcriptional cell states can predict the formation of tumours in various organs. Lineage tracing and clona

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30

Manga, P., J. D. Goldberg, I. Belitskaya-Levy, et al. "Developing genetic markers for melanoma risk assessment." Journal of Clinical Oncology 27, no. 15_suppl (2009): 9046. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.9046.

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9046 Background: Risk assessment for melanoma is currently based on phenotype, family and exposure history. This approach is subject to recall bias and excludes at-risk groups such as those with darker skin pigmentation. Poorly stratified risk pools also result in unnecessary dermatologist visits and biopsies for those at lower risk. Use of genetic markers may improve risk assessment; however few susceptibility markers have been developed to date. There have been a number of reports of association between melanoma and genetic markers though few have been replicated or validated. In addition, t

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31

Suzuki, Kaori, Keiko Akimoto, Nobutaka Fujisawa, et al. "A metastatic melanoma of the small intestine diagnosed by single-balloon enteroscopy." Turkish Journal of Gastroenterology 25, no. 1 (2015): 262–63. http://dx.doi.org/10.5152/tjg.2014.4113.

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32

Geng, Degui, Ratika Srivastava, Chaoyang Li, and Eduardo Davila. "Tumor-targeted T cells secreting TLR5 ligand effectively treat melanoma-bearing mice (127.34)." Journal of Immunology 188, no. 1_Supplement (2012): 127.34. http://dx.doi.org/10.4049/jimmunol.188.supp.127.34.

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Abstract T-cell-based therapies can kill tumor cells expressing immunodominant tumor antigens (TAg). However, this process allows the escape and metastases of tumor cells expressing low levels of TAg or expressing subdominant TAgs. Our preliminary data and published reports indicate that stimulating TLR2 or TLR5 directly on tumor-reactive T-cells reduces the activation threshold to poorly immunogenic TAgs. Genetically engineering T-cells expressing the MART-1 TCR and producing the TLR5 ligand flagellin (Fg) will generate potent and long-lived antitumor activity by costimulating T-cells and ant

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33

GLIGORIJEVIC, Jasmina, Vesna ZIVKOVIC, Biljana DJORDJEVIC, and Irena DIMOV. "Primary gallbladder melanoma in dysplastic nevus syndrome: Report of case and literature review." Turkish Journal of Gastroenterology 22, no. 6 (2011): 626–30. http://dx.doi.org/10.4318/tjg.2011.0278.

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34

Lymberopoulos, Eva, Jie Min Lam, Amanda Stafford, et al. "Decoding tumour bacterial ecosystems: Topological data analysis of bacterial association with immunogenicity." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10563. https://doi.org/10.1200/jco.2025.43.16_suppl.10563.

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10563 Background: The tumour microbiome is increasingly recognised as a key contributor to cancer progression and clinical outcomes, as highlighted in recent iterations of the Hallmarks of Cancer. Translating microbial signatures into actionable insights is hampered by a reliance on dimensionality reduction and a limited capacity to dissect non-linear relationships, leading to incomplete and inconsistent findings. Topological Data Analysis (TDA) is an unsupervised machine learning method that overcomes these limitations by preserving the complexity of high-dimensional data. Here, we applied TD

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35

Akar, Tarik. "An interesting case of anal melanoma caused liver metastases due to misdiagnosed as hemorrhoids." Turkish Journal of Gastroenterology 29, no. 5 (2018): 619–20. http://dx.doi.org/10.5152/tjg.2018.18201.

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36

Singh, Anand, Veena Kochat, Emre Arslan, et al. "Abstract 7547: Enhancers as targets for improvements in immunotherapy." Cancer Research 84, no. 6_Supplement (2024): 7547. http://dx.doi.org/10.1158/1538-7445.am2024-7547.

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Abstract Role of epigenetic elements in mediating tumor immune interaction remains poorly understood. We previously identified enrichment of active enhancer states on a set of genomic loci in non-responders to immune checkpoint blockade (ICB) therapy. We noted that the activated non-responder enhancers marked a group of key regulators of in melanoma cells that are known to mediate resistance to ICB therapy and several checkpoint receptors in T cells. Through spatial epigenomics (Spatial ATAC and CUT&Tag) approaches, we identified the tumor-immune niches harboring unique gene regulatory ele

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37

Das, H. S., C. Panda, and S. Padhi. "Endoscopic diagnosis of a case of malignant melanoma." Tropical Gastroenterology 33, no. 4 (2012): 296–97. http://dx.doi.org/10.7869/tg.2012.78.

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38

Nangia, Varuna, Humza Ashraf, Nasreen Marikar, et al. "Abstract 6418: Non-genetic drug adaptation to MAPK pathway inhibitors in melanoma." Cancer Research 85, no. 8_Supplement_1 (2025): 6418. https://doi.org/10.1158/1538-7445.am2025-6418.

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Abstract Over 50% of melanomas are driven by BRAFV600 mutations. Clinically, targeted inhibitors of mutant BRAF and MEK are the primary treatment for more than 50% of melanoma patients that are refractory to standard-of-care immunotherapy. While targeted therapies are initially clinically effective, a subset of residual cancer cells persist and inevitably drive tumor recurrence and drug resistance. While some cells persist due to pre-existing mechanisms (e.g. genetic mutations), others can non-genetically adapt to tolerate drug by rewiring their internal signaling cascades. Importantly, a key

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39

ONAK KANDEMIR, Nilufer, Burak BAHADIR, Sibel BEKTAS, et al. "Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: Two case reports." Turkish Journal of Gastroenterology 22, no. 1 (2011): 77–82. http://dx.doi.org/10.4318/tjg.2011.0161.

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40

Silva, Catarina Oliveira, Jesús Molpeceres, Belén Batanero, et al. "Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy." Therapeutic Delivery 7, no. 8 (2016): 521–44. http://dx.doi.org/10.4155/tde-2016-0027.

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41

Aedo Lopez, Veronica L., Reem Saleh, Benjamin Blyth, et al. "Abstract B001: Intra- and inter-tumoral heterogeneity of melanoma across different metastatic sites." Cancer Research 84, no. 22_Supplement (2024): B001. http://dx.doi.org/10.1158/1538-7445.tumbody-b001.

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Abstract Melanoma, a highly metastatic skin cancer, exhibits variations in prognosis and response to therapy based on the site of metastasis. Despite the success of immunotherapy and targeted therapies in melanoma, over half of metastatic melanoma patients will experience disease progression due to therapy resistance. The heterogeneity and plasticity of melanoma cells contribute to metastatic dissemination and therapy resistance. Our aim is to determine whether distinct clones and/or their transcriptional cell states can predict the formation of tumors in various organs and assess how these cl

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42

Gülseren, Duygu, Gonca Elçin, Tülin Akan, Nilgün Karabıçak, and Gül Erkin. "A case of Candida parapsilosis Which is Similar to Subungual Malignant Melanoma Clinically and Similar to Glomus Tumor Radiologically." Turkish Journal of Dermatology / Türk Dermatoloji Dergisi 12, no. 1 (2018): 65–67. http://dx.doi.org/10.4274/tdd.3003.

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43

Elsner, Prof Dr med P., and Dr med Steven Goetze. "22. Dermatoonkologischer Tag: Adjuvante Therapie des Malignen Melanoms – 3. November 2018, Jena." Dermatologie in Beruf und Umwelt 66, no. 10 (2018): 194–97. http://dx.doi.org/10.5414/dbx00332.

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44

Saleh, Reem, Riyaben Patel, Dane Vassiliadis, et al. "Abstract C044: Single cell RNA-sequencing coupled with lineage tracing identifies novel clonal populations associated with immunotherapy resistance." Cancer Research 84, no. 22_Supplement (2024): C044. http://dx.doi.org/10.1158/1538-7445.tumbody-c044.

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Abstract Although immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment, many individuals either show no response or eventually develop acquired resistance. This variability could be linked to differences in the tumor immune microenvironment, pre-existing drug-resistant cells or treatment induced changes in melanoma cell states. Using single cell RNA sequencing (scRNA-seq) coupled with heritable barcodes, this study aims to lineage trace changes in melanoma transcriptional cell states and map changes in the tumor immune microenvironment to uncover if preexisting and/or the

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Kayaş, Yavuz, Ferhan Sağın, Yasemin Akçay, et al. "Serum Amyloid A and Lipoprotein Associated Phospholipase A2 Levels in Patients with Malign Melanoma: Correlations with Clinical Assessment and Stage." Turkish Journal of Dermatology 12, no. 3 (2018): 135–42. http://dx.doi.org/10.4274/tdd.3643.

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Cozen, Wendy, Amie E. Hwang, Myles G. Cockburn, Ann S. Hamilton, John Zadnick, and Thomas M. Mack. "The USC Adult Twin Cohorts: International Twin Study and California Twin Program." Twin Research and Human Genetics 16, no. 1 (2012): 366–70. http://dx.doi.org/10.1017/thg.2012.134.

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The study of twin subjects permits the documentation of crude heritability and may promote the identification of specific causal alleles. We believe that at the current time, the chief research advantage of twins as subjects, especially monozygotic twins, is that the commonality of their genetic and cultural identity simplifies the interpretation of biological associations. In order to study genetic and environmental determinants of cancer and chronic diseases, we developed two twin registries, maintained at the University of Southern California: The International Twin Study (ITS) and the Cali

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Siudak, Krystyna, Lena Stallenberger, Christiane Herden, and Julia Vienenkötter. "Renal neoplasia in horses – a retrospective study." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 45, no. 05 (2017): 290–95. http://dx.doi.org/10.15653/tpg-161091.

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SummaryObjective: Being confronted with a case series of renal neoplasia in several horses which was in striking divergence to literature data, we recognized the need of a retrospective study to assess the presence of renal neoplasms in horses. Material and methods: Anamnestic animal data, necropsy findings and results of histological and immuno histochemical examinations from 2010 through 2015 were collected and evaluated regarding renal neoplasia. Results: Data from postmortem examinations of 1069 horses revealed 20 horses with renal tumors constituting a prevalence of 1.87 %. Primary renal

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Yasumoto, K., K. Yokoyama, K. Shibata, Y. Tomita, and S. Shibahara. "Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene." Molecular and Cellular Biology 14, no. 12 (1994): 8058–70. http://dx.doi.org/10.1128/mcb.14.12.8058-8070.1994.

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Tyrosinase is a rate-limiting enzyme in melanin biosynthesis and is specifically expressed in differentiated melanocytes. We have identified the enhancer element in the 5'-flanking region of the human tyrosinase gene that is responsible for its pigment cell-specific transcription and have termed it tyrosinase distal element (TDE) (positions -1861 to -1842). Transient expression assays showed that TDE confers efficient expression of a firefly luciferase reporter gene linked to the tyrosinase gene promoter in MeWo pigmented melanoma cells but not in HeLa cells, which do not express tyrosinase. T

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Yasumoto, K., K. Yokoyama, K. Shibata, Y. Tomita, and S. Shibahara. "Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene." Molecular and Cellular Biology 14, no. 12 (1994): 8058–70. http://dx.doi.org/10.1128/mcb.14.12.8058.

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Tyrosinase is a rate-limiting enzyme in melanin biosynthesis and is specifically expressed in differentiated melanocytes. We have identified the enhancer element in the 5'-flanking region of the human tyrosinase gene that is responsible for its pigment cell-specific transcription and have termed it tyrosinase distal element (TDE) (positions -1861 to -1842). Transient expression assays showed that TDE confers efficient expression of a firefly luciferase reporter gene linked to the tyrosinase gene promoter in MeWo pigmented melanoma cells but not in HeLa cells, which do not express tyrosinase. T

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Ferrari de Andrade, Lucas, Rong En Tay, Deng Pan, et al. "Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity." Science 359, no. 6383 (2018): 1537–42. http://dx.doi.org/10.1126/science.aao0505.

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MICA and MICB are expressed by many human cancers as a result of cellular stress, and can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D (NKG2D) receptor activation. However, tumors evade this immune recognition pathway through proteolytic shedding of MICA and MICB proteins. We rationally designed antibodies targeting the MICA α3 domain, the site of proteolytic shedding, and found that these antibodies prevented loss of cell surface MICA and MICB by human cancer cells. These antibodies inhibited tumor growth in multiple fully immunocompetent mouse models and

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