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Pangondian Harahap, Aswan, Robiatun Rambe, Ratih Paramitha, and Yulanda Yulanda. "Standarisasi Dan Perbandingan Uji Aktivitas Antioksidan Dari Ekstrak Etanol Dan Dekok Daun Senggani ( Melastoma malabathricum L.) Dengan Menggunakan metode DPPH." FORTE JOURNAL 2, no. 1 (2022): 11–21. http://dx.doi.org/10.51771/fj.v2i1.191.
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ABSTRAK
 Senggani (Melastoma malabathricum L.) memiliki kandungan kimia seperti alkaloid, flavonid, tanin, saponin dan steroid . Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.) serta perbandingan nilai IC50 dari ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.). Metode Ekstraksi yang digunakan dalam penelitian ini adalah maserasi dengan pelarut etanol 70% . dan dekok dengan pelarut air pada suhu 90o selama 30 menit.Pengujian aktivutas antioksidan menggunakan metode peredaman radikak bebas DPPH. Hasil ekstraksi daun senggani menggunakan pelarut etanol 70% menghasilkan ekstrak cair kemudian di kentalkan menghasilkan ekstrak kental sebanyak 110,2 gram dengan persen rendemen sebesar 22,04 %. Dekok daun senggani menggunakan pelarut air menghasilkan 49,90 gram dengan rendemen ekstraksebesar 24,95% . Dari Hasil pengukuran aktivitas antioksidan diperoleh nilai IC50 ekstrak etanol daun senggani (Melastoma malabathricum L.) sebesar 19,206 ppm, dan dekok daun senggani (Melastoma malabathricum L.) sebesar17,140 ppm. Kesimpulan bahwa Aktivitas antioksidan dari Ekstrak Etanol dan Dekok daun senggani (Melastoma malabathricum L.) diperoleh melalui metode pengujian dengan DPPH dengan nilai IC50 ekstraketanol daun senggani sebesar 19,206 ppm dan dekok daun senggani sebesar17.140 ppm dimana aktivitas antioksidan tergolong sangat kuat, kedua sempel memiliki aktivitas antioksidan yang sangat kuat tetapi Nilai IC50 Dekok daun Senggani (Melastoma malabathricum L.) lebih baik dibanding kan ekstrak Etanol Daun Senggani (Melastoma malabathricum L.).
 
 
 Kata Kunci : Melastoma malabathricum L, aktivitas antioksidan, metode DPPH.
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Suryani, Lilis. "Biologi Reproduksi dan Polinasi Buatan Tumbuhan Senduduk (Melastoma malabathricum L.)." BIOSITE |BIOLOGI Sains Terapan 3, no. 2 (2018): 47–53. http://dx.doi.org/10.22437/bs.v3i2.4775.
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Abstract
 Melastoma malabthricum is the type with the widest area of spread compared with other species in the genus Melastoma. This research uses floral phenology observation method and pollination experiment by using bagging technique, emasculation and artificial pollination. Stigma receptivity was tested according to the Matson method. The results showed that M. malabathricum’s flowers take 14 until 21 days from bud to flower bloom. Stigma M. malabathricum is already present and receptive before anthesis flower. Fruit can be formed through self pollination (autogamy) and cross pollination (xenogamy). M. malabathricum pollination approaches the xenogamy facultative.
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Dongoran, Rini Fitriani, Elmi Sariani Hasibuan, and Ayus Diningsih. "Isolasi Senyawa Antimikroba Pada Daun Senduduk (Melastoama malabathricum L. )." Jurnal Kesehatan Ilmiah Indonesia (Indonesian Health Scientific Journal) 8, no. 1 (2023): 101–5. http://dx.doi.org/10.51933/health.v8i1.1033.
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ABSTRACT Background: Senduduk leaves (Melastoma malabathricum L.) are plants from the Melastomaceae family, contains steroids which can provide antimicrobial activity based on the results of the KLT-Bioautography test. Objective: To determine the activity of senduduk leaf extract (Melastoma malabathricum L.) to several test microbes and to find out the chemical components of senduduk leaf extract (Melastoma malabathricum L.) which provides antimicrobial activity. Method: The extract of senduduk leaves which have been fractionated with n-hexane and ethyl acetate, then tested the antimicrobial activity by using paper foil to determine a better fractionate result, after which the antimicrobial fraction was carried out by antimicrobial testing by KLT- bioautography. Result : there is a clear zone on the media that has been bottled by ethyl acetate fraction on Staphylococcus aureus, Escherichia coli, and Candida albicans. Conclusion: The results of this study concluded that the antimicrobial activity of the senduduk ethyl acetate leaf fraction (Melastoma malabathricum L.) was carried out by the KLT-bioautography test, where the compounds that gave antimicrobial activity were thought to be flavonoids, tannins, saponins, glycosides and alkaloids. Keywords : Antimicrobial, senduduk leaf extract, KLT- bioautograph ABSTRAK Latar Belakang: Daun senduduk (Melastoma malabathricum L.) merupakan tanaman dari famili Melastomaceae, mengandung senyawa flavonoid, tannin, glikosida, dan alkaloid yang dapat memberikan aktivitas antimikroba berdasarkan hasil uji secara Klt- Bioautografi. Tujuan: Mengetahui aktivitas ekstrak daun senduduk (Melastoma malabathricum L.) yang telah difraksi kemudian diuji terhadap beberapa mikroba uji dan untuk mengetahui kandungan kimia ekstrak daun senduduk (Melastoma malabathricum L.) yang memberikan aktivitas antimikroba. Metode: Ekstrak daun senduduk (Melastoma malabathricum L.) yang telah difraksinasi dengan n-heksan dan etil asetat, kemudian di uji aktivitas antimikrobanya dengan kertas pencadang untuk menentukan hasil fraksinat yang lebih baik, setelah itu hasil fraksi etil asetat dilakukan uji antimikroba secara KLT bioautografi. Hasil: Terdapat zona bening pada media yang telah ditotol oleh fraksi etil asetat pada Staphylococcus aureus, Eschericia coli, dan Candida albicans. Kesimpulan: Hasil penelitian dapat disimpulkan bahwa aktivitas antimikroba terhadap fraksi etil asetat daun senduduk (Melastoma malabathricum L.) dilakukan dengan uji KLT-bioautografi, dimana senyawa yang memberikan aktivitas antimikroba diduga adalah golongan flavonoid, tannin, saponin, glikosida, dan alkaloid. Kata kunci : Antimikroba, daun senduduk, KLT-bioautografi
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Noviyanty, Yuska, Hepiyansori Hepiyansori, and Berliana Rosita Dewi. "Identifikasi dan Penetapan Kadar Senyawa Saponin Ekstrak Etanol Bunga Senggani (Melastoma malabathricum L) Metode Gravimetri." Oceana Biomedicina Journal 3, no. 1 (2020): 45. http://dx.doi.org/10.30649/obj.v3i1.46.
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<p>Traditional medicine is an ancestral cultural heritage derived from natural materials and to this day continue to be used by the general public. One of the plants that can be used as a traditional medicine is a plant Senggani (Melastoma malabathricum L). The purpose of this study was to determine the saponins contained from flower extracts Senggani (Melastoma malabathricum L) and percent saponin levels of Senggani flower extract (Melastoma malabathricum L).</p><p>Extraction is done by maceration using ethanol 96% for 5 days. Extraction obtained is then concentrated by means of a rotary evaporator. The results were qualitative identification of the foam test and color test and quantitative assay with gravimetric method.</p><p>Based on research conducted Senggani ethanol extracts of flowers (Melastoma malabathricum L) contains saponins types of triterpenoids seen from the ring in maroon and obtained the average level of interest saponin Senggani (Melastoma malabathricum L) is 11.46%.</p><strong>Keywords: Flowers Senggani, saponin, Gravimetry</strong>
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Suryani, Lilis, and Fitria Ramona. "Pollen morphological ultrastructure of Melastoma L. (Melastomataceae)." Jurnal Biologi UNAND 8, no. 1 (2020): 9. http://dx.doi.org/10.25077/jbioua.8.1.9-13.2020.
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Melastoma L. is a type genus of Melastomataceae. Melastoma malabthricum is the type with the widest area of spread compared with other species in the genus Melastoma. This research aim to study pollen morphological ultrastructure of Melastoma. Research carried out with collecting species which include to Melastoma with survey methode. Pollen morphological ultrastructure observation used Scanning Electron Microscope Type JSM-IT-200. Pollen sample obtained from the flowers collection where not yet anthesis. In Laboratory polen was fixation, dehidration and coating then observed with electrone microscope to taken pollen photo and identification. Two species are prolate spheroidal that are M. malabathricum dan M. tebauchina. Four species are oblate spheroidal that are M. setigerum, M. baccarianum, M.minahasae dan M. malabathricum var. malabathricum. The results scanning electron microscope from six species Melastoma seen only have aperture like a gap called colpus with amount variation. Pollen ornamentation on six species Melastoma looks like striate type.
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Pratiwi, Liza, Rafika Sari, and Pratiwi Apridamayanti. "Synergistic Interaction of Ethyl Acetate Fraction of Melastoma malabathricum L. Leaves Combined with Ciprofloxacin and Gentamicin Against Eschericia coli Isolate for Diabetic Foot Ulcer Patients." Majalah Obat Tradisional 26, no. 1 (2021): 63. http://dx.doi.org/10.22146/mot.57399.
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Melastoma malabathricum leaves have active compounds that are thought to have the potential as antibacterial namely flavonoids, phenols and terpenoids. The objective of this study was to find effective drugs formulated from Melastoma malabathricum leaves combined with antibiotics as diabetic foot ulcer therapy to prevent further complications and risk of disability in diabetes mellitus patients. Ciprofloxacin and gentamicin were proven to be resistant antibiotics. In this study, the fraction of Melastoma malabathricum leaves was combined with both types of antibiotics namely ciprofloxacin and gentamicin. The minimum inhibitory concentration (MIC) has been determined against bacterial strains. The determination of MIC (Minimum Inhibitory Concentration) value was done using the Kirby-Bauer disk diffusion method. The interaction of antibiotics with gentamicin and ciprofloxacin was studied in vitro by calculating fractional inhibitory concentration index (FICI). The synergistic effects of the combination Melastoma malabathricum fraction and antibiotics were observed. The results showed that the combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin against Escherichia coli had a synergistic effect with FICI value of 0,5. The combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin have the synergistic effect inhibiting the Escherichia coli.
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Hamdani, Nina, Rachmat Kosman, and Rusli Rusli. "UJI AKTIVITAS ANTIBAKTERI FUNGI ENDOFIT PADA DAUN SENGGANI (Melastoma malabathricum L.) ASAL LAMPARA MONCONGLOE TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN." Makassar Pharmaceutical Science Journal (MPSJ) 1, no. 3 (2023): 183–94. https://doi.org/10.33096/mpsj.v1i3.91.
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Daun senggani (Melastoma malabathricum L.) merupakan salah satu tumbuhan yang memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui isolat fungi endofit daun senggani (Melastoma malabathricum L.) yang memiliki aktivitas sebagai antibakteri terhadap bakteri saluran pencernaan dengan metode KLT-Bioautografi. Hasil penelitian ini menunjukkan dua isolat fungi endofit daun senggani (Melastoma malabathricum L.). IFDS 6 didapatkan bercak dengan nilai Rf 0,58 pada bakteri Eschericia coli, nilai Rf 0,67 pada bakteri Vibrio cholerae, Salmonella typhi dan Shigella dysentriae. Sedangkan, IFDS 8 didapatkan bercak dengan nilai Rf 0,78 pada bakteri Eschericia coli, Vibrio cholerae, Salmonella typhi, dan Shigella dysentriae
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Yeni Agustin and Mayaranti Wilsya. "UJI IN VIVO INFUSA DAUN SENGGANI (Melastoma malabathricum L.) SEBAGAI ANTI DIARE." Jurnal Kesehatan : Jurnal Ilmiah Multi Sciences 12, no. 01 (2022): 52–56. http://dx.doi.org/10.52395/jkjims.v12i01.343.
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Diare merupakan salah satu masalah kesehatan masyarakat di negara berkembang seperti Indonesia. Terdapat beberapa alternatif pengobatan diare salah satunya dengan pemberian obat tradisional. Tanaman yang dimanfaatkan sebagai antidiare adalah senggani (Melastoma malabathricum L.). Kandungan senyawa telah diketahui yaitu memiliki kandungan tanin, flavonoid dan saponin. Tujuan penelitian ini adalah untuk mengetahui dosis berapa infusa daun senggani (Melastoma malabathricum L.) yang efektif sebagai antidiare pada mencit yang diinduksi oleum ricini. Penelitian ini merupakan penelitian eksperimental dengan melakukan uji sebelum dan sesudah perlakuan. Ada lima kelompok perlakuan antara lain kontrol negatif (CMC Na 1%), kontrol positif (Loperamid), dan tiga kontrol perlakuan infusa daun senggani (Melastoma malabathricum L.)dengan variasi dosis 25 mg, 50 mg dan 100 mg. Data dianalisis secara statistik menggunakan uji one way anova dan dilanjutkan uji post hoc with Duncan pada CI 95%, untuk menentukan efektifitas kelompok perlakuan terhadap penurunan frekuensi diare. Dan juga menilai perbaikkan konsistensi feses mencit. Data hasil penelitian menunjukkan infusa daun senggani (Melastoma malabathricum L.) dosis 100 mg memiliki efek antidiare yang sama dengan Loperamid (kontrol positif) dalam menurunkan frekuensi diare pada jam ke-3 sebesar 100%. Dan juga mampu memperbaiki konsistensi feses ke keadaan normal kembali.
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Rauf, Aulia Azizah, Himaniarwati, and Selpirahmawati Saranani. "Penetapan Kadar Polifenol Total Dan Tanin Total Dari Ekstrak Etanol Buah Senggani (melastoma malabathricum L.) Serta Uji Aktivitas Antioksidan Dengan Metode ABTS." Jurnal Pharmacia Mandala Waluya 2, no. 6 (2023): 295–304. http://dx.doi.org/10.54883/jpmw.v2i6.40.
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Senggani (melastoma malabathricum L.) adalah tumbuhan berbunga dalam famili melastomaceace. Tanaman senggani secara empiris digunakan oleh masyarakat sebagai obat luka dengan dikunyah kemudian ditempelkan pada bagian luka, dapat juga digunakan untuk mengobati borok, diare, dan disentri. Serta bagian bunga senggani dapat dikonsumsi karena memiliki banyak manfaaat. Tujuan penelitian ini yaitu untuk mengetahui kadar fenol total dan tanin total serta aktivitas antioksidan serta aktivitas antioksidan dengan metode ABTS pada buah senggani (melastoma malabathricum L.). Penelitian ini merupakan penelitian eksperimental laboratorium dengan jenis penelitian model deskriptif. Sampel diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% kemudian dilakukan skrining fitokimia dan penentuan kadar polifenol total dan tanin total serta uji aktivitas antioksidan dengan metode ABTS dengan Analisa senyawa menggunakan Spektrofotometer Uv-Vis. Analisis data dilakukan dengan analisis kualitatif dan kuantitatif. Hasil skrining fitokimia menunjukkan bahwa buah senggani (melastoma malabathricum L.) mengandung golongan metabolit Alkaloid, Saponin, Flavanoid, Fenolik, Tanin, dan Terpenoid, sedangkan mgGAE/g, dan Tanin Total 1,865 mgTAE/g dan ekstrak etanol buah senggani (melastoma malabathricum L.) memiliki nilai IC₅₀ 13,159 ppm dan dapat dikategorikan ke dalam antioksidan sangat kuat meskipun lebih kecil bila dibandingkan dengan IC₅₀ pada Vitamin C yakni 1.890 ppm.
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Samosir, Muhammad Arif Samosir, Almuzafri, and Rizah Rizwana Wahyuni. "UJI EFEKTIVITAS EKSTRAK DAUN SENDUDUK (Melastoma malabathricum L.) SEBAGAI ANTIBAKTERI Salmonella typhi." SUNGKAI 12, no. 2 (2024): 84–92. https://doi.org/10.30606/sungkai.v12i2.2847.
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This research on the effectiveness test of Melastoma malabathricum L. plants as antibacterial agents for Salmonella was conducted from September to October 2023. The purpose of this study was to prove that Senduduk leaf extract (Melastoma malabathricum L.) is effective as an antibacterial against Salmonella typhi. The disc diffusion method was used as an antibacterial fraction to be tested by being absorbed on disc paper, the descriptive method was used to see the antibacterial ability which was arranged based on variations in solutions with 5 treatments in duplicate. Treatment with variations in senduduk leaf extract solutions of 20%, 40%, 60% and 80% and sterile aquadest as a control. The results of the study showed that the Melastoma malabathricum L. plant originating from the land of the Faculty of Agriculture is a plant that has a content in accordance with the phytochemical content described by (Afrianti M, Dwiloka B, Setiani B E, 2013). In The Inhibition Test, The Variation Of The 80% Leaf extract solution produced an inhibition zone with the largest diameter of 18.25 mm, this indicates that the Melastoma malabathricum L. leaf extract has better inhibition compared to the 20%, 40% and 60% leaf extract concentrations.
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Mardiana, Mardiana, Etiek Nurhayati, and Supriyanto Supriyanto. "Perbedaan Perasan dan Rebusan Daun Cengkodok (Melastoma malabathricum L.) dalam Menghambat Pertumbuhan Jamur Trichophyton rubrum." Jurnal Laboratorium Khatulistiwa 2, no. 2 (2019): 76. http://dx.doi.org/10.30602/jlk.v2i2.336.
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Abstract: Cengkodok leaves (Melastoma malabtahricum L.) is one of plant that has usefulness like medicine and has the potential to be researched. One of the usefulness of treating skin diseases caused by Trichophyton rubrum fungus. The research aims to determine the defference of juice and boiled of cengkodok leaves (Melastoma malabathricum L.) in inhibiting the growth of Trichophyton rubrum fungus. Each treatment of juice and stew has concentrations of 10%, 20%, 30%, 40%, 50%, 60%,70%, 80%, 90%, 100%. The research method is a quasi experiment, sampling technique by purposive sampling, and use method of solid dilution using PDA (Potato Dextrose Agar) with 3 replications. The results of the research on the juiced treatment that concentration of 10% have an average growth 261 CFU. The higher concentration of antifungi ingredients then the number of fungal colonies growth decreases until concentration of 100% have an average growth 12 CFU. The 10% concentration boiled treatment there was an average growth of 205 CFU and the number of fungal colonies growth decreases at concentration of 100% have an average growth 1 CFU. Effective concentration of cengkodok leaves juiced (Melastoma malabathricum L.) starts from concentration of 60% with inhibiting Trichophyton rubrum growth fungus 52,77% and boiled start from concentration 50% with percentage of inhibiting 59,41%. The data obtained were analyzed statistically using independent t test obtained p value (Sig. 2 tailed) 0.116 > 0.05. The results showed no difference between the juice and boiled of Cengkodok leaves (Melastoma malabathricum L.) in inhibiting Trichophyton rubrum fungus.Abstrak: Daun cengkodok (Melastoma malabathricum L.) merupakan tumbuhan berkhasiat obat, salah satu khasiatnya yakni mengobati penyakit kulit yang diakibatkan oleh Jamur Trichophyton rubrum. Penelitian ini bertujuan untuk mengetahui perbedaan perasan dan rebusan daun cengkodok (Melastoma malabathricum L.) dalam menghambat pertumbuhan jamur Trichophyton rubrum. Masing-masing perlakuan memiliki konsentrasi 10%, 20%, 30%, 40%, 50%, 60%,70%, 80%, 90%, 100%. Metode penelitian ini adalah Quasi Experiment, teknik pengambilan sampel dengan cara purposive sampling, dan menggunakan metode dilusi padat menggunakan media PDA (Potato Dextrose Agar) dengan 3 replikasi. Hasil penelitian pada perlakuan perasan konsentrasi 10% terdapat rata-rata pertumbuhan jumlah koloni jamur yakni 261 CFU. Semakin tinggi konsentrasi bahan antifungi maka jumlah pertumbuhan koloni jamur semakin berkurang hingga pada konsentrasi 100% terdapat rata-rata jumlah koloni jamur yakni 12 CFU. Pada perlakuan rebusan konsentrasi 10% terdapat rata-rata pertumbuhan jumlah koloni jamur yakni 205 CFU dan semakin berkurang jumlah pertumbuhan koloni jamur pada konsentrasi 100% sebesar 1 CFU. Konsentrasi efektif perasan daun cengkodok (Melastoma malabathricum L.) dimulai dari konsentrasi 60% dengan hambatan pertumbuhan jamur Trichophyton rubrum sebesar 52.77% dan rebusan dimulai dari konsentrasi 50% dengan persentase hambatan 59.41%. Dianalisis statistik menggunakan uji independent t test didapatkan hasil p value (Sig. 2 tailed) 0.116 > 0.05 yang menunjukkan tidak terdapat perbedaan antara perasan dan rebusan daun cengkodok (Melastoma malabathricum L.) dalam menghambat jamur Trichophyton rubrum.
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Isnaini, Denny Anata Kusuma, Anthony Hermawan, Fujiati, and Alfi Yasmina. "AKTIVITAS ANTIOKSIDAN DAN SITOTOKSIK BERBAGAI FASE BUNGA MELASTOMA MALABATHRICUM LINN." Jurnal Kesehatan Islam : Islamic Health Journal 13, no. 1 (2024): 9–13. http://dx.doi.org/10.33474/jki.v13i1.21719.
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Abstract. Melastoma malabathricum Linn is one of the medicinal plants, and is used by the community. M. malabathricum L. flowers contain quercetin and kaempferol which have antioxidant and anticancer properties. Each phase of flower M. malabathricum L. has different quercetin and kaempferol contents. This study aims to analyze the differences in antioxidant and toxicity activities of various phases of karamunting flowers by DPPH and brine shrimp lethality (BSLT) methods. Antioxidant activity is expressed by IC50 while toxicity activity is expressed by LC50. IC50 and LC50 are calculated using probit analysis. The blooming phase has the greatest antioxidant and toxicity activity (IC50 6,989 ppm (95% CI 6,358 ± 9,276) and LC50 146,325 ppm (95% CI 101,257 ± 215,766) while bud flower phase 2 has the smallest antioxidant and toxicity activity (IC50 8,866 ppm (95% CI 8.075 ± 9,874) and LC50 233,222 ppm (95% CI 151,662 ± 408,101). Conclusion The flower phase of Melastoma malabatricum Linn has low antioxidant activity, causing its toxic properties to be lower Kata Kunci: flower phases, Melastoma malabathricum Linn; antioxidant; toxicity
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Joffry, S. Mohd, N. J. Yob, M. S. Rofiee, et al. "Melastoma malabathricum(L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–48. http://dx.doi.org/10.1155/2012/258434.
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Melastoma malabathricumL. (Melastomataceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese, and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds, and roots ofM. malabathricumhave been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts ofM. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic, and antioxidant activities. Various types of phytochemical constituents have also been isolated and identifed from different parts ofM. malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents, and pharmacological activities ofM. malabathricum.
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Anggriani, Adelia, Chindiana Khutami, Yuni Andriani, and Septa Pratama. "Uji Efektivitas Analgesik Esktrak Daun Senduduk (Melastoma malabathricum L.) terhadap Mencit Jantan." Pharmaceutical Science and Clinical Pharmacy 3, no. 1 (2025): 1–8. https://doi.org/10.61329/pscp.v3i1.36.
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Nyeri adalah pengalaman yang terakait dengan kerusakan jaringan aktaual atau potensial yang bersifat subyektif. Penggunaan OAINS dalam mengatasi nyeri dalam jangka panjang memiliki efek samping seperti gangguan lambung dan usus, kerusakan pada ginjal. Secara empiris daun senduduk ungu (Melastoma malabathricum L.) mengandung senyawa metabolit sekunder yang mempunyai kemampuan sebagai analgesik. Tujuan penelitian mengetahui efektivitas analgesik dan dosis yang tepat ekstrak etanol daun senduduk (Melastoma malabathricum L.) terhadap mencit jantan yang diuji menggunakan metode tail flick. Hewan uji yang digunakan dalam penelitian ini sebanyak 25 ekor. Uji analgesik terdiri dari kelompok kontrol positif, negatif dan variasi dosis 400 mg/kgBB, 600 mg/kgBB dan 800 mg/ kgBB. Hasil pengamatan menujukan bahwa ekstrak daun senduduk (Melastoma malabthricum L.) memiliki efektivitas analgesik yang ditunjukan dengan perpanjangan waktu respon penjetikan ekor. Pada dosis ekstrak 600 mg/kgBB dan 800mg/kgBB merupakan dosis yang paling efektif sebagai analgesik dengan persentase hambatan yaitu 82,3% dan 93,5%.
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Maisarah, Z., Siti, Nurul-Aini C.A.C., Rozilawati, S., and Noor-Syaheera, M. Y. "TAXONOMIC IMPORTANCE OF ANTICLINAL WALLS AND STOMATA PATTERNING IN SOME MELASTOMA L. SPECIES FROM FRASER HILL." Science Heritage Journal 4, no. 1 (2020): 24–26. http://dx.doi.org/10.26480/gws.01.2020.24.26.
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The epidermal characteristics of five selected Melastoma L. species in Fraser Hill, Pahang that belongs to Melastomataceae family had been investigated. These five species namely M. muticum Ridl., M. decemfidum Roxb., M. perakense Ridl., M. sanguineum x malabathricum and M. malabathricum var. normale. The objective of this study is to determine whether epidermal characteristics in Melastoma could be taxonomic value in systematic and diagnostic investigations. Methods of the investigation involved epidermal peel and scanning electron microscopy. Results obtained revealed that the presence of hypostomatic stomata and guard cells pairs were elliptic in shaped for all species studied. Apart, the pattern of anticlinal walls on adaxial and abaxial surfaces was straight to wavy for all species studied except for wavy to sinuous anticlinal walls on abaxial surface of M. sanguineum x malabathricum. Furthermore, two types of stomata were observed among species studied such as anomocytic and diacytic stomata. Results showed that diacytic type was only present in M. sanguineum x malabathricum therefore could be a criterion to diagnose the species. Lastly, this present study was also reported on the presence of two types of guard cell pairs such as raised or slightly raised and sunken guard cell pairs. In conclusion, the present study revealed that the anticlinal walls and stomata patterning possess as taxonomic importance in identification and classification of Melastoma either at genus or species level.
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Septiana, Lilik, Rida Evalina Tarigan, Muhammad Andry, Vannissa Andriani Irawan, and Muhammad Amin Nasution. "Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus)." Journal of Pharmaceutical and Sciences 6, no. 3 (2023): 1339–45. http://dx.doi.org/10.36490/journal-jps.com.v6i3.220.
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Pendahuluan; daun senggani memiliki senyawa metabolit sekunder yang dapat menghambat pengeluaran aldosteron sehingga lebih banyak air dikeluarkan dari tubuh dan tekanan darah akan turun. Tujuan; untuk mengetahui efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) terhadap penurunan tekanan darah mencit putih jantan (Mus musculus). Metode; eksperimental yang meliputi pengambilan sampel, pengolahan sampel, pembuatan ekstrak, karakteristik simplisia, penyiapan bahan uji, perlakuan terhadap hewan uji dan analisa data. Sampel yang digunakan yaitu daun senggani (Melastoma malabathircum L.) Hewan uji yang digunakan adalah 15 ekor mencit putih jantan kemudian dibagi menjadi 5 kelompok. Pengukuran tekanan darah menggunakan alat blood presure analyzer dengan etode tail cuff. Data hasil pengukuran kemudian dianalsis menggunakan uji paired t-test dengan batas kemaknaan 0,05. Hasil; ekstrak etanol daun senggani memiliki efektivitas antihipertensi dengan hasil pengukuran tekanan darah sistol paling rendah setelah perlakuan pada EEDS 150 mg/kgBB yaitu 86,66 mmHg dan diastol diperoleh tekanan darah paling rendah setelah perlakuan pada EEDS 150 mg/KgBB yaitu 59 mmHg. Hasil uji statistik paired t-test diperoleh adanya pengaruh pemberian bahan uji EEDS 50 mg/kgBB, EEDS 100 mg/kgBB, EEDS 150 mg/kgBB uji selama 14 hari dengan p-value < 0,05. Pada tekanan darah diastol pengaruh perlakuan pemberian bahan uji terhadap tekanan darah yang signifikan terdapat pada EEDS 150 mg/kgBB dengan p-value = 0,001. Kesimpulan; Pemberian ekstrak etanol daun senggani (Melastoma malabathricum L.) dapat menurunkan tekanan darah hewan coba mencit jantan (Mus musculus). Ekstrak etanol daun senggani (Melastoma malabathricum L.) efektif dalam menurunkan tekanan darah pada dosis 150 mg.
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Septiani, Septiani. "The Uji Aktivitas Antioksidan Ekstrak Buah Senggani (Melastoma malabathricum L.) dan Ekstrak Buah Bit (Beta vulgaris L.)." KATALIS: Jurnal Penelitian Kimia dan Pendidikan Kimia 3, no. 2 (2021): 35–41. http://dx.doi.org/10.33059/katalis.v3i2.3108.
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Penelitian ini dilakukan dengan tujuan untuk mengetahui jenis metabolit sekunder dan aktivitas antioksidan dari buah senggani (Melastoma malabathricum L.) dan ekstrak buah bit (Beta vulgaris L.). Ekstrak buah senggani dan buah bit diperoleh dengan cara maserasi. Pengujian antioksidan dilakukan dengan metode peredaman radikal bebas oleh 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil penelitian berdasarkan pengujian skrining fitokimia menunjukkan bahwa ekstrak buah senggani dan buah bit memiliki kandungan senyawa metabolit sekunder golongan alkaloid, flavonoid, dan tanin. Hasil penelitian berdasarkan pengujian antioksidan diperoleh berdasarkan nilai absorbansi dan nilai % inhibisi. Nilai % inhibisi tertinggi buah senggani dan buah bit diperoleh pada konsentrasi yang sama, yaitu 10 ppm sebesar 70,14% dan 55,87%. Nilai IC50 dari ekstrak buah senggani dan buah bit menunjukkan aktivitas antioksidan yang sangat kuat yaitu sebesar 4,63 ppm dan 7,77 ppm. Berdasarkan penelitian ini, dapat disimpulkan bahwa ekstrak buah senggani (Melastoma malabathricum L.) dan buah bit (Beta vulgaris L.) berpotensi sebagai antioksidan dan mampu menghambat radikal bebas.
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Septiani, Septiani. "The Uji Aktivitas Antioksidan Ekstrak Buah Senggani (Melastoma malabathricum L.) dan Ekstrak Buah Bit (Beta vulgaris L.)." KATALIS: Jurnal Penelitian Kimia dan Pendidikan Kimia 3, no. 2 (2021): 35–41. http://dx.doi.org/10.33059/katalis.v3i2.3108.
Full textAbstract:
Penelitian ini dilakukan dengan tujuan untuk mengetahui jenis metabolit sekunder dan aktivitas antioksidan dari buah senggani (Melastoma malabathricum L.) dan ekstrak buah bit (Beta vulgaris L.). Ekstrak buah senggani dan buah bit diperoleh dengan cara maserasi. Pengujian antioksidan dilakukan dengan metode peredaman radikal bebas oleh 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil penelitian berdasarkan pengujian skrining fitokimia menunjukkan bahwa ekstrak buah senggani dan buah bit memiliki kandungan senyawa metabolit sekunder golongan alkaloid, flavonoid, dan tanin. Hasil penelitian berdasarkan pengujian antioksidan diperoleh berdasarkan nilai absorbansi dan nilai % inhibisi. Nilai % inhibisi tertinggi buah senggani dan buah bit diperoleh pada konsentrasi yang sama, yaitu 10 ppm sebesar 70,14% dan 55,87%. Nilai IC50 dari ekstrak buah senggani dan buah bit menunjukkan aktivitas antioksidan yang sangat kuat yaitu sebesar 4,63 ppm dan 7,77 ppm. Berdasarkan penelitian ini, dapat disimpulkan bahwa ekstrak buah senggani (Melastoma malabathricum L.) dan buah bit (Beta vulgaris L.) berpotensi sebagai antioksidan dan mampu menghambat radikal bebas.
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Rusli, Lili Syahani, Rosazlin Abdullah, Jamilah Syafawati Yaacob, and Normaniza Osman. "Organic Amendments Effects on Nutrient Uptake, Secondary Metabolites, and Antioxidant Properties of Melastoma malabathricum L." Plants 11, no. 2 (2022): 153. http://dx.doi.org/10.3390/plants11020153.
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Amelioration of soil acidity can boost soil fertility, hence increasing nutrient uptake, secondary metabolite, and its antioxidant potential. In the present study, the effectiveness of food waste compost and palm kernel biochar was assessed as soil amendments for Melastoma malabathricum L. grown in acidic soil conditions. A six-month greenhouse study was conducted using completely randomized design (CRD) with three treatment groups, including control plants (T1), plants amended with palm kernel biochar (T2), and plants amended with food waste compost (T3). Data analysis revealed that Melastoma malabathricum L. amended with T3 recorded the highest total chlorophyll content (433.678 ± 13.224 µg g−1 DW), followed by T2 and T1. The increase in chlorophyll content was contributed by the increase in soil pH. This was shown by the positive significant correlations between soil pH and chlorophyll a (r2 = 0.96; p ≤ 0.01) and chlorophyll b (r2 = 0.778; p ≤ 0.01). In addition, the same treatment exhibited the highest total anthocyanin content (leaves; 36.1 × 10−2 ± 0.034 mg/g DW and root extract; 8.9 × 10−2 ± 0.020 mg/g DW), total phenolic content (stem extract; 4930.956 ± 16.025 mg GAE/g DE), and total flavonoid content (stem extract; 209.984 ± 0.572 mg QE/g DE). Moreover, this study also found that the highest antioxidant potential against 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals was exhibited by samples supplemented with food waste compost (T3), followed by palm kernel biochar (T2). This indicates that the soil amendments have the capacity to enhance the secondary metabolites that protect plants, therefore ameliorating Melastoma malabathricum L.’s response towards acidic stress, and resulting in better antioxidant properties. Furthermore, this study also recorded better nutrient uptake in T3. With the significantly higher levels of macronutrient in the soil, the food waste compost could enhance the nutrient properties, secondary metabolites, and antioxidant capacity of Melastoma malabathricum L. grown in acidic soil conditions.
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Winata, Hanafis Sastra, Hafizhatul Abadi, Leny Leny, et al. "FORMULASI DAN UJI ANTIDIARE SEDIAAN PATCH TRANSDERMAL EKSTRAK DAUN SENGGANI (Melastoma malabathricum L.) TERHADAP KELINCI." AGRIBIOS 22, no. 2 (2024): 238. https://doi.org/10.36841/agribios.v22i2.5494.
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One plant that has been used for traditional medicine with good results is Melastoma (Melastoma malabatricum L.). The plant known as Melastoma has three active compounds: tannins, saponins, and flavonoids. Melastoma leaves work well to cure diarrhoea. Adhesive patches with medication applied topically are called transdermal patches. Melastoma leaf extract transdermal patch formulations were utilised in this study, which employed laboratory experimental techniques. The potential of Melastoma leaf extract transdermal patch preparation formula as an antidiarrheal for rabbits was the subject of the study. Concentrations of extract: 10%, 20%, and 30%. Organoleptic testing, pH tests, weight uniformity tests, moisture tests, thickness tests, and fold resistance tests were the preparatory assessment parameters that were conducted. The characteristics of the antidiarrheal test were timing of diarrhoea occurrences, consistency of the stool, frequency of diarrhoea, and length of diarrhoea, all of which were monitored for six hours. The evaluation of the Melastoma leaf extract transdermal patch formulation demonstrated a significant difference, namely <0.05, according to the results of the ANOVA data analysis. The antidiarrheal test parameters had a significant difference between each concentration, namely <0.05, according to the findings of the ANOVA data analysis. The conclusions was possible to use a transdermal patch formulation of Melastoma leaf extract (Melastoma malabathricum L.) at a 30% concentration to prevent diarrhoea by making stools softer.
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Fikayuniar, Lia, Ermi Abriyani, Fioren Irwandira, Sinta Bela, and Sartika Dewi. "UJI TOKSISITAS MENGGUNAKAN METODE BSLT DAN SKRINING FITOKIMIA EKSTRAK (Melastoma malabathricum L.)." Jurnal Buana Farma 2, no. 2 (2022): 67–71. http://dx.doi.org/10.36805/jbf.v2i2.394.
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Melastoma malabathricum L. plant or commonly known as senduduk is often used as a source of food and medicine. The stem of senduduk is one part of the senduduk plant that has not been widely utilized in existence compared to its flowers, fruits and leaves. Senduduk plant has activity as antidiarrhea, fractures, digestive tract disorders, melancholy, seizures, epilepsy, abdominal pain, thrush, anti-inflammatory, antipyretic, wound, and antioxidant, in addition to the myriad benefits of M. malabathricum L. also contains toxic compounds. Therefore, this study aims to determine the toxic activity of n-hexane extract, ethyl acetate, senduduk stem methanol (M. malabathricum L.) against A. salina L. shrimp larvae to avoid toxic risks in humans. The method used in the study was the Brine Shrimp Lethality Test (BSLT) using 10 shrimp larvae A. salina L. in each replication carried out three times afterwards followed by probit analysis to see the percentage of shrimp larva death. The study also found results that n-Hexane extract contains flavonoids, quinones and saponins, while ethyl acetate and methanol extracts contain only flavonoids and quinone. Senduduk stem extract (M. malabathricum L.) has a toxic effect with a value of LC50 < 1000 ppm or in the n-Hexane extract of 1.66 ppm, while in ethyl acetate extract of 56.23 ppm and methanol extract of 128.82 ppm.
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Yusoff, Aiman, N. T. R. N. Kumara, Andery Lim, Piyasiri Ekanayake, and Kushan U. Tennakoon. "Impacts of Temperature on the Stability of Tropical Plant Pigments as Sensitizers for Dye Sensitized Solar Cells." Journal of Biophysics 2014 (February 23, 2014): 1–8. http://dx.doi.org/10.1155/2014/739514.
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Natural dyes have become a viable alternative to expensive organic sensitizers because of their low cost of production, abundance in supply, and eco-friendliness. We evaluated 35 native plants containing anthocyanin pigments as potential sensitizers for DSSCs. Melastoma malabathricum (fruit pulp), Hibiscus rosa-sinensis (flower), and Codiaeum variegatum (leaves) showed the highest absorption peaks. Hence, these were used to determine anthocyanin content and stability based on the impacts of storage temperature. Melastoma malabathricum fruit pulp exhibited the highest anthocyanin content (8.43 mg/L) followed by H. rosa-sinensis and C. variegatum. Significantly greater stability of extracted anthocyanin pigment was shown when all three were stored at 4∘C. The highest half-life periods for anthocyanin in M. malabathricum, H. rosa-sinensis, and C. variegatum were 541, 571, and 353 days at 4∘C. These were rapidly decreased to 111, 220, and 254 days when stored at 25∘C. The photovoltaic efficiency of M. malabathricum was1.16%, while the values for H. rosa-sinensis and C. variegatum were 0.16% and 1.08%, respectively. Hence, M. malabathricum fruit pulp extracts can be further evaluated as an alternative natural sensitizer for DSSCs.
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Tuan Zainal Abidin, Tengku Muna Shaheera, Mohd Rozi Ahmad, Muhammad Ismail Ab Kadir, Nor Juliana Mohd Yusof, and Wan Yunus Wan Ahmad. "Ultrasound Dyeing of Polyester Using Natural Colorant from Melastoma malabathricum l." Advanced Materials Research 1134 (December 2015): 66–69. http://dx.doi.org/10.4028/www.scientific.net/amr.1134.66.
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This paper reports on the application of natural dyes on polyester fabric. Melastoma malabathricum l. was extracted using conventional method of boiling for an hour. Plain lightweight polyester fabric was treated with sodium hydroxide as an alkaline treatment and Chitosan prior to dyeing in an attempt to increase the dye uptake. The dye extract of Melastoma malabathricum l. was applied on the polyester fabric at 85°C for an hour by exhaustion dyeing and 40 minutes for ultrasound dyeing. The colors of the dyed fabrics were measured using colour spectrophotometer and evaluated for washfastness. Ultrasound dyeing gave deeper colour shades to the fabric even though dyeing was conducted at lower temperature for 40 minutes. The alkaline treated fabrics dyed using ultrasound gave lower value of L* which indicate higher dye uptake and darker colour. The ratings for colourfastness to washing were between 4/5 to 5.
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Truong, Le Cong. "Reducing the Effects of Blood Sugar Infusion of Melastoma Malabathricum L. in Mus Musculus." Journal of Asian Multicultural Research for Medical and Health Science Study 1, no. 1 (2020): 1–10. http://dx.doi.org/10.47616/jamrmhss.v1i1.17.
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This study aims to determine the blood sugar-lowering effect of Melastoma malabathricum L. infusion on Mus musculus. The research design used was an experimental laboratory carried out in the pharmacology laboratory of the Ho Chi Minh City University. This study used 15 male mice which were divided into 5 groups consisting of group I as negative control by giving aquadest, groups II, III, IV were given infusion of Melastoma malabathricum L. respectively 0.1 g/ml, 0.2 g/ml, and 0.4 g/ml, and group V as a positive control with glibenclamide suspension. The results showed that statistical testing using the SPSS program showed a significant difference (p <0.05), which means that senggani leaf infusion had a significant effect on reducing blood sugar levels in mice and the most optimal was 0.4 g/ml infusion.
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Tandirogang, Nataniel, Swandari Paramita, Yadi Yasir, Yuniati Yuniati, Meiliati Aminyoto, and Evi Fitriany. "Aktivitas Antimikroba Ekstrak Daun Karamunting (Melastoma malabathricum L.) Terhadap Bakteri Penyebab Diare." Jurnal Sains dan Kesehatan 1, no. 7 (2017): 345–51. http://dx.doi.org/10.25026/jsk.v1i7.54.
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Diare hingga kini masih merupakan masalah kesehatan utama di Indonesia. Pemberian antibiotik merupakan salah satu upaya penatalaksanaan diare, namun belakangan terkendala masalah adanya resistensi terhadap antibiotik. Berdasarkan hal tersebut, maka upaya pencarian sumber antimikroba baru berbasis tumbuhan obat perlu dilakukan. Penelitian ini dilakukan untuk menguji potensi ekstrak daun karamunting (Melastoma malabathricum L.) yang secara tradisional digunakan etnis Dayak sebagai obat diare. Aktivitas antimikroba ekstrak tumbuhan diuji terhadap 5 bakteri standar; Escherichia coli ATCC 35128, Shigella sonnei ATCC 25931, Campylobacter jejuni ATCC 33291, Pseudomonas aeruginosa ATCC 15442, dan Enterobacter cloacae ATCC13047. Pengukuran aktivitas antimikroba dilakukan dengan disc diffusion method (Kirby-Bauer) dan pengukuran minimum inhibitory concentration (MIC). Hasil penelitian menunjukkan ekstrak daun M. malabathricum dapat menghambat pertumbuhan seluruh bakteri uji, dengan diameter zona hambat sebesar 12,3-16 mm dan MIC sebesar 2,3-13,3 mg/ml. Kesimpulan penelitian ini adalah ekstrak daun M. malabathricum berpotensi sebagai antidiare berdasarkan aktivitas antimikrobanya.
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Noviyanty, Yuska, and Asri Mei Linda. "PROFIL FITOKIMIA SENYAWA METABOLIT SEKUNDER EKSTRAK ETANOL BUNGA SENDUDUK (Melastoma malabathricum L)." Journal of Pharmaceutical And Sciences 3, no. 1 (2020): 1–6. http://dx.doi.org/10.36490/journal-jps.com.v3i1.34.
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Indonesia merupakan salah satu negara yang memiliki keanekaragaman obat didunia. Wilayah hutan tropis indonesia memiliki keanekaragaman hayati tettinggi ke-2 didunia setelah Brazil. Tanaman senduduk (Melastoma malabathricum L) merupakan salah satu bahan alami yang dapat digunakan sebagai obat tradisional. penelitian ini adalah untuk mengidentifikasi senyawa metabolit sekunder yang terkandung pada ekstrak etanol bunga senduduk (Melastoma malabathricum L). Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol 96% selama 7 hari. Ekstraksi yang diperoleh kemudian dipekatkan dengan alat rotary evaporator. kandungan metabolit sekunder diidentifikasi dengan reaksi warna flavonoid diuji dengan reagen Mg dan HCL, alkaloid diuji dengan mayer, dragendrof, dan wagner saponin diuji dengan reaksi busa, tanin diuji dengan reagen Fecl3 dan triterpenoid/steroid diuji dengan reaksi asam asetat anhidrat. Kemudian dilakukan uji penegasan dengan menggunakan metode kromatografi lapis tipis (KLT). Hasil penelitian menunjukan adanya perubahan warna yang positif ditunjukkan dengan adanya mengandung flavonoid, tannin, dan saponin, dan berdasarkan hasil uji penegasan uji kromatografi lapis lipis (KLT) didapatkan hasil positif flavonoid, tannin, dan saponin.
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Yanuarto, Tri, Devi Novia, and Septi Putri Lestari. "FORMULASI SEDIAAN SIRUP SARI BUAH SENGGANI (Melastoma malabathricum L.)." Jurnal Insan Farmasi Indonesia 5, no. 1 (2022): 130–39. http://dx.doi.org/10.36387/jifi.v5i1.914.
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Senggani fruit (Melastoma malabathricum L.) is one of the wild plants whose leaves are usually used by the community as a medicine for wounds and cancer sores. Senggani fruit contains high anthocyanins and antioxidants, which are very good for preventing cancer in the body. The purpose of this research is to make syrup of Senggani fruit juice. The formulation of Senggani fruit juice syrup was made by heating method at 54°C with various concentrations of F0, F1 (5%), F2 (6%) and F3 (8%). Then, the physical properties were tested, namely organoleptic, viscosity test, pH test, homogenity test, hedonic test and descriptive test. From testing the physical properties of the syrup formulation of Senggani fruit, it was found that the organoleptic test of F2 and F3 showed a change in consistency; for the pH test results the four formulas ranged from 3.98 to 7.07; the homogeneity test on F2 and F3 was not homogeneous, there were black grains at the 3rd week; then the viscosity test of syrup preparations F2 and F3 obtained an average result of 30 - 51.33 cPs; as well as hedonic and descriptive tests with the criteria of somewhat like - like the most preferred is F3.
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Wan Ahmad, Wan Yunus, M. A. Mohd Nor, N. Saim, M. I. Ab Kadir, and M. R. Ahmad. "Nano Natural Dyes from Melastoma Malabathricum L." Advanced Materials Research 545 (July 2012): 59–63. http://dx.doi.org/10.4028/www.scientific.net/amr.545.59.
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In this study, natural colours were produced from Melastoma Malabathricum L.’s (Senduduk) plant. The dyes were extracted from the petal part of the plant using solvent extraction method of acidified methanol and methanol. The natural colours were then converted into powder form of nano size scale using a ball mill grinder. Silk fabrics were used as the substrate and dyed using several natural and synthetic mordant. The use of different solvents for extraction and mordant for dyeing resulted in different colour shades on the silk fabrics. The color fastness to washing tests revealed colour fastness to washing ranging from 3 – 4/5 and the change in color ranging from 3/4 – 4/5. The findings will benefit and promote the dyeing and printing industry such as batik manufacturers and local fashion industry in using natural dyes. On the other hand, dyes from plants can also be used as an alternative to synthetic dyes for dyeing natural silk fibers.
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Wong, Keng-Chong, Dafaalla Mohamed Hag Ali, and Peng-Lim Boey. "Chemical constituents and antibacterial activity of Melastoma malabathricum L." Natural Product Research 26, no. 7 (2011): 609–18. http://dx.doi.org/10.1080/14786419.2010.538395.
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Regina, Septiana Barung, Rahardjo Sidharta Boy, and Kianto Atmodjo P. "Antibacterial Activity of Senggani (Melastoma malabathricum L.) Leaves Extract against Pseudomonas aeruginosa and Staphylococcus aureus." Antibacterial Activity of Senggani (Melastoma malabathricum L.) Leaves Extract against Pseudomonas aeruginosa and Staphylococcus aureus 8, no. 12 (2024): 7. https://doi.org/10.5281/zenodo.10473992.
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Ethanolic extract of senggani (Melastoma malabathricum L.) leaf contains secondary metabolites such as flavonoids, tannins, steroids, alkaloids, saponins, and triterpenoids. Flavonoids which are dominant among other compounds have shown antibacterial activity, especially in Pseudomonas aeruginosa and Staphylococcus aureus. The research aims to determine the inhibition zone and minimum inhibition concentration (MIC) of the leaf extract against P. aeruginosa and S. aureus. The leaf extract is done by maceration utilizing 70 % ethanol (pa) and variation of concentrations viz. 5, 10, and 15 % were treated to P. aeruginosa and S. aureus. The positive control is ampicillin, and the negative control is the solvent (ethanol 70 %). The results show that the leaf extract at 15% shows the highest inhibition zone against P. aeruginosa and S. aureus at 0.63±0.18 and 1.48±0.47 cm2 , respectively. The MIC for P. aeruginosa is 15% and for S. aureus is 10%. Keywords:- Melastoma malabathricum, antibacterial activity, MIC, skin infection
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Hainil, Sri, Henny Rachdiati, Rastria Meilanda, and Nanda Asiska. "Identifikasi Flavonoid dari Ekstrak Etanol dan Fraksi Etil Asetat Daun Senduduk (Melastoma malabathricum L) dengan KLT dan Spektrofotometri UV-VIS." Papua Medicine and Health Science 1, no. 1 (2024): 1–8. https://doi.org/10.64141/pmhs.v1i1.5.
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Indonesia yang kaya akan keanekaragaman hayati merupakan habitat bagi berbagai jenis tumbuhan obat yang memiliki potensi besar untuk meningkatkan kesejahteraan masyarakat. Tanaman Senduduk (Melastoma malabathricum L) adalah salah satu contoh yang populer dalam pengobatan tradisional di Indonesia. Daun dari tanaman ini mengandung senyawa flavonoid, sebuah kelompok senyawa fitokimia yang memiliki manfaat kesehatan yang beragam, sehingga menarik minat peneliti untuk melakukan studi lebih lanjut. Penelitian ini bertujuan untuk mengetahui golongan senyawa flavonoid yang terdapat pada ekstrak etanol dan fraksi etil asetat daun Senduduk (Melastoma malabathricum L) dengan metode KLT dan spektrofotometri uv-vis. Daun Senduduk diekstraksi dengan menggunakan metode maserasi menggunakan pelarut etanol 70%. Skrining fitokimia dilakukan untuk mengetahui senyawa yang terkandung pada daun Senduduk. Pemisahan senyawa dilakukan dengan menggunakan metode KLT, dengan kuarsetin sebagai pembanding. Hasil penelitian menunjukan nilai Rf pembanding dan sampel sebesar 7,3. Hasil uji menggunakan spektrofotometri uv-vis menunjukkan bentuk spektrum yang sama antara pembanding dan sampel, jadi dapat disimpulkan bahwa senyawa flavonoid pada daun Senduduk termasuk golongan kuarsetin.
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Saberi, Shahida, Mohd Izuan Effendi Halmi, Noor Amalina Ramle, and Khairil Mahmud. "Metals Accumulation of Tropical Shrub Melastoma malabathricum L. (Melastomataceae) Populations and Their Relation To Soil Edaphic Factor." Malaysian Applied Biology 53, no. 1 (2024): 113–25. http://dx.doi.org/10.55230/mabjournal.v53i1.2793.
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Melastoma malabathricum L. (Melastomataceae) is a widely distributed tropical shrub that grows in Southeast Asia. Recent research found that M. malabathricum has a bioremediatory potential that can accumulate high concentrations of toxic metals such as Al, Pb, As, and Cr. Thus, this study aimed to investigate the metal hyperaccumulation in M. malabathricum from various populations and their relation to soil edaphic factors. We collected mature leaves and soils of M. malabathricum from 15 different populations in Negeri Sembilan, Selangor, and Pahang in Peninsular Malaysia. These 15 populations consist of lowland forests, dump sites, riparian, oil palm and rubber plantations, paddy fields, and mining sites. We found that M. malabathricum accumulated high concentrations of Al (3.45±1.58 to 8.697±1.61 mg g-1) followed by Fe (1.02±0.02 to 1.07±0.04 mg g-1), Pb (0.013±0.001 to 0.016±0.001 mg g-1), As (0.008±0.005 to 0.23±0.004 mg g-1), and Cr (0.005±0.0003 to 0.02±0.01 mg g-1). The highest concentration of soil Al was 85.95±5.00 mg g-1, Fe with 69.960±7.47mg g-1, Pb with 0.192±0.03 mg g-1, As with 0.156±0.06 mg g-1 and Cr with 0.133±0.03 mg g-1. We found no significant association between high foliar metal concentrations of the metals (Al, Pb, As & Cr) with the soil chemical properties but some soil metal elements were intercorrelated with foliar metal concentrations. Understanding the potential of M. malabathricum in accumulating high levels of metal elements, provides useful information for phytoremediation works. Further research is required to investigate the mechanism uptake and tolerance of heavy metals in M. malabathricum.
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Watanabe, Toshihiro, Seiji Misawa, and Mitsuru Osaki. "Aluminum accumulation in the roots of Melastoma malabathricum, an aluminum-accumulating plant." Canadian Journal of Botany 83, no. 11 (2005): 1518–22. http://dx.doi.org/10.1139/b05-111.
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Generally, plants that have Al levels of at least 1000 mg·kg–1 in their leaves are defined as Al accumulators. These plants are often found in very acid soils in the tropics. The mechanisms of Al uptake in strong Al accumulators are still unclear. In this study, we investigated the characteristics of Al uptake and accumulation in the roots of Melastoma malabathricum L., an Al-accumulating plant that grows in acidic soils in the tropics. Melastoma malabathricum roots hardly absorb any La, possibly because of lower affinity of the root apoplast to La than to Al. Exposure to La did not affect the concentration of citrate in the roots; however, application of Al increased the citrate level considerably, corresponding with the amount of Al accumulation in the symplast. 27Al NMR analysis revealed that Al complexes with oxalate, but not with citrate, in the roots of M. malabathricum. This investigation revealed that oxalate, which occurs constitutively at high concentrations, is a ligand for Al accumulation in both root and shoot tissue, and that citrate, the synthesis of which is induced by Al application, is a ligand mainly used for Al translocation from the roots to the shoots.
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Laia, Yustina Yasnidar, Yoridha Aulia, Mita Sahara, and Maxwel Simanjuntak Masdalena. "Test of Activities of Hepatoprotector of Senggani Leaf Ethanol Extract (Melastoma Malabathricum L.) ON RAT (Rattus Novergicus) That Induced by Paracetamol." Biospecies 12, no. 2 (2019): 1–8. http://dx.doi.org/10.22437/biospecies.v12i2.7073.
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Senggani leaves (Melastoma Malabathricum L.) are easily available plans that are sometimes used as traditional medicine. This study aimed to determine the hepatotective activity of the ethanol of senggani leaves (Melastoma Malabathricum L.) on rats (Rattus Novergicus) induced by paracetamol with histopatological parameters. Making extracts was carried out by maceration using 96% ethanol solution. The test animals used were 30 rats (Rattus Novergicus) which were divided into 6 groups. Group I without treatment, group II as negative control, group III as positive control, and group IV, V, and VI who were given senggani leaf extract, respectively 100 mg/Kg bb, 200 mg/Kg bb, and 400 mg/Kg bb for 7 day. On the 8 day all rats except group I, were induced paracetamol 180 mg/200 gr bb as the parent of liver demage. The resulst showed that the ethanol extract of senggani leaves at a dose of 400 mg/Kg bb was the most effective in hepatoprotective activity compared to a dose of 100 mg/Kg bb, and 200 mg/Kg bb with histopathological parameters induced by paracetamol.
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Oktarina, Tri, Peni Indrayudha, and Rima Munawaroh. "CYTOTOXICITY TEST OF N-HEXANE, ETHYL ACETATE, AND WATER FRACTIONS FROM THE ETHANOL EXTRACT OF SENDUDUK LEAVES (Melastoma malabathricum L.) ON MCF-7 CELLS USING THE MTT ASSAY METHOD." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 1 (2024): 355–62. http://dx.doi.org/10.37874/ms.v9i1.1119.
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The world's richest flora may be found in Indonesia, where a variety of plants, such as the sesame plant (Melastoma malabathricum L) or MM, may be used to treat cancer. According to earlier studies, the methanol extract of the leaves had a substantial anticancer effect on the MCF-7 cell line, with an IC50 of 7.14 µg/mL. The purpose of this study was to evaluate the cytotoxic potential of the water, ethyl acetate, and n-hexane fractions of senduduk leaf ethanol extracts. Maceration was the extraction technique, partitioning (liquid-liquid extraction) was the fractionation technique, and the MTT method was employed to assess cytotoxic activity. The n-hexane, ethyl acetate, and water fractions showed cytotoxic effects with IC50 values of 137.200 µg/mL, 17.108 µg/mL, and 610.863 µg/mL, respectively. The water and n-hexane fractions were classified as fragile, based on the results of the cytotoxicity test. The ethyl acetate fraction, on the other hand, was added to the active category for suppressing MCF-7 cells. Keywords: Melastoma malabathricum L, Cytotoxic, Cells, MCF-7, MTT assay
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Balamurugan, K., G. Sakthidevi, and VR Mohan. "ANTI-INFLAMMATORY ACTIVITY OF LEAF OF MELASTOMA MALABATHRICUM L. (MELASTOMATACEAE)." International Journal of Research in Ayurveda and Pharmacy 3, no. 6 (2012): 801–2. http://dx.doi.org/10.7897/2277-4343.03622.
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Prima, Annisa, and Sri Zulfia Novrita. "PENGARUH PERBEDAAN KONSENTRASI TAWAS PADA PENCELUPAN BAHAN KATUN MENGGUNAKAN ZAT WARNA ALAM EKSTRAK BUAH SENDUDUK (MELASTOMA MALABATHRICUM L)." Gorga : Jurnal Seni Rupa 8, no. 1 (2019): 260. http://dx.doi.org/10.24114/gr.v8i1.13630.
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AbstrakPenggunaan ekstrak zat warna alam sebagai pewarnaan tekstil karena menghasilkan warna yang khas dan ramah lingkungan salah satunya adalah buah senduduk (Melastoma Malabathricum L). Tujuan penelitian ini adalah mendeskripsikan nama warna (Hue), gelap terang (Value), kerataan warna serta pengaruh perbedaan konsentrasi mordan tawas terhadap kain katun pada hasil pencelupan menggunakan ekstrak buah senduduk (Melastoma Malabathricum L). Jenis penelitian ini merupakan eksperimen. Data yang digunakan adalah data primer yang bersumber dari 18 panelis, lalu diolah dan dianalisis menggunakan uji Friedman K-related sample serta menggunakan aplikasi SPSS (Statistical Product and Service Solutions) versi 18.0. Pencelupan bahan katun dengan ekstrak buah senduduk masing-masing tanpa mordan menghasilkan warna Dark Purple #5A2364 serta Value cukup terang dan kerataan warna yang rata, mordan tawas pada konsentrasi 10 gram menghasilkan warna Pompadour Purple #704664 serta Value kurang terang dan memiliki kerataan warna yang rata, mordan tawas pada konsentrasi 50 gram menghasilkan warna Pompadour Purple #7D415F serta Value cukup terang dan memiliki kerataan warna yang rata, serta mordan tawas pada konsentrasi 100 gram menghasilkan warna Cold Purple #9780B2 serta terang dan kerataan warna yang dihasilkan cukup rata. Hasil penelitian data gelap terang warna (Value) yaitu 0,000 < 0,05 yang artinya Ho ditolak. Artinya terdapat pengaruh perbedaan yang signifikan pada perbedaan mordan pada konsentrasi 10 gram, 50 gram dan 100 gram terhadap hasil pencelupan. Pada kerataan warna menunjukkan hasil 0,045 > 0,05 yang artinya Ho diterima. Artinya tidak terdapat pengaruh yang signifikan mordan tawas pada konsentrasi 10 gram, 50 gram dan 100 gram terhadap hasil pencelupan ekstrak buah senduduk menggunakan bahan katun.Kata Kunci: buah senduduk, tawas.AbstractThe use of extracts of natural dyes as textile coloring because they produce a distinctive and environmentally friendly color, one of which is senduduk (Melastoma Malabathricum L). The purpose of this study was to describe the name of color (Hue), light darkness (Value), color flatness and the effect of differences in the concentration of mordan alum on cotton cloth on the results of dyeing using senduduk fruit extract (Melastoma Malabathricum L). This type of research is an experiment. The data used are primary data sourced from 18 panelists, then the collected data is processed and analyzed using the Friedman K-related sample test and using the SPSS application (Statistical Product and Service Solutions) version 16.0. Dyeing of cotton material with senduduk fruit extract (Melastoma Malabathricum L) without a mordan each produces Dark Purple # 5A2364 and the value is quite bright and evenly colored, the mordan alum at 10 grams produces Pompadour Purple # 704664 and The value is less bright and has a flat evenness, mordan alum at a concentration of 50 grams produces Pompadour Purple # 7D415F and the value is quite bright and has a flat color evenness, and mordan alum at 100 grams produces Cold Purple # 9780B2 and the light and evenness of the resulting color is quite flat. The results of the study of dark light colors (Value) are 0,000 <0,05 which means that Ho is rejected. This means that there are significant differences in the effect of mordan on concentrations of 10 grams, 50 grams and 100 grams on the results of dyeing. The color flatness shows the results of 0.045> 0.05, which means that Ho is accepted. This means that there is no significant effect of mordan alum at concentrations of 10 grams, 50 grams and 100 grams on the results of dyeing the fruit extract of senduduk using cotton. Keywords: senduduk fruit, alum.
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Mahfud, Raudatul, Bejo Basuki, and Shanty Savitri. "Pengaruh Ekstrak Tumbuhan Melastoma malabathricum sebagai Larvasida Nabati terhadap Mortalitas Aedes aegypti L." BiosciED: Journal of Biological Science and Education 2, no. 1 (2021): 21–27. http://dx.doi.org/10.37304/bed.v2i1.2839.
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Tingginya kasus DBD di Indonesia erat kaitannya dengan peningkatan mobilitas penduduk sejalan dengan tersebarnya nyamuk Aedes aegypti L sebagai vektor yang membawa virus dengue di berbagai wilayah di Indonesia. Sehingga, perlu adanya upaya pencegahan yang bisa dilakukan seperti pembuatan larvasida nabati untuk mengurangi penyebaran atau jumlah larva nyamuk di lingkungan masyarakat. Sejalan dengan hal itu, pengembangan potensi tumbuhan lokal juga harus dilakukan. Penelitian ini bertujuan untuk mengetahui pengaruh aktivitas ekstrak tumbuhan karamunting (Melastoma malabathricum) dalam membunuh larva nyamuk Aedes aegypti L. Penelitian ini merupakan penelitian eksperimental dengan Rancangan Acak Lengkap (RAL) yang terdiri dari perlakuan P0 (kontrol negatif), P1 (kontrol positif), P2 (ekstrak batang karamunting), P3 (ekstrak daun karamunting), dan P4 (ekstrak akar karamunting) pada konsentrasi 3.5% serta terdapat 5 ulangan pada masing-masing perlakuan dengan jumlah sampel 500 larva Aedes aegypti L. Pembuatan ekstraksi simplisia batang, daun, dan akar karamunting menggunakan metode maserasi dan pelarut ethanol 70%. Hasil penelitian menunjukkan pemberian ekstrak simplisia batang, daun, dan akar tumbuhan karamunting (Melastoma malabathricum) dengan konsentrasi 3.5% pada media air tempat hidup larva mampu menyebabkan kematian yang signifikan seiring lamanya waktu pengamatan. Berdasarkan uji lanjut, diketahui bahwa perlakuan P2 yaitu pemberian ekstrak batang karamunting merupakan perlakuan terbaik dalam menyebabkan kematian larva Aedes aegypti L.
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Mayasari, Dian, Yosi Bayu Murti, Sylvia Utami Tunjung Pratiwi, and Sudarsono Sudarsono. "Antibacterial Activity and TLC-Densitometric Analysis of Secondary Metabolites in the Leaves of the Traditional Herb, Melastoma malabathricum L." Borneo Journal of Pharmacy 5, no. 4 (2022): 334–44. http://dx.doi.org/10.33084/bjop.v5i4.3818.
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Indonesia is rich in the biodiversity of medicinal plants used traditionally for healing several ailments. Melastoma malabathricum L. is one of the traditional herbs used to treat many diseases. A TLC-densitometric method was developed for determining secondary metabolites such as phenolic compounds and their related compounds, M. malabathricum leaves from Riau, Indonesia. This study investigated the secondary metabolites of M. malabathricum extract by spraying reagent: FeCl3, p-anisaldehyde, and cerium (IV) sulfate and followed by antibacterial assay through broth macro dilution method. Densitometric qualitative analysis of phenolic compounds and their related compounds was employed to examine peaks of the M. malabathricum extract through winCATS software. After spraying with particular reagents, the three extracts showed various spots/bands with several colors and exhibited peaks in TLC densitogram profiles. Three extracts were tested for antibacterial activity against Staphylococcus aureus and Escherichia coli. The result showed that ethyl acetate extract revealed excellent antibacterial activity against S. aureus and E. coli with MIC values of 3.125±0.6 mg/mL and 6.25±0.5 mg/mL, respectively. Owing to the presence of a wide variety of secondary metabolites, the leaf extract of M. malabathricum is expected to exhibit and help develop as a therapeutic agent.
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Farizah, Nuril, Muhammad Zairin JR, Latifah Kosim Darusman, Arief Boediono, and Muhammad Agus Suprayudi. "The Side Effect of the Melastoma malabathricum L Ethanol Extract on the Gonad Maturation of Female Orange Mud Crab (Scylla olivacea)." HAYATI Journal of Biosciences 25, no. 4 (2018): 188. http://dx.doi.org/10.4308/hjb.25.4.188.
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The medicinal plants in aquaculture are currently being studied quite extensively by researchers. Medicinal plants can act as an inducer or aphrodisiac and an antifertility agent in gonad maturation. The aimed of the experiment was to known side effects of the herb M. malabathricum L. on maturation process in female mud crab (S. olivacea). This study used 40 crabs with an average weight of 200-250g. The experiment consists of two treatment groups. The controls group (A) that received 100 μl of aquadest and group treatment (B) received 100 μl of 2 mg/g of ethanol extract M. malabathricum L. were studied. For 5, 10, 15, and 20 days of experiment, crabs were anesthetized and sacrified. The ovary was collect for GSI and histology. The end of experiment days (20 day), the hemolymph was collect to used ELISA assay. The result showed, significant differences in treatment group and control groups (p<0.05) in terms the macroscopic morphology of ovary, the mean GSI and the diameter of oocytes. Histological showed the influence of extract M. malabathricum L. on inhibited the ovary development compared with the control groups. Based on this results, it is concluded that ethanol extract of M. malabathricum L. leaves at a dose of 2 mg/g act as an antifertility agent for ovary maturation of S. olivacea.
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Hidayah, Muhammad Taufiq, Pratiwi Apridamayanti, and Rafika Sari. "Penentuan profil kromatografi lapis tipis teh daun senggani (Melastoma malabathricum L.)." Jurnal Cerebellum 6, no. 1 (2020): 1. http://dx.doi.org/10.26418/jc.v6i1.43343.
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Latar belakang: Teh daun senggani (Melastoma malabathricum L.) merupakan produk minuman yang dibuat dengan cara diseduh dan dibiarkan selama 15 menit, lalu diaduk sampai larut. Daun senggani menghasilkan zat yang meliputi mineral, vitamin serta asam organik yaitu asam asetat yang berfungsi sebagai tameng dari serangan bakteri patogen. Daun senggani memiliki kandungan senyawa kimia flavonoid yang berfungsi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui profil kandungan metabolit sekunder teh daun senggani menggunakan kromatografi lapis tipis (KLT) dengan perbandingan eluen air : asam asetat : butanol (A:A:B) sebagai eluen. Metode: KLT menggunakan bercak yang diperiksa di bawah sinar UV pada panjang gelombang 245 nm dan 366 nm lalu diamati secara visual kemudian bercak disemprot menggunakan pereaksi AlCl3 dan FeCl3. Hasil: Penelitian teh daun senggani diperoleh bercak senyawa flavonoid berwarna kuning dan bercak senyawa fenol berwarna hitam. Kesimpulan: Penelitian yang dilakukan dengan metode KLT menunjukkan bawa teh daun senggani mengandung senyawa flavonoid dan fenol.
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Evifania, Rini Digna, Pratiwi Apridamayanti, and Rafika Sari. "Uji parameter spesifik dan nonspesifik simplisia daun senggani (Melastoma malabathricum L.)." Jurnal Cerebellum 5, no. 4A (2020): 17. http://dx.doi.org/10.26418/jc.v6i1.43348.
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Latar belakang: Simplisia daun senggani adalah bahan alami yang berupa berupa serbuk kering daun senggani. Simplisia perlu dilakukan uji untuk menjamin mutu dan keamanan bagi konsumen, serta menjaga keseragaman khasiatnya. Penelitian ini bertujuan untuk mengetahui kualitas serbuk hasil simplisia daun senggani (Melastoma malabathricum L.) dari Pontianak, Kalimantan Barat. Metode: Uji simplisia daun senggani dilakukan dengan melihat parameter spesifik dan nonspesifik simplisia. Hasil: Hasil uji parameter spesifik yaitu uji organoleptis menunjukkan bentuk simplisia daun senggani adalah butiran kasar, berwarna coklat kehijauan, dengan rasa kelat, serta memiliki aroma yang aromatis kuat. Uji parameter nonspesifik didapatkan kadar abu total adalah sebesar 6,369% dan kadar abu tidak larut asam adalah 3,543%. Kesimpulan: Uji organoleptis dan uji kadar abu simplisia memenuhi syarat, tetapi hasil uji kadar abu tidak larut asam tidak memenuhi syarat.
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Giri, Dil Prakash, and Meena Rajbhandari. "PHYTOCHEMICAL ANALYSIS AND CONSTITUENTS OF HEXANE EXTRACT OF MELASTOMA MALABATHRICUM L." Journal of Institute of Science and Technology 23, no. 1 (2018): 18–25. http://dx.doi.org/10.3126/jist.v23i1.22150.
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Hexane, dichloromethane, ethyl acetate, methanol and 50 % aqueous methanol extracts of leaf, flower and fruit of Melastoma malabathricum were screened for the presence of different classes of phytochemicals. In phytochemical screening, ethyl acetate, methanol and 50 % aqueous methanol extracts showed the presence of phenolics and flavonoids. Glycosides were found only in the 50 % methanol extract of fruit. Free radical scavenging activity of methanol extract of leaf, flower and fruit was determined using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical. Total phenolic content was measured spectrophotometrically using Folin-Ciocalteu, total flavonoids content by using aluminum chloride and total sugar content by using anthrone reagent. Gallic acid was used as a standard for the calibration of phenolics, catechin for flavonoids and glucose for carbohydrates. The highest amount of phenolic was found in the 50 % methanol extract of leaf (242.88 ± 3.52 mg GAE/g extract), the highest amount of flavonoids was found in the ethyl acetate extract of leaf (127.41 ± 6.33 mg CE/g extract). Total sugar in 50 % methanol extract of fruit was found to be 151.12 ± 8.79 mg GE/g extract. Methanol extracts of flower showed the strongest antioxidant activity with IC50 value of 17.23 μg/ml. Silyl derivative of hexane extracts were prepared by using N-methyl-N-(trimetylsilyl) trifluoroacetamide for gas chromatography-mass spectroscopic (GC-MS) analysis. The GC-MS analysis of hexane extract allowed the identification of 17 phyto-constituents by comparing the fragmentation pattern of each component in mass spectrum with the standard NIST mass spectral database.
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Sirat, Hasnah M., Deny Susanti, Farediah Ahmad, Hiromitsu Takayama, and Mariko Kitajima. "Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L." Journal of Natural Medicines 64, no. 4 (2010): 492–95. http://dx.doi.org/10.1007/s11418-010-0431-8.
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Susanti, Deny, Hasnah M. Sirat, Farediah Ahmad, Rasadah Mat Ali, Norio Aimi, and Mariko Kitajima. "Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L." Food Chemistry 103, no. 3 (2007): 710–16. http://dx.doi.org/10.1016/j.foodchem.2006.09.011.
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Anandika Lestari, Oke, Nurheni Sri Palupi, Agus Setiyono, Feri Kusnandar, and Nancy Dewi Yuliana. "PROFIL SENSORI TEH DAUN KARAMUNTING (Melastoma malabathricum L.) DENGAN METODE SENSOMETRIK." Jurnal Teknologi Pertanian 24, no. 2 (2023): 105–16. http://dx.doi.org/10.21776/ub.jtp.2023.024.02.4.
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Daun karamunting (Melastoma malabathricum. L) dalam bentuk teh (Tisane) dipreparasi sebagai minuman merupakan salah satu upaya menangani diabetes oleh masyarakat di Kalimantan Barat. Tujuan dari penelitian ini adalah memetakan profil sensori minuman daun karamunting dan atribut sensori yang berpotensi menurunkan tingkat kesukaan dengan metode sensometrik. Teh yang diminati konsumen adalah yang tidak terlalu bitter dan kurang astringency. Metode penyeduhan dapat memberikan persepsi atribut sensori yang berbeda. Profil sensori dan hedonik tisane karamunting (Tikar) dengan berbagai metode penyeduhan dievaluasi menggunakan quantitative descriptive analysis (QDA) dan uji hedonik. Perbedaan metode penyeduhan dengan rasio daun kering:air (7:100 atau 3:100 b/v) digunakan dalam penelitian ini, yaitu seduh panas konvensional (PKV7 dan PKV3), seduh dingin (DKV7), seduh panas dengan drip bag (PDB7), dan seduh panas dengan tea bag (PTB3). Tisane komersial dalam tea bag (PTK3) digunakan sebagai pembanding. Pemetaan profil sensori hasil uji QDA pada berbagai metode penyeduhan dianalisis dengan PCA yang dilanjutkan dengan OPLS-DA dan korelasinya dengan hasil uji hedonik dianalisis dengan OPLS. Hasil dari QDA menunjukkan bahwa Tikar memiliki 14 atribut sensori. Metode sensometrik berhasil memetakan Tikar berdasarkan metode penyeduhan, yaitu PKV7 memiliki aktribut sensori harshness, stew dan astringency, sedangkan metode lainnya (DKV7, PKV7, PKV3, PTB3) greenish color, brightness color, serta fruity, dan PTK3 bitter dan smoky. Tingkat kesukaan tikar dengan metode penyeduhan PKV7 berada diantara metode penyeduhan lainnya dengan PTK3. Hasil penelitian ini menunjukkan bahwa atribut sensori bitter lebih menurunkan tingkat kesukaan dibandingkan astringency. Metode penyeduhan dapat memberikan atribut sensori yang berbeda, sehingga dapat menjadi alternatif sebagai strategi meningkatkan kesukaan.
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Samalei, Ermianus, Muhammad Zairin Jr., Odang Carman, and Muhammad Agus Suprayudi. "Evaluation of karamunting Melastoma malabathricum L leaf extract on gonad development and growth performance of tilapia Oreochromis niloticus." Jurnal Akuakultur Indonesia 20, no. 1 (2021): 1–13. http://dx.doi.org/10.19027/jai.20.1.1-13.
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The objective of this study was to determine the optimum dose of melastoma Melastoma malabathricum leaf extract that can inhibit the gonad development of Nile tilapia and increase its growth rate. This study used a completely randomized design containing five extract dose treatments (0, 0.5, 1, 2, and 4 g/kg diet doses) and three replications. The undifferentiated Nile tilapia larvae (7 days post hatching) were randomly distributed (n=30) to fifteen aquaria (100×50×50 cm3) and maintained for 112 days using a common recirculation system. The results showed that all dose treatments were not significantly different (P>0.05) in gonadosomatic index values of the D84 and D98 samplings. However, the 1 g/kg diet (D112) was significantly different (P<0.05) in all dose treatments. The final histological results (D112) showed that the 1 g/kg diet obtained the highest inhibition level of the testis and ovary developments, which were still in stage II compared to 0.5 g/kg diet (stage III) and control (stage IV and V). The highest average weight, absolute growth rate, and specific growth rate were obtained in the 1 g/kg diet dose which was significantly different (P<0.05) compared to the control. The percentage of males increased significantly (P<0.05) following the increased dose treatment fed to the fish (4 g/kg diet) with 80.12±4.67%, but the survival rate significantly decreased (P<0.05) compared to the control. The administration of 1 g/kg diet dose obtained the best dose and potential as an inhibiting agent for gonad development in Nile tilapia.
 
 Keywords: Melastoma malabathricum, gonad inhibition, cytosterol, Oreochromis niloticus
 
 ABSTRAK
 
 Tujuan dilakukan penelitian ini adalah untuk menentukan dosis optimum ekstrak daun melastoma Melastoma malabathricum yang dapat menghambat perkembangan gonad ikan nila sehingga meningkatkan laju pertumbuhan somatik dan mengevaluasi efektivitasnya sebagai agen seks reversal alami. Penelitian ini menggunakan rancangan acak lengkap yang terdiri atas lima perlakuan (dosis 0; 0,5; 1,0; 2,0; dan 4,0 g/kg pakan) dan tiga ulangan. Larva ikan nila sebelum kelamin terdiferensiasi (7 hari pascatetas) secara acak (n=30) dimasukkan ke dalam 15 buah akuarium (100×50×50 cm3) dan dipelihara selama 112 hari pada sistem resirkulasi. Hasil menunjukkan bahwa semua perlakuan tidak berbeda nyata (P>0,05) terhadap nilai GSI pada sampling D84 dan D98. Namun, perlakuan 1 g/kg pakan pada sampling D112 berbeda nyata (P<0,05) dengan semua perlakuan. Hasil histologi terakhir (D112) menunjukkan bahwa perlakuan 1 g/kg pakan mengindikasikan penghambatan perkembangan testis dan ovari yang paling besar yang masing-masing berada pada TKG II, dibandingkan dengan perlakuan 0,5 g/kg pakan (TKG III), dan dibandingkan dengan kontrol (TKG IV dan TKG V). Pengamatan terhadap bobot rata-rata, laju pertumbuhan mutlak, dan laju pertumbuhan harian tertinggi diperoleh pada perlakuan 1 g/kg pakan yang berbeda nyata (P<0,05) dibandingkan dengan kontrol. Persentase jantan meningkat secara signifikan (P<0,05) seiring meningkatnya konsentrasi ekstrak yang mencapai 80,12±4,67% pada perlakuan 4 g/kg pakan, namun tingkat kelangsungan hidup menurun secara signifikan (P<0,05) dibandingkan dengan kontrol. Pada keseluruhan parameter, pemberian ekstrak 1 g/kg pakan merupakan dosis terbaik dan potensial sebagai agen penghambat perkembangan gonad pada ikan nila.
 
 Kata kunci:Melastoma malabathricum, penghambatan gonad, sitosterol, Oreochromis niloticus
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Citrariana, Shesanthi, Yahya Febrianto, Sudarman Rahman, et al. "FORMULATION AND PHYSICAL EVALUATION OF KARAMUNTING FLOWER EXTRACT SHOOTING PREPARATION (Melastoma malabathricum L.)." Jurnal Farmasi & Sains Indonesia 7, no. 2 (2024): 86–91. https://doi.org/10.52216/jfsi.vol7no2p86-91.
Full textAbstract:
Soothing gel is a new cosmetic preparation in society with physical properties that increase the acceptability and effectiveness of therapy. Karamunting (Melastoma malabatricum L.) is a plant that is widely known in the Central Kalimantan region. Karamunting flowers contain flavonoid, alkaloid and saponin. The flavonoid in karamunting can be used as antioxidants. The aim of this research is to formulate karamunting flower extract (Melastoma malabathricum L.) as a soothing gel and evaluate the physical properties. The formulation method used variations of carbopol and HPMC with an extract concentration of 5%. Phytochemical testing of the extract was carried out using a tube test and total flavonoid using UV-Vis. The physical properties of the gel were tested in the form of organoleptic, homogeneity, viscosity and adhesion tests. The total flavonoid yield of karamunting flower extract was 21.22% w/w. Organoleptic properties: odorless aroma, brownish red color, and cool sensation on the skin. The preparation is homogeneous and has a viscosity of 200-300 dpa's and an adhesive force of 10.50-21.24 seconds. So it can be concluded that shooting gel karamunting flower extract has good physical properties.
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Diana, Vivi Euis, Eva Fadillah, and Putri Rizky. "Pemanfaatan ekstrak Ethanol buah Senduduk (Melastoma malabathricum L.) diformulasikan sebagai pewarna pada sediaan Eye Shadow Cream." Healthcaring: Jurnal Ilmiah Kesehatan 1, no. 2 (2022): 29–37. http://dx.doi.org/10.47709/healthcaring.v1i2.1678.
Full textAbstract:
Eye shadow adalah bagian dari kosmetika yang digunakan pada kelopak mata dan dibawah alis. Eye shadow merupakan salah satu jenis preparat dekoratif yang memerlukan bahan yang sangat aman dan cara pemakaian yang hati-hati karena dikenakan pada kulit dekat mata, biasanya pada kelopak mata atas Eye shadow dalam bentuk cream memiliki keuntungan mampu melekat pada permukaan tempat pemakaian dalam waktu yang cukup lama. Bentuk cream dapat memberikan efek mengkilap, berminyak, melembabkan dan mudah tersebar merata, mudah diusap dan mudah dicuci dengan air. Desain yang digunakan pada penelitian ini adalah desain penelitian eksperimental laboratorium, meliputi penyiapan sampel, pembuatan ekstrak, formulasi sediaan, pemeriksaan mutu fisik, uji iritasi terhadap sediaan, dan uji kesukaan dengan konsentrasi 7%, 9%, dan 11%. Hasil penelitian Zat warna dari ekstrak buah senduduk (Melastoma malabathricum L.) dapat diformulasikan ke dalam sediaan eye shadow sebagai pewarna alami dan memiliki susunan yang homogen, pH yang sesuai, sediaan yang stabil, daya oles, daya lekat, dan daya sebar yang baik, tidak mengiritasi, dan sangat disukai panelis. Perbedaan konsentrasi ekstrak buah senduduk (Melastoma malabathricum L.) yang diformulasikan dalam sediaan eye shadow cream memberikan pengaruh pada warna sediaan. Semakin tinggi konsentrasi ekstrak buah senduduk, maka semakin pekat pula pigmen warna pada sediaan. Kesimpulannya ekstrak buah senduduk dapat diformulasikan ke dalam sediaan eye shadow cream sebagai pewarna alami dan Semakin tinggi konsentrasi ekstrak buah senduduk, maka semakin pekat pula pigmen warna pada sediaan.
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Huang, Tse-Hung, Pei-Wen Hsieh, Tsu-Jung Chen, et al. "Melastoma malabathricum L. Suppresses Neutrophil Extracellular Trap Formation Induced by Synthetic Analog of Viral Double-Stranded RNA Associated with SARS-CoV-2 Infection." Pathogens 12, no. 2 (2023): 341. http://dx.doi.org/10.3390/pathogens12020341.
Full textAbstract:
Platelet hyper-reactivity and neutrophil extracellular trap (NET) formation contribute to the development of thromboembolic diseases for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated the pathophysiological effects of SARS-CoV-2 surface protein components and the viral double-stranded RNA (dsRNA) on platelet aggregation and NET formation. Traditional Chinese medicine (TCM) with anti-viral effects was also delineated. The treatment of human washed platelets with SARS-CoV-2 spike protein S1 or the ectodomain S1 + S2 regions neither caused platelet aggregation nor enhanced agonists-stimulated platelet aggregation. Moreover, NET formation can be induced by polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral dsRNA, but not by the pseudovirus composed of SARS-CoV-2 spike, envelope, and membrane proteins. To search for TCM with anti-NET activity, the plant Melastoma malabathricum L. which has anticoagulant activity was partially purified by fractionation. One of the fractions inhibited poly(I:C)-induced NET formation in a dose-dependent manner. This study implicates that SARS-CoV-2 structural proteins alone are not sufficient to promote NET and platelet activation. Instead, dsRNA formed during viral replication stimulates NET formation. This study also sheds new insight into using the active components of Melastoma malabathricum L. with anti-NET activity in the battle of thromboembolic diseases associated with SARS-CoV-2 infection.