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Journal articles on the topic 'Melatonin Physiological effect'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Chakravarty, Shilpa, and Syed Ibrahim Rizvi. "Day and Night GSH and MDA Levels in Healthy Adults and Effects of Different Doses of Melatonin on These Parameters." International Journal of Cell Biology 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/404591.

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The pineal secretory product melatonin (chemically, N-acetyl-5-methoxytryptamine) acts as an effective antioxidant and free-radical scavenger and plays an important role in several physiological functions such as sleep induction, immunomodulation, cardiovascular protection, thermoregulation, neuroprotection, tumor-suppression and oncostasis. Membrane lipid-peroxidation in terms of malondialdehyde (MDA) and intracellular glutathione (GSH) is considered to be a reliable marker of oxidative stress. The present work was undertaken to study the modulating effect of melatonin on MDA and GSH in human

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2

Zaminy, Arash, Iraj Ragerdi Kashani, Mohammad Barbarestani, Azim Hedayatpour, Reza Mahmoudi, Safoura Vardasbi, and Mohammad Ali Shokrgozar. "Effects of melatonin on the proliferation and differentiation of rat adipose-derived stem cells." Indian Journal of Plastic Surgery 41, no. 01 (January 2008): 08–14. http://dx.doi.org/10.1055/s-0039-1699220.

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ABSTRACT Background: Osteogenesis driven by adipose-derived stem cells (ADSCs) is regulated by physiological and pathological factors. Accumulating evidence from in vitro and in vivo experiments suggests that melatonin may have an influence on bone formation. However, little is known about the effects of melatonin on osteogenesis, which thus remains to be elucidated. This study was performed to determine whether melatonin at physiological concentrations (0.01-10 nM) could affect the in vitro proliferation and osteogenic differentiation of rat ADSCs.Materials and Methods: ADSCs were isolated fr

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Fernández-Alegre, Estela, Indira Álvarez-Fernández, Juan Carlos Domínguez, Adriana Casao, and Felipe Martínez-Pastor. "Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions." International Journal of Molecular Sciences 21, no. 8 (April 13, 2020): 2701. http://dx.doi.org/10.3390/ijms21082701.

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Bull spermatozoa physiology may be modulated by melatonin. We washed ejaculated spermatozoa free of melatonin and incubated them (4 h, 38 °C) with 0-pM, 1-pM, 100-pM, 10-nM and 1-µM melatonin in TALP-HEPES (non-capacitating) and TALP-HEPES-heparin (capacitating). This range of concentrations encompassed the effects mediated by melatonin receptors (pM), intracellular targets (nM–µM) or antioxidant activity (µM). Treatment effects were assessed as motility changes by computer-assisted sperm analysis (CASA) of motility and physiological changes by flow cytometry. Melatonin effects were more evide

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Liu, Guoyin, Bing Li, Xiuqiong Li, Yunxie Wei, Debing Liu, and Haitao Shi. "Comparative Physiological Analysis of Methyl Jasmonate in the Delay of Postharvest Physiological Deterioration and Cell Oxidative Damage in Cassava." Biomolecules 9, no. 9 (September 5, 2019): 451. http://dx.doi.org/10.3390/biom9090451.

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The short postharvest life of cassava is mainly due to its rapid postharvest physiological deterioration (PPD) and cell oxidative damage, however, how to effectively control this remains elusive. In this study, South China 5 cassava slices were sprayed with water and methyl jasmonate (MeJA) to study the effects of MeJA on reactive oxygen species, antioxidant enzymes, quality, endogenous hormone levels, and melatonin biosynthesis genes. We found that exogenous MeJA could delay the deterioration rate for at least 36 h and alleviate cell oxidative damage through activation of superoxide dismutase

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Glebezdina, N. S., A. A. Olina, I. V. Nekrasova, and E. M. Kuklina. "Molecular mechanisms of control of differentiation of regulatory t-lymphocytes by exogenous melatonin." Доклады Академии наук 484, no. 2 (April 13, 2019): 224–27. http://dx.doi.org/10.31857/s0869-56524842224-227.

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We investigated the role of epiphyseal hormone melatonin in the differentiation of naive CD4+T cells into regulatory T cells (Treg). The hormone at physiological and pharmacological concentrations inhibited Treg differentiation, decreasing both the proportion of CD4+FOXP3+ cells in the culture and the level of TGF‑β, the key cytokine for this T cell subpopulation. The inhibitory effect of exogenous melatonin was due to its interaction with the membrane receptors MT1 and MT2. At the same time, the signals realized through RORa — the nuclear receptor for melatonin — stimulated Treg formation; ho

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Iwan, Paulina, Jan Stepniak, and Malgorzata Karbownik-Lewinska. "Cumulative Protective Effect of Melatonin and Indole-3-Propionic Acid against KIO3—Induced Lipid Peroxidation in Porcine Thyroid." Toxics 9, no. 5 (April 21, 2021): 89. http://dx.doi.org/10.3390/toxics9050089.

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Iodine deficiency is the main environmental factor leading to thyroid cancer. At the same time iodine excess may also contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in salt iodization program, may increase oxidative damage to membrane lipids (lipid peroxidation, LPO) under experimental conditions, with the strongest damaging effect at KIO3 concentration of ~10 mM (corresponding to physiological iodine concentration in the thyroid). Melatonin and indole-3-propionic acid (IPA) are effective antioxidative indoles, each of which protects against KIO3-induced LPO in th

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7

Yang, Lu, Sijia Bu, Shengxue Zhao, Ning Wang, Jiaxin Xiao, Feng He, and Xuan Gao. "Transcriptome and physiological analysis of increase in drought stress tolerance by melatonin in tomato." PLOS ONE 17, no. 5 (May 17, 2022): e0267594. http://dx.doi.org/10.1371/journal.pone.0267594.

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Drought stress seriously affects tomato growth, yield and quality. Previous reports have pointed out that melatonin (MT) can alleviate drought stress damage to tomato. To better understand the possible physiological and molecular mechanisms, chlorophyll fluorescence parameters and leaf transcriptome profiles were analyzed in the “Micro Tom” tomato cultivar with or without melatonin irrigation under normal and drought conditions. Polyethylene glycol 6000 (PEG6000) simulated continuous drought treatment reduced plant height, but melatonin treatment improved plant growth rate. Physiological param

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Bigham-Sadegh, Amin. "The Effects of Melatonin in Bone Healing." Open Access Journal of Veterinary Science & Research 3, no. 2 (2018): 1–8. http://dx.doi.org/10.23880/oajvsr-16000155.

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Melatonin, an endogenous hormone, regularly is produced in pineal gland. Suprachiasmatic nucleus and the light/dark cycle controls melatonin function. Melatonin doesn't act upon specific target tissue; it reaches all organs and tissues and enters all intra cellular structures like mitochondria and nucleus. Melatonin has an important effect on physiological processes of body including regulation of blood pressure, circadian rhythms, ovarian function, seasonal reproduction, and immune function. The general ef fects of melatonin in bone health were proposed by many researchers during the last yea

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9

Raynaud, F., J. L. Miguel, B. Vivien-Roels, M. Masson-Pévet, and P. Pévet. "The effect of 5-methoxytryptamine on golden hamster gonads is not a consequence of its acetylation into melatonin." Journal of Endocrinology 121, no. 3 (June 1989): 507–12. http://dx.doi.org/10.1677/joe.0.1210507.

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ABSTRACT Radioimmunoassay and high performance liquid chromatography were used to determine if the gonadal atrophy induced by late afternoon injections of 5-methoxytryptamine (5-MT) in golden hamsters kept under long photoperiod could be due to the acetylation of this compound into melatonin. An increase in plasma concentrations of melatonin (10–13 nmol/l) was detected 15 min after injection of 130 nmol 5-MT. An injection of 4·3 nmol melatonin generated a similar plasma concentration of melatonin. 5-MT (130 nmol) and melatonin (4·3 nmol) were then injected daily in the late afternoon to golden

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10

Prada, Claudia, Susan B. Udin, Allan F. Wiechmann, and Irina V. Zhdanova. "Stimulation of Melatonin Receptors Decreases Calcium Levels in Xenopus Tectal Cells by Activating GABAC Receptors." Journal of Neurophysiology 94, no. 2 (August 2005): 968–78. http://dx.doi.org/10.1152/jn.01286.2004.

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To investigate the physiological effects of melatonin receptors in the Xenopus tectum, we have used the fluorescent indicator Fluo-4 AM to monitor calcium dynamics of cells in tectal slices. Bath application of KCl elicited fluorescence increases that were reduced by melatonin. This effect was stronger at the end of the light period than at the end of the dark period. Melatonin increased γ-aminobutyric acid-C (GABAC)–receptor activity, as demonstrated by the ability of the GABAC-receptor antagonists, picrotoxin and TPMPA, to abolish the effects of melatonin. In contrast, neither the GABAA-rece

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Song, Juhyun, So Mang Kang, Kyoung Min Lee, and Jong Eun Lee. "The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/854359.

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Stem cell therapy for tissue regeneration has several limitations in the fact that transplanted cells could not survive for a long time. For solving these limitations, many studies have focused on the antioxidants to increase survival rate of neural stem cells (NSCs). Melatonin, an antioxidant synthesized in the pineal gland, plays multiple roles in various physiological mechanisms. Melatonin exerts neuroprotective effects in the central nervous system. To determine the effect of melatonin on NSCs which is in LPS-induced inflammatory stress state, we first investigated nitric oxide (NO) produc

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Iwan, Paulina, Jan Stepniak, and Malgorzata Karbownik-Lewinska. "Pro-Oxidative Effect of KIO3 and Protective Effect of Melatonin in the Thyroid—Comparison to Other Tissues." Life 11, no. 6 (June 21, 2021): 592. http://dx.doi.org/10.3390/life11060592.

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Not only iodine deficiency, but also its excess may contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in the salt iodization program, can increase oxidative damage to membrane lipids (lipid peroxidation, LPO) under experimental conditions, with the strongest damaging effect at KIO3 concentration of ~10 mM (corresponding to physiological iodine concentration in the thyroid). Melatonin is an effective antioxidant, which protects against KIO3-induced LPO in the thyroid. This study aimed to compare the protective effects of melatonin, used in the highest achievable in vi

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Ogunkunle, Nathaniel, Friday Zakari, Felix Samuel, and Bobwealth O. Omontese. "PSI-15 Effects of Melatonin on Behavioral and Physiological Responses of Weaned Beef Calves." Journal of Animal Science 100, Supplement_3 (September 21, 2022): 234–35. http://dx.doi.org/10.1093/jas/skac247.425.

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Abstract Weaning is a stressful event often associated with changes in physiological characteristics, increased restlessness, reduced feed intake, and poor performance. This study was designed to evaluate the effects of melatonin on behavioral and physiological responses of weaned beef calves. Angus beef calves (n=36) at 7-mo of age were stratified by dam parity, body weight, calf sex and randomly allocated to receive either 24mg melatonin implants (MEL) or physiological saline (CON). A subset of calves were fitted with accelerometers on the hind leg to monitor activity levels for 7 days after

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Song, Runxian, Faujiah Nurhasanah Ritonga, Haiyang Yu, Changjun Ding, and Xiyang Zhao. "Effects of Exogenous Antioxidant Melatonin on Physiological and Biochemical Characteristics of Populus cathayana × canadansis ‘Xin Lin 1’ under Salt and Alkaline Stress." Forests 13, no. 8 (August 13, 2022): 1283. http://dx.doi.org/10.3390/f13081283.

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Salt and alkaline stress is one of the important problems restricting agricultural production and afforestation projects. This kind of stress will greatly limit the growth and development of forest trees. Recently, melatonin has been gradually realized as a strong kind of antioxidant due to its important regulatory and protective roles in the process of plant growth and development. This study takes Xin Lin 1 (Populus cathayana × canadansis ‘Xin Lin 1’) as the research object, and measures the changes of physiological indexes at different time points to verify the alleviation effect of melaton

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15

Gilad, Eli, Haim Matzkin, and Nava Zisapel. "Inactivation of Melatonin Receptors by Protein Kinase C in Human Prostate Epithelial Cells." Endocrinology 138, no. 10 (October 1, 1997): 4255–61. http://dx.doi.org/10.1210/endo.138.10.5269.

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Abstract The pineal hormone melatonin regulates seasonal reproduction and pubertal development in mammals. We recently found melatonin receptors in the human benign prostate tissue, primarily associated with the microsome-enriched fraction of the epithelial cells. In cultured benign prostate epithelial cells, melatonin, at physiological concentrations, suppressed [3H]thymidine incorporation and cGMP levels. The effects of melatonin were transient, suggesting inactivation of the receptors. In the present study, the possibility of inactivation of the prostate melatonin receptors by protein kinas

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Ancel, Caroline, Agnete H. Bentsen, Marie-Emilie Sébert, Manuel Tena-Sempere, Jens D. Mikkelsen, and Valérie Simonneaux. "Stimulatory Effect of RFRP-3 on the Gonadotrophic Axis in the Male Syrian Hamster: The Exception Proves the Rule." Endocrinology 153, no. 3 (March 1, 2012): 1352–63. http://dx.doi.org/10.1210/en.2011-1622.

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In seasonal mammals, a distinct photoneuroendocrine circuit that involves the pineal hormone melatonin tightly synchronizes reproduction with seasons. In the Syrian hamster, a seasonal model in which sexual activity is inhibited by short days, we have previously shown that the potent GnRH stimulator, kisspeptin, is crucial to convey melatonin's message; however, the precise mechanisms through which melatonin affects kisspeptin remain unclear. Interestingly, rfrp gene expression in the neurons of the dorsomedial hypothalamic nucleus, a brain region in which melatonin receptors are present in th

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Souissi, Amine, Narimen Yousfi, Rim Dabboubi, Ghaith Aloui, Monoem Haddad, and Nizar Souissi. "Effect of acute melatonin administration on physiological response to prolonged exercise." Biological Rhythm Research 51, no. 6 (February 7, 2019): 980–87. http://dx.doi.org/10.1080/09291016.2019.1573462.

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Guan, Qingyun, Zixu Wang, Jing Cao, Yulan Dong, and Yaoxing Chen. "Mechanisms of Melatonin in Obesity: A Review." International Journal of Molecular Sciences 23, no. 1 (December 25, 2021): 218. http://dx.doi.org/10.3390/ijms23010218.

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Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity eff

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Oliveira-Abreu, Klausen, Nathalia Silva-dos-Santos, Andrelina Coelho-de-Souza, Francisco Ferreira-da-Silva, Kerly Silva-Alves, Ana Cardoso-Teixeira, José Cipolla-Neto, and José Leal-Cardoso. "Melatonin Reduces Excitability in Dorsal Root Ganglia Neurons with Inflection on the Repolarization Phase of the Action Potential." International Journal of Molecular Sciences 20, no. 11 (May 28, 2019): 2611. http://dx.doi.org/10.3390/ijms20112611.

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Melatonin is a neurohormone produced and secreted at night by pineal gland. Many effects of melatonin have already been described, for example: Activation of potassium channels in the suprachiasmatic nucleus and inhibition of excitability of a sub-population of neurons of the dorsal root ganglia (DRG). The DRG is described as a structure with several neuronal populations. One classification, based on the repolarizing phase of the action potential (AP), divides DRG neurons into two types: Without (N0) and with (Ninf) inflection on the repolarization phase of the action potential. We have previo

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Sunyer-Figueres, Mercè, Jennifer Vázquez, Albert Mas, María-Jesús Torija, and Gemma Beltran. "Transcriptomic Insights into the Effect of Melatonin in Saccharomyces cerevisiae in the Presence and Absence of Oxidative Stress." Antioxidants 9, no. 10 (October 1, 2020): 947. http://dx.doi.org/10.3390/antiox9100947.

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Melatonin is a ubiquitous indolamine that plays important roles in various aspects of biological processes in mammals. In Saccharomyces cerevisiae, melatonin has been reported to exhibit antioxidant properties and to modulate the expression of some genes involved in endogenous defense systems. The aim of this study was to elucidate the role of supplemented melatonin at the transcriptional level in S. cerevisiae in the presence and absence of oxidative stress. This was achieved by exposing yeast cells pretreated with different melatonin concentrations to hydrogen peroxide and assessing the entr

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Chang, Tianliang, Yi Zhao, Hongyan He, Qianqian Xi, Jiayi Fu, and Yuwei Zhao. "Exogenous melatonin improves growth in hulless barley seedlings under cold stress by influencing the expression rhythms of circadian clock genes." PeerJ 9 (January 22, 2021): e10740. http://dx.doi.org/10.7717/peerj.10740.

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Background Melatonin is a hormone substance that exists in various living organisms. Since it was discovered in the pineal gland of cattle in 1956, the function of melatonin in animals has been roughly clarified. Nevertheless, in plants, the research on melatonin is still insufficient. Hulless barley (Hordeum vulgare L. var. nudum hook. f.) is a crop that originates from cultivated barley in the east, usually grown on the Qinghai-Tibet Plateau, becoming the most important food crop in this area. Although the genome and transcriptome research of highland barley has gradually increased recently

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Yang, Xiaolong, Yumeng Zhang, Ting Liu, Jiali Shi, Mingfang Qi, Yufeng Liu, and Tianlai Li. "Integrated Physiological, Transcriptomic, and Proteomic Analyses Reveal the Regulatory Role of Melatonin in Tomato Plants’ Response to Low Night Temperature." Antioxidants 11, no. 10 (October 19, 2022): 2060. http://dx.doi.org/10.3390/antiox11102060.

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Melatonin is a direct free radical scavenger that has been demonstrated to increase plants’ resistance to a variety of stressors. Here, we sought to examine the effect of melatonin on tomato seedlings subjected to low night temperatures using an integrated physiological, transcriptomic, and proteomic approach. We found that a pretreatment with 100 μM melatonin increased photosynthetic and transpiration rates, stomatal apertures, and peroxidase activity, and reduced chloroplast damage of the tomato plant under a low night temperature. The melatonin pretreatment reduced the photoinhibition of ph

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Kabiri, Rozita, Ali Hatami, Hakimeh Oloumi, Mehdi Naghizadeh, Fatemeh Nasibi, and Zahra Tahmasebi. "Foliar application of melatonin induces tolerance to drought stress in Moldavian balm plants (Dracocephalum moldavica) through regulating the antioxidant system." Folia Horticulturae 30, no. 1 (June 1, 2018): 155–67. http://dx.doi.org/10.2478/fhort-2018-0016.

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Abstract Melatonin, as an indoleamine molecule, regulates a wide range of physiological functions during the growth, morphogenesis and response of plants to biotic and abiotic stresses. In this research, the effect of exogenous application of melatonin (0 (distilled water), 50, 100 and 150 µM) to the leaves of Moldavian balm plants grown under different levels of drought stress (100% (control), 80%, 60% and 40% of field water capacity) was investigated. The results indicate that plants which were treated with 100 µM melatonin showed the greatest leaf surface area, lateral branching, flower len

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Rodríguez-Santana, César, Javier Florido, Laura Martínez-Ruiz, Alba López-Rodríguez, Darío Acuña-Castroviejo, and Germaine Escames. "Role of Melatonin in Cancer: Effect on Clock Genes." International Journal of Molecular Sciences 24, no. 3 (January 18, 2023): 1919. http://dx.doi.org/10.3390/ijms24031919.

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The circadian clock is a regulatory system, with a periodicity of approximately 24 h, that generates rhythmic changes in many physiological processes. Increasing evidence links chronodisruption with aberrant functionality in clock gene expression, resulting in multiple diseases, including cancer. In this context, tumor cells have an altered circadian machinery compared to normal cells, which deregulates the cell cycle, repair mechanisms, energy metabolism and other processes. Melatonin is the main hormone produced by the pineal gland, whose production and secretion oscillates in accordance wit

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Huether, G., M. Messner, A. Rodenbeck, and R. Hardeland. "Effect of continuous melatonin infusions on steady-state plasma melatonin levels in rats under near physiological conditions." Journal of Pineal Research 24, no. 3 (April 1998): 146–51. http://dx.doi.org/10.1111/j.1600-079x.1998.tb00527.x.

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Megala, R., M. K. Kalarani, P. Jeyakumar, N. Senthil, R. Pushpam, and M. Umapathi. "Standardization of optimum melatonin concentration for drought tolerance at germination and early development stage in rice (CO-54)." Journal of Applied and Natural Science 14, no. 3 (September 16, 2022): 1022–30. http://dx.doi.org/10.31018/jans.v14i3.3766.

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Drought stress poses a serious threat to production and nutritional security. In recent years, foliar application of plant growth regulators (PGRs) and nutrients are increasingly employed to overcome physiological constraints resulting in enhanced crop production. Melatonin is a new biomolecule recently found to ameliorate the effect of biotic and abiotic stresses in crop plants. Hence, the present experiment was conducted to assess the optimum concentration of melatonin to mitigate the adverse effect of drought stress on germination and growth components in rice variety CO-54. In this experim

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Baburina, Yulia, Alexey Lomovsky, and Olga Krestinina. "Melatonin as a Potential Multitherapeutic Agent." Journal of Personalized Medicine 11, no. 4 (April 6, 2021): 274. http://dx.doi.org/10.3390/jpm11040274.

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Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone produced by the pineal gland that was discovered many years ago. The physiological roles of this hormone in the body are varied. The beneficial effects of MEL administration may be related to its influence on mitochondrial physiology. Mitochondrial dysfunction is considered an important factor in various physiological and pathological processes, such as the development of neurodegenerative and cardiovascular diseases, diabetes, various forms of liver disease, skeletal muscle disorders, and aging. Mitochondrial dysfunction induces an in

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Cao, Yang, Peihua Du, Jiahao Ji, Xiaolong He, Jiran Zhang, Yuwei Shang, Huaite Liu, Jizhong Xu, and Bowen Liang. "Ionomic Combined with Transcriptomic and Metabolomic Analyses to Explore the Mechanism Underlying the Effect of Melatonin in Relieving Nutrient Stress in Apple." International Journal of Molecular Sciences 23, no. 17 (August 30, 2022): 9855. http://dx.doi.org/10.3390/ijms23179855.

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Nutrient stress harms plant growth and yield. Melatonin is a biologically active, multifunctional hormone that relieves abiotic stress in plants. Although previous studies have shown that melatonin plays an important role in improving nutrient-use efficiency, the mechanism of its regulation of nutrient stress remains unclear. In this study, melatonin was applied to apple plants under nutrient stress, and morphological indices, physiological and biochemical indices, and stomatal morphology were evaluated. The response of apple plants to nutrient deficiency and the melatonin mechanism to allevia

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Schwartz, Christine, Mallory A. Ballinger, and Matthew T. Andrews. "Melatonin receptor signaling contributes to neuroprotection upon arousal from torpor in thirteen-lined ground squirrels." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 10 (November 15, 2015): R1292—R1300. http://dx.doi.org/10.1152/ajpregu.00292.2015.

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The brain of mammalian hibernators is naturally protected. Hibernating ground squirrels undergo rapid and extreme changes in body temperature and brain perfusion as they cycle between lengthy torpor bouts and brief periods of euthermia called interbout arousals (IBAs). Arousal from torpor to IBA occurs rapidly, but there is no evidence of brain injury accompanying this extreme physiological transition. Production of the hormone melatonin accompanies arousal, suggesting that it plays a protective role at this time. Here, we investigated mechanisms of melatonin receptor-mediated protection in th

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SILALERT, Parichart, and Wattana PATTANAGUL. "Foliar application of melatonin alleviates the effects of drought stress in rice (Oryza sativa L.) seedlings." Notulae Botanicae Horti Agrobotanici Cluj-Napoca 49, no. 3 (September 3, 2021): 12417. http://dx.doi.org/10.15835/nbha49312417.

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Melatonin (N-acetyl-5-methoxytryptamine) plays an essential role in abiotic stress in plants, but its mechanism in drought tolerance is unclear. To better understand the protective roles of melatonin against drought stress, we investigated the effect of foliar application with exogenous melatonin on plant growth, physiological responses, and antioxidant enzyme activities in rice seedlings under drought stress. Rice seedlings were grown for 21 days, and foliar sprayed with 0, 50, 100, 200, and 300 µM melatonin. The control plant was watered daily, while the others were subjected to drought stre

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Wang, Shujuan, Wenju Liu, Aiyou Wen, Bing Yang, and Xunsheng Pang. "Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration." PeerJ 9 (March 8, 2021): e10627. http://dx.doi.org/10.7717/peerj.10627.

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Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia. The aim of this study was to investigate the role of high dose (10−5 M) and low dose (10−9 M) melatonin in bovine granulosa cells, and assess whether MT1 and MT2 inhibiter affect granulosa cells response to melatonin. We found that the high dose (10−5 M) and low dose (10−9 M) both could act as an essential role in modulating granulosa cells apoptosis, cell cycle and antioxidant. The beneficial effect could be relate

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Wallace, J. H., J. J. Robinson, S. Wigzell, and R. P. Aitken. "The effect of melatonin on the peripheral concentrations of LH and progesterone post-oestrus and on conception rate in ewes." Proceedings of the British Society of Animal Production (1972) 1988 (March 1988): 54. http://dx.doi.org/10.1017/s0308229600016925.

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Previous studies have shown that for Scottish Blackface ewes kept under a natural photoperiod and exposed to the ram the daily administration of the indoleamine melatonin from June onwards advanced the breeding season and appeared to increase ovulation rate and subsequent litter size (Wigzell et al., 1986). In the primate, exposure to melatonin has been shown to stimulate progesterone production by the corpus luteum in an in vivo perfusion system (Webley & Hearn, 1987). Similarly melatonin administered at physiological concentrations stimulated progesterone production by bovine and human g

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Ye, Fan, Junhong Guo, Pengfu Hou, Yongjun Wang, Fengbin Song, Peng Zhang, and Xiangnan Li. "Impacts of Melatonin on Functionalities of Constructed Wetlands for Wastewater Treatment." Land 11, no. 11 (November 11, 2022): 2022. http://dx.doi.org/10.3390/land11112022.

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Constructed wetlands (CWs) are effective wastewater treatment systems, relying on plant and substrate uptake and microbial depletion to remove pollutants. It has been reported that melatonin can promote plant growth and change the structure of microbial communities. The effects of melatonin on stress tolerance of plants have been extensively studied, while the effects of melatonin on the efficiency of wastewater treatment in constructed wetlands are rarely known. In the current study, 1 mM melatonin was added to the constructed wetland systems to determine physiological characteristics of Phra

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Kurtulmuş, Seda, and Tuğba Kök Taş. "Gıdalarda Bulunan L-Triptofan, Serotonin, Melatonin Profilleri ve Sağlık Üzerine Etkileri." Turkish Journal of Agriculture - Food Science and Technology 3, no. 11 (November 6, 2015): 877. http://dx.doi.org/10.24925/turjaf.v3i11.877-885.355.

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Nowadays, depending on the progress of science and technology, our eating habits have changed. The shape and quality of nutrition is important for human health. Especially, some food components have various effect on central nervous system such as depression, anxiety, sleep, appetite. Food constituents are transported into the central nervous system via the neutral amino acids such as phenylalanine, leucine, isoleucine, tyrosine and valine. Amino acids have an important role in human nutrition. It cannot be synthesized in the body and one of the essential amino acids that must be taken outside

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Rácz, Beáta, Michaela Dušková, Hana Jandíková, Martin Hill, Karel Vondra, and Luboslav Stárka. "How Does Energy Intake Influence the Levels of Certain Steroids?" Prague Medical Report 116, no. 4 (2015): 290–302. http://dx.doi.org/10.14712/23362936.2015.68.

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The influence of steroid hormones on food intake is well described. However, there are only a few studies on the effect of food intake on steroid levels. The study involved eight non-smoker women (average age 29.48 ± 2.99 years; average BMI 21.3 ± 1.3 kg/m2); they did not use any kind of medication affecting steroidogenesis. We analysed the influence of four various stimuli on the levels of steroid hormones and melatonin. During their follicular phase of menstrual cycle, each woman had an oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT), a standard breakfast and p

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Sarkar, Swaimanti, Aindrila Chattopadhyay, and Debasish Bandyopadhyay. "Melatonin, the advance-guard in oxidative myocardial assault instigated by exercise stress: a physiological and biochemical insight." Melatonin Research 3, no. 4 (October 9, 2020): 451–75. http://dx.doi.org/10.32794/mr11250072.

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Exercise conducted at an optimum training load is usually beneficial for the overall health of an individual. However, an unaccustomed intense exercise carried out by untrained individuals or elite athletes during over-training and/or competition-related stress often bear inevitable cardiovascular risks. Although many alterations occurring in the cardiovascular system during exercise are the results of training adaptations, sudden cardiovascular deaths reported in competitive athletes is a matter of grave concern. Several oxidative biomarkers that depict the underlying structural and functiona

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Zhao, Zi-Yan, and Yvan Touitou. "Kinetic changes of melatonin release in rat pineal perifusions at different circadian stages. Effects of corticosteroids." Acta Endocrinologica 129, no. 1 (July 1993): 81–88. http://dx.doi.org/10.1530/acta.0.1290081.

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The kinetic characteristics of melatonin release were documented in perifused pineal glands removed from rats sacrificed at six circadian stages (light/dark =12:12): three during the light phase, i.e. 3, 7 and 11 hours after light onset (HALO), and three during the dark phase, i.e. 15, 19 and 23 HALO. Whatever the circadian stage, the melatonin release decreased during the first 3–4 h and then remained fairly constant and roughly similar up to 8 h of perifusion. However, the kinetics of the release in the first 3 h differed in perifusions of pineal glands removed during the light (progressive

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Carrascal, Livia, Pedro Nunez-Abades, Antonio Ayala, and Mercedes Cano. "Role of Melatonin in the Inflammatory Process and its Therapeutic Potential." Current Pharmaceutical Design 24, no. 14 (July 13, 2018): 1563–88. http://dx.doi.org/10.2174/1381612824666180426112832.

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Melatonin is an indolamine synthesized and secreted by the pineal gland along with other extrapineal sources including immune system cells, the brain, skin and the gastrointestinal tract. Growing interest in this compound as a potential therapeutic agent in several diseases stems from its pleiotropic effects. Thus, melatonin plays a key role in various physiological activities that include regulation of circadian rhythms, immune responses, the oxidative process, apoptosis or mitochondrial homeostasis. Most of these processes are altered during inflammatory pathologies, among which neurodegener

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Zakari, Friday, Felix Samuel, Nathaniel Ogunkunle, and Bobwealth O. Omontese. "PSI-16 Effects of Melatonin on Physiological Parameters, Chute and Exit Scores in Beef Calves Exposed to Summer Heat Stress." Journal of Animal Science 100, Supplement_3 (September 21, 2022): 233–34. http://dx.doi.org/10.1093/jas/skac247.423.

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Abstract This study was designed to evaluate the effects of melatonin on rectal temperature (RT), respiratory rate (RR), heat shock protein 70 (HSP 70), growth hormone (GH), chute (CS) and exit scores (ES) in beef calves exposed to heat stress during the summer. A total of twenty (20) eight months old calves divided into 2 groups were used for the study: melatonin group (MEL, n = 10) received 24mg of melatonin, once every 28 days, and control group (CON, n = 10) did not receive any subcutaneous melatonin implant. The effect of melatonin on RT, RR, HSP 70, GH, chute (CS) and ES were evaluated b

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Yu, Yufeng, Liyuan Deng, Lu Zhou, Guanghui Chen, and Yue Wang. "Exogenous Melatonin Activates Antioxidant Systems to Increase the Ability of Rice Seeds to Germinate under High Temperature Conditions." Plants 11, no. 7 (March 25, 2022): 886. http://dx.doi.org/10.3390/plants11070886.

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High temperatures are a major concern that limit rice germination and plant growth. Although previous studies found that melatonin can promote seed germination, the physiological regulation mechanism by which exogenous melatonin mediates high temperature tolerance during rice seed germination is still largely unknown. In order to overcome these challenges, the present study investigates the effects of melatonin on the characteristics of rice seed germination as well as on antioxidant properties, under different high temperature conditions. The results show that 100 μM melatonin seed-soaking tr

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Arendt, J. "Miracle or myth? (Melatonin research)." Problems of Endocrinology 45, no. 3 (June 15, 1999): 33–35. http://dx.doi.org/10.14341/probl11768.

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Perhaps more is said about melatonin today than about any other hormone. He is considered almost a panacea for all diseases, a source of youth; in terms of US sales, it currently competes with vitamin C and aspirin. Unfortunately, the role of melatonin is excessively exaggerated, and the claims are largely unfounded or supported only by data obtained in animal experiments [1, 2]. To clarify the mechanism of action of this hormone and its relationship with physiological chronobiology, much more research is needed. In particular, it remains to be determined the most optimal time of appointment a

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Tan, Kexin, Jiangzhu Zheng, Cheng Liu, Xianghan Liu, Xiaomin Liu, Tengteng Gao, Xinyang Song, Zhiwei Wei, Fengwang Ma, and Chao Li. "Heterologous Expression of the Melatonin-Related Gene HIOMT Improves Salt Tolerance in Malus domestica." International Journal of Molecular Sciences 22, no. 22 (November 17, 2021): 12425. http://dx.doi.org/10.3390/ijms222212425.

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Melatonin, a widely known indoleamine molecule that mediates various animal and plant physiological processes, is formed from N-acetyl serotonin via N-acetylserotonin methyltransferase (ASMT). ASMT is an enzyme that catalyzes melatonin synthesis in plants in the rate-determining step and is homologous to hydroxyindole-O-methyltransferase (HIOMT) melatonin synthase in animals. To date, little is known about the effect of HIOMT on salinity in apple plants. Here, we explored the melatonin physiological function in the salinity condition response by heterologous expressing the homologous human HIO

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Ryg, Morten. "Physiological control of growth, reproduction and lactation in deer." Rangifer 6, no. 2 (June 1, 1986): 261. http://dx.doi.org/10.7557/2.6.2.657.

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The physiological mechanisms controlling the growth, lactation and reproductive cycles of cervids, and the control of allocation of energy to different organs are discussed. The growth cycle may be secondary to an appetite cycle, regulated by changes in the secretion of prolactin, gonadal steroids, and possibly unknown factors. The reproductive cycle is controlled by changes in the release at the hypothalamic hormone GnRH, and by changes in the feedback effect of gonadal steroids. These cycles are probably the result of the timing effects of nutrition and changing photoperiod on an endogenous,

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Li, Yufei, Luqian Zhang, Yufeng Yu, Hongli Zeng, Liyuan Deng, Lifei Zhu, Guanghui Chen, and Yue Wang. "Melatonin-Induced Resilience Strategies against the Damaging Impacts of Drought Stress in Rice." Agronomy 12, no. 4 (March 27, 2022): 813. http://dx.doi.org/10.3390/agronomy12040813.

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Drought is a severe abiotic stress that imposes a serious threat to rice productivity. Although previous studies have found that melatonin can promote seed germination, the physiological regulation mechanism of drought tolerance in rice seed germination mediated by exogenous melatonin is still unclear. In order to overcome these challenges, polyethylene glycol 6000 (PEG6000) at concentrations of 20% and 35% was used to simulate osmotic stress. Rice seeds were treated with different concentrations of melatonin (i.e., 0, 20, 100, and 500 μM) to study the effects on germination characteristics, g

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Zeng, Hongli, Minghao Liu, Xin Wang, Ling Liu, Huiyi Wu, Xuan Chen, Haodong Wang, Quansheng Shen, Guanghui Chen, and Yue Wang. "Seed-Soaking with Melatonin for the Improvement of Seed Germination, Seedling Growth, and the Antioxidant Defense System under Flooding Stress." Agronomy 12, no. 8 (August 15, 2022): 1918. http://dx.doi.org/10.3390/agronomy12081918.

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Flooding is the main cause of inhibited seed germination and seedling growth during the direct seeding of rice. As a growth-regulating hormone, melatonin plays an important role in promoting seed germination and enhancing plant stress resistance. However, there are still many unknown mechanisms related to the exogenous-melatonin-mediated regulation of submergence tolerance during seed germination. To overcome these challenges, this study investigated the effects of seed-soaking with different melatonin concentrations on the germination and physiological characteristics of rice seeds over diffe

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Hadi, Amir, Ehsan Ghaedi, Sajjad Moradi, Makan Pourmasoumi, Abed Ghavami, and Marzieh Kafeshani. "Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Hormone and Metabolic Research 51, no. 03 (March 2019): 157–64. http://dx.doi.org/10.1055/a-0841-6638.

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AbstractMelatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta—analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potential RCTs with information

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Al-Azawi, T. S. S., Majid H. Injidi, A. K. J. Rh,adi, and A. A. W. Habib. "The role of melatonin in maintenance of immunological internal environment." Iraqi Journal of Veterinary Medicine 27, no. 1 (June 28, 2003): 208–15. http://dx.doi.org/10.30539/ijvm.v27i1.1111.

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Melatonin hormone secretes from the pineal gland during dark period. This study was designed to investigate the effect of daily melatonin administration to chicks on some physiological parameters A total of fifty fawbro chicks of one day old were divided into two groups. The first group was given melatonin orally at a dose of 12ug/100g body weight daily for eight weeks and the other group was used as a control. During this experimental work the following parameters were studied. Daily feed and water intake, body temperature before and after melatonin administration with a general observation o

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Sasaki, Haruka, Yi Zhang, Charles W. Emala, and Kentaro Mizuta. "Melatonin MT₂ receptor is expressed and potentiates contraction in human airway smooth muscle." American Journal of Physiology-Lung Cellular and Molecular Physiology 321, no. 6 (December 1, 2021): L991—L1005. http://dx.doi.org/10.1152/ajplung.00273.2021.

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Nocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor, which couples to both Gq and Gi proteins, and the MT2 receptor, which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle; whether they regulate intracellular cyclic AMP (cAMP) and calcium concentrations ([Ca2+]i), which modulate airway smooth muscle

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Yan, Huifang, and Peisheng Mao. "Comparative Time-Course Physiological Responses and Proteomic Analysis of Melatonin Priming on Promoting Germination in Aged Oat (Avena sativa L.) Seeds." International Journal of Molecular Sciences 22, no. 2 (January 15, 2021): 811. http://dx.doi.org/10.3390/ijms22020811.

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Melatonin priming is an effective strategy to improve the germination of aged oat (Avena sativa L.) seeds, but the mechanism involved in its time-course responses has remained largely unknown. In the present study, the phenotypic differences, ultrastructural changes, physiological characteristics, and proteomic profiles were examined in aged and melatonin-primed seed (with 10 μM melatonin treatment for 12, 24, and 36 h). Thus, 36 h priming (T36) had a better remediation effect on aged seeds, reflecting in the improved germinability and seedlings, relatively intact cell ultrastructures, and enh

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Shi, Xingyun, Shanshan Xu, Desheng Mu, Ehsan Sadeghnezhad, Qiang Li, Zonghuan Ma, Lianxin Zhao, Qinde Zhang, and Lixin Wang. "Exogenous Melatonin Delays Dark-Induced Grape Leaf Senescence by Regulation of Antioxidant System and Senescence Associated Genes (SAGs)." Plants 8, no. 10 (September 23, 2019): 366. http://dx.doi.org/10.3390/plants8100366.

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Leaf senescence is a developmentally programmed and degenerative process which comprises the last stage of the life cycle of leaves. In order to understand the melatonin effect on grapevine leaf senescence, the dark treatment on detached leaves of Vitis vinifera L. cv. Red Globe was performed to induce leaf senescence at short period of time. Then, a series of physiological and molecular changes in response to exogenous melatonin were measured. Results showed that 100 μM of melatonin treatment could significantly delay the dark induced leaf senescence, which is accompanied by the decreased pro

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