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Dissertations / Theses on the topic 'Mellitic acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Nicholl, Tessa Anne. "Effect of free fatty acids and dichloroacetic acid on the diabetic isolated working rat heart." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29641.

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It is well established that a cardiomyopathy independent of atherosclerosis develops in both humans and animals with diabetes mellitus. The etiology of diabetic cardiomyopathy is very complex involving many different processes, one of which may be the increased fatty acid utilization, and/or the concomitant decrease in glucose utilization, by the diabetic heart. We compared control and 6-week streptozotocin(STZ)-induced diabetic isolated working rat hearts and were able to demonstrate cardiac dysfunction in the diabetic as assessed by depressed heart rate (HR), heart rate peak systolic pressur

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2

Martin, Nicola Catherine. "Supramolecular coordination chemistry of mellitic and pyromellitic acids." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412650.

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3

Wang, Qianyi. "Fatty Acids, Cardiovascular Diseases, and Diabetes Mellitus." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14117764.

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Cardiovascular disease (CVD) is the number one cause for mortality and morbidity around the world. Meanwhile, diabetes mellitus (DM) has become an emerging epidemic, causing 1.5 million deaths in 2012, with 80% occurring in low- and middle-income countries. Substantial evidence has linked both lifestyle and metabolic risk factors to increased risk of CVD and death, with suboptimal diet being the single leading modifiable cause of poor health (Lim. SS, et al, Lancet 2012). Of 20 top individual causes of disease burden worldwide, 8 are related to poor nutrition, including suboptimal intakes of v

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AraÃjo, Vivianne Machado de. "Study of therapeutic potential of acid caffeic protocols and diabetes in mice dyslipidemia." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12037.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>The diabetes and dyslipidemia are important in cardiovascular risk factors. When associated with oxidative stress may accelerate coronary artery disease and progression of atherosclerotic lesions. There are several natural products that stand out as potential therapeutic agents for treatment of such diseases, including caffeic acid, a phenolic compound that has a variety of biological and pharmacological activities described in the literature. Thus, the aim of this study was to evaluate the therapeutic potential of caffeic acid in e

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5

Nunes, Nara Lhays Teixeira. "Effects of Local Administration of Tiludronic Acid on Experimental Periodontitis in Diabetic Rats." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15097.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>The bisphosphonate tiludronic acid (TIL) presents anti-resorptive and anti-inflammatory properties and it has not been evaluated in the association periodontitis-diabetes mellitus (DM) to date. The purpose of this study was to evaluate the effects of local administration of TIL on experimental periodontitis (EP) in rats with streptozotocin (STZ)-induced DM. On day 1, thirty two rats received STZ injection. The animals were divided into groups (n=8): DM/C (Cont

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6

Malipa, Ana Chimuemue Antonio. "Uptake of arachidonic acid and glucose into isolated human adipocytes." Diss., University of Pretoria, 2007. http://hdl.handle.net/2263/23930.

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Both plasma glucose concentration and glucose uptake are deranged in insulin resistance. A high free fatty acid plasma level is a potential cause of insulin resistance, and therefore of type 2 diabetes mellitus animals and humans. The mechanism behind this is still unclear. The objectives of the present study were: (i) to research the effect of arachidonic acid (AA) as fatty acid representative, on glucose uptake into human isolated adipocytes, (ii) to investigate the uptake of AA into adipocyte membranes and nuclei, as a step to identify the mechanism whereby AA affects glucose uptake, and (i

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Dantas, Mariana Brito. "Betulinic acid effect in treatment of dyslipidemia and diabetes in mice." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7379.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Diabetes and dyslipidemia prevalence has been increasing globally configured as an epidemic resultant mainly from overweight, physical inactivity and genetic susceptibility. There are reports of many natural products that have hypoglycemic and hypolipidemic activity. Among them we mention the terpenes, which are the largest group of secondary products of plants metabolism. The terpene studied in this work was betulinic acid (BA), a pentacyclic triterpene lupano type that presents a variety of biological and pharmacological activiti

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8

Clebis, Naianne Kelly. "Avaliação quantitativa e morfométrica dos neurônios mioentéricos nadh-diaforase reativos do estômago de ratos diabéticos induzidos por estreptozootocina e suplementados com ácido ascórbico." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-27062007-095228/.

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A neuropatia autonômica que se manifesta em animais portadores de diabetes mellitus (DM) compromete vários órgãos. A nível gastrointestinal pode acarretar diarréia, constipação, estase e dilatação gástrica, levando a anorexia, perda de peso e vômito. Embora os mecanismos que desencadeiam esses distúrbios não estejam totalmente esclarecidos, parece que alterações do plexo mioentérico estão envolvidas. O estresse oxidativo juntamente com o aumento do sorbitol resultante das alterações metabólicas presentes no DM resultam em edema e lesão neuronal e, entre as conseqüências desta lesão, tem sido

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9

Lee, Aejin. "Investigation of the efficacy of a novel amino acid compound in the treatment of Diabetes Mellitus." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563380264792334.

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10

BOOZ, VALERIA. "Abscisic acid: a promising molecule in the treatment of type 2 diabetes mellitus and its complications." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929835.

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood sugar, insulin resistance, and relative insulin insufficiency. Being a life-long condition, T2DM exposes affected subjects to life-threatening sequelae, which typically arise one or more decades after disease onset, consisting of cardiovascular disease, stroke, and diabetic neuropathy, all sustained by the widespread damage to the microcirculation, caused by the metabolic derangement. The number of T2DM patients by 2035 is projected to reach 592 million people worldwide, rising concern among the Nationa

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11

Mooranian, Armin. "Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus." Thesis, Curtin University, 2018. http://hdl.handle.net/20.500.11937/70687.

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This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced the oral delivery resulting in greater bioavailability, tissue concentrations and glucose lowering effects in diabetic animals. Bile acids also improved the viability and activity of pancreatic β-cells within microcapsules via cellular protective effects.

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Pacheco, Paula Finkensieper. "Considerações anestésicas no paciente diabético: avaliação dos distúrbios do equilíbrio ácido-base em cães submetidos à facoemulsificação." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-09092016-152602/.

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A diabetes mellitus é uma das endocrinopatias mais frequente em cães e sabe-se que esses pacientes são mais propensos a desenvolver complicações anestésicas quando comparados aos não-diabéticos. Desta forma, objetivou-se avaliar, durante o período perioperatório, as possíveis alterações no equilíbrio ácido-base e complicações anestésicas em cães diabéticos submetidos a facoemulsificação. Foram incluídos 30 cães, sendo 15 diabéticos e 15 não portadores da afecção. Foram determinados o pH, bicarbonato e déficit de base, além de eletrólitos plasmáticos (sódio, cloro, potássio). Adicionalmente, fo

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Byrne, Christopher David. "Regulation of hepatic triacylgycerol, apolipoprotein-#beta# and lipoprotein (a) secretion by non esterified fatty acids and insulin." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259555.

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Davoren, Peter M. "The role of non-esterified fatty acids in non-insulin dependent diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323655.

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Chernatskaya, O. "The interrelation between albumin to creatinin ratio and uric acid for patients with type 2 diabetes mellitus and arterial hypertension." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/46326.

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Patients with diabetes mellitus (DM) are especially vulnerable to hypertensive injury. The coexistence with arterial hypertension (AH) has a significant impact of the poor prognosis for patients with DM because of its effect on the micro and macro vasculature.

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16

Mathavan, Sangeetha. "The applications of microencapsulated formulation of gliclazide and bile acids in Type-1 diabetes mellitus." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/59125.

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Gliclazide is used in Type 2 diabetes (T2D) to stimulate insulin production but it also has beneficial extra-pancreatic effects which make it potentially useful in T1D. In this thesis, gliclazide was formulated with different bile acids, to enhance its effects, and formed microcapsules were examined in-vitro and in-vivo. In-vitro examinations of the microcapsules included complete characterization of the microcapsules in terms of interactions between gliclazide and a primary bile acid (chenodeoxycholic acid), a secondary bile acid (taurocholic acid) and a tertiary bile acid (ursodeoxycholic ac

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Silva, Ricardo Duarte. "Avaliação dos distúrbios ácido-base e eletrolíticos de cães com cetose e cetoacidose diabética." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-20042007-122320/.

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A cetoacidose diabética (CAD) é uma das complicações mais graves do diabetes mellitus (DM) em pequenos animais. A CAD é uma emergência médica caracterizada por alterações metabólicas extremas, incluindo hiperglicemia, acidose metabólica, cetonemia, desidratação e perda de eletrólitos. Embora seja um distúrbio comum e de alta mortalidade, os padrões dos distúrbios ácido-base de cães com CAD ainda não foram avaliados objetivamente. Muitas das assunções sobre a CAD em cães são generalizadas com base em dados de pacientes humanos e estudos experimentais em cães. O objetivo do presente estudo foi

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Stefanello, Naiara. "EFEITO DO ÁCIDO CLOROGÊNICO, CAFEINA E CAFÉ EM PARÂMETROS BIOQUIMICOS E COMPORTAMENTAIS EM RATOS DIABÉTICOS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/11207.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Studies have shown that the hyperglycemia in diabetes leads to complications in cognitive, physiological and structural central nervous system (CNS) mainly linked with increased production of reactive oxygen species (ROS), which contribute to the development of chronic complications of the diabetic state. Chlorogenic acid is a phenolic compound found in coffee that presents antioxidant, neuroprotective and hypoglycemic function. In addition, caffeine is also found in high concentrations in coffee and is known for its antioxidant, n

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19

Chambers, Kathleen Mailie. "Assessment of the nutritional properties of regular and low linolenic acid canola oil in non-insulin-dependent (type II) diabetes mellitus subjects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq23244.pdf.

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Zechel, Marc A. "Characterization of immunodominant peptide determinants of glutamic acid decarboxylase relevant to insulin dependent diabetes mellitus, IDDM, in the nonobese diabetic, NOD, mouse." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28695.pdf.

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21

Bojana, Andrejić Višnjić. "Uticaj sintetske i prirodne žučne kiseline na oksidativni stres i apoptozu hepatocita." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=99738&source=NDLTD&language=en.

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Žučne kiseline (ŽK) su strukturno raznoliki molekuli, koji pored uloge koju ostvaruju putem žuči, deluju i kao signalni molekuli i ostvaruju kako endokrina tako i parakrina dejstva. Činjenica da je do sada u terapijske svrhe primenjivana samo ursodeoksiholna kiselina (UDK), posledica je brojnih ograničenja u mogućnosti primene ostalih prirodnih ŽK, i ističe potrebu za otkrivanjem novih sintetskih ŽK i liganda. Cilj istraživanja bio je ispitivanje sintetske 12-monoketoholne kiseline (MK) i prirodne UDK u modelu holestaze i aloksanom izazvanog dijabetesa. Ispitivanja su vr&scaron;ena na pacovima

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22

Hallott, Amanda Jane. "Blood cell fatty acids of pregnant women with Type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) : the influence of vitamin E supplementation alongside omega 3 and 6 fatty acids, in vitro, on LCPUGA incorporation into phospholipids and metabolism." Thesis, London Metropolitan University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549557.

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23

Maraschin, Jorge de Faria. "Acurácia diagnóstica do anticorpo anti-descarboxilase do ácido glutâmico (ANTI-GAD) como marcador de auto-imunidade no diabete melito." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/13426.

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A correta classificação do tipo de DM leva mais precocemente ao tratamento adequado e atualmente é dividida em 4 categorias: DM tipo 1, DM tipo 2, Outros tipos e Diabete Gestacional. O DM tipo 1 é geralmente auto-imune, surge em geral antes dos 20 anos de idade e é dependente de insulina para impedir a cetoacidose. O DM tipo 2 é responsável por mais de 90% dos casos, acontece em geral após os 45 anos, com história familiar e associado à síndrome metabólica. Na categoria “outros tipos”, o Maturity Onset Diabetes of the Young (MODY) é um subtipo que inicia abaixo dos 25 anos, não-dependente de i

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Spengler, Joseph R. "Diabetes-Induced Expression and Regulation of GLP-1 levels by Bile Acid Receptors (TGR5 & FXR)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4776.

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Diabetes Mellitus has continued to drastically affect the health of the world and many complications can prove fatal. As long as this metabolic disease persist, research discoveries will need to continue to be made so that patient outcomes and healthcare are dramatically enhanced. In recent years, GLP-1 has been the topic of conversation for diabetes research, due to its promising effects in promoting insulin sensitivity. Furthermore, bile acids and their receptors (TGR5 & FXR) have shown promise in their actions in the regulation of GLP-1, and thus glucose homeostasis. Here we have shown the

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Hamadeh, Mazen Jamal. "Methods for detecting abnormal adaptation to protein restriction in humans with special reference to insulin-dependent diabetes mellitus." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36948.

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Postprandial urea production in subjects with insulin dependent diabetes mellitus (IDDM) on conventional insulin therapy is normal when the previous diet is high in protein, but there is an incomplete adaptive reduction in urea production following protein restriction. To evaluate the nutritional implications of restricted protein intake in human diabetes mellitus, it is first necessary to establish a reliable method to measure changes in urea production and amino acid catabolism in response to changes in dietary protein intake. We therefore tested (1) the accuracy of the urea production rate

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Fulcher, Gregory Ronald. "The regulation of carbohydrate metabolism by fatty-acid oxidation : a study of the effects of inhibiting lipolysis in patients with non-insulin-dependent diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309822.

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Fiamoncini, Jarlei. "Efeitos de dietas com diferentes conteúdos de ácidos graxos ômega-3 no metabolismo energético - modulação da função dos peroxissomos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-21072011-160053/.

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Ácidos graxos ácidos saturados induzem resistência à insulina, enquanto ácidos graxos poliinsaturados ômega-3 previnem. Camundongos Swiss foram tratados com dieta controle e dietas contendo óleo de peixe a 4% (NFO) e 40% (HFO) ou banha de suínos a 4% (NL) e 40% (HL) por oito semanas. O grupo HFO apresentou menor massa gorda e peso corpóreo em relação ao HL. Nos grupos NFO e HFO, a insulinemia, glicemia basal e aquela durante o teste de tolerância à glicose foi menor em relação ao HL. Apesar de não haver diferenças no conteúdo de triacilgliceróis no músculo esquelético, o grupo HFO apresentou

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O'Prey, Fiona Marie. "The effects of omega-3 fatty acids on platelet and vascular reactivity in patients with type 2 diabetes mellitus hypertension." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528934.

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Jelena, Ćalasan. "Uticaj farmaceutsko-tehnološke formulacije u obliku mikrovezikula sa alginatom na resorpciju gliklazida iz digestivnog trakta pacova." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110023&source=NDLTD&language=en.

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Gliklazid je jedan od najče&scaron;će kori&scaron;ćenih lekova u terapiji dijabetes melitusa tip 2. U poslednje vreme, utvrđeno je da gliklazid ispoljava i druge pozitivne farmakolo&scaron;ke efekte kao &scaron;to su imunomodulatorni i anti-koagulacioni efekti, ukazujući na njegovu potencijalnu primenu u terapiji dijabetes melitusa tip 1. Gliklazid se odlikuje varijabilnim stepenom apsorpcije nakon peroralne primene i iz tog razloga pretpostavlja se da bi tehnike njegove ciljane isporuke, kao &scaron;to je mikroinkapsulacija, mogle da dovedu do pobolj&scaron;anja njegove apsorpcije i njegove p

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GALLI, ANGELICA. "Ruolo dei PUFA OMEGA-3 nella regolazione della funzione endoteliale in parenti di primo grado di pazienti affetti da diabete mellito di tipo 2." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2007. http://hdl.handle.net/2108/377.

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Obiettivi: La disfunzione endoteliale è il meccanismo iniziale nella patogenesi dell’aterosclerosi. Costituisce una delle alterazioni vascolari presenti in soggetti apparentemente sani parenti di primo grado di pazienti affetti da Diabete Mellito Tipo 2 (FDR). Gli acidi grassi polinsaturi n-3 (PUFA n-3), come l’acido eicosapentaenoico (EPA) e l’acido docosaesaenoico (DHA), hanno un’ampia serie di proprietà antinfiammatorie. Noi abbiamo voluto testare l’ipotesi che la somministrazione di PUFA n-3 potesse migliorare la funzione endoteliale in soggetti FDR, ad elevato rischio di sviluppare precoc

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Oliveira, Daniela Moura de. "Influência da ingestão de erva mate (Ilex paraguariensis) sobre parâmetros relacionados ao diabetes mellitus e metabolismo de glicose em ratos Wistar." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/6/6133/tde-21072008-133339/.

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Introdução: A incidencia e prevalencia do Diabetes Mellitus aumentam a cada ano, alcancando proporcoes epidemicas. A infusao aquosa de erva mate apresenta consideraveis teores de acidos clorogenicos, que alem de atuarem como antioxidantes, podem diminuir a producao e absorcao de glicose, conforme indicado na literatura. Objetivos: Avaliar a influencia da ingestao de infusao de erva mate sobre parametros bioquimicos relacionados ao diabetes mellitus e o metabolismo de glicose. Metodologia: Ratos Wistar (n=41) foram divididos em: nao diabeticos controle (NDC, n=10); nao diabeticos erva mate (NDE

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Lázari, Vanessa de Oliveira 1982. "GPR120 como mediador das ações nutrigenômicas dos ácidos graxos w3 e w9 em tecidos periféricos : controle da disfunção metabólica em animais obesos e diabéticos." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/244473.

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Orientador: Dennys Esper Corrêa Cintra<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas<br>Made available in DSpace on 2018-08-25T14:56:46Z (GMT). No. of bitstreams: 1 Lazari_VanessadeOliveira_M.pdf: 4172597 bytes, checksum: 62cbaf2cfa729f497e7b3cc4cdf3e7a1 (MD5) Previous issue date: 2013<br>Resumo: A obesidade é uma doença metabólica absolutamente fora de controle. As condições primárias associadas são hipertensão arterial, dislipidemias, diversos tipos de câncer, resistência à insulina (RI) e principalmente o diabetes mellitus tipo 2 (DM2). Den

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Quezado, Rosana. "Efeitos de suplementaÃÃo oral com mistura de Ãleos Ãmega 3; 6 e 9, com elevada relaÃÃo Ãmega 9/Ãmega 6 e baixa relaÃÃo Ãmega 6/Ãmega 3, sobre as adipocinas plasmÃticas em camundongos com Diabetes Mellitus." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9149.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O diabetes mellitus tipo 2 (DM2), doenÃa multifatorial, heterogÃnica, resulta de suscetibilidade genÃtica associada a fatores ambientais, especialmente sedentarismo e dieta rica em gorduras saturadas, e a obesidade. Caracteriza-se por resistÃncia Ã insulina (RI) e pela diminuiÃÃo da secreÃÃo desse hormÃnio. InflamaÃÃo moderada e crÃnica no tecido adiposo branco disfuncional, denominada âmeta-inflamaÃÃoâ, parece ser o elo entre obesidade, RI e DM2. Papel de adipocinas produzidas pelo tecido adiposo nessas afecÃÃes vem sendo investig

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Sadi, Gokhan. "Oxidative Damage And Regulation Of Antioxidant Enzymes In Streptozotocin Induced Diabetic Rats." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12611222/index.pdf.

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Increased oxidative stress and impaired antioxidant defense mechanisms are believed to be the important factors contributing to the pathogenesis and progression of diabetes mellitus. The products of lipid peroxidation and protein oxidation reactions were all found to be elevated significantly (p&lt<br>0.05) in diabetic animals and supplementing the animals either individually or in combination, with two powerful antioxidants DL-&amp<br>#945<br>-lipoic acid (LA) and vitamin C (VC) brought this increment toward the control values. Considering Cu-Zn SOD, CAT and GST-Mu, there was a significant de

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Pagán, Bernabeu Ana. "Estudio in vivo de la transferencia placentaria de ácidos grasos marcados con isótopos estables en sujetos con diabetes mellitus gestacional= In vivo placental transfer of fatty acids labelled with stable isotopes in gestational diabetes mellitus subjects." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/129556.

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Introducción: Los ácidos grasos poliinsaturados de cadena larga son importantes para el desarrollo neuronal del feto. Estudios observacionales sugieren que el ácido docosahexaenoico (DHA) parece estar reducido en cordón de neonatos de madres con Diabetes Mellitus Gestacional (DMG). Objetivos: estudiar in vivo, la transferencia placentaria de ácidos grasos en embarazadas con DMG utilizando isótopos estables. Material y Métodos: 11 mujeres embarazas controles y 9 con DMG recibieron oralmente 13C-ácido palmítico, 13C-ácido oléico, 13C-ácido linoléico y 13C-ácido docosahexaenoico (13C-DHA) 12h ant

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Maziah, Mohd Ghazaly Maziah. "Short chain fatty acids : the potential therapeutic target to treat high glucose-induced oxidative stress and endothelial dysfunction in type-2 diabetes mellitus." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/809543/.

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Dietary obesity, insulin resistance (IR) and type-2 diabetes mellitus (T2DM) are the major risk factors for the development of cardiovascular diseases (CVDs). Recent studies have shown that reactive oxygen species (ROS)-generating enzyme, NADPH oxidase (Nox), causes endothelial oxidative stress and is a prominent feature underlying vascular abnormalities of patients with IR and T2DM. The Nox2 has been found to be constitutively expressed in endothelial cells (ECs) and can be activated in diabetic condition. It is known that short chain fatty acids (SCFAs) i.e. acetate (NaA), propionate (NaP) a

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Krawetz, Michael D. "Comparison and characterization of immune responses elicited by peptide determinants of glutamic acid decarboxylase 65 and 67 relevant to insulin dependent diabetes mellitus, IDDM, in the nonobese diabetic, NOD, mouse." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0018/MQ58049.pdf.

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Nandrean, Simona [Verfasser], Diethelm [Akademischer Betreuer] Tschöpe, and Horst Harald [Akademischer Betreuer] Klein. "Effects of omega 3 fatty acids on vascular function in subjects with Type 2 diabetes mellitus / Simona Nandrean. Gutachter: Diethelm Tschöpe ; Horst Harald Klein." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1099703522/34.

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Alouane, Hamiroufou Loubna. "Préconditionnement myocardique et diabéte : effets aigus des AGEs sur le préconditionnement induit par la stimulation des récepteurs β1-adrénergiques et purinergiques. Rôle de la vitamine B6 (Pyridoxal-5- phosphate et pyridoxamine)". Thesis, Reims, 2012. http://www.theses.fr/2012REIMM202/document.

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Le diabète prédispose à des complications affectant divers organes comme le systémecardiovasculaire. La cardiopathie ischémique chez les patients diabétiques pourrait être liée àl'accumulation de produits avancés de glycation (AGEs). Dans les coeurs de rats ischémiques,l'expression des récepteurs aux AGEs et de ses ligands est considérablement augmentée etimpliquée dans les lésions de l'ischémie / reperfusion (I / R), même en absence de diabète. Ila été récemment rapporté que le myocarde humain diabétique ne peut pas être protégé par lepréconditionnement. Dans ce contexte, notre hypothèse étai

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Braga, Mariana Rodrigues Davanso. "Efeitos dos ácidos graxos na função de macrófagos de camundongos com diabetes tipo I induzido." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-20022018-150159/.

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O diabetes mellitus tipo I (DMI) é uma doença crônica autoimune caracterizada por hiperglicemia devido à destruição das células beta pancreáticas produtoras de insulina. Ao final de 30 dias da indução do diabetes por estreptozotocina, os macrófagos peritoneais residentes dos animais diabéticos apresentaram aumento de RNAm de citocinas e quimiocinas inflamatórias, secreção de óxido nítrico, expressão de NLRP3, iNOS e PARP1 e da atividade da via glicolítica. Perfil pró-inflamatório também foi observado em macrófagos peritoneais de animais NOD (non-obese diabetic). Camundongos diabéticos deficien

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SAITTA, FRANCESCA. "THERMODYNAMIC STABILITY OF ISG-LIKE MODEL LIPID MEMBRANES: INSPECTING THE CONTRIBUTIONS OF LIPID-LIPID INTERACTION AND ACTION OF FREE FATTY ACIDS IN THE FRAME OF TYPE 2 DIABETES MELLITUS DISEASE." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/692503.

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Allo scopo di comprendere il ruolo giocato da alcuni dei principali fattori che contribuiscono alla stabilità termodinamica delle membrane cellulari, è stato effettuato uno studio progressivo di vescicole con diversa morfologia e composizione lipidica a pH fisiologico mediante calorimetria a scansione differenziale ad alta sensibilità (High-Sensitivity DSC), raggiungendo la preparazione di vescicole lipidiche artificiali che rappresentano abbondantemente il doppio strato fosfolipidico dei granuli secretori di insulina (ISGs), vescicole presenti nelle cellule β di Langerhans del pancreas e adde

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Miranda, Wallace Rodrigues de Holanda. "Efeitos da suplementação do ácido alfa-linolênico no estresse do retículo endoplasmático em tecido adiposo subcutâneo abdominal de indivíduos com diabetes mellitus tipo 2." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-05012017-101922/.

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Diabetes mellitus tipo 2 (DM2) está associado a um estado de inflamação crônica e ativação do estresse do retículo endoplasmático (ERE). Nesse contexto, são necessários estudos para encontrar alternativas que melhorem o quadro inflamatório, como os ácidos graxos poli-insaturados ômega 3 (n-3 PUFA), um conhecido agente anti-inflamatório. Esse estudo teve por objetivo avaliar o efeito da suplementação do ácido alfa-linolênico (ALA, um n-3 PUFA) no estresse do retículo endoplasmático e no estado inflamatório no tecido adiposo subcutâneo abdominal (TASC) em pacientes com DM2. Foi conduzido um estu

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Catherman, Colin M. "Short and Long Chain Free Fatty Acids Differentially Regulate Glucagon-like Peptide-1 and Peptide YY Transcript Levels in Enteroendocrine Cells (STC-1)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4797.

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The regulation of glucagon-like peptide-1 and peptide YY hormone levels are regulated based on different influential factors, but primarily levels are dependent upon ingested food content. As meals today become more fat-enriched, there is greater requirement for evaluation of these hormones that regulate insulin and satiety levels within the body. We have shown that the gene expression transcript production of glucagon-like peptide-1 and peptide YY are modulated by different concentrations, and times of short-chain fatty acids and long-chain fatty acids. Although the peptide hormone levels

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Silva, Vera Sônia Nunes da. "Estudo dos efeitos nutricionais da farinha de polpa e mucilagem extraida do quiabo (Hibiscus esculentus L.)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254490.

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Orientador: Jaime Amaya-Farfan<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos<br>Made available in DSpace on 2018-08-05T16:53:25Z (GMT). No. of bitstreams: 1 Silva_VeraSoniaNunesda_D.pdf: 1659294 bytes, checksum: b94c247266521ad928f9d47c78675c8e (MD5) Previous issue date: 2006<br>Resumo: As fibras alimentares são entendidas como carboidratos ou substâncias poliméricas afins em alimentos que não sendo digeridas nem absorvidas no intestino superior, possuem vários efeitos fisiológicos e bioquímicos no intestino baixo e no restante do organismo, in

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Krachler, Benno. "Diet and Cardiometabolic Disease : Dietary trends and the impact of diet on diabetes and cardiovascular disease." Doctoral thesis, Umeå : Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1369.

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Stanislava, Nikolić. "Uticaj metformina na nastanak deficita vitamina B12 kod pacijenata sa tipom 2 dijabetes melitusa." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110042&source=NDLTD&language=en.

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Prema podacima iz 2011 godine, u Srbiji je približno 630 000 ljudi (8,6%) obolelo od dijabetes melitus-a, a procenjuje se da će taj broj porasti na 730 000 (10,2%) do 2030 godine. Preko 90% obolelih ima tip 2 dijabetes melitus (T2DM). Prva linija medikamentne terapije predstavljaju bigvanidi čiji je najznačajniji predstavnik metformin. Prema literaturnim podacima, u oko 10-30% sluĉajeva, kontinuirana upotreba metformina ima za posledicu smanjenu intestinalnu apsorpciju vitamina B12. Tačan patofiziolo&scaron;ki mehanizam koji dovodi do metforminom indukovane malapsorpcije vitamina B12 nije u po

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Almeida, Jussara Carnevale de. "Lipideos dietéticos em pacientes com diabetes melito tipo 2 : aspectos relacionados à nefropatia e efeitos do polimorfismo Ala54Thr do gene FABP2." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13418.

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Dragana, Bosić-Živanović. "Uticaj ftalata iz spoljašnje sredine na neke metaboličke poremećaje." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=93650&source=NDLTD&language=en.

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Uvod. Ftalati su endokrini disruptori, &scaron;iroko se koriste kao plastifikatori, rastvarači i aditivi u mnogim potro&scaron;ačkim proizvodima. Eksperimentalni podaci i humane studije sugeri&scaron;u na povezanost ftalata sa gojazno&scaron;ću i dijabetesom. Cilj. Utvrditi da li su i koji urinami metaboliti ftalata prisutni i da li postoje razlike u njihovim nivoima između bolesnika s tipom 2 &scaron;ećeme bolesti, gojaznih i kontrolne grupe zdravih osoba; da li postoji povezanost između metabolita ftalata i gojaznosti, lipida i lipoproteina seruma, glikemije, insulinemije i insulinske rezist

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Lipson, Kathryn L. "The Role of Endoplasmic Reticulum Stress Signaling in Pancreatic Beta Cells: a Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/363.

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Protein folding in the endoplasmic reticulum (ER) is essential for proper cellular function. However, the sensitive environment in the ER can be perturbed by both pathological processes as well as by physiological processes such as a large biosynthetic load placed on the ER. ER stress is a specific type of intracellular stress caused by the accumulation of immature or abnormal misfolded or unfolded proteins in the ER. Simply defined, ER stress is a disequilibrium between ER load and folding capacity. Cells have an adaptive response that counteracts ER stress called the "Unfolded Protein Respon

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Kruger, Annie J. "Prediction, Prevention and Treatment of Virally Induced Type 1 Diabetes: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/424.

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Several viral infections have been associated with human type 1 diabetes (T1D), although it has proven difficult to unequivocally establish them as causative agents. In rodent models, however, viruses have definitely been established to cause T1D. The treatment of weanling BBDR rats with the combination of a TLR3 ligand, pIC, and an ssDNA parvovirus, KRV, precipitates T1D in nearly 100% of rats within a short, predictable timeframe. In this dissertation, we utilized the BBDR rat model to (1) identify early serum biomarkers that could predict T1D precipitated by viral induction and (2) test the

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