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1

Sarlin, Annelie. "Memantin som behandling vid beteendemässiga och psykiska symtom vid demens : En litteraturstudie." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66869.

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Gerber, Rolf. "Dünnschichtchromatographische Bestimmung von Phospholipiden und Liposomale Präparate des Aminoadamantanes Memantin als Antiparkinsonmittel /." [S.l.] : [s.n.], 1992. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=9672.

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3

Antel, Maximilian [Verfasser], and Ekkehard [Akademischer Betreuer] Haen. "Memantin - Nutzen-Risiko-Bewertung unter versorgungsmedizinischen Bedingungen / Maximilian Antel. Betreuer: Ekkehard Haen." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1083252283/34.

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4

Löthgren, Maria. "Effekt och betydelse av memantin i monoterapi vid behandling av måttlig till svår Alzheimers sjukdom." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-85286.

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Introduktion: Alzheimers sjukdom (AD) är den vanligaste demenssjukdomen med ca 90 000 fall i Sverige och där 20–25 000 drabbas årligen. Sjukdomen drabbar främst äldre och prevalensen vid 65 år är 5 %. Alzheimers sjukdom orsakas av hjärnatrofi vilket kan ses som vidgade fåror och ventriklar i hjärnan, främst i pann-, hjäss- och tinninglobernas associationscortex. Tidigare troddes nedbrytningen av nervceller orsakas av degenerativa plack, främst ansamlingar av β-amyloid och av neurofibriller, men numera antas nedbrytningen orsakas av oligomerer som transporteras mellan celler och ger toxicitet.
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Caspary, Julia [Verfasser]. "Auswirkungen des NMDA-Rezeptor-Antagonisten Memantin auf die Regulation der Hochenergiephosphate im menschlichen Gehirn / Julia Caspary." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1083834355/34.

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6

Kremers, Wolfram. "Neuroprotektion durch Nikotin, Clenbuterol, Memantin und Prolin-reiches Peptid in einer Primärkultur von postnatalen Hippocampuszellen der Ratte." Aachen : Shaker, 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0435/.

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7

Lowinus, Theresa [Verfasser], Luca [Gutachter] Simeoni та Alexander [Gutachter] Marx. "Beeinflussung primärer und leukämischer T-Lymphozyten über Kᵥ1.3-Kanäle mittels Memantin / Theresa Lowinus ; Gutachter: Luca Simeoni, Alexander Marx". Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2019. http://d-nb.info/1220036218/34.

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Kremers, Wolfram [Verfasser]. "Neuroprotektion durch Nikotin, Clenbuterol, Memantin und Prolin-reiches Peptid in einer Primärkultur von postnatalen Hippocampuszellen der Ratte / Wolfram Kremers." Aachen : Shaker, 2004. http://d-nb.info/1170540031/34.

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9

Jonsson, Karl. "Are nAChRs and NMDA receptors involved in low dose ethanol-nicotine toxicity in SH-SY5Y cells?" Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-193048.

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Consumption of alcohol and tobacco is common all around the world and these drugs are frequently consumed concomitantly. It has been estimated that 70-80 % of alcoholics are smokers and non-alcoholic drinkers are more often smokers than teetotallers. Alcohol and tobacco may affect the risk of developing neurological diseases and might influence this risk differently when combined compared to when only one of these compounds is consumed. Some in vitro-research have shown that non-toxic concentrations of ethanol and nicotine, in combination, can exert toxicity, and might do so in a synergistic w
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10

Holtkamp, Johanna. "Die neuroprotektive Wirkung der NMDA-Rezeptorantagonisten CGS, Memantin und Ifenprodil, sowie Roscovitin und NMDA auf die hypoxiebedingte Zellschädigung an embryonalen kortikalen Zellen von Ratten." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-161530.

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Die vorliegende Arbeit beschäftigt sich mit dem Einfluss der NMDA-Rezeptorantagonisten, Memantin, MK-801, CGS und Ifenprodil auf die hypoxieinduzierte Zellschädigung an kortikalen Zellen der Ratte. Außerdem wurde der Einfluss von subtoxischen Konzentrationen von NMDA sowie von Roscovitin, einem Hemmer Cyclin-abhängiger Kinasen, auf die hypoxiebedingte Zellschädigung untersucht. Ziel dieser Arbeit war es, die neuroprotektive Wirkung dieser Substanzen zu erfassen. Zur Untersuchung der hypoxischen Schädigung wurden zwei 48-Well-Zellkulturplatten mit 15 Tage alten kortikalen Zellen der Ratte verw
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11

Kremers, Wolfram [Verfasser]. "Neuroprotektion durch Nikotin, Clenbuterol, Memantin und Prolin-reiches Peptid in einer Primärkultur von postnatalen Hippocampuszellen der Ratte / vorgelegt von Wolfram Alexander Kremers." Aachen : Shaker, 2004. http://nbn-resolving.de/urn:nbn:de:hebis:04-z2004-04355.

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12

Souza, Higo Fernando Santos. "Avaliação do efeito de memantina na infecção experimental pelo Trypanosoma cruzi (in vivo e in vitro)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-11042015-100453/.

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O nosso grupo está explorando como alternativa para a identificação de novas estratégias de tratamento o reposicionamento de drogas. Nesse contexto, nosso laboratório mostrou que memantina, um antagonista de receptores de glutamato NMDA, apresenta uma atividade tripanocida no ciclo de vida do T. cruzi, in vitro. Com base nessas informações, avaliamos o efeito da memantina em animais infectados com a cepa Y. O tratamento apresentou uma redução da parasitemia (40%) no 8º dpi e redução da carga parasitária no tecido cardíaco no 15º dpi. Uma vez que a cepa Y invade preferencialmente macrófagos, av
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Zimmer, Eduardo Rigon. "Efeito do pré-tratamento com memantina em um modelo de neurodegeneração induzido pela administração intrahipocampal de ácido ocadáico em ratos : uma avaliação comportamental e neuroquímica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/48982.

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A Doença de Alzheimer (DA) é uma doença cerebral progressiva que resulta em prejuízos na memória e disfunção cognitiva global. Entre as principais características neuropatológicas associadas a DA estão à presença de placas senis, emaranhados neurofibrilares e a hiperfosforilação da proteína Tau. A hiperativação do sistema glutamatérgico tem sido implicada na fisiopatologia da DA. O excesso de glutamato na fenda sináptica causa hiperativação do seu receptor ionótropico N-metill-D-aspartato (NMDA) o que favorece o aumento do influxo de cálcio e morte neuronal. A administração intracerebral de ác
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14

Schneider-Affeld, Jil Kamilla [Verfasser], Karl-Friedrich [Akademischer Betreuer] Hamann, and Elmar [Akademischer Betreuer] Oestreicher. "Die Wirkung des NMDA-Rezeptor-Antagonisten Memantin im Salicylatmodell auf die neuronale Aktivität im Hörsystem der mongolischen Wüstenrennmaus : eine 14C-2-Deoxyglukose-Studie / Jil Kamilla Schneider-Affeld. Gutachter: Karl-Friedrich Hamann ; Elmar Oestreicher. Betreuer: Elmar Oestreicher." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1013436903/34.

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15

Holtkamp, Johanna [Verfasser], Clemens [Akademischer Betreuer] Allgaier, de Arriba Susana [Akademischer Betreuer] Garcia, Hermann-Josef [Gutachter] Gertz, and Reinhard [Gutachter] Schliebs. "Die neuroprotektive Wirkung der NMDA-Rezeptorantagonisten CGS, Memantin und Ifenprodil, sowie Roscovitin und NMDA auf die hypoxiebedingte Zellschädigung an embryonalen kortikalen Zellen von Ratten / Johanna Holtkamp ; Gutachter: Hermann-Josef Gertz, Reinhard Schliebs ; Clemens Allgaier, Susana Garcia de Arriba." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239423950/34.

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16

Almeida, Rúbia Chassot de. "Estudo do efeito antidepressivo da memantina." Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102312.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.<br>Made available in DSpace on 2013-07-16T00:37:05Z (GMT). No. of bitstreams: 1 224639.pdf: 596080 bytes, checksum: 368af244964e6a68a98fad6377dcee5b (MD5)
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Malpass, Gloria Elaine McMillen Brian. "Interaction of memantine with ethanol consumption and dopaminergic function in high ethanol preferring rats." [Greenville, N.C.] : East Carolina University, 2009. http://hdl.handle.net/10342/2218.

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Thesis (Ph.D.)--East Carolina University, 2009.<br>Presented to the faculty of the Department of Pharmacology and Toxicology, the Brody School of Medicine at East Carolina University. Advisor: Brian McMillen. Title from PDF t.p. (viewed April 28, 2010). Includes bibliographical references.
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Elmore, Brandy Elizabeth. "A PRECLINICAL EVALUATION OF MEMANTINE AS A TREATMENT FOR TRAUMATIC BRAIN INJURY." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1519.

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The goal of this study was to investigate the therapeutic potential of memantine on functional recovery following a cortical contusion impact (CCI) traumatic brain injury (TBI) in a rodent model. A unilateral parietal injury was induced and compared to open sham surgeries under controlled experimental conditions. Animals were randomly assigned to a sham group, vehicle-treated injured group, or memantine-treated injured group. Dosage regimens were designed to provide serum concentrations in the range obtained with clinically approved doses, using both a low (5 mg/kg) and high (20 mg/kg) dose fo
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19

Rao, Rahul Ramesh. "The uncompetitive NMDA receptor antagonist memantine blocks compulsive eating of palatable food." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12200.

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Thesis (M.A.)--Boston University<br>Binge-eating disorder is one of the most prevalent illnesses in the U.S. today and is characterized by short periods of excessive consumption of palatable food. Our study sought to explore the role of the glutamatergic system, one of the key neural pathways associated with reward-related learning and motivation, in binge-eating. We trained male rats to consume either a highly palatable diet or a standard chow diet within a limited time frame (1 hr/day) on a fixed ratio 1 (FR1) schedule of reinforcement. The palatable- fed rats quickly developed “bingeing” be
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Kalinine, Eduardo. "Efeitos do decanoato de nandrolona na homeostasia glutamatérgica e no comportamento agressivo." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/112063.

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Nos últimos anos, houve um aumento significativo no uso abusivo dos Esteróides Anabólicos Andrógenos (EAAs). Um dos efeitos comportamentais mais marcantes da administração crônica de EAAs como o Decanoato de Nandrolona (DN) é a indução do comportamento agressivo exacerbado. Atualmente o sistema glutamatérgico tem sido associado ao comportamento agressivo induzido pelos EAAs, principalmente no que se refere à modulação dos receptores N-Methyl-D-Aspartato NMDA (NMDAr). Nós investigamos os efeitos centrais e periféricos da administração do DN ao longo do tempo (4, 11 e 19 dias consecutivos de adm
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21

Lucena, David Freitas de. "O uso da amantadina na esquizofrenia." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/49032.

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Novos tratamentos para a esquizofrenia são desejados devido a baixa resposta terapeutica dos fármacos atuais. Através de revisão sistemática da literatura e estudos anteriores realizados pelo Programa de Demências e Esquizofrenias da UFRGS, os adamantanos (memantina e amantadina), vêm mostrando-se como moléculas promissoras principalmente para pacientes refratários aos uso convencional de neurolépticos. Inicialmente são abordados os principais mecanismos neurobiológicos e fármacológicos possivelmente responsáveis pelo funcionamento da amantadina no cérebro dos pacientes tratados. O primeiro de
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Tarragón, Cros Ernesto. "Deterioro cognitivo inducido por privación de sueño : efecto de la edad y tratamiento con memantina." Doctoral thesis, Universidad de Murcia, 2013. http://hdl.handle.net/10803/119685.

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La esperanza de vida y la prevalencia de enfermedades neurodegenerativas asociadas a la edad continua in crescendo, por lo que el deterioro cognitivo asociado al envejecimiento y la perdida de memoria son problemas acuciantes en el ámbito de la salud. La memantina, antagonista de los receptores NMDA de glutamato, es un fármaco de elección en la enfermedad de Alzheimer. Los objetivos de esta tesis son, pues: i) investigar el efecto de la edad y la privación de sueño en un modelo animal de O. degus, mediante la evaluación del aprendizaje, la memoria espacial y la memoria de trabajo; ii) explorar
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Koeberle, Martin J. "Investigation of factors involved in the disposition and pharmacokinetics of memantine in the isolated bovine eye." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288743.

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Lucena, David Freitas de. "Ensaio clínico randomizado, duplo-cego, controlado por placebo, para avaliar o efeito da memantina como terapia Adjuvante no tratamento de pacientes com esquizofrenia em uso de clozap." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/26138.

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A desregulação glutamatérgica parece ter uma importante participação na neurofisiopatologia da esquizofrenia, principalmente através da disfunção do receptor NMDA. A Memantina, uma droga aprovada pelo FDA para o tratamento da doença de Alzheimer de grau moderado a severo age como um antagonista fraco e não seletivo dos receptores NMDA. O objetivo deste estudo é examinar a eficácia da memantina como tratamento adjuvante à clozapina em pacientes com esquizofrenia refratária. Métodos: Em ensaio randomizado duplo cego controlado com placebo, pacientes com esquizofrenia refratária segundo os critér
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Zenki, Kamila Cagliari. "Efeito neuroprotetor do antagonismo do receptor N-metil-D-aspartato pela memantina sobre a neurogeneração induzida pelo status epilepticus em ratos jovens." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/115047.

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O Status epilepticus induzido por LiCl-pilocarpina causa uma massiva neurodegeneração em diversas regiões cerebrais, e a maioria dos fármacos antiepilépticos clássicos não são suficientemente eficazes para proteger os neurônios da morte. Antagonistas do receptor N-metil-D-aspartato apresentam ação anticonvulsiva e são atualmente capazes de proporcionar neuroprotecção contra a morte neuronal induzida pelo SE. No entanto, estes compostos demonstraram inúmeros efeitos colaterais. Apesar disso, a memantina, um antagonista NMDA de baixa afinidade, é clinicamente bem tolerada e não induz tantos efei
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Sarwary, Mariam. "Comparison of cognitive decline medications of Alzheimer´s disease : Efficacy and safety of Donepezil, Galantamine, Rivastigmine and Memantine." Thesis, Umeå universitet, Farmakologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136250.

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27

Cordier, Mathilde. "Le recours aux soins dans la démence : la surmédicalisation en question. Exploitation des données de l’échantillon généraliste des bénéficiaires." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS201/document.

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La prise en charge de la démence est un défi pour les cliniciens tant ces patients constituent une population hétérogène. Dans le cadre de cette prise en charge, l’intérêt des antidémentiels (anticholinestérasiques et mémantine) est débattue : l’efficacité clinique semble discutable et les effets indésirables non négligeables. En 2010, des recommandations de bonnes pratiques ont laissé libre choix aux médecins de prescrire ou non ces médicaments. Depuis des questions restent en suspens : 1/ quelle est l’évolution des taux de prescription de ces médicaments depuis ces recommandations, en d’autr
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Retief, Renché. "The role of the NO-cGMP pathway as a putative target in antidepressant action / Renché Retief." Thesis, North-West University, 2004. http://hdl.handle.net/10394/731.

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Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, and appear linked to hippocampal shrinkage. Despite major advances in pharmacological treatment of the illness over the past 3040 years, currently available agents have distinct shortfalls both in clinical efficacy and in maintenance of response. This implies a greater long-term morbidity with significant impact on the patient, the patient's family as well as economic implicat
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Rimpiläinen, J. (Jussi). "Biochemical and reperfusion targeting strategies to improve brain protection during prolonged hypothermic circulatory arrest." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:951425886X.

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Abstract Ischaemic cerebral injury follows a well attested sequence of events including three phases, i.e. depolarization, biochemical cascade and reperfusion injury. Glutamate excitotoxicity plays an important role in the development of ischaemic brain injury following prolonged hypothermic circulatory arrest (HCA), and leukocyte infiltration and a cytokine-mediated inflammatory reaction are known to play a pivotal role in the reperfusion phase. The aim of this series of experimental studies was to develop biochemical and reperfusion-related strategies to improve brain protection. We tested t
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Söllmann, Carsten. "Die Wirkung des NMDA-Rezeptorantagonisten Memantine auf die Wahrnehmung von noxischen und nicht-noxischen Temperaturreizen auf der Haut beim Menschen." kostenfrei, 2008. http://nbn-resolving.de/urn/resolver.pl?urn=nbn:de:bvb:20-opus-27709.

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Dias, Caroline Pieta. "Memantina reduz o dano oxidativo em regiões cerebrais e melhora a memória de reconhecimento de longa duração em ratos velhos." Pontifícia Universidade Católica do Rio Grande do Sul, 2007. http://hdl.handle.net/10923/3611.

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Made available in DSpace on 2013-08-07T18:56:41Z (GMT). No. of bitstreams: 1 000388946-Texto+Completo-0.pdf: 352722 bytes, checksum: 42ffbc68c8b854bdcae9c51817a0368d (MD5) Previous issue date: 2007<br>Many neurodegenerative diseases, including Alzheimer’s (AD), Parkinson’s (PD) and Huntington’s diseases (HD), are caused by different mechanisms but may share a final common pathway to neuronal injury as a result of the overstimulation of glutamate receptors. It has been suggested that this pathway can be involved in generation of cognitive deficits associated with normal aging. Previous studie
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ALVES, N. C. "Modulação glutamatérgica pela memantina na memória operacional espacial em ratos sob estimulação epidural cortical por corrente contínua de baixa intensidade." Universidade Federal do Espírito Santo, 2013. http://repositorio.ufes.br/handle/10/7982.

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Made available in DSpace on 2018-08-01T22:58:44Z (GMT). No. of bitstreams: 1 tese_6508_Dissertação Natércia C. Alves.pdf: 6268019 bytes, checksum: d20074d15911b2863253c9416074bb33 (MD5) Previous issue date: 2013-05-03<br>RESUMO Paradigmas de estimulação elétrica cerebral tornaram-se uma ferramenta potencial na neuromodulação cognitiva da aprendizagem e da memória. A investigação em modelos animais translacionais no esclarecimento dos mecanismos subjacentes à neuroplasticidade faz-se necessária. A atividade de neurônios do córtex pré-frontal (CPF) é considerada como o correlato celular da me
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Feijó, Daniel Proença. "Efeito da associação de lítio e memantina na memória e neuroinflamação em um modelo animal de demência do tipo Doença de Alzheimer em ratos." reponame:Repositório Institucional da UNESC, 2017. http://repositorio.unesc.net/handle/1/5658.

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Tese de Doutorado apresentado ao Programa de Pós-Graduação em Ciências da Saúde da Universidade do Extremo Sul Catarinense para obtenção do título de Doutor em Ciências da Saúde.<br>A Doença de Alzheimer (DA) é a demência mais prevalente entre as doenças neurodegenerativas. O declínio cognitivo é a principal característica desta demência. As características fisiopatológicas incluem, acúmulo de β-amiloide1-42 (βA1-42), emaranhados neurofibrilares e neuroinflamação. Atualmente, os fármacos aprovados para doença não podem evitar a progressão desta. Portanto, o objetivo do presente estudo foi aval
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Dias, Caroline Pieta. "Memantina reduz o dano oxidativo em regi?es cerebrais e melhora a mem?ria de reconhecimento de longa dura??o em ratos velhos." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2007. http://tede2.pucrs.br/tede2/handle/tede/2761.

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Made available in DSpace on 2015-04-14T13:54:19Z (GMT). No. of bitstreams: 1 388946.pdf: 352722 bytes, checksum: 42ffbc68c8b854bdcae9c51817a0368d (MD5) Previous issue date: 2007-01-25<br>Muitas doen?as neurodegenerativas, incluindo a doen?a de Alzheimer, Parkinson e Huntington s?o causadas por diferentes mecanismos, por?m podem compartilhar uma etapa comum de dano neuronal ocasionado pela superestimula??o dos receptores glutamat?rgicos. Tem sido sugerido, que esta via pode estar envolvida no surgimento de d?ficits cognitivos associados ao envelhecimento normal. Estudos pr?vios realizados em
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Prado, Paula Andrade da Fonseca. "Avaliação do possível efeito dual (antioxidante e/ou pró-oxidante) e ação neuroprotetora do ebselen, ácido caféico e memantina em células neurais (Neuro-2A) in vitro." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-8TMKEG.

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Aging is defined by a progressive increase in many deleterious alterations in cells and tissues that enhance the risk of diseases and death. These may be due to changes in the DNA, diminution in protein synthesis, self-attack in the immune system and damage caused by oxidative reactions. Some evidences indicate that aging and chronic/degenerative diseases are primary caused by damage caused by the free radicals, including the reactive oxygen species (ROS). They may attack the most important body molecules. Oxidative stress occurs when ROS generation exceeds the antioxidant capacity of the cell
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Bothma, Tanya. "Investigating the role of the NO-cGMP pathway in an animal model of posttraumatic stress disorder (PTSD) / Tanya Bothma." Thesis, North-West University, 2004. http://hdl.handle.net/10394/477.

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Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterised by hypothalamic-pituitary-adrenal (HPA)-axis abnormalities, hyperarousal, anxiety, flashbacks of trauma memories and avoidance. Increasing evidence is now accumulating that the disorder is also associated with shrinkage of the hippocampus and cognitive dysfunction that may have its origin in stress-induced excitotoxicity. Animal studies have indeed highlighted a potential role of the excitotoxic glutamatenitric oxide (NO) pathway in the stress response. Since PTSD appears to be an illness that progresses and worsen
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Blanco, Silvente Lídia. "La relación beneficio-riesgo del tratamiento farmacológico para la enfermedad de Alzheimer." Doctoral thesis, Universitat de Girona, 2019. http://hdl.handle.net/10803/667938.

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The evidence available in the medical literature is conclusive that the risk-benefit relationship of the current medications for Alzheimer's disease is not favourable. This risk-benefit relationship is not significantly modified by any factor related to the design of the clinical trials, neither with the intervention nor with patient’s characteristics. It is also important to highlight that redundant studies that do not provide new evidence have been identified, so the realization of new clinical trials to evaluate the efficacy and safety of current medications for Alzheimer's disease would be
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38

Morel, Véronique. "Approche translationnelle de l'impact des antagonistes du récepteur NMDA (N-méthyl-D-aspartate) dans la douleur neuropathique." Thesis, Clermont-Ferrand 1, 2014. http://www.theses.fr/2014CLF1MM07.

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Les antagonistes du récepteur NMDA sont des molécules intéressantes dans la prise en charge des douleurs neuropathiques. Certaines d’entre elles, comme la kétamine, génèrent de nombreux effets indésirables, limitant leur utilisation en clinique. D’autres comme la mémantine ou le dextrométhorphane, ont fait l’objet de nombreuses études précliniques et cliniques aux résultats controversés. L’objectif de ce travail était de déterminer l’impact de ces deux molécules sur la douleur neuropathique en évaluant leurs effets antinociceptifs, cognitifs, et les événements cellulaires associés au récepteur
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39

Martin, Elodie. "Etude de l'impact des antagonistes du récepteur N-méthyl-D-aspartate (NMDA) dans la douleur neuropathique." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS012.

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Les antagonistes du récepteur N-méthyl-D-aspartate (NMDA) comme la kétamine, le dextrométhorphane et la mémantine sont utilisés pour la prise en charge de la douleur neuropathique. La kétamine est très efficace contre les douleurs neuropathiques réfractaires aux traitements conventionnels. Cependant, son utilisation est limitée du fait de nombreux effets indésirables. Un relais antalgique est alors proposé. Ce travail de thèse s’insère dans un programme de recherche dédié aux antagonistes du récepteur NMDA dans la prise en charge de la douleur neuropathique. Le premier objectif était d’évaluer
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40

Muriithi, Paul Mutuanyingi. "A case for memory enhancement : ethical, social, legal, and policy implications for enhancing the memory." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/a-case-for-memory-enhancement-ethical-social-legal-and-policy-implications-for-enhancing-the-memory(bf11d09d-6326-49d2-8ef3-a40340471acf).html.

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The desire to enhance and make ourselves better is not a new one and it has continued to intrigue throughout the ages. Individuals have continued to seek ways to improve and enhance their well-being for example through nutrition, physical exercise, education and so on. Crucial to this improvement of their well-being is improving their ability to remember. Hence, people interested in improving their well-being, are often interested in memory as well. The rationale being that memory is crucial to our well-being. The desire to improve one’s memory then is almost certainly as old as the desire to
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41

Beckmann, Holger. "Identifizierung und Charakterisierung neuer TRPC5-Kanalmodulatoren." 2019. https://ul.qucosa.de/id/qucosa%3A38379.

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Der TRPC5-Ionenkanal gehört zur Familie der transienten Rezeptorpotenzial-Kanäle und wird vorwiegend im Zentralnervensystem exprimiert. Um die Funktionsweise des Kanals besser zu verstehen, wurden in dieser Arbeit im Rahmen eines Wirkstoffscreenings die folgenden Verbindungen als neue Ionenkanalmodulatoren identifiziert und charakterisiert: Mit einer EC50 um 9 μM aktiviert das Glucocorticoid Methylprednisolon den TRPC5-Kanal. Seine, für den Konzentrationsbereich gute TRPC5-Selektivität und die Erfahrung aus jahrzehntelanger Anwendung in der Medizin machen es zu einer vielversprechenden Verbind
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42

Söllmann, Carsten. "Die Wirkung des NMDA-Rezeptorantagonisten Memantine auf die Wahrnehmung von noxischen und nicht-noxischen Temperaturreizen auf der Haut beim Menschen." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-27709.

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In der vorliegenden Studie wurde untersucht, ob der nichtkompetitive NMDA-Rezeptorantagonist Memantine die Wahrnehmung noxischer und nichtnoxischer Temperaturreize beim Menschen signifikant beeinflusst. Dazu wurden bei 40 Probanden, doppelblind und placebokontrolliert die Wahrnehmungsschwellen für Warm-, Kalt- und Hitzeschmerzreize bestimmt. Anschließend wurde ein noxischer Hitzereiz appliziert; die Schmerzintensität wurde aufgezeichnet. Danach wurden Veränderungen der Wahrnehmungsschwellen innerhalb und außerhalb des Reizareals registriert. Die Ausdehnung von Allodynie, sekundärer Hyperalgesi
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43

Kasmi, Jamil el [Verfasser]. "Auswirkungen des NMDA-Rezeptor-Antagonisten Memantin auf das Alkohol-Einnahmeverhalten adulter, alkoholerfahrener Ratten / vorgelegt von Jamil el Kasmi." 2011. http://d-nb.info/1011081148/34.

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44

Mainerová, Karolína. "Vliv memantinu a riluzolu na učení ve zvířecím modelu obsedantně-kompulzivní poruchy vyvolaném sensitizací pomocí 8-OH-DPAT." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436113.

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Obsessive-compulsive disorder is a chronic psychiatric disease. It seriously limits the quality of life of patients. Treatment of OCD is not yet fully successful and still many patients are left with debilitating symptoms without functioning medication. Animal models of genetic, behavioral, pharmacological, and optogenetic origins are beneficial in the achievement of new understandings of the disease. Chronic sensitization of serotonin 1A and 7-receptors with an agonist 8-OH-DPAT ((8- hydroxy-2-(di-propylamino)-tetralin hydrobromide) induces perseverative and compulsive behaviors, which is con
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45

Holtkamp, Johanna. "Die neuroprotektive Wirkung der NMDA-Rezeptorantagonisten CGS, Memantin und Ifenprodil, sowie Roscovitin und NMDA auf die hypoxiebedingte Zellschädigung an embryonalen kortikalen Zellen von Ratten." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13190.

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Die vorliegende Arbeit beschäftigt sich mit dem Einfluss der NMDA-Rezeptorantagonisten, Memantin, MK-801, CGS und Ifenprodil auf die hypoxieinduzierte Zellschädigung an kortikalen Zellen der Ratte. Außerdem wurde der Einfluss von subtoxischen Konzentrationen von NMDA sowie von Roscovitin, einem Hemmer Cyclin-abhängiger Kinasen, auf die hypoxiebedingte Zellschädigung untersucht. Ziel dieser Arbeit war es, die neuroprotektive Wirkung dieser Substanzen zu erfassen. Zur Untersuchung der hypoxischen Schädigung wurden zwei 48-Well-Zellkulturplatten mit 15 Tage alten kortikalen Zellen der Ratte verw
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46

Schmidt, Michaela. "Exzitotoxische Prozesse in der SIV-Enzephalitis." Doctoral thesis, 2010. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-54526.

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Die Glutamat-vermittelte Exzitotoxizität gilt als einer der wichtigsten neuropathologischen Faktoren der HIV-Demenz: Während Glutamat in physiologischer Konzentration als exzitatorischer Neurotransmitter fungiert, wirkt es in zu hoher Konzentration neurotoxisch. In vorliegender Arbeit wurde mittels Western Blotting die Proteinexpression der exzitatorischen Aminosäuretransporter EAAT1 und EAAT2 gemessen, die vor allem für den Abtransport von Glutamat aus dem synaptischen Spalt sorgen. Hierzu wurden Gehirne von mit dem simianen Immundefizienz Virus (SIV) infizierten chinesischen und indischen Rh
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47

Kerst, Steffen. "In vitro-Untersuchungen zur Beeinflussung des mikrosomalen Cytochrom P450-Systems der Rattenleber und zu möglichen oxidativen und/oder antioxidativen Eigenschaften der NMDA-Rezeptor-Antagonisten Amantadin, Memantin und Ketamin im Vergleich zu Nicanartin /." 2000. http://www.gbv.de/dms/bs/toc/321881109.pdf.

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48

Kuo, Yi-Ching, and 郭憶卿. "Determination of memantine by high performance liquid chromatographic." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/93204309572036472775.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所碩士在職專班<br>97<br>A simple,rapid and sensitive high performance liquid chromatographic method with UV detection was established for the analysis of memantine. The method is based on the derivatization of memamtine with (2-Naphthoxy) acetyl chloride (NAC) at mild conditions.This study discussed several factors of reaction, including the amounts of NAC and the reaction times, to establish the basic analysis condition for determing the quantity of commercial used memantine. This newlymethod can provide a quantitated range between 1-50 μM with detection limit on 0.03μM whe
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ZHOU, ZHANG-ZHANG, and 周献章. "Memantine facilitated the excitatory postsynaptic potential of central snail neuron." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/62314685523530504079.

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50

Nürnberg, Ingo Maximilian. "Demenzspezifische medikamentöse Behandlung mit Acetylcholinesterase-Hemmern und Memantine – Unter- und Fehlversorgung?" Doctoral thesis, 2017. https://ul.qucosa.de/id/qucosa%3A16859.

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Rezente Studien zur Versorgung von Patienten mit Antidementiva deuten auf deutliche Defizite hin. Ziel der vorliegenden Untersuchung war die Erfassung der leitliniengerechten bzw. zulassungsübergreifenden Versorgung mit Acetylcholinesterase-Hemmern (AChEI) und Memantine bei hausärztlich betreuten Alzheimer- bzw. Demenzpatienten. Des Weiteren sollten Determinanten auf ihre Assoziation mit einer Einnahme/Verschreibung von Antidementiva identifiziert werden. Die vorliegende Untersuchung basiert auf Daten, welche im Rahmen der prospektiven longitudinalen AgeCoDe-Studie (German Study on Aging, Cog
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