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Relevant bibliographies by topics / Memantine hydrochloride

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Academic literature on the topic 'Memantine hydrochloride'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Memantine hydrochloride"

1

Witt, Andrea, Nancy Macdonald, and Peter Kirkpatrick. "Memantine hydrochloride." Nature Reviews Drug Discovery 3, no. 2 (2004): 109–10. http://dx.doi.org/10.1038/nrd1311.

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2

Narola, Bhavil, A. S. Singh, P. Rita Santhakumar, and T. G. Chandrashekhar. "A Validated Stability-indicating Reverse Phase HPLC Assay Method for the Determination of Memantine Hydrochloride Drug Substance with UV-Detection Using Precolumn Derivatization Technique." Analytical Chemistry Insights 5 (January 2010): ACI.S3936. http://dx.doi.org/10.4137/aci.s3936.

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This present paper deals with the development and validation of a stability indicating high performance liquid chromatographic method for the quantitative determination of Memantine hydrochloride. Memantine hydrochloride was derivatized with 0.015 M 9-fluorenylmethyl chloroformate (FMOC) and 0.5 M borate buffer solution by keeping it at room temperature for about 20 minutes and the chromatographic separation achieved by injecting 10 μL of the derivatized mixture into a Waters HPLC system with photodiode array detector using a kromasil C18 column (150 × 4.6 mm), 5 μ, The mobile phase consisting

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3

Yegorova, A., Yu Skrypynets, I. Leonenko, G. Maltsev, S. Kashutskуy, and O. Voitiuk. "Development and Validation of HPLC-MS Method of Determination of Memantine Hydrochloride for Study of Dissolution Profiles." Methods and Objects of Chemical Analysis 16, no. 2 (2021): 71–80. http://dx.doi.org/10.17721/moca.2021.71-80.

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A method for quantitative determination of memantine hydrochloride by HPLC with mass spectrometric detection (HPLC-MS), suitable for the study of dissolution profiles of tablets "Mematon IС" was developed. Chromatographic determination was performed using a mobile phase of methanol - 0.1% (v/v) aqueous solution of formic acid (55:45) on a column of Zorbax Eclipse Plus C18 size 10 cm Ч 4.6 mm (3.5 μm) at a flow rate of 1 ml/min. The linearity interval in the appropriate dissolution media is 35 - 150 % of the normalized content of memantine hydrochloride in the tablet. The method is validated on

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4

Nguyễn, Thị Hồng Thắm, Đinh Châu Phan, Thị Hồng Thanh Nguyễn, Thị Xuân Thu Ngô, Thị Thủy Đặng, and Bình Dương Vũ. "SYNTHESIS OF MEMANTINE HYDROCHLORIDE BY DIRECT AMINOATION OF 1-BROMO-3,5-DIMETHYLADAMANTANE WITH." VietNam Military Medical Unisversity 47, no. 9 (2022): 140–48. http://dx.doi.org/10.56535/jmpm.v47i9.214.

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Objectives: To optimize the synthesis process of memantine hydrochloride by direct aminoation of 1-bromo-3,5-dimethyladamantane with urea. Materials and methods: Using the basic chemical reactions to optimize the reaction conditions. Results: The optimal conditions of the memantine hydrochloride synthesis process include: The reaction solution was diphenyl ether; the reaction temperature was 170oC within 4 hours (in the first step) and 100oC within 2 hours (in the second step); the molar ration of 1-bromo-3,5-dimethyladmantane: urea: diphenyl ether was 1:3:2.5; the duration of the reaction was

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5

Ivleva, Elena A., and Yuri N. Klimochkin. "Convenient Synthesis of Memantine Hydrochloride." Organic Preparations and Procedures International 49, no. 2 (2017): 155–62. http://dx.doi.org/10.1080/00304948.2017.1291004.

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6

Zhao, Jian, Xi Li, Xuelian Jia, and Ganke Gao. "Clinical Study on the Treatment of Senile Alzheimer’s Dementia with Sodium Oligomannate Combined with Memantine Hydrochloride." Journal of Clinical and Nursing Research 8, no. 10 (2024): 208–17. http://dx.doi.org/10.26689/jcnr.v8i10.8701.

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Objective: To analyze the clinical effects of sodium oligomannate combined with memantine hydrochloride in the treatment of senile Alzheimer’s dementia. Methods: Sixty-eight cases of Alzheimer’s dementia treated at the Second People’s Hospital of Fujian University of Traditional Chinese Medicine from March 2020 to March 2022 were selected as the study subjects. The patients were divided into two groups based on different treatment methods: the control group (treated with memantine hydrochloride, 34 cases) and the treatment group (treated with sodium oligomannate + memantine hydrochloride, 34 c

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7

Mobius, H. J., A. Stoffler, and S. M. Graham. "Memantine hydrochloride: Pharmacological and clinical profile." Drugs of Today 40, no. 8 (2004): 685. http://dx.doi.org/10.1358/dot.2004.40.8.850471.

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8

Duong Vu, Binh, Ngoc Minh Ho Ba, Hung Van Tran, and Dinh Chau Phan. "An Improved Synthesis of Memantine Hydrochloride." Organic Preparations and Procedures International 52, no. 5 (2020): 463–67. http://dx.doi.org/10.1080/00304948.2020.1785807.

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9

Dubey, Sunil K., Anil Patni, Arshad Khuroo, et al. "A Quantitative Analysis of Memantine in Human Plasma Using Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry." E-Journal of Chemistry 6, no. 4 (2009): 1063–70. http://dx.doi.org/10.1155/2009/748492.

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The aim of this study is to compare the single-dose oral bioavailability of memantine hydrochloride 10 mg tablets of Ranbaxy Laboratories Limited, with NAMENDA™ tablets (containing memantine hydrochloride 10 mg) of Forest Pharmaceuticals Inc. in healthy, adult, human subjects under fasting condition. The study was carried out as 2-way crossover design on 8 subjects in fasting and fed conditions. The plasma samples were obtained over a 72 h post dose in each period. Plasma memantine samples were analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with positive ion e

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10

Michail, Karim, Hoda Daabees, Youssef Beltagy, Magdy Abd Elkhalek, and Mona Khamis. "High-Performance Liquid Chromatographic Determination of Memantine in Human Urine Following Solid-Phase Extraction and Precolumn Derivatization." Journal of AOAC INTERNATIONAL 96, no. 6 (2013): 1302–7. http://dx.doi.org/10.5740/jaoacint.11-080.

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Abstract A validated HPLC-UV method is presented for the quantification of urinary memantine hydrochloride, a novel medication approved to treat moderate and advanced cases of Alzheimer's disease. The drug and amantadine hydrochloride, the internal standard, were extracted from human urine using SPE. The extract was then buffered and derivatized at room temperature using o-phthalaldehyde in the presence of N-acetyl-L-cyteine. Chromatographic separation of the formed derivatives was achieved on a C18 column using methanol–water mobile phase adjusted to pH 7 and pumped isocratically at 1 mL/min.

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Book chapters on the topic "Memantine hydrochloride"

1

"Memantine hydrochloride." In Cambridge Prescriber's Guide in Psychiatry. Cambridge University Press, 2023. http://dx.doi.org/10.1017/9781108986335.057.

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