Relevant bibliographies by topics / Membrane biophysics / Dissertations / Theses
To see the other types of publications on this topic, follow the link: Membrane biophysics.

Dissertations / Theses on the topic 'Membrane biophysics'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Membrane biophysics.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Fagone, Paolo. "Modulation of CCTα by membrane biophysics." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398913.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Galbraith, Toby Patrick. "Biophysical studies of membrane channel polypeptides." Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249171.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Danial, John Shokri Hanna. "Imaging lipid phase separation in droplet interface bilayers." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:34bb015f-2bc1-43bb-bc29-850e0b55edac.

Full text
Abstract:
The spatiotemporal organization of membrane proteins is implicated in cellular trafficking, signalling and reception. It was proposed that biological membranes partition into lipid rafts that can promote and control the organization of membrane proteins to localize the mentioned processes. Lipid rafts are thought to be transient (microseconds) and small (nanometers), rendering their detection a challenging task. To circumvent this problem, multi-component artificial membrane systems are deployed to study the segregation of lipids at longer time and length scales. In this thesis, multi-componen
APA, Harvard, Vancouver, ISO, and other styles
4

Bondar, Ana-Nicoleta [Verfasser]. "Computational Molecular Biophysics of Membrane Reactions / Ana-Nicoleta Bondar." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/121464144X/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Savage, David F. "Towards membrane protein structure determination." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3251931.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Liebau, Jobst. "Membrane interactions of glycosyltransferases." Licentiate thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-122485.

Full text
Abstract:
Many important biological processes occur near or in membranes. The role of membranes is not merely confined to compartmentalization, they also form the matrix for membrane associated proteins and are of functional importance. Membrane associated proteins on the other hand require specific membrane properties for proper function. The interactions between membranes and proteins are thus of paramount importance and are at the focus of this work. To draw valid conclusions about the nature of such interactions the membrane mimetics required in biophysical methods must faithfully mimic crucial prop
APA, Harvard, Vancouver, ISO, and other styles
7

Zhang, Dongmei. "Rotational motion and organization studies of cell membrane proteins." Thesis, Colorado State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10137939.

Full text
Abstract:
<p>Cell membranes are dynamic structures with complex organization. The complexity of the cell membrane arises from intrinsic membrane structure, membrane microdomains within the plasma membrane and the membrane cytoskeleton. Plasma membrane receptors are integral membrane proteins with diverse structures and functions which bind specific ligands to trigger cellular responses. Due to compartmentalization of the plasma membrane and the formation of membrane microdomains, receptors are distributed non-homogeneously in the cell membrane bilayer. Both lateral and rotational diffusion of membrane r
APA, Harvard, Vancouver, ISO, and other styles
8

Leftin, Avigdor. "Nuclear magnetic resonance probes of membrane biophysics: Structure and dynamics." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/305369.

Full text
Abstract:
The phospholipid membrane is a self-assembled, dynamic molecular system that may exist alone in association with only water, or in complex systems comprised of multiple lipid types and proteins. In this dissertation the intra- and inter-molecular forces responsible for the atomistic, molecular and collective equilibrium structure and dynamics are studied by nuclear magnetic resonance spectroscopy (NMR). The multinuclear NMR measurements and various experimental techniques are able to provide data that enable the characterization of the hierarchical spatio-temporal organization of the phospholi
APA, Harvard, Vancouver, ISO, and other styles
9

Kohram, Maryam. "A Combined Microscopy and Spectroscopy Approach to Study Membrane Biophysics." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1436530389.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Otterstrom, Jason John. "Visualizing Influenza Virus Membrane Fusion: Inhibition and Kinetics." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11251.

Full text
Abstract:
The influenza virus hemagglutinin (HA) surface protein is a primary antigenic target for neutralization of viral infection. HA also mediates membrane fusion between the virus and a cell, which is the first critical step during infection. Traditional techniques to study infection neutralization by antibodies or the membrane fusion process rely on ensemble measurements, confounding the precise mechanism of infection neutralization and obscuring transient conformational intermediates. This dissertation describes advances made in a fluorescence microscopy-based single-particle fusion assay to over
APA, Harvard, Vancouver, ISO, and other styles
11

Botelho, Ana Vitoria. "Lipid-protein interactions: Photoreceptor membrane model." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/280765.

Full text
Abstract:
G-protein coupled receptors (GPCRs) are transmembrane proteins capable of recognizing an astonishing variety of biological signals, ranging from photons of light to hormones, odorants, and neurotransmitters involved in key biological signaling processes. The aim of this work is to identify how lipid-protein interactions involving the membrane bilayer ultimately affect such vital biological functions. Here the relationship between the bilayer thickness, hydrophobic mismatch, and protein aggregation are investigated by expanding the framework of membrane-receptor interactions in terms of a new f
APA, Harvard, Vancouver, ISO, and other styles
12

Sergeev, Mikhail. "Measurement of oligomerization states of membrane proteins via spatial fluorescence intensity fluctuation analysis." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96703.

Full text
Abstract:
The objective of this thesis is the development and use of a novel fluorescence fluctuation technique for determining the oligomeric state of fluorescently labeled proteins in situ via microscopy imaging. High order moment analysis of fluorescence intensity fluctuations from individual confocal laser scanning microscopy (CLSM) images applied to study monomer-oligomer distributions of fluorescently labeled proteins was developed. Using computer simulations and experiments with fluorescent microspheres and organic fluorescent dyes, the detection limits and accuracy of this statistical approach w
APA, Harvard, Vancouver, ISO, and other styles
13

Wang, Yin 1951. "Influences of membrane biophysical properties on the Metarhodopsin I to Metarhodopsin II transition in visual excitation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282520.

Full text
Abstract:
Current biophysical studies of membrane proteins are centered on the relation of their structures to key biological functions of membranes in terms of lipid-protein interactions. The conformational transition of rhodopsin from Metarhodopsin I to Metarhodopsin II (Meta I-Meta II) is the triggering event for the visual process. Meta II is the activated form of the visual receptor and binds a signal transducing G protein (transducin), followed by two amplification stages which lead to generation of a visual nerve impulse. Herein, flash photolysis and surface plasmon resonance (SPR) spectroscopy t
APA, Harvard, Vancouver, ISO, and other styles
14

Storti, Barbara. "Interlaced biophysical methods to unveil membrane receptor organization." Doctoral thesis, Scuola Normale Superiore, 2016. http://hdl.handle.net/11384/86202.

Full text
Abstract:
From the introduction: "In my thesis I set out to address these issues by a toolbox of fluorescence imaging techniques such as Förster Resonance Energy Transfer, Fluorescence Anisotropy Imaging, and Spatio-temporal image correlation spectroscopy. I investigated receptor properties such as membrane mobility, microtubule and caveolin-1 binding, and TRPV1 oligomerization status. My experimental strategies benefited from the use of genetically-encodable fluorescent reporters belonging to the green fluorescent protein family."
APA, Harvard, Vancouver, ISO, and other styles
15

Bradshaw, Niels Raab. "Coordination of cotranslational protein targeting to the membrane." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359542.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Ranatunga, Kishani M. "Computational studies of ion channel permeation and selectivity." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325774.

Full text
APA, Harvard, Vancouver, ISO, and other styles
17

Newby, Zachary Eric Robert. "The pursuit of membrane protein structures and the malarial aquaglyceroporin pfAQP." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339213.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Stevens, Edward Benedict. "An electrophysiological study of voltage gated membrane currents in rat and mouse thymic nurse cells." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299239.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

Dahan, David. "Biophysics of porin, the major outer membrane protein of Haemophilus influenzae type b." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0025/NQ29916.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
20

Dahan, David. "Biophysics of porin : the major outer membrane protein of Haemophilus influenzae type b." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42009.

Full text
Abstract:
Haemophilus influenzae type b (Hib) is a Gram-negative bacterium that causes meningitis in infants. Located in the outer membrane, Hib porin (342 amino acids, M$ rm sb{r}$ 37,782 daltons) forms channels that allow for the diffusion into the periplasm of small solutes up to a molecular mass of 1400 daltons.<br>Based on predictions of porin secondary structure, a model of Hib porin was generated. The model proposed sixteen membrane spanning $ beta$-strands connected by eight long loops on one side and eight short $ beta$-turns on the other side. To refine further this model, the epitopes of nine
APA, Harvard, Vancouver, ISO, and other styles
21

Mudumbi, Krishna Chaitanya. "NUCLEAR ENVELOPE TRANSMEMBRANE PROTEIN DISTRIBUTION AND TRANSPORT STUDIED BY SINGLE-MOLECULE MICROSCOPY." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/489984.

Full text
Abstract:
Biology<br>Ph.D.<br>The nucleus of eukaryotic cells is a vitally important organelle that sequesters the genetic information of the cell, and protects it with the help of two highly evolved structures, the nuclear envelope (NE) and nuclear pore complexes (NPCs). Together, these two structures mediate the bidirectional trafficking of molecules between the nucleus and cytoplasm by forming a barrier. NE transmembrane proteins (NETs) embedded in either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM) play crucial roles in both nuclear structure and functions, including: genome
APA, Harvard, Vancouver, ISO, and other styles
22

Xu, Yuanda. "Thermodynamic and Hydrodynamic Coupling Effects on Compositional Lipid Domains in Membrane Stack Systems." Thesis, Princeton University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10642189.

Full text
Abstract:
<p> This dissertation will focus on my work in biophysics, and my work in mean field games and glucose predictive analysis will not be presented. Several problems relating to the effects of thermodynamic coupling and hydrodynamic coupling within the membrane stack system are discussed. Three theoretical approaches are employed and proposed to study the membrane stack system: a diffuse-interface approach is utilized for numerical simulations; a coarse-grained sharp-interface approach is utilized to provide physical understanding of various kinetics; a hybrid intermediate sharp-interface approac
APA, Harvard, Vancouver, ISO, and other styles
23

Hartsel, Scott Clifton. "Effect of membrane supramolecular structure on the photoresponse and structural stability of bacteriorhodopsin /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260531954914.

Full text
APA, Harvard, Vancouver, ISO, and other styles
24

Orwick, Marcella Christine. "Biophysical and magnetic resonance studies of membrane proteins." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e7974f5f-a5ab-4867-aa5f-feff99716c0f.

Full text
Abstract:
Bacteriorhodopsin (bR) is a 7TM membrane protein expressed in Halobacterium salinarum. Due to its stability and high expression levels, bR serves as a model for other 7TM membrane proteins. Neurotensin receptor 1 (NTS1) is a member of pharmacologically relevant G protein-coupled receptor superfamily, and is the high affinity receptor for neurotensin, a 13mer peptide that can be found in the brain, gut, and central nervous system. NTS1 is a target for Parkinson’s, Schizophrenia, and drug addiction. This thesis aims to develop pulsed magnetic resonance techniques and sample preparation forms for
APA, Harvard, Vancouver, ISO, and other styles
25

Schmidt, Bernd Ulrich Sebastian. "ACCESSING NOVEL MATERIAL PARAMETERS IN SINGLE CELL BIOMECHANICS." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-191917.

Full text
Abstract:
Die mechanischen Eigenschaften von Zellen charakterisieren und beeinflussen deren Zustand. Die vorliegende Arbeit zielt auf ein besseres Verständnis der biomechanischen Eigenschaften von Zellen ab. Der Fokus lag dabei auf der Biegesteifigkeit von Zellmembranen und der Deformierbarkeit der Zellen. Es werden drei Studien vorgestellt in der diese Materialparameter untersucht wurden. Die erste Studie befasst sich mit der Temperaturabhängigkeit der mechanischen Eigenschaften. Hierbei wurden acht verschieden Zelllienien bei jeweils fünf Temperaturen rheologisch vermessen. Zur Messung wurde der sog.
APA, Harvard, Vancouver, ISO, and other styles
26

Rieth, Monica D. "Investigating Detergent and Lipid Systems for the Study of Membrane Protein Interactions| Characterizing Caveolin Oligomerization." Thesis, Lehigh University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3638680.

Full text
Abstract:
<p> Membrane proteins represent an important class of proteins that closely associate or reside within the plasma membrane of the cell. They play a multitude of roles in cell function such as signaling, trafficking, and recently discovered, scaffolding and shaping of the plasma membrane itself. For example, caveolin is a membrane protein that is believed to have the ability to curve the plasma membrane forming invaginations that serve as signaling platforms called caveolae. The curvature of the plasma membrane is believed to be a result of caveolin oligomerization. Caveolin oligomerization was
APA, Harvard, Vancouver, ISO, and other styles
27

Dijkman, Patricia M. "Biophysical studies of membrane protein structure and function." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ad0fde85-c4b6-48a1-b51b-d304aca45402.

Full text
Abstract:
Membrane proteins play a key role in numerous physiological processes such as transport, energy transduction in respiratory and photosynthetic systems, and signal transduction, and are of great pharmaceutical interest, comprising more than 60&percnt; of known drug targets. However, crystallisation of membrane proteins, and G protein-coupled receptors (GPCRs) in particular, still relies heavily on the use of protein engineering strategies, which have been shown to hamper protein activity. Here, a range of biophysical methods were used to study the structure and function of two membrane proteins
APA, Harvard, Vancouver, ISO, and other styles
28

Barberi, Luca. "Inferring forces from geometry in biology." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS438.

Full text
Abstract:
Des forces intermoléculaires sur lesquelles nous avons peu de connaissances préalables sont souvent essentielles à la stabilité et à l'évolution des assemblages biologiques. Dans cette thèse, nous nous concentrons sur deux de ces forces qui sont impliquées de façon critique dans la déformation soit des biopolymères, soit des membranes. Nous déduisons ces forces en conciliant la géométrie d'une telle déformation avec des modèles mécaniques simples. Dans la première partie de la thèse, nous examinons la force d'attraction entre les molécules d'ADN médiées par des cations multivalents. Cette attr
APA, Harvard, Vancouver, ISO, and other styles
29

Gibson, Nicholas James. "An analysis of the secondary and tertiary structure of the membrane protein bacteriorhodopsin and changes induced by glucose or reduction of the retinal-lysine linkage /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487588939088242.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Ferguson, Joshua Paul. "Clathrin-Mediated Endocytosis as a Marker of Cell Membrane Tension in Cultured Cells and Developing Organisms." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534434899256265.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Бабич, І., О. В. Калінкевич, Максим Володимирович Погорєлов, Максим Владимирович Погорелов та Maksym Volodymyrovych Pohorielov. "Дослідження біодеградації мембран на основі хітозану". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/31861.

Full text
Abstract:
В останні роки збільшилась кількість досліджень можливості застосування в якості основи для біологічно активних матеріалів хітозана, який є похідним природного полімеру хітину. Даний матеріал володіє цілим рядом властивостей, які обумовлюють його використання для пластики дефектів шкіри – відновлюваність ресурсів, відсутність токсичності, апірогенність, гемостатичні та бактеріостатичні властивості, біосумісність таздатність до біодеградації. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/31861
APA, Harvard, Vancouver, ISO, and other styles
32

Raychaudhuri, Pinky. "Bilayer formation with fluorinated amphiphiles and applications in membrane protein studies." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f8d7ec23-7b2f-4610-b7c8-395b2660464a.

Full text
Abstract:
Every cell is enclosed by a membrane which gives structure to the cell and allows for the passage of nutrients and wastes into and out of the cell. Membranes are made up of amphiphilic lipid molecules, with one water-soluble end, and one hydrophobic end. Naturally occurring and synthetic membranes are made up of double-chained amphiphiles derived from hydrocarbons. Recently, a novel class of amphiphilic molecules derived from fluorocarbons have been reported. The properties of fluorinated amphiphiles are very different to that of hydrocarbon based amphiphiles. Fluorinated amphiphiles have been
APA, Harvard, Vancouver, ISO, and other styles
33

Unnerståle, Sofia. "NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer." Licentiate thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-59534.

Full text
Abstract:
The complexity of multi cellular organisms demands systems that facilitate communicationbetween cells. The neurons in our brains for instance are specialized in this cell-cellcommunication. The flow of ions, through their different ion channels, across the membrane, isresponsible for almost all of the communication between neurons in the brain by changing theneurons membrane potentials. Voltage-gated ion channels open when a certain thresholdpotential is reached. This change in membrane potential is detected by voltage-sensors in the ionchannels. In this licentiate thesis the Homo sapiens volt
APA, Harvard, Vancouver, ISO, and other styles
34

Nevzorov, Alexander 1969. "Dynamical and equilibrium properties of membrane constituents and nucleic acids from deuterium NMR spectroscopy." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282662.

Full text
Abstract:
The chemically non-perturbing deuterium (²H) spin probe provides a unique tool for investigating equilibrium and dynamical properties of lipids, integral membrane proteins, and nucleic acids in relation to their biological activity. Analysis of ²H nuclear magnetic resonance (NMR) relaxation rates gives information about reorientation rates and mean-squared amplitudes; whereas simulation of the spectral lineshapes obtained within the biological temperature range yields bond angles and degree of ordering. In the first part of the dissertation, the frequency dependent ²H NMR spin-lattice relaxati
APA, Harvard, Vancouver, ISO, and other styles
35

Harland, Christopher William 1983. "Desiccation resistance and viscoelasticity in model membrane systems." Thesis, University of Oregon, 2010. http://hdl.handle.net/1794/10993.

Full text
Abstract:
xii, 89 p. : ill. (some col.) A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.<br>Lipid membranes are a basic structural element of all cells. They provide a framework for the physical organization of the cell, act as a scaffold for numerous proteins, and serve as the host site for countless chemical reactions integral to cell function. Several key problems in membrane biophysics hinge on reliable methods for measuring membrane material properties. Properties such as rigidity, fluidity, charge density, etc., are i
APA, Harvard, Vancouver, ISO, and other styles
36

Al-Izzi, Sami. "Dynamics of lipid membrane tubes." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS674.

Full text
Abstract:
Les tubes membranaires sont des structures omniprésentes dans les cellules, et la compréhension de leur dynamique et de leur morphologie est d'une importance cruciale pour la biophysique cellulaire. Cette thèse aborde plusieurs aspects de la dynamique des tubes membranaires dans des situations où ils sont déséquilibrés par divers processus inspirés par des phénomènes biologiques. Nous analysons le gonflement de tubes due à des pompes ioniques entraînant une différence de pression osmotique, ainsi que les instabilités qui en résultent. Ceci est inspiré par la structure d'un organelle appelé le
APA, Harvard, Vancouver, ISO, and other styles
37

CAO, BAOQIANG. "ON APPLICATIONS OF STATISTICAL LEARNING TO BIOPHYSICS." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1168577852.

Full text
APA, Harvard, Vancouver, ISO, and other styles
38

Macchi, Sara. "Peptide-driven cell membrane permeation." Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85923.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Kim, Irene. "Mechanisms of Membrane Disruption by Viral Entry Proteins." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10192.

Full text
Abstract:
To enter and infect cells, viruses must overcome the barrier presented by the cell membrane. Enveloped viruses, which possess their own lipid bilayer, fuse their viral membrane with the cell membrane. Non-enveloped viruses, whose outer surface is composed of proteins, penetrate through the hydrophobic interior of the cell membrane. Viruses accomplish the processes by coupling conformational changes in viral "entry proteins" to membrane disruption. This dissertation investigates the membrane disruption mechanisms of rotavirus, a non-enveloped virus, and vesicular stomatitis virus (VSV), an enve
APA, Harvard, Vancouver, ISO, and other styles
40

Robson, Alex J. "Single particle tracking as a tool to investigate the dynamics of integrated membrane complexes in vivo." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:7769f80c-a56d-4513-9123-1d65ef8c9911.

Full text
Abstract:
The last decade has seen substantial advances in single-molecule tracking methods with nano-metre level precision. A powerful tool in single-molecule tracking is fluorescence imaging. One particular application, total internal reflection microscopy, can capture biological processes at high contrast video rate imaging at the single-particle level. This thesis presents methodologically novel methods in analysing single particle tracking data. Presented here is an application of a Bayesian statistical approach that can discriminate between the different diffusive modes that appear with the presen
APA, Harvard, Vancouver, ISO, and other styles
41

Ho, Joseph Daniel. "Heterologous expression of human membrane protein drug targets and the X-ray crystallographic determination of the human aquaporin 4 structure." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378489.

Full text
APA, Harvard, Vancouver, ISO, and other styles
42

Foroutan, Arash. "Biophysical Studies of the Tachykinin Peptides: Structural Characterization and Membrane Interactions." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/107884.

Full text
Abstract:
En aquesta tesi doctoral, s’han aplicat metodologies biofísiques per estudiar i caracteritzar l'estructura dels pèptids substància P (SP), neuroquinina A (NKA) i scyliorinina I (ScyI), que pertanyen a la família de les taquiquinines (TK), així com la seva manera d'interacció amb membranes model. Els pèptids TKS són agonistes dels receptors de neuroquinina acoblats a la proteïna G. Els TKS estan involucrats en diversos processos fisiològics i malalties com el càncer, malalties neurodegeneratives i respostes inflamatòries, i això els converteix en un objecte de gran interès per a l'estudi estruc
APA, Harvard, Vancouver, ISO, and other styles
43

Nilsson, Martin. "GIANT UNILAMELLAR VESICLES FOR PEPTIDE-MEMBRANE INTERACTION STUDIES USING FLUORESCENCE MICROSCOPY." Thesis, Linköpings universitet, Biofysik och bioteknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167467.

Full text
Abstract:
Vesicles are a type of biological or biomimetic particle consisting of one or more often spherical bilayers made up of amphipathic molecules, creating a closed system. They can function as an encapsulating device, holding hydrophilic molecules on the inside of the bilayer membrane(s) or hydrophobic molecules in the non-polar interstitial space in the middle of the bilayers. Because of this capacity to carry molecules, vesicles are a premier system for drug delivery and even theranostics in vivo. A peptide-based approach to release of encapsulated molecules has previously been developed but sin
APA, Harvard, Vancouver, ISO, and other styles
44

Köcher, Paul Tilman. "Nanoscale measurements of the mechanical properties of lipid bilayers." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:0b478b9f-70fc-436f-9803-5d3a203f0d7e.

Full text
Abstract:
Lipid bilayers form the basis of the membranes that serve as a barrier between a cell and its physiological environment. Their physical properties make them ideally suited for this role: they are extremely soft with respect to bending but essentially incompressible under lateral tension, and they are quite permeable to water but essentially impermeable to ions which allows the rapid establishment of the osmotic gradients. The function of membrane proteins, which are vital for tasks ranging from signal transduction to energy conversion, depends on their interactions with the lipid environment.
APA, Harvard, Vancouver, ISO, and other styles
45

Parton, Daniel L. "Pushing the boundaries : molecular dynamics simulations of complex biological membranes." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:7ab91b51-a5ae-46b4-b6dc-3f0dd3f0b477.

Full text
Abstract:
A range of simulations have been conducted to investigate the behaviour of a diverse set of complex biological membrane systems. The processes of interest have required simulations over extended time and length scales, but without sacrifice of molecular detail. For this reason, the primary technique used has been coarse-grained molecular dynamics (CG MD) simulations, in which small groups of atoms are combined into lower-resolution CG particles. The increased computational efficiency of this technique has allowed simulations with time scales of microseconds, and length scales of hundreds of nm
APA, Harvard, Vancouver, ISO, and other styles
46

Oglęcka, Kamila. "Biophysical studies of membrane interacting peptides derived from viral and Prion proteins." Doctoral thesis, Stockholm University, Department of Biochemistry and Biophysics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7109.

Full text
Abstract:
<p>This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR.</p><p>The peptides derived from the Prion and Doppel proteins combined with their subsequent nuclear localization-like sequences, makes them resemble cell-penetrating peptides (CPPs). mPrPp(1-28), corresponding to the first 28
APA, Harvard, Vancouver, ISO, and other styles
47

Göpfrich, Kerstin. "Rational design of DNA-based lipid membrane pores." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269318.

Full text
Abstract:
DNA nanotechnology has revolutionised our capability to shape and control three-dimensional structures at sub-nanometre length scales. In this thesis, we use DNA to build synthetic membrane-inserting channels. Porphyrin and cholesterol tags serve as membrane anchors to facilitate insertion into the lipid membrane. With atomic force microscopy, confocal imaging and ionic current recordings we characterise our DNA nanochannels that mimic their natural protein-based counterparts in form and function. We find that they exhibit voltage-dependent conductance states. Amongst other architectures, we c
APA, Harvard, Vancouver, ISO, and other styles
48

Stringer, Daniel Kenneth. "The role of ubiquitination within the endocytic pathway." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/2775.

Full text
Abstract:
Ubiquitination is a post-translational modification tht mediates sorting of integral membrane proteins to lysosomes for their degradation. ESCRTs (Endosomal Sorting Complex Required For Transport) bind and sequester ubiquitinated membrane proteins and direct them into multivesicular bodies (MVBs). ESCRTs themselves become covalently ubiquitinated, simply by virtue of non-covalently binding Ub. However, it is unclear whether this regulates a critical aspect of ESCRT function. In yeast, many MVB cargo proteins are ubiquitinated by the HECT-type Ub-ligase Rsp5, sometimes via the action of Rsp5 ad
APA, Harvard, Vancouver, ISO, and other styles
49

Andersson, August. "The Application of isotropic bicelles as model membranes." Doctoral thesis, Stockholm University, Department of Biochemistry and Biophysics, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-497.

Full text
Abstract:
<p>Isotropic bicelles are disc-shaped aggregates of lipids and detergents, and are suitable model systems for high-resolution NMR studies of membrane-interacting peptides. In this thesis the structures for the two peptides motilin and transportan were determined by homonuclear <sup>1</sup>H methods in the presence of bicelles, and the structure of the bovine prion protein peptide (bPrPp) was solved in the presence of DHPC micelles. All of these peptides were found to be largely a-helical when bound to the model membranes. In subsequent experiments both motilin and transportan were shown to res
APA, Harvard, Vancouver, ISO, and other styles
50

Nair, Manoj Sadasivan. "Mechanism of Action of Insecticidal Crystal Toxins from Bacillus thuringiensis: Biophysical and Biochemical Analyses of the Insertion of Cry1A Toxins into Insect Midgut Membranes." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218558470.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the bibliographies on the topic 'Membrane biophysics' for other source types:
Journal articles Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography