Academic literature on the topic 'Membrane destabilization'

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Journal articles on the topic "Membrane destabilization"

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Sun, Jan, Elena E. Pohl, Oxana O. Krylova, et al. "Membrane destabilization by ricin." European Biophysics Journal 33, no. 7 (2004): 572–79. http://dx.doi.org/10.1007/s00249-004-0400-9.

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Storm, G., and E. Wagner. "Membrane destabilization for improved cystolic delivery." Advanced Drug Delivery Reviews 38, no. 3 (1999): 195. http://dx.doi.org/10.1016/s0169-409x(99)00028-9.

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Schutzbach, John S., and John W. Jensen. "Bilayer membrane destabilization induced by dolichylphosphate." Chemistry and Physics of Lipids 51, no. 3-4 (1989): 213–18. http://dx.doi.org/10.1016/0009-3084(89)90008-x.

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Luján, H. D., and D. H. Bronia. "Intermembrane lipid transfer duringTrypanosoma cruzi-induced erythrocyte membrane destabilization." Parasitology 108, no. 3 (1994): 323–34. http://dx.doi.org/10.1017/s0031182000076162.

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SUMMARYThe ability ofTrypanosoma cruzito induce erythrocyte membrane destabilizationin vitrowas studied. Epimastigote forms adhered to human erythrocytes and caused fusion or lysis of the red cells, depending on the conditions of the interaction. Red cells were fused in the presence of calcium, while haemolysis was induced in the absence of the cation. Dextran 60 C facilitated fusion but delayed lysis. Optimum pH and temperature for fusion were 7·4 and 37 °C, respectively. Lipid alterations were produced in the plasma membrane of the red cell during the interaction with the parasite. A Ca2+-in
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Harper, Sandra L., Sira Sriswasdi, Hsin-Yao Tang, Massimiliano Gaetani, Patrick G. Gallagher та David W. Speicher. "The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation". Blood 122, № 17 (2013): 3045–53. http://dx.doi.org/10.1182/blood-2013-02-487702.

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Key Points The common HE mutation αL260P reduces spectrin tetramer links between junctional complexes in red cell membranes by favoring closed dimers. Favoring closed spectrin dimer formation is a new mechanism of red cell membrane destabilization by hereditary anemia mutations.
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Jin, Seok Min, Michael Lazarou, Chunxin Wang, Lesley A. Kane, Derek P. Narendra, and Richard J. Youle. "Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL." Journal of Cell Biology 191, no. 5 (2010): 933–42. http://dx.doi.org/10.1083/jcb.201008084.

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PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson’s disease. It has been found to work in the same pathway as the E3 ligase Parkin in the maintenance of flight muscles and dopaminergic neurons in Drosophila melanogaster and to recruit cytosolic Parkin to mitochondria to mediate mitophagy in mammalian cells. Although PINK1 has a predicted mitochondrial import sequence, its cellular and submitochondrial localization remains unclear in part because it is rapidly degraded. In this study, we report that the mitochondrial inner membrane rhomboid protease presenilin-associat
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Steponkus, Peter. "Membrane destabilization resulting from freeze-induced dehydration." Cryobiology 24, no. 6 (1987): 555. http://dx.doi.org/10.1016/0011-2240(87)90096-4.

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Morales, Joselyn, та Suren A. Tatulian. "Membrane Destabilization by Alzheimer's Amyloid β Peptide". Biophysical Journal 104, № 2 (2013): 239a—240a. http://dx.doi.org/10.1016/j.bpj.2012.11.1351.

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Voisine, Richard, Claude Willemot, and Louis Vézina. "MICROSOMAL MEMBRANE CHANGES IN IRRADIATED CAULIFLOWER DURING STORAGE." HortScience 25, no. 9 (1990): 1086d—1086. http://dx.doi.org/10.21273/hortsci.25.9.1086d.

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Cauliflowers (Brassica oleracea) were irradiated at 0, 2, and 4 kGy and stored 8 days at 13°C. Development of yellow color and browning of the in florescence, increase in membrane electrolyte leakage and reduction of protein recovery in microsomal membranes were observed over the storage period. Changes in membrane free fatty acids, lipid phosphorus content, peroxydation level, and fatty acid composition of polar lipids also occurred. These results indicate an important modification of cellular membranes. The direct effect of gamma rays on membrane lipids via free radical production and subseq
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Lau, Wai Leung, David S. Ege, James D. Lear, Daniel A. Hammer, and William F. DeGrado. "Oligomerization of Fusogenic Peptides Promotes Membrane Fusion by Enhancing Membrane Destabilization." Biophysical Journal 86, no. 1 (2004): 272–84. http://dx.doi.org/10.1016/s0006-3495(04)74103-x.

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Dissertations / Theses on the topic "Membrane destabilization"

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Botes, Jacobus Petrus. "Flux enhancement using flow destabilization in capillary membrane ultrafiltration." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51763.

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Thesis (MEng.)--University of Stellenbosch, 2000.<br>ENGLISH ABSTRACT: The aim of the thesis was to investigate the use of flow destabilization methods, combined with permeate backflushing (BIF) or on their own, on flux recovery and maintenance in capillary UF membrane systems under cross-flow (XF) and dead-end (DE) operating conditions. Various hydraulic and mechanical methods have been used to remove the accumulated cake layer and improve steady state process flux. Permeate backflushing (B/F) is the most widely used but the drawbacks are loss of product and extensive down-time. In a pi
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Flores-Canales, Jose C. "Computational Studies of Acidic Destabilization and Membrane Association of Diphtheria Toxin Translocation (T) Domain." Research Showcase @ CMU, 2014. http://repository.cmu.edu/dissertations/1038.

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Diphtheria toxin translocation (T) domain is a water soluble protein that consists of ten alpha-helices in high pH solution. Experimental studies have determined that T-domain undergoes conformational changes upon decrease of solution pH, which shifts the protein population from its initial water soluble to a membrane-competent in solution. It was hypothesized that conformational changes of the latter state prepare the protein structure for subsequent membrane binding. After binding, refolding of T-domain on the membrane results in the formation of a transmembrane state, which is characterized
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Almeida, João Carlos Ribas de. "Ataxin-3 aggregation and its impact on membrane destabilization." Master's thesis, 2010. http://hdl.handle.net/10316/28723.

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Fani, Giulia. "IDENTIFICATION OF MEMBRANE CA2+ CHANNELS ACTIVATED BY PROTEIN MISFOLDED OLIGOMERS AND THEIR ACTIVATION MECHANISM." Doctoral thesis, 2021. http://hdl.handle.net/2158/1260286.

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Alzheimer’s disease is the most common form of dementia, characterized by the aggregation of the amyloid β peptide (Aβ) in the brain and by an impairment of calcium homeostasis caused by excessive activation of glutamatergic receptors, named excitotoxicity. Here, we studied the effects on calcium homeostasis caused by the formation of Aβ oligomeric assemblies, formed with Aβ40 and Aβ42 peptide, and by the model protein HypF-N. We found that these oligomers cause a rapid influx of calcium ions (Ca2+) across the cell membrane by rapidly activating extrasynaptic N-methyl-D-aspartate receptors (NM
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Book chapters on the topic "Membrane destabilization"

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Steponkus, P. L., and M. S. Webb. "Freeze-Induced Dehydration and Membrane Destabilization in Plants." In Water and Life. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76682-4_20.

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Dunina-Barkovskaya, Antonina. "Cholesterol Recognition Motifs (CRAC) in the S Protein of Coronavirus: A Possible Target for Antiviral Therapy?" In Management of Dyslipidemia. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95977.

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Some interactions of enveloped viruses with the host cell membrane have a cholesterol-dependent component, which may account for clinical manifestations of the infectious disease and can be used for the development of antiviral drugs. These cholesterol-dependent interactions can be mediated by cholesterol-recognition amino-acid consensus (CRAC) motifs present in viral proteins. The S protein of the SARS-CoV and SARS-CoV2 coronaviruses contains CRAC motifs that can be involved in the process of virus entry into the cell. Besides, during viral envelope formation, CRAC motifs can be responsible f
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Díaz, Mario, and Raquel Marin. "Lipid Rafts and Development of Alzheimer’s Disease." In Cerebral and Cerebellar Cortex – Interaction and Dynamics in Health and Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.94608.

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A wealth of evidence accumulated over the last two decades has unambiguously linked lipid rafts to neurodegenerative diseases, in particular to Alzheimer’s disease (AD). These microdomains are highly dynamic membrane platforms with differentiated physicochemical and molecular properties compared to the surrounding membrane microenvironment, and are the locus for a number of central processes in neuronal physiology. Most recent evidence pinpoint to lipid rafts as main players in AD neuropathology. It is now widely accepted that lipid rafts actively participate in the processing of amyloid precu
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Adetunji, Charles Oluwaseun, Olugbemi Tope Olaniyan, Osikemekha Anthony Anani, et al. "Role of biosurfactant in the destruction of pores and destabilization of the biological membrane of pathogenic microorganisms." In Green Sustainable Process for Chemical and Environmental Engineering and Science. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-85146-6.00014-0.

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Ghosh, Sudip Kumar, Priyanka Pal, Sayanta Mondal, et al. "Halotolerant Plant Growth Promoting Rhizobacteria: The Hidden Gem." In Plant-Microbe Interactions: A Comprehensive Review. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815324150125010013.

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Soil salinization results in the continuous reduction of agricultural land worldwide. Salinity, a major abiotic stressor, adversely affects plant growth and development by interfering with various physiological, biochemical, and molecular processes. These processes include nutrient imbalance, osmotic stress, ionic stress, oxidative stress, membrane destabilization, reduced photosynthetic capacity, protein synthesis, energy and lipid metabolism, DNA replication, protein metabolism, and cell division. Despite the rapid increase in the global population, food production is not sufficient to meet
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Steponkus, Peter L., Matsuo Uemura, and Murray S. Webb. "Freeze-Induced Destabilization of Cellular Membranes and Lipid Bilayers." In Permeability and Stability of Lipid Bilayers. CRC Press, 2017. http://dx.doi.org/10.1201/9780203743805-4.

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Joner, Michael, Maria Isabel Castellanos, Anna Bulin, and Kristin Steigerwald. "Pathology of stable coronary artery disease." In ESC CardioMed, edited by William Wijns. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0325.

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Coronary artery disease remains the major cause of morbidity and mortality on a global scale. Intimal thickening and fatty streaks represent early adaptive vascular changes, which are often regressive. Pathological intimal thickening represents the earliest progressive atherosclerotic lesion characterized by a focal accumulation of smooth muscle cells and acellular areas, often associated with lipid pools. Fibroatheroma is characterized by a necrotic core and can be split into early and late fibroatheroma, where macrophage apoptosis and defective efferocytosis play important roles in lesion pr
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Joner, Michael, Maria Isabel Castellanos, Anna Bulin, and Kristin Steigerwald. "Pathology of stable coronary artery disease." In ESC CardioMed, edited by William Wijns. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0325_update_001.

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Coronary artery disease remains the major cause of morbidity and mortality on a global scale. Intimal thickening and fatty streaks represent early adaptive vascular changes, which are often regressive. Pathological intimal thickening represents the earliest progressive atherosclerotic lesion characterized by a focal accumulation of smooth muscle cells and acellular areas, often associated with lipid pools. Fibroatheroma is characterized by a necrotic core and can be split into early and late fibroatheroma, where macrophage apoptosis and defective efferocytosis play important roles in lesion pr
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Conference papers on the topic "Membrane destabilization"

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Zheng, Ying, and Wilson S. Meng. "Polycation Coated Polymeric Particles as Vehicles of RNA Delivery Into Immune Cells." In ASME 2010 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2010. http://dx.doi.org/10.1115/smasis2010-3714.

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The purpose of this work is to develop a carrier system for delivering RNA molecules aimed to downregulate specific functions in T cells. In many forms of cancer, T cells that express the protein Forkhead Box P3 (Foxp3) are associated with cancer progression. These cells can be identified by CD4 and CD25, molecules express on the cell surface. Studies have shown that downregulation of Foxp3 can increase the ability of other immune cells to destroy tumors. A class of RNA molecules, commonly referred to as “siRNA”, bind to and degrade specific messenger RNA (mRNA) in a sequence-dependent manner
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Ramlee, Azierah, Chel-Ken Chiam, and Rosalam Sarbatly. "Asymmetric membranes for destabilization of oil droplets in produced water from alkaline-surfactant-polymer (ASP) flooding." In 8TH INTERNATIONAL CONFERENCE ON NANOSCIENCE AND NANOTECHNOLOGY 2017 (NANO-SciTech 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5034535.

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