Log in

Relevant bibliographies by topics / Membrane lysosomale / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Membrane lysosomale.

Dissertations / Theses on the topic 'Membrane lysosomale'

Author: Grafiati

Published: 1 February 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Membrane lysosomale.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Jamal, Layal. "Structural and functional characterization of the lysosomal amino acid transporter PQLC2." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL129.

Full text

Abstract:

PQLC2, qui signifie protéine conte- nant des répétitions de boucle proline-glutamine 2, appartient à une famille de protéines de transport membranaires caractérisées par une topologie membranaire à sept hélices et deux motifs proline-glutamine. PQLC2 est localisé dans la membrane lysosomale des cellules mammifères, et des études utilisant du PQLC2 recombinant exprimé dans des ovocytes de Xenopus ont démontré que PQLC2 est un uniporteur qui transporte spécifiquement des acides aminés cationiques. Cependant, sa structure atomique en 3D n’a pas encore été déterminée. En plus de son rôle de transp

APA, Harvard, Vancouver, ISO, and other styles

2

SAMARANI, MAURA. "CELL DAMAGE INDUCED BY LYSOSOMAL IMPAIRMENT: STUDY OF THE ROLE OF PLASMA MEMBRANE SPHINGOLIPIDS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/482301.

Full text

Abstract:

Lysosomes are the principal site of the catabolism of sphingolipids, a class of bioactive lipids mainly associated with the external leaflet of cell plasma membrane. Several lines of evidence support a direct correlation between modifications in sphingolipid pattern and the activation of specific signaling pathways, including apoptosis and autophagy. Loss-of-function mutations in genes coding for lysosomal enzymes involved in sphingolipid catabolism result in severe clinical manifestations called sphingolipidoses. These pathologies belong to the group of Lysosomal Storage Diseases and are char

APA, Harvard, Vancouver, ISO, and other styles

3

Schröder, Bernd. "Proteomanalyse der humanen lysosomalen Membran /." Marburg : Görich & Weiershäuser, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016450683&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Johansson, Ann-Charlotte. "Lysosomal membrane permeabilization : a cellular suicide strategy /." Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11614.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Johansson, Ann-Charlotte. "Lysosomal Membrane Permeabilization : A Cellular Suicide Stragegy." Doctoral thesis, Linköpings universitet, Experimentell patologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11614.

Full text

Abstract:

In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved. The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. We identified cathepsin D as an important factor in staurosporine-induced human fibroblast cell death. After release to the cytosol, cathepsin D promoted mitochondrial release of cytochrome c by proteolytic activation of Bid. Cathepsin D-mediated cleavage of Bid generated two fragments with the apparent molec

APA, Harvard, Vancouver, ISO, and other styles

6

Schneede, Alexander [Verfasser]. "Leben ohne LAMPs : die Folgen des Fehlens der lysosomal assoziierten Membran Proteine LAMP-1 und LAMP-2 auf endosomale, lysosomale Prozesse / Alexander Schneede." Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019811161/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Iveson, Graeme Paul. "Passive diffusion across the lysosome membrane." Thesis, Keele University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315231.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Appelqvist, Hanna. "Lysosomal Membrande Stability and Cathepsins in Cell Death." Doctoral thesis, Linköpings universitet, Experimentell patologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85008.

Full text

Abstract:

Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. The aim of this thesis was to investigate the role of lysosomes in cell death signaling. Previous studies have shown that permeabilization of the lysosomal membrane and release of hyd

APA, Harvard, Vancouver, ISO, and other styles

9

Lachuer, Hugo. "Role of membrane tension in the spatial regulation of lysosomal exocytosis." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS026.

Full text

Abstract:

L'exocytose lysosomale est impliquée dans plusieurs processus cellulaires, mais sa régulation spatio-temporelle est encore peu connue. En utilisant la microscopie de fluorescence à réflexion totale (TIRFM) et des outils de statistiques spatiales, nous avons observé que l’exocytose aléatoire n’était pas distribuée aléatoirement sur la face ventrale de la membrane plasmique de cellules RPE1, mais organisée en agglomérats sur plusieurs échelles de tailles. Même si le taux d’exocytose est régulé par le cytosquelette d’actine, des perturbations de l’actine ou des microtubules par des drogues n’altè

APA, Harvard, Vancouver, ISO, and other styles

10

Apfeldorfer, Coralie. "Lysosome biogenesis during osteoclastogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1164801444532-19433.

Full text

Abstract:

Lysosomes are acidic, hydrolase-rich vesicles capable of degrading most biological macromolecules. During the past several decades, much has been learned about different aspects of lysosome biogenesis. The selective phosphorylation of mannose residues on lysosomal enzymes, in conjunction with specific receptors for the mannose-6-phosphate recognition marker, has been found to be largely responsible for the targeting of newly synthesized lysosomal enzymes to lyzosomes. It is known that lysosomes receive input from both the endocytotic and biosynthetic pathways. Nevertheless the exact molecular

APA, Harvard, Vancouver, ISO, and other styles

11

Kaur, Jasber. "Targeting of membrane proteins to lysosome-related organelles." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397316.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Kuwana, Tomomi. "Characterisation of a lysosomal protein that interfrers with membrane fusion assays." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337875.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Cordier, Guillaume. "Unravelling motor protein organization on lysosomal membranes with super-resolution microscopy." Doctoral thesis, Universitat Politècnica de Catalunya, 2018. http://hdl.handle.net/10803/565415.

Full text

Abstract:

This thesis first develops new methods for high-throughput and multi-color super-resolution microscopy (Chapters 2 and 3). Subsequently, I apply these methods to study the organization of motor proteins on the lysosome membrane inside cells with the purpose of determining how intracellular transport can be regulated via motor-protein organization (Chapter 4). Chapter 1 is an Introduction to the state of the art for our knowledge in microtubule-based intracellular transport. Chapter 2 introduces the single molecule localization techniques that improve the spatial resolution of light microscopy.

APA, Harvard, Vancouver, ISO, and other styles

14

Ebrahim, Roshan. "Biogenesis of lysosomes in macrophages : intracellular pathway of lysosomal membrane protein to lysosomes." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3126.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Foster, Willam. "The effects of lysosomal Ca2+ release on membrane depolarisation and synaptic plasticity in hippocampus." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:044cb37b-fdb7-4c19-b6f7-c9e261817751.

Full text

Abstract:

Intracellular Ca<sup>2+</sup> signalling is essential for the control of almost every physiological process, from muscular contraction to synaptic transmission. Intracellular Ca<sup>2+</sup> signals can be generated from both extracellular or intracellular Ca<sup>2+</sup> stores. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous and important Ca<sup>2+</sup> mobilising second messenger. NAADP signalling causes Ca<sup>2+</sup> release from intracellular acidic Ca<sup>2+</sup> stores. The functional roles of NAADP signalling and acidic store Ca<sup>2+</sup> release in the cen

APA, Harvard, Vancouver, ISO, and other styles

16

Crombie, Andrea Rene. "Lysosomal integral membrane protein II, a member of the CD36 gene family : comparative analysis of structure-function relationships /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733079741&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Steenhuis, Pieter [Verfasser], and Stephan [Akademischer Betreuer] Storch. "Intracellular Sorting and Biochemical Analysis of the Lysosomal Membrane Protein CLN7 / Pieter Steenhuis. Betreuer: Stephan Storch." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1069376825/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Danaher, Michelle [Verfasser]. "Characterisation of the Lysosomal Integral Membrane Protein Type 2 (LIMP‐2)in Murine Brain / Michelle Danaher." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1137509708/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Ecard, Jason. "Mécanismes de tri et voies de transport intracellulaire des protéines de la membrane du lysosome." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS094.pdf.

Full text

Abstract:

Plus d’une soixantaine de protéines différentes sont insérées dans la membrane du lysosome et participent aux différentes fonctions de cet organite. Mais les voies de transport intracellulaire qui mènent les protéines membranaires lysosomales (LMP) jusqu’à cet organite ne sont pas bien comprises. De façon intéressante, certaines LMP présentent des localisations intracellulaires anormales dans certains cancers. C’est notamment le cas de la glycoprotéine LAMP1 qui s’avère surexposée à la surface cellulaire dans plusieurs cancers, où elle y joue plusieurs rôles dans l’agressivité tumorale. Grâce

APA, Harvard, Vancouver, ISO, and other styles

20

Stringer, Daniel Kenneth. "The role of ubiquitination within the endocytic pathway." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/2775.

Full text

Abstract:

Ubiquitination is a post-translational modification tht mediates sorting of integral membrane proteins to lysosomes for their degradation. ESCRTs (Endosomal Sorting Complex Required For Transport) bind and sequester ubiquitinated membrane proteins and direct them into multivesicular bodies (MVBs). ESCRTs themselves become covalently ubiquitinated, simply by virtue of non-covalently binding Ub. However, it is unclear whether this regulates a critical aspect of ESCRT function. In yeast, many MVB cargo proteins are ubiquitinated by the HECT-type Ub-ligase Rsp5, sometimes via the action of Rsp5 ad

APA, Harvard, Vancouver, ISO, and other styles

21

Bell, Catherine M. "RHEB DYNAMICS ON LYSOSOMAL MEMBRANES DETERMINES MTORC1 ACTIVITY AFTER LOSS OF P53 OR ACTIVATION OF AMPK." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4036.

Full text

Abstract:

The tumor suppressor TP53 is the most frequently altered gene in human cancers. The growth-promoting complex, mTORC1 plays a part of the oncogenic profile caused by dysfunctional p53. mTORC1 sits downstream of AMPK and other crucial tumor suppressors/oncogenes, PTEN, LKB1, and Akt. The antifolate pemetrexed was found by this laboratory to activate AMPK via the inhibition of the enzyme AICART in de novo purine synthesis. This work presents a mechanism of mTORC1 activation with p53 loss, as well as of mTORC1 inhibition by pemetrexed-induced AMPK. We have found that mTORC1 activity was substantia

APA, Harvard, Vancouver, ISO, and other styles

22

Alvarez, Valadez Karla. "Targeting intracellular cholesterol transport for inducing lysosomal damage and immunogenic cell death in cancer." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL123.

Full text

Abstract:

Les lysosomes jouent un rôle central dans la régulation des processus anaboliques et cataboliques, la signalisation cellulaire ainsi que dans la mise en œuvre des programmes transcriptionnels au sein des cellules. Ils favorisent l’adaptation des cellules cancéreuses lors des variations du microenvironnement en leur fournissant les métabolites essentiels et l’énergie nécessaire à leur survie et à leur prolifération. Un acteur majeur dans la réponse adaptative des lysosomes est le facteur de transcription EB (TFEB). TFEB coordonne l’expression de gènes associés à la fonction et à la biogenèse de

APA, Harvard, Vancouver, ISO, and other styles

23

Kongmanas, Kessiri. "Roles of Seminolipid and Its Associated Membrane Domain in Male Fertility." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32509.

Full text

Abstract:

Our research aims at understanding the roles of seminolipid (sulfogalactosylglycerolipid or SGG) and its associated membrane domains in male reproduction. SGG is a sulfoglycolipid present selectively and abundantly in mammalian male germ cells. Therefore, information on its properties would be relevant towards the development of male fertility biomarkers and spermicide-based contraceptives. We have shown that SGG has direct affinity for zona pellucida (ZP, egg extracellular matrix) and plays a role in the formation of sperm lipid rafts, the ZP-binding platforms on the sperm anterior head pl

APA, Harvard, Vancouver, ISO, and other styles

24

Chandramohanadas, Rajesh. "Rapid purification of human lysosomal membranes, characterisation of the detergent resistant microdomains, purification and reconstitution of the vacuolar proton pump (V-ATPase)." [S.l.] : [s.n.], 2006. http://archiv.ub.uni-marburg.de/diss/z2006/0240.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Pasquier, Adrien. "Lysosomal degradation of insulin granules promotes β-cell failure in type 2 diabetes". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ083/document.

Full text

Abstract:

Notre équipe a récemment découvert l’importance du ciblage des granules d’insuline aux lysosomes lors d’une mise à jeun chez les cellules pancréatiques β. Le diabète de type 2 (TD2) est caractérisé par la résistance à l’insuline couplé au dysfonctionnement des cellules β-et à leur perte. Je souhaitais évaluer le ciblage des granules d’insuline aux lysosomes dans le contexte diabétique. Grâce à un modèle murin, nous avons trouvé que le nombre des lysosomes contenant des granules d’insuline était augmenté chez les cellules β-provenant de souris diabétiques en comparaison aux contrôles. Ceci étai

APA, Harvard, Vancouver, ISO, and other styles

26

Zunke, Friederike [Verfasser]. "Characterisation of the Lysosomal Integral Membrane Protein Type-2 (LIMP-2) and its interaction with b-Glucocerebrosidase: implications for Parkinson and Gaucher Disease / Friederike Zunke." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1172288046/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Cunningham, Dawn Anne. "Human lysosomal associated membrane protein-2 (LAMP-2) : a molecular bridge between infection and autoimmunity in an animal model of focal necrotising and crescentic glomerulonephritis (FNCGN)." Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485684.

Full text

Abstract:

Pauci-immune focal necrotising and crescentic glomerulonephritis (FNCGN) is a severe form of kidney disease often associated with anti-neutrophil cytoplasmic antibodies (ANCA). Well pocumented . ANCA target proteins . include myeloperoxidase (MPO) and proteinase 3 (PR3), both contained in the Iysosomes of neutrophils. A study by Kain et al (1995) identified a novel ANCA target; lysosomal associated membrane protein 2 (LAMP-2) (Kain et aI., 1995) recognised by FNCGN patient sera. An immunodominant epitope shares sequence homology with a peptide found on bacterial adhesion protein fimH (Kain et

APA, Harvard, Vancouver, ISO, and other styles

28

Bodammer, Beatrice [Verfasser], Ralf [Akademischer Betreuer] Ficner, Kurt von [Akademischer Betreuer] Figura, and Hans-Joachim [Akademischer Betreuer] Fritz. "Untersuchung der Acetyl-Coenzym A:alpha-Glucosaminid N-Acetyltransferase in gereinigten lysosomalen Membranen / Beatrice Bodammer. Gutachter: Kurt von Figura ; Hans-Joachim Fritz. Betreuer: Ralf Ficner." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1043029028/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Qu, Yan. "Regulation of Multiple Membrane Trafficking Pathways Stimulated by P2X7 Receptor Activation in Inflammatory Macrophages." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1221066011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Ziegler, Paul K. [Verfasser], Florian R. [Akademischer Betreuer] Greten, Thomas [Gutachter] Kirchner, Thomas [Gutachter] Korn, and Bernhard [Gutachter] Holzmannn. "Stat3 Prevents Mitophagy and Lysosomal Membrane Permeabilization in Intestinal Epithelial Cells to Suppress Adaptive Immunity during Tumorigenesis / Paul K. Ziegler ; Gutachter: Thomas Kirchner, Thomas Korn, Bernhard Holzmannn ; Betreuer: Florian R. Greten." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1181326338/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Strathmann, Marc. "Auswirkungen der Bestrahlung mit UVB, UVA-1 und PUVA-1 auf das Funktionsverhalten humaner dermaler Mastzellen nach Stimulation mit anti-IgE und Substanz P." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972615822.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Atakpa, Peace. "Ca2+ signalling between the endoplasmic reticulum and lysosomes." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288002.

Full text

Abstract:

Ca2+ is a universal and versatile intracellular messenger, regulating a vast array of biological processes due to variations in the frequency, amplitude, spatial and temporal dynamics of Ca2+ signals. Increases in cytosolic free Ca2+ concentration ([Ca2+]c) are due to influx from either an infinite extracellular Ca2+ pool or from the more limited intracellular Ca2+ stores. Stimulation of the endogenous muscarinic (M3) receptors of human embryonic kidney (HEK) cells with carbachol results in the activation of phospholipase C (PLC) and formation of inositol 1,4,5-trisphosphate (IP3), activation

APA, Harvard, Vancouver, ISO, and other styles

33

Wenham, Matt. "The role of Adaptor Protein 3 in cytotoxic T lymphocytes." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:1a5c1fd6-c8cc-454f-81a5-b9a5a18c1540.

Full text

Abstract:

Cytotoxic T lymphocytes (CTL) kill virally infected and tumourigenic cells via the regulated secretion of specialised secretory lysosomes. These secretory lysosomes contain cytolytic effector molecules, such as perforin and granzymes, which are able to induce apoptosis in target cells. Secretion occurs at the contact point between the CTL and its target, in a highly structured region termed the immunological synapse (IS). Upon formation of the IS, CTL undergo polarisation of their microtubule cytoskeleton and movement of the microtubule organising centre (MTOC) to the IS. Secretory lysosomes a

APA, Harvard, Vancouver, ISO, and other styles

34

Tejle, Katarina. "Leishmania donovani Lipophosphoglycan : Modulation of Macrophage and Dendritic Cell Function." Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6527.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Rizzato, Vanessa Rodrigues. "Envolvimento da neuraminidase-1 na atrofia muscular." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-01122014-094857/.

Full text

Abstract:

Sialidose é uma doença neurossomática causada pela deficiência congênita da neuraminidase-1 (Neu1), enzima envolvida na regulação do catabolismo de sialoglicoconjugados nos lisossomos. Com o acúmulo de sialoglicoconjugados, ocorre comprometimento sistêmico e neurológico. Achados histológicos musculares incluem expansão da matriz extracelular (MEC) devido à proliferação anormal de fibroblastos, invasão das fibras musculares por componentes da MEC, fragmentação do citoplasma, formação vacuolar e atrofia das fibras musculares. Entretanto o mecanismo da atrofia muscular na deficiência de Neu1 não

APA, Harvard, Vancouver, ISO, and other styles

36

Lang, Thierry. "Etude des interactions macrophage-bacterie : cinetique des communications entre le phagosome contenant des bacteries pathogenes ou non pathogenes et les autres compartiments membranaires impliques dans l'endocytose." Paris 7, 1987. http://www.theses.fr/1987PA077126.

Full text

Abstract:

Determiner si la pathogenicite de microbacterium avium s'exprime par une alteration du processus d'endocytose chez le macrophage de la moelle osseuse de souris. Caracterisation des echanges membranaires entre la surface cellulaire et les differents compartiments vacuolaires (pinosomes, endosomes, lysosomes) au cours de la pinocytose chez des macrophages non infectes ou infectes par une bacterie non pathogene (bacillus subtilis) ou pathogene (m. Avium)

APA, Harvard, Vancouver, ISO, and other styles

37

ALFRED, VICTOR IFEOLUWA. "GENETIC SCREENING TO IDENTIFY INTERACTORS OF ESCRT-II SUBUNIT, VPS25, AND PRELIMINARY CHARACTERISATION OF CANDIDATES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/560382.

Full text

Abstract:

ESCRT (Endosomal Sorting Complex Required for Transport) proteins regulate cell surface receptor degradation by sorting and packaging ubiquitinated cargoes into the intraluminal vesicles of multivesicular bodies (MVBs). A range of human diseases including cancer, and neurodegeneration display altered expression or are caused by mutations of ESCRT subunits. Studies have shown that Drosophila tissues lacking ESCRTs display neoplastic-like features like overproliferation and polarity defects, partly due to aberrant signalling including Notch signalling. To understand ESCRT-regulated processes in

APA, Harvard, Vancouver, ISO, and other styles

38

Parent, Nicolas. "Mécanismes d'activation de la voie lysosomale durant l'apoptose chimio-induite." Thèse, 2009. http://hdl.handle.net/1866/4146.

Full text

Abstract:

L’apoptose est une forme de mort cellulaire essentielle au développement et au maintien de l’homéostase chez les animaux multicellulaires. La machinerie apoptotiq ue requiert la participation des caspases, des protéases conservées dans l’évolution et celle des organelles cytoplasmiques. Les lysosomes subissent des ruptures partielles, labilisation de la membrane lysosomale (LML), qui entraînent l’activation des cathepsines dans le cytoplasme de cellules cancéreuses humaines en apoptose induite par la camptothecin (CPT), incluant les histiocytes humains U-937. Ces modifications lysosomales se m

APA, Harvard, Vancouver, ISO, and other styles

39

Schieweck, Oliver. "Proteomanalyse lysosomaler Membranen: Identifizierung und Charakterisierung neuer lysosomaler Membranproteine." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-B66F-D.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Schieweck, Oliver [Verfasser]. "Proteomanalyse lysosomaler Membranen : Identifizierung und Charakterisierung neuer lysosomaler Membranproteine / vorgelegt von Oliver Schieweck." 2008. http://d-nb.info/995573980/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Hung, Cheng-Yen, and 洪承延. "Purification and Characterization of Porcine Liver Lysosomal Membrane Sialidase." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/50787697478939002358.

Full text

Abstract:

碩士<br>國立陽明大學<br>生物化學研究所<br>88<br>Sialidase (nanH) is a group of glycohydrolytic enzyme, widely distributed in nature, that cleaves sialic acid residues from the oligosaccharide components of glycoconjugates. In this study, the porcine liver sialidase was purified by Fractogel TSK CM650 gel, DEAE Sephacel, p-aminophenyloxamic acid agarose, and heparin agarose chromatographies. We obtained two sialidase preparations, SIAⅠand SIAⅡ, which showed the molecular weight of 55 kDa and 49 kDa, respectively, on the SDS-polyacrylamide gel electrophoresis. By Western blotting, using antibody against the SI

APA, Harvard, Vancouver, ISO, and other styles

42

Richtrová, Eva. "Charakterizace promotorových oblastí genů HGSNAT a GBA, a příspěvek ke studiu patogeneze MPS IIIC a Gaucherovy choroby." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-332280.

Full text

Abstract:

Pathogenesis of mucopolysaccharidosis type IIIC (MPS IIIC) and Gaucher disease has not been yet fully clarified, and the causes of phenotypical variability between the patients with the same genotype in Gaucher disease remain obscure. Because the variants in the regulatory regions of genes can cause phenotypical differences mentioned above, I have studied promoter regions of HGSNAT and GBA genes mutated in these lysosomal disorders. I have shown that there is an alternative promoter of GBA (P2). Additional studies were aimed to elucidate possible physiological functions of P2, and its possible

APA, Harvard, Vancouver, ISO, and other styles

43

"Membrane anchor for vacuolar targeting: expression of a human lysosomal enzyme iduronidase (hIDUA) in transgenic tobacco plants." 2005. http://library.cuhk.edu.hk/record=b5896394.

Full text

Abstract:

Seto Tai Chi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 122-138).<br>Abstracts in English and Chinese.<br>Thesis Committee --- p.ii<br>Statement --- p.iii<br>Acknowledgements --- p.iv<br>Abstract (in English) --- p.v<br>Abstract (in Chinese) --- p.vii<br>Table of Contents --- p.ix<br>List of Tables --- p.xvi<br>List of Figures --- p.xv<br>Chapter Chapter 1 --- General Introduction and Literature Review --- p.1<br>Chapter 1.1 --- Introduction --- p.2<br>Chapter 1.2 --- Tobacco seed as bioreactor --- p.4<br>Chapter 1.2.1

APA, Harvard, Vancouver, ISO, and other styles

44

Cristóvão, Beatriz Isabel Pelicano. "Lysosomal function during candida infection: connexin 43 as a new player in the infection process." Master's thesis, 2021. http://hdl.handle.net/10316/98780.

Full text

Abstract:

Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>Invasive Candidiasis (IC), a life-threatening fungal infection, can be caused by several Candida spp., being Candida albicans the most prevalent specie worldwide. C. albicans is a constituent of the microbiome in most healthy individuals. However, upon perturbations of host immunity, this fungus transits to an opportunistic pathogen. Macrophages are part of the first line of defense against infections as they can engulf and eliminate C. albicans through phagocytosis. After C. albicans engulfment, the yeast

APA, Harvard, Vancouver, ISO, and other styles

45

Chang, Melissa Han Yin 1977. "Characterisation and functional studies of the Lysosome-associated membrane protein (LAMP-1) in circulation / by Melissa Chang Han Yin." Thesis, 2003. http://hdl.handle.net/2440/21961.

Full text

Abstract:

"February, 2003"<br>Addendum inside front cover.<br>Bibliograpy: leaves 200-219.<br>xiv, 219, xiv leaves : ill. (some col.), plates (some col.) ; 30 cm.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2003

APA, Harvard, Vancouver, ISO, and other styles

46

Chang, Melissa Han Yin 1977. "Characterisation and functional studies of the Lysosome-associated membrane protein (LAMP-1) in circulation / by Melissa Chang Han Yin." 2003. http://hdl.handle.net/2440/21961.

Full text

Abstract:

"February, 2003"<br>Addendum inside front cover.<br>Bibliograpy: leaves 200-219.<br>xiv, 219, xiv leaves : ill. (some col.), plates (some col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2003

APA, Harvard, Vancouver, ISO, and other styles

47

Bodammer, Beatrice. "Untersuchung der Acetyl-Coenzym A:alpha-Glucosaminid N-Acetyltransferase in gereinigten lysosomalen Membranen." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-EF66-A.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

ZHANG, HUI-ZHEN, and 張慧珍. "Localization of porcine spleen acid deoxyribonuclease in lysosmes and reassociation of the enzyme with the lysosomal membrane." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/80550301321790072392.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Huynh, Kassidy. "Phagosome Maturation: Aging with pH, Lysosome-associated membrane proteins, and Cholesterol; while staying young with Burkholderia cenocepacia." Thesis, 2009. http://hdl.handle.net/1807/19278.

Full text

Abstract:

Phagocytosis is an innate immune response that is paramount in the clearance of pathogenic particles. Recognition of target particles by phagocytic receptors expressed on phagocytes induces modifications in the underlying actin cytoskeleton to form pseudopods that encircle and internalize the target particle into a membrane bound organelle called the phagosome. The nascent phagosome undergoes a maturation sequence that is characterized by substantial remodeling of the membrane and its luminal contents through interactions with components of the endocytic pathway, culminating in an acidic and h

APA, Harvard, Vancouver, ISO, and other styles

50

Savalas, Lalu Rudyat Telly [Verfasser]. "Biochemical characterization of a novel lysosomal membrane protein disrupted in renal carcinoma 2 (DIRC2) / submitted by Lalu Rudyat Telly Savalas." 2011. http://d-nb.info/1012739732/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!