Relevant bibliographies by topics / Membrane microbubbles

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Academic literature on the topic 'Membrane microbubbles'

Author: Grafiati
Published: 24 April 2022
Last updated: 30 July 2025

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Journal articles on the topic "Membrane microbubbles"

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Beekers, Ines, Simone A. G. Langeveld, Bram Meijlink, et al. "Microbubble-endothelial cell interactions in 3D: Internalization of microbubbles and pore or tunnel formation for drug delivery." Journal of the Acoustical Society of America 151, no. 4 (2022): A174. http://dx.doi.org/10.1121/10.0011015.

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Ultrasound-activated microbubbles can locally enhance vascular drug delivery, but fully understanding the mechanism requires further investigation. The aims of this in vitro study were to (1) assess the initial single microbubble-endothelial cell (n = 301) 3D morphology, (2) determine whether the ligand type on the targeted microbubble affected this morphology, and (3) investigate the morphology’s influence on microbubble oscillation and drug delivery outcome, all using high-resolution 3D confocal microscopy in combination with ultra-high-speed imaging (∼17 Mfps). Non-targeted and IgG1-κ contr
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Li, Yue, Zhiyi Chen, and Shuping Ge. "Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation." BIO Integration 2, no. 1 (2021): 29–36. http://dx.doi.org/10.15212/bioi-2020-0028.

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Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and destruction of microbubbles. Multiple mechanisms are involved in the occurrence of sonoporation, including ultrasonic parameters, microbubbles size, and the distance of microbubbles to cells. Recent advances are beginning to extend applications through the assistance of contrast agents, which allow ultrasound to connect directly to cellular functions suc
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Brans, Veerle A., Michael Gray, Erdinc Sezgin, and Eleanor P. Stride. "Exploration of ultrasound-mediated microbubble-cell membrane interactions using novel protein-loaded microbubbles and their role in immunomodulation." Journal of the Acoustical Society of America 151, no. 4 (2022): A154. http://dx.doi.org/10.1121/10.0010951.

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The immune response is governed by the dynamic spatiotemporal regulation of signalling proteins at the interface between immune cells and their targets. The broadened knowledge of immunology and antitumour immune responses has led to the development of a novel cancer therapy avenue: immunotherapy. Elucidating the underlying mechanisms of immunotherapy is, however, crucial as in some patients, and it is accompanied by a characteristic toxicity profile and severe side effects such as autoimmune endocrinopathies. This requires quantitative investigation of cell-cell interactions, including the ce
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Ternifi, Redouane, Alexis Vivien, Anne Lassus, et al. "Super-resolution ultrasound imaging with monodisperse microbubbles in a chicken embryo model." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A23. http://dx.doi.org/10.1121/10.0026655.

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ULM is a super-resolution imaging method that has transformed ultrasound imaging by beating the diffraction limit, enabling the visualization of blood vessel down to the capillary size. The development of innovative ultrasound responsive agents may allow to further improve the performance of this technology. Bracco is engaged in the formulation and the evaluation of various ultrasound responsive agents for ULM including monodisperse microbubbles. Our recent studies have shown that monodisperse microbubbles increase imaging sensitivity by an order of magnitude in comparison to polydisperse micr
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Leow, Ruen Shan, Jennifer M. F. Wan, and Alfred C. H. Yu. "Membrane blebbing as a recovery manoeuvre in site-specific sonoporation mediated by targeted microbubbles." Journal of The Royal Society Interface 12, no. 105 (2015): 20150029. http://dx.doi.org/10.1098/rsif.2015.0029.

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Site-specific perforation of the plasma membrane can be achieved through ultrasound-triggered cavitation of a single microbubble positioned adjacent to the cell. However, for this perforation approach (sonoporation), the recovery manoeuvres invoked by the cell are unknown. Here, we report new findings on how membrane blebbing can be a recovery manoeuvre that may take place in sonoporation episodes whose pores are of micrometres in diameter. Each sonoporation site was created using a protocol involving single-shot ultrasound exposure (frequency: 1 MHz; pulse length: 30 cycles; peak negative pre
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Harun, M. H. C., and William B. Zimmerman. "Membrane defouling using microbubbles generated by fluidic oscillation." Water Supply 19, no. 1 (2018): 97–106. http://dx.doi.org/10.2166/ws.2018.056.

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Abstract Impurities and colloidal substances are two of many fouling conditions that reduce the membrane filtration performance used in wastewater treatment. This study investigates the potential of fluidic-oscillation-generated microbubbles (MBs) to defoul the filtration membrane. Cartridge filters for microfiltration (MF) of 1 μm pore size were fouled using surface seawater collected from the Hull coastal area. The seawater was circulated at 5.8 L/min to actuate colloidal substance deposition on the membrane surface. The recorded feed channel pressure drop (ΔP) across the membrane filters sh
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Sellman, M., T. Ivert, P. Stensved, M. Högberg, and Bkh Semb. "Doppler ultrasound estimation of microbubbles in the arterial line during extracorporeal circulation." Perfusion 5, no. 1 (1990): 23–32. http://dx.doi.org/10.1177/026765919000500104.

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A pulsed Doppler ultrasound system was used to analyse microbubble intensity and size in the arterial line during extracorporeal circulation (ECC). Thirty male patients, younger than 70 (range 28-69) years, underwent isolated coronary artery bypass grafting with either a bubble oxygenator (Shiley S-100) without (group 1, n = 10) or with (group 2, n = 10) a depth adsorption arterial line filter (Swank High Flow 6000); or with a membrane oxygenator (Shiley M-2000) without a filter (group 3, n = 10). Mean ECC and aortic crossclamp times were similar in the three groups. Measurements were performe
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Jang, Yeongseok, Hyojae Kim, Jinmu Jung, and Jonghyun Oh. "Controlled Thin Polydimethylsiloxane Membrane with Small and Large Micropores for Enhanced Attachment and Detachment of the Cell Sheet." Membranes 12, no. 7 (2022): 688. http://dx.doi.org/10.3390/membranes12070688.

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Polydimethylsiloxane (PDMS) membranes can allow the precise control of well-defined micropore generation. A PDMS solution was mixed with a Rushton impeller to generate a large number of microbubbles. The mixed solution was spin-coated on silicon wafer to control the membrane thickness. The microbubbles caused the generation of a large number of small and large micropores in the PDMS membranes with decreased membrane thickness. The morphology of the thinner porous PDMS membrane induced higher values of roughness, Young’s modulus, contact angle, and air permeability. At day 7, the viability of c
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Grimley, Edward C., Jon Roussey, Nadia Petlakh-Co, Casey Wegner, and Brandon McNaughton. "A superior dead cell removal platform using Akadeum’s BACS microbubbles." Journal of Immunology 206, no. 1_Supplement (2021): 26.05. http://dx.doi.org/10.4049/jimmunol.206.supp.26.05.

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Abstract Single cell sequencing (SCS) is one of the most commonly used analytical techniques for cellular characterization and has become a mainstay in immune profiling. As SCS has gained in popularity and improved in sensitivity, it has become apparent that ambient nucleic acids can have a major impact on the quality and reproducibility of obtained SCS results. Since the bulk of ambient nucleic acids in a sample come from dead or dying cells that have lost membrane integrity, one way to dramatically reduce ambient nucleic acids and decrease background noise in SCS is to remove dead cells from
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Zhang, Lei, Junliang Liu, Chun Liu, Jing Zhang, and Jingliang Yang. "Performance of a fixed-bed biofilm reactor with microbubble aeration in aerobic wastewater treatment." Water Science and Technology 74, no. 1 (2016): 138–46. http://dx.doi.org/10.2166/wst.2016.187.

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Microbubble aeration is supposed to be highly efficient for oxygen supply in aerobic wastewater treatment. In the present study, the performance of a fixed-bed biofilm reactor microbubble-aerated using a Shirasu porous glass (SPG) membrane system was investigated when treating synthetic municipal wastewater. The biofilm formation on the carriers was enhanced with microbubble aeration due to the strong adhesion of microbubbles to the solid surface. The dissolved oxygen concentration, the removals of chemical oxygen demand (COD) and nitrogen, and the oxygen utilization efficiency were influenced
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Dissertations / Theses on the topic "Membrane microbubbles"

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Morris, Julia Kathleen. "Mechanical properties of phospholipid coated microbubbles." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9979.

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Phospholipid coated, inert gas filled microbubbles (MBs) are currently in widespread use in medical applications for the enhancement of diagnostic ultrasound images, and they are promising candidates for use in the area of targeted drug/gene delivery and uptake. As phospholipid coated MBs were developed for use with diagnostic ultrasound, their behaviour under acoustic loading is well investigated, however much less is known about their response to direct mechanical loading, which will potentially prove important as the range of uses of MBs expands. This is particularly true of the existing co
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Melich, Romain. "Préparation et caractérisation de microbulles et microgouttelettes par procédés membranaires pour des applications biomédicales ultrasonores." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1353/document.

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Le développement de différentes formes colloïdales pour la thérapie et le diagnostic médical ultrasonore connait un intérêt croissant depuis de nombreuses années. En particulier, les microbulles de perfluorocarbone (PFC) sont des agents de contraste intéressants, car le gaz est un puissant réflecteur des ultrasons. Plus récemment, les gouttelettes de PFC ont été proposées pour de nouvelles applications acoustiques. Suite à une impulsion acoustique, les ultrasons induisent un changement de phase de l’état liquide à l’état gazeux. Ce phénomène est appelé la vaporisation acoustique de gouttelette
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Pereno, Valerio. "Characterisation of microbubble-membrane interactions in ultrasound mediated drug delivery." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:515f2c15-e9d3-46b8-875c-420084fbc9a3.

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Cancer imposes a significant disease burden and constitutes a major societal challenge. Despite being widely used, chemotherapy suffers numerous disadvantages, including off-target drug toxicity, poor tumour penetration, and drug resistance. The use of ultrasound in combination with contrast agents has shown promise in enhancing outcomes in the treatment of cancerous and non-cancerous diseases. However, the underlying biophysical processes that underpin their interactions with tissues remain poorly understood. The aim of the research presented in this thesis is to develop methods to elucidate
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Mohamedi, Graciela. "Engineering the surface properties of microbubbles for biomedical applications." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e68f2010-19b6-45af-b238-da8e2d29b270.

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Surfactant coated microbubbles are widely used as contrast agents (UCA) in medical ultrasound imaging, due to their high echogenicity and non-linear response to acoustic excitation. Controlling the stability of microbubbles in vivo represents a considerable challenge. Understanding the characteristics of the bubble surface and how they change with production method, composition and environment is key to addressing this problem. The aim of this thesis is to investigate viscosity, bubble dissolution, and acoustic response as functions of their composition, manufacturing method and environment. B
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Shih, Cheng-Ping, and 施政坪. "The Study of Ultrasound-aided Microbubbles in Facilitating The Delivery of Drugs to The Inner Ear via The Round Window Membrane." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/22686724771787849944.

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博士<br>國防醫學院<br>醫學科學研究所<br>104<br>The round window membrane (RWM) acts as a barrier between the middle ear and cochlea and can serve as a crucial route for therapeutic medications entering the inner ear via middle ear applications. The approach in local delivery of drugs to inner ear includes intratympanic and intracochlear approach. The intratympanic approach has the advantage of no insult to inner ear structure and function in comparison of the intracochlear approach. Drug delivery via intratympanic approach depends on the permeation of round window membrane. Microbubbles (MBs) ultrasound is
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Karshafian, Raffi. "On the Permeabilisation and Disruption of Cell Membranes by Ultrasound and Microbubbles." Thesis, 2010. http://hdl.handle.net/1807/24354.

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Therapeutic efficacy of drugs depends on their ability to reach the treatment target. Drugs that exert their effect within cells are constrained by an inability to cross the cell membrane. Methods are being developed to overcome this barrier including biochemical and biophysical strategies. The application of ultrasound with microbubbles increases the permeability of cell membranes allowing molecules, which otherwise would be excluded, to enter the intracellular space of cells; a phenomenon known as sonoporation. This thesis describes studies aimed at improving our understanding of the mec
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Book chapters on the topic "Membrane microbubbles"

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Moosavi-Nejad, S., K. Tachibana, H. Akiyama, and S. H. R. Hosseini. "Visualization of Cell Membrane Poration by Microbubble Oscillation." In 29th International Symposium on Shock Waves 2. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16838-8_16.

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"Circular Acoustic Microstreaming Flows due to Pulsating Microbubbles near a Membrane." In Proceedings of the 10th International Symposium on Cavitation (CAV2018). ASME Press, 2018. http://dx.doi.org/10.1115/1.861851_ch49.

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"Collapse and Jet Formation of Ultrasound Contrast Microbubbles near a Membrane for Sonoporation." In Proceedings of the 10th International Symposium on Cavitation (CAV2018). ASME Press, 2018. http://dx.doi.org/10.1115/1.861851_ch50.

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Konofagou, Elisa E. "Blood–Brain Barrier Opening and Drug Delivery Using Focused Ultrasound and Microbubbles." In Neurobiology of Mental Illness, edited by Karl Deisseroth. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199934959.003.0011.

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Current treatments of neurological and neurodegenerative diseases are limited due to the lack of a truly non-invasive, transient, and regionally selective brain drug delivery method. The brain is particularly difficult to deliver drugs to because of the blood-brain barrier (BBB). The impermeability of the BBB is due to the tight junctions connecting adjacent endothelial cells and highly regulatory transport systems of the endothelial cell membranes. The main function of the BBB is ion and volume regulation to ensure conditions necessary for proper synaptic and axonal signaling. However, the sa
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Conference papers on the topic "Membrane microbubbles"

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Dailey, Hannah L., Huseyin C. Yalcin, and Samir N. Ghadiali. "Multi-Scale Models of Epithelial Cell Injury and Detachment During Microbubble Flows." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176497.

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Certain pathological conditions, e.g. pneumonia or acute lung injury, can lead to fluid buildup in the small pulmonary airways. During breathing, micron-sized air bubbles propagate through the fluid-occluded airways and these microbubbles may exert injurious hydrodynamic stresses on the epithelial cells (EC) which line airway walls. Specifically, the pressure and shear stresses generated during microbubble flows may cause plasma membrane rupture [1], cell detachment [2] and an exacerbation of the existing lung injury.
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Thomas, Antony, Paige Baldwin, and Yaling Liu. "Ultrasound Mediated Enhancement of Nanoparticle Uptake in PC-3 Cancer Cells." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93115.

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Ultrasound in the presence of microbubbles brings in transient increase in cell membrane permeability, which allows the entry of foreign molecules into cells. This platform has been applied in in vitro and in vivo gene delivery studies in recent years[1–2]. The frequently used microbubbles are air or inert gas encapsulated in a protein, lipid or polymer which is commonly used as FDA approved contrast agents in diagnostic ultrasound. On exposure to ultrasound the microbubbles lead to formation of small pores on the cell membrane. This work concentrates on application of this platform to enhance
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Dangi, Ajay, Dhananjay Deshmukh, Robin Singh, and Rudra Pratap. "Dynamics of Strongly Coupled Fluid-Filled Micro-Cavities and PMUTs in Integrated Microfluidic Devices." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59910.

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In this work, we present a novel device developed by integration of an array of Piezoelectric Micromachined Ultrasonic Transducers (PMUTs) with a microfluidic chip that can be used for characterizing the acoustical properties of the liquid present in the back-cavity of the PMUT. PMUT membrane operates in flexural mode of vibration and it is directly coupled with the cylindrical back-cavity formed during the release of the PMUT membrane. This leads to very strong structural-acoustic coupling between the PMUT and the liquid present in the its back-cavity. Presence of fluid around the thin PMUT m
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Gnanaskandan, Aswin, Xiaolong Deng, Chao-Tsung Hsiao, and Georges Chahine. "Modeling Microbubble Microvessel Interaction for Sonoporation Application." In ASME 2020 Fluids Engineering Division Summer Meeting collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/fedsm2020-20407.

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Abstract Modeling the dynamics of microbubbles inside confined spaces has many potential applications in biomedicine, sonoporation being one classic example. Sonoporation is the permeabilization of a blood vessel’s endothelial cell membrane by acoustic waves in order to non-invasively deliver large-sized drug molecules into cells for therapeutic applications. By controlled activation of ultrasound contrast agents (UCA) in a microvessel, one can achieve better permeabilization without causing permanent damage associated with high intensity ultrasound. This paper considers numerically, the fluid
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Karshafian, Raffi, Peter D. Bevan, Sanya Samac, and Peter N. Burns. "The Effect of Acoustic Exposure Parameters on Cell Membrane Permeabilisation by Ultrasound and Microbubbles." In 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2007. http://dx.doi.org/10.1063/1.2744320.

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Tarapacki, Christine, Wolfgang M. Kuebler, Arata Tabuchi, and Raffi Karshafian. "Reversible and irreversible vascular bioeffects induced by ultrasound and microbubbles in chorioallantoic membrane model." In PROCEEDINGS FROM THE 14TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. Author(s), 2017. http://dx.doi.org/10.1063/1.4977663.

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Doinikov, Alexander A., Peggy Palanchon, Kadija Kaddur, and Ayache Bouakaz. "Theoretical exploration of shear stress generated by oscillating microbubbles on the cell membrane in the context of sonoporation." In 2009 IEEE International Ultrasonics Symposium. IEEE, 2009. http://dx.doi.org/10.1109/ultsym.2009.5441631.

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Shi, Jianmin, Tao Han, Alfred C. H. Yu, and Peng Qin. "Characterization of Second Membrane Perforation by Ultrasound-driven Single Microbubble." In 2021 IEEE International Ultrasonics Symposium (IUS). IEEE, 2021. http://dx.doi.org/10.1109/ius52206.2021.9593544.

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Leaute, Gael, James McLaughlan, Sevan Harput, David Cowell, and Steven Freear. "Comsol modelling of non-spherical microbubble dynamics near a soft membrane." In 2012 IEEE International Ultrasonics Symposium. IEEE, 2012. http://dx.doi.org/10.1109/ultsym.2012.0571.

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Karshafian, Raffi, and Peter N. Burns. "Ultrasound and microbubble mediated generation of transient pores on cell membranes in vitro." In 2009 IEEE International Ultrasonics Symposium. IEEE, 2009. http://dx.doi.org/10.1109/ultsym.2009.5441643.

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