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Journal articles on the topic 'Membrane microbubbles'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Beekers, Ines, Simone A. G. Langeveld, Bram Meijlink, et al. "Microbubble-endothelial cell interactions in 3D: Internalization of microbubbles and pore or tunnel formation for drug delivery." Journal of the Acoustical Society of America 151, no. 4 (2022): A174. http://dx.doi.org/10.1121/10.0011015.

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Ultrasound-activated microbubbles can locally enhance vascular drug delivery, but fully understanding the mechanism requires further investigation. The aims of this in vitro study were to (1) assess the initial single microbubble-endothelial cell (n = 301) 3D morphology, (2) determine whether the ligand type on the targeted microbubble affected this morphology, and (3) investigate the morphology’s influence on microbubble oscillation and drug delivery outcome, all using high-resolution 3D confocal microscopy in combination with ultra-high-speed imaging (∼17 Mfps). Non-targeted and IgG1-κ contr

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Li, Yue, Zhiyi Chen, and Shuping Ge. "Sonoporation: Underlying Mechanisms and Applications in Cellular Regulation." BIO Integration 2, no. 1 (2021): 29–36. http://dx.doi.org/10.15212/bioi-2020-0028.

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Ultrasound combined with microbubble-mediated sonoporation has been applied to enhance drug or gene intracellular delivery. Sonoporation leads to the formation of openings in the cell membrane, triggered by ultrasound-mediated oscillations and destruction of microbubbles. Multiple mechanisms are involved in the occurrence of sonoporation, including ultrasonic parameters, microbubbles size, and the distance of microbubbles to cells. Recent advances are beginning to extend applications through the assistance of contrast agents, which allow ultrasound to connect directly to cellular functions suc

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Brans, Veerle A., Michael Gray, Erdinc Sezgin, and Eleanor P. Stride. "Exploration of ultrasound-mediated microbubble-cell membrane interactions using novel protein-loaded microbubbles and their role in immunomodulation." Journal of the Acoustical Society of America 151, no. 4 (2022): A154. http://dx.doi.org/10.1121/10.0010951.

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The immune response is governed by the dynamic spatiotemporal regulation of signalling proteins at the interface between immune cells and their targets. The broadened knowledge of immunology and antitumour immune responses has led to the development of a novel cancer therapy avenue: immunotherapy. Elucidating the underlying mechanisms of immunotherapy is, however, crucial as in some patients, and it is accompanied by a characteristic toxicity profile and severe side effects such as autoimmune endocrinopathies. This requires quantitative investigation of cell-cell interactions, including the ce

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Ternifi, Redouane, Alexis Vivien, Anne Lassus, et al. "Super-resolution ultrasound imaging with monodisperse microbubbles in a chicken embryo model." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A23. http://dx.doi.org/10.1121/10.0026655.

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ULM is a super-resolution imaging method that has transformed ultrasound imaging by beating the diffraction limit, enabling the visualization of blood vessel down to the capillary size. The development of innovative ultrasound responsive agents may allow to further improve the performance of this technology. Bracco is engaged in the formulation and the evaluation of various ultrasound responsive agents for ULM including monodisperse microbubbles. Our recent studies have shown that monodisperse microbubbles increase imaging sensitivity by an order of magnitude in comparison to polydisperse micr

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Leow, Ruen Shan, Jennifer M. F. Wan, and Alfred C. H. Yu. "Membrane blebbing as a recovery manoeuvre in site-specific sonoporation mediated by targeted microbubbles." Journal of The Royal Society Interface 12, no. 105 (2015): 20150029. http://dx.doi.org/10.1098/rsif.2015.0029.

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Site-specific perforation of the plasma membrane can be achieved through ultrasound-triggered cavitation of a single microbubble positioned adjacent to the cell. However, for this perforation approach (sonoporation), the recovery manoeuvres invoked by the cell are unknown. Here, we report new findings on how membrane blebbing can be a recovery manoeuvre that may take place in sonoporation episodes whose pores are of micrometres in diameter. Each sonoporation site was created using a protocol involving single-shot ultrasound exposure (frequency: 1 MHz; pulse length: 30 cycles; peak negative pre

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Harun, M. H. C., and William B. Zimmerman. "Membrane defouling using microbubbles generated by fluidic oscillation." Water Supply 19, no. 1 (2018): 97–106. http://dx.doi.org/10.2166/ws.2018.056.

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Abstract Impurities and colloidal substances are two of many fouling conditions that reduce the membrane filtration performance used in wastewater treatment. This study investigates the potential of fluidic-oscillation-generated microbubbles (MBs) to defoul the filtration membrane. Cartridge filters for microfiltration (MF) of 1 μm pore size were fouled using surface seawater collected from the Hull coastal area. The seawater was circulated at 5.8 L/min to actuate colloidal substance deposition on the membrane surface. The recorded feed channel pressure drop (ΔP) across the membrane filters sh

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Sellman, M., T. Ivert, P. Stensved, M. Högberg, and Bkh Semb. "Doppler ultrasound estimation of microbubbles in the arterial line during extracorporeal circulation." Perfusion 5, no. 1 (1990): 23–32. http://dx.doi.org/10.1177/026765919000500104.

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A pulsed Doppler ultrasound system was used to analyse microbubble intensity and size in the arterial line during extracorporeal circulation (ECC). Thirty male patients, younger than 70 (range 28-69) years, underwent isolated coronary artery bypass grafting with either a bubble oxygenator (Shiley S-100) without (group 1, n = 10) or with (group 2, n = 10) a depth adsorption arterial line filter (Swank High Flow 6000); or with a membrane oxygenator (Shiley M-2000) without a filter (group 3, n = 10). Mean ECC and aortic crossclamp times were similar in the three groups. Measurements were performe

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8

Jang, Yeongseok, Hyojae Kim, Jinmu Jung, and Jonghyun Oh. "Controlled Thin Polydimethylsiloxane Membrane with Small and Large Micropores for Enhanced Attachment and Detachment of the Cell Sheet." Membranes 12, no. 7 (2022): 688. http://dx.doi.org/10.3390/membranes12070688.

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Polydimethylsiloxane (PDMS) membranes can allow the precise control of well-defined micropore generation. A PDMS solution was mixed with a Rushton impeller to generate a large number of microbubbles. The mixed solution was spin-coated on silicon wafer to control the membrane thickness. The microbubbles caused the generation of a large number of small and large micropores in the PDMS membranes with decreased membrane thickness. The morphology of the thinner porous PDMS membrane induced higher values of roughness, Young’s modulus, contact angle, and air permeability. At day 7, the viability of c

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9

Grimley, Edward C., Jon Roussey, Nadia Petlakh-Co, Casey Wegner, and Brandon McNaughton. "A superior dead cell removal platform using Akadeum’s BACS microbubbles." Journal of Immunology 206, no. 1_Supplement (2021): 26.05. http://dx.doi.org/10.4049/jimmunol.206.supp.26.05.

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Abstract Single cell sequencing (SCS) is one of the most commonly used analytical techniques for cellular characterization and has become a mainstay in immune profiling. As SCS has gained in popularity and improved in sensitivity, it has become apparent that ambient nucleic acids can have a major impact on the quality and reproducibility of obtained SCS results. Since the bulk of ambient nucleic acids in a sample come from dead or dying cells that have lost membrane integrity, one way to dramatically reduce ambient nucleic acids and decrease background noise in SCS is to remove dead cells from

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10

Zhang, Lei, Junliang Liu, Chun Liu, Jing Zhang, and Jingliang Yang. "Performance of a fixed-bed biofilm reactor with microbubble aeration in aerobic wastewater treatment." Water Science and Technology 74, no. 1 (2016): 138–46. http://dx.doi.org/10.2166/wst.2016.187.

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Microbubble aeration is supposed to be highly efficient for oxygen supply in aerobic wastewater treatment. In the present study, the performance of a fixed-bed biofilm reactor microbubble-aerated using a Shirasu porous glass (SPG) membrane system was investigated when treating synthetic municipal wastewater. The biofilm formation on the carriers was enhanced with microbubble aeration due to the strong adhesion of microbubbles to the solid surface. The dissolved oxygen concentration, the removals of chemical oxygen demand (COD) and nitrogen, and the oxygen utilization efficiency were influenced

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Juffermans, L. J. M., P. A. Dijkmans, R. J. P. Musters, C. A. Visser, and O. Kamp. "Transient permeabilization of cell membranes by ultrasound-exposed microbubbles is related to formation of hydrogen peroxide." American Journal of Physiology-Heart and Circulatory Physiology 291, no. 4 (2006): H1595—H1601. http://dx.doi.org/10.1152/ajpheart.01120.2005.

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In the present study, we addressed the interactions among ultrasound, microbubbles, and living cells as well as consequent arising bioeffects. We specifically investigated whether hydrogen peroxide (H2O2) is involved in transient permeabilization of cell membranes in vitro after ultrasound exposure at low diagnostic power, in the presence of stable oscillating microbubbles, by measuring the generation of H2O2 and Ca2+ influx. Ultrasound, in the absence or presence of SonoVue microbubbles, was applied to H9c2 cells at 1.8 MHz with a mechanical index (MI) of 0.1 or 0.5 during 10 s. This was repe

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Wang, Yuchen, Hongchen Li, Bram Meijlink, et al. "Monodisperse microbubble-mediated drug delivery: Influence of microbubbles size on drug delivery outcome." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A325. http://dx.doi.org/10.1121/10.0027679.

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As the microbubble's resonance frequency is size-dependent, polydisperse microbubbles induce varying drug delivery outcomes at one ultrasound frequency. This study aimed to investigate drug delivery outcome of monodisperse MBs (mMBs) with radii ranging from 1.5–2.9 μm insonified at 2 MHz. Phospholipid-coated mMBs were generated using the Horizon microfluidic flow-focusing device. In vitro experiments were conducted on single microbubble-endothelial cells (n = 68) using confocal microscopy and 10 Mfps ultra-high-speed imaging. At 220 kPa PNP for 10 cycles, the 1.5 μm mMBs exhibited the highest

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Vlatakis, Stavros, Weiqi Zhang, Sarah Thomas, et al. "Effect of Phase-Change Nanodroplets and Ultrasound on Blood–Brain Barrier Permeability In Vitro." Pharmaceutics 16, no. 1 (2023): 51. http://dx.doi.org/10.3390/pharmaceutics16010051.

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Phase-change nanodroplets (PCND;NDs) are emulsions with a perfluorocarbon (PFC) core that undergo acoustic vaporisation as a response to ultrasound (US). Nanodroplets change to microbubbles and cavitate while under the effect of US. This cavitation can apply forces on cell connections in biological barrier membranes, such as the blood–brain barrier (BBB), and trigger a transient and reversible increased permeability to molecules and matter. This study aims to present the preparation of lipid-based NDs and investigate their effects on the brain endothelial cell barrier in vitro. The NDs were pr

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14

Weitkemper, Heinz-H., Bernd Oppermann, Andreas Spilker, Hermann-J. Knobl, and Reiner Körfer. "Gaseous Microemboli and the Influence of Microporous Membrane Oxygenators." Journal of ExtraCorporeal Technology 37, no. 3 (2005): 256–64. http://dx.doi.org/10.1051/ject/200537256.

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Gaseous microemboli (GME) are still an unsolved problem of extracorporeal circuits. They are associated with organ injury during cardiopulmonary bypass. Microbubbles of different sizes and number are generated in the blood as the result of different components of the extracorporeal circuit as well as surgical maneuvers. The aim of our study was to observe the behavior of microporous membrane oxygenators to GME in the daily use and in an in vitro model. For the detection of microbubbles, we used a two-channel ultrasonic bubble counter based on 2-MHz Doppler-System with special ultrasound probes

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15

Liu, Xiufang, Wenjun Zhang, Yanshu Jing, et al. "Non-Cavitation Targeted Microbubble-Mediated Single-Cell Sonoporation." Micromachines 13, no. 1 (2022): 113. http://dx.doi.org/10.3390/mi13010113.

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Sonoporation employs ultrasound accompanied by microbubble (MB) cavitation to induce the reversible disruption of cell membranes and has been exploited as a promising intracellular macromolecular delivery strategy. Due to the damage to cells resulting from strong cavitation, it is difficult to balance efficient delivery and high survival rates. In this paper, a traveling surface acoustic wave (TSAW) device, consisting of a TSAW chip and a polydimethylsiloxane (PDMS) channel, was designed to explore single-cell sonoporation using targeted microbubbles (TMBs) in a non-cavitation regime. A TSAW w

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16

Ilovitsh, Tali, Yi Feng, Josquin Foiret, et al. "Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites." Proceedings of the National Academy of Sciences 117, no. 23 (2020): 12674–85. http://dx.doi.org/10.1073/pnas.1914906117.

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Robust cytotoxic T cell infiltration has proven to be difficult to achieve in solid tumors. We set out to develop a flexible protocol to efficiently transfect tumor and stromal cells to produce immune-activating cytokines, and thus enhance T cell infiltration while debulking tumor mass. By combining ultrasound with tumor-targeted microbubbles, membrane pores are created and facilitate a controllable and local transfection. Here, we applied a substantially lower transmission frequency (250 kHz) than applied previously. The resulting microbubble oscillation was significantly enhanced, reaching a

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Yang, Shao-ling, Ke-qiang Tang, Wen-kun Bai, et al. "Effects of low-frequency ultrasound combined with microbubbles on benign prostate hyperplasia." Canadian Urological Association Journal 7, no. 11-12 (2013): 681. http://dx.doi.org/10.5489/cuaj.354.

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Introduction: Our objective is to assess the effects of low-frequency ultrasound combined with microbubbles on benign prostate hyperplasia (BPH).Methods: Sixteen Beagle dogs with BPH were randomly assigned into 4 groups (n = 4): control group (without treatment), G1 group (injection with 2 mL of microbubble contrast agent); G2 group (21 kHz ultrasound); and G3 group (injection with 2 mL of microbubble contrast agent +21 kHz ultrasound). The histopathological damage to prostate cells was assessed via transmission electronmicroscopy and optical microscopy. The protein expressions of prostate-spe

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18

Memari, Elahe, Fiona Hui, and Brandon Helfield. "Ultrasound-assisted membrane permeabilization of endothelial cells under flow conditions." Journal of the Acoustical Society of America 151, no. 4 (2022): A173—A174. http://dx.doi.org/10.1121/10.0011014.

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Ultrasound-stimulated microbubbles have been shown a feasible approach for localized therapeutic delivery. As applications of this technique span many anatomical sites, so too do the local fluid dynamics experienced by the circulating microbubbles and the adjacent endothelial cells. Our objective was to assess the relative effectiveness of endothelial cell sonoporation as a function of flow conditions. Human umbilical vein (HUVECs) or human brain endothelial cells (HBECs) were cultured as a monolayer in flow chamber slides connected to a fluidic system and placedupon an acoustically-coupled mi

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Lattwein, Kirby R., Inés Beekers, Joop J. P. Kouijzer, et al. "Dispersing and Sonoporating Biofilm-Associated Bacteria with Sonobactericide." Pharmaceutics 14, no. 6 (2022): 1164. http://dx.doi.org/10.3390/pharmaceutics14061164.

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Bacteria encased in a biofilm poses significant challenges to successful treatment, since both the immune system and antibiotics are ineffective. Sonobactericide, which uses ultrasound and microbubbles, is a potential new strategy for increasing antimicrobial effectiveness or directly killing bacteria. Several studies suggest that sonobactericide can lead to bacterial dispersion or sonoporation (i.e., cell membrane permeabilization); however, real-time observations distinguishing individual bacteria during and directly after insonification are missing. Therefore, in this study, we investigated

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Truong An Tran, J. Y. Le Guennec, P. Bougnoux, F. Tranquart, and A. Bouakaz. "Characterization of cell membrane response to ultrasound activated microbubbles." IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 55, no. 1 (2008): 43–49. http://dx.doi.org/10.1109/tuffc.2008.615.

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Zhang, Jie, Limei Song, Shujing Zhou, et al. "Enhanced ultrasound imaging and anti-tumor in vivo properties of Span–polyethylene glycol with folic acid–carbon nanotube–paclitaxel multifunctional microbubbles." RSC Advances 9, no. 61 (2019): 35345–55. http://dx.doi.org/10.1039/c9ra06437k.

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With Span and polyethylene glycol (PEG) as the membrane material, the as-prepared folate–carbon nanotube–paclitaxel (FA–CNT–PTX) complex was added to the reaction system under sound vibration cavitation and Span–PEG with FA–CNT–PTX microbubbles was obtained.

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Song, Hyeong-Woo, Han-Sol Lee, Seok-Jae Kim, et al. "Sonazoid-Conjugated Natural Killer Cells for Tumor Therapy and Real-Time Visualization by Ultrasound Imaging." Pharmaceutics 13, no. 10 (2021): 1689. http://dx.doi.org/10.3390/pharmaceutics13101689.

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Various cell therapy strategies, including chimeric antigen receptor-expressing T or natural killer (NK) cells and cell-mediated drug delivery, have been developed for tumor eradication. However, the efficiency of these strategies against solid tumors remains unclear. We hypothesized that real-time control and visualization of therapeutic cells, such as NK cells, would improve their therapeutic efficacy against solid tumors. In this study, we engineered Sonazoid microbubble-conjugated NK (NK_Sona) cells and demonstrated that they were detectable by ultrasound imaging in real-time and maintaine

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Jirschik, Mario, Cornelius Keyl, and Friedhelm Beyersdorf. "A clinical comparison of bubble elimination in Quadrox and Polystan oxygenators." Perfusion 24, no. 6 (2009): 423–27. http://dx.doi.org/10.1177/0267659109358206.

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Background: Microbubbles generated during heart surgery on extracorporeal circulation have been implicated as a possible cause of postoperative neurocognitive dysfunction and negative outcome. The main sources of microbubbles in the extracorporeal circuit are air leaking from the venous cannulation site, air delivered by drug and volume administration, during the taking of blood samples, during hemofiltration, and by using vacuum-assisted venous drainage (VAVD). Membrane oxygenators, although not designed for the elimination of gaseous microbubbles, can eliminate much of this air. Aim of the s

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Watabe, Tomoichi, Kazufumi Matsuyama, Tomoki Takahashi, and Hideto Matsuyama. "Use of microbubbles to reduce membrane fouling during water filtration." Desalination and Water Treatment 57, no. 9 (2014): 3820–26. http://dx.doi.org/10.1080/19443994.2014.991946.

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Ali, Mohamed E. A., Rayan Alghanayem, Aislinn Varela, Marion Bellier, and François Perreault. "Scaling mitigation in direct contact membrane distillation using air microbubbles." Desalination 549 (March 2023): 116348. http://dx.doi.org/10.1016/j.desal.2022.116348.

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Colbourne, James R. M., Khaled H. Altoukhi, and David L. Morris. "Peritoneal Oxygenation as a Novel Technique for Extrapulmonary Ventilation; A Review and Discussion of the Literature." Advances in Respiratory Medicine 90, no. 6 (2022): 511–17. http://dx.doi.org/10.3390/arm90060057.

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The COVID-19 crisis has highlighted the difficulties that might occur when attempting to oxygenate patients who have suffered a severe pulmonary insult, including in the development of acute respiratory distress syndrome (ARDS). Traditional mechanical ventilation (MV) is effective; however, in severe cases of hypoxia, the use of rescue therapy, such as extracorporeal membrane oxygenation (ECMO), may be required but is also associated with significant complexity and complications. In this review, we describe peritoneal oxygenation; a method of oxygenation that exploits the peritoneum’s gas exch

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Conway, Grace E., Anurag N. Paranjape, Xucai Chen, and Flordeliza S. Villanueva. "Understanding the mechanisms of ultrasound-targeted microbubble cavitation-mediated blood brain barrier opening." Journal of the Acoustical Society of America 153, no. 3_supplement (2023): A99. http://dx.doi.org/10.1121/10.0018297.

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Ultrasound-targeted microbubble cavitation (UTMC) transiently opens the blood brain barrier (BBB). We previously determined that UTMC induces BBB hyperpermeability through an influx of calcium. As activation of RhoA is a calcium-dependent pathway that causes cytoskeletal reorganization, leading to the breakdown of tight junctions, we tested the hypothesis that UTMC-induced activation of RhoA leads to BBB hyperpermeability. We utilized a transwell model with brain endothelial cells and astrocytes on opposite sides of a support membrane. Ultrasound (1 MHz, 250 kPa, 10 μs pulse duration, 10 ms pu

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Haugse, Ragnhild, Anika Langer, Stein-Erik Gullaksen, et al. "Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells." Pharmaceutics 11, no. 7 (2019): 319. http://dx.doi.org/10.3390/pharmaceutics11070319.

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Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption that pore formation in the cell membrane is responsible for increased uptake of drugs, the molecular mechanisms behind this phenomenon are largely unknown. We treated cancer cells (MOLM-13) and healthy peripheral blood mononuclear cells (PBMCs) with ultrasound at three acoustic intensities (74, 501, 2079 mW/cm2) ± microbubbles. We subsequently monitored the intracellular res

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Kerneis, Sandrine, Jean-Michel Escoffre, John J. Galvin, et al. "Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study." Pharmaceutics 15, no. 2 (2023): 442. http://dx.doi.org/10.3390/pharmaceutics15020442.

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Sonoporation using microbubble-assisted ultrasound increases the permeability of a biological barrier to therapeutic molecules. Application of this method to the round window membrane could improve the delivery of therapeutics to the inner ear. The aim of this study was to assess the safety of sonoporation of the round window membrane in a sheep model. To achieve this objective, we assessed auditory function and cochlear heating, and analysed the metabolomics profiles of perilymph collected after sonoporation, comparing them with those of the control ear in the same animal. Six normal-hearing

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Watabe, Tomoichi, Kazufumi Matsuyama, Tomoki Takahashi, and Hideto Matsuyama. "The effect of microbubbles on membrane fouling caused by different foulants." Desalination and Water Treatment 57, no. 21 (2015): 9558–68. http://dx.doi.org/10.1080/19443994.2015.1031186.

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Zhou, Yu, Xi-Yuan Zhou, Zhi-Gang Wang, Ye-Feng Zhu, and Pan Li. "Elevation of plasma membrane permeability upon laser irradiation of extracellular microbubbles." Lasers in Medical Science 25, no. 4 (2010): 587–94. http://dx.doi.org/10.1007/s10103-010-0773-1.

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Gwenaelle, Manvoudou Pissibanganga Ordelia, Jungwoo Jung, Yongjun Choi, and Sangho Lee. "Effect of microbubbles on microfiltration pretreatment for seawater reverse osmosis membrane." Desalination 403 (February 2017): 153–60. http://dx.doi.org/10.1016/j.desal.2016.06.012.

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Bjånes, Tormod, Spiros Kotopoulis, Elisa Thodesen Murvold, et al. "Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells." Pharmaceutics 12, no. 2 (2020): 141. http://dx.doi.org/10.3390/pharmaceutics12020141.

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Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles to increase the permeability of cell membranes. We assessed gemcitabine uptake combined with sonoporation in vitro in three PDAC cell lines (BxPC-3, MIA PaCa-2 and PANC-1). Cells were cultured in hypoxic bioreactors, while gemcitabine incubation ± sonoporation was conducted in cells with operational or inhibited nucleoside membrane transporters. Intracellular active metab

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Memari, Elahe, and Brandon Helfield. "The role of fluid flow patterns in microbubble-mediated endothelial cell membrane permeabilization." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A51. http://dx.doi.org/10.1121/10.0026764.

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Blood flow dynamics vary throughout the circulatory system, influencing the pathophysiology of vascular endothelium. We investigated endothelial cell response to ultrasound-stimulated microbubbles across diverse anatomical sites by mimicking assorted blood flow patterns. First, we examined the effect of culture condition on cell sensitivity to sonication by culturing HUVECs either statically or under pulsatile flow (8 or 16 dyn/cm2) for two days. Flow chambers were then co-perfused with microbubbles and propidium iodide under pulsatile flow (8 or 16 dyn/cm2) and sonicated (1MHz, 20 cycles, 1ms

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Ibsen, Stuart. "Membrane effects from ultrasound interactions with microbubbles—From drug delivery to mechanotransduction." Journal of the Acoustical Society of America 150, no. 4 (2021): A53. http://dx.doi.org/10.1121/10.0007600.

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Zlitni, Aimen, Melissa Yin, Nancy Janzen, et al. "Development of prostate specific membrane antigen targeted ultrasound microbubbles using bioorthogonal chemistry." PLOS ONE 12, no. 5 (2017): e0176958. http://dx.doi.org/10.1371/journal.pone.0176958.

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Anbarafshan, Rojin, Carly Pellow, Kevin Kiezun, Hon Leong, and David E. Goertz. "In vivo high-speed microscopy of microbubbles in the chorioallantoic membrane model." Theranostics 14, no. 5 (2024): 1794–814. http://dx.doi.org/10.7150/thno.91232.

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Deschamps, Laure, Julien Lemaire, Nabila Imatoukene, Michel Lopez, and Marc-André Theoleyre. "Evaluation of Gas-to-Liquid Transfer with Ceramic Membrane Sparger for H2 and CO2 Fermentation." Membranes 12, no. 12 (2022): 1220. http://dx.doi.org/10.3390/membranes12121220.

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Hydrogen and carbon dioxide fermentation to methane, called bio-methanation, is a promising way to provide renewable and easy-to-store energy. The main challenge of bio-methanation is the low gas-to-liquid transfer of hydrogen. Gas injection through a porous membrane can be used to obtain microbubbles and high gas-to-liquid transfer. However, the understanding of bubble formation using a membrane in the fermentation broth is still missing. This study focused on the impact of liquid pressure and flow rate in the membrane, gas flow rate, membrane hydrophobicity, surface, and pore size on the ove

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Rubin, David, Nicole Anderton, Charl Smalberger, Jethro Polliack, Malavika Nathan, and Michiel Postema. "On the Behaviour of Living Cells under the Influence of Ultrasound." Fluids 3, no. 4 (2018): 82. http://dx.doi.org/10.3390/fluids3040082.

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Medical ultrasound technology is available, affordable, and non-invasive. It is used to detect, quantify, and heat tissue structures. This review article gives a concise overview of the types of behaviour that biological cells experience under the influence of ultrasound only, i.e., without the presence of microbubbles. The phenomena are discussed from a physics and engineering perspective. They include proliferation, translation, apoptosis, lysis, transient membrane permeation, and oscillation. The ultimate goal of cellular acoustics is the detection, quantification, manipulation and eradicat

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Xie, Bingqi, Caijin Zhou, Junxin Chen, Xiaoting Huang, and Jisong Zhang. "Preparation of microbubbles with the generation of Dean vortices in a porous membrane." Chemical Engineering Science 247 (January 2022): 117105. http://dx.doi.org/10.1016/j.ces.2021.117105.

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Huang, Manhong, Zheng Liang, Long-Fei Ren, et al. "Robust mitigation of FO membrane fouling by coagulation-floatation process: Role of microbubbles." Desalination 531 (June 2022): 115693. http://dx.doi.org/10.1016/j.desal.2022.115693.

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Watabe, Tomoichi, Tomoki Takahashi, Kazufumi Matsuyama, and Hideto Matsuyama. "Effect of microbubbles on membrane fouling due to protein in water treatment processes." DESALINATION AND WATER TREATMENT 120 (2018): 9–15. http://dx.doi.org/10.5004/dwt.2018.22706.

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HASEGAWA, Hiroaki, and Satomi OTSU. "Improvement of Separation Ability of Membrane Using Microbubbles in Reverse Osmosis Desalination Technique." TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B 77, no. 783 (2011): 2049–57. http://dx.doi.org/10.1299/kikaib.77.2049.

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Zhao, Ying-Zheng, Yu-Kun Luo, Cui-Tao Lu, et al. "Phospholipids-based microbubbles sonoporation pore size and reseal of cell membrane culturedin vitro." Journal of Drug Targeting 16, no. 1 (2008): 18–25. http://dx.doi.org/10.1080/10611860701637792.

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Liu, Yefei, Yang Han, Xiaoli Li, Hong Jiang, and Rizhi Chen. "Controlling microbubbles in alcohol solutions by using a multi-channel ceramic membrane distributor." Journal of Chemical Technology & Biotechnology 93, no. 8 (2018): 2456–63. http://dx.doi.org/10.1002/jctb.5602.

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Conway, Grace E., Anurag N. Paranjape, Xucai Chen, and Flordeliza S. Villanueva. "Ultrasound-targeted microbubble cavitation increases paracellular gaps in an in vitro blood brain barrier model." Journal of the Acoustical Society of America 151, no. 4 (2022): A152. http://dx.doi.org/10.1121/10.0010943.

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Background: Ultrasound-targeted microbubble cavitation (UTMC) can transiently open the blood brain barrier (BBB). We sought to determine the timeline of paracellular gap formation after UTMC in an in vitro model of the BBB. Methods: We utilized a transwell model with murine brain endothelial cells (EC) and astrocytes on opposite sides of a support membrane. Ultrasound (1 MHz, 10 μ s duration, 10 ms pulse interval) at 250 kPa was applied to lipid microbubbles in contact with ECs for 20 s. Z-stacks of transwells acquired by confocal microscopy were converted to maximum intensity projections to q

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Marmottant, Philippe, Thierry Biben, and Sascha Hilgenfeldt. "Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles." Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 464, no. 2095 (2008): 1781–800. http://dx.doi.org/10.1098/rspa.2007.0362.

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Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the l

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Goweida, Mohamed Bahgat, Mazen Amgad Dowidar, Wael Abdel Rahman Elmenawy, and Ahmed Shalaby Bardan. "Deep Anterior Lamellar Keratoplasty with Central Descemet’s Membrane Baring in Eyes with Type 2 Bubble." Journal of Current Ophthalmology 36, no. 3 (2024): 267–71. https://doi.org/10.4103/joco.joco_94_24.

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Purpose: To review the outcomes of deep anterior lamellar keratoplasty (DALK) with formed type 2 bubble, managed with microbubbles-assisted manual dissection combined with central baring of Descemet’s membrane (DM). Methods: This is a retrospective interventional case series including eyes with formed type 2 bubble during DALK, and opacified pre-Descemet’s layer (PDL), done between January 2017 and February 2022. In eyes with type 2 bubbles, microbubbles-assisted manual dissection was done followed by baring of DM only in the central 4–5 mm. In eyes with mixed bubbles, the type 1 bubble is use

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Fazel, Maqsood, and S. Chesters. "RO membrane cleaning using microbubbles at 6,800 m3/d wastewater RO plant in UAE." Desalination and Water Treatment 55, no. 12 (2014): 3358–66. http://dx.doi.org/10.1080/19443994.2014.940216.

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Czarnota, Gregory J. "Ultrasound-stimulated microbubble enhancement of radiation response." Biological Chemistry 396, no. 6-7 (2015): 645–57. http://dx.doi.org/10.1515/hsz-2014-0297.

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Abstract Cancer therapies result in the killing of cancer cells but remain largely ineffective, with most patients dying of their disease. The methodology described here is a new image-guided cancer treatment under development that relies on physical methods to alter tumour biology. It enhances tumour responses to radiation significantly by synergistically destroying tumour blood vessels using microbubbles. It achieves tumour specificity by confining the ultrasonic fields that stimulate microbubbles to tumour location only. By perturbing tumour vasculature and activating specific genetic pathw

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