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Dissertations / Theses on the topic 'Memory reconsolidation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Honsberger, Michael. "Parsing memory structure with reconsolidation." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104703.

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Neural populations in the basolateral amygdala (BLA) have been shown to be an essential substrate for associative fear memories. However, it remains unclear whether distinct associative memories are mediated by independent or overlapping populations of BLA neurons. The focus of this dissertation is to describe efforts undertaken to use reconsolidation to advance this issue. I used the fact that initiation of reconsolidation is dependant on the reactivation of a particular memory. Therefore, if two memories are stored by the same overlapping population within the BLA, then interference thro

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2

Exton-McGuinness, Marc Thomas James. "Neural mechanisms of memory reconsolidation." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4858/.

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This thesis investigates the mechanisms of memory reconsolidation, with a particular focus on instrumental memories. Memories are dynamic in nature and can destabilise and re-stabilise in order to strengthen and update with new information. Destabilisation renders memories labile and vulnerable to amnestic intervention, requiring a reconsolidation phase in order to return to a stable form. Reconsolidation has been demonstrated in a great many memory settings, however the memories underpinning instrumental behaviours have not yet been shown to undergo reconsolidation. Starting from the hypothes

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3

Vargas, Iliana M. "RECONSOLIDATION OF MEMORY IN OLDER ADULTS." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/193018.

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4

Corbin, Stacey Michelle Pest, and Stacey Michelle Pest Corbin. "The Effects of Healthy Aging On Memory Reconsolidation." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625609.

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Reconsolidation theory states that stabilized memories can be reactivated and altered in some way; the memory must then be made stable once again by a process known as reconsolidation. A substantial number of studies have aimed to examine this process and the conditions under which it can occur in animal models and young adults. However, few studies have examined the impact of aging on memory reconsolidation. It has been established that aging affects episodic memories, as a result of several different changes in aging. Further, associative, source, and context memories have been found to be a

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5

Marinos, Julia. "Can Fearful Memories be Updated? Understanding the Boundary Conditions of Reconsolidation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42114.

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Reconsolidation is the process where consolidated memories return to a malleable state and can be modified. The purpose of this dissertation was to examine factors that influence the reconsolidation of conditioned fear memories using a behavioural method, known as the post-retrieval extinction paradigm, across two separate studies. Fear potentiated startle (FPS) and skin conductance response (SCR) were used as measures of fear for both studies. In Study 1, I investigated how the expectation for learning impacts the reconsolidation of conditioned fear memories. Testing took place over three

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6

Kochli, Daniel Edward. "NMDA and dopaminergic contributions to context fear memory reconsolidation." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami150065280374774.

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7

OTTS, AUNA. "MEMORY RECONSOLIDATION IN THE PRESENCE AND ABSENSE OF SLEEP." Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/190715.

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8

Wager, Erica Elizabeth. "Spatial Awareness and Memory Reconsolidation: The Role of Spatial Awareness in Memory Updating." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/244842.

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Hubach, Gomez, Hardt and Nadel (2007) provided the first demonstration of reconsolidation of episodic memory in humans. Memory for a set of20 objects was modified by the presentation of a new set of 20 objects if and only if participants were reminded of the first learning episode before learning the new set. Hupbach, Hardt, Gomez and Nadel (200S) then explored the importance of spatial context in the reminder condition. A bimodal split between participants in memory updating occurred when they were brought to a different context for Session 3. The present study investigates this bimodal split

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9

Bryant, Natalie B., and Natalie B. Bryant. "Sleep and Memory Updating." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626309.

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Prior research shows that a contextual reminder can return a previously consolidated memory to an unstable state similar to initial encoding. New knowledge presented before the trace is reconsolidated can emerge as updating of the first experience with knowledge from the second. Sleep has been implicated in the long-term strengthening and storage of newly acquired episodic memories; thus, the delay-dependent emergence of intrusions may be facilitated by a delay containing sleep. The experiments described here explore this possibility by tracking sleep while participants undergo an episodic rec

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10

von, Hertzen Laura Sisko Johanna. "Analysis of memory consolidation and reconsolidation in the mouse hippocampus." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446748/.

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Our brain processes enormous amounts of information subserving the formation and retrieval of memory. A fresh memory is an unstable trace that is stabilised by a process termed consolidation. This depends on de novo transcription. Reactivating a stabilised memory returns it to a labile state, and triggers a second consolidation process, termed reconsolidation, re-stabilising the memory again. This study used two transcriptional screens to determine the molecular relationship between consolidation and reconsolidation. Three immediate-early genes were identified to be regulated in the hippocampu

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11

Lonergan, Michelle. "Memory reconsolidation blockade for treating substance dependence: a feasibility study." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123311.

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Background: According to the pathological memory model of addiction, conditioned drug-related memories formed during repeated drug using episodes underlie craving and the long-term propensity for addicted individuals to relapse, posing a formidable barrier to sustained recovery. However, reconsolidation theory suggests that the act of retrieval transiently destabilizes previously consolidate memories, during which time they can be pharmacologically manipulated prior to re-stabilizing back to long-term storage. Previous literature has revealed that the noradrenergic beta-blocker propranolol can

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12

Chow, Jonathan J. "EXAMINING MEMORY CONSOLIDATION AND RECONSOLIDATION IN AN APPETITIVE PAVLOVIAN TASK." UKnowledge, 2015. http://uknowledge.uky.edu/psychology_etds/84.

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Memory plays an important role in defining how one behaves. The neurobiological mechanisms of memory have been studied extensively in animal models and the NMDA glutamate receptor has been identified to play an important role in the consolidation and reconsolidation of appetitive memories. Certain memories, depending on what was learned, can function differently and can be more difficult to disrupt based on a number of factors. Currently, no study has examined whether or not a reward-predictive stimulus attributed with incentive value is more difficult to disrupt than a stimulus that functions

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13

Michael, Rianne Janai. "Anxiety and Memory: The Influence of Oxytocin and Corticosterone on Memory Reconsolidation in Rats." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321898.

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14

Jones, Bethany Jayne. "Investigating Spatial Memory Reconsolidation in Rats: Memory Updating, Effects of Aging, and Hippocampal Network Activity." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/283605.

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Upon acquisition, memories undergo an initial stabilization, or consolidation, process after which they are generally resistant to interference. There is now an abundance of evidence that reactivation or retrieval of a consolidated memory opens up a window of time during which the memory can be strengthened, disrupted, or updated via a process of "reconsolidation". This dissertation is comprised of three experimental studies in rats aimed at investigating previously unexamined aspects of this dynamic memory process. The first study assessed whether spatial memories learned under positively-mot

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15

Bartolomeo, Lisa Ann. "Pupil Dilation as a Measure of Cognitive Effort During Memory Reconsolidation." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579241.

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The pupil is known to dilate in response to numerous cognitive processes, thereby making it a sensitive measure of cognitive effort. While evidence from previous pupilometry studies demonstrates that the pupil dilates during memory encoding and retrieval, the present study aims to determine how pupil dilation reflects the amount of cognitive effort exerted at encoding and retrieval for correctly-recognized and updated information. Ten consenting, volunteer subjects from the University of Arizona completed a classic reconsolidation paradigm that spanned the course of one week, in which subjects

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16

Milton, Amy Louise. "Neuropharmacological mechanisms underlying memory reconsolidation : implications for the treatment of neuropsychiatric disorders." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611882.

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17

Pierson, Jamie L. "The Role of Prediction Error in the Reconsolidation of Contextual Fear Memory." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564058234405263.

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18

Catallini, Mary Carroll. "Reconsolidation and the Role of Retrieval Context in Human Episodic Memory Recall." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146590.

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The reconsolidation effect shows that memory can be reactivated and returned to a labile state, where it can be modified and reconsolidated to include new information. This study investigates the role of recall context in memory reconsolidation. Participants were taught a set of 20 objects in one location (context A) and a second set 48 hours later in a new location (context B) after either receiving a reminder of Day 1 or receiving no reminder. Fortyeight hours later they were asked to recall one set of objects while in context B. As anticipated, a one-way effect was demonstrated in which som

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19

Simon, Katharine Claude Newman Smith, and Katharine Claude Newman Smith Simon. "Exploration of Factors Influencing Memory Reactivation and Updating." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/626326.

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Memory updating has been established; however, the mechanism supporting this alteration process is subject to disagreement. Reconsolidation theorists argue that memory updating occurs via an old memory becoming reactivated and returned to a state of susceptibility. In this state, newly presented details can become incorporated into the existing memory. As such, memory updating is an effect of old memory reactivation and new information encoding. In contrast, temporal context theory argues that the temporal context in which the old memory was initially formed is reinstated. Newly presented info

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20

Dongaonkar, Bhaktee. "Effects of Psychosocial Stress on Episodic Memory Updating." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/241936.

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The malleable nature of human memory has been the focus of considerable research in recent years. Memory is no longer viewed as permanent and non-modifiable. When a consolidated memory is reactivated it becomes labile and modifiable again. Recently, updating of reactivated memory has been demonstrated, manifesting as the addition of new but relevant information. New, similar, information that is acquired in a separate learning episode is embedded within the original memory. We were interested in exploring the effects of psychosocial stress on this episodic memory updating. Individuals were str

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21

Kumar, Shikhar. "Role of Semantics in the Reconsolidation of Episodic Memories." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/242452.

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Evidence suggests that when memories are reactivated they become labile and can be updated or even erased. Reactivation induces plasticity in memory representations, rendering them fragile, much as they were after initial acquisition. When a memory has been reactivated it must be re-stabilized, which requires reconsolidation. A recent set of studies established the phenomenon of memory reconsolidation for episodic memory (Hupbach et al., 2007, 2008, 2011). That reconsolidation effects apply to explicit memory, which requires conscious recollection, has far reaching implications. In the Hupbac

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22

Campbell, Jennifer Lynn. "EXAMINING THE INFLUENCE OF TIME AND REPETITION ON RECENT AND REMOTE AUTOBIOGRAPHICAL MEMORY RETRIEVAL USING fMRI." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195373.

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Repetition and the passage of time influence the consolidation of long-term episodic memories. The experiments presented here have explored the influence of repetition on recent and remote autobiographical memories both behaviorally with regard to qualitative and quantitative measures of content, and neuroanatomically, focusing on changes within the hippocampus and adjacent structures. The first experiment tested the prediction made by MTT that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. An fMRI paradigm was used to compare the effect of memory

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23

Barnes, Gary W. "Retrograde amnesia and reconsolidation of a context-no US association." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1311122134.

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24

Pontes, Arthur Henriques. "Temporal proteomic analysis of rat hippocampus provides evidence for memory reconsolidation in operant conditioning." reponame:Repositório Institucional da UnB, 2018. http://repositorio.unb.br/handle/10482/33824.

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Tese (doutorado)—Universidade de Brasília, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Biologia Molecular, 2018.<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).<br>Os animais são capazes de guardar informações adquiridas do mundo exterior em forma de memórias. A formação de memórias ocorre através de um rearranjo de circuitos neurais, que é provocado por alterações na transcrição, tradução e adição de grupos químicos em proteínas em forma de mudanças pós-traducionais (PTMs) em células de regiões específicas do sist

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25

Vousden, George Henry. "An assessment of reconsolidation blockade to disrupt memories relevant to psychiatric disorders." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267292.

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Consolidated memories can become reactivated in order to permit the integration of new information into the memory trace. Blockade of the resultant process, reconsolidation, with NMDA receptor antagonists or protein synthesis inhibition can lead to a decrease in subsequent memory expression. This may offer a potential tool for the treatment of psychiatric disorders characterised by maladaptive memories, including drug addiction and post-traumatic disorder. Given the importance of instrumental associations in supporting drug addiction experiments in Chapters 3 & 4 aimed to disrupt reconsolidati

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26

Ågren, Thomas. "Erasing Fear : Effect of Disrupting Fear Memory Reconsolidation on Central and Peripheral Nervous System Activity." Doctoral thesis, Uppsala universitet, Institutionen för psykologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180202.

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Fear memories, here defined as learned associations between a stimulus and a physiological fear reaction, are formed through fear conditioning. In animals, fear memories, present in the lateral amygdala, undergo reconsolidation after recall. Moreover, this reconsolidation process can be disrupted both pharmacologically and behaviourally, resulting in a reduced fear response to the stimulus. This thesis examines the attenuation of fear memories by disrupting reconsolidation in humans, using measures of both the central and peripheral nervous system activity. Serotonergic and dopaminergic genes

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27

Wood, Melissa Allison. "A psychological analysis of the effects of memory retrieval prior to extinction on the reacquisition of a conditioned fear association." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/237034.

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The successful reduction of fear is the aim of clinicians treating people with anxiety disorders such as post-traumatic stress disorder or phobias. Existing treatments for these conditions, however, require many treatment sessions and are prone to relapse. A new technique, first demonstrated in rats by Monfils, Cowansage, Klann, & LeDoux (2009) and later shown to be effective in humans (Schiller et al., 2010), provides a method of efficiently reducing fear in a manner which is resistant to various known triggers of relapse. This procedure involves a single presentation of the fear-inducing sti

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James, Ella L. "Exploring the use of Tetris as a post-trauma 'cognitive vaccine' : from memory consolidation to reconsolidation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39cf0ad2-f214-495e-a39f-fdaff4e882e8.

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Re-experiencing trauma in the form of intrusive, image-based memories (here referred to as flashbacks) is a hallmark symptom of Post-Traumatic Stress Disorder (PTSD). There are successful treatments available for full-blown PTSD; however, these can only be administered one month post trauma. There are limited interventions that can be administered to reduce flashbacks in the early aftermath of trauma. The overarching aim of this thesis was to use an experimental psychopathology approach, the trauma film paradigm, to investigate the reduction of flashbacks post-trauma using the cognitive task,

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29

Lagasse, Fabrice. "Modularity and Plasticity of olfactory learning and memory in Drosophila." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T108/document.

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La cognition se réfère aux mécanismes par lequel l’animal perçoit, apprend, mémorise et agit selon les informations auquel il est confronte dans son environnement. Les animaux on chacun leur propre monde sensoriel et il est primordial qu’ils s’y adaptent en développant des compétences spécialisées en fonction des informations sensorielles qui lui sont le plus utile. Il en est de même des informations qu’il est utile de stocker afin de pouvoir les utiliser ultérieurement. Les mécanismes sous-jacents à ces processus d’adaptation comportementale sont lies à la plasticité du système. Comment cette

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Einarsson, Einar. "The anterior cingulate cortex in contextual fear memory: from formation, consolidation, and reconsolidation, to mediating context generalization." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107666.

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To persist, new memories must undergo a consolidation process, during which they are sensitive to disruption. This process, referred to as cellular consolidation, is posited to be completed within the first hours following learning and involves stabilization of changes in synaptic connectivity. Memories can also consolidate at the level of brain systems. Systems-consolidation is a more prolonged process involving gradual reorganization of brain systems that support memory expression, where memories that initially depend on the hippocampus increasingly come to depend on specific cortical struct

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31

Meir, Drexler Shira [Verfasser], Oliver T. [Gutachter] Wolf, and Martin [Gutachter] Brüne. "Cortisol and stress modulation of fear memory reconsolidation / Shira Meir Drexler. Gutachter: Oliver T. Wolf ; Martin Brüne." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/110503593X/34.

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Barnstedt, Oliver. "Neural circuit mechanisms of memory coding in the Drosophila mushroom body." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:b3785c24-aa8c-49af-b176-9e06d151849e.

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Learning allows animals to adapt their behaviour to changes in the environment. In humans and other mammals, memories are stored in the hippocampus and cerebellum, whereas in insects, they are stored inside the mushroom bodies (MB). Here, MB-intrinsic Kenyon cells (KCs) form plastic synapses to MB output neurons (MBONs) that are modulated by the reinforcing action of dopaminergic neurons (DANs). Despite decades of research on the MB, the main neurotransmitter underlying the plastic KC → MBON synapse has remained a mystery. Here, I show that this synapse is cholinergic in the fruit fly Dro

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33

Ulmen, Adam Richard. "The NMDA receptor antagonist MK-801 renders pavlovian fear conditioning state-dependent." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1430140456.

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34

Michel, Maximilian. "Involvement of PKA and CREB in memory consolidation/reconsolidation after single-trial reward classical conditioning in Lymnaea stagnalis." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487896.

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This thesis presents the first set of evidence for a genuine PKA catalytic subunit in the central nervous system of the pond snail Lymnaea stagnalis, a well-established experimental system for the analysis of the molecular mechanisms of associative memory. The kinase is funCtionally conserved in that it can be visualized with anti-human PKA antibodies, it can phosphorylate a peptide designed for PKA and it can be inhibited by two commonly used specific inhibitors of PKA. Furthermore, the catalytic subunit was purified utilizing the holoenzyme's biochemical properties followed by fragmentation

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Murkar, Anthony. "Exploring Novel Treatment Approaches for Post-Traumatic Stress Disorder." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40040.

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Post-traumatic stress disorder is a disorder characterized by an inability to extinguish traumatic memories and heightened reactivity to emotional stimuli. Due to the heightened resistance of traumatic memories to extinction, treatment for PTSD has been challenging and is limited to behavioral therapies targeted at reducing responsivity to threatening stimuli. Currently there are no standard pharmacological interventions that are specific to PTSD; rather, drugs used appear to target symptoms of some of the co-morbid conditions, such as anxiety (e.g. benzodiazepines) or depression (antidepressa

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Jobim, Paulo Fernandes Costa. "Papel de mTOR na formação e reconsolidação da memória." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/35905.

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Novas informações assimiladas pelo sistema nervoso primeiramente ficam em um estado de labilidade para depois se estabilizarem através de um processo conhecido como consolidação, que envolve síntese de proteínas. Depois da reativação, uma memória previamente consolidada retorna ao seu estado de labilidade, e para que volte a ser estável, é necessário que haja novamente síntese de proteínas. Este segundo processo é chamado de reconsolidação. Recentemente os mecanismos moleculares e celulares envolvidos na regulação da síntese protéica relacionados à formação de memória de longa duração vêm send

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Lods, Marie. "Rôle de la neurogenèse hippocampique adulte dans la stabilisation à long terme de la mémoire spatiale." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0294/document.

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La neurogenèse hippocampique adulte fait référence à la création de neurones durant la vie adulte dans le gyrus denté de l’hippocampe. Une décennie de recherche a démontré l’importance de cette neurogenèse chez l’adulte dans les processus de mémoire. En particulier, la neurogenèse adulte est nécessaire à l’apprentissage spatial et l’apprentissage spatial lui-même augmente la survie et accélère le développement d’une population de nouveaux neurones immatures. Cependant, l’implication de ces nouveaux neurones « sélectionnés » par l’apprentissage dans le devenir de la mémoire reste incertaine. En

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Björkstrand, Johannes. "The Amygdala, Fear and Reconsolidation : Neural and Behavioral Effects of Retrieval-Extinction in Fear Conditioning and Spider Phobia." Doctoral thesis, Uppsala universitet, Institutionen för psykologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317866.

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The amygdala is crucially involved in the acquisition and retention of fear memories. Experimental research on fear conditioning has shown that memory retrieval shortly followed by pharmacological manipulations or extinction, thereby interfering with memory reconsolidation, decreases later fear expression. Fear memory reconsolidation depends on synaptic plasticity in the amygdala, which has been demonstrated in rodents using both pharmacological manipulations and retrieval-extinction procedures. The retrieval-extinction procedure decreases fear expression also in humans, but the underlying neu

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Ryan, Katherine M. "Methodological differences in Pavlovian fear learning, extinction and return of fear." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/410147.

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Examining methodological differences in fear conditioning and extinction studies is a growing area of research, inspired by the recent ‘replication crisis’ in psychological research. Determining whether methodological differences of fear conditioning and extinction paradigms contribute to inconsistent findings is important in terms of the translational value of this paradigm as an experimental analogue of exposure-based cognitive behavioural therapy. The aim of this thesis was to improve the experimental methodology of fear conditioning and extinction studies, by addressing three key questions

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Chen, Fujun. "Reciprocal relations among the nuclei of the amygdaloid complex and the locus coeruleus and their significance for learning and memory." Paris 6, 2007. http://www.theses.fr/2007PA066585.

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Les présentes études ont été réalisées pour explorer l’interaction fonctionnelle entre le noyau noradrénergique « Locus Coeruleus(LC) » et le noyau latéral basal de l’amygdale (BLA) in vivo, pendant l’apprentissage et la consolidation mnésique. Les neurones du BLA et du LC ont été enregistrés simultanément alors que le rat anesthésié recevait des chocs électriques sur une patte. Tous les neurones du LC ont montré une réponse excitatrice multiphasique suivie d’une inhibition prolongée. Les réponses des cellules du BLA furent majoritairement inhibitrices, avec une levée d’inhibition pendant la p

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Pereira, Natividade de Sá Couto. "Intervenções precoces durante o desenvolvimento como fatores de resiliência/ vulnerabilidade via modulação da reconsolidação de memórias aversivas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/158138.

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O estudo dos mecanismos neurobiológicos associados a memórias aversivas tem aplicações potenciais à prevenção e ao tratamento de patologias psiquiátricas associadas a memórias traumáticas. Em particular, o processo de reconsolidação, através do qual memórias evocadas são novamente estabilizadas, tem sido visto como um possível mecanismo na origem desses transtornos e, ao mesmo tempo, um alvo para estratégias terapêuticas. Experiências precoces influenciam o desenvolvimento e a maturação de circuitos encefálicos, e a sua interação com a carga genética do indivíduo, pode influenciar as estratégi

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Ribeiro, Daniela Aymone. "AGENTES POLIAMINÉRGICOS MODULAM A RECONSOLIDAÇÃO DA MEMÓRIA DE MEDO EM RATOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/11216.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The memory may be studied according with memory's phases, which is acquisition, consolidation and recall. Memories once consolidated, are no more susceptible to interventions, but when reactivated, some of these memories again become labile and vulnerable, and to persist need to have a new stabilization process called reconsolidation. Previous studies described that endogenous polyamines, spermine and spermidine, which bind and modulate the activity of NMDA receptors are involved in memory acquisition and consolidation. However the

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Kitamura, Haruka. "Boundary conditions of acquisition and post-retrieval extinction in fear conditioning: Individual differences and methodological factors." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207826/2/Haruka%20Kitamura%20Thesis.pdf.

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This thesis examined a range of potential reasons as to why people differ in how well the fear associated with a memory can be reduced. These reasons included the strength of the initial fear memory and individual differences such as the level of female hormones, strength of stress reaction, type of emotion regulation used, optimistic and neurotic personalities, and mood. The thesis revealed that stronger initial fear memories did not prevent the effective treatment of a fearful memory. It was also found that pessimism and hormonal contraception use prevent the effective reduction of the fear

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Rekik, Khaoula. "La mémoire hippocampo-dépendante : altérations dans un modèle de vieillissement accéléré et régulation par le système nociceptinergique chez la souris." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30327/document.

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La mémoire est définie comme une activité biologique et psychique qui permet d'emmagasiner, de conserver et restituer des informations. La formation de la mémoire à long terme a lieu en plusieurs étapes : acquisition, consolidation. Une fois consolidée, la mémoire peut être réactivée puis reconsolidée. C'est un processus dynamique qui au cours de la vie d'un individu peut subir des altérations physiologiques (vieillissement) ou pathologiques (maladies neurodégénératives, syndrome de stress post traumatique (PTSD)). Dans un premier temps nous avons caractérisé du point de vue comportemental les

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Girardi, Bruna Amanda. "A MELHORA DA RECONSOLIDAÇÃO DA MEMÓRIA INDUZIDA POR ESPERMIDINA ENVOLVE A PROTEÍNA CINASE DEPENDENTE DE CÁLCIO." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/9033.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The reactivation of a memory results in its destabilization, requiring a process of memory reconsolidation to maintain it. Spermidine is an endogenous aliphatic amine with polycationic structure that modulates N-methyl-D-aspartate (NMDA) receptor activity and improves memory. Recent evidence suggests that systemic administration of spermidine improves the reconsolidation of fear memory. Here we determined whether the calcium-dependent protein kinase (PKC) signaling pathway is involved in the improvement of fear memory reconsolidati

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Boos, Flávia Zacouteguy. "Reversão dos efeitos reforçadores da morfina através do prejuízo da reconsolidação da memória do condicionamento de preferência por local e da sensibilização locomotora." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/150201.

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A dependência de drogas é um transtorno multifatorial complexo que se desenvolve em uma minoria de indivíduos que fazem uso dessas substâncias. Memórias associativas entre a droga e o contexto funcionam como gatilho para disparar comportamentos não adaptativos de busca e consumo, além de recaídas após períodos de abstinência. Subjacentes a essas mudanças comportamentais, existem modificações nas subunidades de receptores glutamatérgicos do tipo AMPA em estruturas envolvidas com memória (Hipocampo) e recompensa (Núcleo Accumbens). Por isso, estratégias que enfraqueçam a associação do contexto c

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Sekeres, Melanie Jay. "CREB-mediated Enhancement of Hippocampus-dependent Memory Consolidation and Reconsolidation." Thesis, 2012. http://hdl.handle.net/1807/43394.

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Memory stabilization following encoding (synaptic consolidation) or memory reactivation (reconsolidation) requires gene expression and protein synthesis. Although consolidation and reconsolidation may be mediated by distinct molecular mechanisms, disrupting the function of the transcription factor CREB (cAMP responsive element binding protein) impairs both processes. We use a gain-of-function approach to show that CREB (and CREB-coactivator CRTC1) can facilitate both synaptic and systems consolidation and reconsolidation. We first examine whether acutely increasing CREB levels in the dorsal h

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Lai, Yu-Ting, and 賴郁婷. "Molecular Mechanisms for Retrieval and Reconsolidation of Cocaine-Associated Memory." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/04028923280729634933.

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碩士<br>國立成功大學<br>行為醫學研究所<br>96<br>Continuous drug use, context-induced drug craving, and relapse all manifest the critical roles of specific memory episodes associated with the drug use experiences. Memory for the drug-associated cues have been reported to resist extinction and contribute to the drug relapse; To date, little is known about the molecular mechanisms underlying the retrieval and reconsolidation of such drug memory. Amygdaloid complex has been known for its physiological function in mediating emotional experience storage and emotional cue-regulated memory retrieval. Otherwise the m

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Padovani, Laura. "Reconsolidation of appetitive memory and sleep: functional connectomics and plasticity." Doctoral thesis, 2020. http://hdl.handle.net/11562/1015855.

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Introduzione: La dipendenza da cibo è un disturbo comportamentale caratterizzato da modelli maladattativi di consumo alimentare, in cui alimenti ricchi in zuccheri, sale e/o grassi possono indurre una dipendenza tale da essere paragonata ai disturbi relativi all’abuso di sostanze. Alla base di questo processo vi è l’associazione tra questi cibi altamente palatabili e la sensazione piacevole e rinforzante indotta dal loro consumo, che può essere codificata in una nuova memoria maladattativa sottostante il disturbo di dipendenza. Infatti, le nuove informazioni che riceviamo quotidianamente dall’

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Helfrich, Alexandra Sofia Pontes Leite. "Reprogramming Fear Memory through the Inhibition of GSK-3 during Reconsolidation." Master's thesis, 2016. http://hdl.handle.net/10451/35771.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>A Perturbação de Stress Pós-Traumático (PSPT) é uma patologia psiquiátrica associada a um medo excessivo que atualmente afeta cerca de 7% da população ocidental. Apesar de se encontrarem disponíveis diversos tratamentos, nenhum deles conseguiu curar totalmente o medo desproporcionado associado à doença. As taxas de resposta à terapêutica são baixas e mais de 70% dos doentes não alcança remissão completa, destacando uma necessidade de investigação científica nesta área. Este pro

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